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EnTimeMent aims at a radical change in scientific research and enabling technologies for human movement qualitative analysis, entrainment and prediction, based on a novel neuro-cognitive approach of the multiple, mutually interactive time scales characterizing human behaviour. Our approach will afford the development of computational models for the automated detection, measurement, and prediction of movement qualities from behavioural signals, based on multi-layer parallel processes at non-linearly stratified temporal dimensions, and will radically transform technology for human movement analysis. EnTimeMent new innovative scientifically-grounded and time-adaptive technologies operate at multiple time scales in a multi-layered approach: motion capture and movement analysis systems will be endowed with a completely novel functionality, achieving a novel generation of time-aware multisensory motion perception and prediction systems. The proposed model and technologies will be iteratively tested and refined, by designing and performing controlled and ecological experiments, ranging from action prediction in a controlled laboratory setting, to prediction in dyadic and small group interaction. EnTimeMent scenarios include health (healing and support of everyday life of persons with chronic pain and disability), performing arts (e.g. dance), sports, and entertainment group activities, with and without living architectures. EnTimeMent will create and support community-building and exploitation with concrete initiatives, including a community of users and stakeholders, innovation hubs and SME incubators, as premises for the consolidation beyond the end of the project in a broader range of market areas.

COMFORT will close knowledge gaps for key ocean tipping elements under anthropogenic physical and chemical climate forcing through an interdisciplinary research approach. It will provide added value to decision and policy makers in terms of science based safe marine operating spaces, refined climate mitigation targets, and feasible long-term mitigation pathways. We will determine the consequences of passing tipping points in physical tipping elements for the marine carbon, oxygen, and nutrient cycles, as well as tipping points in biogeochemical tipping elements. The respective impact on marine ecosystems will be determined. Projections of the Earth system and impact studies have so far been carried out sequentially in a chain from scenarios to projections to off-line impact studies. This sequential workflow has hampered a quick response of the impact community back to revised scenarios and projections for tackling climate mitigation. COMFORT breaks new ground by bringing together experts from Earth system science, oceanography, fisheries science and ecology in a single integrated project who will work in parallel with a consistent set of analysis tools, scenarios, and interoperable models. The strength of COMFORT lies in the system-focused interdisciplinary approach as opposed to existing studies at the level of individual subsystems. The approach will be pursued with a firm link to stakeholders. COMFORT results will contribute to all four expected impacts for this call.

The objectives of the interdisciplinary project IQubits are to (i) develop and demonstrate experimentally high-temperature (high-T) Si and SiGe electron/hole-spin qubits and qubit integrated circuits (ICs) in commercial 22nm Fully-Depleted Silicon-on-Insulator (FDSOI) CMOS foundry technology as the enabling fundamental building blocks of quantum computing technologies, (ii) verify the scalability of these qubits to 10nm dimensions through fabrication experiments and (iii) prove through atomistic simulations that, at 2nm dimensions, they are suitable for 300K operation. The proposed 22nm FDSOI qubit ICs consist of coupled quantum-dot electron and hole spin qubits, placed in the atomic-scale channel of multi-gate n- and p-MOSFETs, and of 60-240GHz spin control/readout circuits integrated on the same die in state-of-the-art FDSOI CMOS foundry technology. To assess the impact of future CMOS scaling, more aggressively scaled Si-channel SOI and nitride-channel qubit structures will also be designed and fabricated in two experimental processes with 10nm gate half pitch. The latter will be developed in this project. The plan is for the III-nitrides (III-N) qubits to be ultimately grown on a SOI wafer, to be compatible with CMOS. Because of their larger bandgap, III-N hold a better prospect than Si and SiGe for qubits with larger coupling energy and mode energy splitting, and 300K operation. As a radical breakthrough, the fabricated qubits will feature coupling energies on the order of 0.25-1 meV corresponding to control frequencies in the 60-240GHz range, suitable for operation at 3–12 degrees Kelvin, two orders of magnitude higher than today's qubits. The tuned mm-wave circuits allow for 10-20ps spin control pulses which help to filter out wideband thermal noise and largely enhance the ratio between the gating and the decoherence times. Thermal noise filtering and fast control of the spin may lead to even higher temperature operation for a given energy-level splitting.

Modern aeroplanes are well equipped to cope with most common icing conditions. However, some conditions consisting of supercooled large droplets (SLD) have been the cause of tragic accidents over the last three decades. It was proven that there are certain types of aircraft which are not robust against these conditions as ice can form on unprotected areas of the lifting surfaces leading to loss of control. Consequently, authorities addressed these safety concerns by issuing new certification rules under Appendix O to ensure that future aircraft remain controllable in these conditions and can exit safely upon detection. Hence, the key to increasing overall aviation icing safety is the early and reliable detection of icing conditions to allow the necessary actions to be taken by the flight crew. SENS4ICE (SENSors and certifiable hybrid architectures for safer aviation in ICing Environment) directly addresses this need for reliable detection and discrimination of icing conditions. It proposes that an intelligent way to cope with the complex problem of ice detection is the hybridisation of different detection techniques: direct sensing of atmospheric conditions and/or ice accretion on the airframe, combined with indirect techniques in which the change of aircraft characteristics with ice accretion on the airframe is detected. SENS4ICE will address the development, test, validation, and maturation of the different detection principles, the hybridisation - in close cooperation with regulators to provide an acceptable means of compliance - and the final airborne demonstration of technology capabilities in relevant natural icing conditions. The contribution of SENS4ICE to increase aviation safety will be achieved by an international consortium of 20 partners (13 EU, 7 non-EU) with contributions from Brazil, Canada, Russia and the US. The 4-year project requests an overall EU-funding of 6.6M€ and benefits from a further 5.4M€ of activities being provided by the non-EU partners.

For almost 100 years, the evolution of humans has been summarized as a transition from small-brained bipeds with an ape-like body plan (referred to as australopiths), to large-brained striding bipeds with a human-like body plan (members of the genus Homo). This characterisation dominates popular perception of human evolution in the public sphere. However, three newly discovered fossil human (hominin) species (H. naledi, H. floresiensis and Australopithecus sediba) do not fit this simple transitional model in either morphology or time (the former two surviving contemporaneously with modern humans), and have re-ignited debate about the origin of the Homo lineage, including perceptions of the earliest putative Homo species, H. habilis. These new fossils raise fundamental questions about the ecological niches occupied by hominins and the inferred transitions between niches throughout human evolution. With NewHuman, I will pioneer a novel, interdisciplinary and holistic approach using cutting-edge analyses of internal structures of fossil hominin teeth and bones to reconstruct the adaptive niche of these enigmatic species and test whether there is an unrecognized adaptive branch on the human family tree. Specifically, NewHuman will employ ground-breaking imaging techniques and analytical tools to reveal never-before-examined tooth and bone structures in these hominins. In doing so, it will 1) characterize the behaviour of these enigmatic species and place them more firmly into their ecological environment; and 2) elucidate the adaptive strategy that was likely the transition from australopith-like hominin species to later Homo, but which also represents a highly successful lifeway that persisted for over 2 million years alongside the evolving human lineage. By achieving these ambitious aims, NewHuman will have a significant impact on hypotheses about human evolution, and could result in a paradigm shift that overturns current views on human evolutionary history.

Driven by a general movement in Asia to invest in Classical studies, the project Vietnamica aims for a historical and linguistic study of ancient, invaluable Vietnamese inscriptions, while also helping to determine a ground-breaking method for the use of epigraphic resources. In partnership with Han-Nôm Institute and Vietnam National University, the project is motivated by the recent divulgence of 40,000 paper stampings that reproduce the inscriptions engraved on the surfaces of 25,000 steles erected between the 16th to 20th century in Vietnam. These inscriptions, written in a complex Chinese embedded with the local vernacular, are conserved at the Han-Nôm Institute in Hanoi. Offering an unexpected counterpoint to existing official sources, these inscriptions prompt the study of rural inhabitants, monks and notables across an era of five centuries through their very own language. The project will produce a series of studies on popular Buddhism and its connection to the ancestor cult, donations and the role of women in the economy of gifting, and monetization and land property. Based on these themes, the project will record and analyze the logographic processes that the Vietnamese once used to transcribe the language they spoke. Such research - close to the field and to its people - was once a dream for scholars, and is now possible due to the corpus of stampings available. Characteristic of local histories, information is dispersed in fragments all throughout the corpus and it is first necessary to categorize the existing inscriptions. Vietnamica will rely on tools available through digital and computational humanities to construct a database of the stampings, connect it to data mapping, and on a more technical level, proceed with a segmentation of the text to allow for the automatic identification of the demotic characters. The results from the project will converge on a Platform (Vietnamica.eu) that is meant to remain accessible to researchers indefinitely.

Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. Our 20 partners from the EU, Canada and Australia form a global interdisciplinary team, which builds on previous and running national and EU-funded projects and many established industry cooperations. In BovReg we will generate functional genome data based on FAANG core assays from representative bovine tissues and newly established cell lines covering different ontological stages and phenotypes applying novel bioinformatic pipelines. We will establish detailed knowledge on traits related to robustness, health and biological efficiency in cattle. Data, knowledge and protocols will be deposited in European biological archives, aiming to set up and maintain a knowledge hub and establish gold standards. Long-term availability of data and targeted dissemination and communication activities are guaranteed by EMBL-EBI, FAANG and EAAP. Our biology-driven genomic prediction tools will integrate biological knowledge on regulatory genomic variation into genomic selection schemes for local and global cattle populations. This improved knowledge will be useful for re-focussing cattle production, fully taking into account societal awareness, environmental and animal-welfare aspects and bio-efficiency.

Although the Ocean is a fundamental part of the global system providing a wealth of resources, there are fundamental gaps in ocean observing and forecasting systems, limiting our capacity in Europe to sustainably manage the ocean and its resources. Ocean observing is “big science” and cannot be solved by individual nations; it is necessary to ensure high-level integration for coordinated observations of the ocean that can be sustained in the long term. EuroSea brings together key European actors of ocean observation and forecasting with key end users of ocean observations, responding to the Future of the Seas and Oceans Flagship Initiative. Our vision is a truly interdisciplinary ocean observing system that delivers the essential ocean information needed for the wellbeing, blue growth and sustainable management of the ocean. EuroSea will strengthen the European and Global Ocean Observing System (EOOS and GOOS) and support its partners. EuroSea will increase the technology readiness levels (TRL) of critical components of ocean observations systems and tools, and in particular the TRL of the integrated ocean observing system. EuroSea will improve: European and international coordination; design of the observing system adapted to European needs; in situ observing networks; data delivery; integration of remote and in-situ data; and forecasting capability. EuroSea will work towards integrating individual observing elements to an integrated observing system, and will connect end-users with the operators of the observing system and information providers. EuroSea will demonstrate the utility of the European Ocean Observing System through three demonstration activities focused on operational services, ocean health and climate, where a dialogue between actors in the ocean observing system will guide the development of the services, including market replication and innovation supporting the development of the blue economy.

The aim of the IDIH project is to promote and increase international cooperation to advance digital health in the EU and key strategic countries to support active and healthy ageing through innovation. IDIH will identify shared priorities and set up a Digital Health Transformation Forum as a long-lasting and expert-driven catalyst to foster collaboration between the EU and five strategic third countries, i.e. Canada, China, Japan, South Korea and the USA. Overall, the IDIH project sets 4 targeted objectives. First, to support the definition of common priorities to enhance strategic international cooperation in digital health in line with policy orientations through a thorough analysis of priorities in Europe and each of the strategic third countries and close involvement of the relevant funding agencies. Secondly, to provide specific contributions to the international dialogue in digital health with the creation of a Digital Health Transformation Forum acting as umbrella for high-level experts in four thematic groups (Preventive care, Integrated care, Independent and connected living and Inclusive living). Thirdly, to facilitate the exchanges between RTI stakeholders from the EU and strategic third countries in digital health through international workshops, promotion of cooperation opportunities (guidebook, webinars, helpdesk) and joining forces with other initiatives. Fourthly, to foster international collaboration for digital solutions for health care benefitting the society and industry through networking and co-creation sessions in RTI workshops. The consortium partners have complimentary expertise, including healthcare & digital health, IT, H2020 project management, technology transfer etc. The consortium has close links to funding authorities and actors in the Digital Health Industry in all countries/regions and have wide networks in the community. As such, the consortium possesses expertise and tools to successfully realise the objectives of the project.

Hepatobiliary malignancies represent a major cause of mortality globally and are uniquely aggressive in Latin America. The most common tumors are: hepatocellular carcinoma (HCC) affecting young individuals in Latin America and being the second most common cause of cancer-related death worldwide; cholangiocarcinoma (CCA) with minimal survival upon diagnosis and largely understudied in the region; gallbladder cancer (GBC) being a rare tumor worldwide but representing the second most common cause of cancer-related death in women in Chile. Key factors related to the excessive mortality of these tumors are the lack of reliable screening methods and the complexity of diagnosis, which requires advanced imaging technology and difficult-to-access tissue. These barriers are amplified by poor accessibility present in resource-limited regions, all of which leads to tumors being diagnosed at advanced stages in which curative therapy is not an option. To overcome these barriers, we propose to: A) validate immune-related markers in serum to predict HCC in South America and evaluate factors associated to early HCC development; B) define the utility of extracellular vesicles in serum as biomarkers for diagnosis of CCA and determine genetic and infectious factors that increase risk for this cancer; and C) identify biomarkers for GBC detection and evaluate novel immune factors that affect the geographical impact of this tumor. This project advances the field by focusing on a unique approach to screen and diagnose tumors based on serum detection of biomarkers before a tumor is visible on imaging, allowing for early tumor detection in a cost effective manner that will lead to implementation of curative therapies. In addition, this project addresses modifiable risk factors for hepatobiliary tumors that could be targeted for prevention. This project will result in novel tools that are easily accessible and will dramatically reduce the burden of cancer-related mortality in Latin America.