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The EcoScope project will develop an interoperable platform and a robust decision-making toolbox, available through a single public portal, to promote an efficient, ecosystem-based fisheries management. It will be guided by policy makers and scientific advisory bodies, and address ecosystem degradation and the anthropogenic impact that are causing fisheries to be unsustainably exploited across European Seas. The EcoScope Platform will organise and homogenise climatic, oceanographic, biogeochemical, biological and fisheries datasets for European Seas to a common standard type and format that will be available through interactive mapping layers. The EcoScope Toolbox, a scoring system based on assessments of all ecosystem components, ecosystem and economic models, will operate as a decision-support tool for examining fisheries management and marine policy scenarios and spatial planning simulations. Groups of end-users and stakeholders will be involved in the design, development and operation of both the platform and the toolbox. Novel assessment methods for data-poor fisheries, including non-commercial species, as well as for biodiversity and the conservation status of protected megafauna, will be used to assess the status of all ecosystem components across European Seas and test new technologies for evaluating the environmental, anthropogenic and climatic impact on ecosystems and fisheries. A series of sophisticated capacity building tools (online courses, webinars and games) will be available to stakeholders through the EcoScope Academy. The EcoScope project will provide an effective toolbox to decision makers and end-users that will be adaptive to their capacity, needs and data availability. The toolbox will incorporate methods for dealing with uncertainty; thus, it will promote efficient, holistic, sustainable, ecosystem-based fisheries management that will aid towards restoring fisheries sustainability and ensuring balance between food security and healthy seas.

Recent literature has underlined the interplay among climate mitigation, adaptation, and finance, as well as between climate action and other development agendas, including sustainable resource use, human development and equity, and environmental pressures. Such an interconnected policy environment requires an integrated ecosystem of disciplines, methods, and tools. Despite the significant evolution of integrated assessment models (IAMs) in the last decade, there remain several criticisms on their design, use, and adequacy to respond to unaddressed and emerging questions in the light of the Paris Agreement and net-zero ambition. These include openness, legitimacy, and ownership, as well as technical feasibility to represent demand-side and broader societal transformations, cross-sectoral interactions, physical impacts and adaptation, climate finance and labour dynamics, and other sustainability goals. DIAMOND will update, upgrade, and fully open six IAMs that are emblematic in scientific and policy processes, improving their sectoral and technological detail, spatiotemporal resolution, and geographic granularity. It will further enhance modelling capacity to assess the feasibility and desirability of Paris-compliant mitigation pathways, their interplay with adaptation, circular economy, and other SDGs, their distributional and equity effects, and their resilience to extremes, as well as robust risk management and investment strategies. This will be done via integration of tools and insights from psychology, finance research, behavioural and labour economics, operational research, and physical science. We will develop a transdisciplinary scientific approach to legitimise the implementation process and co-create research questions that stretch the frontiers of climate science, as well as establish vibrant communities of practice to transparently open model enhancements and to develop capacities, thereby lowering the entrance barriers to the established IAM community.

Nanomedicine is the application of nanotechnology to medicine and healthcare. The field takes advantage of the physical, chemical and biological properties of materials at the nanometer scale to be used for a better understanding of the biological mechanisms of diseases at the molecular level, leading to new targets for earlier and more precise diagnostics and therapeutics. Nanomedicine, rated among the six most promising Key Enabling Technologies, is one of the most important emerging areas of health research expected to contribute to one of the strategic challenges that Europe has to face in the future: Provide effective and affordable health care and assure the wellbeing of an increasingly aged population. EuroNanoMed III (ENM III) builds on the foundations of ENM I & II, which launched 7 successful joint calls for proposals since 2009, funded 51 transnational research projects involving 269 partners from 25 countries/regions, and allocated € 45,5 million to research projects from ENM funding agencies. ENM III consortium, reinforced with 12 new partners from Europe, Canada and Taiwan, is committed to fostering the competiveness of European nanomedicine actors taking into account recent changes in the landscape and new stakeholders and challenges, as identified in the SRIA in nanomedicine. The first joint call for proposals will be co-funded by ENM III partners and the EC. After the co-funded call, three additional joint transnational calls will be organized and strategic activities will be accomplished in collaboration with key initiatives in the field. ENM III actions focus on translatability of project results to clinical and industry needs.

M-ERA.NET 3 aims at coordinating the research efforts in the participating EU Member States, Regions, and Associated States in materials research and innovation, including materials for future batteries, to support the circular economy and Sustainable Development Goals. A large network of national and regional funding organisations from 25 EU Members States, 4 Associated States and 6 countries outside Europe will implement a series of annual joint calls to fund excellent innovative transnational RTD cooperation, including one call for proposals with EU co-funding and additional non-cofunded calls. Continuing the activities started under the predecessor project M-ERA.NET 2 (3/2016-2/2021), the M-ERA.NET 3 consortium will address emerging technologies and related applications areas, such as - for example- surfaces, coatings, composites, additive manufacturing or integrated materials modelling. Research on materials supporting the large scale research initiative on future battery technologies will be particularly highlighted as a main target of the cofunded call (Call 2021) with a view to supporting in particular SDG 7 (“Affordable and clean energy”) by enabling electro mobility through sustainable energy storage technology and SDG 9 (“Industrial innovation and infrastructure”) by enhancing scientific research and upgrading the technological capabilities of industrial sectors. Several relevant action plans and initiatives will serve as programmatic guides for M-ERA.NET 3 when defining the joint activities, such as the Circular Economy Action Plan, the 2030 Agenda for Sustainable Development and its 17 Sustainable Development Goals, the EC communication “A clean planet for all”, and the “European Green Deal”. The total mobilised public call budget is expected to reach 150 million € with additional private investment of 50 million €. Thus, the leverage effect of the EU contribution will reach a factor of 13, exceeding by far the minimum required factor of 5.

The ECC-SMART is oriented towards assessing the feasibility and identification of safety features of an intrinsically and passively safe small modular reactor cooled by supercritical water (SCW-SMR), taking into account specific knowledge gaps related to the future licensing process and implementation of this technology. The main objectives of the project are to define the design requirements for the future SCW-SMR technology, to develop the pre-licensing study and guidelines for the demonstration of the safety in the further development stages of the SCW-SMR concept including the methodologies and tools to be used and to identify the key obstacles for the future SMR licencing and propose a strategy for this process. To reach these objectives, specific technical knowledge gaps were defined and will be assessed to achieve the future smooth licensing and implementation of the SCW-SMR technology (especially the behaviour of materials in the SCW environment and irradiation, validation of the codes and design of the reactor core will be developed, evaluated by simulations and experimentally validated). The ECC-SMART project consortium consists of EU, Canadian and Chinese partners to use the trans-continental synergy and knowledge developed separately by each partner. The project consortium and project scope were created according to the joint research activities under the International Atomic Energy Agency, Generation-IV International Forum umbrella and as much data as possible will be taken from the already performed projects. This project brings together the best scientific teams working in the field of SCWR using the best facilities and methods worldwide, to fulfil the common vision of building an SCW-SMR in the near future.

ERA-HDHL is a proposal of ERA-NET Cofund in the field of nutrition and health to support the Joint Programme Initiative Healthy Diet for a Healthy Life (JPI HDHL). Nowadays, there is a high burden of non-communicable diseases due to unhealthy diet and lifestyle patterns. The 24 members of the JPI HDHL are working together to develop means to (1) motivate people to adopt healthier lifestyles including dietary choices and physical activity, (2) develop and produce healthy, high-quality, safe and sustainable foods and (3) prevent diet-related diseases. Between 2012 and 2015, JPI HDHL had implemented 7 JFAs with 40 M€ funds from national funding. The JPI HDHL is now set for further enhancement in tight coordination with the EC through the ERA-NET Cofund instrument. ERA-HDHL will provide a robust platform for implementing joint funding actions (JFAs) that address the needs identified in the JPI HDHL strategic research agenda and strengthen the research funding activities of JPI HDHL. An EC cofunded call on the identification and validation of biomarkers in nutrition and health will be implemented. For this foreseen action, the member countries of the JPI HDHL have doubled their financial commitment comparing to previous JFA implemented on a similar topic. Moreover, ERA-HDHL will launch at least 3 additional JFAs in line to fulfil the JPI HDHL objectives.

euCanSHare will develop the first centralised, secure and sustainable platform for enhanced cross-border data sharing and multi-cohort personalised medicine research in cardiology. At its heart, the platform will contain the most comprehensive cardiovascular data catalogue ever assembled, which will facilitate data discoverability and exploitation in full alignment with the FAIR principles. The project will implement the interoperability of currently fragmented yet mature IT solutions developed by the consortium members for generating a comprehensive multi-functionality platform. It will also integrate major cardiovascular data sources from Europe and Canada, including the renowned MORGAM, BiomarCaRE and CAHHM initiatives. euCanSHare’s legal framework will be built through detailed ethical and legal interoperability analysis, while investigating innovative solutions for promoting responsible Open Science based on the emerging blockchain technology. Initially populated with 35 European and Canadian cohorts (corresponding to about one million records), the platform will provide extensive functionalities, including for data deposition, data harmonisation and quality control, which will support the integration of new cohorts beyond the duration of the project, thus ensuring its scalability. Moreover, sustainability will be targeted by leveraging through our multi-disciplinary partners the most established data infrastructures, namely ELIXIR, EGA, BBMRI and euro-BioImaging in Europe, as well as Maelstrom from Canada. The unique features of the platform will be demonstrated and adjusted through several use cases, including for biomarker validation, knowledge discovery, cardiovascular risk assessment, public health research and industry-driven studies. Furthermore, intensive outreach campaigns and hands-on workshops will be organised to attract a range of stakeholders, data providers and end-users from the academic, public health and industrial sectors.

The proposed Coordination and Support Action (CSA) has the overall objective to establish an international network of experts and stakeholders in the field of microbiome food system research, elaborating microbiomes from various environments such as terrestrial, plant, aquatic, food and human/animal and assess their applicability and impact on the food system. MICROBIOMESUPPORT will follow the approach of food system and integrate actors and experts from all stages in this circular economy of food. The food system approach is part of the FOOD 2030 concept to promote a systems approach to research and innovation (R&I). MICROBIOMESUPPORT will be one of the key drivers to implement FOOD 2030 strategies, will facilitate multi-actor engagement to align, structure and boost R&I in microbiome and will support the European Commission by coordinating the activities, meetings, workshops and results from the International Bioeconomy Forum (IBF) working group ‘Food Systems Microbiome’. The main concept behind MICROBIOMESUPPORT IS to boost the bioeconomy and the FOOD 2030 strategy, by focusing on the new avenues generated by microbiome R&I efforts. MICROBIOMESUPPORT WILL have a main impact on the coordination of commonly defined R&I agendas which will be incorporated into regional, national, European but also global funding programmes related to microbiomes in food systems. MICROBIOMESUPPORT will create a collaborative international network and integrate know-how in plant, terrestrial, animal, human and aquatic microbiome R&I as well as expertise in bioeconomy applications. MICROBIOMESUPPORT has integrated international partners form Brazil, Canada, South Africa, China, Argentina, Australia, New Zealand, India and USA in order to improve the international cooperation and coordination of common bioeconomy research programmes and set a basis for common microbiome R&I agendas.

ERA-MIN3 comprises a progressive, pan-European public-public partnership of 25 public research funding organisations from 19 European countries/regions and 3 third countries, which aims to continue strengthening the mineral raw materials (RM) community through the coordination of research and innovation (R&I) programmes on non-energy, non-agricultural raw materials (metallic, construction, and industrial minerals). ERA-MIN3 will thus contribute to the objectives of the EIP on Raw Material’s Strategic Implementation Plan and the EU Circular Economy Action Plan, in support of the EU Raw Materials Initiative, the UN sustainable development goals and the European Green Deal. Built on the successes of the previous ERA-MIN and ERA-MIN 2, and to ensure the EU’s resource security and sustainable supply of strategic RM to the European society, ERA-MIN3 will achieve its goals of improving synergy, coordination and coherence between regional, national and EU funding in the RM sector by reducing fragmentation of RM funding across Europe and globally, as well as, improving the use of human and financial resources, the competitiveness and the environmental, social, health and safety issues of RM operations through supporting of transnational, excellent and translational R&I activities. This will be achieved through a EU co-funded joint transnational call for R&I proposals and, at least, one additional call with participation of invited partners, on demand-driven R&I on primary and secondary resources, covering the entire value chain, from exploration, extraction and processing technologies to recycling and substitution of CRM, as well as, environmental and societal impact, new business models and/or public perception. ERA-MIN3 will liaison with RM related initiatives to ensure alignment of research topics (e.g. batteries), promote synergies and complementarities thus avoiding duplication of efforts and contributing for the circular economy and the sustainable development.

We are proposing a new and innovative precision approach to the identification of severe infections and sepsis in children. This data-driven approach to diagnosis will overcome many of the limitations of current expert opinion-based triage guidelines. Smart technology has the potential to overcome the barrier of limited clinical expertise in the identification of the child at risk. This mobile health platform, with sensors and data-driven applications, will provide real-time individualised risk prediction to facilitate timely and effective targeted treatment at first contact, regardless of location. This low-cost technology will provide rapid triage in remote areas globally where specialists are not regularly available. We will trigger rapid, highly effective and low-cost interventions such as antibiotics, fluid, oxygen therapy and other special investigations to children determined to be most at risk of sepsis, based on data-driven prediction. Thus, these innovations will improve timely access to life-saving treatments for children in the poorest countries where deaths from infection and sepsis are common. Children in poor families or in populations marginalized by health and social inequities are especially vulnerable to infections. In these children, infection is a major contributor to disability and years of life lost and has a great economic and social cost. Sepsis is the leading cause of death and disability in children, every hour of delay in treatment is associated with greater organ damage and ultimately death. The challenges, especially in poor countries, are the delays in diagnosis and the inability to identify children in urgent need of treatment. To circumvent these challenges, we propose the implementation and evaluation of a trigger tool that will reduce the time to diagnosis and prompt the timely initiation of life-saving treatment. The key innovations are 1) a data-driven approach to rapid diagnosis of sepsis severity and 2) a low-cost digital tagging system to track the time to treatment. The tool will require minimal cost, clinical expertise and training or time to use. The tool will identify high risk children and reduce time to treatment. Our mobile platform (mobile device and dashboard) will create a low-cost, highly scalable solution for children with sepsis.