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A long tradition of separate Nearctic and Palaearctic taxonomic studies of the diverse aleocharine rove beetles (Coleoptera: Staphylinidae) has obscured the recognition of Holarctic species and detection of adventive species in both regions. Recently, integrated study of the two regions through detailed morphological comparisons and development of an authoritatively identified DNA barcode reference library has revealed the degree to which these two aleocharine faunas are interconnected, both naturally and through human activity. Here this approach is adopted to recognize new species, reveal Holarctic species, and recognize adventive species in both North America and Europe. The following new species are described: Isoglossa triangularis Klimaszewski, Brunke & Pentinsaari, sp. nov. from British Columbia; Gnypeta impressicollis Klimaszewski, Brunke & Pentinsaari, sp. nov., from Ontario, Maryland and North Carolina; Aloconota pseudogregaria Klimaszewski, Brunke & Pentinsaari, sp. nov., from Ontario and Virginia; and Philhygra pseudolaevicollis Klimaszewski, Brunke & Pentinsaari, sp. nov. from eastern Canada. Dasygnypeta velata and Philhygra angusticauda are revealed to be Holarctic species, resulting in the following synonymies: Dasygnypeta velata (Erichson, 1839) = Gnypeta minuta Klimaszewski & Webster, 2008, syn. nov. and Philhygra angusticauda (Bernhauer, 1909) = Atheta (Philhygra) pinegensis Muona, 1983, syn. nov. The Nearctic species Hylota ochracea (and genus Hylota), Thecturota tenuissima, and Trichiusa robustula are newly reported from the Palaearctic region as adventive, resulting in the following synonymies: Hylota ochracea Casey, 1906 = Stichoglossa (Dexiogyia) forticornis Strand, 1939, syn. nov.; Thecturota tenuissima Casey, 1893 = Atheta marchii Dodero, 1922, syn. nov.; and Trichiusa robustula Casey, 1893 = T. immigrata Lohse, 1984, syn. nov. The Palaearctic species Amarochara forticornis, Anomognathus cuspidatus, Oligota pumilio, and Parocyusa rubicunda are newly confirmed from the Nearctic region as adventive, resulting in the following synonymies: Parocyusa rubicunda (Erichson, 1837) = Chilopora americana Casey, 1906, syn. nov. and Anomognathus cuspidatus (Erichson, 1839) = Thectura americana Casey, 1893, syn. nov. The genus Dasygnypeta, sensu nov. is newly reported from North America, Paradilacra is newly reported from eastern North America, and Haploglossa is newly reported from Canada, resulting in the following synonymy: Paradilacra densissima (Bernhauer, 1909) = Gnypeta saccharina Klimaszewski & Webster, 2008, syn. nov. Native Cyphea wallisi is newly reported from across Canada and C. curtula is removed from the Nearctic fauna. The status of both Gyrophaena affinis and Homalota plana is uncertain but these species are no longer considered to be adventive in North America. Three new combinations are proposed: Dasygnypeta baranowskii (Klimaszewski, 2020) and D. nigrella (LeConte, 1863) (both from Gnypeta) and Mocyta scopula (Casey, 1893) (from Acrotona). Dolosota Casey, 1910, syn. nov. (type species Eurypronota scopula Casey), currently a subgenus of Acrotona, is therefore synonymized with Mocyta Mulsant & Rey, 1874. Additionally, four new Canadian records and 18 new provincial and state records are reported.

Epigaeic beetle assemblages were surveyed using continuous pitfall trapping during the summers of 1992 and 1993 in six widely geographically distributed locations in Alberta’s aspen-mixedwood forests prior to initial forest harvest. Species composition and turnover (β-diversity) were evaluated on several spatial scales ranging from Natural Regions (distance between samples 120–420 km) to pitfall traps (40–60 m). A total of 19,885 ground beetles (Carabidae) representing 40 species and 12,669 rove beetles (non-AleocharinaeStaphylinidae) representing 78 species was collected. Beetle catch, species richness, and diversity differed significantly among the six locations, as did the identity of dominant species. Beetle species composition differed significantly between the Boreal Forest and Foothills Natural Regions for both taxa. Staphylinidae β-diversity differed significantly between Natural Regions, whereas Carabidae β-diversity differed among locations. Climate variables such as number of frost-free days, dry periods, and mean summer temperatures were identified as significant factors influencing beetle assemblages at coarse spatial scales, whereas over- and understory vegetation cover, litter depth, shade, slope, and stand age influenced beetle assemblages at finer spatial scales. Significant interannual variation in assemblage structure was noted for both taxa. Because composition of epigaeic beetle assemblages differed across spatial scales, forest management strategies based only on generalized understanding of a single location will be ineffective as conservation measures. In addition, site history and geographic variation significantly affect species distributions of these two beetle families across the landscape. Thus, we underscore Terry Erwin’s suggestion that biodiversity assessments focused on species assemblages at different spatial scales provide a sound approach for understanding biodiversity change and enhancing conservation of arthropod biodiversity.

Abstract This article analyzes the audio diaries of a Tibetan physician, originally from Amdo (Qinghai Province, China), now living in New York City. Dr. Kunchog Tseten describes his experiences during the first wave of the COVID-19 pandemic, in spring and summer 2020, when Queens, New York—the location where he lives and works—was the “epicenter of the epicenter” of the novel coronavirus outbreak in the United States. The collaborative research project of which this diary is a part combines innovative methodological approaches to qualitative, ethnographic study during this era of social distancing with an attunement to the relationship between language, culture, and health care. Dr. Kunchog’s diary and our analysis of its contents illustrate the ways that Tibetan medicine and Tibetan cultural practices, including those emergent from Buddhism, have helped members of the Himalayan and Tibetan communities in New York City navigate this unprecedented moment with care and compassion.

Abstract Biofilms that form on implanted medical devices cause recalcitrant infections. The early events enabling contaminating bacteria to evade immune clearance, before a mature biofilm is established, are poorly understood. Live imaging in vitro demonstrated that Staphylococcus aureus sparsely inoculated on an abiotic surface can go undiscovered by human neutrophils , grow, and form aggregates. Small (~50 μm 2) aggregates of attached bacteria resisted killing by human neutrophils, resulting in neutrophil lysis and bacterial persistence. In vivo, neutrophil recruitment to a peritoneal implant was spatially heterogenous, with some bacterial aggregates remaining undiscovered by neutrophils after 24 h. Intravital imaging in mouse skin revealed that attached S. aureus aggregates grew and remained undiscovered by neutrophils for up to 3 h. These results suggest a model in which delayed recruitment of neutrophils to an abiotic implant presents a critical window in which bacteria establish a nascent biofilm and acquire tolerance to neutrophil killing.

With the recent technological advances, biological datasets, often represented by networks (i.e., graphs) of interacting entities, proliferate with unprecedented complexity and heterogeneity. Although modern network science opens new frontiers of analyzing connectivity patterns in such datasets, we still lack data-driven methods for extracting an integral connectional fingerprint of a multi-view graph population, let alone disentangling the typical from the atypical variations across the population samples. We present the multi-view graph normalizer network (MGN-Net2), a graph neural network based method to normalize and integrate a set of multi-view biological networks into a single connectional template that is centered, representative, and topologically sound. We demonstrate the use of MGN-Net by discovering the connectional fingerprints of healthy and neurologically disordered brain network populations including Alzheimer’s disease and Autism spectrum disorder patients. Additionally, by comparing the learned templates of healthy and disordered populations, we show that MGN-Net significantly outperforms conventional network integration methods across extensive experiments in terms of producing the most centered templates, recapitulating unique traits of populations, and preserving the complex topology of biological networks. Our evaluations showed that MGN-Net is powerfully generic and easily adaptable in design to different graph-based problems such as identification of relevant connections, normalization and integration.

Various methods have been developed to synthesize CSH; however, these methods have only allowed for the successful production of pure-phase CSH with Ca:Si of 1.5 or less. Attempts to form higher Ca:Si ratios by these methods gives CSH (Ca:Si 1.5 or less) in the presence of Ca(OH)2. This paper focuses on a reliable method to produce single-phase CSH with Ca:Si molar ratios between 1 and 2. Reactant concentrations, temperature, pH, and mixing conditions are carefully controlled to ensure homogeneous precipitation of CSH. Guidelines on collection, drying, storage, and handling are also described.

[EN] An optical true time delay line (OTTDL) is a fundamental building block for signal processing applications in microwave photonics and optical communications. Here, we experimentally demonstrate an index-variable OTTDL based on an array of 40 subwavelength grating (SWG) waveguides in silicon-on-insulator. Each SWG waveguide in the array is 34 mm long and arranged in a serpentine manner; the average incremental delay between waveguides is about 4.7 ps, and the total delay between the first and last waveguides is approximately 181.9 ps. The waveguide array occupies a chip area of similar to 6.5mm x 8.7mm = 56.55mm(2). The proposedOTTDLs bring potential advantages in terms of compactness as well as operation versatility to a variety of microwave signal processing applications. Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; European Research Council (Consolidator Grant Project #724663).

The sharing of existing linguistic resources through online platforms has become an increasingly important aspect in revitalization projects for Indigenous languages. This contribution addresses the urgency of such work through the lens of a partnership in support of one language, Haíɫzaqvḷa (Heiltsuk), a critically endangered Wakashan language spoken in and around the traditional Heiltsuk territory of Bella Bella, British Columbia. Alongside immediate community needs for language preservation and reclamation—informed and guided by Heiltsuk values and goals—lie important ethical and practical questions about how best to activate historic recordings of Elders and knowledge holders who have now passed. Our partnership was explicitly structured around the objective of helping to mobilize the large body of existing language documentation and revitalization materials created in and by the community to support broader community access through digital technologies. Working within the fast-changing digital environment requires agility in order to respond to time-sensitive goals and the strategic needs of the community. Ensuring that such work is grounded in respectful collaboration requires ongoing care, consultation and consideration. The digital landscape is still a new and exciting space, and the opportunities to use online tools and technologies in service of language revitalization are ever increasing. We believe that the strategies, approaches and modest successes of the Heiltsuk Language and Culture Mobilization Partnership may be informative for other community-based language reclamation projects. We hope that outlining our experiences and being transparent about the challenges such partnerships face may help others engaged in this urgent and timely work.

Pain is a under-recognized association of leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies. Of 147 patients with these autoantibodies, pain was experienced by 17 of 33 (52%) with CASPR2- versus 20 of 108 (19%) with LGI1 antibodies (p = 0.0005), and identified as neuropathic in 89% versus 58% of these, respectively. Typically, in both cohorts, normal nerve conduction studies and reduced intraepidermal nerve fiber densities were observed in the sampled patient subsets. In LGI1 antibody patients, pain responded to immunotherapy (p = 0.008), often rapidly, with greater residual patient-rated impairment observed in CASPR2 antibody patients (p = 0.019). Serum CASPR2 antibodies, but not LGI1 antibodies, bound in vitro to unmyelinated human sensory neurons and rodent dorsal root ganglia, suggesting pathophysiological differences that may underlie our clinical observations. ANN NEUROL 2021;90:683-690.

Scientists have warned decision-makers about the severe consequences of the global environmental crisis since the 1970s. Yet ecological degradation continues and little has been done to address climate change. We investigated early-career conservation researchers' (ECR) perspectives on, and prioritization of, actions furthering sustainability. We conducted a survey (n = 67) and an interactive workshop (n = 35) for ECR attendees of the 5th European Congress of Conservation Biology (2018). Building on these data and discussions, we identified ongoing and forthcoming advances in conservation science. These include increased transdisciplinarity, science communication, advocacy in conservation, and adoption of a transformation-oriented social–ecological systems approach to research. The respondents and participants had diverse perspectives on how to achieve sustainability. Reformist actions were emphasized as paving the way for more radical changes in the economic system and societal values linked to the environment and inequality. Our findings suggest that achieving sustainability requires a strategy that (1) incorporates the multiplicity of people's views, (2) places a greater value on nature, and (3) encourages systemic transformation across political, social, educational, and economic realms on multiple levels. We introduce a framework for ECRs to inspire their research and practice within conservation science to achieve real change in protecting biological diversity.