Background— We have shown previously that triglyceride (TG) enrichment of HDL, as occurs in hypertriglyceridemic states, contributes to HDL lowering in humans by enhancing the clearance of HDL apolipoprotein (apo) A-I from the circulation. In the New Zealand White ra...

Background— Management of severe ischemic mitral regurgitation remains difficult with disappointing early and intermediate-term surgical results of valve repair. Methods and Results— Forty-four patients with severe (4+) Carpentier type IIIb ischemic mitral regurg...

We thank Dr Grocott for his comments on our recent review of sodium-glucose cotransporter-2 (SGLT2) inhibitors in Circulation .1 We fully agree that, although rare, there is a potential increased risk for the development of serious adverse effects with SGLT2 inhibitors ...

There is widespread recognition of the increasing challenge of conducting adequately powered clinical trials in cardiovascular medicine.1 Given the broadening gap between guideline-based recommendations and the level of evidence supported by trials, this matter is a cen...

BACKGROUND The degree of cardiac hypertrophy is not only load dependent: Among other factors, the renin-angiotensin system may play a role in the regulation of cardiac myocyte growth. METHODS AND RESULTS To evaluate the role of the renin-angiotensin system in volume ...

Background: Poor health-related quality of life (HRQL) is common in heart failure (HF), but there are few data on HRQL in HF and the association between HRQL and mortality outside Western countries. Methods: We used the Kansas City Cardiomyopathy Questionnaire–12 (KCCQ-...

Background— Atrial arrhythmias increase disease burden in the general adult population. Adults with congenital heart lesions constitute a rapidly growing group of patients with cardiovascular disease. We hypothesized that atrial arrhythmias increase with age and impa...

The patient is a 65-year-old white male with history of type 2 diabetes mellitus, hypertension, chronic smoking, and prior stroke with residual left hemiparesis and aphasia. His medication included losartan, furosemide, simvastatin, and metformin. He was admitted to the...

Background— The implantable cardioverter defibrillator (ICD) is superior to amiodarone for secondary prophylaxis of sudden cardiac death. However, the magnitude of this benefit over long-term follow-up is not known. Thus, our objective was to evaluate the long-term c...

Background —Rapid atrial pacing (RAP) and congestive heart failure (CHF) produce different experimental substrates for atrial fibrillation (AF). We tested the hypothesis that AF maintained by different substrates responds differently to antiarrhythmic-drug therapy. M...