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4,184 research outcomes, page 1 of 419
  • publication . Other literature type . Article . 2014
    Open Access English
    Authors:
    Nicole S. Hou; Aljona Gutschmidt; Daniel Y. Choi; Keouna Pather; Xun Shi; Jennifer L. Watts; Thorsten Hoppe; Stefan Taubert;
    Persistent Identifiers
    Publisher: National Academy of Sciences

    The Mediator is a conserved transcriptional coregulator complex required for eukaryotic gene expression. In Caenorhabditis elegans, the Mediator subunit mdt-15 is essential for the expression of genes involved in fatty acid metabolism and ingestion-associated stress res...

  • publication . Article . Other literature type . 2008
    Open Access
    Authors:
    Alder, Jonathan K.; Chen, Julian J.-L.; Lancaster, Lisa; Danoff, Sonye; Su, Shu-chih; Cogan, Joy D.; Vulto, Irma; Xie, Mingyi; Qi, Xiaodong; Tuder, Rubin M.; ...
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences

    Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased inciden...

  • publication . Other literature type . Article . 2009
    Open Access
    Authors:
    Sazzad M. Nasir; David J. Ostry;
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences

    Is plasticity in sensory and motor systems linked? Here, in the context of speech motor learning and perception, we test the idea sensory function is modified by motor learning and, in particular, that speech motor learning affects a speaker's auditory map. We assessed ...

  • publication . Article . 2018
    Open Access
    Authors:
    Campiglio, Marta; Costé de Bagneaux, Pierre; Ortner, Nadine J.; Tuluc, Petronel; Van Petegem, Filip; Flucher, Bernhard E.;
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences
    Project: FWF | Role of Ca2+ channels in ... (P 27031), FWF | Molecular mechanisms of t... (T 855)

    The adaptor proteins STAC1, STAC2, and STAC3 represent a newly identified family of regulators of voltage-gated calcium channel (CaV) trafficking and function. The skeletal muscle isoform STAC3 is essential for excitation–contraction coupling and its mutation causes sev...

  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Stephany El-Hayek; Isabelle Demeestere; Hugh J. Clarke;
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences

    Fertility depends on the precise coordination of multiple events within the ovarian follicle to ensure ovulation of a fertilizable egg. FSH promotes late follicular development, including expression of luteinizing hormone (LH) receptor by the granulosa cells. Expression...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Williams, Danielle M.; Ovchinnikova, Olga G.; Koizumi, Akihiko; Mainprize, Iain L.; Kimber, Matthew S.; Lowary, Todd L.; Whitfield, Chris;
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences
    Project: NSERC

    Lipopolysaccharides (LPS) are essential outer membrane glycolipids in most gram-negative bacteria. Biosynthesis of the O-antigenic polysaccharide (OPS) component of LPS follows one of three widely distributed strategies, and similar processes are used to assemble other ...

  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Portales-Casamar, Elodie; Swanson, Douglas J.; Liu, Li; de Leeuw, Charles N.; Banks, Kathleen G.; Ho Sui, Shannan J.; Fulton, Debra L.; Ali, Johar; Amirabbasi, Mahsa; Arenillas, David J.; ...
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences

    The Pleiades Promoter Project integrates genomewide bioinformatics with large-scale knockin mouse production and histological examination of expression patterns to develop MiniPromoters and related tools designed to study and treat the brain by directed gene expression...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Del’Guidice, Thomas; Latapy, Camille; Rampino, Antonio; Khlghatyan, Jivan; Lemasson, Morgane; Gelao, Barbara; Quarto, Tiziana; Rizzo, Giuseppe; Barbeau, Annie; Lamarre, Claude; ...
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences

    Inhibition of glycogen synthase kinase 3β (GSK3β) is a shared action believed to be involved in the regulation of behavior by psychoactive drugs such as antipsychotics and mood stabilizers. However, little is known about the identity of the substrates through which GSK3...

  • publication . Other literature type . Article . 2013
    Open Access English
    Authors:
    Joshua Kurek; Jane L. Kirk; Derek C. G. Muir; Xiaowa Wang; Marlene S. Evans; John P. Smol;
    Persistent Identifiers
    Publisher: National Academy of Sciences

    We welcome Hrudey’s comments (1) regarding “the most noteworthy findings” of Kurek et al. (2) and have thus focused our response to discuss “several features” of the polycyclic aromatic hydrocarbon (PAH) data (and related dibenzothiophenes, DBTs) from Namur Lake.

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Douhard, Mathieu; Festa-Bianchet, Marco; Pelletier, Fanie;
    Persistent Identifiers
    Publisher: National Academy of Sciences
    Project: NSERC

    Aging, or senescence, is a progressive deterioration of physiological function with age. It leads to age-related declines in reproduction (reproductive senescence) and survival (actuarial senescence) in most organisms. However, senescence patterns can be highly variable...

4,184 research outcomes, page 1 of 419