International audience; 25-30% of families fulfilling the criteria for Hereditary Diffuse Gastric Cancer have germline mutations of the CDH1 (E-cadherin) gene. In light of new data and advancement of technologies a multidisciplinary workshop was convened to discuss gene...

Highlights • Mutations in SH3TC2 cause the demyelinating peripheral neuropathy, CMT type 4C. • The SH3TC2 protein is exclusively expressed in myelinating Schwann cells. • SH3TC2 is expressed late in myelination suggesting a role in myelin maintenance. • The SH3TC2 gene ...

We prove that critical percolation on any quasi-transitive graph of exponential volume growth does not have a unique infinite cluster. This allows us to deduce from earlier results that critical percolation on any graph in this class does not have any infinite clusters....

This work was supported by the Wellcome Trust (I.S.F.), the National Institute for Health Research Cambridge Biomedical Research Centre (S.O’R., I.S.F.), the Bernard Wolfe Health Neuroscience Fund (I.S.F.), the European Research Council (I.S.F.), and the Swiss National ...

ObjectivesTo assess the reporting of study design and characteristics in multi-level degenerative cervical myelopathy (DCM) treated by posterior surgical approaches, and perform a comparison of clinical and radiographic outcomes between different approaches.MethodsA lit...

UK funding includes Cancer Research UK and the UK National Institute for Health Research Biomedical Research Centre. For more information on funding, please look at the article.

This study examines sub-pathological alterations to cattle foot bones from eleven central and western Balkan Neolithic sites (c.61/6000 to 4500 cal BC). Systematic comparisons of bone remodelling in those elements shown to be most directly affected by traction is used t...

Objective: Evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy. Methods: In the 2-year CARE-MS II study (NCT00548405), alemtuzumab-treated patients received 2 courses ...

MYH9‐related disorder diagnosis is still challenging in clinical practice. We analyzed the genetic variants in more than 3,000 patients with a bleeding or platelet disorder and identified 50 patients with a rare variant in MYH9. In the presence of an unclassified platel...

AbstractMultimodal single-cell profiling methods that measure protein expression with oligo-conjugated antibodies hold promise for comprehensive dissection of cellular heterogeneity, yet the resulting protein counts have substantial technical noise that can mask biologi...