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description Publicationkeyboard_double_arrow_right Article , Other literature type 2007Proceedings of the National Academy of Sciences V L, Friesen; A L, Smith; E, Gómez-Díaz; M, Bolton; R W, Furness; J, González-Solís; L R, Monteiro;The importance of sympatric speciation (the evolution of reproductive isolation between codistributed populations) in generating biodiversity is highly controversial. Whereas potential examples of sympatric speciation exist for plants, insects, and fishes, most theoretical models suggest that it requires conditions that are probably not common in nature, and only two possible cases have been described for tetrapods. One mechanism by which it could occur is through allochronic isolation—separation of populations by breeding time.Oceanodroma castro(the Madeiran or band-rumped storm-petrel) is a small seabird that nests on tropical and subtropical islands throughout the Atlantic and Pacific Oceans. In at least five archipelagos, different individuals breed on the same islands in different seasons. We compared variation in five microsatellite loci and the mitochondrial control region among 562O. castrofrom throughout the species' range. We found that sympatric seasonal populations differ genetically within all five archipelagos and have ceased to exchange genes in two. Population and gene trees all indicate that seasonal populations within four of the archipelagos are more closely related to each other than to populations from the same season from other archipelagos; divergence of the fifth sympatric pair is too ancient for reliable inference. Thus, seasonal populations appear to have arisen sympatrically at least four times. This is the first evidence for sympatric speciation by allochrony in a tetrapod, and adds to growing indications that population differentiation and speciation can occur without geographic barriers to gene flow.
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For further information contact us at helpdesk@openaire.eu157 citations 157 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United KingdomSpringer Science and Business Media LLC NIH | Regulators of G Protein S..., NIH | BASIC MECHANISMS OF VIRAL...NIH| Regulators of G Protein Signaling in Yeast ,NIH| BASIC MECHANISMS OF VIRAL AND CHEMICAL CARCINOGENESISRamona Schrage; Anna Lena Schmitz; Evelyn Gaffal; Suvi Annala; Stefan Kehraus; Daniela Wenzel; Katrin M. Büllesbach; Tobias Bald; Asuka Inoue; Yuji Shinjo; Ségolène Galandrin; Naveen Shridhar; Michael Hesse; Manuel Grundmann; Nicole Merten; Thomas H. Charpentier; Matthew K. Martz; Adrian J. Butcher; Tanja Slodczyk; Sylvain Armando; Maike Effern; Yoon Namkung; Laura Jenkins; Velten Horn; Anne Stößel; Harald Dargatz; Daniel Tietze; Diana Imhof; Céline Galés; Christel Drewke; Christa E. Müller; Michael Hölzel; Graeme Milligan; Andrew B. Tobin; Jesus Gomeza; Henrik G. Dohlman; John Sondek; T. Kendall Harden; Michel Bouvier; Stéphane A. Laporte; Junken Aoki; Bernd K. Fleischmann; Klaus Mohr; Gabriele M. König; Thomas Tüting; Evi Kostenis;Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. Using a multifaceted approach we systematically characterize FR as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms and elaborate its molecular mechanism of action. We also use FR to investigate whether inhibition of Gq proteins is an effective post-receptor strategy to target oncogenic signalling, using melanoma as a model system. FR suppresses many of the hallmark features that are central to the malignancy of melanoma cells, thereby providing new opportunities for therapeutic intervention. Just as pertussis toxin is used extensively to probe and inhibit the signalling of Gi/o proteins, we anticipate that FR will at least be its equivalent for investigating the biological relevance of Gq. Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells.
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For further information contact us at helpdesk@openaire.eu325 citations 325 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 3visibility views 3 download downloads 45 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France, Netherlands, Italy, France, NetherlandsSpringer Science and Business Media LLC Ewan C. Goligher; Annemijn H. Jonkman; Jose Dianti; Katerina Vaporidi; Jeremy R. Beitler; Bhakti K. Patel; Takeshi Yoshida; Samir Jaber; Martin Dres; Tommaso Mauri; Giacomo Bellani; Alexandre Demoule; Laurent Brochard; Leo M. A. Heunks;International audience; Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm develops atrophy as a consequence of low respiratory effort and injury in case of excessive effort. The lung and diaphragm-protective mechanical ventilation approach aims to protect both organs simultaneously whenever possible. This review summarizes practical strategies for achieving lung and diaphragm-protective targets at the bedside, focusing on inspiratory and expiratory ventilator settings, monitoring of inspiratory effort or respiratory drive, management of dyssynchrony, and sedation considerations. A number of potential future adjunctive strategies including extracorporeal CO2 removal, partial neuromuscular blockade, and neuromuscular stimulation are also discussed. While clinical trials to confirm the benefit of these approaches are awaited, clinicians should become familiar with assessing and managing patients' respiratory effort, based on existing physiological principles. To protect the lung and the diaphragm, ventilation and sedation might be applied to avoid excessively weak or very strong respiratory efforts and patient-ventilator dysynchrony.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu100 citations 100 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 SpainInforma UK Limited Authors: Nolla Solé, Joan Miquel; Martín-Sánchez, Esperanza; Llamas, Pilar; Manero, Javier; +6 AuthorsNolla Solé, Joan Miquel; Martín-Sánchez, Esperanza; Llamas, Pilar; Manero, Javier; Rodríguez de la Serna, Arturo; Fernández-Miera, Manuel Francisco; Rodríguez, Mercedes; López, José Manuel; Ivanova, Aleksandra; Aragon, Belén;doi: 10.2147/tcrm.s112062
handle: 10668/11021 , 20.500.12530/32216 , 2445/128137
pmid: 28356746
pmc: PMC5360410
doi: 10.2147/tcrm.s112062
handle: 10668/11021 , 20.500.12530/32216 , 2445/128137
pmid: 28356746
pmc: PMC5360410
Joan Miquel Nolla,1 Esperanza Martín,2 Pilar Llamas,3 Javier Manero,4 Arturo Rodríguez de la Serna,5 Manuel Francisco Fernández-Miera,6 Mercedes Rodríguez,6 José Manuel López,7 Alexandra Ivanova,8 Belén Aragón9 1Rheumatology Department, IDIBELL-Hospital Universitari de Bellvitge, Barcelona, 2Hospital Universitario de Getafe, Madrid, 3Hospital Universitario Fundación Jiménez Díaz, Madrid, 4Hospital Universitario Miguel Servet, Zaragoza, 5Hospital de la Santa Creu i Sant Pau, Barcelona, 6Hospital Universitario Marqués de Valdecilla, Santander, 7Hospital Universitario Virgen del Rocío, Sevilla, 8Max Weber Institute, Madrid, 9MSD, Madrid, Spain Objective: To estimate the unit costs of administering intravenous (IV) biological agents in day hospitals (DHs) in the Spanish National Health System.Patients and methods: Data were obtained from 188 patients with rheumatoid arthritis, collected from nine DHs, receiving one of the following IV therapies: infliximab (n=48), rituximab (n=38), abatacept (n=41), or tocilizumab (n=61). The fieldwork was carried out between March 2013 and March 2014. The following three groups of costs were considered: 1) structural costs, 2) material costs, and 3) staff costs. Staff costs were considered a fixed cost and were estimated according to the DH theoretical level of activity, which includes, as well as personal care of each patient, the DH general activities (complete imputation method, CIM). In addition, an alternative calculation was performed, in which the staff costs were considered a variable cost imputed according to the time spent on direct care (partial imputation method, PIM). All costs were expressed in euros for the reference year 2014.Results: The average total cost was €146.12 per infusion (standard deviation [SD] ±87.11; CIM) and €29.70 per infusion (SD ±11.42; PIM). The structure-related costs per infusion varied between €2.23 and €62.35 per patient and DH; the cost of consumables oscillated between €3.48 and €20.34 per patient and DH. In terms of the care process, the average difference between the shortest and the longest time taken by different hospitals to administer an IV biological therapy was 113 minutes.Conclusion: The average total cost of infusion was less than that normally used in models of economic evaluation coming from secondary sources. This cost is even less when the staff costs are imputed according to the PIM. A high degree of variability was observed between different DHs in the cost of the consumables, in the structure-related costs, and in those of the care process. Keywords: day hospitals, rheumatoid arthritis, intravenous biological agents, unit cost of infusion, variability, care process
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017 . 2019License: CC BY NCRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARISalud-ANDALUCIA. Respositorio Institucional de Salud de Andalucia.Article . 2017License: CC BY NCTherapeutics and Clinical Risk Management; DOAJ-ArticlesArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!visibility 60visibility views 60 download downloads 80 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017 . 2019License: CC BY NCRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARISalud-ANDALUCIA. Respositorio Institucional de Salud de Andalucia.Article . 2017License: CC BY NCTherapeutics and Clinical Risk Management; DOAJ-ArticlesArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Denmark, France, Sweden, France, United Kingdom, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, NetherlandsWiley NIH | Mayo Heart Failure Region..., NIH | SALsalate to Improve Exer..., EC | inHForm +10 projectsNIH| Mayo Heart Failure Regional Clinical Center ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,EC| inHForm ,NIH| Mid Atlantic Heart Failure Network ,NIH| UCLA Clinical Translational Science Institute ,NIH| Heart Failure Clinical Trials Network ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Genomics of Cardiac Arrhythmias ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| New England, New York and Quebec Regional Clinical Center ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData HeartR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Abbas Dehghan; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Gunnar Engström; Tõnu Esko; Ghazaleh Fatemifar; Stephan B. Felix; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Sahar Ghasemi; Vilmantas Giedraitis; John S. Gottdiener; Stefan Gross; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Bruce M. Psaty; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Harvey D. White; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS; ESC Heart Fa... arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021VBN; ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISArticle . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS; ESC Heart Fa... arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021VBN; ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISArticle . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 United KingdomElsevier BV UKRI | The International Centre ..., EC | CLASSUKRI| The International Centre for Language and Communicative Development ,EC| CLASSAmbridge, Ben; Maitreyee, Ramya; Tatsumi, Tomoko; Doherty, Laura; Zicherman, Shira; Pedro, Pedro Mateo; Bannard, Colin; Samanta, Soumitra; McCauley, Stewart; Arnon, Inbal; Bekman, Dani; Efrati, Amir; Berman, Ruth; Narasimhan, Bhuvana; Sharma, Dipti Misra; Nair, Rukmini Bhaya; Fukumura, Kumiko; Campbell, Seth; Pye, Clifton; Pixabaj, Sindy Fabiola Can; Pelíz, Mario Marroquín; Mendoza, Margarita Julajuj;This preregistered study tested three theoretical proposals for how children form productive yet restricted linguistic generalizations, avoiding errors such as *The clown laughed the man, across three age groups (5–6 years, 9–10 years, adults) and five languages (English, Japanese, Hindi, Hebrew and K'iche'). Participants rated, on a five-point scale, correct and ungrammatical sentences describing events of causation (e.g., *Someone laughed the man; Someone made the man laugh; Someone broke the truck; ?Someone made the truck break). The verb-semantics hypothesis predicts that, for all languages, by-verb differences in acceptability ratings will be predicted by the extent to which the causing and caused event (e.g., amusing and laughing) merge conceptually into a single event (as rated by separate groups of adult participants). The entrenchment and preemption hypotheses predict, for all languages, that by-verb differences in acceptability ratings will be predicted by, respectively, the verb's relative overall frequency, and frequency in nearly-synonymous constructions (e.g., X made Y laugh for *Someone laughed the man). Analysis using mixed effects models revealed that entrenchment/preemption effects (which could not be distinguished due to collinearity) were observed for all age groups and all languages except K'iche', which suffered from a thin corpus and showed only preemption sporadically. All languages showed effects of event-merge semantics, except K'iche' which showed only effects of supplementary semantic predictors. We end by presenting a computational model which successfully simulates this pattern of results in a single discriminative-learning mechanism, achieving by-verb correlations of around r = 0.75 with human judgment data.
Europe PubMed Centra... arrow_drop_down The University of Manchester - Institutional Repository; CognitionOther literature type . Article . 2020License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 5visibility views 5 download downloads 12 Powered bymore_vert Europe PubMed Centra... arrow_drop_down The University of Manchester - Institutional Repository; CognitionOther literature type . Article . 2020License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014Informa UK Limited Kiss, Szilárd; Liu,Ying; Brown,Joseph; Holekamp,Nancy; Almony,Arghavan; Campbell,Joanna; Kowalski,Jonathan;Szilárd Kiss,1 Ying Liu,2 Joseph Brown,3 Nancy M Holekamp,4,5 Arghavan Almony,6 Joanna Campbell,2 Jonathan W Kowalski2 1Weill Cornell Medical College, New York, NY; 2Allergan, Inc., Irvine, CA; 3IMS Health, Woodland Hills, CA; 4Pepose Vision Institute, Chesterfield, MO; 5Washington University School of Medicine, St Louis, MO; 6Carolina Eye Associates, Southern Pines, NC, USA Purpose: To examine the utilization of bevacizumab and ranibizumab and disease monitoring in patients with branch or central retinal vein occlusion (BRVO/CRVO) or diabetic macular edema (DME) in clinical practice.Patients and methods: This retrospective claims analysis included newly diagnosed patients with one or more bevacizumab or ranibizumab injections. Bevacizumab or ranibizumab utilization was assessed by year of first injection: 2008–2010 cohorts (12-month follow-up), January to June 2011 cohort (6-month follow-up). The main outcome measures were mean annual numbers of injections, ophthalmologist visits and optical coherence tomography examinations, and proportion of patients with additional laser or intravitreal triamcinolone (IVTA) use.Results: A total of 885 BRVO, 611 CRVO, and 2,733 DME patients treated with bevacizumab were included, with too few ranibizumab-treated patients for meaningful analysis. Across the 2008, 2009, and 2010 cohorts, mean annual numbers of bevacizumab injections increased, but remained low (BRVO 2.5, 3.1, 3.3; CRVO 3.1, 3.1, 3.5; and DME 2.2, 2.5, 3.6, respectively); mean ophthalmologist visits ranged between 4.4 and 6.5, and mean optical coherence tomography examinations ranged between 3.1 and 3.9 across all conditions. A total of 42.0% of BRVO, 16.5% of CRVO, and 57.7% of DME patients received additional laser or IVTA therapy. The number of bevacizumab injections was positively associated with laser use in BRVO (3.3 versus 2.9, P<0.03), and with laser or IVTA use in DME (laser, 3.3 versus 2.7, P<0.03; IVTA, 3.3 versus 3.0, P<0.05).Conclusion: During the study period (2008–2011), bevacizumab was the main anti-VEGF therapy used in clinical practice for BRVO, CRVO, and DME. Patients treated with bevacizumab were monitored less frequently and received fewer injections than patients in major clinical trials of ranibizumab. Keywords: anti-vascular endothelial growth factor, bevacizumab, ranibizumab, diabetic macular edema, retinal vein occlusion, intravitreal
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu90 citations 90 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015Veterinary World Narinder, Singh; G S, Dhaliwal; V S, Malik; D, Dadarwal; M, Honparkhe; S, Singhal; P S, Brar;Aim: To evaluate the follicular dynamics, superovulatory response, and embryo recovery following superstimulatory treatment initiated at estradiol-17β induced follicular wave emergence and its comparison with conventional superstimulatory protocol in buffaloes. Materials and Methods: Six normal cycling pluriparous buffaloes, lactating, 90-180 days post-partum, and weighing between 500 and 660 kg were superstimulated twice with a withdrawal period of 35 days in between two treatments. In superstimulation protocol-1 (estradiol group) buffaloes were administered estradiol-17β (2 mg, i.m.) and eazibreed controlled internal drug release (CIDR) was inserted intravaginally (day=0) at the random stage of the estrous cycle. On the day 4, buffaloes were superstimulated using follicle stimulating hormone (FSH) 400 mg, divided into 10 tapering doses given at 12 hourly intervals. Prostaglandin F2α analogs (PGF2α) was administered at day 7.5 and day 8, and CIDR was removed with the second PGF2α injection. In superstimulation protocol - 2 (conventional group) buffaloes were superstimulated on the 10th day of the estrous cycle with same FSH dose regimen and similar timings for PGF2α injections. In both groups, half of the buffaloes were treated with luteinizing hormone (LH) 25 mg and other half with 100 ug buserelin; gonadotrophin releasing hormone (GnRH) analog at 12 h after the end of FSH treatment. All buffaloes in both protocols were inseminated twice at 12 and 24 h of LH/GnRH treatment. Daily ultrasonography was performed to record the size and number of follicles and superovulatory response. Results: Significantly higher number of small follicles (8 mm), corpora lutea, and transferable embryos was higher in buffaloes superstimulated at estradiol-induced follicular wave compared to the conventional protocol: Further the percentage of transferable embryos was significantly higher in buffaloes administered with LH compared to GnRH.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.14202/vetworld.2015.983-988&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Public Library of Science (PLoS) NIH | Vermont Genetics Network-...NIH| Vermont Genetics Network-Vermont INBREDaniel Penados; José P. Pineda; Elisa Laparra-Ruiz; Manuel F. Galván; Anna M. Schmoker; Bryan A. Ballif; M. Carlota Monroy; Lori Stevens;Chagas disease is mainly transmitted by triatomine insect vectors that feed on vertebrate blood. The disease has complex domiciliary infestation patterns and parasite transmission dynamics, influenced by biological, ecological, and socioeconomic factors. In this context, feeding patterns have been used to understand vector movement and transmission risk. Recently, a new technique using Liquid chromatography tandem mass spectrometry (LC-MS/MS) targeting hemoglobin peptides has showed excellent results for understanding triatomines’ feeding patterns. The aim of this study was to further develop the automated computational analysis pipeline for peptide sequence taxonomic identification, enhancing the ability to analyze large datasets data. We then used the enhanced pipeline to evaluate the feeding patterns of Triatoma dimidiata, along with domiciliary infestation risk variables, such as unkempt piles of firewood or construction material, cracks in bajareque and adobe walls and intradomiciliary animals. Our new python scripts were able to detect blood meal sources in 100% of the bugs analyzed and identified nine different species of blood meal sources. Human, chicken, and dog were the main blood sources found in 78.7%, 50.4% and 44.8% of the bugs, respectively. In addition, 14% of the bugs feeding on chicken and 15% of those feeding on dogs were captured in houses with no evidence of those animals being present. This suggests a high mobility among ecotopes and houses. Two of the three main blood sources, dog and chicken, were significantly (p < 0.05) affected by domiciliary infestation risk variables, including cracks in walls, construction material and birds sleeping in the intradomicile. This suggests that these variables are important for maintaining reproducing Triatoma dimidiata populations and that it is critical to mitigate these variables in all the houses of a village for effective control of these mobile vectors.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0262552&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0262552&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Radiological Society of North America (RSNA) Raman Dutt; Dylan Mendonca; Huai Ming Phen; Samuel Broida; Marzyeh Ghassemi; Judy Gichoya; Imon Banerjee; Tim Yoon; Hari Trivedi;PURPOSE: To develop an end-to-end pipeline to localize and identify cervical spine hardware brands on routine cervical spine radiographs. MATERIALS AND METHODS: In this single-center retrospective study, patients who received cervical spine implants between 2014 and 2018 were identified. Information on the implant model was retrieved from the surgical notes. The dataset was filtered for implants present in at least three patients, which yielded five anterior and five posterior hardware models for classification. Images for training were manually annotated with bounding boxes for anterior and posterior hardware. An object detection model was trained and implemented to localize hardware on the remaining images. An image classification model was then trained to differentiate between five anterior and five posterior hardware models. Model performance was evaluated on a holdout test set with 1000 iterations of bootstrapping. RESULTS: A total of 984 patients (mean age, 62 years ± 12 [standard deviation]; 525 women) were included for model training, validation, and testing. The hardware localization model achieved an intersection over union of 86.8% and an F1 score of 94.9%. For brand classification, an F1 score, sensitivity, and specificity of 98.7% ± 0.5, 98.7% ± 0.5, and 99.2% ± 0.3, respectively, were attained for anterior hardware, with values of 93.5% ± 2.0, 92.6% ± 2.0, and 96.1% ± 2.0, respectively, attained for posterior hardware. CONCLUSION: The developed pipeline was able to accurately localize and classify brands of hardware implants using a weakly supervised learning framework. Keywords: Spine, Convolutional Neural Network, Deep Learning Algorithms, Machine Learning Algorithms, Prostheses, Semisupervised Learning Supplemental material is available for this article. © RSNA, 2022 See also commentary by Huisman and Lessmann in this issue.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2007Proceedings of the National Academy of Sciences V L, Friesen; A L, Smith; E, Gómez-Díaz; M, Bolton; R W, Furness; J, González-Solís; L R, Monteiro;The importance of sympatric speciation (the evolution of reproductive isolation between codistributed populations) in generating biodiversity is highly controversial. Whereas potential examples of sympatric speciation exist for plants, insects, and fishes, most theoretical models suggest that it requires conditions that are probably not common in nature, and only two possible cases have been described for tetrapods. One mechanism by which it could occur is through allochronic isolation—separation of populations by breeding time.Oceanodroma castro(the Madeiran or band-rumped storm-petrel) is a small seabird that nests on tropical and subtropical islands throughout the Atlantic and Pacific Oceans. In at least five archipelagos, different individuals breed on the same islands in different seasons. We compared variation in five microsatellite loci and the mitochondrial control region among 562O. castrofrom throughout the species' range. We found that sympatric seasonal populations differ genetically within all five archipelagos and have ceased to exchange genes in two. Population and gene trees all indicate that seasonal populations within four of the archipelagos are more closely related to each other than to populations from the same season from other archipelagos; divergence of the fifth sympatric pair is too ancient for reliable inference. Thus, seasonal populations appear to have arisen sympatrically at least four times. This is the first evidence for sympatric speciation by allochrony in a tetrapod, and adds to growing indications that population differentiation and speciation can occur without geographic barriers to gene flow.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.0700446104&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu157 citations 157 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United KingdomSpringer Science and Business Media LLC NIH | Regulators of G Protein S..., NIH | BASIC MECHANISMS OF VIRAL...NIH| Regulators of G Protein Signaling in Yeast ,NIH| BASIC MECHANISMS OF VIRAL AND CHEMICAL CARCINOGENESISRamona Schrage; Anna Lena Schmitz; Evelyn Gaffal; Suvi Annala; Stefan Kehraus; Daniela Wenzel; Katrin M. Büllesbach; Tobias Bald; Asuka Inoue; Yuji Shinjo; Ségolène Galandrin; Naveen Shridhar; Michael Hesse; Manuel Grundmann; Nicole Merten; Thomas H. Charpentier; Matthew K. Martz; Adrian J. Butcher; Tanja Slodczyk; Sylvain Armando; Maike Effern; Yoon Namkung; Laura Jenkins; Velten Horn; Anne Stößel; Harald Dargatz; Daniel Tietze; Diana Imhof; Céline Galés; Christel Drewke; Christa E. Müller; Michael Hölzel; Graeme Milligan; Andrew B. Tobin; Jesus Gomeza; Henrik G. Dohlman; John Sondek; T. Kendall Harden; Michel Bouvier; Stéphane A. Laporte; Junken Aoki; Bernd K. Fleischmann; Klaus Mohr; Gabriele M. König; Thomas Tüting; Evi Kostenis;Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. Using a multifaceted approach we systematically characterize FR as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms and elaborate its molecular mechanism of action. We also use FR to investigate whether inhibition of Gq proteins is an effective post-receptor strategy to target oncogenic signalling, using melanoma as a model system. FR suppresses many of the hallmark features that are central to the malignancy of melanoma cells, thereby providing new opportunities for therapeutic intervention. Just as pertussis toxin is used extensively to probe and inhibit the signalling of Gi/o proteins, we anticipate that FR will at least be its equivalent for investigating the biological relevance of Gq. Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms10156&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu325 citations 325 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 3visibility views 3 download downloads 45 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms10156&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France, Netherlands, Italy, France, NetherlandsSpringer Science and Business Media LLC Ewan C. Goligher; Annemijn H. Jonkman; Jose Dianti; Katerina Vaporidi; Jeremy R. Beitler; Bhakti K. Patel; Takeshi Yoshida; Samir Jaber; Martin Dres; Tommaso Mauri; Giacomo Bellani; Alexandre Demoule; Laurent Brochard; Leo M. A. Heunks;International audience; Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm develops atrophy as a consequence of low respiratory effort and injury in case of excessive effort. The lung and diaphragm-protective mechanical ventilation approach aims to protect both organs simultaneously whenever possible. This review summarizes practical strategies for achieving lung and diaphragm-protective targets at the bedside, focusing on inspiratory and expiratory ventilator settings, monitoring of inspiratory effort or respiratory drive, management of dyssynchrony, and sedation considerations. A number of potential future adjunctive strategies including extracorporeal CO2 removal, partial neuromuscular blockade, and neuromuscular stimulation are also discussed. While clinical trials to confirm the benefit of these approaches are awaited, clinicians should become familiar with assessing and managing patients' respiratory effort, based on existing physiological principles. To protect the lung and the diaphragm, ventilation and sedation might be applied to avoid excessively weak or very strong respiratory efforts and patient-ventilator dysynchrony.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu100 citations 100 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00134-020-06288-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 SpainInforma UK Limited Authors: Nolla Solé, Joan Miquel; Martín-Sánchez, Esperanza; Llamas, Pilar; Manero, Javier; +6 AuthorsNolla Solé, Joan Miquel; Martín-Sánchez, Esperanza; Llamas, Pilar; Manero, Javier; Rodríguez de la Serna, Arturo; Fernández-Miera, Manuel Francisco; Rodríguez, Mercedes; López, José Manuel; Ivanova, Aleksandra; Aragon, Belén;doi: 10.2147/tcrm.s112062
handle: 10668/11021 , 20.500.12530/32216 , 2445/128137
pmid: 28356746
pmc: PMC5360410
doi: 10.2147/tcrm.s112062
handle: 10668/11021 , 20.500.12530/32216 , 2445/128137
pmid: 28356746
pmc: PMC5360410
Joan Miquel Nolla,1 Esperanza Martín,2 Pilar Llamas,3 Javier Manero,4 Arturo Rodríguez de la Serna,5 Manuel Francisco Fernández-Miera,6 Mercedes Rodríguez,6 José Manuel López,7 Alexandra Ivanova,8 Belén Aragón9 1Rheumatology Department, IDIBELL-Hospital Universitari de Bellvitge, Barcelona, 2Hospital Universitario de Getafe, Madrid, 3Hospital Universitario Fundación Jiménez Díaz, Madrid, 4Hospital Universitario Miguel Servet, Zaragoza, 5Hospital de la Santa Creu i Sant Pau, Barcelona, 6Hospital Universitario Marqués de Valdecilla, Santander, 7Hospital Universitario Virgen del Rocío, Sevilla, 8Max Weber Institute, Madrid, 9MSD, Madrid, Spain Objective: To estimate the unit costs of administering intravenous (IV) biological agents in day hospitals (DHs) in the Spanish National Health System.Patients and methods: Data were obtained from 188 patients with rheumatoid arthritis, collected from nine DHs, receiving one of the following IV therapies: infliximab (n=48), rituximab (n=38), abatacept (n=41), or tocilizumab (n=61). The fieldwork was carried out between March 2013 and March 2014. The following three groups of costs were considered: 1) structural costs, 2) material costs, and 3) staff costs. Staff costs were considered a fixed cost and were estimated according to the DH theoretical level of activity, which includes, as well as personal care of each patient, the DH general activities (complete imputation method, CIM). In addition, an alternative calculation was performed, in which the staff costs were considered a variable cost imputed according to the time spent on direct care (partial imputation method, PIM). All costs were expressed in euros for the reference year 2014.Results: The average total cost was €146.12 per infusion (standard deviation [SD] ±87.11; CIM) and €29.70 per infusion (SD ±11.42; PIM). The structure-related costs per infusion varied between €2.23 and €62.35 per patient and DH; the cost of consumables oscillated between €3.48 and €20.34 per patient and DH. In terms of the care process, the average difference between the shortest and the longest time taken by different hospitals to administer an IV biological therapy was 113 minutes.Conclusion: The average total cost of infusion was less than that normally used in models of economic evaluation coming from secondary sources. This cost is even less when the staff costs are imputed according to the PIM. A high degree of variability was observed between different DHs in the cost of the consumables, in the structure-related costs, and in those of the care process. Keywords: day hospitals, rheumatoid arthritis, intravenous biological agents, unit cost of infusion, variability, care process
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017 . 2019License: CC BY NCRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARISalud-ANDALUCIA. Respositorio Institucional de Salud de Andalucia.Article . 2017License: CC BY NCTherapeutics and Clinical Risk Management; DOAJ-ArticlesArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!visibility 60visibility views 60 download downloads 80 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017 . 2019License: CC BY NCRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTARISalud-ANDALUCIA. Respositorio Institucional de Salud de Andalucia.Article . 2017License: CC BY NCTherapeutics and Clinical Risk Management; DOAJ-ArticlesArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Denmark, France, Sweden, France, United Kingdom, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, NetherlandsWiley NIH | Mayo Heart Failure Region..., NIH | SALsalate to Improve Exer..., EC | inHForm +10 projectsNIH| Mayo Heart Failure Regional Clinical Center ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,EC| inHForm ,NIH| Mid Atlantic Heart Failure Network ,NIH| UCLA Clinical Translational Science Institute ,NIH| Heart Failure Clinical Trials Network ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Genomics of Cardiac Arrhythmias ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| New England, New York and Quebec Regional Clinical Center ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData HeartR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Abbas Dehghan; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Gunnar Engström; Tõnu Esko; Ghazaleh Fatemifar; Stephan B. Felix; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Sahar Ghasemi; Vilmantas Giedraitis; John S. Gottdiener; Stefan Gross; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Bruce M. Psaty; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Harvey D. White; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS; ESC Heart Fa... arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021VBN; ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISArticle . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS; ESC Heart Fa... arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021VBN; ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISArticle . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ehf2.13517&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 United KingdomElsevier BV UKRI | The International Centre ..., EC | CLASSUKRI| The International Centre for Language and Communicative Development ,EC| CLASSAmbridge, Ben; Maitreyee, Ramya; Tatsumi, Tomoko; Doherty, Laura; Zicherman, Shira; Pedro, Pedro Mateo; Bannard, Colin; Samanta, Soumitra; McCauley, Stewart; Arnon, Inbal; Bekman, Dani; Efrati, Amir; Berman, Ruth; Narasimhan, Bhuvana; Sharma, Dipti Misra; Nair, Rukmini Bhaya; Fukumura, Kumiko; Campbell, Seth; Pye, Clifton; Pixabaj, Sindy Fabiola Can; Pelíz, Mario Marroquín; Mendoza, Margarita Julajuj;This preregistered study tested three theoretical proposals for how children form productive yet restricted linguistic generalizations, avoiding errors such as *The clown laughed the man, across three age groups (5–6 years, 9–10 years, adults) and five languages (English, Japanese, Hindi, Hebrew and K'iche'). Participants rated, on a five-point scale, correct and ungrammatical sentences describing events of causation (e.g., *Someone laughed the man; Someone made the man laugh; Someone broke the truck; ?Someone made the truck break). The verb-semantics hypothesis predicts that, for all languages, by-verb differences in acceptability ratings will be predicted by the extent to which the causing and caused event (e.g., amusing and laughing) merge conceptually into a single event (as rated by separate groups of adult participants). The entrenchment and preemption hypotheses predict, for all languages, that by-verb differences in acceptability ratings will be predicted by, respectively, the verb's relative overall frequency, and frequency in nearly-synonymous constructions (e.g., X made Y laugh for *Someone laughed the man). Analysis using mixed effects models revealed that entrenchment/preemption effects (which could not be distinguished due to collinearity) were observed for all age groups and all languages except K'iche', which suffered from a thin corpus and showed only preemption sporadically. All languages showed effects of event-merge semantics, except K'iche' which showed only effects of supplementary semantic predictors. We end by presenting a computational model which successfully simulates this pattern of results in a single discriminative-learning mechanism, achieving by-verb correlations of around r = 0.75 with human judgment data.
Europe PubMed Centra... arrow_drop_down The University of Manchester - Institutional Repository; CognitionOther literature type . Article . 2020License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cognition.2020.104310&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 5visibility views 5 download downloads 12 Powered bymore_vert Europe PubMed Centra... arrow_drop_down The University of Manchester - Institutional Repository; CognitionOther literature type . Article . 2020License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014Informa UK Limited Kiss, Szilárd; Liu,Ying; Brown,Joseph; Holekamp,Nancy; Almony,Arghavan; Campbell,Joanna; Kowalski,Jonathan;Szilárd Kiss,1 Ying Liu,2 Joseph Brown,3 Nancy M Holekamp,4,5 Arghavan Almony,6 Joanna Campbell,2 Jonathan W Kowalski2 1Weill Cornell Medical College, New York, NY; 2Allergan, Inc., Irvine, CA; 3IMS Health, Woodland Hills, CA; 4Pepose Vision Institute, Chesterfield, MO; 5Washington University School of Medicine, St Louis, MO; 6Carolina Eye Associates, Southern Pines, NC, USA Purpose: To examine the utilization of bevacizumab and ranibizumab and disease monitoring in patients with branch or central retinal vein occlusion (BRVO/CRVO) or diabetic macular edema (DME) in clinical practice.Patients and methods: This retrospective claims analysis included newly diagnosed patients with one or more bevacizumab or ranibizumab injections. Bevacizumab or ranibizumab utilization was assessed by year of first injection: 2008–2010 cohorts (12-month follow-up), January to June 2011 cohort (6-month follow-up). The main outcome measures were mean annual numbers of injections, ophthalmologist visits and optical coherence tomography examinations, and proportion of patients with additional laser or intravitreal triamcinolone (IVTA) use.Results: A total of 885 BRVO, 611 CRVO, and 2,733 DME patients treated with bevacizumab were included, with too few ranibizumab-treated patients for meaningful analysis. Across the 2008, 2009, and 2010 cohorts, mean annual numbers of bevacizumab injections increased, but remained low (BRVO 2.5, 3.1, 3.3; CRVO 3.1, 3.1, 3.5; and DME 2.2, 2.5, 3.6, respectively); mean ophthalmologist visits ranged between 4.4 and 6.5, and mean optical coherence tomography examinations ranged between 3.1 and 3.9 across all conditions. A total of 42.0% of BRVO, 16.5% of CRVO, and 57.7% of DME patients received additional laser or IVTA therapy. The number of bevacizumab injections was positively associated with laser use in BRVO (3.3 versus 2.9, P<0.03), and with laser or IVTA use in DME (laser, 3.3 versus 2.7, P<0.03; IVTA, 3.3 versus 3.0, P<0.05).Conclusion: During the study period (2008–2011), bevacizumab was the main anti-VEGF therapy used in clinical practice for BRVO, CRVO, and DME. Patients treated with bevacizumab were monitored less frequently and received fewer injections than patients in major clinical trials of ranibizumab. Keywords: anti-vascular endothelial growth factor, bevacizumab, ranibizumab, diabetic macular edema, retinal vein occlusion, intravitreal
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2147/opth.s60893&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu90 citations 90 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2147/opth.s60893&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015Veterinary World Narinder, Singh; G S, Dhaliwal; V S, Malik; D, Dadarwal; M, Honparkhe; S, Singhal; P S, Brar;Aim: To evaluate the follicular dynamics, superovulatory response, and embryo recovery following superstimulatory treatment initiated at estradiol-17β induced follicular wave emergence and its comparison with conventional superstimulatory protocol in buffaloes. Materials and Methods: Six normal cycling pluriparous buffaloes, lactating, 90-180 days post-partum, and weighing between 500 and 660 kg were superstimulated twice with a withdrawal period of 35 days in between two treatments. In superstimulation protocol-1 (estradiol group) buffaloes were administered estradiol-17β (2 mg, i.m.) and eazibreed controlled internal drug release (CIDR) was inserted intravaginally (day=0) at the random stage of the estrous cycle. On the day 4, buffaloes were superstimulated using follicle stimulating hormone (FSH) 400 mg, divided into 10 tapering doses given at 12 hourly intervals. Prostaglandin F2α analogs (PGF2α) was administered at day 7.5 and day 8, and CIDR was removed with the second PGF2α injection. In superstimulation protocol - 2 (conventional group) buffaloes were superstimulated on the 10th day of the estrous cycle with same FSH dose regimen and similar timings for PGF2α injections. In both groups, half of the buffaloes were treated with luteinizing hormone (LH) 25 mg and other half with 100 ug buserelin; gonadotrophin releasing hormone (GnRH) analog at 12 h after the end of FSH treatment. All buffaloes in both protocols were inseminated twice at 12 and 24 h of LH/GnRH treatment. Daily ultrasonography was performed to record the size and number of follicles and superovulatory response. Results: Significantly higher number of small follicles (8 mm), corpora lutea, and transferable embryos was higher in buffaloes superstimulated at estradiol-induced follicular wave compared to the conventional protocol: Further the percentage of transferable embryos was significantly higher in buffaloes administered with LH compared to GnRH.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.14202/vetworld.2015.983-988&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.14202/vetworld.2015.983-988&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Public Library of Science (PLoS) NIH | Vermont Genetics Network-...NIH| Vermont Genetics Network-Vermont INBREDaniel Penados; José P. Pineda; Elisa Laparra-Ruiz; Manuel F. Galván; Anna M. Schmoker; Bryan A. Ballif; M. Carlota Monroy; Lori Stevens;Chagas disease is mainly transmitted by triatomine insect vectors that feed on vertebrate blood. The disease has complex domiciliary infestation patterns and parasite transmission dynamics, influenced by biological, ecological, and socioeconomic factors. In this context, feeding patterns have been used to understand vector movement and transmission risk. Recently, a new technique using Liquid chromatography tandem mass spectrometry (LC-MS/MS) targeting hemoglobin peptides has showed excellent results for understanding triatomines’ feeding patterns. The aim of this study was to further develop the automated computational analysis pipeline for peptide sequence taxonomic identification, enhancing the ability to analyze large datasets data. We then used the enhanced pipeline to evaluate the feeding patterns of Triatoma dimidiata, along with domiciliary infestation risk variables, such as unkempt piles of firewood or construction material, cracks in bajareque and adobe walls and intradomiciliary animals. Our new python scripts were able to detect blood meal sources in 100% of the bugs analyzed and identified nine different species of blood meal sources. Human, chicken, and dog were the main blood sources found in 78.7%, 50.4% and 44.8% of the bugs, respectively. In addition, 14% of the bugs feeding on chicken and 15% of those feeding on dogs were captured in houses with no evidence of those animals being present. This suggests a high mobility among ecotopes and houses. Two of the three main blood sources, dog and chicken, were significantly (p < 0.05) affected by domiciliary infestation risk variables, including cracks in walls, construction material and birds sleeping in the intradomicile. This suggests that these variables are important for maintaining reproducing Triatoma dimidiata populations and that it is critical to mitigate these variables in all the houses of a village for effective control of these mobile vectors.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0262552&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0262552&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Radiological Society of North America (RSNA) Raman Dutt; Dylan Mendonca; Huai Ming Phen; Samuel Broida; Marzyeh Ghassemi; Judy Gichoya; Imon Banerjee; Tim Yoon; Hari Trivedi;PURPOSE: To develop an end-to-end pipeline to localize and identify cervical spine hardware brands on routine cervical spine radiographs. MATERIALS AND METHODS: In this single-center retrospective study, patients who received cervical spine implants between 2014 and 2018 were identified. Information on the implant model was retrieved from the surgical notes. The dataset was filtered for implants present in at least three patients, which yielded five anterior and five posterior hardware models for classification. Images for training were manually annotated with bounding boxes for anterior and posterior hardware. An object detection model was trained and implemented to localize hardware on the remaining images. An image classification model was then trained to differentiate between five anterior and five posterior hardware models. Model performance was evaluated on a holdout test set with 1000 iterations of bootstrapping. RESULTS: A total of 984 patients (mean age, 62 years ± 12 [standard deviation]; 525 women) were included for model training, validation, and testing. The hardware localization model achieved an intersection over union of 86.8% and an F1 score of 94.9%. For brand classification, an F1 score, sensitivity, and specificity of 98.7% ± 0.5, 98.7% ± 0.5, and 99.2% ± 0.3, respectively, were attained for anterior hardware, with values of 93.5% ± 2.0, 92.6% ± 2.0, and 96.1% ± 2.0, respectively, attained for posterior hardware. CONCLUSION: The developed pipeline was able to accurately localize and classify brands of hardware implants using a weakly supervised learning framework. Keywords: Spine, Convolutional Neural Network, Deep Learning Algorithms, Machine Learning Algorithms, Prostheses, Semisupervised Learning Supplemental material is available for this article. © RSNA, 2022 See also commentary by Huisman and Lessmann in this issue.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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