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96 Research products, page 1 of 10

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  • Open Access English
    Authors: 
    Xiao-Fei Kong; Rubén Martínez-Barricarte; J. Kennedy; Federico Mele; Tomi Lazarov; Elissa K. Deenick; Cindy S. Ma; Gaëlle Breton; Kimberly Lucero; David Langlais; +31 more
    Project: EC | PREDICT (323183), NIH | A genetic dissection of M... (5R01AI089970-02), NIH | Nramp1 in macrophage defe... (5R01AI035237-12), NIH | Transforming Translationa... (3UL1TR000043-07S1), NIH | Genome-Wide Dissection of... (5R37AI095983-07), NIH | Clinical Core (1U19AI118626-01), SNSF | Studies on T cell activat... (170213), ANR | GENMSMD (ANR-16-CE17-0005), ANR | IFNGPHOX (ANR-13-ISV3-0001)

    Human inborn errors of IFN-γ immunity underlie mycobacterial diseases. We describe patients with Mycobacterium bovis (BCG) disease who are homozygous for loss-of-function mutations of SPPL2A. This gene encodes a transmembrane protease that degrades the N-terminal fragment (NTF) of CD74 (HLA invariant chain) in antigen-presenting cells. The CD74 NTF therefore accumulates in the HLA class II+ myeloid and lymphoid cells of SPPL2a-deficient patients. This toxic fragment selectively depletes IL-12- and IL-23-producing CD1c+ conventional dendritic cells (cDC2s) and their circulating progenitors. Moreover, SPPL2a-deficient memory TH1* cells selectively fail to produce IFN-γ when stimulated with mycobacterial antigens in vitro. Finally, Sppl2a–/– mice lack cDC2s, have CD4+ T cells that produce small amounts of IFN-γ after BCG infection, and are highly susceptible to infection with BCG or Mycobacterium tuberculosis. These findings suggest that inherited SPPL2a deficiency in humans underlies mycobacterial disease by decreasing the numbers of cDC2s and impairing IFN-γ production by mycobacterium-specific memory TH1* cells. Primary immunodeficiency can predispose patients to mycobacterial disease. Casanova and colleagues identify novel human mutations in the enzyme SPPL2A that result in selective accumulation of CD74 in a dendritic cell subset and lead to their death and the failure to mount effective TH1 responses.

  • Open Access English
    Authors: 
    Emilie Tisserant; Mathilde Malbreil; Alan Kuo; Annegret Kohler; Aikaterini Symeonidi; Raffaella Balestrini; Philippe Charron; Nina Duensing; Nicolas Frei dit Frey; Vivienne Gianinazzi-Pearson; +34 more
    Publisher: HAL CCSD
    Countries: Italy, Italy, France
    Project: EC | ECOFINDERS (264465), NSERC , ANR | ARBRE (ANR-11-LABX-0002), SNSF | Evolutionary genomics of ... (144079)

    International audience; The mutualistic symbiosis involving Glomeromycota, a distinctive phylum of early diverging Fungi, is widely hypothesized to have promoted the evolution of land plants during the middle Paleozoic. These arbuscular mycorrhizal fungi (AMF) perform vital functions in the phosphorus cycle that are fundamental to sustainable crop plant productivity. The unusual biological features of AMF have long fascinated evolutionary biologists. The coenocytic hyphae host a community of hundreds of nuclei and reproduce clonally through large multinucleated spores. It has been suggested that the AMF maintain a stable assemblage of several different genomes during the life cycle, but this genomic organization has been questioned. Here we introduce the 153-Mb haploid genome of Rhizophagus irregularis and its repertoire of 28,232 genes. The observed low level of genome polymorphism (0.43 SNP per kb) is not consistent with the occurrence of multiple, highly diverged genomes. The expansion of mating-related genes suggests the existence of cryptic sex-related processes. A comparison of gene categories confirms that R. irregularis is close to the Mucoromycotina. The AMF obligate biotrophy is not explained by genome erosion or any related loss of metabolic complexity in central metabolism, but is marked by a lack of genes encoding plant cell wall-degrading enzymes and of genes involved in toxin and thiamine synthesis. A battery of mycorrhiza-induced secreted proteins is expressed in symbiotic tissues. The present comprehensive repertoire of R. irregularis genes provides a basis for future research on symbiosis-related mechanisms in Glomeromycota.

  • Open Access English
    Authors: 
    Paolo Zanoni; Grigorios Panteloglou; Alaa Othman; Joel T. Haas; Roger Meier; Antoine Rimbert; Marta Futema; Yara Abou-Khalil; Simon F. Norrelykke; Andrzej J. Rzepiela; +36 more
    Publisher: American Heart Association
    Countries: Denmark, France, France, United Kingdom, Belgium, Netherlands
    Project: EC | ImmunoBile (694717), ANR | CHOPIN (ANR-16-RHUS-0007), EC | TRANSCARD (603091)

    Background: The LDLR (low-density lipoprotein receptor) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that regulate the activity of LDLR helps to identify pathomechanisms of hypercholesterolemia and novel therapeutic targets against atherosclerotic cardiovascular disease. Methods: We performed a genome-wide RNA interference screen for genes limiting the uptake of fluorescent LDL into Huh-7 hepatocarcinoma cells. Top hit genes were validated by in vitro experiments as well as analyses of data sets on gene expression and variants in human populations. Results: The knockdown of 54 genes significantly inhibited LDL uptake. Fifteen of them encode for components or interactors of the U2-spliceosome. Knocking down any one of 11 out of 15 genes resulted in the selective retention of intron 3 of LDLR . The translated LDLR fragment lacks 88% of the full length LDLR and is detectable neither in nontransfected cells nor in human plasma. The hepatic expression of the intron 3 retention transcript is increased in nonalcoholic fatty liver disease as well as after bariatric surgery. Its expression in blood cells correlates with LDL-cholesterol and age. Single nucleotide polymorphisms and 3 rare variants of one spliceosome gene, RBM25 , are associated with LDL-cholesterol in the population and familial hypercholesterolemia, respectively. Compared with overexpression of wild-type RBM25 , overexpression of the 3 rare RBM25 mutants in Huh-7 cells led to lower LDL uptake. Conclusions: We identified a novel mechanism of posttranscriptional regulation of LDLR activity in humans and associations of genetic variants of RBM25 with LDL-cholesterol levels.

  • Publication . Article . Preprint . 2020 . Embargo End Date: 01 Jan 2020
    Open Access
    Authors: 
    Julia V. Seidel; Monika Lendl; Vincent Bourrier; David Ehrenreich; Romain Allart; S. G. Sousa; Heather M. Cegla; Xavier Bonfils; U. Conod; A. Grandjean; +10 more
    Publisher: arXiv
    Project: ANR | GIPSE (ANR-14-CE33-0018), SNSF | Exploring exoplanets with... (140649), SNSF | Exploring exoplanets with... (184618), SNSF | Observations d'atmosphère... (186765), FCT | UID/FIS/04434/2019 (UID/FIS/04434/2019), EC | FOUR ACES (724427), SNSF | Exploring exoplanets with... (152721), FCT | UIDP/04434/2020 (UIDP/04434/2020), FCT | UIDB/04434/2020 (UIDB/04434/2020)

    WASP-127b is one of the puffiest exoplanets found to date, with a mass only $3.4$ Neptune masses, but a radius larger than Jupiter. It is also located at the border of the Neptune desert, which describes the lack of highly-irradiated Neptune-sized planets, and which remains poorly understood. Its large scale height and bright host star make the transiting WASP-127b a valuable target to characterise in transmission spectroscopy. We use combined EulerCam and TESS light curves to recalculate the system's parameters. Additionally, we present an in-depth search for sodium in four transit observations of WASP-127b, obtained as part of the Hot Exoplanet Atmosphere Resolved with Transit Spectroscopy (HEARTS) survey with the High Accuracy Radial velocity Planet Searcher (HARPS) spectrograph. Two nights from this dataset were analysed independently by another team, claiming a detection of sodium incompatible with previous studies of data from both ground and space. We show that this large sodium detection is actually due to contamination from telluric sodium emissions and the low S/N in the core of the deep stellar sodium lines. When properly accounting for these effects, the previous sodium signal is reduced to an absorption of $0.46\pm0.20\%$ ($2.3\sigma$), which is compatible with analyses of WASP-127b transits carried out with other instruments. We can fit a Gaussian to the D2 line, however, the D1 line was not detected, indicating an unusual line ratio if sodium exists in the atmosphere. Follow-up of WASP-127 at both high-resolution and with high sensitivity will be required to firmly establish the presence of sodium and analyse its line shape. Comment: 11 pages, 11 figures, published in A&A

  • Publication . Article . Other literature type . Preprint . 2022
    Open Access English
    Authors: 
    Winkler, Manuela; Plichta, Roman; Buysse, Pauline; Lohila, Annalea; Spicher, Fabien; Boeckx, Pascal; Wild, Jan; Feigenwinter, Iris; Olejnik, Janusz; Risch, Anita; +347 more
    Countries: United Kingdom, Netherlands, Spain, France, United Kingdom, Switzerland, Netherlands, Belgium, Germany, Denmark ...
    Project: EC | LEAP-AGRI (727715), EC | FORMICA (757833), EC | SustainSAHEL (861974), EC | eLTER PLUS (871128), ANR | ODYSSEE (ANR-13-ISV7-0004), FCT | UIDP/50017/2020 (UIDP/50017/2020), SNSF | ICOS-CH Phase 2 (173691), UKRI | E3 - Edinburgh Earth and ... (NE/L002558/1), ANR | IMPRINT (ANR-19-CE32-0005), NSERC ,...

    JJL received funding from the Research Foundation Flanders (grant nr. 12P1819N). The project received funding from the Research Foundation Flanders (grants nrs, G018919N, W001919N). JVDH and TWC received funding from DOB Ecology. JA received funding from the University of Helsinki, Faculty of Science (MICROCLIM, grant nr. 7510145) and Academy of Finland Flagship (grant no. 337552). PDF, CM and PV received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (ERC Starting Grant FORMICA 757833). JK received funding from the Arctic Interactions at the University of Oulu and Academy of Finland (318930, Profi 4), Maaja vesitekniikan tuki ry., Tiina and Antti Herlin Foundation, Nordenskiold Samfundet and Societas pro Fauna et Flora Fennica. MK received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). TWC received funding from National Geographic Society grant no. 9480-14 and WW-240R-17. MA received funding from CISSC (program ICRP (grant nr:2397) and INSF (grant nr: 96005914). The Royal Botanic Garden Edinburgh is supported by the Scottish Government's Rural and Environment Science and Analytical Services Division. JMA received funding from the Funding Org. Qatar Petroleum (grant nr. QUEX-CAS-QP-RD-18/19). JMA received funding from the European Union's Horizon 2020 research and innovation program (grant no. 678841) and from the Swiss National Science Foundation (grant no. 31003A_176044). JA was supported by research grants LTAUSA19137 (program INTER-EXCELLENCE, subprogram INTER-ACTION) provided by Czech Ministry of Education, Youth and Sports and 20-05840Y of the Czech Science Foundation. AA was supported by the Ministry of Science and Higher Education of the Russian Federation (grant FSRZ-2020-0014). SN, UAT, JJA, and JvO received funding from the Independent Research Fund Denmark (7027-00133B). LvdB, KT, MYB and RC acknowledge funding from the German Research Foundation within the Priority Program SPP-1803 'EarthShape: Earth Surface Shaping by Biota' (grant TI 338/14-1&2 and BA 3843/6-1). PB was supported by grant project VEGA of the Ministry of Education of the Slovak Republic and the Slovak Academy of Sciences No. 2/0132/18. Forest Research received funding from the Forestry Commission (climate change research programme). JCB acknowledges the support of Universidad Javeriana. JLBA received funding from the Direccion General de Cambio Climatico del Gobierno de Aragon; JLBA acknowledges fieldwork assistance by Ana Acin, the Ordesa y Monte Perdido National Park, and the Servicio de Medio Ambiente de Soria de la Junta de Castilla y Leon. RGB and MPB received funding from BECC - Biodiversity and Ecosystem services in a Changing Climate. MPB received funding from The European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie Grant Agreement No. 657627 and The Swedish Research Council FORMAS - future research leaders No. 2016-01187. JB received funding from the Czech Academy of Sciences (grant nr. RVO 67985939). NB received funding from the SNF (grant numbers 40FA40_154245, 20FI21_148992, 20FI20_173691, 407340_172433) and from the EU (contract no. 774124). ICOS EU research infrastructure. EU FP7 NitroEurope. EU FP7 ECLAIRE. The authors from Biological Dynamics of Forest Fragments Project, PDBFF, Instituto Nacional de Pesquisas da Amazonia, Brazil were supported by the MCTI/CNPq/FNDCT - AcAo Transversal no68/2013 - Programa de Grande Escala da Biosfera-Atmosfera na Amazonia - LBA; Project 'Como as florestas da Amazonia Central respondem as variacoes climaticas? Efeitos sobre dinamica florestal e sinergia com a fragmentacAo florestal'. This is the study 829 of the BDFFP Technical Series. to The EUCFLUX Cooperative Research Program and Forest Science and Research Institute-IPEF. NC acknowledges funding by Stelvio National Park. JC was funded by the Spanish government grant CGL2016-78093-R. ANID-FONDECYT 1181745 AND INSTITUTO ANTARTICO CHILENO (INACH FR-0418). SC received funding from the German Research Foundation (grant no. DFG- FZT 118, 202548816). The National Science Foundation, Poland (grant no. UMO-2017/27/B/ST10/02228), within the framework of the 'Carbon dioxide uptake potential of sphagnum peatlands in the context of atmospheric optical parameters and climate changes' (KUSCO2) project. SLC received funding from the South African National Research Foundation and the Australian Research Council. FM, M, KU and MU received funding from Slovak Research and Development Agency (no. APVV-19-0319). Instituto Antartico Chileno (INACH_RT-48_16), Iniciativa Cientifica Milenio Nucleo Milenio de Salmonidos Invasores INVASAL, Institute of Ecology and Biodiversity (IEB), CONICYT PIA APOYO CCTE AFB170008. PC is supported by NERC core funding to the BAS 'Biodiversity, Evolution and Adaptation Team. EJC received funding from the Norwegian Research Council (grant number 230970). GND was supported by NERC E3 doctoral training partnership grant (NE/L002558/1) at the University of Edinburgh and the Carnegie Trust for the Universities of Scotland. Monitoring stations on Livingston Island, Antarctica, were funded by different research projects of the Gobern of Spain (PERMAPLANET CTM2009-10165-E; ANTARPERMA CTM2011-15565-E; PERMASNOW CTM2014-52021-R), and the PERMATHERMAL arrangement between the University of Alcala and the Spanish Polar Committee. GN received funding from the Autonomous Province of Bolzano (ITA). The infrastructure, part of the UK Environmental Change Network, was funded historically in part by ScotNature and NERC National Capability LTS-S: UK-SCAPE; NE/R016429/1). JD was supported by the Czech Science Foundation (GA17-19376S) and MSMT (LTAUSA18007). ED received funding from the Kempe Foundation (JCK-1112 and JCK-1822). The infrastructure was supported by the Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Programme I (NPU I), grant number LO1415 and by the project for national infrastructure support CzeCOS/ICOS Reg. No. LM2015061. NE received funding from the German Research Foundation (DFG- FZT 118, 202548816). BE received funding from the GLORIA-EU project no EVK2-CT2000-00056, the Autonomous Province of Bolzano (ITA), from the Tiroler Wissenschaftsfonds and from the University of Innsbruck. RME was supported by funding to the SAFE Project from the Sime Darby Foundation. OF received funding from the German Research Foundation (DFG- FZT 118, 202548816). EFP was supported by the Jardin Botanico Atlantico (SV-20-GIJON-JBA). MF was funded by the German Federal Ministry of Education and Research (BMBF) in the context of The Future Okavango (Grant No. 01LL0912) and SASSCAL (01LG1201M; 01LG1201N) projects. EFL received funding from ANID PIA / BASAL FB210006. RAG received funding from Fondecyt 11170516, CONICYT PIA AFB170008 and ANID PIA / BASAL FB210006. MBG received funding from National Parks (DYNBIO, #1656/2015) and The Spanish Research Agency (VULBIMON, #CGL2017-90040-R). MG received funding from the Swiss National Science Foundation (ICOS-CH Phase 2 20FI20_173691). FG received funding from the German Research Foundation (DFG- FZT 118, 202548816). KG and TS received funding from the UK Biotechnology and Biological Research Council (grant = 206/D16053). SG was supported by the Research Foundation Flanders (FWO) (project G0H1517N). KJ and PH received funding from the EU Horizon2020 INFRAIA project eLTER-PLUS (871128), the project LTER-CWN (FFG, F&E Infrastrukturforderung, project number 858024) and the Austrian Climate Research Program (ACRP7 - CentForCSink - KR14AC7K11960). SH and ARB received funding through iDiv funded by the German Research Foundation (DFG- FZT 118, 202548816). LH received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). MH received funding from the Baden-Wurttemberg Ministry of Science, Research and Arts via the project DRIeR (Drought impacts, processes and resilience: making the in-visible visible). LH received funding from International Polar Year, Weston Foundation, and ArcticNet. DH received funding from Natural Sciences and Engineering Council (Canada) (RGPIN-06691). TTH received funding from Independent Research Fund Denmark (grant no. 8021-00423B) and Villum Foundation (grant no. 17523). Ministry of Education, Youth and Sports of the Czech Republic (projects LM2015078, VAN2020/01 and CZ.02.1.01/0.0/0.0/16_013/0001708). KH, CG and CJD received funding from Bolin Centre for Climate Research, Stockholm University and from the Swedish research council Formas [grant n:o 2014-00530 to KH]. JJ received funding from the Funding Org. Swedish Forest Society Foundation (grant nr. 2018-485-Steg 2 2017) and Swedish Research Council FORMAS (grant nr. 2018-00792). AJ received funding from the German Federal Ministry of Education and Research BMBF (Grant Nr. FKZ 031B0516C SUSALPS) and the Oberfrankenstiftung (Grant Nr. OFS FP00237). ISJ received funding from the Energy Research Fund (NYR-11 - 2019, NYR-18 - 2020). TJ was supported by a UK NERC Independent Research Fellowship (grant number: NE/S01537X/1). RJ received funding from National Science Centre of Poland (grant number: 2016/21/B/ST10/02271) and Polish National Centre for Research and Development (grant number: Pol-Nor/203258/31/2013). VK received funding from the Czech Academy of Sciences (grant nr. RVO 67985939). AAK received funding from MoEFCC, Govt of India (AICOPTAX project F. No. 22018/12/2015/RE/Tax). NK received funding from FORMAS (grants nr. 2018-01781, 2018-02700, 2019-00836), VR, support from the research infrastructure ICOS-SE. BK received funding from the National Research, Development and Innovation Fund of Hungary (grant nr. K128441). Ministry of Education, Youth and Sports of the Czech Republic (projects LM2015078 and CZ.02.1.01/0.0/0.0/16_013/0001708). Project B1-RNM-163-UGR-18-Programa Operativo FEDER 2018, partially funded data collection. Norwegian Research Council (NORKLIMA grants #184912 and #244525) awarded to Vigdis Vandvik. MM received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). Project CONICYT-PAI 79170119 and ANID-MPG 190029 awarded to Roy Mackenzie. This work was partly funded by project MIUR PON Cluster OT4CLIMA. RM received funding from the SNF project number 407340_172433. FM received funding from the Stelvio National Park. PM received funding from AIAS-COFUND fellowship programme supported by the Marie Skodowska- Curie actions under the European Union's Seventh Framework Pro-gramme for Research, Technological development and Demonstration (grant agreement no 609033) and the Aarhus University Research Foundation, Denmark. RM received funding from the Ministry of Education, Youth and Sports of the Czech Republic (project LTT17033). SM and VM received funding from EU FP6 NitroEurope (grant nr. 17841), EU FP7 ECLAIRE (grant nr. 282910), the Ministry of Education and Science of Ukraine (projects nr. 505, 550, 574, 602), GEF-UNEP funded "Toward INMS" project (grant nr. NEC05348) and ENI CBC BSB PONTOS (grant nr. BSB 889). The authors from Biological Dynamics of Forest Fragments Project, PDBFF, Instituto Nacional de Pesquisas da Amazonia, Brazil were supported by the MCTI/CNPq/FNDCT - AcAo Transversal no68/2013 - Programa de Grande Escala da Biosfera-Atmosfera na Amazonia - LBA; Project 'Como as florestas da Amazonia Central respondem as variacoes climaticas? Efeitos sobre dinamica florestal e sinergia com a fragmentacAo florestal'. FJRM was financially supported by the Netherlands Organization for Scientific Research (VICI grant 016.VICI.170.072) and Research Foundation Flanders (FWO-SBO grant S000619N). STM received funding from New Frontiers in Research Fund-Exploration (grant nr. NFRF-2018-02043) and NSERC Discovery. MMR received funding from the Australian Research Council Discovery Early Career Research Award (grant nr. DE180100570). JAM received funding from the National Science Foundation (DEB 1557094), International Center for Advanced Renewable Energy and Sustainability (I-CARES) at Washington University in St. Louis, ForestGEO, and Tyson Research Center. IM-S was funded by the UK Natural Environment Research Council through the ShrubTundra Project (NE/M016323/1). MBN received funding from FORMAS, VR, Kempe Foundations support from the research infrastructures ICOS and SITES. MDN received funding from CONICET (grant nr. PIP 112-201501-00609). Spanish Ministry of Science grant PID2019-110521GB-I00 and Catalan government grant 2017-1005. French National Research Agency (ANR) in the frame of the Cluster of Excellence COTE (project HydroBeech, ANR-10-LABX-45). VLIR-OUS, under the Institutional University Coorperation programme (IUC) with Mountains of the Moon University. Project LAS III 77/2017/B entitled: \"Estimation of net carbon dioxide fluxes exchanged between the forest ecosystem on post-agricultural land and between the tornado-damaged forest area and the atmosphere using spectroscopic and numerical methods\", source of funding: General Directorate of State Forests, Warsaw, Poland. Max Planck Society (Germany), RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science, project number 20-45-242908. Estonian Research Council (PRG609), and the European Regional Development Fund (Centre of Excellence EcolChange). Canada-Denmark Arctic Research Station Early Career Scientist Exchange Program, from Polar knowledge Canada (POLAR) and the Danish Agency for Science and Higher Education. AP received funding from Fondecyt 1180205, CONICYT PIA AFB170008 and ANID PIA / BASAL FB210006. MP received funding from the Funding Org. Knut and Alice Wallenberg Foundation (grant nr. 2015.0047), and acknowledges funding from the Swedish Research Council (VR) with contributing research institutes to both the SITES and ICOS Sweden infrastructures. JP and RO were funded by the Spanish Ministry of Science grant PID2019-110521GB-I00, the fundacion Ramon Areces grant ELEMENTAL-CLIMATE, and the Catalan government grant 2017-1005. MPB received funding from the Svalbard Environmental Protection Fund (grant project number 15/128) and the Research Council of Norway (Arctic Field Grant, project number 269957). RP received funding from the Ministry of Education, Youth and Sports of the Czech Republic (grant INTER-TRANSFER nr. LTT20017). LTSER Zone Atelier Alpes; Federation FREE-Alpes. RP received funding from a Humboldt Fellowship for Experienced Researchers. Prokushkin AS and Zyryanov VI contribution has been supported by the RFBR grant #18-05-60203-Arktika. RPu received founding from the Polish National Science Centre (grant project number 2017/27/B/NZ8/00316). ODYSSEE project (ANR-13-ISV7-0004, PN-II-ID-JRP-RO-FR-2012). KR was supported through an Australian Government Research Training Program Scholarship. Fieldwork was supported by the Global Challenges program at the University of Wollongong, the ARC the Australian Antarctic Division and INACH. DR was funded by the project SUBANTECO IPEV 136 (French Polar Institute Paul-Emile Victor), Zone Atelier CNRS Antarctique et Terres Australes, SAD Region Bretagne (Project INFLICT), BiodivERsa 2019-2020 BioDivClim call 'ASICS' (ANR-20-EBI5-0004). SAR received funding from the Australian Research Council. NSF grant #1556772 to the University of Notre Dame. Pavia University (Italy). OR received funding from EU-LEAP-Agri (RAMSES II), EU-DESIRA (CASSECS), EU-H2020 (SustainSahel), AGROPOLIS and TOTAL Foundations (DSCATT), CGIAR (GLDC). AR was supported by the Russian Science Foundation (Grant 18-74-10048). Parc national des Ecrins. JS received funding from Vetenskapsradet grant nr (No: 2014-04270), ALTER-net multi-site grant, River LIFE project (LIFE08 NAT/S/000266), Flexpeil. Helmholtz Association long-term research program TERENO (Terrestrial Environmental Observatories). PS received funding from the Polish Ministry of Science and Higher Education (grant nr. N N305 304840). AS acknowledges funding by ETH Zurich project FEVER ETH-27 19-1. LSC received funding from NSERC Canada Graduate Scholarship (Doctoral) Program; LSC was also supported by ArcticNet-NCE (insert grant #). Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (141513/2017-9); FundacAo Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (E26/200.84/2019). ZS received funding from the SRDA (grants nos. APVV-16-0325 and APVV-20-0365) and from the ERDF (grant no. ITMS 313011S735, CE LignoSilva). JS, MB and CA received funding from core budget of ETH Zurich. State excellence Program M-V \"WETSCAPES\". AfricanBioServices project funded by the EU Horizon 2020 grant number 641918. The authors from KIT/IMK-IFU acknowledge the funding received within the German Terrestrial Environmental Observatories (TERENO) research program of the Helmholtz Association and from the Bavarian Ministry of the Environment and Public Health (UGV06080204000). Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), project number 192626868, in the framework of the collaborative German-Indonesian research project CRC 990 (SFB): 'EFForTS, Ecological and Socioeconomic Functions of Tropical Lowland Rainforest Transformation Systems (Sumatra, Indonesia)'. MS received funding from the Ministry of Education, Youth and Sports of the Czech Republic (grant nr. INTER-TRANSFER LTT19018). TT received funding from the Swedish National Space Board (SNSB Dnr 95/16) and the CASSECS project supported by the European Union. HJDT received funding from the UK Natural Environment Research Council (NERC doctoral training partnership grant NE/L002558/1). German Science Foundation (DFG) GraKo 2010 \"Response\". PDT received funding from the MEMOIRE project (PN-III-P1-1.1-PD2016-0925). Arctic Challenge for Sustainability II (ArCS II; JPMXD1420318865). JU received funding from Czech Science Foundation (grant nr. 21-11487S). TU received funding from the Romanian Ministry of Education and Research (CCCDI - UEFISCDI -project PN-III-P2-2.1-PED-2019-4924 and PN2019-2022/19270201-Ctr. 25N BIODIVERS 3-BIOSERV). AV acknowledge funding from RSF, project 21-14-00209. GFV received funding from the Dutch Research Council NWO (Veni grant, no. 863.14.013). Australian Research Council Discovery Early Career Research Award DE140101611. FGAV received funding from the Portuguese Science Foundation (FCT) under CEECIND/02509/2018, CESAM (UIDP/50017/2020+UIDB/50017/2020), FCT/MCTES through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020. Ordesa y Monte Perdido National Park. MVI received funding from the Spanish Ministry of Science and Innovation through a doctoral grant (FPU17/05869). JW received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). CR and SW received funding from the Swiss Federal Office for the Environment (FOEN) and the de Giacomi foundation. YY received funding from the National Natural Science Foundation of China (Grant no. 41861134039 and 41941015). ZY received funding from the National Natural Science Foundation of China (grant nr. 41877458). FZ received funding from the Swiss National Science Foundation (grant nr. 172198 and 193645). PZ received funding from the Funding Org. Knut and Alice Wallenberg Foundation (grant no. 2015.0047). JL received funding from (i) the Agence Nationale de la Recherche (ANR), under the framework of the young investigators (JCJC) funding instrument (ANR JCJC Grant project NoANR-19-CE32-0005-01: IMPRINT) (ii) the Centre National de la Recherche Scientifique (CNRS) (Defi INFINITI 2018: MORFO); and the Structure Federative de Recherche (SFR) Condorcet (FR CNRS 3417: CREUSE). Fieldwork in the Arctic got facilitated by funding from the EU INTERACT program. SN, UAT, JJA and JvO would like to thank the field team of the Vegetation Dynamics group for their efforts and hard work. We acknowledge Dominique Tristan for letting access to the field. For the logistic support the crew of INACH and Gabriel de Castilla Station team on Deception Island. We thank the Inuvialuit and Kluane First Nations for the opportunity to work on their land. MAdP acknowledges fieldwork assistance and logistics support to Unidad de Tecnologia Marina CSIC, and the crew of Juan Carlos I and Gabriel de Castilla Spanish Antarctic Stations, as well as to the different colleagues from UAH that helped on the instrument maintenance. ERF acknowledges fieldwork assistance by Martin Heggli. MBG acknowledges fieldwork and technical assistance by P Abadia, C Benede, P Bravo, J Gomez, M Grasa, R Jimenez, H Miranda, B Ponz, J Revilla and P Tejero and the Ordesa and Monte Perdido National Park staff. LH acknowledges field assistance by John Jacobs, Andrew Trant, Robert Way, Darroch Whitaker; we acknowledge the Inuit of Nunatsiavut, and the Co-management Board of Torngat Mountains National Park for their support of this project and acknowledge that the field research was conducted on their traditional lands. We thank our many bear guides, especially Boonie, Eli, Herman, John and Maria Merkuratsuk. AAK acknowledges field support of Akhtar Malik, Rameez Ahmad. Part of microclimatic records from Saxony was funded by the Saxon Switzerland National Park Administration. Tyson Research Center. JP acknowledges field support of Emmanuel Malet (Edytem) and Rangers of Reserves Naturelles de Haute-Savoie (ASTERS). Practical help: Roel H. Janssen, N. Huig, E. Bakker, Schools in the tepaseforsoket, Forskar fredag, Erik Herberg. The support by the Bavarian Forest National Park administration is highly appreciated. LvdB acknowledges CONAF and onsite support from the park rangers from PN Pan de Azucar, PN La Campana, PN Nahuelbuta and from communidad agricola Quebrada de Talca. JL and FS acknowledge Manuel Nicolas and all forest officers from the Office National des Forets (ONF) who are in charge of the RENECOFOR network and who provided help and local support for the installation and maintenance of temperature loggers in the field. Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1-km2 resolution for 0–5 and 5–15 cm soil depth. These maps were created by calculating the difference (i.e. offset) between in situ soil temperature measurements, based on time series from over 1200 1-km2 p ixels ( summarized f rom 8 519 u nique t emperature sensors) across all the world's major terrestrial biomes, and coarse-grained air temperature estimates from ERA5-Land (an atmospheric reanalysis by the European Centre for Medium-Range Weather Forecasts). We show that mean annual soil temperature differs markedly from the corresponding gridded air temperature, by up to 10°C (mean = 3.0 ± 2.1°C), with substantial variation across biomes and seasons. Over the year, soils in cold and/or dry biomes are substantially warmer (+3.6 ± 2.3°C) than gridded air temperature, whereas soils in warm and humid environments are on average slightly cooler (−0.7 ± 2.3°C). The observed substantial and biome-specific offsets emphasize that the projected impacts of climate and climate change on near-surface biodiversity and ecosystem functioning are inaccurately assessed when air rather than soil temperature is used, especially in cold environments. The global soil-related bioclimatic variables provided here are an important step forward for any application in ecology and related disciplines. Nevertheless, we highlight the need to fill remaining geographic gaps by collecting more in situ measurements of microclimate conditions to further enhance the spatiotemporal resolution of global soil temperature products for ecological applications. AIAS-COFUND fellowship programme - Marie Skodowska- Curie actions under the European Union's Seventh Framework Pro-gramme for Research, Technological development and Demonstration 609033 European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie Grant 657627 SNF 407340_172433 40FA40_154245 20FI21_148992 20FI20_173691 Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (UEFISCDI) PN-III-P2-2.1-PED-2019-4924 PN2019-2022/19270201 Project 'Como as florestas da Amazonia Central respondem as variacoes climaticas? Efeitos sobre dinamica florestal e sinergia com a fragmentacAo florestal' Ministry of Education, Youth & Sports - Czech Republic LM2015078 VAN2020/01 CZ.02.1.01/0.0/0.0/16_013/0001708 LTT17033 LTT20017 INTER-TRANSFER LTT19018 Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Programme I (NPU I) LO1415 International Center for Advanced Renewable Energy and Sustainability (I-CARES) at Washington University in St. Louis Bavarian Ministry of the Environment and Public Health UGV06080204000 German Research Foundation (DFG) 192626868 French National Research Agency (ANR) ANR-19-CE32-0005-01 Centre National de la Recherche Scientifique (CNRS) Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) PIA APOYO CCTE AFB170008 PIA AFB170008 grant project VEGA of the Ministry of Education of the Slovak Republic Slovak Academy of Sciences 2/0132/18 Portuguese Foundation for Science and Technology CEECIND/02509/2018 CESAM UIDP/50017/2020+UIDB/50017/2020 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 11170516 1180205 Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) E26/200.84/2019 German Terrestrial Environmental Observatories (TERENO) research program of the Helmholtz Association Kempe Foundations - research infrastructure ICOS Kempe Foundations - research infrastructure SITES Gobern of Spain PERMAPLANET CTM2009-10165-E ANTARPERMA CTM2011-15565-E PERMASNOW CTM2014-52021-R project for national infrastructure support CzeCOS/ICOS LM2015061 GLORIA-EU EVK2-CT2000-00056 German Research Foundation (DFG) DFG- FZT 118 202548816 TI 338/14-1 TI 338/14-2 BA 3843/6-1 Swedish Research Council Swedish Research Council Formas 2014-00530 2018-00792 2016-01187 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) PIP 112-201501-00609 NERC E3 doctoral training partnership grant at the University of Edinburgh NE/L002558/1 Biotechnology and Biological Sciences Research Council (BBSRC) 206/D16053 FWO G0H1517N UK Natural Environment Research Council through the ShrubTundra Project NE/M016323/1 Scottish Government's Rural and Environment Science and Analytical Services Division Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 141513/2017-9 National Natural Science Foundation of China (NSFC) 41861134039 41941015 41877458 Ministry of Science and Higher Education of the Russian Federation FSRZ-2020-0014 Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-06691 Grant Agency of the Czech Republic 20-28119S 20-05840Y GA17-19376S 21-11487S Federal Ministry of Education & Research (BMBF) 01LL0912 01LG1201M 01LG1201N Polish National Centre for Research and Development Pol-Nor/203258/31/2013 Structure Federative de Recherche (SFR) Condorcet (FR CNRS 3417: CREUSE) Krasnoyarsk Territory Krasnoyarsk Regional Fund of Science 20-45-242908 Netherlands Organization for Scientific Research (NWO) 016.VICI.170.072 Austrian Climate Research Program ACRP7 - CentForCSink - KR14AC7K11960 National Research, Development and Innovation Fund of Hungary K128441 Federal Ministry of Education & Research (BMBF) FKZ 031B0516C SUSALPS project SUBANTECO IPEV 136 (French Polar Institute Paul-Emile Victor) EU-LEAP-Agri (RAMSES II) EU-DESIRA (CASSECS) EU-H2020 (SustainSahel) Portuguese Foundation for Science and Technology European Commission European Union's Horizon 2020 research and innovation program 678841 Natural Sciences and Engineering Research Council of Canada (NSERC) Ministry of Education, Youth & Sports - Czech Republic LTAUSA18007 Ministry of Education, Youth & Sports - Czech Republic LTAUSA19137 ALTER-net multi-site grant, River LIFE project LIFE08 NAT/S/000266 Netherlands Organization for Scientific Research (NWO) 863.14.013 Russian Foundation for Basic Research (RFBR) 18-05-60203-Arktika Arctic Challenge for Sustainability II (ArCS II) JPMXD1420318865 BECC - Biodiversity and Ecosystem services in a Changing Climate Swedish Research Council Formas 2018-01781 2018-02700 2019-00836 Smithsonian Institution Smithsonian Tropical Research Institute Ministry of Science and Higher Education, Poland N N305 304840 University of Helsinki, Faculty of Science (MICROCLIM) 7510145 BiodivERsa 2019-2020 BioDivClim call 'ASICS' ANR-20-EBI5-0004 iDiv by the German Research Foundation DFG- FZT 118 202548816 MoEFCC, Govt of India (AICOPTAX project) 22018/12/2015/RE/Tax Direccion General de Cambio Climatico del Gobierno de Aragon National Science Foundation, Poland UMO-2017/27/B/ST10/02228 Ministry of Education and Science of Ukraine 505 550 574 602 Norwegian Research Council (NORKLIMA grants) 184912 244525 New Frontiers in Research Fund-Exploration NFRF-2018-02043 ODYSSEE project (PN-II-ID-JRP-RO-FR-2012) ANR-13-ISV7-0004 Independent Research Fund Denmark 8021-00423B 7027-00133B Global Challenges program at the University of Wollongong project LTER-CWN (FFG, F&E Infrastrukturforderung) 858024 Instituto Antartico Chileno INACH_RT-48_16 INACH FR-0418 Baden-Wurttemberg Ministry of Science, Research and Arts Swedish Research Council Formas Swedish Research Council Natural Environment Research Council (NERC) NE/L002558/1 Bolin Centre for Climate Research, Stockholm University Swedish Forest Society Foundation 2018-485-Steg 2 2017 Swiss National Science Foundation (SNSF) 20FI20_173691 Co-management Board of Torngat Mountains National Park NERC National Capability LTS-S: UK-SCAPE NE/R016429/1 UK NERC Independent Research Fellowship NE/S01537X/1 General Directorate of State Forests, Warsaw, Poland French National Research Agency (ANR) ANR-10-LABX-45 National Science Centre, Poland 2016/21/B/ST10/02271 NSERC Canada Graduate Scholarship (Doctoral) Program Consiliul National al Cercetarii Stiintifice (CNCS) Slovak Research and Development Agency APVV-19-0319 Spanish Research Agency (VULBIMON) CGL2017-90040-R Polish National Science Centre 2017/27/B/NZ8/00316 Zone Atelier CNRS Antarctique et Terres Australes Energy Research Fund NYR-11 - 2019 NYR-18 - 2020 EU Horizon2020 INFRAIA project eLTER-PLUS 871128 Iran National Science Foundation (INSF) 96005914 Carnegie Trust for the Universities of Scotland Programa Operativo FEDER 2018 B1-RNM-163-UGR-18 Research Foundation Flanders (FWO-SBO) S000619N Humboldt Fellowship for Experienced Researchers Swiss Federal Office for the Environment (FOEN) European Commission 172198 193645 31003A_176044 European Research Council (ERC) FORMICA 757833 Department of Industry, Innovation and Science fundacion Ramon Areces grant ELEMENTAL-CLIMATE FEDER, within the PT2020 Partnership Agreement Aarhus University Research Foundation, Denmark National Geographic Society 9480-14 WW-240R-17 Saxon Switzerland National Park Administration National Science Foundation (NSF) DEB 1557094 Arctic Interactions at the University of Oulu Russian Science Foundation (RSF) 21-14-00209. Svalbard Environmental Protection Fund 15/128 Russian Science Foundation (RSF) 18-74-10048 Knut & Alice Wallenberg Foundation 2015.0047 Bavarian Forest National Park administration Russian Foundation for Basic Research (RFBR) National Research Foundation - South Africa Natural Environment Research Council (NERC) National Science Foundation (NSF) 1556772 MEMOIRE project PN-III-P1-1.1-PD2016-0925 Jardin Botanico Atlantico SV-20-GIJON-JBA Swedish National Space Board (SNSB) 95/16 Swiss National Science Foundation (SNSF) Spanish Government PID2019-110521GB-I00 Australian Research Council DE180100570 Australian Research Council DE140101611 Czech Academy of Sciences RVO 67985939 SAD Region Bretagne (Project INFLICT) CASSECS project by the European Union ARC the Australian Antarctic Division Autonomous Province of Bolzano (ITA) Qatar Petroleum QUEX-CAS-QP-RD-18/19 ERDF (CE LignoSilva) ITMS 313011S735 European Commission CGL2016-78093-R Societas pro Fauna et Flora Fennica Swedish Research Council 2014-04270 Kempe Foundation JCK-1112 JCK-1822 project MIUR PON Cluster OT4CLIMA Research Council of Norway 269957 Tiina and Antti Herlin Foundation National Parks (DYNBIO) 1656/2015 Academy of Finland 318930 337552 European Commission 17841 774124 Estonian Research Council PRG609 research infrastructure ICOS-SE UK Research & Innovation (UKRI) Oberfrankenstiftung OFS FP00237 SRDA APVV-16-0325 APVV-20-0365 Spanish Government FPU17/05869 FWO G018919N W001919N 12P1819N Maaja vesitekniikan tuki ry. Catalan government 2017-1005 ETH Zurich FEVER ETH-27 19-1 Australian Research Council Tiroler Wissenschaftsfonds Research Council of Norway ENI CBC BSB PONTOS BSB 889 European Commission 230970 CISSC (program ICRP) 2397 ANID PIA / BASAL FB210006 EU FP6 NitroEurope 17841 Swedish Research Council University of Innsbruck Villum Foundation 17523 MCTI/CNPq/FNDCT 68/2013 25N BIODIVERS 3-BIOSERV Spanish Polar Committee Nordenskiold Samfundet EU Horizon 2020 641918 EU FP7 ECLAIRE 282910 Tyson Research Center Stelvio National Park Universidad Javeriana Australian Government ANID-FONDECYT 1181745 Sime Darby Foundation Inuit of Nunatsiavut CONICYT-PAI 79170119 University of Alcala EU INTERACT program Forestry Commission Spanish Government Giacomi foundation Max Planck Society GEF-UNEP NEC05348 Weston Foundation ANID-MPG 190029 ArcticNet-NCE Compete 2020 DOB Ecology ScotNature ETH Zurich ArcticNet AGROPOLIS Flexpeil Total SA CGIAR INACH

  • Open Access
    Authors: 
    Andreea Manole; Stephanie Efthymiou; Emer O'Connor; Marisa I. Mendes; Matthew J. Jennings; Reza Maroofian; Indran Davagnanam; Kshitij Mankad; Maria Rodriguez Lopez; Vincenzo Salpietro; +82 more
    Publisher: Elsevier BV
    Countries: Netherlands, France, Turkey
    Project: WT | Strengthening the neuromu... (201064), EC | HUCNC (249968), WT | Exploring novel molecular... (109915), UKRI | MRC Centre for Neuromuscu... (G0601943), ANR | UNISTRA (ANR-10-IDEX-0002), EC | REVERSIBLECOX (309548)

    Aminoacyl-tRNA synthetases (ARSs) are ubiquitous, ancient enzymes that charge amino acids to cognate tRNA molecules, the essential first step of protein translation. Here, we describe 32 individuals from 21 families, presenting with microcephaly, neurodevelopmental delay, seizures, peripheral neuropathy, and ataxia, with de novo heterozygous and bi-allelic mutations in asparaginyl-tRNA synthetase (NARS1). We demonstrate a reduction in NARS1 mRNA expression as well as in NARS1 enzyme levels and activity in both individual fibroblasts and induced neural progenitor cells (iNPCs). Molecular modeling of the recessive c.1633C>T (p.Arg545Cys) variant shows weaker spatial positioning and tRNA selectivity. We conclude that de novo and bi-allelic mutations in NARS1 are a significant cause of neurodevelopmental disease, where the mechanism for de novo variants could be toxic gain-of-function and for recessive variants, partial loss-of-function.

  • Publication . Other literature type . Article . 2018
    Open Access English
    Authors: 
    Alessandro Genoni; Lukáš Bučinský; Nicolas Claiser; Julia Contreras-García; Birger Dittrich; Paulina M. Dominiak; Enrique Espinosa; Carlo Gatti; Paolo Giannozzi; Jean-Michel Gillet; +12 more
    Publisher: Wiley-VCH Verlag
    Countries: France, Sweden, Italy, Italy
    Project: SNSF | Physical and chemical pro... (160157), ARC | Interatomic bonding in al... (FT110100427), NSERC , ANR | HalX-Bond (ANR-08-BLAN-0091), ANR | QuMacroRef (ANR-17-CE29-0005), EC | MaX (676598)

    International audience; Crystallography and quantum mechanics have always been tightly connected because reliable quantum mechanical models are needed to determine crystal structures. Due to this natural synergy, nowadays accurate distributions of electrons in space can be obtained from diffraction and scattering experiments. In the original definition of quantum crystallography (QCr) given by Massa, Karle and Huang, direct extraction of wavefunctions or density matrices from measured intensities of reflections or, conversely, ad hoc quantum mechanical calculations to enhance the accuracy of the crystallographic refinement are implicated. Nevertheless, many other active and emerging research areas involving quantum mechanics and scattering experiments are not covered by the original definition although they enable to observe and explain quantum phenomena as accurately and successfully as the original strategies. Therefore, we give an overview over current research that is related to a broader notion of QCr, and discuss options how QCr can evolve to become a complete and independent domain of natural sciences. The goal of this paper is to initiate discussions around QCr, but not to find a final definition of the field.

  • Open Access English
    Authors: 
    Leonid L. Rubchinsky; Sungwoo Ahn; Wouter Klijn; Ben Cumming; Stuart Yates; Vasileios Karakasis; Alexander Peyser; Marmaduke Woodman; Sandra Diaz-Pier; James Deraeve; +193 more
    Countries: France, Italy
    Project: UKRI | A scalable chip multiproc... (EP/D07908X/1), NSF | Cellular mechanisms of th... (0750456), NIH | From Cells to Systems and... (5R90DA033462-03), EC | SpikeControl (658479), CIHR , WT , ANR | PSL (ANR-10-IDEX-0001), UKRI | Biologically-Inspired Mas... (EP/G015740/1), EC | INDIREA (606901), EC | M4 (323711),...

    International audience; No abstract available

  • Open Access English
    Authors: 
    Anke Arentsen; Else Starkenburg; Nicolas F. Martin; Vanessa Hill; Rodrigo A. Ibata; Andrea Kunder; Mathias Schultheis; K. A. Venn; Daniel B. Zucker; David Aguado; +13 more
    Publisher: HAL CCSD
    Countries: Italy, Canada, Switzerland, France
    Project: NSF | Pan-STARRS1: Operations; ... (1238877), ANR | Pristine (ANR-18-CE31-0017), ARC | Discovery Projects - Gran... (DP180101791), SNSF | Globular clusters or dwar... (168065), EC | OPTICON (730890)

    Our Galaxy is known to contain a central boxy/peanut-shaped bulge, yet the importance of a classical, pressure-supported component within the central part of the Milky Way is still being debated. It should be most visible at low metallicity, a regime that has not yet been studied in detail. Using metallicity-sensitive narrow-band photometry, the Pristine Inner Galaxy Survey (PIGS) has collected a large sample of metal-poor ([Fe/H] < -1.0) stars in the inner Galaxy to address this open question. We use PIGS to trace the metal-poor inner Galaxy kinematics as function of metallicity for the first time. We find that the rotational signal decreases with decreasing [Fe/H], until it becomes negligible for the most metal-poor stars. Additionally, the velocity dispersion increases with decreasing metallicity for -3.0 < [Fe/H] < -0.5, with a gradient of -44 $\pm$ 4 km$\,$s$^{-1}\,$dex$^{-1}$. These observations may signal a transition between Galactic components of different metallicities and kinematics, a different mapping onto the boxy/peanut-shaped bulge for former disk stars of different metallicities and/or the secular dynamical and gravitational influence of the bar on the pressure-supported component. Our results provide strong constraints on models that attempt to explain the properties of the inner Galaxy. 5 pages + appendices, accepted to MNRAS Letters

  • Open Access
    Authors: 
    R. Akutsu; C. Alt; S. Ban; Gareth J. Barker; G.D. Barr; C. Barry; A. Beloshapkin; F. Bench; Vincenzo Berardi; S. Berkman; +181 more
    Publisher: American Physical Society (APS)
    Project: NSERC , EC | SK2HK (872549), EC | JENNIFER2 (822070), EC | INPhINIT (713673), ANR | SUNCORE (ANR-19-CE31-0001), EC | FELLINI (754496)

    We thank the J-PARC staff for superb accelerator performance. We thank the CERN NA61/SHINE Collaboration for providing valuable particle production data. We acknowledge the support of MEXT, Japan; NSERC (Grant No. SAPPJ-2014-00031), the NRC and CFI, Canada; the CEA and CNRS/IN2P3, France; the DFG, Germany; the INFN, Italy; the National Science Centre and Ministry of Science and Higher Education, Poland; the RSF (Grant No. 19-12-00325) and the Ministry of Science and Higher Education, Russia; MINECO and ERDF funds, Spain; the SNSF and SERI, Switzerland; the STFC, UK; and the DOE, USA. We also thank CERN for the UA1/NOMAD magnet, DESY for the HERA-B magnet mover system, NII for SINET4, the WestGrid and SciNet consortia in Compute Canada, and GridPP in the United Kingdom. In addition, participation of individual researchers and institutions has been further supported by funds from the ERC (FP7), “la Caixa” Foundation (ID 100010434, fellowship code LCF/BQ/IN17/11620050), the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska- Curie Grants Agreement No. 713673 and No. 754496, and H2020 Grant No. RISE-GA822070-JENNIFER2 2020 and No. RISE-GA872549-SK2HK; the JSPS, Japan; the Royal Society, UK; French ANR Grant No. ANR-19- CE31-0001; and the DOE Early Career programme, USA.

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  • Open Access English
    Authors: 
    Xiao-Fei Kong; Rubén Martínez-Barricarte; J. Kennedy; Federico Mele; Tomi Lazarov; Elissa K. Deenick; Cindy S. Ma; Gaëlle Breton; Kimberly Lucero; David Langlais; +31 more
    Project: EC | PREDICT (323183), NIH | A genetic dissection of M... (5R01AI089970-02), NIH | Nramp1 in macrophage defe... (5R01AI035237-12), NIH | Transforming Translationa... (3UL1TR000043-07S1), NIH | Genome-Wide Dissection of... (5R37AI095983-07), NIH | Clinical Core (1U19AI118626-01), SNSF | Studies on T cell activat... (170213), ANR | GENMSMD (ANR-16-CE17-0005), ANR | IFNGPHOX (ANR-13-ISV3-0001)

    Human inborn errors of IFN-γ immunity underlie mycobacterial diseases. We describe patients with Mycobacterium bovis (BCG) disease who are homozygous for loss-of-function mutations of SPPL2A. This gene encodes a transmembrane protease that degrades the N-terminal fragment (NTF) of CD74 (HLA invariant chain) in antigen-presenting cells. The CD74 NTF therefore accumulates in the HLA class II+ myeloid and lymphoid cells of SPPL2a-deficient patients. This toxic fragment selectively depletes IL-12- and IL-23-producing CD1c+ conventional dendritic cells (cDC2s) and their circulating progenitors. Moreover, SPPL2a-deficient memory TH1* cells selectively fail to produce IFN-γ when stimulated with mycobacterial antigens in vitro. Finally, Sppl2a–/– mice lack cDC2s, have CD4+ T cells that produce small amounts of IFN-γ after BCG infection, and are highly susceptible to infection with BCG or Mycobacterium tuberculosis. These findings suggest that inherited SPPL2a deficiency in humans underlies mycobacterial disease by decreasing the numbers of cDC2s and impairing IFN-γ production by mycobacterium-specific memory TH1* cells. Primary immunodeficiency can predispose patients to mycobacterial disease. Casanova and colleagues identify novel human mutations in the enzyme SPPL2A that result in selective accumulation of CD74 in a dendritic cell subset and lead to their death and the failure to mount effective TH1 responses.

  • Open Access English
    Authors: 
    Emilie Tisserant; Mathilde Malbreil; Alan Kuo; Annegret Kohler; Aikaterini Symeonidi; Raffaella Balestrini; Philippe Charron; Nina Duensing; Nicolas Frei dit Frey; Vivienne Gianinazzi-Pearson; +34 more
    Publisher: HAL CCSD
    Countries: Italy, Italy, France
    Project: EC | ECOFINDERS (264465), NSERC , ANR | ARBRE (ANR-11-LABX-0002), SNSF | Evolutionary genomics of ... (144079)

    International audience; The mutualistic symbiosis involving Glomeromycota, a distinctive phylum of early diverging Fungi, is widely hypothesized to have promoted the evolution of land plants during the middle Paleozoic. These arbuscular mycorrhizal fungi (AMF) perform vital functions in the phosphorus cycle that are fundamental to sustainable crop plant productivity. The unusual biological features of AMF have long fascinated evolutionary biologists. The coenocytic hyphae host a community of hundreds of nuclei and reproduce clonally through large multinucleated spores. It has been suggested that the AMF maintain a stable assemblage of several different genomes during the life cycle, but this genomic organization has been questioned. Here we introduce the 153-Mb haploid genome of Rhizophagus irregularis and its repertoire of 28,232 genes. The observed low level of genome polymorphism (0.43 SNP per kb) is not consistent with the occurrence of multiple, highly diverged genomes. The expansion of mating-related genes suggests the existence of cryptic sex-related processes. A comparison of gene categories confirms that R. irregularis is close to the Mucoromycotina. The AMF obligate biotrophy is not explained by genome erosion or any related loss of metabolic complexity in central metabolism, but is marked by a lack of genes encoding plant cell wall-degrading enzymes and of genes involved in toxin and thiamine synthesis. A battery of mycorrhiza-induced secreted proteins is expressed in symbiotic tissues. The present comprehensive repertoire of R. irregularis genes provides a basis for future research on symbiosis-related mechanisms in Glomeromycota.

  • Open Access English
    Authors: 
    Paolo Zanoni; Grigorios Panteloglou; Alaa Othman; Joel T. Haas; Roger Meier; Antoine Rimbert; Marta Futema; Yara Abou-Khalil; Simon F. Norrelykke; Andrzej J. Rzepiela; +36 more
    Publisher: American Heart Association
    Countries: Denmark, France, France, United Kingdom, Belgium, Netherlands
    Project: EC | ImmunoBile (694717), ANR | CHOPIN (ANR-16-RHUS-0007), EC | TRANSCARD (603091)

    Background: The LDLR (low-density lipoprotein receptor) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that regulate the activity of LDLR helps to identify pathomechanisms of hypercholesterolemia and novel therapeutic targets against atherosclerotic cardiovascular disease. Methods: We performed a genome-wide RNA interference screen for genes limiting the uptake of fluorescent LDL into Huh-7 hepatocarcinoma cells. Top hit genes were validated by in vitro experiments as well as analyses of data sets on gene expression and variants in human populations. Results: The knockdown of 54 genes significantly inhibited LDL uptake. Fifteen of them encode for components or interactors of the U2-spliceosome. Knocking down any one of 11 out of 15 genes resulted in the selective retention of intron 3 of LDLR . The translated LDLR fragment lacks 88% of the full length LDLR and is detectable neither in nontransfected cells nor in human plasma. The hepatic expression of the intron 3 retention transcript is increased in nonalcoholic fatty liver disease as well as after bariatric surgery. Its expression in blood cells correlates with LDL-cholesterol and age. Single nucleotide polymorphisms and 3 rare variants of one spliceosome gene, RBM25 , are associated with LDL-cholesterol in the population and familial hypercholesterolemia, respectively. Compared with overexpression of wild-type RBM25 , overexpression of the 3 rare RBM25 mutants in Huh-7 cells led to lower LDL uptake. Conclusions: We identified a novel mechanism of posttranscriptional regulation of LDLR activity in humans and associations of genetic variants of RBM25 with LDL-cholesterol levels.

  • Publication . Article . Preprint . 2020 . Embargo End Date: 01 Jan 2020
    Open Access
    Authors: 
    Julia V. Seidel; Monika Lendl; Vincent Bourrier; David Ehrenreich; Romain Allart; S. G. Sousa; Heather M. Cegla; Xavier Bonfils; U. Conod; A. Grandjean; +10 more
    Publisher: arXiv
    Project: ANR | GIPSE (ANR-14-CE33-0018), SNSF | Exploring exoplanets with... (140649), SNSF | Exploring exoplanets with... (184618), SNSF | Observations d'atmosphère... (186765), FCT | UID/FIS/04434/2019 (UID/FIS/04434/2019), EC | FOUR ACES (724427), SNSF | Exploring exoplanets with... (152721), FCT | UIDP/04434/2020 (UIDP/04434/2020), FCT | UIDB/04434/2020 (UIDB/04434/2020)

    WASP-127b is one of the puffiest exoplanets found to date, with a mass only $3.4$ Neptune masses, but a radius larger than Jupiter. It is also located at the border of the Neptune desert, which describes the lack of highly-irradiated Neptune-sized planets, and which remains poorly understood. Its large scale height and bright host star make the transiting WASP-127b a valuable target to characterise in transmission spectroscopy. We use combined EulerCam and TESS light curves to recalculate the system's parameters. Additionally, we present an in-depth search for sodium in four transit observations of WASP-127b, obtained as part of the Hot Exoplanet Atmosphere Resolved with Transit Spectroscopy (HEARTS) survey with the High Accuracy Radial velocity Planet Searcher (HARPS) spectrograph. Two nights from this dataset were analysed independently by another team, claiming a detection of sodium incompatible with previous studies of data from both ground and space. We show that this large sodium detection is actually due to contamination from telluric sodium emissions and the low S/N in the core of the deep stellar sodium lines. When properly accounting for these effects, the previous sodium signal is reduced to an absorption of $0.46\pm0.20\%$ ($2.3\sigma$), which is compatible with analyses of WASP-127b transits carried out with other instruments. We can fit a Gaussian to the D2 line, however, the D1 line was not detected, indicating an unusual line ratio if sodium exists in the atmosphere. Follow-up of WASP-127 at both high-resolution and with high sensitivity will be required to firmly establish the presence of sodium and analyse its line shape. Comment: 11 pages, 11 figures, published in A&A

  • Publication . Article . Other literature type . Preprint . 2022
    Open Access English
    Authors: 
    Winkler, Manuela; Plichta, Roman; Buysse, Pauline; Lohila, Annalea; Spicher, Fabien; Boeckx, Pascal; Wild, Jan; Feigenwinter, Iris; Olejnik, Janusz; Risch, Anita; +347 more
    Countries: United Kingdom, Netherlands, Spain, France, United Kingdom, Switzerland, Netherlands, Belgium, Germany, Denmark ...
    Project: EC | LEAP-AGRI (727715), EC | FORMICA (757833), EC | SustainSAHEL (861974), EC | eLTER PLUS (871128), ANR | ODYSSEE (ANR-13-ISV7-0004), FCT | UIDP/50017/2020 (UIDP/50017/2020), SNSF | ICOS-CH Phase 2 (173691), UKRI | E3 - Edinburgh Earth and ... (NE/L002558/1), ANR | IMPRINT (ANR-19-CE32-0005), NSERC ,...

    JJL received funding from the Research Foundation Flanders (grant nr. 12P1819N). The project received funding from the Research Foundation Flanders (grants nrs, G018919N, W001919N). JVDH and TWC received funding from DOB Ecology. JA received funding from the University of Helsinki, Faculty of Science (MICROCLIM, grant nr. 7510145) and Academy of Finland Flagship (grant no. 337552). PDF, CM and PV received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (ERC Starting Grant FORMICA 757833). JK received funding from the Arctic Interactions at the University of Oulu and Academy of Finland (318930, Profi 4), Maaja vesitekniikan tuki ry., Tiina and Antti Herlin Foundation, Nordenskiold Samfundet and Societas pro Fauna et Flora Fennica. MK received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). TWC received funding from National Geographic Society grant no. 9480-14 and WW-240R-17. MA received funding from CISSC (program ICRP (grant nr:2397) and INSF (grant nr: 96005914). The Royal Botanic Garden Edinburgh is supported by the Scottish Government's Rural and Environment Science and Analytical Services Division. JMA received funding from the Funding Org. Qatar Petroleum (grant nr. QUEX-CAS-QP-RD-18/19). JMA received funding from the European Union's Horizon 2020 research and innovation program (grant no. 678841) and from the Swiss National Science Foundation (grant no. 31003A_176044). JA was supported by research grants LTAUSA19137 (program INTER-EXCELLENCE, subprogram INTER-ACTION) provided by Czech Ministry of Education, Youth and Sports and 20-05840Y of the Czech Science Foundation. AA was supported by the Ministry of Science and Higher Education of the Russian Federation (grant FSRZ-2020-0014). SN, UAT, JJA, and JvO received funding from the Independent Research Fund Denmark (7027-00133B). LvdB, KT, MYB and RC acknowledge funding from the German Research Foundation within the Priority Program SPP-1803 'EarthShape: Earth Surface Shaping by Biota' (grant TI 338/14-1&2 and BA 3843/6-1). PB was supported by grant project VEGA of the Ministry of Education of the Slovak Republic and the Slovak Academy of Sciences No. 2/0132/18. Forest Research received funding from the Forestry Commission (climate change research programme). JCB acknowledges the support of Universidad Javeriana. JLBA received funding from the Direccion General de Cambio Climatico del Gobierno de Aragon; JLBA acknowledges fieldwork assistance by Ana Acin, the Ordesa y Monte Perdido National Park, and the Servicio de Medio Ambiente de Soria de la Junta de Castilla y Leon. RGB and MPB received funding from BECC - Biodiversity and Ecosystem services in a Changing Climate. MPB received funding from The European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie Grant Agreement No. 657627 and The Swedish Research Council FORMAS - future research leaders No. 2016-01187. JB received funding from the Czech Academy of Sciences (grant nr. RVO 67985939). NB received funding from the SNF (grant numbers 40FA40_154245, 20FI21_148992, 20FI20_173691, 407340_172433) and from the EU (contract no. 774124). ICOS EU research infrastructure. EU FP7 NitroEurope. EU FP7 ECLAIRE. The authors from Biological Dynamics of Forest Fragments Project, PDBFF, Instituto Nacional de Pesquisas da Amazonia, Brazil were supported by the MCTI/CNPq/FNDCT - AcAo Transversal no68/2013 - Programa de Grande Escala da Biosfera-Atmosfera na Amazonia - LBA; Project 'Como as florestas da Amazonia Central respondem as variacoes climaticas? Efeitos sobre dinamica florestal e sinergia com a fragmentacAo florestal'. This is the study 829 of the BDFFP Technical Series. to The EUCFLUX Cooperative Research Program and Forest Science and Research Institute-IPEF. NC acknowledges funding by Stelvio National Park. JC was funded by the Spanish government grant CGL2016-78093-R. ANID-FONDECYT 1181745 AND INSTITUTO ANTARTICO CHILENO (INACH FR-0418). SC received funding from the German Research Foundation (grant no. DFG- FZT 118, 202548816). The National Science Foundation, Poland (grant no. UMO-2017/27/B/ST10/02228), within the framework of the 'Carbon dioxide uptake potential of sphagnum peatlands in the context of atmospheric optical parameters and climate changes' (KUSCO2) project. SLC received funding from the South African National Research Foundation and the Australian Research Council. FM, M, KU and MU received funding from Slovak Research and Development Agency (no. APVV-19-0319). Instituto Antartico Chileno (INACH_RT-48_16), Iniciativa Cientifica Milenio Nucleo Milenio de Salmonidos Invasores INVASAL, Institute of Ecology and Biodiversity (IEB), CONICYT PIA APOYO CCTE AFB170008. PC is supported by NERC core funding to the BAS 'Biodiversity, Evolution and Adaptation Team. EJC received funding from the Norwegian Research Council (grant number 230970). GND was supported by NERC E3 doctoral training partnership grant (NE/L002558/1) at the University of Edinburgh and the Carnegie Trust for the Universities of Scotland. Monitoring stations on Livingston Island, Antarctica, were funded by different research projects of the Gobern of Spain (PERMAPLANET CTM2009-10165-E; ANTARPERMA CTM2011-15565-E; PERMASNOW CTM2014-52021-R), and the PERMATHERMAL arrangement between the University of Alcala and the Spanish Polar Committee. GN received funding from the Autonomous Province of Bolzano (ITA). The infrastructure, part of the UK Environmental Change Network, was funded historically in part by ScotNature and NERC National Capability LTS-S: UK-SCAPE; NE/R016429/1). JD was supported by the Czech Science Foundation (GA17-19376S) and MSMT (LTAUSA18007). ED received funding from the Kempe Foundation (JCK-1112 and JCK-1822). The infrastructure was supported by the Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Programme I (NPU I), grant number LO1415 and by the project for national infrastructure support CzeCOS/ICOS Reg. No. LM2015061. NE received funding from the German Research Foundation (DFG- FZT 118, 202548816). BE received funding from the GLORIA-EU project no EVK2-CT2000-00056, the Autonomous Province of Bolzano (ITA), from the Tiroler Wissenschaftsfonds and from the University of Innsbruck. RME was supported by funding to the SAFE Project from the Sime Darby Foundation. OF received funding from the German Research Foundation (DFG- FZT 118, 202548816). EFP was supported by the Jardin Botanico Atlantico (SV-20-GIJON-JBA). MF was funded by the German Federal Ministry of Education and Research (BMBF) in the context of The Future Okavango (Grant No. 01LL0912) and SASSCAL (01LG1201M; 01LG1201N) projects. EFL received funding from ANID PIA / BASAL FB210006. RAG received funding from Fondecyt 11170516, CONICYT PIA AFB170008 and ANID PIA / BASAL FB210006. MBG received funding from National Parks (DYNBIO, #1656/2015) and The Spanish Research Agency (VULBIMON, #CGL2017-90040-R). MG received funding from the Swiss National Science Foundation (ICOS-CH Phase 2 20FI20_173691). FG received funding from the German Research Foundation (DFG- FZT 118, 202548816). KG and TS received funding from the UK Biotechnology and Biological Research Council (grant = 206/D16053). SG was supported by the Research Foundation Flanders (FWO) (project G0H1517N). KJ and PH received funding from the EU Horizon2020 INFRAIA project eLTER-PLUS (871128), the project LTER-CWN (FFG, F&E Infrastrukturforderung, project number 858024) and the Austrian Climate Research Program (ACRP7 - CentForCSink - KR14AC7K11960). SH and ARB received funding through iDiv funded by the German Research Foundation (DFG- FZT 118, 202548816). LH received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). MH received funding from the Baden-Wurttemberg Ministry of Science, Research and Arts via the project DRIeR (Drought impacts, processes and resilience: making the in-visible visible). LH received funding from International Polar Year, Weston Foundation, and ArcticNet. DH received funding from Natural Sciences and Engineering Council (Canada) (RGPIN-06691). TTH received funding from Independent Research Fund Denmark (grant no. 8021-00423B) and Villum Foundation (grant no. 17523). Ministry of Education, Youth and Sports of the Czech Republic (projects LM2015078, VAN2020/01 and CZ.02.1.01/0.0/0.0/16_013/0001708). KH, CG and CJD received funding from Bolin Centre for Climate Research, Stockholm University and from the Swedish research council Formas [grant n:o 2014-00530 to KH]. JJ received funding from the Funding Org. Swedish Forest Society Foundation (grant nr. 2018-485-Steg 2 2017) and Swedish Research Council FORMAS (grant nr. 2018-00792). AJ received funding from the German Federal Ministry of Education and Research BMBF (Grant Nr. FKZ 031B0516C SUSALPS) and the Oberfrankenstiftung (Grant Nr. OFS FP00237). ISJ received funding from the Energy Research Fund (NYR-11 - 2019, NYR-18 - 2020). TJ was supported by a UK NERC Independent Research Fellowship (grant number: NE/S01537X/1). RJ received funding from National Science Centre of Poland (grant number: 2016/21/B/ST10/02271) and Polish National Centre for Research and Development (grant number: Pol-Nor/203258/31/2013). VK received funding from the Czech Academy of Sciences (grant nr. RVO 67985939). AAK received funding from MoEFCC, Govt of India (AICOPTAX project F. No. 22018/12/2015/RE/Tax). NK received funding from FORMAS (grants nr. 2018-01781, 2018-02700, 2019-00836), VR, support from the research infrastructure ICOS-SE. BK received funding from the National Research, Development and Innovation Fund of Hungary (grant nr. K128441). Ministry of Education, Youth and Sports of the Czech Republic (projects LM2015078 and CZ.02.1.01/0.0/0.0/16_013/0001708). Project B1-RNM-163-UGR-18-Programa Operativo FEDER 2018, partially funded data collection. Norwegian Research Council (NORKLIMA grants #184912 and #244525) awarded to Vigdis Vandvik. MM received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). Project CONICYT-PAI 79170119 and ANID-MPG 190029 awarded to Roy Mackenzie. This work was partly funded by project MIUR PON Cluster OT4CLIMA. RM received funding from the SNF project number 407340_172433. FM received funding from the Stelvio National Park. PM received funding from AIAS-COFUND fellowship programme supported by the Marie Skodowska- Curie actions under the European Union's Seventh Framework Pro-gramme for Research, Technological development and Demonstration (grant agreement no 609033) and the Aarhus University Research Foundation, Denmark. RM received funding from the Ministry of Education, Youth and Sports of the Czech Republic (project LTT17033). SM and VM received funding from EU FP6 NitroEurope (grant nr. 17841), EU FP7 ECLAIRE (grant nr. 282910), the Ministry of Education and Science of Ukraine (projects nr. 505, 550, 574, 602), GEF-UNEP funded "Toward INMS" project (grant nr. NEC05348) and ENI CBC BSB PONTOS (grant nr. BSB 889). The authors from Biological Dynamics of Forest Fragments Project, PDBFF, Instituto Nacional de Pesquisas da Amazonia, Brazil were supported by the MCTI/CNPq/FNDCT - AcAo Transversal no68/2013 - Programa de Grande Escala da Biosfera-Atmosfera na Amazonia - LBA; Project 'Como as florestas da Amazonia Central respondem as variacoes climaticas? Efeitos sobre dinamica florestal e sinergia com a fragmentacAo florestal'. FJRM was financially supported by the Netherlands Organization for Scientific Research (VICI grant 016.VICI.170.072) and Research Foundation Flanders (FWO-SBO grant S000619N). STM received funding from New Frontiers in Research Fund-Exploration (grant nr. NFRF-2018-02043) and NSERC Discovery. MMR received funding from the Australian Research Council Discovery Early Career Research Award (grant nr. DE180100570). JAM received funding from the National Science Foundation (DEB 1557094), International Center for Advanced Renewable Energy and Sustainability (I-CARES) at Washington University in St. Louis, ForestGEO, and Tyson Research Center. IM-S was funded by the UK Natural Environment Research Council through the ShrubTundra Project (NE/M016323/1). MBN received funding from FORMAS, VR, Kempe Foundations support from the research infrastructures ICOS and SITES. MDN received funding from CONICET (grant nr. PIP 112-201501-00609). Spanish Ministry of Science grant PID2019-110521GB-I00 and Catalan government grant 2017-1005. French National Research Agency (ANR) in the frame of the Cluster of Excellence COTE (project HydroBeech, ANR-10-LABX-45). VLIR-OUS, under the Institutional University Coorperation programme (IUC) with Mountains of the Moon University. Project LAS III 77/2017/B entitled: \"Estimation of net carbon dioxide fluxes exchanged between the forest ecosystem on post-agricultural land and between the tornado-damaged forest area and the atmosphere using spectroscopic and numerical methods\", source of funding: General Directorate of State Forests, Warsaw, Poland. Max Planck Society (Germany), RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science, project number 20-45-242908. Estonian Research Council (PRG609), and the European Regional Development Fund (Centre of Excellence EcolChange). Canada-Denmark Arctic Research Station Early Career Scientist Exchange Program, from Polar knowledge Canada (POLAR) and the Danish Agency for Science and Higher Education. AP received funding from Fondecyt 1180205, CONICYT PIA AFB170008 and ANID PIA / BASAL FB210006. MP received funding from the Funding Org. Knut and Alice Wallenberg Foundation (grant nr. 2015.0047), and acknowledges funding from the Swedish Research Council (VR) with contributing research institutes to both the SITES and ICOS Sweden infrastructures. JP and RO were funded by the Spanish Ministry of Science grant PID2019-110521GB-I00, the fundacion Ramon Areces grant ELEMENTAL-CLIMATE, and the Catalan government grant 2017-1005. MPB received funding from the Svalbard Environmental Protection Fund (grant project number 15/128) and the Research Council of Norway (Arctic Field Grant, project number 269957). RP received funding from the Ministry of Education, Youth and Sports of the Czech Republic (grant INTER-TRANSFER nr. LTT20017). LTSER Zone Atelier Alpes; Federation FREE-Alpes. RP received funding from a Humboldt Fellowship for Experienced Researchers. Prokushkin AS and Zyryanov VI contribution has been supported by the RFBR grant #18-05-60203-Arktika. RPu received founding from the Polish National Science Centre (grant project number 2017/27/B/NZ8/00316). ODYSSEE project (ANR-13-ISV7-0004, PN-II-ID-JRP-RO-FR-2012). KR was supported through an Australian Government Research Training Program Scholarship. Fieldwork was supported by the Global Challenges program at the University of Wollongong, the ARC the Australian Antarctic Division and INACH. DR was funded by the project SUBANTECO IPEV 136 (French Polar Institute Paul-Emile Victor), Zone Atelier CNRS Antarctique et Terres Australes, SAD Region Bretagne (Project INFLICT), BiodivERsa 2019-2020 BioDivClim call 'ASICS' (ANR-20-EBI5-0004). SAR received funding from the Australian Research Council. NSF grant #1556772 to the University of Notre Dame. Pavia University (Italy). OR received funding from EU-LEAP-Agri (RAMSES II), EU-DESIRA (CASSECS), EU-H2020 (SustainSahel), AGROPOLIS and TOTAL Foundations (DSCATT), CGIAR (GLDC). AR was supported by the Russian Science Foundation (Grant 18-74-10048). Parc national des Ecrins. JS received funding from Vetenskapsradet grant nr (No: 2014-04270), ALTER-net multi-site grant, River LIFE project (LIFE08 NAT/S/000266), Flexpeil. Helmholtz Association long-term research program TERENO (Terrestrial Environmental Observatories). PS received funding from the Polish Ministry of Science and Higher Education (grant nr. N N305 304840). AS acknowledges funding by ETH Zurich project FEVER ETH-27 19-1. LSC received funding from NSERC Canada Graduate Scholarship (Doctoral) Program; LSC was also supported by ArcticNet-NCE (insert grant #). Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (141513/2017-9); FundacAo Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (E26/200.84/2019). ZS received funding from the SRDA (grants nos. APVV-16-0325 and APVV-20-0365) and from the ERDF (grant no. ITMS 313011S735, CE LignoSilva). JS, MB and CA received funding from core budget of ETH Zurich. State excellence Program M-V \"WETSCAPES\". AfricanBioServices project funded by the EU Horizon 2020 grant number 641918. The authors from KIT/IMK-IFU acknowledge the funding received within the German Terrestrial Environmental Observatories (TERENO) research program of the Helmholtz Association and from the Bavarian Ministry of the Environment and Public Health (UGV06080204000). Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), project number 192626868, in the framework of the collaborative German-Indonesian research project CRC 990 (SFB): 'EFForTS, Ecological and Socioeconomic Functions of Tropical Lowland Rainforest Transformation Systems (Sumatra, Indonesia)'. MS received funding from the Ministry of Education, Youth and Sports of the Czech Republic (grant nr. INTER-TRANSFER LTT19018). TT received funding from the Swedish National Space Board (SNSB Dnr 95/16) and the CASSECS project supported by the European Union. HJDT received funding from the UK Natural Environment Research Council (NERC doctoral training partnership grant NE/L002558/1). German Science Foundation (DFG) GraKo 2010 \"Response\". PDT received funding from the MEMOIRE project (PN-III-P1-1.1-PD2016-0925). Arctic Challenge for Sustainability II (ArCS II; JPMXD1420318865). JU received funding from Czech Science Foundation (grant nr. 21-11487S). TU received funding from the Romanian Ministry of Education and Research (CCCDI - UEFISCDI -project PN-III-P2-2.1-PED-2019-4924 and PN2019-2022/19270201-Ctr. 25N BIODIVERS 3-BIOSERV). AV acknowledge funding from RSF, project 21-14-00209. GFV received funding from the Dutch Research Council NWO (Veni grant, no. 863.14.013). Australian Research Council Discovery Early Career Research Award DE140101611. FGAV received funding from the Portuguese Science Foundation (FCT) under CEECIND/02509/2018, CESAM (UIDP/50017/2020+UIDB/50017/2020), FCT/MCTES through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020. Ordesa y Monte Perdido National Park. MVI received funding from the Spanish Ministry of Science and Innovation through a doctoral grant (FPU17/05869). JW received funding from the Czech Science Foundation (grant nr. 20-28119S) and the Czech Academy of Sciences (grant nr. RVO 67985939). CR and SW received funding from the Swiss Federal Office for the Environment (FOEN) and the de Giacomi foundation. YY received funding from the National Natural Science Foundation of China (Grant no. 41861134039 and 41941015). ZY received funding from the National Natural Science Foundation of China (grant nr. 41877458). FZ received funding from the Swiss National Science Foundation (grant nr. 172198 and 193645). PZ received funding from the Funding Org. Knut and Alice Wallenberg Foundation (grant no. 2015.0047). JL received funding from (i) the Agence Nationale de la Recherche (ANR), under the framework of the young investigators (JCJC) funding instrument (ANR JCJC Grant project NoANR-19-CE32-0005-01: IMPRINT) (ii) the Centre National de la Recherche Scientifique (CNRS) (Defi INFINITI 2018: MORFO); and the Structure Federative de Recherche (SFR) Condorcet (FR CNRS 3417: CREUSE). Fieldwork in the Arctic got facilitated by funding from the EU INTERACT program. SN, UAT, JJA and JvO would like to thank the field team of the Vegetation Dynamics group for their efforts and hard work. We acknowledge Dominique Tristan for letting access to the field. For the logistic support the crew of INACH and Gabriel de Castilla Station team on Deception Island. We thank the Inuvialuit and Kluane First Nations for the opportunity to work on their land. MAdP acknowledges fieldwork assistance and logistics support to Unidad de Tecnologia Marina CSIC, and the crew of Juan Carlos I and Gabriel de Castilla Spanish Antarctic Stations, as well as to the different colleagues from UAH that helped on the instrument maintenance. ERF acknowledges fieldwork assistance by Martin Heggli. MBG acknowledges fieldwork and technical assistance by P Abadia, C Benede, P Bravo, J Gomez, M Grasa, R Jimenez, H Miranda, B Ponz, J Revilla and P Tejero and the Ordesa and Monte Perdido National Park staff. LH acknowledges field assistance by John Jacobs, Andrew Trant, Robert Way, Darroch Whitaker; we acknowledge the Inuit of Nunatsiavut, and the Co-management Board of Torngat Mountains National Park for their support of this project and acknowledge that the field research was conducted on their traditional lands. We thank our many bear guides, especially Boonie, Eli, Herman, John and Maria Merkuratsuk. AAK acknowledges field support of Akhtar Malik, Rameez Ahmad. Part of microclimatic records from Saxony was funded by the Saxon Switzerland National Park Administration. Tyson Research Center. JP acknowledges field support of Emmanuel Malet (Edytem) and Rangers of Reserves Naturelles de Haute-Savoie (ASTERS). Practical help: Roel H. Janssen, N. Huig, E. Bakker, Schools in the tepaseforsoket, Forskar fredag, Erik Herberg. The support by the Bavarian Forest National Park administration is highly appreciated. LvdB acknowledges CONAF and onsite support from the park rangers from PN Pan de Azucar, PN La Campana, PN Nahuelbuta and from communidad agricola Quebrada de Talca. JL and FS acknowledge Manuel Nicolas and all forest officers from the Office National des Forets (ONF) who are in charge of the RENECOFOR network and who provided help and local support for the installation and maintenance of temperature loggers in the field. Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1-km2 resolution for 0–5 and 5–15 cm soil depth. These maps were created by calculating the difference (i.e. offset) between in situ soil temperature measurements, based on time series from over 1200 1-km2 p ixels ( summarized f rom 8 519 u nique t emperature sensors) across all the world's major terrestrial biomes, and coarse-grained air temperature estimates from ERA5-Land (an atmospheric reanalysis by the European Centre for Medium-Range Weather Forecasts). We show that mean annual soil temperature differs markedly from the corresponding gridded air temperature, by up to 10°C (mean = 3.0 ± 2.1°C), with substantial variation across biomes and seasons. Over the year, soils in cold and/or dry biomes are substantially warmer (+3.6 ± 2.3°C) than gridded air temperature, whereas soils in warm and humid environments are on average slightly cooler (−0.7 ± 2.3°C). The observed substantial and biome-specific offsets emphasize that the projected impacts of climate and climate change on near-surface biodiversity and ecosystem functioning are inaccurately assessed when air rather than soil temperature is used, especially in cold environments. The global soil-related bioclimatic variables provided here are an important step forward for any application in ecology and related disciplines. Nevertheless, we highlight the need to fill remaining geographic gaps by collecting more in situ measurements of microclimate conditions to further enhance the spatiotemporal resolution of global soil temperature products for ecological applications. AIAS-COFUND fellowship programme - Marie Skodowska- Curie actions under the European Union's Seventh Framework Pro-gramme for Research, Technological development and Demonstration 609033 European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie Grant 657627 SNF 407340_172433 40FA40_154245 20FI21_148992 20FI20_173691 Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (UEFISCDI) PN-III-P2-2.1-PED-2019-4924 PN2019-2022/19270201 Project 'Como as florestas da Amazonia Central respondem as variacoes climaticas? Efeitos sobre dinamica florestal e sinergia com a fragmentacAo florestal' Ministry of Education, Youth & Sports - Czech Republic LM2015078 VAN2020/01 CZ.02.1.01/0.0/0.0/16_013/0001708 LTT17033 LTT20017 INTER-TRANSFER LTT19018 Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Programme I (NPU I) LO1415 International Center for Advanced Renewable Energy and Sustainability (I-CARES) at Washington University in St. Louis Bavarian Ministry of the Environment and Public Health UGV06080204000 German Research Foundation (DFG) 192626868 French National Research Agency (ANR) ANR-19-CE32-0005-01 Centre National de la Recherche Scientifique (CNRS) Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) PIA APOYO CCTE AFB170008 PIA AFB170008 grant project VEGA of the Ministry of Education of the Slovak Republic Slovak Academy of Sciences 2/0132/18 Portuguese Foundation for Science and Technology CEECIND/02509/2018 CESAM UIDP/50017/2020+UIDB/50017/2020 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 11170516 1180205 Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) E26/200.84/2019 German Terrestrial Environmental Observatories (TERENO) research program of the Helmholtz Association Kempe Foundations - research infrastructure ICOS Kempe Foundations - research infrastructure SITES Gobern of Spain PERMAPLANET CTM2009-10165-E ANTARPERMA CTM2011-15565-E PERMASNOW CTM2014-52021-R project for national infrastructure support CzeCOS/ICOS LM2015061 GLORIA-EU EVK2-CT2000-00056 German Research Foundation (DFG) DFG- FZT 118 202548816 TI 338/14-1 TI 338/14-2 BA 3843/6-1 Swedish Research Council Swedish Research Council Formas 2014-00530 2018-00792 2016-01187 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) PIP 112-201501-00609 NERC E3 doctoral training partnership grant at the University of Edinburgh NE/L002558/1 Biotechnology and Biological Sciences Research Council (BBSRC) 206/D16053 FWO G0H1517N UK Natural Environment Research Council through the ShrubTundra Project NE/M016323/1 Scottish Government's Rural and Environment Science and Analytical Services Division Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 141513/2017-9 National Natural Science Foundation of China (NSFC) 41861134039 41941015 41877458 Ministry of Science and Higher Education of the Russian Federation FSRZ-2020-0014 Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-06691 Grant Agency of the Czech Republic 20-28119S 20-05840Y GA17-19376S 21-11487S Federal Ministry of Education & Research (BMBF) 01LL0912 01LG1201M 01LG1201N Polish National Centre for Research and Development Pol-Nor/203258/31/2013 Structure Federative de Recherche (SFR) Condorcet (FR CNRS 3417: CREUSE) Krasnoyarsk Territory Krasnoyarsk Regional Fund of Science 20-45-242908 Netherlands Organization for Scientific Research (NWO) 016.VICI.170.072 Austrian Climate Research Program ACRP7 - CentForCSink - KR14AC7K11960 National Research, Development and Innovation Fund of Hungary K128441 Federal Ministry of Education & Research (BMBF) FKZ 031B0516C SUSALPS project SUBANTECO IPEV 136 (French Polar Institute Paul-Emile Victor) EU-LEAP-Agri (RAMSES II) EU-DESIRA (CASSECS) EU-H2020 (SustainSahel) Portuguese Foundation for Science and Technology European Commission European Union's Horizon 2020 research and innovation program 678841 Natural Sciences and Engineering Research Council of Canada (NSERC) Ministry of Education, Youth & Sports - Czech Republic LTAUSA18007 Ministry of Education, Youth & Sports - Czech Republic LTAUSA19137 ALTER-net multi-site grant, River LIFE project LIFE08 NAT/S/000266 Netherlands Organization for Scientific Research (NWO) 863.14.013 Russian Foundation for Basic Research (RFBR) 18-05-60203-Arktika Arctic Challenge for Sustainability II (ArCS II) JPMXD1420318865 BECC - Biodiversity and Ecosystem services in a Changing Climate Swedish Research Council Formas 2018-01781 2018-02700 2019-00836 Smithsonian Institution Smithsonian Tropical Research Institute Ministry of Science and Higher Education, Poland N N305 304840 University of Helsinki, Faculty of Science (MICROCLIM) 7510145 BiodivERsa 2019-2020 BioDivClim call 'ASICS' ANR-20-EBI5-0004 iDiv by the German Research Foundation DFG- FZT 118 202548816 MoEFCC, Govt of India (AICOPTAX project) 22018/12/2015/RE/Tax Direccion General de Cambio Climatico del Gobierno de Aragon National Science Foundation, Poland UMO-2017/27/B/ST10/02228 Ministry of Education and Science of Ukraine 505 550 574 602 Norwegian Research Council (NORKLIMA grants) 184912 244525 New Frontiers in Research Fund-Exploration NFRF-2018-02043 ODYSSEE project (PN-II-ID-JRP-RO-FR-2012) ANR-13-ISV7-0004 Independent Research Fund Denmark 8021-00423B 7027-00133B Global Challenges program at the University of Wollongong project LTER-CWN (FFG, F&E Infrastrukturforderung) 858024 Instituto Antartico Chileno INACH_RT-48_16 INACH FR-0418 Baden-Wurttemberg Ministry of Science, Research and Arts Swedish Research Council Formas Swedish Research Council Natural Environment Research Council (NERC) NE/L002558/1 Bolin Centre for Climate Research, Stockholm University Swedish Forest Society Foundation 2018-485-Steg 2 2017 Swiss National Science Foundation (SNSF) 20FI20_173691 Co-management Board of Torngat Mountains National Park NERC National Capability LTS-S: UK-SCAPE NE/R016429/1 UK NERC Independent Research Fellowship NE/S01537X/1 General Directorate of State Forests, Warsaw, Poland French National Research Agency (ANR) ANR-10-LABX-45 National Science Centre, Poland 2016/21/B/ST10/02271 NSERC Canada Graduate Scholarship (Doctoral) Program Consiliul National al Cercetarii Stiintifice (CNCS) Slovak Research and Development Agency APVV-19-0319 Spanish Research Agency (VULBIMON) CGL2017-90040-R Polish National Science Centre 2017/27/B/NZ8/00316 Zone Atelier CNRS Antarctique et Terres Australes Energy Research Fund NYR-11 - 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Svalbard Environmental Protection Fund 15/128 Russian Science Foundation (RSF) 18-74-10048 Knut & Alice Wallenberg Foundation 2015.0047 Bavarian Forest National Park administration Russian Foundation for Basic Research (RFBR) National Research Foundation - South Africa Natural Environment Research Council (NERC) National Science Foundation (NSF) 1556772 MEMOIRE project PN-III-P1-1.1-PD2016-0925 Jardin Botanico Atlantico SV-20-GIJON-JBA Swedish National Space Board (SNSB) 95/16 Swiss National Science Foundation (SNSF) Spanish Government PID2019-110521GB-I00 Australian Research Council DE180100570 Australian Research Council DE140101611 Czech Academy of Sciences RVO 67985939 SAD Region Bretagne (Project INFLICT) CASSECS project by the European Union ARC the Australian Antarctic Division Autonomous Province of Bolzano (ITA) Qatar Petroleum QUEX-CAS-QP-RD-18/19 ERDF (CE LignoSilva) ITMS 313011S735 European Commission CGL2016-78093-R Societas pro Fauna et Flora Fennica Swedish Research Council 2014-04270 Kempe Foundation JCK-1112 JCK-1822 project MIUR PON Cluster OT4CLIMA Research Council of Norway 269957 Tiina and Antti Herlin Foundation National Parks (DYNBIO) 1656/2015 Academy of Finland 318930 337552 European Commission 17841 774124 Estonian Research Council PRG609 research infrastructure ICOS-SE UK Research & Innovation (UKRI) Oberfrankenstiftung OFS FP00237 SRDA APVV-16-0325 APVV-20-0365 Spanish Government FPU17/05869 FWO G018919N W001919N 12P1819N Maaja vesitekniikan tuki ry. 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  • Open Access
    Authors: 
    Andreea Manole; Stephanie Efthymiou; Emer O'Connor; Marisa I. Mendes; Matthew J. Jennings; Reza Maroofian; Indran Davagnanam; Kshitij Mankad; Maria Rodriguez Lopez; Vincenzo Salpietro; +82 more
    Publisher: Elsevier BV
    Countries: Netherlands, France, Turkey
    Project: WT | Strengthening the neuromu... (201064), EC | HUCNC (249968), WT | Exploring novel molecular... (109915), UKRI | MRC Centre for Neuromuscu... (G0601943), ANR | UNISTRA (ANR-10-IDEX-0002), EC | REVERSIBLECOX (309548)

    Aminoacyl-tRNA synthetases (ARSs) are ubiquitous, ancient enzymes that charge amino acids to cognate tRNA molecules, the essential first step of protein translation. Here, we describe 32 individuals from 21 families, presenting with microcephaly, neurodevelopmental delay, seizures, peripheral neuropathy, and ataxia, with de novo heterozygous and bi-allelic mutations in asparaginyl-tRNA synthetase (NARS1). We demonstrate a reduction in NARS1 mRNA expression as well as in NARS1 enzyme levels and activity in both individual fibroblasts and induced neural progenitor cells (iNPCs). Molecular modeling of the recessive c.1633C>T (p.Arg545Cys) variant shows weaker spatial positioning and tRNA selectivity. We conclude that de novo and bi-allelic mutations in NARS1 are a significant cause of neurodevelopmental disease, where the mechanism for de novo variants could be toxic gain-of-function and for recessive variants, partial loss-of-function.

  • Publication . Other literature type . Article . 2018
    Open Access English
    Authors: 
    Alessandro Genoni; Lukáš Bučinský; Nicolas Claiser; Julia Contreras-García; Birger Dittrich; Paulina M. Dominiak; Enrique Espinosa; Carlo Gatti; Paolo Giannozzi; Jean-Michel Gillet; +12 more
    Publisher: Wiley-VCH Verlag
    Countries: France, Sweden, Italy, Italy
    Project: SNSF | Physical and chemical pro... (160157), ARC | Interatomic bonding in al... (FT110100427), NSERC , ANR | HalX-Bond (ANR-08-BLAN-0091), ANR | QuMacroRef (ANR-17-CE29-0005), EC | MaX (676598)

    International audience; Crystallography and quantum mechanics have always been tightly connected because reliable quantum mechanical models are needed to determine crystal structures. Due to this natural synergy, nowadays accurate distributions of electrons in space can be obtained from diffraction and scattering experiments. In the original definition of quantum crystallography (QCr) given by Massa, Karle and Huang, direct extraction of wavefunctions or density matrices from measured intensities of reflections or, conversely, ad hoc quantum mechanical calculations to enhance the accuracy of the crystallographic refinement are implicated. Nevertheless, many other active and emerging research areas involving quantum mechanics and scattering experiments are not covered by the original definition although they enable to observe and explain quantum phenomena as accurately and successfully as the original strategies. Therefore, we give an overview over current research that is related to a broader notion of QCr, and discuss options how QCr can evolve to become a complete and independent domain of natural sciences. The goal of this paper is to initiate discussions around QCr, but not to find a final definition of the field.

  • Open Access English
    Authors: 
    Leonid L. Rubchinsky; Sungwoo Ahn; Wouter Klijn; Ben Cumming; Stuart Yates; Vasileios Karakasis; Alexander Peyser; Marmaduke Woodman; Sandra Diaz-Pier; James Deraeve; +193 more
    Countries: France, Italy
    Project: UKRI | A scalable chip multiproc... (EP/D07908X/1), NSF | Cellular mechanisms of th... (0750456), NIH | From Cells to Systems and... (5R90DA033462-03), EC | SpikeControl (658479), CIHR , WT , ANR | PSL (ANR-10-IDEX-0001), UKRI | Biologically-Inspired Mas... (EP/G015740/1), EC | INDIREA (606901), EC | M4 (323711),...

    International audience; No abstract available

  • Open Access English
    Authors: 
    Anke Arentsen; Else Starkenburg; Nicolas F. Martin; Vanessa Hill; Rodrigo A. Ibata; Andrea Kunder; Mathias Schultheis; K. A. Venn; Daniel B. Zucker; David Aguado; +13 more
    Publisher: HAL CCSD
    Countries: Italy, Canada, Switzerland, France
    Project: NSF | Pan-STARRS1: Operations; ... (1238877), ANR | Pristine (ANR-18-CE31-0017), ARC | Discovery Projects - Gran... (DP180101791), SNSF | Globular clusters or dwar... (168065), EC | OPTICON (730890)

    Our Galaxy is known to contain a central boxy/peanut-shaped bulge, yet the importance of a classical, pressure-supported component within the central part of the Milky Way is still being debated. It should be most visible at low metallicity, a regime that has not yet been studied in detail. Using metallicity-sensitive narrow-band photometry, the Pristine Inner Galaxy Survey (PIGS) has collected a large sample of metal-poor ([Fe/H] < -1.0) stars in the inner Galaxy to address this open question. We use PIGS to trace the metal-poor inner Galaxy kinematics as function of metallicity for the first time. We find that the rotational signal decreases with decreasing [Fe/H], until it becomes negligible for the most metal-poor stars. Additionally, the velocity dispersion increases with decreasing metallicity for -3.0 < [Fe/H] < -0.5, with a gradient of -44 $\pm$ 4 km$\,$s$^{-1}\,$dex$^{-1}$. These observations may signal a transition between Galactic components of different metallicities and kinematics, a different mapping onto the boxy/peanut-shaped bulge for former disk stars of different metallicities and/or the secular dynamical and gravitational influence of the bar on the pressure-supported component. Our results provide strong constraints on models that attempt to explain the properties of the inner Galaxy. 5 pages + appendices, accepted to MNRAS Letters

  • Open Access
    Authors: 
    R. Akutsu; C. Alt; S. Ban; Gareth J. Barker; G.D. Barr; C. Barry; A. Beloshapkin; F. Bench; Vincenzo Berardi; S. Berkman; +181 more
    Publisher: American Physical Society (APS)
    Project: NSERC , EC | SK2HK (872549), EC | JENNIFER2 (822070), EC | INPhINIT (713673), ANR | SUNCORE (ANR-19-CE31-0001), EC | FELLINI (754496)

    We thank the J-PARC staff for superb accelerator performance. We thank the CERN NA61/SHINE Collaboration for providing valuable particle production data. We acknowledge the support of MEXT, Japan; NSERC (Grant No. SAPPJ-2014-00031), the NRC and CFI, Canada; the CEA and CNRS/IN2P3, France; the DFG, Germany; the INFN, Italy; the National Science Centre and Ministry of Science and Higher Education, Poland; the RSF (Grant No. 19-12-00325) and the Ministry of Science and Higher Education, Russia; MINECO and ERDF funds, Spain; the SNSF and SERI, Switzerland; the STFC, UK; and the DOE, USA. We also thank CERN for the UA1/NOMAD magnet, DESY for the HERA-B magnet mover system, NII for SINET4, the WestGrid and SciNet consortia in Compute Canada, and GridPP in the United Kingdom. In addition, participation of individual researchers and institutions has been further supported by funds from the ERC (FP7), “la Caixa” Foundation (ID 100010434, fellowship code LCF/BQ/IN17/11620050), the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska- Curie Grants Agreement No. 713673 and No. 754496, and H2020 Grant No. RISE-GA822070-JENNIFER2 2020 and No. RISE-GA872549-SK2HK; the JSPS, Japan; the Royal Society, UK; French ANR Grant No. ANR-19- CE31-0001; and the DOE Early Career programme, USA.