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Cet article analyse l’évolution de la participation des femmes aux structures dirigeantes des associations. Les femmes apparaissent largement en retrait des fonctions de président d’association et leur accession aux postes de dirigeants s’effectue principalement à partir des associations créées récemment et dans des types d’associations orientées vers des populations fragiles ou vulnérables. L’article montre que l’on peut imputer leur plus forte présence essentiellement aux évolutions sociétales en cours depuis les années 70 : activité croissante des femmes, hausse de leur qualification, démocratisation de la société et de la vie associative, ouverture plus grande des associations récentes aux plus jeunes et à des catégories sociales plus variées. This article examines the evolution of the participation of women in the governing bodies of nonprofit organizations. There appear to be very few women CEOs in nonprofit organizations, and women who have reached executive positions have mainly done so in recently created nonprofit organizations and those concerned with people at risk and vulnerable social groups. The article shows that the increase is essentially due to societal changes since the 1970s: growing female participation in the workforce, their higher level of education, democratization of society and nonprofit organizations, and recent nonprofit organizations more open to younger people and a broader cross-section of the population.

Let k be a base field, K be a field containing k and L/K be a field extension of degree n. The essential dimension ed(L/K) over k is a numerical invariant measuring "the complexity" of L/K. Of particular interest is $\tau$(n) = max { ed(L/K) | L/K is a separable extension of degree n}, also known as the essential dimension of the symmetric group $S_n$. The exact value of $\tau$(n) is known only for n $\leq$ 7. In this paper we assume that k is a field of characteristic p > 0 and study the essential dimension of inseparable extensions L/K. Here the degree n = [L:K] is replaced by a pair (n, e) which accounts for the size of the separable and the purely inseparable parts of L/K respectively, and \tau(n) is replaced by $\tau$(n, e) = max { ed(L/K) | L/K is a field extension of type (n, e)}. The symmetric group $S_n$ is replaced by a certain group scheme $G_{n,e}$ over k. This group is neither finite nor smooth; nevertheless, computing its essential dimension turns out to be easier than computing the essential dimension of $S_n$. Our main result is a simple formula for \tau(n, e). Comment: 18 pages

Dam building and reservoir operations alter the downstream hydrological regime, and as a result, affect the health of the river aquatic ecosystem, particularly for large-scale cascade reservoirs. This study investigated the impact of the Gezhouba Reservoir (GR) and the Three Gorges Reservoir (TGR) on the spawning conditions of two critical taxa, i.e., the endemic four major carps and the endangered Chinese sturgeon in the Yangtze River. We analyzed the flow, sediment, and thermal regime in these two taxa spawning seasons and compared their features between the predam and postdam periods. Our results revealed that the GR and the TGR had altered the frequency distributions of flow, sediment, and water temperature to different degrees, with the impact by the GR on the carps and Chinese sturgeon ranked as water temperature > water temperature. For the GR, the satisfying degree of the suitable flow and water temperature of the carps increased, whilst the suitable flow, sediment, and water temperature for the Chinese sturgeon decreased. These changes in TGR showed a significant ascending (descending) trend in the suitable flow (water temperature) for the carps, and a clear decreasing trend in the flow, sediment, and temperature for Chinese sturgeon. Both the TGR and the GR had negative impacts on the spawning of these two taxa in terms of the rising/falling flow characteristics. flow, and the effect of the TGR on these two taxa were ordered as flow > water temperature, sediment > water temperature > flow, sediment > flow >

Chronic limb ischemia, a complication commonly observed in conjunction with cardiovascular disease, is characterized by insufficient neovascularization despite the up-regulation of pro-angiogenic mediators. One hypothesis is that ischemia induces inhibitory signals that circumvent the normal capillary growth response. FoxO transcription factors exert anti-proliferative and pro-apoptotic effects on many cell types. We studied the regulation of FoxO1 protein in ischemic rat skeletal muscle following iliac artery ligation and in cultured endothelial cells. We found that FoxO1 expression was increased in capillaries within ischemic muscles compared with those from rats that underwent a sham operation. This finding correlated with increased expression of p27(Kip1) and reduced expression of Cyclin D1. Phosphorylated Akt was reduced concurrently with the increase in FoxO1 protein. In skeletal muscle endothelial cells, nutrient stress as well as lack of shear stress stabilized FoxO1 protein, whereas shear stress induced FoxO1 degradation. Endogenous FoxO1 co-precipitated with the E3 ubiquitin ligase murine double minute-2 (Mdm2) in endothelial cells, and this interaction varied in direct relation to the extent of Akt and Mdm2 phosphorylation. Moreover, ischemic muscles had a decreased level of Mdm2 phosphorylation and a reduced interaction between Mdm2 and FoxO1. Our results provide novel evidence that the Akt-Mdm2 pathway acts to regulate endothelial cell FoxO1 expression and illustrate a potential mechanism underlying the pathophysiological up-regulation of FoxO1 under ischemic conditions.

An advanced fixed sectional aerosol dynamics model describing the evolution of soot particles under simultaneous nucleation, coagulation, surface growth and oxidation processes is successfully implemented to model soot formation in a two-dimensional laminar axisymmetric coflow methane/air diffusion flame. This fixed sectional model takes into account soot aggregate formation and is able to provide soot aggregate and primary particle size distributions. Soot nucleation, surface growth and oxidation steps are based on the model of Fairweather et al. Soot equations are solved simultaneously to ensure convergence. The numerically calculated flame temperature, species concentrations and soot volume fraction are in good agreement with the experimental data in the literature. The structures of soot aggregates are determined by the nucleation, coagulation, surface growth and oxidation processes. The result of the soot aggregate size distribution function shows that the aggregate number density is dominated by sma...

Abstract While genome-wide surveys of abundance and diversity of mobile elements have been conducted for some class I transposable element families, little is known about the nature of class II transposable elements on this scale. In this report, we present the results from analysis of the sequence and structural diversity of Mutator-like elements (MULEs) in the genome of Arabidopsis thaliana (Columbia). Sequence similarity searches and subsequent characterization suggest that MULEs exhibit extreme structure, sequence, and size heterogeneity. Multiple alignments at the nucleotide and amino acid levels reveal conserved, potentially transposition-related sequence motifs. While many MULEs share common structural features to Mu elements in maize, some groups lack characteristic long terminal inverted repeats. High sequence similarity and phylogenetic analyses based on nucleotide sequence alignments indicate that many of these elements with diverse structural features may remain transpositionally competent and that multiple MULE lineages may have been evolving independently over long time scales. Finally, there is evidence that MULEs are capable of the acquisition of host DNA segments, which may have implications for adaptive evolution, both at the element and host levels.

Abstract Background Alberta Health Services identified that tertiary sites are often in overcapacity (admitted patients exceeding inpatient beds) while regional sites have low occupancy in their pediatric inpatient units. Hospital overcapacity may have negative effects on the care received by patients, such as increased risk of infection, less time spent with each patient and increased stress on the hospital staff (Keegan, 2010). In addition, rural families face several barriers to access to health care including traveling long distances to access the sub-specialty care present in urban tertiary centers. Previous studies conducted by our team found that transfers back to regional sites are not common. Increasing transfers of pediatric patients from tertiary to regional sites with care supported by the tertiary site could aid in addressing tertiary overcapacity and enable patients and families to receive care closer to home. Objectives This qualitative study sought to understand tertiary site health care professionals’ perceptions of tertiary to regional inpatient transfer. Design/Methods Four semi-structured focus groups were held with health care professionals. Focus groups included a mixed group of staff physicians, residents, nurses and managers. Common themes of discussion included the current transfer process, understanding of regional site resources and ways to increase patient transfer. A qualitative data analysis software, NVivo 11, was used to code, organize, and manage the data to facilitate data interpretations and generate themes regarding the current patient transfer process. Results The main barriers of pediatric transfer to rural sites include a lack of standardized transfer guidelines, limited understanding of rural regional site resources and mistrust between medical teams that prohibit patient transfer. The most likely pediatric patients that could be transferred back to rural sites include clearly diagnosed, single body system patients. Participants who had previous experience working in regional sites were more comfortable with transfer to regional sites. Transfer to regional sites could be increased by improving communication between medical teams and correcting misinformation about regional inpatient pediatric sites. Conclusion There is a historical practice of concentrating resources at tertiary care sites. However, there are a lack of shared guidelines for transfer as well as well as limited knowledge of regional site capabilities. Health care professionals across the entire continuum of patient care recognize the need to find solutions that would aid in transfer.

The hippocampus is an area of the brain that undergoes dramatic plasticity in response to experience and hormone exposure. The hippocampus retains the ability to produce new neurones in most mammalian species and is a structure that is targeted in a number of neurodegenerative and neuropsychiatric diseases, many of which are influenced by both sex and sex hormone exposure. Intriguingly, gonadal and adrenal hormones affect the structure and function of the hippocampus differently in males and females. Adult neurogenesis in the hippocampus is regulated by both gonadal and adrenal hormones in a sex- and experience-dependent way. Sex differences in the effects of steroid hormones to modulate hippocampal plasticity should not be completely unexpected because the physiology of males and females is different, with the most notable difference being that females gestate and nurse the offspring. Furthermore, reproductive experience (i.e. pregnancy and mothering) results in permanent changes to the maternal brain, including the hippocampus. This review outlines the ability of gonadal and stress hormones to modulate multiple aspects of neurogenesis (cell proliferation and cell survival) in both male and female rodents. The function of adult neurogenesis in the hippocampus is linked to spatial memory and depression, and the present review provides early evidence of the functional links between the hormonal modulation of neurogenesis that may contribute to the regulation of cognition and stress.