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In this paper, we present a joint channel estimation and synchronization technique for burst-mode OFDM systems. The technique uses the nonlinear recursive least squares algorithm (NL-RLS) to jointly estimate the channel impulse response (CIR), the carrier frequency offset (CFO), the sampling clock offset (SCO), and the timing offset, and to correct for each of these in the digital domain and without the use of a delay-locked loop (DLL). The need for pilot symbols in the payload data is eliminated by a decision-directed operation mode. The time-domain NL-RLS algorithm needs a small number of parameters to be estimated and can suppress the effect of decision feedback errors. Simulation results confirm its improved performance and relatively low variance.

The Neotropical species of the rarely collected genus Bolitogyrus (Coleoptera: Staphylinidae: Staphylininae: Staphylinini) are revised. The genus exhibits an uncommon, disjunct distribution between the Neotropical and Oriental Regions and is of unknown phylogenetic position within Staphylinini. Morphological evolution remarkable for Staphylinini was discovered within Bolitogyrus, including sexually dimorphic modifications of the pronotum that may be involved in male competition for females. rSEM interactive animations were used to establish morphological species boundaries between two highly variable species and are provided to illustrate diagnostic characters of the genitalia in unconventional views. The genus is redescribed based on the world fauna and twenty-eight Neotropical species are considered valid. Of these, nineteen are described as new to science: Bolitogyrus ashei sp. n.; B. apicofasciatus sp. n.; B. brevistellus sp. n.; B. bufo sp. n.; B. cheungi sp. n.; B. cornutus sp. n.; B. divisus sp. n.; B. falini sp. n.; B. gracilis sp. n.; B. inexspectatus sp. n.; B. longistellus sp. n.; B. marquezi sp. n.; B. newtoni sp. n.; B. pseudotortifolius sp. n.; B. pulchrus sp. n.; B. silex sp. n.; B. thomasi sp. n.; B. tortifolius sp. n.; and B. viridescens sp. n. Bolitogyrus sallei (Kraatz), stat. r. is removed from synonymy with B. buphthalmus (Erichson) and the following new synonyms are proposed: Cyrtothorax cyanescens Sharp, 1884, syn. n. = Quedius buphthalmus Erichson, 1840; C. nevermanni Scheerpeltz, 1974, syn. n. = C. costaricensis Wendeler, 1927. A summary of all available bionomic and distributional data, as well as an illustrated identification key to and diagnoses of all Neotropical species are provided.

The Mental Health Commission of Canada’s (MHCC) strategy calls for promoting the health and wellbeing of all Canadians and to improve mental health outcomes. Each year, one in every five Canadians experiences one or more mental health problems, creating a significant cost to the health system. Mental health is pivotal to holistic health and wellbeing. This paper presents the key findings of a comprehensive literature review of Canadian research on the relationship between settlement experiences and the mental health and well-being of immigrants and refugees. A scoping review was conducted following a framework provided by Arskey and O’Malley (Int J Soc Res Methodol 8:19–32, 2005). Over two decades of relevant literature on immigrants’ health in Canada was searched. These included English language peer-reviewed publications from relevant online databases Medline, Embase, PsycInfo, Healthstar, ERIC and CINAHL between 1990 and 2015. The findings revealed three important ways in which settlement affects the mental health of immigrants and refugees: through acculturation related stressors, economic uncertainty and ethnic discrimination. The recommendations for public health practice and policy are discussed.

Argininosuccinate synthetase catalyzes the transformation of citrulline and aspartate into argininosuccinate and pyrophos­phate using the hydrolysis of ATP to AMP and pyrophos­phate. This enzymatic process constitutes the rate-limiting step in both the urea and arginine–citrulline cycles. Previous studies have investigated the crystal structures of argininosuccinate synthetase from bacterial species. In this work, the first crystal structure of human argininosuccinate synthetase in complex with the substrates citrulline and aspartate is presented. The human enzyme is compared with structures of argininosuccinate synthetase from bacteria. In addition, the structure also provides new insights into the function of the numerous clinical mutations identified in patients with type I citrullinaemia (also known as classic citrullinaemia).

Background: We wished to compare the nuisance parameters of pediatric vs. adult randomized-trials (RCTs) and determine if the latter can be used in sample size computations of the former.Methods: In this meta-epidemiologic empirical evaluation we examined meta-analyses from the Cochrane Database of Systematic-Reviews, with at least one pediatric-RCT and at least one adult-RCT. Within each meta-analysis of binary efficacy-outcomes, we calculated the pooled-control-group event-rate (CER) across separately all pediatric and adult-trials, using random-effect models and subsequently calculated the control-group event-rate risk-ratio (CER-RR) of the pooled-pediatric-CERs vs. adult-CERs. Within each meta-analysis with continuous outcomes we calculated the pooled-control-group effect standard deviation (CE-SD) across separately all pediatric and adult-trials and subsequently calculated the CE-SD-ratio of the pooled-pediatric-CE-SDs vs. adult-CE-SDs. We then calculated across all meta-analyses the pooled-CER-RRs and pooled-CE-SD-ratios (primary endpoints) and the pooled-magnitude of effect-sizes of CER-RRs and CE-SD-ratios using REMs. A ratio < 1 indicates that pediatric trials have smaller nuisance parameters than adult trials.Results: We analyzed 208 meta-analyses (135 for binary-outcomes, 73 for continuous-outcomes). For binary outcomes, pediatric-RCTs had on average 10% smaller CERs than adult-RCTs (summary-CE-RR: 0.90; 95% CI: 0.83, 0.98). For mortality outcomes the summary-CE-RR was 0.48 (95% CIs: 0.31, 0.74). For continuous outcomes, pediatric-RCTs had on average 26% smaller CE-SDs than adult-RCTs (summary-CE-SD-ratio: 0.74).Conclusions: Clinically relevant differences in nuisance parameters between pediatric and adult trials were detected. These differences have implications for design of future studies. Extrapolation of nuisance parameters for sample-sizes calculations from adult-trials to pediatric-trials should be cautiously done.

The authors also acknowledge the support and collaboration of many other colleagues in their respective institutes, research communities and IT Infrastructures, together with the funding received by these from many different sources. These include but are not limited to the following: (i) The Worldwide LHC Computing Grid (WLCG) project is a global collaboration of more than 170 computing centres in 43 countries, linking up national and international grid infrastructures. Funding is acknowledged from many national funding bodies and we acknowledge the support of several operational infrastructures including EGI, OSG and NDGF/NeIC. (ii) EGI acknowledges the funding and support received from the European Commission and the many National Grid Initiatives and other members. EOSC-hub receives funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 777536. (iii) The work leading to these results has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. 730941 (AARC2). (iv) Work on the development of ESGF's identity management system has been supported by The UK Natural Environment Research Council and funding from the European Union's Seventh Framework Programme for research, technological development and demonstration through projects IS-ENES (grant agreement no 228203) and IS-ENES2 (grant agreement no 312979). (v) Ludek Matyska and Michal Prochazka acknowledge funding from the RI ELIXIR CZ project funded by MEYS Czech Republic No. LM2015047. (vi) Scott Koranda acknowledges support provided by the United States National Science Foundation under Grant No. PHY-1700765. (vii) GÉANT Association on behalf of the GN4 Phase 2 project (GN4-2).The research leading to these results has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. 731122(GN4-2). (viii) ELIXIR acknowledges support from Research Infrastructure programme of Horizon 2020 grant No 676559 EXCELERATE. (ix) CORBEL life science cluster acknowledges support from Horizon 2020 research and innovation programme under grant agreement No 654248. (x) Mirjam van Daalen acknowledges that the research leading to this result has been supported by the project CALIPSOplus under the Grant Agreement 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020. (xi) EISCAT is an international association supported by research organisations in China (CRIRP), Finland (SA), Japan (NIPR), Norway (NFR), Sweden (VR), and the United Kingdom (NERC). This white-paper expresses common requirements of Research Communities seeking to leverage Identity Federation for Authentication and Authorisation. Recommendations are made to Stakeholders to guide the future evolution of Federated Identity Management in a direction that better satisfies research use cases. The authors represent research communities, Research Services, Infrastructures, Identity Federations and Interfederations, with a joint motivation to ease collaboration for distributed researchers. The content has been edited collaboratively by the Federated Identity Management for Research (FIM4R) Community, with input sought at conferences and meetings in Europe, Asia and North America.

The former genera Oncocnemis Lederer, Apharetra Grote, Hemistilbia Barnes and Benjamin, Adita Grote, Lepipolys Guenée, Homoncocnemis Hampson, and Homohadena Grote are synonymized under Sympistis Hübner. The following are transferred from Oxycnemis Grote to Sympistis: Sympistis franclemonti (Blanchard), comb. n. [Oxycnemis franclemonti Blanchard] and Sympistis subsimplex (Dyar) comb. n. [Oxycnemis subsimplex Dyar]. Two species are transferred to Unciella gen. n. as Unciella primula (Barnes and McDunnough) comb. n. [Oncocnemis primula Barnes and McDunnough] and Unciella flagrantis (Smith) comb. n. [Oncocnemis flagrantis Smith], which along with Leucocnemis Hampson are transferred to tribe Triocnemidini in the Psaphidinae. Supralathosea Barnes and Benjamin is transferred to Psaphidinae: Psaphidini and Catabena pronuba Barnes and McDunnough is transferred to Supralathosea comb. n.. In addition, Cerapoda Smith syn. n. and Prochloridea Barnes and McDunnough syn. n. (Prochloridea is presently in Hodges “unassociated genera”) are synonymized under Rhizagrotis Smith in the Xyleninae. Copanarta sexpunctata Barnes and McDunnough rev. comb. is transferred from Stylopoda to Copanarta. Oncocnemis simplicia Smith syn. n. is synonymized under Homohadena deserta Smith, Oncocnemis mus Troubridge and Crabo syn. n. under Oncocnemis tenuifascia Smith, and Oncocnemis sala Mustelin syn. n. under Oncocnemis aqualis Grote. The following are elevated to species rank: Sympistis deserticola (McDunnough) stat. n., comb. n. [Oncocnemis riparia deserticola McDunnough], Sympistis pallidior (Barnes) stat. n., comb. n. [Oncocnemis figurata pallidior Barnes] and Sympistis pallida (Barnes) stat. n., comb. n. [Oncocnemis homogena pallida Barnes]. The following 50 species are described as new: Sympistis acheron Troubridge, Sympistis amenthes Troubridge, Sympistis amun Troubridge, Sympistis anubis Troubridge, Sympistis anweileri Troubridge and Lafontaine, Sympistis apep Troubridge, Sympistis apis Troubridge, Sympistis babi Troubridge, Sympistis baloghi Troubridge, Sympistis bes Troubridge, Sympistis buchis Troubridge, Sympistis buto Troubridge, Sympistis cherti Troubridge, Sympistis chons Troubridge, Sympistis cleopatra Troubridge, Sympistis cocytus Troubridge, Sympistis collaris Troubridge, Sympistis dischorda Troubridge, Sympistis disfigurata Troubridge, Sympistis doris Dimock and Troubridge, Sympistis hapi Troubridge, Sympistis hathor Troubridge, Sympistis horus Troubridge, Sympistis incubus Troubridge, Sympistis insanina Troubridge, Sympistis isis Troubridge, Sympistis jenniferae Troubridge, Sympistis jocelynae Troubridge, Sympistis khem Troubridge, Sympistis khepri Troubridge, Sympistis knudsoni Troubridge, Sympistis lachrymosa Troubridge, Sympistis min Troubridge, Sympistis mut Troubridge, Sympistis nenun Troubridge, Sympistis opleri Troubridge, Sympistis osiris Troubridge, Sympistis pachet Troubridge, Sympistis ptah Troubridge, Sympistis ra Troubridge, Sympistis richersi Troubridge, Sympistis sakhmet Troubridge, Sympistis septu Troubridge, Sympistis sesmu Troubridge, Sympistis seth Troubridge, Sympistis shait Troubridge, Sympistis shirleyae Troubridge, Sympistis sobek Troubridge, Sympistis sokar Troubridge, and Sympistis serapis Troubridge. Color illustrations are provided for adults of all nearctic Sympistis species. Alphabetical and phylogenetic checklists of North American Oncocnemidinae are also provided, including species formerly placed there, but here transferred to other subfamilies.

Ample evidence supports the use of Virtual Reality (VR) for anxiety disorders. Nonetheless, currently there is no evidence about moderators or potential negative effects of VR treatment strategies. An Individual Patient Data (IPD) approach was employed with 15 retrieved datasets. The current study sample was composed of 810 patients. Randomized control trials (RCTs) for each primary outcome measure were performed, in addition to moderator analyses of the socio-demographic variables. Deterioration rates were 14 patients (4.0%) in VR, 8 (2.8%) in active control conditions, and 27 (15%) in the WL condition. With regard to receiving treatment, patients in a waiting list control condition had greater odds of deteriorating than in the two active conditions, odds ratios (ORs) 4.87, 95% confidence interval (CI) [0.05, 0.67]. In the case of the socio-demographic variables, none of them were associated with higher or lower odds of deterioration, with the exception of marital status in the WL condition; married people presented a significantly lower probability of deterioration, OR 0.19, 95% CI [0.05, 0.67]. Finally, when comparing pooled effects of VR versus all control conditions, the OR was 0.61 (95% CI 0.31–1.23) in favor of VR, although this result was not statistically significant. This study provides evidence about the deterioration rates of a therapeutic VR approach, showing that the number of deteriorated patients coincides with other therapeutic approaches, and that deterioration is less likely to occur, compared to patients in WL control groups.

IN a recent number of the Philosophical Magazine (November, 1904), I have shown that radium, after passing through four rapid changes, finally gives rise to two slow transformation products, which, on the scheme of changes there outlined, were called radium D and radium E.

Resulting from prenatal exposure to alcohol, Fetal Alcohol Spectrum Disorder (FASD) is characterized by deficits in adaptive and cognitive functioning. This disorder is typically accompanied by co-occurring disorders and conditions (e.g., mood, anxiety, psychosis, and substance use disorders). This complicated presentation of diverse symptoms makes the process of screening, assessing, and diagnosing FASD very difficult, limiting the likelihood that clients receive the treatment and services that they need. Although mental health care providers have an opportunity to intervene on behalf of clients with FASD, professionals may not be very familiar or comfortable with this complicated and life-altering disorder. The present study explores the familiarity of 79 mental health outpatient treatment professionals&rsquo personal knowledge and training about FASD. Findings suggest that the majority of respondents had received at least some FASD training, understood the basic symptoms of FASD, and were realistic about FASD&rsquo s impact on treatment.