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Figure S1. The genotype of NOD1/2 DKO mice. Genomic DNA from mice was amplified by PCR with specific primers to detect the disrupted sequences on a 1% agarose gel with a 100Â bp marker. First 5 bands are the KO mice and the last bands are the WT mice in A and B. NÂ =â 5/3 per group. (TIFF 12868 kb)

Table S3. Cis acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. (XLS 31 kb)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures. Related Article: A.V.Chuchuryukin, P.A.Chase, A.M.Mills, M.Lutz, A.L.Spek, G.P.M.van Klink, G.van Koten|2006|Inorg.Chem.|45|2045|doi:10.1021/ic051773x

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures. Related Article: A.V.Chuchuryukin, P.A.Chase, A.M.Mills, M.Lutz, A.L.Spek, G.P.M.van Klink, G.van Koten|2006|Inorg.Chem.|45|2045|doi:10.1021/ic051773x

Table S7. CpG sites showing significant (FDR pâ

Table S9. Literature search results for smoking EWAS. (XLS 9 kb)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures. Related Article: A.V.Chuchuryukin, P.A.Chase, A.M.Mills, M.Lutz, A.L.Spek, G.P.M.van Klink, G.van Koten|2006|Inorg.Chem.|45|2045|doi:10.1021/ic051773x

Table S5. Mediation analysis omnibus P values for the 19 meQTLs associated with serum cotinine levels. (XLS 33 kb)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures. Related Article: A.V.Chuchuryukin, P.A.Chase, A.M.Mills, M.Lutz, A.L.Spek, G.P.M.van Klink, G.van Koten|2006|Inorg.Chem.|45|2045|doi:10.1021/ic051773x

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures. Related Article: A.V.Chuchuryukin, P.A.Chase, A.M.Mills, M.Lutz, A.L.Spek, G.P.M.van Klink, G.van Koten|2006|Inorg.Chem.|45|2045|doi:10.1021/ic051773x