325 Research products, page 1 of 33
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- Other research product . 2023Open Access English
Introduction Food allergy affects approximately 7.0% of children worldwide. Children spend most of their waking hours at school, yet, teachers, who have the majority of contact with children during all school day, have variable food allergy-related knowledge. Objective We aimed to identify how Winnipeg-based elementary school teachers manage food allergic reactions in their classrooms and schools. Methods Winnipeg-based public and private school teachers who taught Kindergarten to Grade 6 were recruited via social media and word-of-mouth, and were interviewed virtually consent. Interviews were recorded and transcribed verbatim. The study followed a pragmatic framework. Data were analysed via thematic analysis. Member checking was done to enhance study rigour. Results We interviewed 16 teachers, who taught primarily public school and between Kindergarten Grade 3. The manuscript presents four identified themes. Theme 1 (“Each classroom is a case-by-case basis”) describes the minimal standardization and inconsistent policies and education between and within schools. Theme 2 (Food allergy-related knowledge, experience and supports shape teachers’ confidence) reflected teachers’ variable confidence/perceived food allergy knowledge. Theme 3 (Food allergy could be a more prominent conversation for teachers to “debunk the myths”) captured the lack of standardized food allergy education for teachers. Theme 4 (Communication between all parties is essential) described how teachers’ reliance on school staff, families and students to effectively communicate. The published paper presents two identified themes. Theme 1 (COVID-19 restrictions made mealtimes more manageable) depicted how pandemic-related restrictions, such as enhanced cleaning, handwashing, and emphasis on no food sharing, were deemed positively influencing food allergy management. Theme 2 (Food allergy management was indirectly adapted to fit changing COVID-19 restrictions) captured how food allergy management had to be adapted to pandemic restrictions. Teachers also had less nursing supports and virtual training. Conclusions Teachers’ food allergy management was informed by their knowledge and lived experience, guided by school policies, and students’ needs. Continuation of pandemic-related restrictions may enhance food allergy management in the classroom. Teachers unanimously wanted further food allergy education and training, and resources to improve communication gaps and language barriers. More training throughout the school year and multimedia resources may be beneficial.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . Other ORP type . 2022
Un des principaux secteurs frappés par la COVID-19, l'industrie touristique du Québec a fait face à une crise sans précédent. L'absence des croisières internationales pour l'année 2020 et 2021 a particulièrement affecté les villes portuaires du Saint-Laurent et les nombreux acteurs qui bénéficiaient des retombées économiques de cette industrie. Les grossistes en voyage et les organisations issues de secteurs de l'industrie touristique à destination (ex. restauration, hébergement) ne pouvaient plus offrir des prestations aux croisiéristes. La période d'arrêt occasionné par la COVID-19 représente une opportunité de réflexion sur les enjeux de ce secteur touristique avant une reprise des activités en 2022. Ces enjeux se manifestent sur le plan social (ex. qualité de vie des communautés d'accueil), environnemental (ex. influence sur la faune et la flore du Saint-Laurent) et économique (ex. coûts nécessaires pour le développement de cette industrie). L'objectif général de cette recherche consiste à éclairer les acteurs touristiques de la région de Québec et du Saint-Laurent afin de leur permettre de développer un modèle d'affaires facilitant la relance et la durabilité du tourisme de croisière post-COVID-19. Pour y parvenir, 24 personnes, principalement issues d'organisations des croisières internationales du Saint-Laurent, ont participé à des entretiens individuels. Les données de ces entretiens ont été traitées à l'aide d'une démarche de nature qualitative. Les résultats de cette recherche nous ont permis d'identifier les principaux enjeux sous un angle pré et post-pandémique. La grande majorité des représentants, 75 %, affirme que les stratégies de développement des croisières demeurent bénéfiques pour le Québec. Cependant, 83% des représentants soulignent que ces stratégies contribuent ou peuvent contribuer à un phénomène de surfréquentation ou de surtourisme dans certaines zones touristiques du Québec. Les résultats permettent également d'identifier le manque de connaissances des représentants envers les composantes de l'écosystème de l'industrie des croisières internationales du Saint-Laurent. La présentation des résultats sera accompagnée de diagrammes, tableaux ou nuage de mots-clés afin d'illustrer les principaux résultats.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . Other ORP type . 2021Open Access EnglishAuthors:Romund, Grace; Fuhr, Justin; Speare, Marie; Albrecht, Vickie; Babb, Maureen; Schultz, Ryan;Romund, Grace; Fuhr, Justin; Speare, Marie; Albrecht, Vickie; Babb, Maureen; Schultz, Ryan;
handle: 1993/35976
Publisher: American Libraries Association Conference (ALA ’21)Country: CanadaThe University of Manitoba’s science librarians developed a three-credit, second-year course entitled “Information Skills for the Sciences” that was delivered for the first time in the fall of 2020. The culminating project of the course was a scientific poster session where students shared their research project as a poster presentation with their instructors and classmates. Due to the COVID-19 pandemic, the course was moved to online synchronous delivery and all assignments needed to be adapted for the online format. We designed a virtual poster session simulating an in-person event, hosting the poster session on Zoom for a class of twenty students using breakout rooms to separate presentations. Our poster details the methods used to deliver an online in-class poster session in an undergraduate setting with visualizations to illustrate the experience. Despite the conditions of remote learning, the poster presentation session allowed students to engage meaningfully with the research of their classmates demonstrating that an exciting end-of-semester event like an in-person poster session was possible in an online environment. We discuss the challenges we encountered creating the poster session as well as our reflections on what worked and what might be improved in the future.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . Other ORP type . 2020Open Access English
Despite ongoing relationship building efforts at the community level, Indigenous and immigrant and refugee newcomer communities in Canada continue to experience a fractured relationship characterized by misperceptions, misunderstandings and tension. One of the predominant reasons for this ongoing fractured relationship is the lack of community-driven, decolonial information that each community receives about the other. This project sought to respond to this reality, by exploring the experience of an online relationship building Talking Circle and video-making process, where Indigenous and newcomer youth reflected on their identities as newcomer or Indigenous peoples and the possibilities for transformed relationships between both communities. The video that was created then went on to be shared with Indigenous and newcomer serving organizations within Winnipeg and was posted free online, becoming a potential community-driven, decolonial relationship building resource for community members to access. This project was guided by an Indigenous research paradigm, as well as the visiting way, storytelling and arts-based methodologies. Overall, this project found an imbalance in perceptions between both communities, alongside relationship building possibilities within increasing opportunities for community-driven, decolonial information to be transferred, shared minority experiences and cultural strengths, and the need for both formal and informal relationship building opportunities. Several key implications for social work practice are discussed and recommendations for bridging relations between Indigenous and newcomer communities are proposed.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 2022Open Access EnglishAuthors:Justin Draper;Justin Draper;Country: Canada
In January of 2022, the self entitled #UnitedWeRoll convoy arrived in Ottawa and other locations around Canada to demonstrate against COVID-19 health measures and protest governments in Canada. While the group originated online, the in-person demonstrators commenced a month-long occupation that impacted international trade, community safety and brought the still raging conversation about COVID-19 even more to the forefront of Canadian society. With online communities being an influential venue for political discussion, it is important to understand the role of social media platforms and how social media content creators contribute to social and political movements on and offline. In this research, I analyze social media content produced by members of the far right on TikTok using the 2022 Canadian anti COVID-19 mandate demonstrations as a case study in order to gain insight into how far right movements in Canada grow and recruit new members to their networks.
- Other research product . 2020Open Access EnglishAuthors:University Advancement & Communications, University of Regina;University Advancement & Communications, University of Regina;
handle: 10294/14830
Publisher: University Advancement & Communications, University of ReginaCountry: CanadaStrength, resilience, adaptability, and compassion - these are the building blocks of the Regina COVID-19 Volunteer Community Response Team, a community support network initiated by Dr. JoLee Sasakamoose, Associate Professor in Educational Psychology and Counselling at the University of Regina. Since a state of emergency was announced by the Government of Saskatchewan in March 2020, the Regina COVID Response team of five core members and numerous volunteers has been working day and night to support Elders and other vulnerable Indigenous people in Regina, who do not have a network of family or caregivers. Staff no
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 2021Open Access EnglishAuthors:Arezoo Haratian; Hadi Fazelinia; Zeinab Maleki; Pouria Ramazi; Hao Wang; Mark A. Lewis; Russell Greiner; David Wishart;Arezoo Haratian; Hadi Fazelinia; Zeinab Maleki; Pouria Ramazi; Hao Wang; Mark A. Lewis; Russell Greiner; David Wishart;Country: Canada
This dataset provides information related to the outbreak of COVID-19 disease in the United States, including data from each of 3142 US counties from the beginning of the outbreak (January 2020) until June 2021. This data is collected from many public online databases and includes the daily number of COVID-19 confirmed cases and deaths, as well as 46 features that may be relevant to the pandemic dynamics: demographic, geographic, climatic, traffic, public-health, social-distancing-policy adherence, and political characteristics of each county. We anticipate many researchers will use this dataset to train models that can predict the spread of COVID-19 and to identify the key driving factors.
- Other research product . Other ORP typeOpen Access English
The devastating COVID-19 pandemic caused by the coronavirus SARS-CoV-2 continues to be prolonged by the ability of the virus to evolve into more transmissible and vaccine-resistant variants of concern (VOC). These fast-evolving VOC demonstrate the need for broad-acting antivirals against coronaviruses. As with several other human-infecting viruses, SARS-CoV-2 initiates attachment to host cells by binding to complex cell-surface carbohydrates known as glycans. These glycans are used by the virus to recognize and concentrate virions on the host cell surface and facilitate binding to less abundant entry receptors, like ACE2 for SARS-CoV-2. Due to most viruses using glycans to initiate infection, we therefore hypothesize that glycans are a worthy target for broad-acting antivirals. While monovalent carbohydrate-protein interactions are weak and have a low affinity, virions exploit multivalent interactions and the attachment of viruses to the cell is relatively strong. Therefore, one strategy in building a broad-based antiviral is to develop multivalent prophylactic antivirals that blocks this initial attachment of SARS-CoV-2 to glycans in the upper respiratory tract by targeting these carbohydrate-protein interactions. This thesis will describe an approach we are developing to synthesize multivalent carbohydrate-based antivirals for SARS-CoV-2 by targeting initial glycan-mediated interactions involved in viral attachment. Four preliminary targets for SARS-CoV-2 have been identified: mannose, galactose, N-acetylneuraminic acid, and gallic acid. These targets are functionalized with linkers bearing an azide functionality to facilitate conjugation to multivalent dendrimers scaffolds comprised of 3-24 alkyne moieties. The azide and alkyne functionalities allow for quick conjugation of the glycan mimetic derivatives through copper-catalyzed azide-alkyne cycloaddition (CuAAC), creating multivalent glycan-based dendrimers. The efficacy of these dendrimers as inhibitors will be tested using a SARS-CoV-2 viral entry assay using A549 epithelial cells with and without overexpression of the ACE2 receptor protein and lentivirus pseudo-typed with spike protein, with viral entry being measured by luciferase reporter activity.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 2021Open AccessAuthors:Waechtler, Heidi;Waechtler, Heidi;Country: Canada
This report documents my experience of teaching PUB 800 – Text and Context: Publishing in Contemporary Culture at SFU Publishing in the Fall 2020 semester, which was both my first time teaching this course and the first time it had been delivered remotely, owing to the COVID-19 pandemic. It details the work of designing a publishing theory seminar as a non-academic, industry professional, and examines how a course that originated as a primer in Canadian publishing policy has evolved into a seminar course that more broadly interrogates the structure, state, and culture of contemporary publishing. The report reflects on the challenges of structuring the course to adequately cover the necessary material in twelve weeks, and on the limitations of using Canadian book publishing as the course’s primary case study. It also looks at the adaptations made to the course structure and delivery in light of the pandemic.
- Other research product . Other ORP typeClosed Access English
Background: Viral respiratory infections represent a significant burden of illness with high morbidity and mortality, which has been further magnified in recent years by the emergence of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Viruses including SARS-CoV-2, Influenza A Virus (Flu-A), and Respiratory Syncytial Virus (RSV) utilize the nasopharynx for viral entry, replication and infection. The nasopharynx epithelial cell mucous membrane harbors a diverse community of bacteria, called the nasal microbiota (NM). Flu-A can modulate changes in the NM community and lead to pathobiont enrichment. Therefore, here we aim to investigate the NM of individuals with SARS-CoV-2, Flu-A and RSV infection, and identify correlates between the NM community and viral load (VL) and SARS-CoV-2 variants of concern (VOC). Methods: Nasopharyngeal (NP) swabs were collected and tested for SARS-CoV-2, Flu-A, and RSV by validated real-time PCR (RT-PCR) assays. RNA extraction was performed using a Maxwell automatic nucleic acid extractor followed by 16S rRNA Illumina Next Generation Sequencing (NGS) library sample preparation for NGS on a MiSeq Sequencer. QIIME II, Microbiome Analyst and PRISM 9.0.0 were used for data analysis. Results: NP swabs from 118 SARS-CoV-2, 40 Flu-A, 26 RSV positive and 45 negative controls (NC) were included. An increase in alpha and beta bacterial diversity (p<0.001) was observed in the NM of SARS-CoV-2 patients and an enrichment in Streptococcus and Staphylococcus species and depletion of Bifidobacterium and Moraxella species compared to NC’s (p<0.001). Compared to Flu-A and RSV patients, SARS-CoV-2 positives showed enrichment in Streptococcus, and depletion in Haemophilus species (p<0.002). 73/118 SARS-CoV-2 specimens were further sequenced to identify VOC lineage and stratified by VL. No significance in bacterial richness, diversity, or abundance correlated to VL. Only a significant difference in beta diversity was observed between the alpha/delta and omicron cohorts (p<0.001). Conclusions: This study demonstrates that the NM community is different in individuals with respiratory illness and distinct between SARS-CoV-2, Flu-A and RSV infected individuals. This study also demonstrated that NM beta diversity was different between individuals with different SARS-CoV-2 lineages, suggesting virus-NM interplay that may be important in explaining differences in transmission potentials and pathogenesis between SARS-CoV-2 VOCs.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.
325 Research products, page 1 of 33
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- Other research product . 2023Open Access English
Introduction Food allergy affects approximately 7.0% of children worldwide. Children spend most of their waking hours at school, yet, teachers, who have the majority of contact with children during all school day, have variable food allergy-related knowledge. Objective We aimed to identify how Winnipeg-based elementary school teachers manage food allergic reactions in their classrooms and schools. Methods Winnipeg-based public and private school teachers who taught Kindergarten to Grade 6 were recruited via social media and word-of-mouth, and were interviewed virtually consent. Interviews were recorded and transcribed verbatim. The study followed a pragmatic framework. Data were analysed via thematic analysis. Member checking was done to enhance study rigour. Results We interviewed 16 teachers, who taught primarily public school and between Kindergarten Grade 3. The manuscript presents four identified themes. Theme 1 (“Each classroom is a case-by-case basis”) describes the minimal standardization and inconsistent policies and education between and within schools. Theme 2 (Food allergy-related knowledge, experience and supports shape teachers’ confidence) reflected teachers’ variable confidence/perceived food allergy knowledge. Theme 3 (Food allergy could be a more prominent conversation for teachers to “debunk the myths”) captured the lack of standardized food allergy education for teachers. Theme 4 (Communication between all parties is essential) described how teachers’ reliance on school staff, families and students to effectively communicate. The published paper presents two identified themes. Theme 1 (COVID-19 restrictions made mealtimes more manageable) depicted how pandemic-related restrictions, such as enhanced cleaning, handwashing, and emphasis on no food sharing, were deemed positively influencing food allergy management. Theme 2 (Food allergy management was indirectly adapted to fit changing COVID-19 restrictions) captured how food allergy management had to be adapted to pandemic restrictions. Teachers also had less nursing supports and virtual training. Conclusions Teachers’ food allergy management was informed by their knowledge and lived experience, guided by school policies, and students’ needs. Continuation of pandemic-related restrictions may enhance food allergy management in the classroom. Teachers unanimously wanted further food allergy education and training, and resources to improve communication gaps and language barriers. More training throughout the school year and multimedia resources may be beneficial.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . Other ORP type . 2022
Un des principaux secteurs frappés par la COVID-19, l'industrie touristique du Québec a fait face à une crise sans précédent. L'absence des croisières internationales pour l'année 2020 et 2021 a particulièrement affecté les villes portuaires du Saint-Laurent et les nombreux acteurs qui bénéficiaient des retombées économiques de cette industrie. Les grossistes en voyage et les organisations issues de secteurs de l'industrie touristique à destination (ex. restauration, hébergement) ne pouvaient plus offrir des prestations aux croisiéristes. La période d'arrêt occasionné par la COVID-19 représente une opportunité de réflexion sur les enjeux de ce secteur touristique avant une reprise des activités en 2022. Ces enjeux se manifestent sur le plan social (ex. qualité de vie des communautés d'accueil), environnemental (ex. influence sur la faune et la flore du Saint-Laurent) et économique (ex. coûts nécessaires pour le développement de cette industrie). L'objectif général de cette recherche consiste à éclairer les acteurs touristiques de la région de Québec et du Saint-Laurent afin de leur permettre de développer un modèle d'affaires facilitant la relance et la durabilité du tourisme de croisière post-COVID-19. Pour y parvenir, 24 personnes, principalement issues d'organisations des croisières internationales du Saint-Laurent, ont participé à des entretiens individuels. Les données de ces entretiens ont été traitées à l'aide d'une démarche de nature qualitative. Les résultats de cette recherche nous ont permis d'identifier les principaux enjeux sous un angle pré et post-pandémique. La grande majorité des représentants, 75 %, affirme que les stratégies de développement des croisières demeurent bénéfiques pour le Québec. Cependant, 83% des représentants soulignent que ces stratégies contribuent ou peuvent contribuer à un phénomène de surfréquentation ou de surtourisme dans certaines zones touristiques du Québec. Les résultats permettent également d'identifier le manque de connaissances des représentants envers les composantes de l'écosystème de l'industrie des croisières internationales du Saint-Laurent. La présentation des résultats sera accompagnée de diagrammes, tableaux ou nuage de mots-clés afin d'illustrer les principaux résultats.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . Other ORP type . 2021Open Access EnglishAuthors:Romund, Grace; Fuhr, Justin; Speare, Marie; Albrecht, Vickie; Babb, Maureen; Schultz, Ryan;Romund, Grace; Fuhr, Justin; Speare, Marie; Albrecht, Vickie; Babb, Maureen; Schultz, Ryan;
handle: 1993/35976
Publisher: American Libraries Association Conference (ALA ’21)Country: CanadaThe University of Manitoba’s science librarians developed a three-credit, second-year course entitled “Information Skills for the Sciences” that was delivered for the first time in the fall of 2020. The culminating project of the course was a scientific poster session where students shared their research project as a poster presentation with their instructors and classmates. Due to the COVID-19 pandemic, the course was moved to online synchronous delivery and all assignments needed to be adapted for the online format. We designed a virtual poster session simulating an in-person event, hosting the poster session on Zoom for a class of twenty students using breakout rooms to separate presentations. Our poster details the methods used to deliver an online in-class poster session in an undergraduate setting with visualizations to illustrate the experience. Despite the conditions of remote learning, the poster presentation session allowed students to engage meaningfully with the research of their classmates demonstrating that an exciting end-of-semester event like an in-person poster session was possible in an online environment. We discuss the challenges we encountered creating the poster session as well as our reflections on what worked and what might be improved in the future.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . Other ORP type . 2020Open Access English
Despite ongoing relationship building efforts at the community level, Indigenous and immigrant and refugee newcomer communities in Canada continue to experience a fractured relationship characterized by misperceptions, misunderstandings and tension. One of the predominant reasons for this ongoing fractured relationship is the lack of community-driven, decolonial information that each community receives about the other. This project sought to respond to this reality, by exploring the experience of an online relationship building Talking Circle and video-making process, where Indigenous and newcomer youth reflected on their identities as newcomer or Indigenous peoples and the possibilities for transformed relationships between both communities. The video that was created then went on to be shared with Indigenous and newcomer serving organizations within Winnipeg and was posted free online, becoming a potential community-driven, decolonial relationship building resource for community members to access. This project was guided by an Indigenous research paradigm, as well as the visiting way, storytelling and arts-based methodologies. Overall, this project found an imbalance in perceptions between both communities, alongside relationship building possibilities within increasing opportunities for community-driven, decolonial information to be transferred, shared minority experiences and cultural strengths, and the need for both formal and informal relationship building opportunities. Several key implications for social work practice are discussed and recommendations for bridging relations between Indigenous and newcomer communities are proposed.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 2022Open Access EnglishAuthors:Justin Draper;Justin Draper;Country: Canada
In January of 2022, the self entitled #UnitedWeRoll convoy arrived in Ottawa and other locations around Canada to demonstrate against COVID-19 health measures and protest governments in Canada. While the group originated online, the in-person demonstrators commenced a month-long occupation that impacted international trade, community safety and brought the still raging conversation about COVID-19 even more to the forefront of Canadian society. With online communities being an influential venue for political discussion, it is important to understand the role of social media platforms and how social media content creators contribute to social and political movements on and offline. In this research, I analyze social media content produced by members of the far right on TikTok using the 2022 Canadian anti COVID-19 mandate demonstrations as a case study in order to gain insight into how far right movements in Canada grow and recruit new members to their networks.
- Other research product . 2020Open Access EnglishAuthors:University Advancement & Communications, University of Regina;University Advancement & Communications, University of Regina;
handle: 10294/14830
Publisher: University Advancement & Communications, University of ReginaCountry: CanadaStrength, resilience, adaptability, and compassion - these are the building blocks of the Regina COVID-19 Volunteer Community Response Team, a community support network initiated by Dr. JoLee Sasakamoose, Associate Professor in Educational Psychology and Counselling at the University of Regina. Since a state of emergency was announced by the Government of Saskatchewan in March 2020, the Regina COVID Response team of five core members and numerous volunteers has been working day and night to support Elders and other vulnerable Indigenous people in Regina, who do not have a network of family or caregivers. Staff no
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 2021Open Access EnglishAuthors:Arezoo Haratian; Hadi Fazelinia; Zeinab Maleki; Pouria Ramazi; Hao Wang; Mark A. Lewis; Russell Greiner; David Wishart;Arezoo Haratian; Hadi Fazelinia; Zeinab Maleki; Pouria Ramazi; Hao Wang; Mark A. Lewis; Russell Greiner; David Wishart;Country: Canada
This dataset provides information related to the outbreak of COVID-19 disease in the United States, including data from each of 3142 US counties from the beginning of the outbreak (January 2020) until June 2021. This data is collected from many public online databases and includes the daily number of COVID-19 confirmed cases and deaths, as well as 46 features that may be relevant to the pandemic dynamics: demographic, geographic, climatic, traffic, public-health, social-distancing-policy adherence, and political characteristics of each county. We anticipate many researchers will use this dataset to train models that can predict the spread of COVID-19 and to identify the key driving factors.
- Other research product . Other ORP typeOpen Access English
The devastating COVID-19 pandemic caused by the coronavirus SARS-CoV-2 continues to be prolonged by the ability of the virus to evolve into more transmissible and vaccine-resistant variants of concern (VOC). These fast-evolving VOC demonstrate the need for broad-acting antivirals against coronaviruses. As with several other human-infecting viruses, SARS-CoV-2 initiates attachment to host cells by binding to complex cell-surface carbohydrates known as glycans. These glycans are used by the virus to recognize and concentrate virions on the host cell surface and facilitate binding to less abundant entry receptors, like ACE2 for SARS-CoV-2. Due to most viruses using glycans to initiate infection, we therefore hypothesize that glycans are a worthy target for broad-acting antivirals. While monovalent carbohydrate-protein interactions are weak and have a low affinity, virions exploit multivalent interactions and the attachment of viruses to the cell is relatively strong. Therefore, one strategy in building a broad-based antiviral is to develop multivalent prophylactic antivirals that blocks this initial attachment of SARS-CoV-2 to glycans in the upper respiratory tract by targeting these carbohydrate-protein interactions. This thesis will describe an approach we are developing to synthesize multivalent carbohydrate-based antivirals for SARS-CoV-2 by targeting initial glycan-mediated interactions involved in viral attachment. Four preliminary targets for SARS-CoV-2 have been identified: mannose, galactose, N-acetylneuraminic acid, and gallic acid. These targets are functionalized with linkers bearing an azide functionality to facilitate conjugation to multivalent dendrimers scaffolds comprised of 3-24 alkyne moieties. The azide and alkyne functionalities allow for quick conjugation of the glycan mimetic derivatives through copper-catalyzed azide-alkyne cycloaddition (CuAAC), creating multivalent glycan-based dendrimers. The efficacy of these dendrimers as inhibitors will be tested using a SARS-CoV-2 viral entry assay using A549 epithelial cells with and without overexpression of the ACE2 receptor protein and lentivirus pseudo-typed with spike protein, with viral entry being measured by luciferase reporter activity.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 2021Open AccessAuthors:Waechtler, Heidi;Waechtler, Heidi;Country: Canada
This report documents my experience of teaching PUB 800 – Text and Context: Publishing in Contemporary Culture at SFU Publishing in the Fall 2020 semester, which was both my first time teaching this course and the first time it had been delivered remotely, owing to the COVID-19 pandemic. It details the work of designing a publishing theory seminar as a non-academic, industry professional, and examines how a course that originated as a primer in Canadian publishing policy has evolved into a seminar course that more broadly interrogates the structure, state, and culture of contemporary publishing. The report reflects on the challenges of structuring the course to adequately cover the necessary material in twelve weeks, and on the limitations of using Canadian book publishing as the course’s primary case study. It also looks at the adaptations made to the course structure and delivery in light of the pandemic.
- Other research product . Other ORP typeClosed Access English
Background: Viral respiratory infections represent a significant burden of illness with high morbidity and mortality, which has been further magnified in recent years by the emergence of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Viruses including SARS-CoV-2, Influenza A Virus (Flu-A), and Respiratory Syncytial Virus (RSV) utilize the nasopharynx for viral entry, replication and infection. The nasopharynx epithelial cell mucous membrane harbors a diverse community of bacteria, called the nasal microbiota (NM). Flu-A can modulate changes in the NM community and lead to pathobiont enrichment. Therefore, here we aim to investigate the NM of individuals with SARS-CoV-2, Flu-A and RSV infection, and identify correlates between the NM community and viral load (VL) and SARS-CoV-2 variants of concern (VOC). Methods: Nasopharyngeal (NP) swabs were collected and tested for SARS-CoV-2, Flu-A, and RSV by validated real-time PCR (RT-PCR) assays. RNA extraction was performed using a Maxwell automatic nucleic acid extractor followed by 16S rRNA Illumina Next Generation Sequencing (NGS) library sample preparation for NGS on a MiSeq Sequencer. QIIME II, Microbiome Analyst and PRISM 9.0.0 were used for data analysis. Results: NP swabs from 118 SARS-CoV-2, 40 Flu-A, 26 RSV positive and 45 negative controls (NC) were included. An increase in alpha and beta bacterial diversity (p<0.001) was observed in the NM of SARS-CoV-2 patients and an enrichment in Streptococcus and Staphylococcus species and depletion of Bifidobacterium and Moraxella species compared to NC’s (p<0.001). Compared to Flu-A and RSV patients, SARS-CoV-2 positives showed enrichment in Streptococcus, and depletion in Haemophilus species (p<0.002). 73/118 SARS-CoV-2 specimens were further sequenced to identify VOC lineage and stratified by VL. No significance in bacterial richness, diversity, or abundance correlated to VL. Only a significant difference in beta diversity was observed between the alpha/delta and omicron cohorts (p<0.001). Conclusions: This study demonstrates that the NM community is different in individuals with respiratory illness and distinct between SARS-CoV-2, Flu-A and RSV infected individuals. This study also demonstrated that NM beta diversity was different between individuals with different SARS-CoV-2 lineages, suggesting virus-NM interplay that may be important in explaining differences in transmission potentials and pathogenesis between SARS-CoV-2 VOCs.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.