research data . Dataset . 2018

Cdc48/VCP promotes chromosome morphogenesis by releasing condensin from self-entrapment in chromatin

Thattikota, Y;
Open Access
  • Published: 02 Mar 2018
  • Publisher: Mendeley
  • Country: Netherlands
Abstract
The morphological transformation of amorphous chromatin into distinct chromosomes is a hallmark of mitosis. To achieve this, chromatin must be compacted and remodeled by a ring-shaped enzyme complex known as condensin. However, the mechanistic basis underpinning condensin’s role in chromosome remodeling has remained elusive. Here we show that condensin has a strong tendency to trap itself in its own reaction product during chromatin compaction and yet is capable of interacting with chromatin in a highly dynamic manner in vivo. To resolve this apparent paradox, we identified specific chromatin remodelers and AAA-class ATPases that act in a coordinated manner to r...
Persistent Identifiers
Subjects
Medical Subject Headings: macromolecular substances
free text keywords: Chromosome Organization, Interdisciplinary sciences
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
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