research data . Dataset . 2017 . Embargo end date: 18 Dec 2017

CELL-D-16-01418R3_Widenmaier et al.

Widenmaier, Scott;
Embargo
  • Published: 01 Jan 2017
  • Publisher: Mendeley
Abstract
Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging properties. While the mechanisms by which ER defends against cholesterol insufficiency are well described, it remains unclear how ER senses and effectively defends against cholesterol excess. Here, we identify the ER-bound transcription factor nuclear factor erythroid 2 related factor-1, Nrf1/Nfe2L1, as a critical mediator of this process. We show Nrf1 directly binds to and specifically senses cholesterol in the ER through a defined domain, and that cholesterol regulates Nrf1 turnover, processing, localization, and activity. In Nrf1 def...
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Biological Sciences, Cholesterol, Fatty Liver
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
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Mendeley Data
Dataset . 2017
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Mendeley Data
Dataset . 2017
Embargo
Mendeley Data
Dataset . 2017
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