research data . Dataset . 2018

Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks

Drissi, Romain; Chauvin, Anaïs; McKenna, Alyson; Lévesque, Dominique; Blais-Brochu, Simon; Jean, Dominique; François-Michel Boisvert;
Open Access
  • Published: 01 Jan 2018
  • Publisher: Taylor & Francis
Abstract
DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is replicated only once. The minichromosome maintenance proteins, MCM2 to MCM7, form a heteromeric DNA helicase required for both the initiation and elongation of DNA replication. Although only two DNA helicase activities are necessary to establish a bidirectional replication fork from each replication origin, a large excess of MCM complexes is amassed and distributed along the chromatin. The function of the additional MCM complexes is not well understood, as most are displaced from the DNA during the S-phase, apparently without playin...
Funded by
NWO| Hyperthermia treatment planning for head and neck cancer: improving patient models using advanced MRI characteristics.
Project
  • Funder: Netherlands Organisation for Scientific Research (NWO) (NWO)
  • Project Code: 2300157579
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
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Open Access
figshare
Dataset . 2018
Provider: Datacite
Open Access
figshare
Dataset . 2018
Provider: Datacite
Open Access
figshare
Dataset . 2018
Provider: Datacite
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