STFC: Samuel D. Walton: 2062533 Near-Earth space holds two major surprises that scientists are yet to understand, one of which is the Van Allen Radiation Belts. As an astrophysical object, the Earth's magnetosphere would seem to be a rather small and insignificant item ...

G protein-coupled receptors (GPCRs) represent the largest family of cell surface proteins. Agonist binding to GPCRs activates G proteins regulating many cellular effectors. Classically, G protein activation occurs at the plasma membrane and is rapidly terminated by β-ar...

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxida...

Accounting for high genetic diversity in ecologically-important traits is a fundamental problem in evolutionary biology. Individuals vary enormously at the genetic level, even within local populations, and we do not understand why. Recent work implicates an advantage to...

This proposal aims to maintain and expand the research impact of an internationally-leading team working on advanced structural materials for applications in nuclear fission and fusion reactors. The funding will enable us to support early-career postdoctoral researchers...

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In ...

Our programme focuses on the care needs of adults living at home with chronic health problems or disabilities, and seeks sustainable solutions to the UK's contemporary 'crisis of care'. It is distinctive in investigating sustainability and wellbeing in care holistically...