• Canada
• 2012-2021close

ESRC : Hester Hockin-Boyers : ES/P000762/1 The Mitacs Globalink UK-Canada doctoral exchange scheme would enable PhD student Hester Hockin-Boyers (Durham University) to spend 12-weeks working with Dr Norman and Professor Vertinsky in the School of Kinesiology at the University of British Columbia (UBC), from September-December 2020. The proposed research will explore how Canadian women's interactions with health and fitness content on Instagram impacts upon physical activity participation. This research is sorely needed because, while social media is increasingly pertinent to the formation of everyday health practices, this dimension is seldom explored. In addition, this project will pilot a novel method, developed by Hockin-Boyers, called 'screenshot elicitation', which seeks to capture the fast, dynamic, mobile and everyday nature of interactions with digital content. Whilst Hockin-Boyers has already begun to develop this technique as part of her PhD research, the Mitacs Globalink project will provide the space and resources to pilot and advance this methodology. The findings resulting from this project have the potential to enhance Canadian women's quality of life, health and wellbeing, by informing digital platform design, social media pedagogies, and public policy in Canada. Furthermore, by providing Hockin-Boyers access to the variety of expertise in Digital Health at UBC, new knowledge and methodological techniques will be brought back to the UK, thus enhancing capacity for further research and innovation

The human mouth contains many different types of microorganisms that are often found attached to oral surfaces in 'sticky' communities called biofilms. These microorganisms are held in close proximity and will therefore likely influence the behaviour of each other. The effects of this could result in increased microbial growth, the displacement of some microorganisms to other sites, the alteration of gene expression and potentially, the enabling of microorganisms to cause infection. A PhD research project being done by Ms Megan Williams at the School of Dentistry, Cardiff University has been exploring how a fungus called Candida albicans can interact both with acrylic surfaces (used to manufacture dentures) and also with bacterial species often found alongside Candida albicans. To date, the work has indicated that colonisation of acrylic coated with different fluids, including those generated from tobacco smoking, may change the way Candida albicans grows. Candida albicans can grow as round cells called yeast, or as filamentous forms called hyphae. It is the hyphal forms that are often considered more damaging to human tissue surfaces during infection. In addition, the research shows that when certain bacteria are grown on acrylic surfaces with Candida albicans, hyphal development is also triggered. This is important, as it may mean that occurrence of infection by Candida albicans is at least in part determined by the community composition of the bacteria present alongside Candida. To date, the methods used to study these effects have included fluorescent microscopy, where the Candida is stained to fluoresce a different colour to bacteria and the surface of attachment. Whilst this approach allows quantification of attachment and imaging of the different growth forms, it cannot determine strength of cell-cell-surface interactions. Atomic Force Microscopy (AFM) is a method that provides images through measuring forces acting between a moving probe and a surface. It is possible to attach different molecules and even whole bacteria to the AFM probe, and in doing so, we can measure interactions occurring between bacteria, and either Candida yeast or hyphae serving as the substrate. Dr Laurent Bozec and his team at the University of Toronto are experts in use of AFM, which is not available in the School of dentistry, Cardiff. The exchange therefore offers the PhD student the opportunity to learn a new experimental technique, generate important data for the PhD and benefit from unique networking experiences. The results generated from this proposal will greatly enhance the research output and complement existing findings of the PhD. Ultimately, this could help determine how bacteria physically interact with Candida albicans and trigger the development of hyphal filaments to facilitate infection.

This proposal builds on - and extends to new audiences and user communities - our NDA funded research project (2009-2012) entitled Ages and Stages: The Place of Theatre in Representations and Recollections of Ageing. It aims to develop some of the activities and research-led learning from that project and, in so doing, reach out to - and bring together - user communities who may not traditionally have worked with drama in the ways proposed here. This will be achieved through the following connected programme of drama-related activities: 1) The formation of an intergenerational theatre company at the New Vic Theatre. Through a regular series of workshops, the company will bring older and younger people together in creative, drama-based activities to enhance understanding between the generations and support the continued social engagement of both groups. 2) A touring performance. The IG company will create a touring piece(s) which can be taken out to audiences within, and beyond, North Staffordshire. We anticipate that these audiences might include local councils; primary as well as secondary schools; residential homes/housing developments for older people; community groups and higher education institutions providing professional training courses (for teachers, social workers and doctors/nurses). 3) An inter-professional training course and training materials/resources, which will aim to develop practice capabilities and age awareness amongst teachers, health and social care professionals, arts practitioners and others interested in learning about and including intergenerational theatre/drama in their practice. The IG company will act as an important resource by contributing to the development and delivery of the training sessions and providing feedback to participants. 4) A scoping exercise for a wider 'Creative Age Festival', which could leave a concrete community legacy from Ages & Stages. The project will continue to be overseen by the existing 'Ages and Stages' Advisory Group, which includes experts in drama, intergenerational practice, policy and gerontology. The group will also be refreshed by new members, including younger members of the intergenerational theatre company (aged 16-18) . The activities we propose are timely for the following reasons. First, there is a notable groundswell of interest in the arts in general and theatre/drama in particular, not simply as a cultural activity but as one which has the potential to impact positively on the well-being of older and younger people. Second, in times of scarce resources, it is important to capitalise on activities which bring people together rather than those which might pit the generations against each other. Third, there is a role for practitioners in facilitating and enabling these kinds of activities but rarely, to our knowledge, have there been opportunities for professionals from differing arenas to work together as is proposed here. Finally, it is important to make best use of existing knowledge - not just that generated from our own work but also that of colleagues. We will be drawing strongly from our collaborators, including our linked Canadian project (about the impact of theatre on health ageing, which runs until 2013), and will also remain part of the New Dynamics of Ageing programme and will benefit from the knowledge exchanges this offers.

Extensive unexploited resources of heavy oil and bitumen exist, for example in Canada and Venezuela, as well as heavier deposits under the North Sea UK, which could potentially be utilized as the production of conventional light crude declines. Heavy oil and bitumen are more difficult to recover than conventional crude, requiring mining or specialized in-situ recovery techniques followed by upgrading to make them suitable for use as a fuel. Toe to heel air injection (THAITM) is an in-situ combustion and upgrading process in which air is injected to a horizontal well to feed combustion of a small fraction of the oil (up to 15 %). The heat generated causes the oil to flow along the well, where thermal upgrading reactions occur, leading to upgrading of the oil (by 4-6 API). CAPRI is a catalytic add-on to THAI in which catalyst is packed around the well to effect further catalytic upgrading reactions, such as hydrotreatment, however previous studies showed that the catalyst lifetime and process effectiveness are limited by coke deposition upon the catalyst. Additionally the costs and challenges of packing the well with pelleted catalyst prior to starting up also make the CAPRI process less economically attractive. The current proposal seeks to develop cheap, effective nanoparticulate catalysts which could be conveyed into the well by air or as slurry during operation, thereby avoiding the requirement for packing the well with catalyst prior to start up and to reduce the amount of deactivation and bed blockage that occurs by coke deposition upon pelleted catalysts. Initially, readily available iron oxide nanoparticles will be tested as a base-case. Nanoparticulate catalysts will also be prepared by supporting the metal upon bacteria, using a method in which metal containing solution is reduced in the presence of a bacterial culture, followed by centrifuge and drying which kills the live bacteria. The method has the advantages of being able to utilize scrap metal solutions and thus facilitate recycling of metals from waste sources, and it may be tuned to engineer nanoparticles of desired size and properties (e.g. crystal structures). Here we seek to develop, test and scale up the production of biogenic Fe catalysts for the upgrading of oil in the THAI process. Furthermore, waste road dusts contain deposits of catalytic metals from the exhaust of vehicular catalytic converters and these will be converted into cheap mixed metal catalysts by economically proven biohydrometallurgical methods for testing in the THAI process. Key to the effectiveness of utilizing nanoparticle catalysts will be the ability to contact them with oil in the mobile oil zone and flame front of the well, where the reaction is taking place. Studies of the rock void structure will be carried out using techniques such as X-Ray microtomography. Monte Carlo and Lattice Boltzmann simulations will be used to study the pneumatic conveying of particles into the reservoir and to study penetration and distribution of particles within the void space of the rocks. Conveying of slurry catalysts and process performance will be modeled using STARS reservoir simulation software. Evaluation of the different catalysts will be performed experimentally under real conditions using a rig developed under a previous project. The effect of variables such as gas:oil ratio, temperature, pressure and gas composition will be studied experimentally, in order to select the best catalyst and understand the conditions required for maximum upgrading. The experiments will also indicate whether catalyst deactivation occurs during use and enable conditions to be tuned to avoid deactivation.

Rare diseases (RD) are diseases that affect not more than 5 per 10 000 persons (according to the EU definition). 7000 distinct rare diseases exist, affecting between 6% and 8% of the population (about 30 million EU citizens). The lack of specific health policies for rare diseases and the scarcity of the expertise, translate into delayed diagnosis, few medicinal products and difficult access to care. That is why rare diseases are a prime example of a research area that strongly profits from coordination on a European scale. At present only few European countries fund research on rare diseases through specific dedicated programmes. Therefore, the funding of transnational collaborative research is the most effective joint activity to enhance the cooperation between scientists working on rare diseases in Europe and beyond. The E-Rare consortium was built to link responsible funding bodies that combine the scarce resources and fund rare disease research via Joint Transnational Calls (JTCs). The current E-Rare-3 project proposal will extend and strengthen the transnational cooperation by building on the experience and results of the previous E-Rare-1&2 programmes. The consortium comprises 26 institutions from 17 European, Associated and non-European countries. Its international dimension will be directly translated into close collaboration with IRDiRC and other relevant European and international initiatives. IRDiRC guidelines and policies will be implemented in the four JTCs and representatives of the IRDiRC Scientific Committees will be invited to join the Advisory Board of E-Rare-3. Members of the EUCERD group will be involved in identifying rare disease research needs. Patients’ organizations from Europe (represented by EURORDIS) and beyond will be invited as a key partner towards collaborative efforts for research promotion and funding. The collaboration with European Research Infrastructures will be consolidated to enhance efficient and participative research.