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The motivation for this proposal is that the global reliance on fossil fuels is set to increase with the rapid growth of Asian economies and major discoveries of shale gas in developed nations. The strategic vision of the IDC is to develop a world-leading Centre for Industrial Doctoral Training focussed on delivering research leaders and next-generation innovators with broad economic, societal and contextual awareness, having strong technical skills and capable of operating in multi-disciplinary teams covering a range of knowledge transfer, deployment and policy roles. They will be able to analyse the overall economic context of projects and be aware of their social and ethical implications. These skills will enable them to contribute to stimulating UK-based industry to develop next-generation technologies to reduce greenhouse gas emissions from fossil fuels and ultimately improve the UK's position globally through increased jobs and exports. The Centre will involve over 50 recognised academics in carbon capture & storage (CCS) and cleaner fossil energy to provide comprehensive supervisory capacity across the theme for 70 doctoral students. It will provide an innovative training programme co-created in collaboration with our industrial partners to meet their advanced skills needs. The industrial letters of support demonstrate a strong need for the proposed Centre in terms of research to be conducted and PhDs that will be produced, with 10 new companies willing to join the proposed Centre including EDF Energy, Siemens, BOC Linde and Caterpillar, together with software companies, such as ANSYS, involved with power plant and CCS simulation. We maintain strong support from our current partners that include Doosan Babcock, Alstom Power, Air Products, the Energy Technologies Institute (ETI), Tata Steel, SSE, RWE npower, Johnson Matthey, E.ON, CPL Industries, Clean Coal Ltd and Innospec, together with the Biomass & Fossil Fuels Research Alliance (BF2RA), a grouping of companies across the power sector. Further, we have engaged SMEs, including CMCL Innovation, 2Co Energy, PSE and C-Capture, that have recently received Department of Energy and Climate Change (DECC)/Technology Strategy Board (TSB)/ETI/EC support for CCS projects. The active involvement companies have in the research projects, make an IDC the most effective form of CDT to directly contribute to the UK maintaining a strong R&D base across the fossil energy power and allied sectors and to meet the aims of the DECC CCS Roadmap in enabling industry to define projects fitting their R&D priorities. The major technical challenges over the next 10-20 years identified by our industrial partners are: (i) implementing new, more flexible and efficient fossil fuel power plant to meet peak demand as recognised by electricity market reform incentives in the Energy Bill, with efficiency improvements involving materials challenges and maximising biomass use in coal-fired plant; (ii) deploying CCS at commercial scale for near-zero emission power plant and developing cost reduction technologies which involves improving first-generation solvent-based capture processes, developing next-generation capture processes, and understanding the impact of impurities on CO2 transport and storage; (iimaximising the potential of unconventional gas, including shale gas, 'tight' gas and syngas produced from underground coal gasification; and (iii) developing technologies for vastly reduced CO2 emissions in other industrial sectors: iron and steel making, cement, refineries, domestic fuels and small-scale diesel power generatort and These challenges match closely those defined in EPSRC's Priority Area of 'CCS and cleaner fossil energy'. Further, they cover biomass firing in conventional plant defined in the Bioenergy Priority Area, where specific issues concern erosion, corrosion, slagging, fouling and overall supply chain economics.

The aim of the centre is to train research engineers with skills and expertise at the forefront of knowledge in machining science. Machining is at the heart of almost all manufacturing processes, ranging from the milling and turning processes used to create parts for the air-craft engines that power the planes we travel on, through to the grinding processes used to shape replacement hip-joints. As we demand more from engineered components, and move to materials such as composites or high strength alloys, their intrinsic strength or complexity as materials makes them harder to machine. This frequently means that machining processes are slower, require more manual interventions, and produce more out of tolerance parts: all these factors result in higher costs. Research into machining science can make a tangible difference to the way in which modern engineering components are produced. For example, recent machining research by the AMRC will be used at Rolls-Royce's new 20,000 square metre factory in Tyne & Wear. This factory will employ over 400 people and make over 2000 engine components per year, for aircraft including the Boeing 786 Dreamliner and the Airbus A380 [1]. Our doctoral training centre will equip research engineers with the skills and expertise that places them at the forefront of machining science. Cohorts of doctoral researchers will each work on an industrially posed machining problem. They will aim to bridge the gap between industry and academia, as they will first research areas of appropriate machining science, before transferring this technology to their sponsor company. Research and training will take place within a collaborative environment, with research engineers based in the Advanced Manufacturing Research Centre (AMRC) in Sheffield, where they will be mentored by academics working at the forefront of machining science, and will have access to some of the latest equipment available. Industrial participation is central to our training vision, where in addition to working on an industrially proposed problem, each research engineer will be co- funded and supervised by industry. We see this interaction as essential to ensure the research and training we provide is timely, and addresses the key challenges posed by UK industry. [1] Rolls-Royce press release, Friday, 21 September 2012. "Rolls-Royce breaks ground for new facility in North East"

We propose a Centre for Doctoral Training in Integrative Sensing and Measurement that addresses the unmet UK need for specialist training in innovative sensing and measurement systems identified by EPSRC priorities the TSB and EPOSS . The proposed CDT will benefit from the strategic, targeted investment of >£20M by the partners in enhancing sensing and measurement research capability and by alignment with the complementary, industry-focused Innovation Centre in Sensor and Imaging Systems (CENSIS). This investment provides both the breadth and depth required to provide high quality cohort-based training in sensing across the sciences, medicine and engineering and into the myriad of sensing applications, whilst ensuring PhD supervision by well-resourced internationally leading academics with a passion for sensor science and technology. The synergistic partnership of GU and UoE with their active sensors-related research collaborations with over 160 companies provides a unique research excellence and capability to provide a dynamic and innovative research programme in sensing and measurement to fuel the development pipeline from initial concept to industrial exploitation.

Quantum technologies promise a transformation of measurement, communication and computation by using ideas originating from quantum physics. The UK was the birthplace of many of the seminal ideas and techniques; the technologies are now ready to translate from the laboratory into industrial applications. Since international companies are already moving in this area, there is a critical need across the UK for highly-skilled researchers who will be the future leaders in quantum technology. Our proposal is driven by the need to train this new generation of leaders. They will need to be equipped to function in a complex research and engineering landscape where quantum physics meets cryptography, complexity and information theory, devices, materials, software and hardware engineering. We propose to train a cohort of leaders to meet these challenges within the highly interdisciplinary research environment provided by UCL, its commercial and governmental laboratory partners. In their first year the students will obtain a background in devices, information and computational sciences through three concentrated modules organized around current research issues. They will complete a team project and a longer individual research project, preparing them for their choice of main research doctoral topic at the end of the year. Cross-cohort training in communication skills, technology transfer, enterprise, teamwork and career planning will continue throughout the four years. Peer to peer learning will be continually facilitated not only by organized cross-cohort activities, but also by the day to day social interaction among the members of the cohort thanks to their co-location at UCL.

Boreal regions hold upwards of 60% of the planet's freshwater, an essential ingredient for all life. But human activities, such as climate and land use change, are dramatically altering these landscapes and threatening the delivery of key services provided by aquatic ecosystems, such as clean drinking water and healthy fish populations. Contemporary paradigms of aquatic conservation have emphasized inputs of pollutants and water resource development as causes of declining water security and biodiversity, but restoration attempts are failing when these two factors alone are improved. Increasingly, local watersheds are seen as critical controls of aquatic ecosystems. This is spurred by the recent discovery that pathways of energy mobilization upwards through aquatic food webs - from microbes to fish - rely on organic matter originating from terrestrial vegetation, proving the adage that "clean water is a forest product". Any factor that changes the quality and quantity of organic matter input into freshwater from their surrounding catchments will clearly influence the delivery of aquatic ecosystem services. Fire, forest pests, and resource development, such as mining and logging, are emerging disturbances that are transforming boreal regions, but little is known as to how they will change long-term cycling of nutrients from terrestrial vegetation into aquatic ecosystems. A new watershed-level science that integrates the management of forestry and water resources is clearly needed to inform decision makers of the actions needed to conserve freshwater supplies by linking actions on land to processes in water. Our research will test whether the productivity of aquatic food webs increases with the quantity and quality of terrestrial organic matter under different climate scenarios. We will also answer whether disturbances on land that remove plant biomass and change the quality of plant litter will dampen the productivity of freshwater plants and animals. Our approach will be to create 96 artificial ecosystems in a common lake environment and expose sites to different quantities and qualities of organic matter. We will measure the responses of microbial, algal, and grazer communities using cutting-edge technologies such as next-generation DNA sequencing. We will also plant tagged individuals of a sedentary mussel species closely-related to economically important taxa within each site and monitor their long-term growth and survival. The ultimate goal of this work is to develop a spatially-explicit, dynamical watershed-level simulation model. We want to answer the question if X% of habitat is consumed by fire or insect outbreaks, then food stocks for fish will change by Y%. Outcomes of this research will be highly relevant to the UK and international policy around managing freshwater supplies by demonstrating strong linkages between terrestrial and aquatic ecosystems. For example, the EU has developed legislation to protect freshwater but this ignores the effects of land use practices on lake water quality and biota. The future of extensive forestry plantations and pastures surrounding many socio-economically important watersheds in Britain are also being debated as the EU begins reforming the Common Agricultural Policy. We aim to show that any changes in land use must consider how energy in the form of organic matter is dispersed to aquatic ecosystems and supports their productivity. Finally, this project will have many applications for improving regional land use planning and management, as well as restoring environmentally damaged landscapes. We will work closely with partners in the mining industry and government to inform them of the best practices for re-vegetating degraded watersheds.

Mathematics is a profound intellectual achievement with impact on all aspects of business and society. For centuries, the highest level of mathematics has been seen as an isolated creative activity, to produce a proof for review and acceptance by research peers. Mathematics is now at a remarkable inflexion point, with new technology radically extending the power and limits of individuals. "Crowdsourcing" pulls together diverse experts to solve problems; symbolic computation tackles huge routine calculations; and computers check proofs that are just too long and complicated for any human to comprehend, using programs designed to verify hardware. Yet these techniques are currently used in stand-alone fashion, lacking integration with each other or with human creativity or fallibility. Social machines are new paradigm, identified by Berners-Lee, for viewing a combination of people and computers as a single problem-solving entity. Our long-term vision is to change mathematics, transforming the reach, pace, and impact of mathematics research, through creating a mathematics social machine: a combination of people, computers, and archives to create and apply mathematics. Thus, for example, an industry researcher wanting to design a network with specific properties could quickly access diverse research skills and research; explore hypotheses; discuss possible solutions; obtain surety of correctness to a desired level; and create new mathematics that individual effort might never imagine or verify. Seamlessly integrated "under the hood" might be a mixture of diverse people and machines, formal and informal approaches, old and new mathematics, experiment and proof. The obstacles to realising the vision are that (i) We do not have a high level understanding of the production of mathematics by people and machines, integrating the current diverse research approaches (ii) There is no shared view among the diverse re- search and user communities of what is and might be possible or desirable The outcome of the fellowship will be a new vision of a mathematics social machine, transforming the reach, pace and impact of mathematics. It will deliver: analysis and experiment to understand current and future production of mathematics as a social machine; designs and prototypes; ownership among academic and industry stakeholders; a roadmap for delivery of the next generation of social machines; and an international team ready to make it a reality.

The Hub will create a seamless link between science and applications by building on our established knowledge exchange activities in quantum technologies. We will transform science into technology by developing new products, demonstrating their applications and advantages, and establishing a strong user base in diverse sectors. Our overarching ambition is to deliver a wide range of quantum sensors to underpin many new commercial applications. Our key objective is to ensure that the Hub's outputs will have been picked up by companies, or industry-led TSB projects, by the end of the funding period. The Hub will comprise: a strong fabrication component; quantum scientists with a demonstrated ability to combine scientific excellence with technological delivery; leading engineers with the broad collective expertise and connections required to develop and use new quantum sensors. We have identified, and actively involved, industry enablers to build a supply chain for quantum sensor technology. As well as direct physics connections to industry, the engineers provide strong links to relevant industrial users, thus providing information on industrial needs and enabling rapid prototype deployment in the field. To establish a coherent national collaborative effort, the Hub will include a UK network on quantum sensors and metrology, which will also exploit the connections that Prof Bongs and all Hub members have forged in Europe, the US and Asia. This inter-linkage ensures capture of the most advanced developments in quantum technology around the world for exploitation by the UK. Quantum sensors and metrology, plus some devices in quantum communication, are the only areas where laboratory prototypes have already proven superior to their best classical counterparts. This sets the stage, credibly, for rapid and disruptive applications emerging from the Hub. The selection of prototypes will be driven by commercial pull, i.e. each prototype project within the Hub must demonstrate, from the outset, industry or practitioner engagement from our engineering and/or industrial collaborators. We have strong industry support across several disciplines with the structures in place actively to manage technology and knowledge transfer to the industry sector. Particular roles are played by NPL and e2V. We will closely collaborate with NPL as metrology end-user on clock, magnetometer and potentially Watt balance developments with a lecturer-level Birmingham-NPL fellow contributed by Birmingham University and our PRDAs spending ~17 man-years in addition to 3-5 PhD students on these joint projects in the Advanced Metrology Laboratory/incubator space. E2v have a unique industrial manufacturing/R&D facility co-located within the School of Physics and Astronomy at Nottingham that has already catalysed the expansion of their activities into the Quantum Technology domain. Public Engagement conveying the Hub's breakthroughs will be a high priority - for example annually at the Royal Society Summer Exhibitions. In addition to cohort-training of 80 PhD students working within the Hub, the Hub will contribute to the training of ~500 PhD students via electronically-shared lectures (many already running within the e-learning graduate schools MPAGS, MEGS, SEPNET and SUPA) across the institutions within the Hub. The Hub will create an internationally-leading centre of excellence with major impact in the area of quantum sensors and metrology. To widen the impact of the Hub and ensure long-term sustainability, we will actively pursue European and other international collaborative funding for both underlying fundamental research and the technology development.

30 years' research on metal biorecovery from wastes has paid scant attention to strong CONTEMPORARY demands for (i) conservation of dwindling vital resources (e.g platinum group metals (PGM), recently rare earth elements, (REE), base metals (BMs) and uranium) and (ii) the unequivocal need to extract/refine them in a non-polluting, low-energy way. 21stC technologies increasingly rely on nanomaterials which have novel properties not seen in bulk materials. Bacteria can fabricate nanoparticles (NPs), bottom up, atom by atom, with exquisite fine control offered by enzymatic synthesis and bio-scaffolding that chemistry cannot emulate. Bio-nanoparticles have proven applications in green chemistry, low carbon energy, environmental protection and potentially in photonic applications. Bacteria can be grown cheaply at scale for facile production. We have shown that bacteria can make nanomaterials from secondary wastes, yielding, in some cases, a metallic mixture which can show better activity than 'pure' nanoparticles. Such fabrication of structured bimetallics can be hard to achieve chemically. For some metals like rare earths and uranium (which often co-occur in wastes) their biorecovery from scraps e.g. magnets (rare earths) and wastes (mixed U/rare earths), when separated, can make 'enriched' solids for delivery into further commercial refining to make new magnets (rare earths) or nuclear fuel (U). Biofabricating these solids is often beyond the ability of living cells but they can form scaffolds, with enzymatic processes harnessed to make biomineral precursors, often selectively. B3 will invoke tiered levels of complexity, maturity and risk. (i) Base metal mining wastes (e.g. Cu, Ni) will be biorefined into concentrated sludges for chemical reprocessing or alternatively to make base metal-bionanoproducts. (ii) Precious metal wastes will be converted into bionanomaterials for catalysis, environmental and energy applications. (iii) Rare earth metal wastes will be biomineralised for enriched feed into further refining or into new catalysts. (iv) Uranium-waste will be biorefined into mineral precursors for commercial nuclear fuels. In all, the environment will be spared dual impacts of both primary source pollution AND the high energy demand of processing from primary 'crude'. Metallic scraps are tougher, requiring acids for dissolution. Approaches will include the use of acidophilic bacteria, use of alkalinizing enzymes or using bacteria to first make a chemical catalyst (benignly) which can then convert the target metal of interest from the leachate into new nanomaterials (a hybrid living/nonliving system, already shown). Environmentally-friendly leaching & acids recycle will be evaluated and leaching processes optimised via extant predictive models. The interface between biology, chemistry, mineralogy and physics, exemplified by nanoparticles held in their unique 'biochemical nest', will receive special focus, being where major discoveries will be made; cutting edge technologies will relate structure to function, and validate the contribution of upstream waste doping or 'blending'; these, as well as novel materials processing, will increase bio-nanoparticle efficacy. Secondary wastes to be biorefined will include magnet scraps (rare earths), print cartridges (precious metals), road dusts (PMs, Fe,Ce) & metallurgical wastes (mixed rare earths/base metals/uranium). Their complex, often refractory nature gives a higher 'risk' than mine wastes but in compensation, the volumes are lower, & the scope for 'doping' or 'steering' to fabricate/steer engineered nanomaterials is correspondingly higher. B3 will have an embedded significant (~15%) Life Cycle Analysis iterative assessment of highlighted systems, with end-user trialling (supply chains; validations in conjunction with an industrial platform). B3 welcomes new 'joiners' from a raft of problem holders brought via Partner network backup.

The Scottish Doctoral Training Centre in Condensed Matter Physics, known as the CM-DTC, is an EPSRC-funded Centre for Doctoral Training (CDT) addressing the broad field of Condensed Matter Physics (CMP). CMP is a core discipline that underpins many other areas of science, and is one of the Priority Areas for this CDT call. Renewal funding for the CM-DTC will allow five more annual cohorts of PhD students to be recruited, trained and released onto the market. They will be highly educated professionals with a knowledge of the field, in depth and in breadth, that will equip them for future leadership in a variety of academic and industrial careers. Condensed Matter Physics research impacts on many other fields of science including engineering, biophysics, photonics, chemistry, and materials science. It is a significant engine for innovation and drives new technologies. Recent examples include the use of liquid crystals for displays including flat-screen and 3D television, and the use of solid-state or polymeric LEDs for power-saving high-illumination lighting systems. Future examples may involve harnessing the potential of graphene (the world's thinnest and strongest sheet-like material), or the creation of exotic low-temperature materials whose properties may enable the design of radically new types of (quantum) computer with which to solve some of the hardest problems of mathematics. The UK's continued ability to deliver transformative technologies of this character requires highly trained CMP researchers such as those the Centre will produce. The proposed training approach is built on a strong framework of taught lecture courses, with core components and a wide choice of electives. This spans the first two years so that PhD research begins alongside the coursework from the outset. It is complemented by hands-on training in areas such as computer-intensive physics and instrument building (including workshop skills and 3D printing). Some lecture courses are delivered in residential schools but most are videoconferenced live, using the well-established infrastructure of SUPA (the Scottish Universities Physics Alliance). Students meet face to face frequently, often for more than one day, at cohort-building events that emphasise teamwork in science, outreach, transferable skills and careers training. National demand for our graduates is demonstrated by the large number of companies and organisations who have chosen to be formally affiliated with our CDT as Industrial Associates. The range of sectors spanned by these Associates is notable. Some, such as e2v and Oxford Instruments, are scientific consultancies and manufacturers of scientific equipment, whom one would expect to be among our core stakeholders. Less obviously, the list also represents scientific publishers, software houses, companies small and large from the energy sector, large multinationals such as Solvay-Rhodia and Siemens, and finance and patent law firms. This demonstrates a key attraction of our graduates: their high levels of core skills, and a hands-on approach to problem solving. These impart a discipline-hopping ability which more focussed training for specific sectors can complement, but not replace. This breadth is prized by employers in a fast-changing environment where years of vocational training can sometimes be undermined very rapidly by unexpected innovation in an apparently unrelated sector. As the UK builds its technological future by funding new CDTs across a range of priority areas, it is vital to include some that focus on core discipline skills, specifically Condensed Matter Physics, rather than the interdisciplinary or semi-vocational training that features in many other CDTs. As well as complementing those important activities today, our highly trained PhD graduates will be equipped to lay the foundations for the research fields (and perhaps some of the industrial sectors) of tomorrow.

Life expectancies in the UK have increased rapidly over the last century. If this continues, recent studies have predicted that the majority of babies born since 2000 will live to 100. Our ageing population poses serious economic and medical problems, unless we can find ways of alleviating the process of physiological deterioration and many diseases that are associated with old age. Simple biological measures (or 'biomarkers') capable of illuminating the wider process of ageing and predicting the onset of common diseases of old age could provide important new understanding of the underlying causes of individual variation in ageing rates, as well as interventions to promote healthy ageing. Telomere length (TL) is an exciting candidate biomarker of ageing. Telomeres cap and protect our chromosomes and become shorter with each cell division. When telomeres become very short, cells stop functioning properly, with potentially negative consequences for wider bodily function. Accordingly, the process of telomere attrition is thought to play an important role in the way we age. In humans, telomeres are usually measured in white blood cells, because blood is relatively easy to obtain, and average TL of these cells declines with age. Excitingly, short TL in adulthood predicts various age-related diseases and reduced subsequent survival. However, age only explains a small part of the massive variation in TL among individuals, and we currently do not know why adult TL varies so much. Is it because of genetic or environmental effects on TL at birth, or is it down to differences in growth rates or experiences through early life and adulthood which affect the rate of telomere shortening? To answer this question we need blood samples and information over the entire lifetimes of individuals. This has not been possible in humans because we are so long lived. Furthermore, there are considerable differences in the telomere biology of short-lived and long-lived mammals, so laboratory mice may be poor models for humans. In this project, we will use a remarkably detailed long-term study of Soay sheep on St Kilda to tackle the question of how and why TL varies across the entire lifespan and what this means for the ageing process. It might seem odd to be using wild sheep on a remote island for such a purpose. In fact, the telomere biology of sheep and humans is similar, and the Soay sheep are one of the most closely monitored populations of mammals anywhere in the world. Since 1985, every sheep has been individually marked and followed closely across its lifetime, so we know how quickly they grew, when they bred, where they lived, when they died and we have detailed information on their genetics and the environmental conditions they experience. Importantly, we also regularly re-capture these animals and have collected blood samples repeatedly from around 3000 individuals all the way from birth to death. We will measure TL from archived blood samples to test whether differences in TL in late adulthood are mainly the result of differences in TL at birth or in telomere loss thereafter. We will also test how genes and environment during development influence TL and how natural selection acts on variation in TL. The uniquely detailed, life-long nature of our study will provide the first tests of the causes of individual variation in telomere attrition rates across the entire lifespan of a long-lived mammal. We will also extend the fieldwork on St Kilda to collect samples for more extensive telomere and immunological analyses. Laboratory studies show that a few very short telomeres are enough to compromise cell function, and in white blood cells this could compromise our immune system. Using newly-collected field data and blood samples, we will test both of these predictions outside of the lab for the first time, shedding new light on how changes in TL may influence our ability to fight disease, maintain health and survive in later adulthood.