• Canada
• 2014 close

Rare diseases (RD) are diseases that affect not more than 5 per 10 000 persons (according to the EU definition). 7000 distinct rare diseases exist, affecting between 6% and 8% of the population (about 30 million EU citizens). The lack of specific health policies for rare diseases and the scarcity of the expertise, translate into delayed diagnosis, few medicinal products and difficult access to care. That is why rare diseases are a prime example of a research area that strongly profits from coordination on a European scale. At present only few European countries fund research on rare diseases through specific dedicated programmes. Therefore, the funding of transnational collaborative research is the most effective joint activity to enhance the cooperation between scientists working on rare diseases in Europe and beyond. The E-Rare consortium was built to link responsible funding bodies that combine the scarce resources and fund rare disease research via Joint Transnational Calls (JTCs). The current E-Rare-3 project proposal will extend and strengthen the transnational cooperation by building on the experience and results of the previous E-Rare-1&2 programmes. The consortium comprises 26 institutions from 17 European, Associated and non-European countries. Its international dimension will be directly translated into close collaboration with IRDiRC and other relevant European and international initiatives. IRDiRC guidelines and policies will be implemented in the four JTCs and representatives of the IRDiRC Scientific Committees will be invited to join the Advisory Board of E-Rare-3. Members of the EUCERD group will be involved in identifying rare disease research needs. Patients’ organizations from Europe (represented by EURORDIS) and beyond will be invited as a key partner towards collaborative efforts for research promotion and funding. The collaboration with European Research Infrastructures will be consolidated to enhance efficient and participative research.

The motivation for this proposal is that the global reliance on fossil fuels is set to increase with the rapid growth of Asian economies and major discoveries of shale gas in developed nations. The strategic vision of the IDC is to develop a world-leading Centre for Industrial Doctoral Training focussed on delivering research leaders and next-generation innovators with broad economic, societal and contextual awareness, having strong technical skills and capable of operating in multi-disciplinary teams covering a range of knowledge transfer, deployment and policy roles. They will be able to analyse the overall economic context of projects and be aware of their social and ethical implications. These skills will enable them to contribute to stimulating UK-based industry to develop next-generation technologies to reduce greenhouse gas emissions from fossil fuels and ultimately improve the UK's position globally through increased jobs and exports. The Centre will involve over 50 recognised academics in carbon capture & storage (CCS) and cleaner fossil energy to provide comprehensive supervisory capacity across the theme for 70 doctoral students. It will provide an innovative training programme co-created in collaboration with our industrial partners to meet their advanced skills needs. The industrial letters of support demonstrate a strong need for the proposed Centre in terms of research to be conducted and PhDs that will be produced, with 10 new companies willing to join the proposed Centre including EDF Energy, Siemens, BOC Linde and Caterpillar, together with software companies, such as ANSYS, involved with power plant and CCS simulation. We maintain strong support from our current partners that include Doosan Babcock, Alstom Power, Air Products, the Energy Technologies Institute (ETI), Tata Steel, SSE, RWE npower, Johnson Matthey, E.ON, CPL Industries, Clean Coal Ltd and Innospec, together with the Biomass & Fossil Fuels Research Alliance (BF2RA), a grouping of companies across the power sector. Further, we have engaged SMEs, including CMCL Innovation, 2Co Energy, PSE and C-Capture, that have recently received Department of Energy and Climate Change (DECC)/Technology Strategy Board (TSB)/ETI/EC support for CCS projects. The active involvement companies have in the research projects, make an IDC the most effective form of CDT to directly contribute to the UK maintaining a strong R&D base across the fossil energy power and allied sectors and to meet the aims of the DECC CCS Roadmap in enabling industry to define projects fitting their R&D priorities. The major technical challenges over the next 10-20 years identified by our industrial partners are: (i) implementing new, more flexible and efficient fossil fuel power plant to meet peak demand as recognised by electricity market reform incentives in the Energy Bill, with efficiency improvements involving materials challenges and maximising biomass use in coal-fired plant; (ii) deploying CCS at commercial scale for near-zero emission power plant and developing cost reduction technologies which involves improving first-generation solvent-based capture processes, developing next-generation capture processes, and understanding the impact of impurities on CO2 transport and storage; (iimaximising the potential of unconventional gas, including shale gas, 'tight' gas and syngas produced from underground coal gasification; and (iii) developing technologies for vastly reduced CO2 emissions in other industrial sectors: iron and steel making, cement, refineries, domestic fuels and small-scale diesel power generatort and These challenges match closely those defined in EPSRC's Priority Area of 'CCS and cleaner fossil energy'. Further, they cover biomass firing in conventional plant defined in the Bioenergy Priority Area, where specific issues concern erosion, corrosion, slagging, fouling and overall supply chain economics.

The shift from hunting and gathering to an agricultural way of life was one of the most profound events in the history of our species and one which continues to impact our existence today. Understanding this process is key to understanding the origins and rise of human civilization. Despite decades of study, however, fundamental questions regarding why, where and how it occurred remain largely unanswered. Such a fundamental change in human existence could not have been possible without the domestication of selected animals and plants. The dog is crucial in this story since it was not only the first ever domestic animal, but also the only animal to be domesticated by hunter-gatherers several thousand years before the appearance of farmers. The bones and teeth of early domestic dogs and their wild wolf ancestors hold important clues to our understanding of how, where and when humans and wild animals began the relationship we still depend upon today. These remains have been recovered from as early as 15,000 years ago in numerous archaeological sites across Eurasia suggesting that dogs were either domesticated independently on several occasions across the Old World, or that dogs were domesticated just once and subsequently spreading with late Stone Age hunter gatherers across the Eurasian continent and into North America. There are also those who suggest that wolves were involved in an earlier, failed domestication experiment by Ice Age Palaeolithic hunters about 32,000 years ago. Despite the fact that we generally know the timing and locations of the domestication of all the other farmyard animals, we still know very little for certain about the origins of our most iconic domestic animal. New scientific techniques that include the combination of genetics and statistical analyses of the shapes of ancient bones and teeth are beginning to provide unique insights into the biology of the domestication process itself, as well as new ways of tracking the spread of humans and their domestic animals around the globe. By employing these techniques we will be able to observe the variation that existed in early wolf populations at different levels of biological organization, identify diagnostic signatures that pinpoint which ancestral wolf populations were involved in early dog domestication, reveal the shape (and possibly the genetic) signatures specifically linked to the domestication process and track those signatures through time and space. We have used this combined approach successfully in our previous research enabling us to definitively unravel the complex story of pig domestication in both Europe and the Far East. We have shown that pigs were domesticated multiple times and in multiple places across Eurasia, and the fine-scale resolution of the data we have generated has also allowed us to reveal the migration routes pigs took with early farmers across Europe and into the Pacific. By applying this successful research model to ancient dogs and wolves, we will gain much deeper insight into the fundamental questions that still surround the story of dog domestication.

This research will create a truly innovative, international research network that will stretch far and wide in the area of "Cultures of Creativity and Innovation in Design". The international research network coordinating body comprises Professors Paul Rodgers and Paul Jones from Northumbria University, Professor Amaresh Chakrabarti, a world-leading researcher in Design Creativity, from the Centre for Product Design and Manufacturing at the Indian Institute of Science, Bangalore and Professor Lorenzo Imbesi, an internationally-acclaimed researcher in Design Culture, from the School of Industrial Design at Carleton University, Canada. The importance of creativity in the cultural, creative and other industries and the significant contributions that creativity adds to a nation's overall GDP and the subsequent health and wellbeing of its people cannot be overstated. In Europe, the value of the cultural and creative industries is estimated at well over 700 billion Euros each year, twice that of Europe's car manufacturing industry. The value of creativity and innovation, to any nation, is therefore huge. Creativity and innovation adds real value, which enables a number of benefits such as economic growth and social wellbeing. In many societies creativity epitomises success, excitement and value. Whether driven by individuals, companies, enterprises or regions creativity and innovation establishes immediate empathy, and conveys an image of dynamism. Creativity is thus a positive word in societies constantly aspiring to innovation and progress. In short, creativity in all of its manifestations enriches society. This network seeks to gain an understanding of this dynamic ecology that creativity and innovation bring to society. Creativity is a vital ingredient in the production of products, services and systems, both in the cultural industries and across the economy as a whole. Yet despite its importance and the ubiquitous use of creativity as a term there are issues regarding its definitional clarity. A better understanding and articulation of creativity as a concept and a process would support enhanced future innovation. Socio-cultural approaches to creativity explain that creative ideas or products do not happen inside people's heads, but in the interaction between a person's thoughts and a socio-cultural context. It is acknowledged that creativity cannot be taught, but that it can be cultivated and this has significant implications for a nation's design and innovation culture. It is known that creativity flourishes in congenial environments and in creative climates. This research will examine how creativity is valued, exploited, and facilitated across different national and cultural settings as all can have a major impact on a nation's creative potential. The key aim of this network is to investigate attitudes about creativity and how it is best cultivated and exploited across three different geographical locations (UK, India, and Canada), different environments, and cultures from both an individual designer's perspective and design groups' perspectives. The network seeks to investigate cultures of creativity and innovation in design and question its nature. For instance, can creativity be adequately conceptualised in a design context? What role do cultural organisations and national bodies play in harnessing creativity? Where do the "edges" lie between creativity and innovation? Do richer environments and approaches for facilitating creativity exist? What design skills, knowledge, and expertise are required for creativity? Moreover, what are the key drivers that motivate the creativity and innovation of designers and other stakeholders? Are they economical, cultural, social, or political? This research network will host 3 workshops, each one facilitating inquiry amongst invited design practitioners, researchers, educators and other stakeholders involved in design practice.