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description Publicationkeyboard_double_arrow_right Article , Report , Other literature type , Preprint 2018 Turkey, Italy, Italy, Germany, Portugal, Portugal, Italy, United Kingdom, Italy, Italy, Spain, Denmark, Italy, Poland, Italy, Italy, France, ItalySpringer Science and Business Media LLC Aaboud M.; Aad G.; Abbott B.; Abdinov O.; Abeloos B.; Abhayasinghe D. K.; Abidi S. H.; Abouzeid O. S.; Abraham N. L.; Abramowicz H.; Abreu H.; Abulaiti Y.; Acharya B. S.; Adachi S.; Adam L.; Adamczyk L.; Adelman J.; Adersberger M.; Adiguzel A.; Adye T.; Affolder A. A.; Afik Y.; Agheorghiesei C.; Aguilar-Saavedra J. A.; Ahmadov F.; Aielli G.; Akatsuka S.; Åkesson T. P. A.; Akilli E.; Akimov A. V.; Alberghi G. L.; Albert J.; Albicocco P.; Alconada Verzini M. J.; Alderweireldt S.; Aleksa M.; Aleksandrov I. N.; Alexa C.; Alexopoulos T.; Alhroob M.; Ali B.; Alimonti G.; Alison J.; Alkire S. P.; Allaire C.; Allbrooke B. M. M.; Allen B. W.; Allport P. P.; Aloisio A.; Alonso A.; Alonso F.; Alpigiani C.; Alshehri A. A.; Alstaty M. I.; Alvarez Gonzalez B.; Álvarez Piqueras D.; Alviggi M. G.; Amadio B. T.; Amaral Coutinho Y.; Ambler A.; Ambroz L.; Amelung C.; Amidei D.; Amor Dos Santos S. P.; Amoroso S.; Amrouche C. S.; Anastopoulos C.; Ancu L. S.; Andari N.; Andeen T.; Anders C. F.; Anders J. K.; Anderson K. J.; Andreazza A.; Andrei V.; Anelli C. R.; Angelidakis S.; Angelozzi I.; Angerami A.; Anisenkov A. V.; Annovi A.; Antel C.; Anthony M. T.; Antonelli M.; Antrim D. J. A.; Anulli F.; Aoki M.; Aparisi Pozo J. A.; Aperio Bella L.; Arabidze G.; Araque J. P.; Araujo Ferraz V.; Araujo Pereira R.; Arce A. T. H.; Ardell R. E.; Arduh F. A.; Arguin J. -F.; Argyropoulos S.; Armbruster A. J.; Armitage L. J.; Armstrong A.; Arnaez O.; Arnold H.; Arratia M.; Arslan O.; Artamonov A.; Artoni G.; Artz S.; Asai S.; Asbah N.; Asimakopoulou E. M.; Asquith L.; Assamagan K.; Astalos R.; Atkin R. J.; Atkinson M.; Atlay N. 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P.; Becker K.; Becker M.; Becot C.; Beddall A.; Beddall A. J.; Bednyakov V. A.; Bedognetti M.; Bee C. P.; Beermann T. A.; Begalli M.; Begel M.; Behera A.; Behr J. K.; Bellagamba L.; Benchekroun D.; Benekos N.; Benjamin D. P.; Benoit M.; Berger N.; Beringer J.; Berta P.; Bessner M.; Besson N.; Bethani A.; Betti A.; Bevan A. J.; Bianchi R. M.; Biesuz N. V.; Billoud T. R. V.; Bindi M.; Biondi S.; Biswal J. P.; Blue A.; Bogavac D.; Bold T.; Bolz A. E.; Bona M.; Bortfeldt J.; Bosman M.; Bossio Sola J. D.; Bouaouda K.; Bouhova-Thacker E. V.; Boutle S. K.; Boveia A.; Brahimi N.; Brandt A.; Breaden Madden W. D.; Britton D.; Brooijmans G.; Brost E.; Broughton J. H.; Bruckman de Renstrom P. A.; Bruno S.; Bruscino N.; Buckley A. G.; Burdin S.; Burke S.; Buttar C. M.; Butterworth J. M.; Buzykaev A. R.; Cabras G.; Cai H.; Cairo V. M. M.; Cakir O.; Calafiura P.; Calandri A.; Callea G.; Calvente Lopez S.; Calvetti M.; Camarda S.; Camarri P.; Campoverde A.; Canale V.; Cantero J.; Capeans Garrido M. 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A.; Demarco D. A.; Derendarz D.; Dervan P.; Di Bello F. A.; Di Ciaccio A.; Di Ciaccio L.; Diaconu C.; Dias F. A.; Dias Do Vale T.; Dietrich J.; Dittus F.; Djama F.; Djobava T.; Doglioni C.; Doyle A. T.; Duckeck G.; Ducu O. A.; Duda D.; Duperrin A.; Duran Yildiz H.; Durglishvili A.; Dyndal M.; Dziedzic B. S.; Ellert M.; Ellinghaus F.; Ellis N.; Elsing M.; Erdmann J.; Ereditato A.; Escalier M.; Escobar C.; Estrada Pastor O.; Evans H.; Ezhilov A.; Ezzi M.; Fabbri F.; Fabiani V.; Faisca Rodrigues Pereira R. M.; Falke P. J.; Falke S.; Faltova J.; Fanti M.; Farbin A.; Farina E. M.; Farooque T.; Farrington S. M.; Fassi F.; Faucci Giannelli M.; Fawcett W. J.; Feligioni L.; Feng C.; Ferreira de Lima D. E.; Ferrere D.; Filthaut F.; Fiorini L.; Fisher W. C.; Fleck I.; Flores L. M.; Formica A.; Fox H.; Francavilla P.; Franchini M.; Franklin M.; Freund B.; Fullana Torregrosa E.; Gadow P.; Gagnon L. G.; Gamboa Goni R.; García Navarro J. E.; García Pascual J. A.; Gee C. N. P.; Genest M. 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A.; Roloff J.; Romaniouk A.; Romano M.; Rompotis N.; Roos L.; Rosati S.; Rosbach K.; Rotaru M.; Roy D.; Rozen Y.; Rurikova Z.; Russell H. L.; Ryu S.; Ryzhov A.; Sabatini P.; Saimpert M.; Saito M.; Salazar Loyola J. E.; Salvatore D.; Salvucci A.; Sammel D.; Sanchez Pineda A.; Sankey D. P. C.; Santra A.; Sasaki O.; Sato K.; Sauvan E.; Sawyer C.; Schaefer D.; Schildgen L. K.; Schioppa E. J.; Schioppa M.; Schmidt-Sommerfeld K. R.; Schmitt C.; Schmitt S.; Schoeffel L.; Schopf E.; Schouwenberg J. F. P.; Schramm S.; Schwarz T. A.; Sciandra A.; Scornajenghi M.; Scyboz L. M.; Searcy J.; Sebastiani C. D.; Senkin S.; Serkin L.; Sessa M.; Sforza F.; Sfyrla A.; Shabalina E.; Shahinian J. D.; Shaikh N. W.; Shapiro M.; Sharma A. S.; Shi L.; Shimojima M.; Shojaii S.; Simioni E.; Simon M.; Sioli M.; Siral I.; Sliwa K.; Smirnov N.; Smirnov S. Y.; Smirnov Y.; Smirnova L. N.; Smith J. W.; Smolek K.; Smykiewicz A.; Snyder I. M.; Solovyev V.; Sommer P.; Son H.; Song W.; Sopczak A.; Sotiropoulou C. L.; Soualah R.; Sowden B. C.; Spagnolo S.; Spieker T. M.; Stabile A.; Stanecka E.; Stanislaus B.; Stark G. H.; Starovoitov P.; Stärz S.; Staszewski R.; Stevenson T. J.; Stolte P.; Straessner A.; Strandberg J.; Strizenec P.; Stucci S. A.; Stugu B.; Stupak J.; Sullivan M. J.; Sumida T.; Svatos M.; Swiatlowski M.; Sykora I.; Ta D.; Tahirovic E.; Takai H.; Tapia Araya S.; Tartarelli G. F.; Tassi E.; Taylor A. C.; Taylor A. J.; Terashi K.; Terron J.; Terzo S.; Thiele F.; Thompson A. S.; Thomson E.; Tian Y.; Ticse Torres R. E.; Tikhomirov V. O; Tisserant S.; Tokushuku K.; Tomiwa K. G.; Torró Pastor E.; Toth J.; Trigger I. M.; Trincaz-Duvoid S.; Trocmé B.; Trofymov A.; Troncon C.; Trovato F.; Truong L.; Trzebinski M.; Tsai F.; Tsuno S.; Tu Y.; Tudorache A.; Tudorache V.; Turra R.; Tzovara E.; Ughetto M.; Unal G.; Ungaro F. C.; Urquijo P.; Vadla K. O. H.; Vaidya A.; Valente M.; Valero A.; Valéry L.; Van Daalen T. R.; Van Gemmeren P.; Van Vulpen I.; Vanadia M.; Vari R.; Varvell K. E.; Vazquez Furelos D.; Veloso F.; Veneziano S.; Ventura A.; Vercesi V.; Verducci M.; Vermeulen A. T.; Vetterli M. C.; Viaux Maira N.; Vickey T.; Vickey Boeriu O. E.; Villa M.; Vincter M. G.; Vivarelli I.; Vlachos S.; von Buddenbrock S. E.; Vorobel V.; Vos M.; Vranjes N.; Vranjes Milosavljevic M.; Vukotic I.; Walder J.; Walkowiak W.; Wang A. M.; Wang C.; Wanotayaroj C.; Warburton A.; Wardrope D. R.; Watkins P. M.; Watts G.; Weber C.; Weber M. S.; Weber S. A.; Weingarten J.; Weirich M.; Weiser C.; Wenaus T.; Wengler T.; Werner M. D.; Werner P.; Whalen K.; Wickens F. J.; Wielers M.; Wiglesworth C.; Willocq S.; Winkels E.; Winklmeier F.; Winter B. T.; Wolf A.; Wolter M. W.; Wolters H.; Worm S. D.; Woźniak K. W.; Wu M.; Wu S. L.; Wu X.; Xella S.; Xi Z.; Xu D.; Xu H.; Yabsley B.; Yacoob S.; Yamaguchi D.; Yamazaki T.; Yang H. J.; Yang H. T.; Yap Y. C.; Yigitbasi E.; Yorita K.; Yu J.; Zaidan R.; Zakareishvili T.; Zakharchuk N.; Zanzi D.; Zhang D. F.; Zhang D.; Zhang F.; Zhao P.; Zhemchugov A.; Zhou B.; Zhu C. G.; Zoch K.; Zorbas T. G.;We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5
CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 30visibility views 30 download downloads 50 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Heighten Science Publications Corporation Marwan O. Jalambo; Basil Kanoa; Mohammed S. Ellulu; Smaher Younis; Mueen El-Kariri;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.29328/journal.niogb.1001009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United KingdomElsevier BV Authors: Bigger, Brian W.; Begley, David J.; Virgintino, Daniela; Pshezhetsky, Alexey V.;Bigger, Brian W.; Begley, David J.; Virgintino, Daniela; Pshezhetsky, Alexey V.;pmid: 30145178
Mucopolysaccharidosis (MPS) disorders are caused by deficiencies in lysosomal enzymes, leading to impaired glycosaminoglycan (GAG) degradation. The resulting GAG accumulation in cells and connective tissues ultimately results in widespread tissue and organ dysfunction. The seven MPS types currently described are heterogeneous and progressive disorders, with somatic and neurological manifestations depending on the type of accumulating GAG. Heparan sulfate (HS) is one of the GAGs stored in patients with MPS I, II, and VII and the main GAG stored in patients with MPS III. These disorders are associated with significant central nervous system (CNS) abnormalities that can manifest as impaired cognition, hyperactive and/or aggressive behavior, epilepsy, hydrocephalus, and sleeping problems. This review discusses the anatomical and pathophysiological CNS changes accompanying HS accumulation as well as the mechanisms believed to cause CNS abnormalities in MPS patients. The content of this review is based on presentations and discussions on these topics during a meeting on the brain in MPS attended by an international group of MPS experts.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ymgme.2018.08.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu73 citations 73 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ymgme.2018.08.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publication2017Neriman Yilmaz; Robert A. Samson; František Sklenář; Nina Gunde-Cimerman; Jens Frisvad; Monika Coton; Vit Hubka; Cobus M Visagie;Aspergillus section Restricti together with sister section Aspergillus (formerly Eurotium) comprises xerophilic species, that are able to grow on substrates with low water activity and in extreme environments. We adressed the monophyly of both sections within subgenus Aspergillus and applied a multidisciplinary approach for definition of species boundaries in sect. Restricti. The monophyly of sections Aspergillus and Restricti was tested on a set of 102 isolates comprising all currently accepted species and was strongly supported by Maximum likelihood (ML) and Bayesian inferrence (BI) analysis based on β-tubulin (benA), calmodulin (CaM) and RNA polymerase II second largest subunit (RPB2) loci. More than 300 strains belonging to sect. Restricti from various isolation sources and four continents were characterized by DNA sequencing, and 193 isolates were selected for phylogenetic analyses and phenotypic studies. Species delimitation methods based on multispecies coalescent model were employed on DNA sequences from four loci, i.e., ID region of rDNA (ITS + 28S), CaM, benA and RPB2, and supported recognition of 21 species, including 14 new. All these species were also strongly supported in ML and BI analyses. All recognised species can be reliably identified by all four examined genetic loci. Phenotype analysis was performed to support the delimitation of new species and includes colony characteristics on seven cultivation media incubated at several temperatures, growth on an osmotic gradient (six media with NaCl concentration from 0 to 25 %) and analysis of morphology including scanning electron microscopy. The micromorphology of conidial heads, vesicle dimensions, temperature profiles and growth parameters in osmotic gradient were useful criteria for species identification. The vast majority of species in sect. Restricti produce asperglaucide, asperphenamate or both in contrast to species in sect. Aspergillus. Mycophenolic acid was detected for the first time in at least six members of the section. The ascomata of A. halophilicus do not contain auroglaucin, epiheveadride or flavoglaucin which are common in sect. Aspergillus, but shares the echinulins with sect. Aspergillus.
OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu68 citations 68 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 SpainWiley Cortés-Vicente, Elena; Rojas-Garcia, Ricard; Diaz-Manera, Jordi; Querol, Luis; Casasnovas, Carlos; Guerrero-Sola, Antonio; Muñoz-Blanco, José Luis; Bárcena-Llona, José Eulalio; Márquez-Infante, Celedonio; Pardo, Julio; Martínez-Fernández, Eva María; Usón, Mercedes; Oliva-Nacarino, Pedro; Sevilla, Teresa; Illa, Isabel; Universitat Autònoma de Barcelona;doi: 10.1002/acn3.564
handle: 20.500.13003/17162 , 2445/123976 , 10668/12627 , 20.500.12530/36315
pmid: 29928654
pmc: PMC5989782
doi: 10.1002/acn3.564
handle: 20.500.13003/17162 , 2445/123976 , 10668/12627 , 20.500.12530/36315
pmid: 29928654
pmc: PMC5989782
ObjectiveTo evaluate whether the clinical benefit and relapse rates in anti-muscle-specific kinase (MuSK) myasthenia gravis (MG) differ depending on the protocol of rituximab followed. MethodsThis retrospective multicentre study in patients with MuSK MG compared three rituximab protocols in terms of clinical status, relapse, changes in treatment, and adverse side effects. The primary effectiveness endpoint was clinical relapse requiring a further infusion of rituximab. Survival curves were estimated using Kaplan-Meier methods and survival analyses were undertaken using Cox proportional-hazards models. ResultsTwenty-five patients were included: 11 treated with protocol 4 + 2 (375 mg/m(2)/4 weeks, then monthly for 2 months), five treated with protocol 1 + 1 (two 1 g doses 2 weeks apart), and nine treated with protocol 4 (375 mg/m(2)/4 weeks). Mean follow-up was 5.0 years (SD 3.3). Relapse occurred in 18.2%, 80%, and 33.3%, and mean time to relapse was 3.5 (SD 1.5), 1.1 (SD 0.4), and 2.5 (SD 1.4) years, respectively. Based on Kaplan-Meier estimates, patients treated with protocol 4 + 2 had fewer and later relapses than patients treated with the other two protocols (log-rank test P = 0.0001). Patients treated with protocol 1 + 1 had a higher risk of relapse than patients treated with protocol 4 + 2 (HR 112.8, 95% CI, 5.7-2250.4, P = 0.002). Patients treated with protocol 4 showed a trend to a higher risk of relapse than those treated with protocol 4 + 2 (HR 9.2, 95% CI 0.9-91.8, P = 0.059). InterpretationThis study provides class IV evidence that the 4 + 2 rituximab protocol has a lower clinical relapse rate and produces a more durable response than the 1 + 1 and 4 protocols in patients with MuSK MG. I. Illa received research support from the Fondo de Investigacion en Salud, Instituto de Salud Carlos III, Ministry of Health (Spain), FIS PI16/01440 (Fondos FEDER). E. Cortes-Vicente was supported by a FIS grant (CM16/00096) from Fondo de Investigacion en Salud, Instituto de Salud Carlos III, Ministry of Health (Spain) and Fondo Social Europeo.
Diposit Digital de l... arrow_drop_down Diposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAAnnals of Clinical and Translational NeurologyArticle . 2018License: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 77visibility views 77 download downloads 97 Powered bymore_vert Diposit Digital de l... arrow_drop_down Diposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAAnnals of Clinical and Translational NeurologyArticle . 2018License: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/acn3.564&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021International Journal of Sports Physical Therapy Bulow, Alison; Bellemare, Alixandra; Anderson, Judy E; Leiter, Jeff R S; MacDonald, Peter B; Peeler, Jason D;Background Adolescent females are at significant risk for sustaining an ACL injury. The Y-Balance Test (YBT) is frequently used to evaluate neuromuscular control and lower extremity function. However, few studies have quantified 2D lower extremity kinematics during performance of the YBT, and there is an absence of kinematic data specific to at-risk adolescent females. Purpose To examine lower extremity joint kinematics during execution of the YBT by healthy and ACL-injured adolescent females. Study Design Prospective cohort. Methods Twenty-five healthy and ten ACL-injured (mean time from injury 143 days) adolescent females were assessed using the YBT. Sagittal and frontal plane knee and ankle motion was video recorded during execution of the YBT anterior reach movement. Ankle dorsi-flexion, knee flexion, and knee valgus angles were quantified via kinematic analysis. ANOVAs with a post hoc Bonferroni correction were used to compare YBT scoring (%LL) and kinematic data between groups. Pearson product-moment correlations determined the relationship between kinematic data and YBT scoring. Results Healthy and ACL-injured subjects demonstrated similar YBT scores and lower extremity kinematic data. Healthy subjects demonstrated a weak positive correlation between ankle dorsiflexion and YBT scoring, and a weak negative correlation between knee valgus and YBT scoring. These relationships did not exist for ACL-injured subjects. Kinematic data for both groups also demonstrated a large degree of variability, regardless of YBT score. Conclusions Adolescent females frequently utilize a variety of lower extremity movement strategies when performing a functional movement task, and scoring on the YBT offers limited insight regarding lower extremity joint kinematics and ACL-injury risk in a physically active adolescent female population. Level of Evidence Level 3.
International Journa... arrow_drop_down International Journal of Sports Physical TherapyArticleLicense: CC BY ND SAData sources: UnpayWallInternational Journal of Sports Physical TherapyArticle . 2021License: CC BY NC SAData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.26603/001c.21529&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Sports Physical TherapyArticleLicense: CC BY ND SAData sources: UnpayWallInternational Journal of Sports Physical TherapyArticle . 2021License: CC BY NC SAData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.26603/001c.21529&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2021Cold Spring Harbor Laboratory Authors: Maria Skaalum Petersen; Cecilie Bo Hansen; Marnar Fríðheim Kristiansen; Jógvan Páll Fjallsbak; +12 AuthorsMaria Skaalum Petersen; Cecilie Bo Hansen; Marnar Fríðheim Kristiansen; Jógvan Páll Fjallsbak; Sólrun Larsen; Jóhanna Ljósá Hansen; Ida Jarlhelt; Laura Pérez-Alós; Bjarni á Steig; Debes Hammershaimb Christiansen; Lars Fodgaard Møller; Marin Strøm; Guðrið Andorsdóttir; Shahin Gaini; Pal Weihe; Peter Garred;AbstractOnly a few studies have assessed the long-term duration of the humoral immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).In this nationwide longitudinal study from the Faroe Islands with close to full participation of all individuals on the Islands with PCR confirmed COVID-19 during the two waves of infections in the spring and autumn 2020 (n=172 & n=233), samples were drawn at three longitudinal time points (3, 7 and 12 months and 1, 3 and 7 months after disease onset, respectively).Serum was analyzed with a direct quantitative IgG antibody binding ELISA to detect anti–SARS-CoV-2 spike RBD antibodies and a commercially available qualitative sandwich RBD ELISA kit measuring total antibody binding.The seropositive rate in the convalescent individuals was above 95 % at all sampling time points for both assays. There was an overall decline in IgG titers over time in both waves (p < 0.001). Pairwise comparison showed that IgG declined significantly from the first sample until approximately 7 months in both waves (p < 0.001). After that, the antibody level still declined significantly (p < 0.001), but decelerated with an altered slope remaining fairly stable from 7 months to 12 months after infection. Interestingly, the IgG titers followed a U-shaped curve with higher antibody levels among the oldest (67+) and the youngest (0– 17) age groups compared to intermediate groups (p < 0.001).Our results indicate that COVID-19 convalescent individuals are likely to be protected from reinfection up to 12 months after symptom onset and maybe even longer. We believe our results can add to the understanding of natural immunity and the expected durability of SARS-CoV-2 vaccine immune responses.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.04.19.21255720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.04.19.21255720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Spain, Portugal, Sweden, United Kingdom, Sweden, Netherlands, Hungary, Italy, Sweden, Denmark, BelgiumSpringer Science and Business Media LLC NIH | The role of natural selec..., NIH | Pre-Clinical Studies to I..., NIH | Science in a Culture of M... +14 projectsNIH| The role of natural selection in SLE risk among African-Americans ,NIH| Pre-Clinical Studies to Identify SLE Therapeutic Targets ,NIH| Science in a Culture of Mentoring ,NIH| Genomics Core ,NIH| Northwestern University Clinical & Translational Sciences Institute (NUCATS) 2.0 ,NIH| Oklahoma Shared Clinical and Translational Resources ,NIH| TNFAIP3 (A20) and Susceptibility to Systemic Lupus Erythematosus ,NIH| Neuropsychiatric Symptoms and MRI Markers in SLE Patients with APLA ,NIH| Understanding early events in lupus autoimmunity to aid prevention ,NIH| Flow Core ,NIH| CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH ,NIH| Candidate Causal Variants in Systemic Lupus Erythematosus ,NIH| Oklahoma Rheumatic Disease Research Cores Center ,NIH| Lupus Cohort ,NIH| Functional Mechanisms of Causal Variants in Systemic Lupus Erythematosus ,NIH| Genetic and environmental influences on SLE and lupus-related autoimmunity ,NIH| PREVENTION OF CARDIOVASCULAR COMPLICATIONS IN PEDIATRIC SYSTEMIC LUPUS-264022265Authors: Carl D. Langefeld; Hannah C. Ainsworth; Deborah S. Cunninghame Graham; Jennifer A. Kelly; +104 AuthorsCarl D. Langefeld; Hannah C. Ainsworth; Deborah S. Cunninghame Graham; Jennifer A. Kelly; Mary E. Comeau; Miranda C. Marion; Timothy D. Howard; Paula S. Ramos; Jennifer A. Croker; David L. Morris; Johanna K. Sandling; Jonas Carlsson Almlöf; Eduardo Acevedo-Vásquez; Graciela S. Alarcón; Alejandra Babini; Vicente Baca; Anders A. Bengtsson; Guillermo A. Berbotto; Marc Bijl; Elizabeth E. Brown; Hermine I. Brunner; Mario H. Cardiel; Luis J. Catoggio; Ricard Cervera; Jorge M. Cucho-Venegas; Solbritt Rantapää Dahlqvist; Sandra D'Alfonso; Berta Martins da Silva; Iñigo de la Rúa Figueroa; Andrea Doria; Jeffrey C. Edberg; Emőke Endreffy; Jorge A. Esquivel-Valerio; Paul R. Fortin; Barry I. Freedman; Johan Frostegård; Mercedes A. García; Ignacio García-De La Torre; Gary S. Gilkeson; Dafna D. Gladman; Iva Gunnarsson; Joel M. Guthridge; Jennifer Huggins; Judith A. James; Cees G. M. Kallenberg; Diane L. Kamen; David R. Karp; Kenneth M. Kaufman; Leah C. Kottyan; László Kovács; Helle Laustrup; Bernard Lauwerys; Quan Zhen Li; Marco A. Maradiaga-Ceceña; Javier Martín; Joseph M. McCune; David R. McWilliams; Joan T. Merrill; Pedro Miranda; José Francisco Moctezuma; Swapan K. Nath; Timothy B. Niewold; Lorena Orozco; Norberto Ortego-Centeno; Michelle Petri; Christian A. Pineau; Bernardo A. Pons-Estel; Janet E. Pope; Prithvi Raj; Rosalind Ramsey-Goldman; John D. Reveille; Laurie P Russell; José Mario Sabio; Carlos A. Aguilar-Salinas; Hugo R. Scherbarth; Raffaella Scorza; Michael F. Seldin; Christopher Sjöwall; Elisabet Svenungsson; Susan D. Thompson; Sergio Toloza; Lennart Truedsson; Teresa Tusié-Luna; Carlos Vasconcelos; Luis M. Vilá; Daniel J. Wallace; Michael H. Weisman; Joan E. Wither; Tushar Bhangale; Jorge R. Oksenberg; John D. Rioux; Peter K. Gregersen; Ann-Christine Syvänen; Lars Rönnblom; Lindsey A. Criswell; Chaim O. Jacob; Kathy L. Sivils; Betty P. Tsao; Laura E. Schanberg; Timothy W. Behrens; Earl D. Silverman; Marta E. Alarcón-Riquelme; Robert P. Kimberly; John B. Harley; Edward K. Wakeland; Robert R. Graham; Patrick M. Gaffney; Timothy J. Vyse;doi: 10.1038/ncomms16021
handle: 2445/123026 , 11577/3241664 , 11370/dd99ef90-bc94-4f3e-b155-83d753352187 , 10668/11414 , 10400.16/2231 , 2078.1/202946
pmid: 28714469
pmc: PMC5520018
doi: 10.1038/ncomms16021
handle: 2445/123026 , 11577/3241664 , 11370/dd99ef90-bc94-4f3e-b155-83d753352187 , 10668/11414 , 10400.16/2231 , 2078.1/202946
pmid: 28714469
pmc: PMC5520018
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P amp;lt; 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE. Funding Agencies|Alliance for Lupus Research; Arthritis Research UK Special Strategic Award [19289]; George Koukis; National Institute for Health Research (NIHR) Biomedical Research Centre based at Guys and St Thomas NHS Foundation Trust; Kings College London; NIH [AR049084]; International Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN) [AI083194, CA141700, AR058621]; Proyecto de Excelencia; Consejeria de Andalucia; MUSC [UL1RR029882, 5P60AR062755]; US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (NIH) [K01 AR067280, P60 AR062755, N01AR22265]; APPLE Investigators; NIAMS/NIH [P50-AR055503]; RILITE foundation; Genentech; [AR043814]; [AR-065626]; [AR060366]; [MD007909]; [AI107176]; [AR-057172]; [RC2 AR058959]; [U19 A1082714]; [R01 AR063124]; [P30 GM110766]; [R01 AR056360]; [P60 AR053308]; [R01AR43727]; [NIH AR 043727]; [069572]
LAReferencia - Red F... arrow_drop_down University of Southern Denmark Research OutputArticle . 2017Data sources: University of Southern Denmark Research OutputRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2017License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017License: CC BYRepositório Científico do Centro Hospitalar do PortoArticle . 2017Data sources: Repositório Científico do Centro Hospitalar do Portoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu290 citations 290 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 222visibility views 222 download downloads 222 Powered bymore_vert LAReferencia - Red F... arrow_drop_down University of Southern Denmark Research OutputArticle . 2017Data sources: University of Southern Denmark Research OutputRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2017License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017License: CC BYRepositório Científico do Centro Hospitalar do PortoArticle . 2017Data sources: Repositório Científico do Centro Hospitalar do Portoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 SwedenMDPI AG Authors: Alessio Squassina; Claudia Pisanu; Roberta Vanni;Alessio Squassina; Claudia Pisanu; Roberta Vanni;Mood disorders are associated with an increased risk of aging-related diseases, which greatly contribute to the excess morbidity and mortality observed in affected individuals. Clinical and molecular findings also suggest that mood disorders might be characterized by a permanent state of low-grade inflammation. At the cellular level, aging translates into telomeres shortening. Intriguingly, inflammation and telomere shortening show a bidirectional association: a pro-inflammatory state seems to contribute to aging and telomere dysfunction, and telomere attrition is able to induce low-grade inflammation. Several independent studies have reported shorter telomere length and increased levels of circulating inflammatory cytokines in mood disorders, suggesting a complex interplay between altered inflammatory–immune responses and telomere dynamics in the etiopathogenesis of these disorders. In this review, we critically discuss studies investigating the role of telomere attrition and inflammation in the pathogenesis and course of mood disorders, and in pharmacological treatments with psychotropic medications.
Europe PubMed Centra... arrow_drop_down Publikationer från Uppsala Universitet; Digitala Vetenskapliga Arkivet - Academic Archive On-lineOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu42 citations 42 popularity Top 10% influence Average impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Publikationer från Uppsala Universitet; Digitala Vetenskapliga Arkivet - Academic Archive On-lineOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Italy, SwitzerlandAmerican Medical Association (AMA) NIH | Collaborative Genetic Stu..., NIH | A COLLABORATIVE GENOMIC S..., NIH | A Collaborative Genomic S... +9 projectsNIH| Collaborative Genetic Study of Bipolar Disorder ,NIH| A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER ,NIH| A Collaborative Genomic Study of Bipolar Disorder ,NIH| Human Genetics of Addiction: A Study of Common and Specific Factors ,NIH| Collaborative Genomic Study of Bipolar Disorder ,NIH| COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER ,NIH| A Collaborative Genomic Study of Bipolar Disorder ,SNSF| NCCR SYNAPSY: The synaptic bases of mental diseases (phase II) ,NIH| A Collaborative Genomic Study of Bipolar Disorder ,NIH| A Collaborative Genomic Study of Bipolar Disoder ,CIHR ,NIH| Mapping Genes for Mood and Anxiety DisordersAzmeraw T. Amare; Klaus Oliver Schubert; Liping Hou; Scott R. Clark; Sergi Papiol; Urs Heilbronner; Franziska Degenhardt; Fasil Tekola-Ayele; Yi-Hsiang Hsu; Tatyana Shekhtman; Mazda Adli; Nirmala Akula; Kazufumi Akiyama; Raffaella Ardau; Bárbara Arias; Jean-Michel Aubry; Lena Backlund; Abesh Kumar Bhattacharjee; Frank Bellivier; Antonio Benabarre; Susanne Bengesser; Joanna M. Biernacka; Armin Birner; Clara Brichant-Petitjean; Pablo Cervantes; Hsi-Chung Chen; Caterina Chillotti; Sven Cichon; Cristiana Cruceanu; Piotr M. Czerski; Nina Dalkner; Alexandre Dayer; Maria Del Zompo; J. Raymond DePaulo; Bruno Etain; Peter Falkai; Andreas J. Forstner; Louise Frisén; Mark A. Frye; Janice M. Fullerton; Sébastien Gard; Julie Garnham; Fernando S. Goes; Maria Grigoroiu-Serbanescu; Paul Grof; Ryota Hashimoto; Joanna Hauser; Stefan Herms; Per Hoffmann; Andrea Hofmann; Stéphane Jamain; Esther Jiménez; Jean-Pierre Kahn; Layla Kassem; Po-Hsiu Kuo; Tadafumi Kato; John R. Kelsoe; Sarah Kittel-Schneider; Sebastian Kliwicki; Barbara König; Ichiro Kusumi; Gonzalo Laje; Mikael Landén; Catharina Lavebratt; Marion Leboyer; Susan G. Leckband; Alfonso Tortorella; Mirko Manchia; Lina Martinsson; Michael McCarthy; Susan L. McElroy; Francesc Colom; Marina Mitjans; Francis M. Mondimore; Palmiero Monteleone; Caroline M. Nievergelt; Markus M. Nöthen; Tomas Novak; Claire O'Donovan; Norio Ozaki; Urban Ösby; Andrea Pfennig; James B. Potash; Andreas Reif; Eva Z. Reininghaus; Guy A. Rouleau; Janusz K. Rybakowski; Martin Schalling; Peter R. Schofield; Barbara W. Schweizer; Giovanni Severino; Paul D. Shilling; Katzutaka Shimoda; Christian Simhandl; Claire Slaney; Alessio Squassina; Thomas Stamm; Pavla Stopkova; Mario Maj; Gustavo Turecki; Eduard Vieta; Julia Volkert; Stephanie H. Witt; Adam Wright; Peter P. Zandi; Philip B. Mitchell; Michael Bauer; Martin Alda; Marcella Rietschel; Francis J. McMahon; Thomas G. Schulze; Bernhard T. Baune;IMPORTANCE Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ). OBJECTIVES To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association. DESIGN, SETTING, AND PARTICIPANTS A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013.Weighted SCZ polygenic scores were computed at different P value thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36 989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017. MAIN OUTCOMES AND MEASURES Treatment response to lithiumwas defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained. RESULTS Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a threshold P < 5 ? 10-2. Patients with BPAD who had a low polygenic load for SCZ responded better to lithium, with odds ratios for lithium response ranging from 3.46 (95%CI, 1.42-8.41) at the first decile to 2.03 (95%CI, 0.86-4.81) at the ninth decile, compared with the patients in the 10th decile of SCZ risk. In the cross-trait meta-GWAS, 15 genetic loci that may have overlapping effects on lithium treatment response and susceptibility to SCZ were identified. Functional pathway and network analysis of these loci point to the HLA antigen complex and inflammatory cytokines. CONCLUSIONS AND RELEVANCE This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.
JAMA Psychiatry arrow_drop_down Archivio della Ricerca - Università di SalernoArticle . 2018Data sources: Archivio della Ricerca - Università di Salernoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu109 citations 109 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert JAMA Psychiatry arrow_drop_down Archivio della Ricerca - Università di SalernoArticle . 2018Data sources: Archivio della Ricerca - Università di Salernoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Report , Other literature type , Preprint 2018 Turkey, Italy, Italy, Germany, Portugal, Portugal, Italy, United Kingdom, Italy, Italy, Spain, Denmark, Italy, Poland, Italy, Italy, France, ItalySpringer Science and Business Media LLC Aaboud M.; Aad G.; Abbott B.; Abdinov O.; Abeloos B.; Abhayasinghe D. K.; Abidi S. H.; Abouzeid O. S.; Abraham N. L.; Abramowicz H.; Abreu H.; Abulaiti Y.; Acharya B. S.; Adachi S.; Adam L.; Adamczyk L.; Adelman J.; Adersberger M.; Adiguzel A.; Adye T.; Affolder A. A.; Afik Y.; Agheorghiesei C.; Aguilar-Saavedra J. A.; Ahmadov F.; Aielli G.; Akatsuka S.; Åkesson T. P. A.; Akilli E.; Akimov A. V.; Alberghi G. L.; Albert J.; Albicocco P.; Alconada Verzini M. J.; Alderweireldt S.; Aleksa M.; Aleksandrov I. N.; Alexa C.; Alexopoulos T.; Alhroob M.; Ali B.; Alimonti G.; Alison J.; Alkire S. P.; Allaire C.; Allbrooke B. M. M.; Allen B. W.; Allport P. P.; Aloisio A.; Alonso A.; Alonso F.; Alpigiani C.; Alshehri A. A.; Alstaty M. I.; Alvarez Gonzalez B.; Álvarez Piqueras D.; Alviggi M. G.; Amadio B. T.; Amaral Coutinho Y.; Ambler A.; Ambroz L.; Amelung C.; Amidei D.; Amor Dos Santos S. P.; Amoroso S.; Amrouche C. S.; Anastopoulos C.; Ancu L. S.; Andari N.; Andeen T.; Anders C. F.; Anders J. K.; Anderson K. J.; Andreazza A.; Andrei V.; Anelli C. R.; Angelidakis S.; Angelozzi I.; Angerami A.; Anisenkov A. V.; Annovi A.; Antel C.; Anthony M. T.; Antonelli M.; Antrim D. J. A.; Anulli F.; Aoki M.; Aparisi Pozo J. A.; Aperio Bella L.; Arabidze G.; Araque J. P.; Araujo Ferraz V.; Araujo Pereira R.; Arce A. T. H.; Ardell R. E.; Arduh F. A.; Arguin J. -F.; Argyropoulos S.; Armbruster A. J.; Armitage L. J.; Armstrong A.; Arnaez O.; Arnold H.; Arratia M.; Arslan O.; Artamonov A.; Artoni G.; Artz S.; Asai S.; Asbah N.; Asimakopoulou E. M.; Asquith L.; Assamagan K.; Astalos R.; Atkin R. J.; Atkinson M.; Atlay N. 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U. E.; Oreglia M. J.; Orestano D.; Orlando N.; Ould-Saada F.; Ozturk N.; Pachal K.; Pacheco Pages A.; Padilla Aranda C.; Palestini S.; Palka M.; Panduro Vazquez J. G.; Panizzo G.; Pasuwan P.; Pathak A.; Pedro R.; Peleganchuk S. V.; Penc O.; Perini L.; Peters K.; Petersen B. A.; Petrucci F.; Pezoa R.; Pham T.; Pianori E.; Pilkington A. D.; Pleskot V.; Poggi R.; Policicchio A.; Pollard C. S.; Ponomarenko D.; Potter C. J.; Potti H.; Poulsen T.; Poveda J.; Pralavorio P.; Primavera M.; Prince S.; Proklova N.; Prokoshin F.; Przybycien M.; Puri A.; Qian J.; Queitsch-Maitland M.; Ragusa F.; Raine J. A.; Rauch D. M.; Ravina B.; Reale M.; Rebuzzi D. M.; Redlinger G.; Reeves K.; Reichert J.; Resconi S.; Resseguie E. D.; Ricci E.; Ridel M.; Rieck P.; Rifki O.; Rimoldi A.; Ripellino G.; Rivera Vergara J. C.; Roberts R. T.; Robinson D.; Robson A.; Rocco E.; Roda C.; Rodriguez Bosca S.; Rodriguez Perez A.; Roland C. P. A.; Roloff J.; Romaniouk A.; Romano M.; Rompotis N.; Roos L.; Rosati S.; Rosbach K.; Rotaru M.; Roy D.; Rozen Y.; Rurikova Z.; Russell H. L.; Ryu S.; Ryzhov A.; Sabatini P.; Saimpert M.; Saito M.; Salazar Loyola J. E.; Salvatore D.; Salvucci A.; Sammel D.; Sanchez Pineda A.; Sankey D. P. C.; Santra A.; Sasaki O.; Sato K.; Sauvan E.; Sawyer C.; Schaefer D.; Schildgen L. K.; Schioppa E. J.; Schioppa M.; Schmidt-Sommerfeld K. R.; Schmitt C.; Schmitt S.; Schoeffel L.; Schopf E.; Schouwenberg J. F. P.; Schramm S.; Schwarz T. A.; Sciandra A.; Scornajenghi M.; Scyboz L. M.; Searcy J.; Sebastiani C. D.; Senkin S.; Serkin L.; Sessa M.; Sforza F.; Sfyrla A.; Shabalina E.; Shahinian J. D.; Shaikh N. W.; Shapiro M.; Sharma A. S.; Shi L.; Shimojima M.; Shojaii S.; Simioni E.; Simon M.; Sioli M.; Siral I.; Sliwa K.; Smirnov N.; Smirnov S. Y.; Smirnov Y.; Smirnova L. N.; Smith J. W.; Smolek K.; Smykiewicz A.; Snyder I. M.; Solovyev V.; Sommer P.; Son H.; Song W.; Sopczak A.; Sotiropoulou C. L.; Soualah R.; Sowden B. C.; Spagnolo S.; Spieker T. M.; Stabile A.; Stanecka E.; Stanislaus B.; Stark G. H.; Starovoitov P.; Stärz S.; Staszewski R.; Stevenson T. J.; Stolte P.; Straessner A.; Strandberg J.; Strizenec P.; Stucci S. A.; Stugu B.; Stupak J.; Sullivan M. J.; Sumida T.; Svatos M.; Swiatlowski M.; Sykora I.; Ta D.; Tahirovic E.; Takai H.; Tapia Araya S.; Tartarelli G. F.; Tassi E.; Taylor A. C.; Taylor A. J.; Terashi K.; Terron J.; Terzo S.; Thiele F.; Thompson A. S.; Thomson E.; Tian Y.; Ticse Torres R. E.; Tikhomirov V. O; Tisserant S.; Tokushuku K.; Tomiwa K. G.; Torró Pastor E.; Toth J.; Trigger I. M.; Trincaz-Duvoid S.; Trocmé B.; Trofymov A.; Troncon C.; Trovato F.; Truong L.; Trzebinski M.; Tsai F.; Tsuno S.; Tu Y.; Tudorache A.; Tudorache V.; Turra R.; Tzovara E.; Ughetto M.; Unal G.; Ungaro F. C.; Urquijo P.; Vadla K. O. H.; Vaidya A.; Valente M.; Valero A.; Valéry L.; Van Daalen T. R.; Van Gemmeren P.; Van Vulpen I.; Vanadia M.; Vari R.; Varvell K. E.; Vazquez Furelos D.; Veloso F.; Veneziano S.; Ventura A.; Vercesi V.; Verducci M.; Vermeulen A. T.; Vetterli M. C.; Viaux Maira N.; Vickey T.; Vickey Boeriu O. E.; Villa M.; Vincter M. G.; Vivarelli I.; Vlachos S.; von Buddenbrock S. E.; Vorobel V.; Vos M.; Vranjes N.; Vranjes Milosavljevic M.; Vukotic I.; Walder J.; Walkowiak W.; Wang A. M.; Wang C.; Wanotayaroj C.; Warburton A.; Wardrope D. R.; Watkins P. M.; Watts G.; Weber C.; Weber M. S.; Weber S. A.; Weingarten J.; Weirich M.; Weiser C.; Wenaus T.; Wengler T.; Werner M. D.; Werner P.; Whalen K.; Wickens F. J.; Wielers M.; Wiglesworth C.; Willocq S.; Winkels E.; Winklmeier F.; Winter B. T.; Wolf A.; Wolter M. W.; Wolters H.; Worm S. D.; Woźniak K. W.; Wu M.; Wu S. L.; Wu X.; Xella S.; Xi Z.; Xu D.; Xu H.; Yabsley B.; Yacoob S.; Yamaguchi D.; Yamazaki T.; Yang H. J.; Yang H. T.; Yap Y. C.; Yigitbasi E.; Yorita K.; Yu J.; Zaidan R.; Zakareishvili T.; Zakharchuk N.; Zanzi D.; Zhang D. F.; Zhang D.; Zhang F.; Zhao P.; Zhemchugov A.; Zhou B.; Zhu C. G.; Zoch K.; Zorbas T. G.;We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5
CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 30visibility views 30 download downloads 50 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Heighten Science Publications Corporation Marwan O. Jalambo; Basil Kanoa; Mohammed S. Ellulu; Smaher Younis; Mueen El-Kariri;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United KingdomElsevier BV Authors: Bigger, Brian W.; Begley, David J.; Virgintino, Daniela; Pshezhetsky, Alexey V.;Bigger, Brian W.; Begley, David J.; Virgintino, Daniela; Pshezhetsky, Alexey V.;pmid: 30145178
Mucopolysaccharidosis (MPS) disorders are caused by deficiencies in lysosomal enzymes, leading to impaired glycosaminoglycan (GAG) degradation. The resulting GAG accumulation in cells and connective tissues ultimately results in widespread tissue and organ dysfunction. The seven MPS types currently described are heterogeneous and progressive disorders, with somatic and neurological manifestations depending on the type of accumulating GAG. Heparan sulfate (HS) is one of the GAGs stored in patients with MPS I, II, and VII and the main GAG stored in patients with MPS III. These disorders are associated with significant central nervous system (CNS) abnormalities that can manifest as impaired cognition, hyperactive and/or aggressive behavior, epilepsy, hydrocephalus, and sleeping problems. This review discusses the anatomical and pathophysiological CNS changes accompanying HS accumulation as well as the mechanisms believed to cause CNS abnormalities in MPS patients. The content of this review is based on presentations and discussions on these topics during a meeting on the brain in MPS attended by an international group of MPS experts.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu73 citations 73 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publication2017Neriman Yilmaz; Robert A. Samson; František Sklenář; Nina Gunde-Cimerman; Jens Frisvad; Monika Coton; Vit Hubka; Cobus M Visagie;Aspergillus section Restricti together with sister section Aspergillus (formerly Eurotium) comprises xerophilic species, that are able to grow on substrates with low water activity and in extreme environments. We adressed the monophyly of both sections within subgenus Aspergillus and applied a multidisciplinary approach for definition of species boundaries in sect. Restricti. The monophyly of sections Aspergillus and Restricti was tested on a set of 102 isolates comprising all currently accepted species and was strongly supported by Maximum likelihood (ML) and Bayesian inferrence (BI) analysis based on β-tubulin (benA), calmodulin (CaM) and RNA polymerase II second largest subunit (RPB2) loci. More than 300 strains belonging to sect. Restricti from various isolation sources and four continents were characterized by DNA sequencing, and 193 isolates were selected for phylogenetic analyses and phenotypic studies. Species delimitation methods based on multispecies coalescent model were employed on DNA sequences from four loci, i.e., ID region of rDNA (ITS + 28S), CaM, benA and RPB2, and supported recognition of 21 species, including 14 new. All these species were also strongly supported in ML and BI analyses. All recognised species can be reliably identified by all four examined genetic loci. Phenotype analysis was performed to support the delimitation of new species and includes colony characteristics on seven cultivation media incubated at several temperatures, growth on an osmotic gradient (six media with NaCl concentration from 0 to 25 %) and analysis of morphology including scanning electron microscopy. The micromorphology of conidial heads, vesicle dimensions, temperature profiles and growth parameters in osmotic gradient were useful criteria for species identification. The vast majority of species in sect. Restricti produce asperglaucide, asperphenamate or both in contrast to species in sect. Aspergillus. Mycophenolic acid was detected for the first time in at least six members of the section. The ascomata of A. halophilicus do not contain auroglaucin, epiheveadride or flavoglaucin which are common in sect. Aspergillus, but shares the echinulins with sect. Aspergillus.
OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu68 citations 68 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 SpainWiley Cortés-Vicente, Elena; Rojas-Garcia, Ricard; Diaz-Manera, Jordi; Querol, Luis; Casasnovas, Carlos; Guerrero-Sola, Antonio; Muñoz-Blanco, José Luis; Bárcena-Llona, José Eulalio; Márquez-Infante, Celedonio; Pardo, Julio; Martínez-Fernández, Eva María; Usón, Mercedes; Oliva-Nacarino, Pedro; Sevilla, Teresa; Illa, Isabel; Universitat Autònoma de Barcelona;doi: 10.1002/acn3.564
handle: 20.500.13003/17162 , 2445/123976 , 10668/12627 , 20.500.12530/36315
pmid: 29928654
pmc: PMC5989782
doi: 10.1002/acn3.564
handle: 20.500.13003/17162 , 2445/123976 , 10668/12627 , 20.500.12530/36315
pmid: 29928654
pmc: PMC5989782
ObjectiveTo evaluate whether the clinical benefit and relapse rates in anti-muscle-specific kinase (MuSK) myasthenia gravis (MG) differ depending on the protocol of rituximab followed. MethodsThis retrospective multicentre study in patients with MuSK MG compared three rituximab protocols in terms of clinical status, relapse, changes in treatment, and adverse side effects. The primary effectiveness endpoint was clinical relapse requiring a further infusion of rituximab. Survival curves were estimated using Kaplan-Meier methods and survival analyses were undertaken using Cox proportional-hazards models. ResultsTwenty-five patients were included: 11 treated with protocol 4 + 2 (375 mg/m(2)/4 weeks, then monthly for 2 months), five treated with protocol 1 + 1 (two 1 g doses 2 weeks apart), and nine treated with protocol 4 (375 mg/m(2)/4 weeks). Mean follow-up was 5.0 years (SD 3.3). Relapse occurred in 18.2%, 80%, and 33.3%, and mean time to relapse was 3.5 (SD 1.5), 1.1 (SD 0.4), and 2.5 (SD 1.4) years, respectively. Based on Kaplan-Meier estimates, patients treated with protocol 4 + 2 had fewer and later relapses than patients treated with the other two protocols (log-rank test P = 0.0001). Patients treated with protocol 1 + 1 had a higher risk of relapse than patients treated with protocol 4 + 2 (HR 112.8, 95% CI, 5.7-2250.4, P = 0.002). Patients treated with protocol 4 showed a trend to a higher risk of relapse than those treated with protocol 4 + 2 (HR 9.2, 95% CI 0.9-91.8, P = 0.059). InterpretationThis study provides class IV evidence that the 4 + 2 rituximab protocol has a lower clinical relapse rate and produces a more durable response than the 1 + 1 and 4 protocols in patients with MuSK MG. I. Illa received research support from the Fondo de Investigacion en Salud, Instituto de Salud Carlos III, Ministry of Health (Spain), FIS PI16/01440 (Fondos FEDER). E. Cortes-Vicente was supported by a FIS grant (CM16/00096) from Fondo de Investigacion en Salud, Instituto de Salud Carlos III, Ministry of Health (Spain) and Fondo Social Europeo.
Diposit Digital de l... arrow_drop_down Diposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAAnnals of Clinical and Translational NeurologyArticle . 2018License: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 77visibility views 77 download downloads 97 Powered bymore_vert Diposit Digital de l... arrow_drop_down Diposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BY NC NDRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAAnnals of Clinical and Translational NeurologyArticle . 2018License: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021International Journal of Sports Physical Therapy Bulow, Alison; Bellemare, Alixandra; Anderson, Judy E; Leiter, Jeff R S; MacDonald, Peter B; Peeler, Jason D;Background Adolescent females are at significant risk for sustaining an ACL injury. The Y-Balance Test (YBT) is frequently used to evaluate neuromuscular control and lower extremity function. However, few studies have quantified 2D lower extremity kinematics during performance of the YBT, and there is an absence of kinematic data specific to at-risk adolescent females. Purpose To examine lower extremity joint kinematics during execution of the YBT by healthy and ACL-injured adolescent females. Study Design Prospective cohort. Methods Twenty-five healthy and ten ACL-injured (mean time from injury 143 days) adolescent females were assessed using the YBT. Sagittal and frontal plane knee and ankle motion was video recorded during execution of the YBT anterior reach movement. Ankle dorsi-flexion, knee flexion, and knee valgus angles were quantified via kinematic analysis. ANOVAs with a post hoc Bonferroni correction were used to compare YBT scoring (%LL) and kinematic data between groups. Pearson product-moment correlations determined the relationship between kinematic data and YBT scoring. Results Healthy and ACL-injured subjects demonstrated similar YBT scores and lower extremity kinematic data. Healthy subjects demonstrated a weak positive correlation between ankle dorsiflexion and YBT scoring, and a weak negative correlation between knee valgus and YBT scoring. These relationships did not exist for ACL-injured subjects. Kinematic data for both groups also demonstrated a large degree of variability, regardless of YBT score. Conclusions Adolescent females frequently utilize a variety of lower extremity movement strategies when performing a functional movement task, and scoring on the YBT offers limited insight regarding lower extremity joint kinematics and ACL-injury risk in a physically active adolescent female population. Level of Evidence Level 3.
International Journa... arrow_drop_down International Journal of Sports Physical TherapyArticleLicense: CC BY ND SAData sources: UnpayWallInternational Journal of Sports Physical TherapyArticle . 2021License: CC BY NC SAData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Sports Physical TherapyArticleLicense: CC BY ND SAData sources: UnpayWallInternational Journal of Sports Physical TherapyArticle . 2021License: CC BY NC SAData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2021Cold Spring Harbor Laboratory Authors: Maria Skaalum Petersen; Cecilie Bo Hansen; Marnar Fríðheim Kristiansen; Jógvan Páll Fjallsbak; +12 AuthorsMaria Skaalum Petersen; Cecilie Bo Hansen; Marnar Fríðheim Kristiansen; Jógvan Páll Fjallsbak; Sólrun Larsen; Jóhanna Ljósá Hansen; Ida Jarlhelt; Laura Pérez-Alós; Bjarni á Steig; Debes Hammershaimb Christiansen; Lars Fodgaard Møller; Marin Strøm; Guðrið Andorsdóttir; Shahin Gaini; Pal Weihe; Peter Garred;AbstractOnly a few studies have assessed the long-term duration of the humoral immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).In this nationwide longitudinal study from the Faroe Islands with close to full participation of all individuals on the Islands with PCR confirmed COVID-19 during the two waves of infections in the spring and autumn 2020 (n=172 & n=233), samples were drawn at three longitudinal time points (3, 7 and 12 months and 1, 3 and 7 months after disease onset, respectively).Serum was analyzed with a direct quantitative IgG antibody binding ELISA to detect anti–SARS-CoV-2 spike RBD antibodies and a commercially available qualitative sandwich RBD ELISA kit measuring total antibody binding.The seropositive rate in the convalescent individuals was above 95 % at all sampling time points for both assays. There was an overall decline in IgG titers over time in both waves (p < 0.001). Pairwise comparison showed that IgG declined significantly from the first sample until approximately 7 months in both waves (p < 0.001). After that, the antibody level still declined significantly (p < 0.001), but decelerated with an altered slope remaining fairly stable from 7 months to 12 months after infection. Interestingly, the IgG titers followed a U-shaped curve with higher antibody levels among the oldest (67+) and the youngest (0– 17) age groups compared to intermediate groups (p < 0.001).Our results indicate that COVID-19 convalescent individuals are likely to be protected from reinfection up to 12 months after symptom onset and maybe even longer. We believe our results can add to the understanding of natural immunity and the expected durability of SARS-CoV-2 vaccine immune responses.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Spain, Portugal, Sweden, United Kingdom, Sweden, Netherlands, Hungary, Italy, Sweden, Denmark, BelgiumSpringer Science and Business Media LLC NIH | The role of natural selec..., NIH | Pre-Clinical Studies to I..., NIH | Science in a Culture of M... +14 projectsNIH| The role of natural selection in SLE risk among African-Americans ,NIH| Pre-Clinical Studies to Identify SLE Therapeutic Targets ,NIH| Science in a Culture of Mentoring ,NIH| Genomics Core ,NIH| Northwestern University Clinical & Translational Sciences Institute (NUCATS) 2.0 ,NIH| Oklahoma Shared Clinical and Translational Resources ,NIH| TNFAIP3 (A20) and Susceptibility to Systemic Lupus Erythematosus ,NIH| Neuropsychiatric Symptoms and MRI Markers in SLE Patients with APLA ,NIH| Understanding early events in lupus autoimmunity to aid prevention ,NIH| Flow Core ,NIH| CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH ,NIH| Candidate Causal Variants in Systemic Lupus Erythematosus ,NIH| Oklahoma Rheumatic Disease Research Cores Center ,NIH| Lupus Cohort ,NIH| Functional Mechanisms of Causal Variants in Systemic Lupus Erythematosus ,NIH| Genetic and environmental influences on SLE and lupus-related autoimmunity ,NIH| PREVENTION OF CARDIOVASCULAR COMPLICATIONS IN PEDIATRIC SYSTEMIC LUPUS-264022265Authors: Carl D. Langefeld; Hannah C. Ainsworth; Deborah S. Cunninghame Graham; Jennifer A. Kelly; +104 AuthorsCarl D. Langefeld; Hannah C. Ainsworth; Deborah S. Cunninghame Graham; Jennifer A. Kelly; Mary E. Comeau; Miranda C. Marion; Timothy D. Howard; Paula S. Ramos; Jennifer A. Croker; David L. Morris; Johanna K. Sandling; Jonas Carlsson Almlöf; Eduardo Acevedo-Vásquez; Graciela S. Alarcón; Alejandra Babini; Vicente Baca; Anders A. Bengtsson; Guillermo A. Berbotto; Marc Bijl; Elizabeth E. Brown; Hermine I. Brunner; Mario H. Cardiel; Luis J. Catoggio; Ricard Cervera; Jorge M. Cucho-Venegas; Solbritt Rantapää Dahlqvist; Sandra D'Alfonso; Berta Martins da Silva; Iñigo de la Rúa Figueroa; Andrea Doria; Jeffrey C. Edberg; Emőke Endreffy; Jorge A. Esquivel-Valerio; Paul R. Fortin; Barry I. Freedman; Johan Frostegård; Mercedes A. García; Ignacio García-De La Torre; Gary S. Gilkeson; Dafna D. Gladman; Iva Gunnarsson; Joel M. Guthridge; Jennifer Huggins; Judith A. James; Cees G. M. Kallenberg; Diane L. Kamen; David R. Karp; Kenneth M. Kaufman; Leah C. Kottyan; László Kovács; Helle Laustrup; Bernard Lauwerys; Quan Zhen Li; Marco A. Maradiaga-Ceceña; Javier Martín; Joseph M. McCune; David R. McWilliams; Joan T. Merrill; Pedro Miranda; José Francisco Moctezuma; Swapan K. Nath; Timothy B. Niewold; Lorena Orozco; Norberto Ortego-Centeno; Michelle Petri; Christian A. Pineau; Bernardo A. Pons-Estel; Janet E. Pope; Prithvi Raj; Rosalind Ramsey-Goldman; John D. Reveille; Laurie P Russell; José Mario Sabio; Carlos A. Aguilar-Salinas; Hugo R. Scherbarth; Raffaella Scorza; Michael F. Seldin; Christopher Sjöwall; Elisabet Svenungsson; Susan D. Thompson; Sergio Toloza; Lennart Truedsson; Teresa Tusié-Luna; Carlos Vasconcelos; Luis M. Vilá; Daniel J. Wallace; Michael H. Weisman; Joan E. Wither; Tushar Bhangale; Jorge R. Oksenberg; John D. Rioux; Peter K. Gregersen; Ann-Christine Syvänen; Lars Rönnblom; Lindsey A. Criswell; Chaim O. Jacob; Kathy L. Sivils; Betty P. Tsao; Laura E. Schanberg; Timothy W. Behrens; Earl D. Silverman; Marta E. Alarcón-Riquelme; Robert P. Kimberly; John B. Harley; Edward K. Wakeland; Robert R. Graham; Patrick M. Gaffney; Timothy J. Vyse;doi: 10.1038/ncomms16021
handle: 2445/123026 , 11577/3241664 , 11370/dd99ef90-bc94-4f3e-b155-83d753352187 , 10668/11414 , 10400.16/2231 , 2078.1/202946
pmid: 28714469
pmc: PMC5520018
doi: 10.1038/ncomms16021
handle: 2445/123026 , 11577/3241664 , 11370/dd99ef90-bc94-4f3e-b155-83d753352187 , 10668/11414 , 10400.16/2231 , 2078.1/202946
pmid: 28714469
pmc: PMC5520018
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P amp;lt; 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE. Funding Agencies|Alliance for Lupus Research; Arthritis Research UK Special Strategic Award [19289]; George Koukis; National Institute for Health Research (NIHR) Biomedical Research Centre based at Guys and St Thomas NHS Foundation Trust; Kings College London; NIH [AR049084]; International Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN) [AI083194, CA141700, AR058621]; Proyecto de Excelencia; Consejeria de Andalucia; MUSC [UL1RR029882, 5P60AR062755]; US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (NIH) [K01 AR067280, P60 AR062755, N01AR22265]; APPLE Investigators; NIAMS/NIH [P50-AR055503]; RILITE foundation; Genentech; [AR043814]; [AR-065626]; [AR060366]; [MD007909]; [AI107176]; [AR-057172]; [RC2 AR058959]; [U19 A1082714]; [R01 AR063124]; [P30 GM110766]; [R01 AR056360]; [P60 AR053308]; [R01AR43727]; [NIH AR 043727]; [069572]
LAReferencia - Red F... arrow_drop_down University of Southern Denmark Research OutputArticle . 2017Data sources: University of Southern Denmark Research OutputRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2017License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017License: CC BYRepositório Científico do Centro Hospitalar do PortoArticle . 2017Data sources: Repositório Científico do Centro Hospitalar do Portoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu290 citations 290 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 222visibility views 222 download downloads 222 Powered bymore_vert LAReferencia - Red F... arrow_drop_down University of Southern Denmark Research OutputArticle . 2017Data sources: University of Southern Denmark Research OutputRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2017License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2017License: CC BYRepositório Científico do Centro Hospitalar do PortoArticle . 2017Data sources: Repositório Científico do Centro Hospitalar do Portoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 SwedenMDPI AG Authors: Alessio Squassina; Claudia Pisanu; Roberta Vanni;Alessio Squassina; Claudia Pisanu; Roberta Vanni;Mood disorders are associated with an increased risk of aging-related diseases, which greatly contribute to the excess morbidity and mortality observed in affected individuals. Clinical and molecular findings also suggest that mood disorders might be characterized by a permanent state of low-grade inflammation. At the cellular level, aging translates into telomeres shortening. Intriguingly, inflammation and telomere shortening show a bidirectional association: a pro-inflammatory state seems to contribute to aging and telomere dysfunction, and telomere attrition is able to induce low-grade inflammation. Several independent studies have reported shorter telomere length and increased levels of circulating inflammatory cytokines in mood disorders, suggesting a complex interplay between altered inflammatory–immune responses and telomere dynamics in the etiopathogenesis of these disorders. In this review, we critically discuss studies investigating the role of telomere attrition and inflammation in the pathogenesis and course of mood disorders, and in pharmacological treatments with psychotropic medications.
Europe PubMed Centra... arrow_drop_down Publikationer från Uppsala Universitet; Digitala Vetenskapliga Arkivet - Academic Archive On-lineOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu42 citations 42 popularity Top 10% influence Average impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Publikationer från Uppsala Universitet; Digitala Vetenskapliga Arkivet - Academic Archive On-lineOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Italy, SwitzerlandAmerican Medical Association (AMA) NIH | Collaborative Genetic Stu..., NIH | A COLLABORATIVE GENOMIC S..., NIH | A Collaborative Genomic S... +9 projectsNIH| Collaborative Genetic Study of Bipolar Disorder ,NIH| A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER ,NIH| A Collaborative Genomic Study of Bipolar Disorder ,NIH| Human Genetics of Addiction: A Study of Common and Specific Factors ,NIH| Collaborative Genomic Study of Bipolar Disorder ,NIH| COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER ,NIH| A Collaborative Genomic Study of Bipolar Disorder ,SNSF| NCCR SYNAPSY: The synaptic bases of mental diseases (phase II) ,NIH| A Collaborative Genomic Study of Bipolar Disorder ,NIH| A Collaborative Genomic Study of Bipolar Disoder ,CIHR ,NIH| Mapping Genes for Mood and Anxiety DisordersAzmeraw T. Amare; Klaus Oliver Schubert; Liping Hou; Scott R. Clark; Sergi Papiol; Urs Heilbronner; Franziska Degenhardt; Fasil Tekola-Ayele; Yi-Hsiang Hsu; Tatyana Shekhtman; Mazda Adli; Nirmala Akula; Kazufumi Akiyama; Raffaella Ardau; Bárbara Arias; Jean-Michel Aubry; Lena Backlund; Abesh Kumar Bhattacharjee; Frank Bellivier; Antonio Benabarre; Susanne Bengesser; Joanna M. Biernacka; Armin Birner; Clara Brichant-Petitjean; Pablo Cervantes; Hsi-Chung Chen; Caterina Chillotti; Sven Cichon; Cristiana Cruceanu; Piotr M. Czerski; Nina Dalkner; Alexandre Dayer; Maria Del Zompo; J. Raymond DePaulo; Bruno Etain; Peter Falkai; Andreas J. Forstner; Louise Frisén; Mark A. Frye; Janice M. Fullerton; Sébastien Gard; Julie Garnham; Fernando S. Goes; Maria Grigoroiu-Serbanescu; Paul Grof; Ryota Hashimoto; Joanna Hauser; Stefan Herms; Per Hoffmann; Andrea Hofmann; Stéphane Jamain; Esther Jiménez; Jean-Pierre Kahn; Layla Kassem; Po-Hsiu Kuo; Tadafumi Kato; John R. Kelsoe; Sarah Kittel-Schneider; Sebastian Kliwicki; Barbara König; Ichiro Kusumi; Gonzalo Laje; Mikael Landén; Catharina Lavebratt; Marion Leboyer; Susan G. Leckband; Alfonso Tortorella; Mirko Manchia; Lina Martinsson; Michael McCarthy; Susan L. McElroy; Francesc Colom; Marina Mitjans; Francis M. Mondimore; Palmiero Monteleone; Caroline M. Nievergelt; Markus M. Nöthen; Tomas Novak; Claire O'Donovan; Norio Ozaki; Urban Ösby; Andrea Pfennig; James B. Potash; Andreas Reif; Eva Z. Reininghaus; Guy A. Rouleau; Janusz K. Rybakowski; Martin Schalling; Peter R. Schofield; Barbara W. Schweizer; Giovanni Severino; Paul D. Shilling; Katzutaka Shimoda; Christian Simhandl; Claire Slaney; Alessio Squassina; Thomas Stamm; Pavla Stopkova; Mario Maj; Gustavo Turecki; Eduard Vieta; Julia Volkert; Stephanie H. Witt; Adam Wright; Peter P. Zandi; Philip B. Mitchell; Michael Bauer; Martin Alda; Marcella Rietschel; Francis J. McMahon; Thomas G. Schulze; Bernhard T. Baune;IMPORTANCE Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ). OBJECTIVES To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association. DESIGN, SETTING, AND PARTICIPANTS A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013.Weighted SCZ polygenic scores were computed at different P value thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36 989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017. MAIN OUTCOMES AND MEASURES Treatment response to lithiumwas defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained. RESULTS Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a threshold P < 5 ? 10-2. Patients with BPAD who had a low polygenic load for SCZ responded better to lithium, with odds ratios for lithium response ranging from 3.46 (95%CI, 1.42-8.41) at the first decile to 2.03 (95%CI, 0.86-4.81) at the ninth decile, compared with the patients in the 10th decile of SCZ risk. In the cross-trait meta-GWAS, 15 genetic loci that may have overlapping effects on lithium treatment response and susceptibility to SCZ were identified. Functional pathway and network analysis of these loci point to the HLA antigen complex and inflammatory cytokines. CONCLUSIONS AND RELEVANCE This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.
JAMA Psychiatry arrow_drop_down Archivio della Ricerca - Università di SalernoArticle . 2018Data sources: Archivio della Ricerca - Università di Salernoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu109 citations 109 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert JAMA Psychiatry arrow_drop_down Archivio della Ricerca - Università di SalernoArticle . 2018Data sources: Archivio della Ricerca - Università di Salernoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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