Loading
description Publicationkeyboard_double_arrow_right Article 2019MDPI AG Elisa Conde Moreno; Alejandro Pascual; Daniel Prieto-Cuadra; Val F. Laza; Javier Molina-Cerrillo; Miren Edurne Ramos-Muñoz; Esperanza Macarena Rodríguez-Serrano; José Luis Soto; Alfredo Carrato; María Laura García-Bermejo; Carmen Guillén-Ponce;microRNAs (miRNA) expression in colorectal (CR) primary tumours can facilitate a more precise molecular characterization. We identified and validated a miRNA profile associated with clinical and histopathological features that might be useful for patient stratification. In situ hybridization array using paraffin-embedded biopsies of CR primary tumours were used to screen 1436 miRNAs. 17 miRNAs were selected for validation by quantitative reverse transcription polymerase chain reaction (qRT-PCR) (n = 192) and were further correlated with clinical and histopathological data. We demonstrated that miRNAs associated to Colorectal Cancer (CRC) diagnosis age (over 50s and 60s) included miR-1-3p, miR-23b-3p, miR-27b-3p, miR-143-3p, miR-145-5p and miR-193b-5p. miR-23b-3p and miR-24-3p discriminated between Lynch Syndrome and sporadic CRC. miR-10a-5p, miR-20a-5p, miR-642b and Let-7a-5p were associated to stroma abundance. miR-642b and Let-7a-5p were associated with to peritumoral inflammation abundance. miR-1-3p, miR-143-3p and miR-145-5p correlated with mucinous component. miR-326 correlated with tumour location (right or left sided). miR-1-3p associated with tumour grade. miR-20a-5p, miR-193b-5p, miR-320a, miR-326 and miR-642b-3p associated to tumour stage and progression. Remarkably, we also demonstrated that miR-1-3p and miR-326 expression significantly associated with patient overall survival (OS). Hierarchical clustering and bioinformatics analysis indicated that selected miRNAs could re-classify the patients and work cooperatively, modulating common target genes involved in colorectal cancer key signalling pathways. In conclusion, molecular characterization of CR primary tumours based on miRNAs could lead to more accurate patient reclassification and may be useful for efficient patient management.
Cancers arrow_drop_down Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/cancers11030346&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Cancers arrow_drop_down Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/cancers11030346&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2017.74.1173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2017.74.1173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 2012Springer Netherlands Authors: Makiko Yashiro; Anantha Kumar Duraiappah; Nicolas Kosoy;Makiko Yashiro; Anantha Kumar Duraiappah; Nicolas Kosoy;Existing institutions are often designed to address issues related to specific ecosystem services, not taking into account interactions and trade-offs among different ecosystem services. This chapter illustrates the effectiveness of a nested institutional approach for managing a bundle of ecosystem services, taking into account complex interactions among multiple uses, user groups and values of services, as well as the existence of multiple property regimes. It starts by providing an overview of the concept and features of common goods and services, followed by the discussions on a concept of the new “commons” introduced by the Japan Satoyama-Satoumi Assessment in 2010, a system of co-management of ecosystem services and biodiversity within private and public land.
https://doi.org/10.1... arrow_drop_down https://doi.org/10.1007/978-94...Part of book or chapter of book . 2012License: Springer Nature TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-94-007-5176-7_10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down https://doi.org/10.1007/978-94...Part of book or chapter of book . 2012License: Springer Nature TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-94-007-5176-7_10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020Embargo end date: 01 Jan 2020 FrancearXiv Roueff, Antoine; Gerin, Maryvonne; Gratier, Pierre; Levrier, François; Pety, Jérôme; Gaudel, Mathilde; Goicoechea, Javier,; Orkisz, Jan; De Souza Magalhaes, Victor; Vono, Maxime; Bardeau, Sébastien; Bron, Emeric; Chanussot, Jocelyn; Chainais, Pierre; Guzman, Viviana; Hughes, Annie; Kainulainen, Jouni; Languignon, David; Le Bourlot, Jacques; Le Petit, Franck; Liszt, Harvey; marchal, antoine; Miville-Deschênes, Marc-Antoine; Peretto, Nicolas; Roueff, Evelyne; Sievers, Albrecht;CO isotopologue transitions are routinely observed in molecular clouds to probe the column density of the gas, the elemental ratios of carbon and oxygen, and to trace the kinematics of the environment. We aim at estimating the abundances, excitation temperatures, velocity field and velocity dispersions of the three main CO isotopologues towards a subset of the Orion B molecular cloud. We use the Cramer Rao Bound (CRB) technique to analyze and estimate the precision of the physical parameters in the framework of local-thermodynamic-equilibrium excitation and radiative transfer with an additive white Gaussian noise. We propose a maximum likelihood estimator to infer the physical conditions from the 1-0 and 2-1 transitions of CO isotopologues. Simulations show that this estimator is unbiased and efficient for a common range of excitation temperatures and column densities (Tex > 6 K, N > 1e14 - 1e15 cm-2). Contrary to the general assumptions, the different CO isotopologues have distinct excitation temperatures, and the line intensity ratios between different isotopologues do not accurately reflect the column density ratios. We find mean fractional abundances that are consistent with previous determinations towards other molecular clouds. However, significant local deviations are inferred, not only in regions exposed to UV radiation field but also in shielded regions. These deviations result from the competition between selective photodissociation, chemical fractionation, and depletion on grain surfaces. We observe that the velocity dispersion of the C18O emission is 10% smaller than that of 13CO. The substantial gain resulting from the simultaneous analysis of two different rotational transitions of the same species is rigorously quantified. The CRB technique is a promising avenue for analyzing the estimation of physical parameters from the fit of spectral lines. 27 pages, 23 PDF figures. Accepted for publication in A&A. Uses aa latex macro
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.2005.08317&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.2005.08317&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsElsevier BV Martín-Burriel, I.; Andrés-Lasheras, S.; Harders, F.; Mainar-Jaime, R.C.; Ranera, B.; Zaragoza, P.; Falceto, V.; Bolea, Y.; Kuijper, E.J.; Bolea, R.; Bossers, A.; Chirino-Trejo, M.;Clostridium difficile is an anaerobic spore-forming bacillus that usually causes gastrointestinal disorders in man and other animal species. Most of the strains isolated from animals are toxigenic being the virulent ribotype (RT) 078 predominant in several animal species. Although C. difficile is pathogenic to both humans and animals, there is no direct evidence of zoonosis. Deep genome sequencing provides sufficient resolution to analyse which strains found in animals might be related to human pathogens. So far, there are only a few fully sequenced genomes of C. difficile strains isolated from domestic and wild animals. Using Illumina technology, we have sequenced the genome of three isolates; a strain isolated from the vagina of a sow (5754), one from rat (Rattus spp) intestinal content (RC10) and a third one isolated from environmental rat faeces (RF17). Both, rat and rat faeces were sampled in fattening pig farms. Our study reveals a close genetic relationship of two of these isolates with the virulent strain M120 (RT078) isolated from a human patient. The analysis of the sequences has revealed the presence of antibiotic resistance genes, mobile elements, including the transposon linked with virulence Tn6164, and the similarity of virulence factors between these isolates and human strains. This is the first study focused on the sequencing of C. difficile genomes obtained from wild animals like rats, which can be considered as potential reservoirs for humans and other animal species. This study can help to understand the genome composition and epidemiology of this bacterium species.
Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.anaerobe.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.anaerobe.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 GermanyBMJ Winau, L.; Baydes, R.H.; Braner, A.; Drott, U.; Burkhardt, H.; Sangle, S.; D'Cruz, D.P.; Carr-White, G.; Marber, M.; Schnoes, K.; Arendt, C.; Klingel, K.; Vogl, T.J.; Zeiher, A.M.; Nagel, E.; Puntmann, V.O.;pmid: 30077990
BackgroundCardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic resonance (CMR).Methods and resultsThis is a two-centre (London and Frankfurt) CMR imaging study at 3.0 Tesla of consecutive 92 patients with SLE free of cardiac symptoms, undergoing screening for cardiac involvement. Venous samples were drawn and analysed post-hoc for cardiac biomarkers, including hs-TropT, high-sensitive C reactive protein and N-terminal pro brain natriuretic peptide. Compared with age-matched/gender-matched non-SLE controls (n=78), patients had significantly raised cardiac biomarker levels, native T1 and T2, aortic and ventricular stiffness, and reduced global longitudinal strain (p<0.01). In SLE, hs-TropT was significantly and independently associated with native T2, followed by the models including native T1 and aortic stiffness (Χ2 0.462, p<0.01). There were no relationships between hs-TropT and age, gender, CV risk factors, duration of systemic disease, cardiac structure or function, or late gadolinium enhancement.ConclusionsPatients with SLE have a high prevalence of subclinical myocardial injury as demonstrated by raised high-sensitive troponin levels. CMR with T2 mapping reveals myocardial oedema as the strongest predictor of hs-TropT release, underscoring the inflammatory interstitial remodelling as the main mechanism of injury. Patients without active myocardial inflammation demonstrate diffuse interstitial remodelling and increased vascular stiffness. These findings substantiate the role of CMR in screening of subclinical cardiac involvement.Trial registration numerNCT02407197; Results.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/annrheumdis-2018-213661&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/annrheumdis-2018-213661&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 Italy, France, Italy, Italy, Italy, Spain, ItalyOxford University Press (OUP) UKRI | AlwaysClean, UKRI | Integrated Mobile Welding...UKRI| AlwaysClean ,UKRI| Integrated Mobile Welding For High Strength In-Field Pipe ManufacturingLiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; Aurlien, R.; Azzoni, S.; Baccigalupi, C.; Banday, A. J.; Banerji, R.; Barreiro, R. B.; Bartolo, N.; Bautista, L.; Beck, D.; Beckman, S.; Bersanelli, M.; Boulanger, F.; Brilenkov, M.; Bucher, M.; Calabrese, E.; Campeti, P.; Carones, A.; Casas, F. J.; Catalano, A.; Chan, V.; Cheung, K.; Chinone, Y.; Clark, S. E.; Columbro, F.; D'Alessandro, G.; de Bernardis, P.; de Haan, T.; de la Hoz, E.; De Petris, M.; Della Torre, S.; Diego-Palazuelos, P.; Dobbs, M.; Dotani, T.; Duval, J. M.; Elleflot, T.; Eriksen, H. K.; Errard, J.; Essinger-Hileman, T.; Finelli, F.; Flauger, R.; Franceschet, C.; Fuskeland, U.; Galloway, M.; Ganga, K.; Gerbino, M.; Gervasi, M.; Génova-Santos, R. T.; Ghigna, T.; Giardiello, S.; Gjerløw, E.; Grain, J.; Grupp, F.; Gruppuso, A.; Gudmundsson, J. E.; Halverson, N. W.; Hargrave, P.; Hasebe, T.; Hasegawa, M.; Hazumi, M.; Henrot-Versillé, S.; Hensley, B.; Hergt, L. T.; Herman, D.; Hivon, E.; Hlozek, R. A.; Hornsby, A. L.; Hoshino, Y.; Hubmayr, J.; Ichiki, K.; Iida, T.; Imada, H.; Ishino, H.; Jaehnig, G.; Katayama, N.; Kato, A.; Keskitalo, R.; Kisner, T.; Kobayashi, Y.; Kogut, A.; Kohri, K.; Komatsu, E.; Komatsu, K.; Konishi, K.; Krachmalnicoff, N.; Kuo, C. L.; Lamagna, L.; Lattanzi, M.; Lee, A. T.; Leloup, C.; Levrier, F.; Linder, E.; Luzzi, G.; Macias-Perez, J.; Maciaszek, T.; Maffei, B.; Maino, D.; Mandelli, S.; Martínez-González, E.; Masi, S.; Massa, M.; Matarrese, S.; Matsuda, F. T.; Matsumura, T.; Mele, L.; Migliaccio, M.; Minami, Y.; Moggi, A.; Montgomery, J.; Montier, L.; Morgante, G.; Mot, B.; Nagano, Y.; Nagasaki, T.; Nagata, R.; Nakano, R.; Namikawa, T.; Nati, F.; Natoli, P.; Nerval, S.; Noviello, F.; Odagiri, K.; Oguri, S.; Ohsaki, H.; Pagano, L.; Paiella, A.; Paoletti, D.; Passerini, A.; Patanchon, G.; Piacentini, F.; Piat, M.; Pisano, G.; Polenta, G.; Poletti, D.; Prouvé, T.; Puglisi, G.; Rambaud, D.; Raum, C.; Realini, S.; Reinecke, M.; Remazeilles, M.; Ritacco, A.; Roudil, G.; Rubino-Martin, J. A.; Russell, M.; Sakurai, H.; Sakurai, Y.; Sasaki, M.; Scott, D.; Sekimoto, Y.; Shinozaki, K.; Shiraishi, M.; Shirron, P.; Signorelli, G.; Spinella, F.; Stever, S.; Stompor, R.; Sugiyama, S.; Sullivan, R. M.; Suzuki, A.; Svalheim, T. L.; Switzer, E.; Takaku, R.; Takakura, H.; Takase, Y.; Tartari, A.; Terao, Y.; Thermeau, J.; Thommesen, H.; Thompson, K. L.; Tomasi, M.; Tominaga, M.; Tristram, M.; Tsuji, M.; Tsujimoto, M.; Vacher, L.; Vielva, P.; Vittorio, N.; Wang, W.; Watanuki, K.; Wehus, I. K.; Weller, J.; Westbrook, B.; Wilms, J.; Winter, B.; Wollack, E. J.; Yumoto, J.; Zannoni, M.;handle: 20.500.11767/132550 , 2434/947309 , 11577/3467499 , 10261/306493 , 11573/1685127
This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ptep/ptac150&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ptep/ptac150&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1103/physrevlett.109.211802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1103/physrevlett.109.211802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021American Society of Clinical Oncology (ASCO) Authors: Leonard Joseph Appleman; Michael Paul Kolinsky; William R. Berry; Margitta Retz; +16 AuthorsLeonard Joseph Appleman; Michael Paul Kolinsky; William R. Berry; Margitta Retz; Loic Mourey; Josep M. Piulats; Emanuela Romano; Gwenaelle Gravis; Howard Gurney; Johann S. de Bono; Martin Boegemann; Urban Emmenegger; Anthony M. Joshua; Christophe Massard; Srikala S. Sridhar; Henry Jacob Conter; Xin Tong Li; Charles Schloss; Christian Heinrich Poehlein; Evan Y. Yu;10 Background: For men with mCRPC, systemic therapies such as docetaxel and cabazitaxel improve survival, but more effective treatments are needed. KEYNOTE-365 (NCT02861573) is a phase 1b/2 study to examine the safety and efficacy of pembro in combination with 4 different study medications (cohorts A, B, C, D) in mCRPC. Previous data from cohort B with a median of 20 months of follow-up showed that pembro + docetaxel and prednisone was well tolerated and had antitumor activity in patients (pts) with mCRPC previously treated with abi or enza. New efficacy and safety data after an additional year of follow-up are presented. Methods: Cohort B enrolled pts who did not respond to or were intolerant to ≥4 weeks of abi or enza in the prechemotherapy mCRPC state and whose disease progressed within 6 months of screening (determined by PSA progression or radiologic bone/soft tissue progression). Pts received pembro 200 mg IV every 3 weeks (Q3W), docetaxel 75 mg/m2 IV Q3W, and oral prednisone 5 mg twice daily. Primary end points were safety, PSA response rate (PSA decrease >50% from baseline), and ORR per RECIST v1.1 by blinded independent central review. Efficacy and safety were assessed in all pts as treated. Results: Of the 104 treated pts, median age was 68.0 years (range, 50-86), 23.1% had PD-L1–positive tumors (combined positive score ≥1), 25.0% had visceral disease, and 50.0% had measurable disease. Median time from enrollment to data cutoff was 32.4 months (range 13.9-40.3); 101 pts discontinued, primarily because of disease progression (77.9%). Efficacy outcomes are reported in the table below. Treatment-related adverse events (TRAEs) occurred in 100 pts (96.2%); the most frequent (≥30%) were diarrhea (41.3%), fatigue (41.3%), and alopecia (40.4%). Grade 3-5 TRAEs occurred in 46 pts (44.2%). Five pts (4.8%) died of AEs; 2 were treatment-related pneumonitis. Conclusions: After another year of follow-up, pembro + docetaxel and prednisone showed improved ORR and PSA response rates compared to the prior dataset in pts with mCRPC previously treated with abi or enza. Safety was consistent with known profiles of each agent and will be further evaluated in a phase 3 study (KEYNOTE-921). Clinical trial information: NCT02861573. [Table: see text]
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2021.39.6_suppl.10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2021.39.6_suppl.10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
description Publicationkeyboard_double_arrow_right Article 2019MDPI AG Elisa Conde Moreno; Alejandro Pascual; Daniel Prieto-Cuadra; Val F. Laza; Javier Molina-Cerrillo; Miren Edurne Ramos-Muñoz; Esperanza Macarena Rodríguez-Serrano; José Luis Soto; Alfredo Carrato; María Laura García-Bermejo; Carmen Guillén-Ponce;microRNAs (miRNA) expression in colorectal (CR) primary tumours can facilitate a more precise molecular characterization. We identified and validated a miRNA profile associated with clinical and histopathological features that might be useful for patient stratification. In situ hybridization array using paraffin-embedded biopsies of CR primary tumours were used to screen 1436 miRNAs. 17 miRNAs were selected for validation by quantitative reverse transcription polymerase chain reaction (qRT-PCR) (n = 192) and were further correlated with clinical and histopathological data. We demonstrated that miRNAs associated to Colorectal Cancer (CRC) diagnosis age (over 50s and 60s) included miR-1-3p, miR-23b-3p, miR-27b-3p, miR-143-3p, miR-145-5p and miR-193b-5p. miR-23b-3p and miR-24-3p discriminated between Lynch Syndrome and sporadic CRC. miR-10a-5p, miR-20a-5p, miR-642b and Let-7a-5p were associated to stroma abundance. miR-642b and Let-7a-5p were associated with to peritumoral inflammation abundance. miR-1-3p, miR-143-3p and miR-145-5p correlated with mucinous component. miR-326 correlated with tumour location (right or left sided). miR-1-3p associated with tumour grade. miR-20a-5p, miR-193b-5p, miR-320a, miR-326 and miR-642b-3p associated to tumour stage and progression. Remarkably, we also demonstrated that miR-1-3p and miR-326 expression significantly associated with patient overall survival (OS). Hierarchical clustering and bioinformatics analysis indicated that selected miRNAs could re-classify the patients and work cooperatively, modulating common target genes involved in colorectal cancer key signalling pathways. In conclusion, molecular characterization of CR primary tumours based on miRNAs could lead to more accurate patient reclassification and may be useful for efficient patient management.
Cancers arrow_drop_down Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/cancers11030346&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Cancers arrow_drop_down Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/cancers11030346&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2017.74.1173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2017.74.1173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 2012Springer Netherlands Authors: Makiko Yashiro; Anantha Kumar Duraiappah; Nicolas Kosoy;Makiko Yashiro; Anantha Kumar Duraiappah; Nicolas Kosoy;Existing institutions are often designed to address issues related to specific ecosystem services, not taking into account interactions and trade-offs among different ecosystem services. This chapter illustrates the effectiveness of a nested institutional approach for managing a bundle of ecosystem services, taking into account complex interactions among multiple uses, user groups and values of services, as well as the existence of multiple property regimes. It starts by providing an overview of the concept and features of common goods and services, followed by the discussions on a concept of the new “commons” introduced by the Japan Satoyama-Satoumi Assessment in 2010, a system of co-management of ecosystem services and biodiversity within private and public land.
https://doi.org/10.1... arrow_drop_down https://doi.org/10.1007/978-94...Part of book or chapter of book . 2012License: Springer Nature TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-94-007-5176-7_10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down https://doi.org/10.1007/978-94...Part of book or chapter of book . 2012License: Springer Nature TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-94-007-5176-7_10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020Embargo end date: 01 Jan 2020 FrancearXiv Roueff, Antoine; Gerin, Maryvonne; Gratier, Pierre; Levrier, François; Pety, Jérôme; Gaudel, Mathilde; Goicoechea, Javier,; Orkisz, Jan; De Souza Magalhaes, Victor; Vono, Maxime; Bardeau, Sébastien; Bron, Emeric; Chanussot, Jocelyn; Chainais, Pierre; Guzman, Viviana; Hughes, Annie; Kainulainen, Jouni; Languignon, David; Le Bourlot, Jacques; Le Petit, Franck; Liszt, Harvey; marchal, antoine; Miville-Deschênes, Marc-Antoine; Peretto, Nicolas; Roueff, Evelyne; Sievers, Albrecht;CO isotopologue transitions are routinely observed in molecular clouds to probe the column density of the gas, the elemental ratios of carbon and oxygen, and to trace the kinematics of the environment. We aim at estimating the abundances, excitation temperatures, velocity field and velocity dispersions of the three main CO isotopologues towards a subset of the Orion B molecular cloud. We use the Cramer Rao Bound (CRB) technique to analyze and estimate the precision of the physical parameters in the framework of local-thermodynamic-equilibrium excitation and radiative transfer with an additive white Gaussian noise. We propose a maximum likelihood estimator to infer the physical conditions from the 1-0 and 2-1 transitions of CO isotopologues. Simulations show that this estimator is unbiased and efficient for a common range of excitation temperatures and column densities (Tex > 6 K, N > 1e14 - 1e15 cm-2). Contrary to the general assumptions, the different CO isotopologues have distinct excitation temperatures, and the line intensity ratios between different isotopologues do not accurately reflect the column density ratios. We find mean fractional abundances that are consistent with previous determinations towards other molecular clouds. However, significant local deviations are inferred, not only in regions exposed to UV radiation field but also in shielded regions. These deviations result from the competition between selective photodissociation, chemical fractionation, and depletion on grain surfaces. We observe that the velocity dispersion of the C18O emission is 10% smaller than that of 13CO. The substantial gain resulting from the simultaneous analysis of two different rotational transitions of the same species is rigorously quantified. The CRB technique is a promising avenue for analyzing the estimation of physical parameters from the fit of spectral lines. 27 pages, 23 PDF figures. Accepted for publication in A&A. Uses aa latex macro
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.2005.08317&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.2005.08317&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsElsevier BV Martín-Burriel, I.; Andrés-Lasheras, S.; Harders, F.; Mainar-Jaime, R.C.; Ranera, B.; Zaragoza, P.; Falceto, V.; Bolea, Y.; Kuijper, E.J.; Bolea, R.; Bossers, A.; Chirino-Trejo, M.;Clostridium difficile is an anaerobic spore-forming bacillus that usually causes gastrointestinal disorders in man and other animal species. Most of the strains isolated from animals are toxigenic being the virulent ribotype (RT) 078 predominant in several animal species. Although C. difficile is pathogenic to both humans and animals, there is no direct evidence of zoonosis. Deep genome sequencing provides sufficient resolution to analyse which strains found in animals might be related to human pathogens. So far, there are only a few fully sequenced genomes of C. difficile strains isolated from domestic and wild animals. Using Illumina technology, we have sequenced the genome of three isolates; a strain isolated from the vagina of a sow (5754), one from rat (Rattus spp) intestinal content (RC10) and a third one isolated from environmental rat faeces (RF17). Both, rat and rat faeces were sampled in fattening pig farms. Our study reveals a close genetic relationship of two of these isolates with the virulent strain M120 (RT078) isolated from a human patient. The analysis of the sequences has revealed the presence of antibiotic resistance genes, mobile elements, including the transposon linked with virulence Tn6164, and the similarity of virulence factors between these isolates and human strains. This is the first study focused on the sequencing of C. difficile genomes obtained from wild animals like rats, which can be considered as potential reservoirs for humans and other animal species. This study can help to understand the genome composition and epidemiology of this bacterium species.
Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.anaerobe.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.anaerobe.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 GermanyBMJ Winau, L.; Baydes, R.H.; Braner, A.; Drott, U.; Burkhardt, H.; Sangle, S.; D'Cruz, D.P.; Carr-White, G.; Marber, M.; Schnoes, K.; Arendt, C.; Klingel, K.; Vogl, T.J.; Zeiher, A.M.; Nagel, E.; Puntmann, V.O.;pmid: 30077990
BackgroundCardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic resonance (CMR).Methods and resultsThis is a two-centre (London and Frankfurt) CMR imaging study at 3.0 Tesla of consecutive 92 patients with SLE free of cardiac symptoms, undergoing screening for cardiac involvement. Venous samples were drawn and analysed post-hoc for cardiac biomarkers, including hs-TropT, high-sensitive C reactive protein and N-terminal pro brain natriuretic peptide. Compared with age-matched/gender-matched non-SLE controls (n=78), patients had significantly raised cardiac biomarker levels, native T1 and T2, aortic and ventricular stiffness, and reduced global longitudinal strain (p<0.01). In SLE, hs-TropT was significantly and independently associated with native T2, followed by the models including native T1 and aortic stiffness (Χ2 0.462, p<0.01). There were no relationships between hs-TropT and age, gender, CV risk factors, duration of systemic disease, cardiac structure or function, or late gadolinium enhancement.ConclusionsPatients with SLE have a high prevalence of subclinical myocardial injury as demonstrated by raised high-sensitive troponin levels. CMR with T2 mapping reveals myocardial oedema as the strongest predictor of hs-TropT release, underscoring the inflammatory interstitial remodelling as the main mechanism of injury. Patients without active myocardial inflammation demonstrate diffuse interstitial remodelling and increased vascular stiffness. These findings substantiate the role of CMR in screening of subclinical cardiac involvement.Trial registration numerNCT02407197; Results.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/annrheumdis-2018-213661&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/annrheumdis-2018-213661&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 Italy, France, Italy, Italy, Italy, Spain, ItalyOxford University Press (OUP) UKRI | AlwaysClean, UKRI | Integrated Mobile Welding...UKRI| AlwaysClean ,UKRI| Integrated Mobile Welding For High Strength In-Field Pipe ManufacturingLiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; Aurlien, R.; Azzoni, S.; Baccigalupi, C.; Banday, A. J.; Banerji, R.; Barreiro, R. B.; Bartolo, N.; Bautista, L.; Beck, D.; Beckman, S.; Bersanelli, M.; Boulanger, F.; Brilenkov, M.; Bucher, M.; Calabrese, E.; Campeti, P.; Carones, A.; Casas, F. J.; Catalano, A.; Chan, V.; Cheung, K.; Chinone, Y.; Clark, S. E.; Columbro, F.; D'Alessandro, G.; de Bernardis, P.; de Haan, T.; de la Hoz, E.; De Petris, M.; Della Torre, S.; Diego-Palazuelos, P.; Dobbs, M.; Dotani, T.; Duval, J. M.; Elleflot, T.; Eriksen, H. K.; Errard, J.; Essinger-Hileman, T.; Finelli, F.; Flauger, R.; Franceschet, C.; Fuskeland, U.; Galloway, M.; Ganga, K.; Gerbino, M.; Gervasi, M.; Génova-Santos, R. T.; Ghigna, T.; Giardiello, S.; Gjerløw, E.; Grain, J.; Grupp, F.; Gruppuso, A.; Gudmundsson, J. E.; Halverson, N. W.; Hargrave, P.; Hasebe, T.; Hasegawa, M.; Hazumi, M.; Henrot-Versillé, S.; Hensley, B.; Hergt, L. T.; Herman, D.; Hivon, E.; Hlozek, R. A.; Hornsby, A. L.; Hoshino, Y.; Hubmayr, J.; Ichiki, K.; Iida, T.; Imada, H.; Ishino, H.; Jaehnig, G.; Katayama, N.; Kato, A.; Keskitalo, R.; Kisner, T.; Kobayashi, Y.; Kogut, A.; Kohri, K.; Komatsu, E.; Komatsu, K.; Konishi, K.; Krachmalnicoff, N.; Kuo, C. L.; Lamagna, L.; Lattanzi, M.; Lee, A. T.; Leloup, C.; Levrier, F.; Linder, E.; Luzzi, G.; Macias-Perez, J.; Maciaszek, T.; Maffei, B.; Maino, D.; Mandelli, S.; Martínez-González, E.; Masi, S.; Massa, M.; Matarrese, S.; Matsuda, F. T.; Matsumura, T.; Mele, L.; Migliaccio, M.; Minami, Y.; Moggi, A.; Montgomery, J.; Montier, L.; Morgante, G.; Mot, B.; Nagano, Y.; Nagasaki, T.; Nagata, R.; Nakano, R.; Namikawa, T.; Nati, F.; Natoli, P.; Nerval, S.; Noviello, F.; Odagiri, K.; Oguri, S.; Ohsaki, H.; Pagano, L.; Paiella, A.; Paoletti, D.; Passerini, A.; Patanchon, G.; Piacentini, F.; Piat, M.; Pisano, G.; Polenta, G.; Poletti, D.; Prouvé, T.; Puglisi, G.; Rambaud, D.; Raum, C.; Realini, S.; Reinecke, M.; Remazeilles, M.; Ritacco, A.; Roudil, G.; Rubino-Martin, J. A.; Russell, M.; Sakurai, H.; Sakurai, Y.; Sasaki, M.; Scott, D.; Sekimoto, Y.; Shinozaki, K.; Shiraishi, M.; Shirron, P.; Signorelli, G.; Spinella, F.; Stever, S.; Stompor, R.; Sugiyama, S.; Sullivan, R. M.; Suzuki, A.; Svalheim, T. L.; Switzer, E.; Takaku, R.; Takakura, H.; Takase, Y.; Tartari, A.; Terao, Y.; Thermeau, J.; Thommesen, H.; Thompson, K. L.; Tomasi, M.; Tominaga, M.; Tristram, M.; Tsuji, M.; Tsujimoto, M.; Vacher, L.; Vielva, P.; Vittorio, N.; Wang, W.; Watanuki, K.; Wehus, I. K.; Weller, J.; Westbrook, B.; Wilms, J.; Winter, B.; Wollack, E. J.; Yumoto, J.; Zannoni, M.;handle: 20.500.11767/132550 , 2434/947309 , 11577/3467499 , 10261/306493 , 11573/1685127
This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ptep/ptac150&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ptep/ptac150&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1103/physrevlett.109.211802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1103/physrevlett.109.211802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021American Society of Clinical Oncology (ASCO) Authors: Leonard Joseph Appleman; Michael Paul Kolinsky; William R. Berry; Margitta Retz; +16 AuthorsLeonard Joseph Appleman; Michael Paul Kolinsky; William R. Berry; Margitta Retz; Loic Mourey; Josep M. Piulats; Emanuela Romano; Gwenaelle Gravis; Howard Gurney; Johann S. de Bono; Martin Boegemann; Urban Emmenegger; Anthony M. Joshua; Christophe Massard; Srikala S. Sridhar; Henry Jacob Conter; Xin Tong Li; Charles Schloss; Christian Heinrich Poehlein; Evan Y. Yu;10 Background: For men with mCRPC, systemic therapies such as docetaxel and cabazitaxel improve survival, but more effective treatments are needed. KEYNOTE-365 (NCT02861573) is a phase 1b/2 study to examine the safety and efficacy of pembro in combination with 4 different study medications (cohorts A, B, C, D) in mCRPC. Previous data from cohort B with a median of 20 months of follow-up showed that pembro + docetaxel and prednisone was well tolerated and had antitumor activity in patients (pts) with mCRPC previously treated with abi or enza. New efficacy and safety data after an additional year of follow-up are presented. Methods: Cohort B enrolled pts who did not respond to or were intolerant to ≥4 weeks of abi or enza in the prechemotherapy mCRPC state and whose disease progressed within 6 months of screening (determined by PSA progression or radiologic bone/soft tissue progression). Pts received pembro 200 mg IV every 3 weeks (Q3W), docetaxel 75 mg/m2 IV Q3W, and oral prednisone 5 mg twice daily. Primary end points were safety, PSA response rate (PSA decrease >50% from baseline), and ORR per RECIST v1.1 by blinded independent central review. Efficacy and safety were assessed in all pts as treated. Results: Of the 104 treated pts, median age was 68.0 years (range, 50-86), 23.1% had PD-L1–positive tumors (combined positive score ≥1), 25.0% had visceral disease, and 50.0% had measurable disease. Median time from enrollment to data cutoff was 32.4 months (range 13.9-40.3); 101 pts discontinued, primarily because of disease progression (77.9%). Efficacy outcomes are reported in the table below. Treatment-related adverse events (TRAEs) occurred in 100 pts (96.2%); the most frequent (≥30%) were diarrhea (41.3%), fatigue (41.3%), and alopecia (40.4%). Grade 3-5 TRAEs occurred in 46 pts (44.2%). Five pts (4.8%) died of AEs; 2 were treatment-related pneumonitis. Conclusions: After another year of follow-up, pembro + docetaxel and prednisone showed improved ORR and PSA response rates compared to the prior dataset in pts with mCRPC previously treated with abi or enza. Safety was consistent with known profiles of each agent and will be further evaluated in a phase 3 study (KEYNOTE-921). Clinical trial information: NCT02861573. [Table: see text]
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2021.39.6_suppl.10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2021.39.6_suppl.10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu