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- Stereochemistry-dependent thermotropic liquid crystalline phases of monosaccharide-based amphiphiles
description Publicationkeyboard_double_arrow_right Article 2023 FinlandRoyal Society of Chemistry (RSC) EC | BioELCellEC| BioELCellIda Mattsson; Johanna Majoinen; Manu Lahtinen; Thomas Sandberg; Anna Fogde; Tiina Saloranta-Simell; Orlando J. Rojas; Olli Ikkala; Reko Leino;| openaire: EC/H2020/788489/EU//BioELCell Funding Information: The Graduate School of Chemical Engineering, the Parliament Office Commission of the Åland Islands, Walter and Lisi Waal's foundation, the Finnish Foundation for Technology Promotion and the Society of Swedish Literature in Finland are gratefully acknowledged for funding this work. Dr J. Rahkila, Turku Centre for Chemical and Molecular Analytics is acknowledged for HRMS analysis of the allylated sugars and NMR-related support. Dr Ville Liljeström is thanked for assistance with the SWAXS measurements. Dr J. Majoinen and Prof. O. Rojas acknowledge funding from the H2020-ERC-2017-Advanced Grant ‘BioELCell’ (788489). Prof. O. Rojas acknowledges the Canada Excellence Research Chair Program (CERC-2018-00006) and Canada Foundation for Innovation (Project number 38623). Prof. Olli Ikkala acknowledges Academy of Finland CoE LIBER (Project number 346108) and the Flagship FinnCERES. The authors acknowledge facilities and technical support by Nanomicroscopy Center at Aalto University. Publisher Copyright: © 2023 The Royal Society of Chemistry. Conformational rigidity controls the bulk self-assembly and liquid crystallinity from amphiphilic block molecules to copolymers. The effects of block stereochemistry on the self-assembly have, however, been less explored. Here, we have investigated amphiphilic block molecules involving eight open-chain monosaccharide-based polyol units possessing different stereochemistries, derived from d-glucose, d-galactose, l-arabinose, d-mannose and l-rhamnose (allylated monosaccharides t-Glc*, e-Glc*, t-Gal*, e-Gal*, t-Ara*, e-Ara*, t-Man*, and t-Rha*), end-functionalized with repulsive tetradecyl alkyl chain blocks to form well-defined amphiphiles with block molecule structures. All compounds studied showed low temperature crystalline phases due to polyol crystallization, and smectic (lamellar) and isotropic phases upon heating in bulk. Hexagonal cylindrical phase was additionally observed for the composition involving t-Man*. Cubic phases were observed for e-Glc*, e-Gal*, e-Ara*, and t-Rha* derived compounds. Therein,the rich array of WAXS-reflections suggested that the crystalline polyol domains are not ultra-confined in spheres as in classic cubic phases but instead show network-like phase continuity, which is rare in bulk liquid crystals. Importantly, the transition temperatures of the self-assemblies were observed to depend strongly on the polyol stereochemistry. The findings underpin that the stereochemistry in carbohydrate-based assemblies involves complexity, which is an important parameter to be considered in material design when developing self-assemblies for different functions. Peer reviewed
Jyväskylä University... arrow_drop_down Jyväskylä University Digital ArchiveArticle . 2023License: CC BYData sources: Jyväskylä University Digital ArchiveSoft Matter; VTT Research Information SystemArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Jyväskylä University... arrow_drop_down Jyväskylä University Digital ArchiveArticle . 2023License: CC BYData sources: Jyväskylä University Digital ArchiveSoft Matter; VTT Research Information SystemArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu description Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013Springer Science and Business Media LLC EC | ENGAGE, WTEC| ENGAGE ,WTAuthors: Cecelja, Marina; Frost, Michelle L.; Spector, Tim D.; Chowienczyk, Phil;Cecelja, Marina; Frost, Michelle L.; Spector, Tim D.; Chowienczyk, Phil;pmid: 23407824
Abdominal aortic calcification (AAC) is an independent determinant of cardiovascular events. Computed tomography (CT) is currently the gold standard measure of AAC but is limited by high radiation exposure. Lateral dual-energy X-ray absorptiometry (DXA) has the potential to detect AAC at a fraction of the radiation dose. Our objective was to determine the accuracy of lateral-DXA in detecting AAC compared to CT in healthy women. Women from the TwinsUK registry aged 52-80 years (n = 105) underwent noncontrast CT and lateral-DXA imaging of the abdominal aorta at lumbar vertebrae L1-L4. Presence of calcium on CT was scored using the volume method. Lateral-DXA images were scored using the previously validated semiquantitative 24-point score and simplified 8-point score. Calcification was present in 81 % of women as determined by CT and 49 % with lateral-DXA. The mean volume score and the 24- and 8-point scores of AAC were 0.20 ± 0.41 cm(2), 2.39 ± 3.91 arbitrary units, and 1.47 ± 2.13 arbitrary units, respectively. There was moderate agreement between CT and 24-point lateral-DXA (Spearman's rank correlation coefficient r = 0.58, P 0.0001). The sensitivity of lateral-DXA for detecting AAC was 56 % and specificity was 80 %. Sensitivity and specificity of lateral-DXA improved to 64 and 84 % when analysis was limited to calcium volumes ≥0.008 cm(3) as detected by CT. Lateral-DXA imaging may provide a useful alternative to CT in detecting AAC with minimal radiation exposure, which may be used with concurrent bone mineral density assessment.
Calcified Tissue Int... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Calcified Tissue Int... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Conference object , Article 2020 Czech RepublicIEEE NSERC, EC | UTHOTPNSERC ,EC| UTHOTPde Rezende, Susanna F.; Meir, Or; Nordstr��m, Jakob; Pitassi, Toniann; Robere, Robert; Vinyals, Marc;handle: 11104/0317277
We significantly strengthen and generalize the theorem lifting Nullstellensatz degree to monotone span program size by Pitassi and Robere (2018) so that it works for any gadget with high enough rank, in particular, for useful gadgets such as equality and greater-than. We apply our generalized theorem to solve three open problems: •We present the first result that demonstrates a separation in proof power for cutting planes with unbounded versus polynomially bounded coefficients. Specifically, we exhibit CNF formulas that can be refuted in quadratic length and constant line space in cutting planes with unbounded coefficients, but for which there are no refutations in subexponential length and subpolynomial line space if coefficients are restricted to be of polynomial magnitude. •We give the first explicit separation between monotone Boolean formulas and monotone real formulas. Specifically, we give an explicit family of functions that can be computed with monotone real formulas of nearly linear size but require monotone Boolean formulas of exponential size. Previously only a non-explicit separation was known. •We give the strongest separation to-date between monotone Boolean formulas and monotone Boolean circuits. Namely, we show that the classical GEN problem, which has polynomial-size monotone Boolean circuits, requires monotone Boolean formulas of size $2^{\Omega(n/\text{polylog}(n))}$ . An important technical ingredient, which may be of independent interest, is that we show that the Nullstellensatz degree of refuting the pebbling formula over a DAG $G$ over any field coincides exactly with the reversible pebbling price of $G$ . In particular, this implies that the standard decision tree complexity and the parity decision tree complexity of the corresponding falsified clause search problem are equal. This is an extended abstract. The full version of the paper is available at https://arxiv.org/abs/2001.02144.
arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2015Embargo end date: 01 Jan 2015arXiv EC | CHARMING, NSERCEC| CHARMING ,NSERCAuthors: Zhu, E. Y.; Corbari, C.; Kazansky, P. G.; Qian, L.;Zhu, E. Y.; Corbari, C.; Kazansky, P. G.; Qian, L.;We experimentally demonstrate a simple method to measure the biphoton joint spectrum by mapping the spectral information onto the temporal domain using a dispersive medium. Various top-hat spectral filters are used to limit the spectral (and hence, temporal) extent of the broadband downconversion photons measured. The sharp edges of the spectral filters are utilized as spectral markers for dispersion characterization of the dispersive medium. This method allows dispersion characterization and joint spectral measurement to be completed simultaneously. The joint spectrum (which extends beyond 100 nm, centered about 1.5 micron) of the type-II downconverted photon pairs generated from a poled optical fiber is obtained with this method. Comment: 6 pages, 4 figures
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2015License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2015License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomAmerican Association for Cancer Research (AACR) EC | SITlessEC| SITlessAuthors: Pamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; +10 AuthorsPamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; Chee Wee Ong; Jenny Worthington; Ian G. Mills; Daniel B. Longley; James P. Quigley; Amina Zoubeidi; Johann S. de Bono; Elena Deryugina; Melissa J. LaBonte; David J.J. Waugh;Abstract Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clinical response. Understanding resistance mechanisms, including the role of AR expressed in other cell types within the tumor microenvironment, will extend the clinical benefit of AR-targeted therapy. Here, we show the ASI enzalutamide induces vascular catastrophe and promotes hypoxia and microenvironment adaptation. We characterize treatment-induced hypoxia, and subsequent induction of angiogenesis, as novel mechanisms of relapse to enzalutamide, highlighting the importance of two hypoxia-regulated cytokines in underpinning relapse. We confirmed AR expression in CD34+ vascular endothelium of biopsy tissue and human vascular endothelial cells (HVEC). Enzalutamide attenuated angiogenic tubule formation and induced cytotoxicity in HVECs in vitro, and rapidly induced sustained hypoxia in LNCaP xenografts. Subsequent reoxygenation, following prolonged enzalutamide treatment, was associated with increased tumor vessel density and accelerated tumor growth. Hypoxia increased AR expression and transcriptional activity in prostate cells in vitro. Coinhibition of IL8 and VEGF-A restored tumor response in the presence of enzalutamide, confirming the functional importance of their elevated expression in enzalutamide-resistant models. Moreover, coinhibition of IL8 and VEGF-A resulted in a durable, effective resolution of enzalutamide-sensitive prostate tumors. We conclude that concurrent inhibition of two hypoxia-induced factors, IL8 and VEGF-A, prolongs tumor sensitivity to enzalutamide in preclinical models and may delay the onset of enzalutamide resistance. Implications: Targeting hypoxia-induced signaling may extend the therapeutic benefit of enzalutamide, providing an improved treatment strategy for patients with resistant disease.
Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 4visibility views 4 download downloads 5 Powered bymore_vert Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 SpainWiley NSERC, EC | SUPERCELLNSERC ,EC| SUPERCELLJuan Pablo Esquivel; Perla Alday; Omar A. Ibrahim; B. Fernández; Erik Kjeang; Neus Sabaté;handle: 20.500.12327/1737 , 10261/212272
This article presents a new approach for environmentally benign, low-cost batteries intended for single-use applications. The proposed battery is designed and fabricated using exclusively organic materials such as cellulose, carbon, and wax and features an integrated quinone-based redox chemistry to generate electricity within a compact form factor. This primary capillary flow battery is activated by the addition of a liquid sample and has shown continuous operation up to 100 min with an output voltage that can be conveniently scaled to match the voltage needs of portable electronic devices (1.5–3.0 V). Once depleted, the battery can be disposed of without the need for any recycling facility, as its components are nontoxic and shown to be biotically degradable in a standardized test. The practical utility of the battery is demonstrated by direct substitution of a lithium ion coin cell in a diagnostic application. info:eu-repo/semantics/publishedVersion
Advanced Energy Mate... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu61 citations 61 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 16visibility views 16 download downloads 72 Powered bymore_vert Advanced Energy Mate... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2022 Germany SSHRC, EC | InterAccentSSHRC ,EC| InterAccentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______314::38454667640b868ff309eb095d1e09f1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______314::38454667640b868ff309eb095d1e09f1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2009 NetherlandsAmerican Association for the Advancement of Science (AAAS) EC | PULSARS WITH LOFAR, NSERCEC| PULSARS WITH LOFAR ,NSERCAnne M. Archibald; Ingrid H. Stairs; Scott M. Ransom; Victoria M. Kaspi; V. I. Kondratiev; Duncan R. Lorimer; Maura McLaughlin; Jason Boyles; Jason W. T. Hessels; Ryan S. Lynch; Joeri van Leeuwen; Mallory S. E. Roberts; Frederick Jenet; David Champion; R. Rosen; Brad N. Barlow; B. H. Dunlap; Ronald A. Remillard;handle: 11245/1.313487
pmid: 19520945
Radio pulsars with millisecond spin periods are thought to have been spun up by transfer of matter and angular momentum from a low-mass companion star during an X-ray-emitting phase. The spin periods of the neutron stars in several such low-mass X-ray binary (LMXB) systems have been shown to be in the millisecond regime, but no radio pulsations have been detected. Here we report on detection and follow-up observations of a nearby radio millisecond pulsar (MSP) in a circular binary orbit with an optically identified companion star. Optical observations indicate that an accretion disk was present in this system within the last decade. Our optical data show no evidence that one exists today, suggesting that the radio MSP has turned on after a recent LMXB phase. Comment: published in Science
Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu434 citations 434 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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- Stereochemistry-dependent thermotropic liquid crystalline phases of monosaccharide-based amphiphiles
description Publicationkeyboard_double_arrow_right Article 2023 FinlandRoyal Society of Chemistry (RSC) EC | BioELCellEC| BioELCellIda Mattsson; Johanna Majoinen; Manu Lahtinen; Thomas Sandberg; Anna Fogde; Tiina Saloranta-Simell; Orlando J. Rojas; Olli Ikkala; Reko Leino;| openaire: EC/H2020/788489/EU//BioELCell Funding Information: The Graduate School of Chemical Engineering, the Parliament Office Commission of the Åland Islands, Walter and Lisi Waal's foundation, the Finnish Foundation for Technology Promotion and the Society of Swedish Literature in Finland are gratefully acknowledged for funding this work. Dr J. Rahkila, Turku Centre for Chemical and Molecular Analytics is acknowledged for HRMS analysis of the allylated sugars and NMR-related support. Dr Ville Liljeström is thanked for assistance with the SWAXS measurements. Dr J. Majoinen and Prof. O. Rojas acknowledge funding from the H2020-ERC-2017-Advanced Grant ‘BioELCell’ (788489). Prof. O. Rojas acknowledges the Canada Excellence Research Chair Program (CERC-2018-00006) and Canada Foundation for Innovation (Project number 38623). Prof. Olli Ikkala acknowledges Academy of Finland CoE LIBER (Project number 346108) and the Flagship FinnCERES. The authors acknowledge facilities and technical support by Nanomicroscopy Center at Aalto University. Publisher Copyright: © 2023 The Royal Society of Chemistry. Conformational rigidity controls the bulk self-assembly and liquid crystallinity from amphiphilic block molecules to copolymers. The effects of block stereochemistry on the self-assembly have, however, been less explored. Here, we have investigated amphiphilic block molecules involving eight open-chain monosaccharide-based polyol units possessing different stereochemistries, derived from d-glucose, d-galactose, l-arabinose, d-mannose and l-rhamnose (allylated monosaccharides t-Glc*, e-Glc*, t-Gal*, e-Gal*, t-Ara*, e-Ara*, t-Man*, and t-Rha*), end-functionalized with repulsive tetradecyl alkyl chain blocks to form well-defined amphiphiles with block molecule structures. All compounds studied showed low temperature crystalline phases due to polyol crystallization, and smectic (lamellar) and isotropic phases upon heating in bulk. Hexagonal cylindrical phase was additionally observed for the composition involving t-Man*. Cubic phases were observed for e-Glc*, e-Gal*, e-Ara*, and t-Rha* derived compounds. Therein,the rich array of WAXS-reflections suggested that the crystalline polyol domains are not ultra-confined in spheres as in classic cubic phases but instead show network-like phase continuity, which is rare in bulk liquid crystals. Importantly, the transition temperatures of the self-assemblies were observed to depend strongly on the polyol stereochemistry. The findings underpin that the stereochemistry in carbohydrate-based assemblies involves complexity, which is an important parameter to be considered in material design when developing self-assemblies for different functions. Peer reviewed
Jyväskylä University... arrow_drop_down Jyväskylä University Digital ArchiveArticle . 2023License: CC BYData sources: Jyväskylä University Digital ArchiveSoft Matter; VTT Research Information SystemArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Jyväskylä University... arrow_drop_down Jyväskylä University Digital ArchiveArticle . 2023License: CC BYData sources: Jyväskylä University Digital ArchiveSoft Matter; VTT Research Information SystemArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu description Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013Springer Science and Business Media LLC EC | ENGAGE, WTEC| ENGAGE ,WTAuthors: Cecelja, Marina; Frost, Michelle L.; Spector, Tim D.; Chowienczyk, Phil;Cecelja, Marina; Frost, Michelle L.; Spector, Tim D.; Chowienczyk, Phil;pmid: 23407824
Abdominal aortic calcification (AAC) is an independent determinant of cardiovascular events. Computed tomography (CT) is currently the gold standard measure of AAC but is limited by high radiation exposure. Lateral dual-energy X-ray absorptiometry (DXA) has the potential to detect AAC at a fraction of the radiation dose. Our objective was to determine the accuracy of lateral-DXA in detecting AAC compared to CT in healthy women. Women from the TwinsUK registry aged 52-80 years (n = 105) underwent noncontrast CT and lateral-DXA imaging of the abdominal aorta at lumbar vertebrae L1-L4. Presence of calcium on CT was scored using the volume method. Lateral-DXA images were scored using the previously validated semiquantitative 24-point score and simplified 8-point score. Calcification was present in 81 % of women as determined by CT and 49 % with lateral-DXA. The mean volume score and the 24- and 8-point scores of AAC were 0.20 ± 0.41 cm(2), 2.39 ± 3.91 arbitrary units, and 1.47 ± 2.13 arbitrary units, respectively. There was moderate agreement between CT and 24-point lateral-DXA (Spearman's rank correlation coefficient r = 0.58, P 0.0001). The sensitivity of lateral-DXA for detecting AAC was 56 % and specificity was 80 %. Sensitivity and specificity of lateral-DXA improved to 64 and 84 % when analysis was limited to calcium volumes ≥0.008 cm(3) as detected by CT. Lateral-DXA imaging may provide a useful alternative to CT in detecting AAC with minimal radiation exposure, which may be used with concurrent bone mineral density assessment.
Calcified Tissue Int... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Calcified Tissue Int... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Conference object , Article 2020 Czech RepublicIEEE NSERC, EC | UTHOTPNSERC ,EC| UTHOTPde Rezende, Susanna F.; Meir, Or; Nordstr��m, Jakob; Pitassi, Toniann; Robere, Robert; Vinyals, Marc;handle: 11104/0317277
We significantly strengthen and generalize the theorem lifting Nullstellensatz degree to monotone span program size by Pitassi and Robere (2018) so that it works for any gadget with high enough rank, in particular, for useful gadgets such as equality and greater-than. We apply our generalized theorem to solve three open problems: •We present the first result that demonstrates a separation in proof power for cutting planes with unbounded versus polynomially bounded coefficients. Specifically, we exhibit CNF formulas that can be refuted in quadratic length and constant line space in cutting planes with unbounded coefficients, but for which there are no refutations in subexponential length and subpolynomial line space if coefficients are restricted to be of polynomial magnitude. •We give the first explicit separation between monotone Boolean formulas and monotone real formulas. Specifically, we give an explicit family of functions that can be computed with monotone real formulas of nearly linear size but require monotone Boolean formulas of exponential size. Previously only a non-explicit separation was known. •We give the strongest separation to-date between monotone Boolean formulas and monotone Boolean circuits. Namely, we show that the classical GEN problem, which has polynomial-size monotone Boolean circuits, requires monotone Boolean formulas of size $2^{\Omega(n/\text{polylog}(n))}$ . An important technical ingredient, which may be of independent interest, is that we show that the Nullstellensatz degree of refuting the pebbling formula over a DAG $G$ over any field coincides exactly with the reversible pebbling price of $G$ . In particular, this implies that the standard decision tree complexity and the parity decision tree complexity of the corresponding falsified clause search problem are equal. This is an extended abstract. The full version of the paper is available at https://arxiv.org/abs/2001.02144.
arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2015Embargo end date: 01 Jan 2015arXiv EC | CHARMING, NSERCEC| CHARMING ,NSERCAuthors: Zhu, E. Y.; Corbari, C.; Kazansky, P. G.; Qian, L.;Zhu, E. Y.; Corbari, C.; Kazansky, P. G.; Qian, L.;We experimentally demonstrate a simple method to measure the biphoton joint spectrum by mapping the spectral information onto the temporal domain using a dispersive medium. Various top-hat spectral filters are used to limit the spectral (and hence, temporal) extent of the broadband downconversion photons measured. The sharp edges of the spectral filters are utilized as spectral markers for dispersion characterization of the dispersive medium. This method allows dispersion characterization and joint spectral measurement to be completed simultaneously. The joint spectrum (which extends beyond 100 nm, centered about 1.5 micron) of the type-II downconverted photon pairs generated from a poled optical fiber is obtained with this method. Comment: 6 pages, 4 figures
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2015License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2015License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomAmerican Association for Cancer Research (AACR) EC | SITlessEC| SITlessAuthors: Pamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; +10 AuthorsPamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; Chee Wee Ong; Jenny Worthington; Ian G. Mills; Daniel B. Longley; James P. Quigley; Amina Zoubeidi; Johann S. de Bono; Elena Deryugina; Melissa J. LaBonte; David J.J. Waugh;Abstract Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clinical response. Understanding resistance mechanisms, including the role of AR expressed in other cell types within the tumor microenvironment, will extend the clinical benefit of AR-targeted therapy. Here, we show the ASI enzalutamide induces vascular catastrophe and promotes hypoxia and microenvironment adaptation. We characterize treatment-induced hypoxia, and subsequent induction of angiogenesis, as novel mechanisms of relapse to enzalutamide, highlighting the importance of two hypoxia-regulated cytokines in underpinning relapse. We confirmed AR expression in CD34+ vascular endothelium of biopsy tissue and human vascular endothelial cells (HVEC). Enzalutamide attenuated angiogenic tubule formation and induced cytotoxicity in HVECs in vitro, and rapidly induced sustained hypoxia in LNCaP xenografts. Subsequent reoxygenation, following prolonged enzalutamide treatment, was associated with increased tumor vessel density and accelerated tumor growth. Hypoxia increased AR expression and transcriptional activity in prostate cells in vitro. Coinhibition of IL8 and VEGF-A restored tumor response in the presence of enzalutamide, confirming the functional importance of their elevated expression in enzalutamide-resistant models. Moreover, coinhibition of IL8 and VEGF-A resulted in a durable, effective resolution of enzalutamide-sensitive prostate tumors. We conclude that concurrent inhibition of two hypoxia-induced factors, IL8 and VEGF-A, prolongs tumor sensitivity to enzalutamide in preclinical models and may delay the onset of enzalutamide resistance. Implications: Targeting hypoxia-induced signaling may extend the therapeutic benefit of enzalutamide, providing an improved treatment strategy for patients with resistant disease.
Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 4visibility views 4 download downloads 5 Powered bymore_vert Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 SpainWiley NSERC, EC | SUPERCELLNSERC ,EC| SUPERCELLJuan Pablo Esquivel; Perla Alday; Omar A. Ibrahim; B. Fernández; Erik Kjeang; Neus Sabaté;handle: 20.500.12327/1737 , 10261/212272
This article presents a new approach for environmentally benign, low-cost batteries intended for single-use applications. The proposed battery is designed and fabricated using exclusively organic materials such as cellulose, carbon, and wax and features an integrated quinone-based redox chemistry to generate electricity within a compact form factor. This primary capillary flow battery is activated by the addition of a liquid sample and has shown continuous operation up to 100 min with an output voltage that can be conveniently scaled to match the voltage needs of portable electronic devices (1.5–3.0 V). Once depleted, the battery can be disposed of without the need for any recycling facility, as its components are nontoxic and shown to be biotically degradable in a standardized test. The practical utility of the battery is demonstrated by direct substitution of a lithium ion coin cell in a diagnostic application. info:eu-repo/semantics/publishedVersion
Advanced Energy Mate... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/aenm.201700275&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu61 citations 61 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 16visibility views 16 download downloads 72 Powered bymore_vert Advanced Energy Mate... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/aenm.201700275&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2022 Germany SSHRC, EC | InterAccentSSHRC ,EC| InterAccentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______314::38454667640b868ff309eb095d1e09f1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______314::38454667640b868ff309eb095d1e09f1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2009 NetherlandsAmerican Association for the Advancement of Science (AAAS) EC | PULSARS WITH LOFAR, NSERCEC| PULSARS WITH LOFAR ,NSERCAnne M. Archibald; Ingrid H. Stairs; Scott M. Ransom; Victoria M. Kaspi; V. I. Kondratiev; Duncan R. Lorimer; Maura McLaughlin; Jason Boyles; Jason W. T. Hessels; Ryan S. Lynch; Joeri van Leeuwen; Mallory S. E. Roberts; Frederick Jenet; David Champion; R. Rosen; Brad N. Barlow; B. H. Dunlap; Ronald A. Remillard;handle: 11245/1.313487
pmid: 19520945
Radio pulsars with millisecond spin periods are thought to have been spun up by transfer of matter and angular momentum from a low-mass companion star during an X-ray-emitting phase. The spin periods of the neutron stars in several such low-mass X-ray binary (LMXB) systems have been shown to be in the millisecond regime, but no radio pulsations have been detected. Here we report on detection and follow-up observations of a nearby radio millisecond pulsar (MSP) in a circular binary orbit with an optically identified companion star. Optical observations indicate that an accretion disk was present in this system within the last decade. Our optical data show no evidence that one exists today, suggesting that the radio MSP has turned on after a recent LMXB phase. Comment: published in Science
Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/science.1172740&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu434 citations 434 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/science.1172740&type=result"></script>'); --> </script>
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