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description Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 NetherlandsSpringer Science and Business Media LLC E, Stragier; R, Massart; M, Salery; M, Hamon; D, Geny; V, Martin; F, Boulle; L, Lanfumey;doi: 10.1038/mp.2014.38
pmid: 24776738
High ethanol intake is well known to induce both anxiolytic and anxiogenic effects, in correlation with chromatin remodeling in the amygdaloid brain region and deficits in cell proliferation and survival in the hippocampus of rodents. Whether only moderate but chronic ethanol intake in C57BL/6J mice could also have an impact on chromatin remodeling and neuroplasticity was addressed here. Chronic ethanol consumption in a free choice paradigm was found to induce marked changes in the expression of genes implicated in neural development and histone post-translational modifications in the mouse hippocampus. Transcripts encoding neural bHLH activators and those from Bdnf exons II, III and VI were upregulated, whereas those from Bdnf exon VIII and Hdacs were downregulated by ethanol compared with water consumption. These ethanol-induced changes were associated with enrichment in both acetylated H3 at Bdnf promoter PVI and trimethylated H3 at PII and PIII. Conversely, acetylated H3 at PIII and PVIII and trimethylated H3 at PVIII were decreased in ethanol-exposed mice. In parallel, hippocampal brain-derived neurotrophic factor (BDNF) levels and TrkB-mediated neurogenesis in the dentate gyrus were significantly enhanced by ethanol consumption. These results suggest that, in C57BL/6J mice, chronic and moderate ethanol intake produces marked epigenetic changes underlying BDNF overexpression and downstream hippocampal neurogenesis.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu51 citations 51 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2018 United KingdomCenter for Open Science AKA | Intra-Genomic Conflicts a...AKA| Intra-Genomic Conflicts and Social Decision-Making in HumansLinda C. Karlsson; Jan Antfolk; Hanna Putkonen; Sabine Amon; João da Silva Guerreiro; Vivienne de Vogel; Sandra Flynn; Ghitta Weizmann-Henelius;pmid: 30704336
Familicides have received relatively little attention in previous research and mostly appear as a byproduct in studies with broader objectives. Here, we reviewed 67 studies from 18 countries, published between 1980 and 2017, that report on familicides in which an offender killed or attempted to kill their current or former spouse/intimate partner and one or more of their biological or stepchildren. Studies were identified by a systematical literature search in PubMed, PsycINFO, and Google Scholar. Only eight studies had the specific aim of investigating familicide, while the remaining studies investigated broader phenomena (e.g., homicide-suicide) but reported on a subsample of familicide cases. We retrieved data concerning the offenders’ gender, age, and background, as well as information regarding victims and their relationship to the offender. We also retrieved contextual factors and characteristics of the offence, such as modus operandi, offence location, possible premeditation, and whether or not the offender had died by suicide in connection to the offence. Furthermore, we coded methodological aspects of the studies, such as data collection coverage and sources of information. Familicides were almost exclusively committed by men and about half of the familicide cases led to the subsequent suicide of the offender. Mental health problems, relationship problems, and financial difficulties were prevalent. Because few studies reported population base rates of the investigated characteristics, it is difficult to draw conclusions about risk factors for familicide. Future research should further investigate typologies of familicide and examine risk factors associated with different types of familicides.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu35 citations 35 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsElsevier BV Martín-Burriel, I.; Andrés-Lasheras, S.; Harders, F.; Mainar-Jaime, R.C.; Ranera, B.; Zaragoza, P.; Falceto, V.; Bolea, Y.; Kuijper, E.J.; Bolea, R.; Bossers, A.; Chirino-Trejo, M.;Clostridium difficile is an anaerobic spore-forming bacillus that usually causes gastrointestinal disorders in man and other animal species. Most of the strains isolated from animals are toxigenic being the virulent ribotype (RT) 078 predominant in several animal species. Although C. difficile is pathogenic to both humans and animals, there is no direct evidence of zoonosis. Deep genome sequencing provides sufficient resolution to analyse which strains found in animals might be related to human pathogens. So far, there are only a few fully sequenced genomes of C. difficile strains isolated from domestic and wild animals. Using Illumina technology, we have sequenced the genome of three isolates; a strain isolated from the vagina of a sow (5754), one from rat (Rattus spp) intestinal content (RC10) and a third one isolated from environmental rat faeces (RF17). Both, rat and rat faeces were sampled in fattening pig farms. Our study reveals a close genetic relationship of two of these isolates with the virulent strain M120 (RT078) isolated from a human patient. The analysis of the sequences has revealed the presence of antibiotic resistance genes, mobile elements, including the transposon linked with virulence Tn6164, and the similarity of virulence factors between these isolates and human strains. This is the first study focused on the sequencing of C. difficile genomes obtained from wild animals like rats, which can be considered as potential reservoirs for humans and other animal species. This study can help to understand the genome composition and epidemiology of this bacterium species.
Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2005 NetherlandsSpringer Science and Business Media LLC Norman Mannella; Wanli Yang; Xingjiang Zhou; Hong Zheng; John F. Mitchell; Jan Zaanen; Thomas P. Devereaux; Naoto Nagaosa; Zahid Hussain; Zhi-Xun Shen;A characteristic feature of the copper oxide high-temperature superconductors is the dichotomy between the electronic excitations along the nodal (diagonal) and antinodal (parallel to the Cu-O bonds) directions in momentum space, generally assumed to be linked to the "d-wave" symmetry of the superconducting state. Angle-resolved photoemission measurements in the superconducting state have revealed a quasiparticle spectrum with a d-wave gap structure that exhibits a maximum along the antinodal direction and vanishes along the nodal direction. Subsequent measurements have shown that, at low doping levels, this gap structure persists even in the high-temperature metallic state, although the nodal points of the superconducting state spread out in finite "Fermi arcs". This is the so-called pseudogap phase, and it has been assumed that it is closely linked to the superconducting state, either by assigning it to fluctuating superconductivity or by invoking orders which are natural competitors of d-wave superconductors. Here we report experimental evidence that a very similar pseudogap state with a nodal-antinodal dichotomous character exists in a system that is markedly different from a superconductor: the ferromagnetic metallic groundstate of the colossal magnetoresistive bilayer manganite La1.2Sr1.8Mn2O7. Our findings therefore cast doubt on the assumption that the pseudogap state in the copper oxides and the nodal-antinodal dichotomy are hallmarks of the superconductivity state. Comment: To appear in Nature
NARCIS arrow_drop_down Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2005https://doi.org/10.48550/arxiv...Article . 2005License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu221 citations 221 popularity Top 10% influence Top 1% impulse Top 1% Powered by BIP!more_vert NARCIS arrow_drop_down Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2005https://doi.org/10.48550/arxiv...Article . 2005License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature04273&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Belgium, ItalyElsevier BV David, Tweats; David A, Eastmond; Anthony M, Lynch; Azeddine, Elhajouji; Roland, Froetschl; Micheline, Kirsch-Volders; Francesco, Marchetti; Kenichi, Masumura; Francesca, Pacchierotti; Maik, Schuler;Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis. However, the relationship between induced aneuploidy occurring after exposure and clonal aneuploidy present in tumours is not clear. Recent evidence indicates that the induction of chromosomal instability (CIN), may be more important than aneuploidy per se, in the carcinogenic process. Down Syndrome, trisomy 21, is associated with altered hematopoiesis in utero which, in combination with subsequent mutations, results in an increased risk for acute megakaryoblastic and lymphoblastic leukemias. In contrast, there is reduced cancer risk for most solid tumours in Down Syndrome. Mouse models with high levels of aneuploidy are also associated with increased cancer risk for particular tumours with long latencies, but paradoxically other types of tumour often show decreased incidence. The aneugens reviewed that induce cancer in humans and animals all possess other carcinogenic properties, such as mutagenicity, clastogenicity, cytotoxicity, organ toxicities, hormonal and epigenetic changes which likely account for, or interact with aneuploidy, to cause carcinogenesis. Although the role that aneuploidy plays in carcinogenesis has not been fully established, in many cases, it may not play a primary causative role. Tubulin-disrupting aneugens that do not possess other properties linked to carcinogenesis, were not carcinogenic in rodents. Similarly, in humans, for the tubulin-disrupting aneugens colchicine and albendazole, there is no reported association with increased cancer risk. There is a need for further mechanistic studies on agents that induce aneuploidy, particularly by mechanisms other than tubulin disruption and to determine the role of aneuploidy in pre-neoplastic events and in early and late stage neoplasia.
ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 NetherlandsAmerican Chemical Society (ACS) Monticelli, Luca; Kandasamy, Senthil K.; Periole, Xavier; Larson, Ronald G.; Tieleman, D. Peter; Marrink, Siewert-Jan;Many biologically interesting phenomena occur on a time scale that is too long to be studied by atomistic simulations. These phenomena include the dynamics of large proteins and self-assembly of biological materials. Coarse-grained (CG) molecular modeling allows computer simulations to be run on length and time scales that are 2-3 orders of magnitude larger compared to atomistic simulations, providing a bridge between the atomistic and the mesoscopic scale. We developed a new CG model for proteins as an extension of the MARTINI force field. Here, we validate the model for its use in peptide-bilayer systems. In order to validate the model, we calculated the potential of mean force for each amino acid as a function of its distance from the center of a dioleoylphosphatidylcholine (DOPC) lipid bilayer. We then compared amino acid association constants, the partitioning of a series of model pentapeptides, the partitioning and orientation,of WALP23 in DOPC lipid bilayers and a series of KALP peptides in dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine (DPPC) bilayers. A comparison with results obtained from atomistic models shows good agreement in all of the tests performed. We also performed a systematic investigation of the partitioning of five series of polyalanine-leucine peptides (with different lengths and compositions) in DPPC bilayers. As expected, the fraction of peptides partitioned at the interface increased with decreasing peptide length and decreasing leucine content, demonstrating that the CG model is capable of discriminating partitioning behavior arising from subtle differences in the amino acid composition. Finally, we simulated the concentration-dependent formation of transmembrane pores by magainin, an antimicrobial peptide. In line with atomistic simulation studies, disordered toroidal pores are formed. In conclusion, the model is computationally efficient and effectively reproduces peptide-lipid interactions and the partitioning of amino acids and peptides in lipid bilayers.
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For further information contact us at helpdesk@openaire.eu2K citations 2,164 popularity Top 0.01% influence Top 0.1% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 NetherlandsSpringer Science and Business Media LLC E, Stragier; R, Massart; M, Salery; M, Hamon; D, Geny; V, Martin; F, Boulle; L, Lanfumey;doi: 10.1038/mp.2014.38
pmid: 24776738
High ethanol intake is well known to induce both anxiolytic and anxiogenic effects, in correlation with chromatin remodeling in the amygdaloid brain region and deficits in cell proliferation and survival in the hippocampus of rodents. Whether only moderate but chronic ethanol intake in C57BL/6J mice could also have an impact on chromatin remodeling and neuroplasticity was addressed here. Chronic ethanol consumption in a free choice paradigm was found to induce marked changes in the expression of genes implicated in neural development and histone post-translational modifications in the mouse hippocampus. Transcripts encoding neural bHLH activators and those from Bdnf exons II, III and VI were upregulated, whereas those from Bdnf exon VIII and Hdacs were downregulated by ethanol compared with water consumption. These ethanol-induced changes were associated with enrichment in both acetylated H3 at Bdnf promoter PVI and trimethylated H3 at PII and PIII. Conversely, acetylated H3 at PIII and PVIII and trimethylated H3 at PVIII were decreased in ethanol-exposed mice. In parallel, hippocampal brain-derived neurotrophic factor (BDNF) levels and TrkB-mediated neurogenesis in the dentate gyrus were significantly enhanced by ethanol consumption. These results suggest that, in C57BL/6J mice, chronic and moderate ethanol intake produces marked epigenetic changes underlying BDNF overexpression and downstream hippocampal neurogenesis.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/mp.2014.38&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu51 citations 51 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/mp.2014.38&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2018 United KingdomCenter for Open Science AKA | Intra-Genomic Conflicts a...AKA| Intra-Genomic Conflicts and Social Decision-Making in HumansLinda C. Karlsson; Jan Antfolk; Hanna Putkonen; Sabine Amon; João da Silva Guerreiro; Vivienne de Vogel; Sandra Flynn; Ghitta Weizmann-Henelius;pmid: 30704336
Familicides have received relatively little attention in previous research and mostly appear as a byproduct in studies with broader objectives. Here, we reviewed 67 studies from 18 countries, published between 1980 and 2017, that report on familicides in which an offender killed or attempted to kill their current or former spouse/intimate partner and one or more of their biological or stepchildren. Studies were identified by a systematical literature search in PubMed, PsycINFO, and Google Scholar. Only eight studies had the specific aim of investigating familicide, while the remaining studies investigated broader phenomena (e.g., homicide-suicide) but reported on a subsample of familicide cases. We retrieved data concerning the offenders’ gender, age, and background, as well as information regarding victims and their relationship to the offender. We also retrieved contextual factors and characteristics of the offence, such as modus operandi, offence location, possible premeditation, and whether or not the offender had died by suicide in connection to the offence. Furthermore, we coded methodological aspects of the studies, such as data collection coverage and sources of information. Familicides were almost exclusively committed by men and about half of the familicide cases led to the subsequent suicide of the offender. Mental health problems, relationship problems, and financial difficulties were prevalent. Because few studies reported population base rates of the investigated characteristics, it is difficult to draw conclusions about risk factors for familicide. Future research should further investigate typologies of familicide and examine risk factors associated with different types of familicides.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/bxjf9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu35 citations 35 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/bxjf9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsElsevier BV Martín-Burriel, I.; Andrés-Lasheras, S.; Harders, F.; Mainar-Jaime, R.C.; Ranera, B.; Zaragoza, P.; Falceto, V.; Bolea, Y.; Kuijper, E.J.; Bolea, R.; Bossers, A.; Chirino-Trejo, M.;Clostridium difficile is an anaerobic spore-forming bacillus that usually causes gastrointestinal disorders in man and other animal species. Most of the strains isolated from animals are toxigenic being the virulent ribotype (RT) 078 predominant in several animal species. Although C. difficile is pathogenic to both humans and animals, there is no direct evidence of zoonosis. Deep genome sequencing provides sufficient resolution to analyse which strains found in animals might be related to human pathogens. So far, there are only a few fully sequenced genomes of C. difficile strains isolated from domestic and wild animals. Using Illumina technology, we have sequenced the genome of three isolates; a strain isolated from the vagina of a sow (5754), one from rat (Rattus spp) intestinal content (RC10) and a third one isolated from environmental rat faeces (RF17). Both, rat and rat faeces were sampled in fattening pig farms. Our study reveals a close genetic relationship of two of these isolates with the virulent strain M120 (RT078) isolated from a human patient. The analysis of the sequences has revealed the presence of antibiotic resistance genes, mobile elements, including the transposon linked with virulence Tn6164, and the similarity of virulence factors between these isolates and human strains. This is the first study focused on the sequencing of C. difficile genomes obtained from wild animals like rats, which can be considered as potential reservoirs for humans and other animal species. This study can help to understand the genome composition and epidemiology of this bacterium species.
Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.anaerobe.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert Research@WUR; Anaero... arrow_drop_down LUMC Scholarly Publications; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.anaerobe.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ehf2.13517&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ehf2.13517&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2005 NetherlandsSpringer Science and Business Media LLC Norman Mannella; Wanli Yang; Xingjiang Zhou; Hong Zheng; John F. Mitchell; Jan Zaanen; Thomas P. Devereaux; Naoto Nagaosa; Zahid Hussain; Zhi-Xun Shen;A characteristic feature of the copper oxide high-temperature superconductors is the dichotomy between the electronic excitations along the nodal (diagonal) and antinodal (parallel to the Cu-O bonds) directions in momentum space, generally assumed to be linked to the "d-wave" symmetry of the superconducting state. Angle-resolved photoemission measurements in the superconducting state have revealed a quasiparticle spectrum with a d-wave gap structure that exhibits a maximum along the antinodal direction and vanishes along the nodal direction. Subsequent measurements have shown that, at low doping levels, this gap structure persists even in the high-temperature metallic state, although the nodal points of the superconducting state spread out in finite "Fermi arcs". This is the so-called pseudogap phase, and it has been assumed that it is closely linked to the superconducting state, either by assigning it to fluctuating superconductivity or by invoking orders which are natural competitors of d-wave superconductors. Here we report experimental evidence that a very similar pseudogap state with a nodal-antinodal dichotomous character exists in a system that is markedly different from a superconductor: the ferromagnetic metallic groundstate of the colossal magnetoresistive bilayer manganite La1.2Sr1.8Mn2O7. Our findings therefore cast doubt on the assumption that the pseudogap state in the copper oxides and the nodal-antinodal dichotomy are hallmarks of the superconductivity state. Comment: To appear in Nature
NARCIS arrow_drop_down Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2005https://doi.org/10.48550/arxiv...Article . 2005License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature04273&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu221 citations 221 popularity Top 10% influence Top 1% impulse Top 1% Powered by BIP!more_vert NARCIS arrow_drop_down Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2005https://doi.org/10.48550/arxiv...Article . 2005License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature04273&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. 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Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Belgium, ItalyElsevier BV David, Tweats; David A, Eastmond; Anthony M, Lynch; Azeddine, Elhajouji; Roland, Froetschl; Micheline, Kirsch-Volders; Francesco, Marchetti; Kenichi, Masumura; Francesca, Pacchierotti; Maik, Schuler;Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis. However, the relationship between induced aneuploidy occurring after exposure and clonal aneuploidy present in tumours is not clear. Recent evidence indicates that the induction of chromosomal instability (CIN), may be more important than aneuploidy per se, in the carcinogenic process. Down Syndrome, trisomy 21, is associated with altered hematopoiesis in utero which, in combination with subsequent mutations, results in an increased risk for acute megakaryoblastic and lymphoblastic leukemias. In contrast, there is reduced cancer risk for most solid tumours in Down Syndrome. Mouse models with high levels of aneuploidy are also associated with increased cancer risk for particular tumours with long latencies, but paradoxically other types of tumour often show decreased incidence. The aneugens reviewed that induce cancer in humans and animals all possess other carcinogenic properties, such as mutagenicity, clastogenicity, cytotoxicity, organ toxicities, hormonal and epigenetic changes which likely account for, or interact with aneuploidy, to cause carcinogenesis. Although the role that aneuploidy plays in carcinogenesis has not been fully established, in many cases, it may not play a primary causative role. Tubulin-disrupting aneugens that do not possess other properties linked to carcinogenesis, were not carcinogenic in rodents. Similarly, in humans, for the tubulin-disrupting aneugens colchicine and albendazole, there is no reported association with increased cancer risk. There is a need for further mechanistic studies on agents that induce aneuploidy, particularly by mechanisms other than tubulin disruption and to determine the role of aneuploidy in pre-neoplastic events and in early and late stage neoplasia.
ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.mrgentox.2019.03.005&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 NetherlandsAmerican Chemical Society (ACS) Monticelli, Luca; Kandasamy, Senthil K.; Periole, Xavier; Larson, Ronald G.; Tieleman, D. Peter; Marrink, Siewert-Jan;Many biologically interesting phenomena occur on a time scale that is too long to be studied by atomistic simulations. These phenomena include the dynamics of large proteins and self-assembly of biological materials. Coarse-grained (CG) molecular modeling allows computer simulations to be run on length and time scales that are 2-3 orders of magnitude larger compared to atomistic simulations, providing a bridge between the atomistic and the mesoscopic scale. We developed a new CG model for proteins as an extension of the MARTINI force field. Here, we validate the model for its use in peptide-bilayer systems. In order to validate the model, we calculated the potential of mean force for each amino acid as a function of its distance from the center of a dioleoylphosphatidylcholine (DOPC) lipid bilayer. We then compared amino acid association constants, the partitioning of a series of model pentapeptides, the partitioning and orientation,of WALP23 in DOPC lipid bilayers and a series of KALP peptides in dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine (DPPC) bilayers. A comparison with results obtained from atomistic models shows good agreement in all of the tests performed. We also performed a systematic investigation of the partitioning of five series of polyalanine-leucine peptides (with different lengths and compositions) in DPPC bilayers. As expected, the fraction of peptides partitioned at the interface increased with decreasing peptide length and decreasing leucine content, demonstrating that the CG model is capable of discriminating partitioning behavior arising from subtle differences in the amino acid composition. Finally, we simulated the concentration-dependent formation of transmembrane pores by magainin, an antimicrobial peptide. In line with atomistic simulation studies, disordered toroidal pores are formed. In conclusion, the model is computationally efficient and effectively reproduces peptide-lipid interactions and the partitioning of amino acids and peptides in lipid bilayers.
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For further information contact us at helpdesk@openaire.eu2K citations 2,164 popularity Top 0.01% influence Top 0.1% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/ct700324x&type=result"></script>'); --> </script>
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