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description Publicationkeyboard_double_arrow_right Article 2016Informa UK Limited G, Remington; J, Lee; O, Agid; H, Takeuchi; G, Foussias; M, Hahn; G, Fervaha; L, Burton; V, Powell;pmid: 27207070
Clozapine was first introduced as an antipsychotic in the 1970's but a cluster of deaths, later linked to the drug's risk of agranulocytosis, led to its withdrawal in most countries. However, work in the 1980's established its unique efficacy in treatment resistant schizophrenia (TRS), which constitutes as many as 30% of those with the illness. Clozapine was reintroduced with this indication shortly thereafter, but because of this risk its use requires routine hematologic monitoring.An update is provided regarding clozapine's risk of neutropenia, agranulocytosis, and associated mortality. In addition, updates are provided on other side effects, specifically myocarditis and bowel obstruction, as evidence suggests these are more common than agranulocytosis and associated with higher mortality rates.Clozapine remains the only treatment indicated in TRS, but it is dramatically underutilized. Clearly there are serious side effects associated with its use, and while the focus has historically been on hematologic concerns, we highlight other side effects that also demand systematic monitoring. Because it is the only effective treatment option we have for TRS, though, efforts must be implemented that ensure its use in this population while maximizing safety.
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For further information contact us at helpdesk@openaire.eu63 citations 63 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023Cold Spring Harbor Laboratory WTWTMarisa C. Hamilton; James D. Fife; Ersin Akinci; Tian Yu; Benyapa Khowpinitchai; Minsun Cha; Sammy Barkal; Thi Tun Thi; Grace H.T. Yeo; Juan Pablo Ramos Barroso; Matthew Jake Francoeur; Minja Velimirovic; David K. Gifford; Guillaume Lettre; Haojie Yu; Christopher A. Cassa; Richard I. Sherwood;pmc: PMC9881906 , PMC10203276
SummaryGenetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening, we have substantially improved the identification of genes whose disruption alters serum LDL-C levels. We identify 21 genes in which rare coding variants significantly alter LDL-C levels at least partially through altered LDL-C uptake. We use co-essentiality-based gene module analysis to show that dysfunction of the RAB10 vesicle transport pathway leads to hypercholesterolemia in humans and mice by impairing surface LDL receptor levels. Further, we demonstrate that loss of function ofOTX2leads to robust reduction in serum LDL-C levels in mice and humans by increasing cellular LDL-C uptake. Altogether, we present an integrated approach that improves our understanding of genetic regulators of LDL-C levels and provides a roadmap for further efforts to dissect complex human disease genetics.
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For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Conference object , Preprint 2019 FranceSpringer International Publishing Quentin Roy; Camelia Zakaria; Simon T. Perrault; Mathieu Nancel; Wonjung Kim; Archan Misra; Andy Cockburn;Part 8: Pointing, Touch, Gesture and Speech-Based Interaction Techniques; International audience; Eyewear displays allow users to interact with virtual content displayed over real-world vision, in active situations like standing and walking. Pointing techniques for eyewear displays have been proposed, but their social acceptability, efficiency, and situation awareness remain to be assessed. Using a novel street-walking simulator, we conducted an empirical study of target acquisition while standing and walking under different levels of street crowdedness. We evaluated three phone-based eyewear pointing techniques: indirect touch on a touchscreen, and two in-air techniques using relative device rotations around forward and a downward axes. Direct touch on a phone, without eyewear, was used as a control condition. Results showed that indirect touch was the most efficient and socially acceptable technique, and that in-air pointing was inefficient when walking. Interestingly, the eyewear displays did not improve situation awareness compared to the control condition. We discuss implications for eyewear interaction design.
https://hal.archives... arrow_drop_down https://hal.archives-ouvertes....Preprint . Part of book or chapter of bookLicense: CC BYData sources: UnpayWallhttps://doi.org/10.1007/978-3-...Part of book or chapter of book . 2019License: Springer Nature TDMData sources: CrossrefHAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYINRIA a CCSD electronic archive server; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert https://hal.archives... arrow_drop_down https://hal.archives-ouvertes....Preprint . Part of book or chapter of bookLicense: CC BYData sources: UnpayWallhttps://doi.org/10.1007/978-3-...Part of book or chapter of book . 2019License: Springer Nature TDMData sources: CrossrefHAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYINRIA a CCSD electronic archive server; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1999Elsevier BV Authors: Lin, Zheng Yan; Choi, Yong-Kab;Lin, Zheng Yan; Choi, Yong-Kab;AbstractIn this paper we establish large increment results and moduli of continuty for a two-parameter fractional Lévy Brownian motion on rectangles in the Euclidean plane via estimating upper bounds of large deviation probabilities on suprema of the two-parameter fractional Lévy Brownian motion.
https://doi.org/10.1... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu16 citations 16 popularity Average influence Top 10% impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Report , Other literature type , Preprint 2018 Turkey, Italy, Italy, Germany, Portugal, Portugal, Italy, United Kingdom, Italy, Italy, Spain, Denmark, Italy, Poland, Italy, Italy, France, ItalySpringer Science and Business Media LLC Aaboud M.; Aad G.; Abbott B.; Abdinov O.; Abeloos B.; Abhayasinghe D. K.; Abidi S. H.; Abouzeid O. S.; Abraham N. L.; Abramowicz H.; Abreu H.; Abulaiti Y.; Acharya B. S.; Adachi S.; Adam L.; Adamczyk L.; Adelman J.; Adersberger M.; Adiguzel A.; Adye T.; Affolder A. A.; Afik Y.; Agheorghiesei C.; Aguilar-Saavedra J. A.; Ahmadov F.; Aielli G.; Akatsuka S.; Åkesson T. P. A.; Akilli E.; Akimov A. V.; Alberghi G. L.; Albert J.; Albicocco P.; Alconada Verzini M. J.; Alderweireldt S.; Aleksa M.; Aleksandrov I. N.; Alexa C.; Alexopoulos T.; Alhroob M.; Ali B.; Alimonti G.; Alison J.; Alkire S. P.; Allaire C.; Allbrooke B. M. M.; Allen B. W.; Allport P. P.; Aloisio A.; Alonso A.; Alonso F.; Alpigiani C.; Alshehri A. A.; Alstaty M. I.; Alvarez Gonzalez B.; Álvarez Piqueras D.; Alviggi M. G.; Amadio B. T.; Amaral Coutinho Y.; Ambler A.; Ambroz L.; Amelung C.; Amidei D.; Amor Dos Santos S. P.; Amoroso S.; Amrouche C. S.; Anastopoulos C.; Ancu L. S.; Andari N.; Andeen T.; Anders C. F.; Anders J. K.; Anderson K. J.; Andreazza A.; Andrei V.; Anelli C. R.; Angelidakis S.; Angelozzi I.; Angerami A.; Anisenkov A. V.; Annovi A.; Antel C.; Anthony M. T.; Antonelli M.; Antrim D. J. A.; Anulli F.; Aoki M.; Aparisi Pozo J. A.; Aperio Bella L.; Arabidze G.; Araque J. P.; Araujo Ferraz V.; Araujo Pereira R.; Arce A. T. H.; Ardell R. E.; Arduh F. A.; Arguin J. -F.; Argyropoulos S.; Armbruster A. J.; Armitage L. J.; Armstrong A.; Arnaez O.; Arnold H.; Arratia M.; Arslan O.; Artamonov A.; Artoni G.; Artz S.; Asai S.; Asbah N.; Asimakopoulou E. M.; Asquith L.; Assamagan K.; Astalos R.; Atkin R. J.; Atkinson M.; Atlay N. 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L.; Soualah R.; Sowden B. C.; Spagnolo S.; Spieker T. M.; Stabile A.; Stanecka E.; Stanislaus B.; Stark G. H.; Starovoitov P.; Stärz S.; Staszewski R.; Stevenson T. J.; Stolte P.; Straessner A.; Strandberg J.; Strizenec P.; Stucci S. A.; Stugu B.; Stupak J.; Sullivan M. J.; Sumida T.; Svatos M.; Swiatlowski M.; Sykora I.; Ta D.; Tahirovic E.; Takai H.; Tapia Araya S.; Tartarelli G. F.; Tassi E.; Taylor A. C.; Taylor A. J.; Terashi K.; Terron J.; Terzo S.; Thiele F.; Thompson A. S.; Thomson E.; Tian Y.; Ticse Torres R. E.; Tikhomirov V. O; Tisserant S.; Tokushuku K.; Tomiwa K. G.; Torró Pastor E.; Toth J.; Trigger I. M.; Trincaz-Duvoid S.; Trocmé B.; Trofymov A.; Troncon C.; Trovato F.; Truong L.; Trzebinski M.; Tsai F.; Tsuno S.; Tu Y.; Tudorache A.; Tudorache V.; Turra R.; Tzovara E.; Ughetto M.; Unal G.; Ungaro F. C.; Urquijo P.; Vadla K. O. H.; Vaidya A.; Valente M.; Valero A.; Valéry L.; Van Daalen T. R.; Van Gemmeren P.; Van Vulpen I.; Vanadia M.; Vari R.; Varvell K. E.; Vazquez Furelos D.; Veloso F.; Veneziano S.; Ventura A.; Vercesi V.; Verducci M.; Vermeulen A. T.; Vetterli M. C.; Viaux Maira N.; Vickey T.; Vickey Boeriu O. E.; Villa M.; Vincter M. G.; Vivarelli I.; Vlachos S.; von Buddenbrock S. E.; Vorobel V.; Vos M.; Vranjes N.; Vranjes Milosavljevic M.; Vukotic I.; Walder J.; Walkowiak W.; Wang A. M.; Wang C.; Wanotayaroj C.; Warburton A.; Wardrope D. R.; Watkins P. M.; Watts G.; Weber C.; Weber M. S.; Weber S. A.; Weingarten J.; Weirich M.; Weiser C.; Wenaus T.; Wengler T.; Werner M. D.; Werner P.; Whalen K.; Wickens F. J.; Wielers M.; Wiglesworth C.; Willocq S.; Winkels E.; Winklmeier F.; Winter B. T.; Wolf A.; Wolter M. W.; Wolters H.; Worm S. D.; Woźniak K. W.; Wu M.; Wu S. L.; Wu X.; Xella S.; Xi Z.; Xu D.; Xu H.; Yabsley B.; Yacoob S.; Yamaguchi D.; Yamazaki T.; Yang H. J.; Yang H. T.; Yap Y. C.; Yigitbasi E.; Yorita K.; Yu J.; Zaidan R.; Zakareishvili T.; Zakharchuk N.; Zanzi D.; Zhang D. F.; Zhang D.; Zhang F.; Zhao P.; Zhemchugov A.; Zhou B.; Zhu C. G.; Zoch K.; Zorbas T. G.;We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5
CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 30visibility views 30 download downloads 50 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013Wiley Danielle M. Frechette; Alison L. Collins; James T. Harvey; Sean A. Hayes; David D. Huff; Andrew W. Jones; Nicolas A. Retford; Alina E. Langford; Jonathan W. Moore; Ann-Marie K. Osterback; William H. Satterthwaite; Scott A. Shaffer;AbstractAvian predation on juvenile salmonids is an important source of mortality in freshwater and estuarine habitats when birds and salmonids overlap spatially and temporally. We assessed the potential impact of avian predation upon juvenile steelhead Oncorhynchus mykiss in a coastal watershed in central California. We conducted stream surveys between 2008 and 2010 to determine the composition, distribution, and density of piscivorous birds in areas that provide rearing habitat for juvenile steelhead. The most commonly sighted bird species were common mergansers Mergus merganser and belted kingfishers Megacyrle alcyon. The density of avian predators varied spatially and temporally but was greatest in the estuary regardless of season and decreased with increasing distance from the estuary. In the absence of local predator diet data, we applied a bioenergetics model to estimate the potential predation on juvenile steelhead by mergansers and kingfishers in the Scott Creek estuary. Model parameters included (1) published values of bird energetic requirements and steelhead energy density, (2) the number of birds present in the estuary during the closure period (from stream surveys), and (3) the size frequency and abundance of steelhead present in the estuary during closure. We predicted the extent of predation for different values of steelhead in bird diets, accounting for uncertainty in the estimates using a Monte Carlo simulation approach. With the assumed contribution of steelhead to the diet ranging from 20% to 100%, the population of kingfishers foraging in the Scott Creek estuary had the potential to remove 3–17% of annual production, whereas mergansers had the potential to remove 5–54% of annual steelhead production. Our results suggest that predation by avian species, particularly mergansers, is an important source of mortality for threatened steelhead populations in central California and should be addressed in future salmonid research and recovery planning.Received February 13, 2013; accepted June 4, 2013
North American Journ... arrow_drop_down North American Journal of Fisheries ManagementArticle . 2013License: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Average influence Average impulse Average Powered by BIP!more_vert North American Journ... arrow_drop_down North American Journal of Fisheries ManagementArticle . 2013License: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021American Society of Clinical Oncology (ASCO) Jorge E. Cortes; Jane F. Apperley; Elza Lomaia; Beatriz Moiraghi; Maria Undurraga Sutton; Carolina Pavlovsky; Charles Chuah; Tomasz Sacha; Jeffrey H. Lipton; Charles A. Schiffer; James K. McCloskey; Andreas Hochhaus; Philippe Rousselot; Gianantonio Rosti; Hugues de Lavallade; Michael J. Mauro; Tracey Hall; Vickie Lu; Shouryadeep Srivastava; Michael W. Deininger;7000 Background: PON, a third-generation tyrosine kinase inhibitor (TKI), demonstrated deep and long-lasting responses and survival in patients (pts) with chronic-phase chronic myeloid leukemia (CP-CML) resistant/intolerant to second-generation TKI therapy (PACE; NCT01207440); post hoc analysis suggested a relationship between dose and both adverse events and response. Here we present the primary analysis of OPTIC (NCT02467270), an ongoing, randomized, phase 2 trial with a novel response-based dosing regimen of PON in pts with resistant/intolerant CP-CML. Methods: Pts with CP-CML resistant/intolerant to ≥2 TKIs or with the BCR-ABL1 T315I mutation were randomized to PON starting doses of 45 mg (cohort A; 45 mg → 15 mg), 30 mg (B; 30 mg →15 mg), and 15 mg (C) once daily. Doses were reduced to 15 mg with achievement of ≤1% BCR-ABL1IS in cohorts A and B. The primary endpoint is ≤1% BCR-ABL1IS at 12 mo; secondary endpoints include cytogenetic and molecular responses and safety outcomes. AOEs were adjudicated prospectively by an independent review committee. Results: 283 pts were randomized (A/B/C: n=94/95/94) and had the following baseline characteristics: median age 48 y (18‒81 y); 98% received ≥2 (55% ≥3) TKIs; 99% had resistant disease; 40% had ≥1 baseline mutations (23% T315I). At the primary analysis with 32 mo median follow-up, 134 pts (47%; n=50/41/43) remained on treatment and 204 pts (72%) had PON exposure ≥12 mo. At 12 mo, 44% (41/93) in A, 29% (27/93) in B, and 23% (21/91) in C achieved ≤1% BCR-ABL1IS (Table); primary endpoint was met by cohort A. Dose reductions to 15 mg after achieving response (A/B) were 48/29%. Most common grades ≥3 TEAEs were thrombocytopenia, 27%; neutropenia, 17%; and anemia, 7%. AOEs/serious AOEs were reported in cohorts A (10%/4%), B (5%/4%), and C (3%/3%). Dose reductions or discontinuations for TEAEs (A/B/C) were 46/35/32% and 19/16/14%, respectively. Conclusions: The OPTIC primary analysis demonstrates the optimal benefit:risk profile for PON was achieved with a response-based dosing regimen starting with 45 mg/d, followed by dose reduction to 15 mg/d upon achieving ≤ 1% BCR-ABL1IS; 30 mg→15 mg and 15 mg cohorts may provide benefit, especially in pts without T315I mutation (Table). The observed ≤1% BCR-ABL1IS responses are supported by robust survival outcomes in pts with CP-CML resistant to second-generation BCR-ABL1 TKI therapy, both with and without BCR-ABL1 mutations. Clinical trial information: NCT02467270. [Table: see text]
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For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015Public Library of Science (PLoS) Sumaiyah Mat; Pey June Tan; Chin Teck Ng; Farhana Fadzli; Faizatul I Rozalli; Ee Ming Khoo; Keith D Hill; Maw Pin Tan;Osteoarthritis (OA) exacerbates skeletal muscle functioning, leading to postural instability and increased falls risk. However, the link between impaired physical function, OA and falls have not been elucidated. We investigated the role of impaired physical function as a potential mediator in the association between OA and falls. This study included 389 participants [229 fallers (≥2 falls or one injurious fall in the past 12 months), 160 non-fallers (no history of falls)], age (≥65 years) from a randomized controlled trial, the Malaysian Falls Assessment and Intervention Trial (MyFAIT). Physical function was assessed using Timed Up and Go (TUG) and Functional Reach (FR) tests. Knee and hip OA were diagnosed using three methods: Clinical, Radiological and Self-report. OA symptom severity was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC). The total WOMAC score was categorized to asymptomatic, mild, moderate and severe symptoms. Individuals with radiological OA and 'mild' overall symptoms on the WOMAC score had reduced risk of falls compared to asymptomatic OA [OR: 0.402(0.172-0.940), p = 0.042]. Individuals with clinical OA and 'severe' overall symptoms had increased risk of falls compared to those with 'mild' OA [OR: 4.487(1.883-10.693), p = 0.005]. In individuals with radiological OA, mild symptoms appear protective of falls while those with clinical OA and severe symptoms have increased falls risk compared to those with mild symptoms. Both relationships between OA and falls were not mediated by physical limitations. Larger prospective studies are needed for further evaluation.
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For further information contact us at helpdesk@openaire.eu13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2010 CanadaHindawi Limited Authors: Margaret Fast; Kelly Bunzeluk;Margaret Fast; Kelly Bunzeluk;Antimicrobial resistance (AMR) in bacteria is the end result of a multitude of factors. Some of the key factors beyond innate resistance include antimicrobial selective pressure (1–5), acquisition of a foreign genetic resistance element(s) (1–5), clonal dissemination (1) and new mutations (2,3,5); factors vary for different species and geographical locations. Increased global antimicrobial use is the foremost reason for the spread of AMR in the community setting (1). Social networks of individuals (households, schools and child care facilities) have served both as a reservoir for these bacteria and as a common route for their transmission. Similarly, hospitals, nursing homes and long-term care facilities have also served as reservoirs for antibiotic-resistant organisms, and the discharge of patients from these facilities contributes to the spread of resistance within communities. In addition, the use of antimicrobials in food animals has been an important contributing cause (1). In the preantibiotic era, the mortality of patients infected with Staphylococcus aureus bacteremia exceeded 80%. Although the introduction of penicillin in the early 1940s significantly improved the prognosis of patients with staphylococcal infection, penicillin-resistant staphylococci were recognized within two years of its use (4,6). More than 80% of both community- and hospital-acquired staphylococcal isolates were resistant to penicillin by the late 1960s. This transfer of resistance, from the hospital setting to communities, is a well-established pattern that recurs with each new wave of AMR (6). For example, the introduction of methicillin in 1961 was quickly followed by reports of methicillin-resistant isolates in hospitals, and is now seen regularly in community-based infections (6). Health care-associated strains of methicillin-resistant S aureus (HA-MRSA) have been known to cause a wide variety of infections (eg, wound infections, catheter-associated bacteremias or prosthesis infections). Community-acquired MRSA (CA-MRSA) has emerged as the causative agent of serious individual cases and outbreaks of skin and soft tissue infections and sepsis. Infections have been noted among those without the usual HA-MRSA risk factors (history of hospitalization or other institutionalization, antibiotic use, dialysis and chronic wounds), and outbreaks have been reported in well-defined epidemiological groups (children in child care facilities, athletes, military recruits and prison inmates) (1,7). CA-MRSA is distinguished from HA-MRSA, in part, by the type of staphylococcal chromosomal cassette – a mobile chromosomal element that carries the methicillin resistance gene mec. However, there is a progressive blurring of the two categories. HA-MRSA is also disseminated in the community (for example, MRSA has been transmitted from hospital patients to their household contacts), and CA-MRSA has entered health care settings and caused outbreaks in hospitals (1). Vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing organisms that are resistant to ceph-alosporins and monobactams, and penicillin-resistant Streptococcus pneumoniae have also evolved through a combination of acquired foreign genetic material, antibiotic selective pressure and clonal dissemination (1). Vancomycin-resistant enterococci have been associated with the use of growth promoters in food animals, especially in Europe (1), and extended-spectrum beta-lactamase-producing Gram negatives, especially Klebsiella and Escherichia coli, have been increasingly noted as a source of community-acquired infections (8). Similarly, penicillin-resistant S pneumoniae, a common cause of otitis media, sinusitis, community-acquired pneumonia, meningitis and bacteremia, has emerged in the past few decades – first identified more than 20 years after the introduction of penicillin (1,8). Although the ultimate impact of AMR in the community is still uncertain, reducing the development and limiting the spread of resistant organisms should be a public health priority. The two most urgent proven strategies to effect this goal are to limit antimicrobial use to prevent selective pressure, and to enhance infection prevention and control practices, including basic hand hygiene, to prevent clonal dissemination (1,2,9,10). Several national and regional groups in Canada are currently investigating AMR issues, and numerous policy and practice guidance documents have been produced. Despite these efforts, public health leaders and practitioners across Canada have argued that knowledge and practice gaps still exist on the issue of AMR, particularly in community settings. With the assistance of an expert advisory group, the National Collaborating Centre for Infectious Diseases (NCCID) identified projects that could help reduce the burden of community-acquired AMR in Canada. The goal of one project was to describe population-level interventions to reduce the development and transmission of community-associated AMR. NCCID issued a call for proposals in the summer of 2008, and in the fall of 2008, a selection process was undertaken that included peer review by independent, external experts. Three proposals were selected for NCCID funding: Antimicrobial use and resistance in pigs and chickens: A review of the science, policy and control practices from farm to slaughter – Leigh B Rosengren, Sheryl P Gow and J Scott Weese. A review of alternative practices to antimicrobial use for disease control in the commercial feedlot – Carl S Ribble, Tyler Stitt, S Iwasawa, Lorraine Toews and Craig Stephen. Strategies to control community-associated antimicrobial resistance among enteric bacteria and methicillin-resistant Staphylococcus aureus in Canada – Jeff Wilson, John Conly, Thomas Wong, Gayatri Jayaraman, Jan Sargeant, Andrew Papadopoulos, Virginia Young, Melanie Quist-Moyer and Sharon Bauer. Drafts of the comprehensive reviews were read by a minimum of five independent reviewers. Feedback was compiled and provided to the authors for incorporation. The authors presented their general findings at a community-acquired AMR consultation hosted by the NCCID in February 2010. The consultation, which included 50 experts from human, animal and environmental health fields, allowed the reviews to be further refined. Proceedings from the consultation are available on the NCCID website (www.nccid.ca/en/caamr-consultation-feb10). The subsequent pages present the executive summaries of the three reviews (the full comprehensive reviews are available online at http://nccid.ca/en/amr-reviews). The first two reviews focus on antimicrobial use and resistance in animals raised for food, namely pigs and chickens (11) and cattle (12). The third review discusses strategies to control community-acquired AMR among human enteric bacteria and MRSA (7). It is hoped that these papers will lead to further discussion and research into the most effective strategies to reduce the development and spread of AMR.
MSpace at the Univer... arrow_drop_down MSpace at the University of Manitoba; Canadian Journal of Infectious Diseases and Medical MicrobiologyOther literature type . Article . 2010License: CC BYCanadian Journal of Infectious Diseases and Medical MicrobiologyArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert MSpace at the Univer... arrow_drop_down MSpace at the University of Manitoba; Canadian Journal of Infectious Diseases and Medical MicrobiologyOther literature type . Article . 2010License: CC BYCanadian Journal of Infectious Diseases and Medical MicrobiologyArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2016Informa UK Limited G, Remington; J, Lee; O, Agid; H, Takeuchi; G, Foussias; M, Hahn; G, Fervaha; L, Burton; V, Powell;pmid: 27207070
Clozapine was first introduced as an antipsychotic in the 1970's but a cluster of deaths, later linked to the drug's risk of agranulocytosis, led to its withdrawal in most countries. However, work in the 1980's established its unique efficacy in treatment resistant schizophrenia (TRS), which constitutes as many as 30% of those with the illness. Clozapine was reintroduced with this indication shortly thereafter, but because of this risk its use requires routine hematologic monitoring.An update is provided regarding clozapine's risk of neutropenia, agranulocytosis, and associated mortality. In addition, updates are provided on other side effects, specifically myocarditis and bowel obstruction, as evidence suggests these are more common than agranulocytosis and associated with higher mortality rates.Clozapine remains the only treatment indicated in TRS, but it is dramatically underutilized. Clearly there are serious side effects associated with its use, and while the focus has historically been on hematologic concerns, we highlight other side effects that also demand systematic monitoring. Because it is the only effective treatment option we have for TRS, though, efforts must be implemented that ensure its use in this population while maximizing safety.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu63 citations 63 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023Cold Spring Harbor Laboratory WTWTMarisa C. Hamilton; James D. Fife; Ersin Akinci; Tian Yu; Benyapa Khowpinitchai; Minsun Cha; Sammy Barkal; Thi Tun Thi; Grace H.T. Yeo; Juan Pablo Ramos Barroso; Matthew Jake Francoeur; Minja Velimirovic; David K. Gifford; Guillaume Lettre; Haojie Yu; Christopher A. Cassa; Richard I. Sherwood;pmc: PMC9881906 , PMC10203276
SummaryGenetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening, we have substantially improved the identification of genes whose disruption alters serum LDL-C levels. We identify 21 genes in which rare coding variants significantly alter LDL-C levels at least partially through altered LDL-C uptake. We use co-essentiality-based gene module analysis to show that dysfunction of the RAB10 vesicle transport pathway leads to hypercholesterolemia in humans and mice by impairing surface LDL receptor levels. Further, we demonstrate that loss of function ofOTX2leads to robust reduction in serum LDL-C levels in mice and humans by increasing cellular LDL-C uptake. Altogether, we present an integrated approach that improves our understanding of genetic regulators of LDL-C levels and provides a roadmap for further efforts to dissect complex human disease genetics.
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For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Conference object , Preprint 2019 FranceSpringer International Publishing Quentin Roy; Camelia Zakaria; Simon T. Perrault; Mathieu Nancel; Wonjung Kim; Archan Misra; Andy Cockburn;Part 8: Pointing, Touch, Gesture and Speech-Based Interaction Techniques; International audience; Eyewear displays allow users to interact with virtual content displayed over real-world vision, in active situations like standing and walking. Pointing techniques for eyewear displays have been proposed, but their social acceptability, efficiency, and situation awareness remain to be assessed. Using a novel street-walking simulator, we conducted an empirical study of target acquisition while standing and walking under different levels of street crowdedness. We evaluated three phone-based eyewear pointing techniques: indirect touch on a touchscreen, and two in-air techniques using relative device rotations around forward and a downward axes. Direct touch on a phone, without eyewear, was used as a control condition. Results showed that indirect touch was the most efficient and socially acceptable technique, and that in-air pointing was inefficient when walking. Interestingly, the eyewear displays did not improve situation awareness compared to the control condition. We discuss implications for eyewear interaction design.
https://hal.archives... arrow_drop_down https://hal.archives-ouvertes....Preprint . Part of book or chapter of bookLicense: CC BYData sources: UnpayWallhttps://doi.org/10.1007/978-3-...Part of book or chapter of book . 2019License: Springer Nature TDMData sources: CrossrefHAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYINRIA a CCSD electronic archive server; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-030-29387-1_36&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert https://hal.archives... arrow_drop_down https://hal.archives-ouvertes....Preprint . Part of book or chapter of bookLicense: CC BYData sources: UnpayWallhttps://doi.org/10.1007/978-3-...Part of book or chapter of book . 2019License: Springer Nature TDMData sources: CrossrefHAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYINRIA a CCSD electronic archive server; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationConference object . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1999Elsevier BV Authors: Lin, Zheng Yan; Choi, Yong-Kab;Lin, Zheng Yan; Choi, Yong-Kab;AbstractIn this paper we establish large increment results and moduli of continuty for a two-parameter fractional Lévy Brownian motion on rectangles in the Euclidean plane via estimating upper bounds of large deviation probabilities on suprema of the two-parameter fractional Lévy Brownian motion.
https://doi.org/10.1... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0304-4149(99)00019-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu16 citations 16 popularity Average influence Top 10% impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Report , Other literature type , Preprint 2018 Turkey, Italy, Italy, Germany, Portugal, Portugal, Italy, United Kingdom, Italy, Italy, Spain, Denmark, Italy, Poland, Italy, Italy, France, ItalySpringer Science and Business Media LLC Aaboud M.; Aad G.; Abbott B.; Abdinov O.; Abeloos B.; Abhayasinghe D. K.; Abidi S. H.; Abouzeid O. S.; Abraham N. L.; Abramowicz H.; Abreu H.; Abulaiti Y.; Acharya B. S.; Adachi S.; Adam L.; Adamczyk L.; Adelman J.; Adersberger M.; Adiguzel A.; Adye T.; Affolder A. A.; Afik Y.; Agheorghiesei C.; Aguilar-Saavedra J. A.; Ahmadov F.; Aielli G.; Akatsuka S.; Åkesson T. P. A.; Akilli E.; Akimov A. V.; Alberghi G. L.; Albert J.; Albicocco P.; Alconada Verzini M. J.; Alderweireldt S.; Aleksa M.; Aleksandrov I. N.; Alexa C.; Alexopoulos T.; Alhroob M.; Ali B.; Alimonti G.; Alison J.; Alkire S. P.; Allaire C.; Allbrooke B. M. M.; Allen B. W.; Allport P. P.; Aloisio A.; Alonso A.; Alonso F.; Alpigiani C.; Alshehri A. A.; Alstaty M. I.; Alvarez Gonzalez B.; Álvarez Piqueras D.; Alviggi M. G.; Amadio B. T.; Amaral Coutinho Y.; Ambler A.; Ambroz L.; Amelung C.; Amidei D.; Amor Dos Santos S. P.; Amoroso S.; Amrouche C. S.; Anastopoulos C.; Ancu L. S.; Andari N.; Andeen T.; Anders C. F.; Anders J. K.; Anderson K. J.; Andreazza A.; Andrei V.; Anelli C. R.; Angelidakis S.; Angelozzi I.; Angerami A.; Anisenkov A. V.; Annovi A.; Antel C.; Anthony M. T.; Antonelli M.; Antrim D. J. A.; Anulli F.; Aoki M.; Aparisi Pozo J. A.; Aperio Bella L.; Arabidze G.; Araque J. P.; Araujo Ferraz V.; Araujo Pereira R.; Arce A. T. H.; Ardell R. E.; Arduh F. A.; Arguin J. -F.; Argyropoulos S.; Armbruster A. J.; Armitage L. J.; Armstrong A.; Arnaez O.; Arnold H.; Arratia M.; Arslan O.; Artamonov A.; Artoni G.; Artz S.; Asai S.; Asbah N.; Asimakopoulou E. M.; Asquith L.; Assamagan K.; Astalos R.; Atkin R. J.; Atkinson M.; Atlay N. B.; Augsten K.; Avolio G.; Avramidou R.; Ayoub M. K.; Azuelos G.; Baas A. E.; Baca M. J.; Bachacou H.; Bachas K.; Backes M.; Bagnaia P.; Bahmani M.; Bahrasemani H.; Bailey A. J.; Baines J. T.; Bajic M.; Bakalis C.; Baker O. K.; Bakker P. J.; Bakshi Gupta D.; Balaji S.; Baldin E. M.; Balek P.; Balli F.; Balunas W. K.; Balz J.; Banas E.; Bandyopadhyay A.; Banerjee S.; Bannoura A. A. E.; Barak L.; Barbe W. M.; Barberio E. L.; Barberis D.; Barbero M.; Barillari T.; Barisits M. -S.; Barkeloo J.; Barklow T.; Barnea R.; Barnes S. L.; Barnett B. M.; Barnett R. M.; Barnovska-Blenessy Z.; Baroncelli A.; Barone G.; Barr A. J.; Barranco Navarro L.; Barreiro F.; Barreiro Guimarães da Costa J.; Bartoldus R.; Barton A. E.; Bartos P.; Basalaev A.; Bassalat A.; Bates R. L.; Batista S. J.; Batlamous S.; Batley J. R.; Battaglia M.; Bauce M.; Bauer F.; Bauer K. T.; Bawa H. S.; Beacham J. B.; Beau T.; Beauchemin P. H.; Bechtle P.; Beck H. C.; Beck H. P.; Becker K.; Becker M.; Becot C.; Beddall A.; Beddall A. J.; Bednyakov V. A.; Bedognetti M.; Bee C. P.; Beermann T. A.; Begalli M.; Begel M.; Behera A.; Behr J. K.; Bellagamba L.; Benchekroun D.; Benekos N.; Benjamin D. P.; Benoit M.; Berger N.; Beringer J.; Berta P.; Bessner M.; Besson N.; Bethani A.; Betti A.; Bevan A. J.; Bianchi R. M.; Biesuz N. V.; Billoud T. R. V.; Bindi M.; Biondi S.; Biswal J. P.; Blue A.; Bogavac D.; Bold T.; Bolz A. E.; Bona M.; Bortfeldt J.; Bosman M.; Bossio Sola J. D.; Bouaouda K.; Bouhova-Thacker E. V.; Boutle S. K.; Boveia A.; Brahimi N.; Brandt A.; Breaden Madden W. D.; Britton D.; Brooijmans G.; Brost E.; Broughton J. H.; Bruckman de Renstrom P. A.; Bruno S.; Bruscino N.; Buckley A. G.; Burdin S.; Burke S.; Buttar C. M.; Butterworth J. M.; Buzykaev A. R.; Cabras G.; Cai H.; Cairo V. M. M.; Cakir O.; Calafiura P.; Calandri A.; Callea G.; Calvente Lopez S.; Calvetti M.; Camarda S.; Camarri P.; Campoverde A.; Canale V.; Cantero J.; Capeans Garrido M. D. M.; Caprini I.; Caprini M.; Capua M.; Cardillo F. C.; Carli I.; Carquin E.; Carrá S.; Casado M. P.; Castillo F. L.; Castillo Gimenez V.; Castro N. F.; Caudron J.; Cavasinni V.; Cerda Alberich L.; Cerqueira A. S.; Cerri A.; Chargeishvili B.; Chelstowska M. A.; Chen C.; Chen C. H.; Chen H.; Cheng H. C.; Cheremushkina E.; Cherkaoui El Moursli R.; Chevalier L.; Chiarella V.; Chiodini G.; Chu M. C.; Chudoba J.; Chwastowski J. J.; Chytka L.; Cinca D.; Cindro V.; Citron Z. H.; Coadou Y.; Cobal M.; Coccaro A.; Coimbra A. E. C.; Colasurdo L.; Conde Muiño P.; Coniavitis E.; Corrigan E. E.; Corriveau F.; Costa M. J.; Costanzo D.; Cottin G.; Cranmer K.; Cristinziani M.; Croft V.; Crosetti G.; Cueto A.; Czodrowski P.; Dabrowski W.; Dado T.; Dahbi S.; Dallapiccola C.; Danninger M.; Dao V.; Darbo G.; Davey W.; David C.; Davidek T.; De Cecco S.; De la Torre H.; De Maria A.; De Sanctis U.; De Santis M.; De Vivie De Regie J. B.; Deliot F.; Delitzsch C. M.; Della Pietra M.; Dell’acqua A.; Delsart P. A.; Demarco D. A.; Derendarz D.; Dervan P.; Di Bello F. A.; Di Ciaccio A.; Di Ciaccio L.; Diaconu C.; Dias F. A.; Dias Do Vale T.; Dietrich J.; Dittus F.; Djama F.; Djobava T.; Doglioni C.; Doyle A. T.; Duckeck G.; Ducu O. A.; Duda D.; Duperrin A.; Duran Yildiz H.; Durglishvili A.; Dyndal M.; Dziedzic B. S.; Ellert M.; Ellinghaus F.; Ellis N.; Elsing M.; Erdmann J.; Ereditato A.; Escalier M.; Escobar C.; Estrada Pastor O.; Evans H.; Ezhilov A.; Ezzi M.; Fabbri F.; Fabiani V.; Faisca Rodrigues Pereira R. M.; Falke P. J.; Falke S.; Faltova J.; Fanti M.; Farbin A.; Farina E. M.; Farooque T.; Farrington S. M.; Fassi F.; Faucci Giannelli M.; Fawcett W. J.; Feligioni L.; Feng C.; Ferreira de Lima D. E.; Ferrere D.; Filthaut F.; Fiorini L.; Fisher W. C.; Fleck I.; Flores L. M.; Formica A.; Fox H.; Francavilla P.; Franchini M.; Franklin M.; Freund B.; Fullana Torregrosa E.; Gadow P.; Gagnon L. G.; Gamboa Goni R.; García Navarro J. E.; García Pascual J. A.; Gee C. N. P.; Genest M. H.; George S.; Ghneimat M.; Giagu S.; Giangiacomi N.; Giannetti P.; Gibson S. M.; Giordani M. P.; Giromini P.; Giugliarelli G.; Giuli F.; Gkaitatzis S.; Gkougkousis E. L.; Glasman C.; Glaysher P. C. F.; Godlewski J.; Golling T.; Gonçalo R.; Gonella G.; Gongadze A.; Gonski J. L.; González de la Hoz S.; Goossens L.; Govender N.; Grabowska-Bold I.; Gramstad E.; Grancagnolo S.; Gravila P. M.; Gravili F. G.; Gray C.; Grefe C.; Gregersen K.; Gregor I. M.; Grinstein S.; Groh S.; Grummer A.; Guenther J.; Guescini F.; Guo J.; Gustavino G.; Gutschow C.; Guzik M. P.; Gwenlan C.; Gwilliam C. B.; Haas A.; Hadavand H. K.; Hadef A.; Haley J.; Halladjian G.; Hamal P.; Han K.; Hanagaki K.; Handl D. M.; Haney B.; Hansen E.; Hansen J. B.; Hassani S.; Haug S.; Hays C. P.; Heath M. P.; Heelan L.; Heim S.; Heinrich J. J.; Heinrich L.; Heinz C.; Hejbal J.; Held A.; Herde H.; Hernández Jiménez Y.; Hill E.; Hillier S. J.; Hils M.; Hod N.; Holmes T. R.; Honda S.; Hopkins W. H.; Horn P.; Horyn L. A.; Hoya J.; Hrynevich A.; Hubaut F.; Hunter R. F. H.; Iacobucci G.; Iliadis D.; Introzzi G.; Ippolito V.; Isacson M. F.; Islam W.; Istin S.; Iuppa R.; Jackson P.; Jakobsen S.; Jakoubek T.; Jana D. K.; Jansky R.; Janssen J.; Jeanneau F.; Jeanty L.; Jia J.; Jiggins S.; Jinnouchi O.; Jon-And K.; Jones R. W. L.; Jones S. D.; Jones S.; Jorge P. M.; Jovicevic J.; Ju X.; Junggeburth J. J.; Juste Rozas A.; Kaczmarska A.; Kar D.; Karentzos E.; Karpov S. N.; Karpova Z. M.; Kay E. F.; Kazanin V. F.; Keeler R.; Kempster J. J.; Kendrick J.; Kharlamova T.; Khoo T. J.; Khramov E.; Kirk J.; Kiryunin A. E.; Klimek P.; Knue A.; Kodys P.; Koffas T.; König A. C.; Kono T.; Konoplich R.; Konstantinidis N.; Korcyl K.; Koulouris A.; Kourkoumelis C.; Kourlitis E.; Kouskoura V.; Kowalewski R.; Krasnopevtsev D.; Krauss D.; Kretzschmar J.; Kroll J.; Kruchonak U.; Kugel A.; Kukla R.; Kulchitsky Y.; Kupco A.; Kurchaninov L. L.; Kuwertz E. S.; Kuze M.; La Rosa A.; La Rosa Navarro J. L.; La Rotonda L.; Lacasta C.; Lafaye R.; Landon M. P. J.; Lange J. C.; Lapertosa A.; Lari T.; Lassnig M.; Lazzaroni M.; Leblanc M.; Lee C. A.; Lee G. R.; Lefebvre B.; Legger F.; Leight W. A.; Leisos A.; Leite M. A. L.; Leney K. J. C.; Leone R.; Leonidopoulos C.; Leroy C.; Les R.; Lester C. G.; Levchenko M.; Li B.; Li H.; Lie K.; Lin C. Y.; Lipniacka A.; Lisovyi M.; Lister A.; Litke A. M.; Little J. D.; Liu B.; Liu B. L.; Liu H. B.; Liu H.; Livan M.; Lleres A.; Llorente Merino J.; Lloyd S. L.; Lobodzinska E. M.; Loch P.; Lohwasser K.; Lokajicek M.; Longo L.; Lopez J. A.; Lorenzo Martinez N.; Losada M.; Lozano Bahilo J. J.; Luci C.; Lucotte A.; Luehring F.; Lysak R.; Macdonald C. M.; Madar R.; Madysa N.; Maeda J.; Maevskiy A. S.; Majersky O.; Makida Y.; Makovec N.; Maleev V. P.; Mamuzic J.; Mancini G.; Maneira J.; Manjarres Ramos J.; Mankinen K. H.; Manousos A.; Manzoni S.; March L.; Marcisovsky M.; Marjanovic M.; Marti-Garcia S.; Martin C. B.; Martin T. A.; Martin V. J.; Martin-Haugh S.; Marzin A.; Masetti L.; Massa L.; Massarotti P.; Mastrandrea P.; Mastroberardino A.; Masubuchi T.; Mazza S. M.; McLean K. D.; McNamara P. C.; McPherson R. A.; Meirose B.; Mellado Garcia B. R.; Mellenthin J. D.; Melo M.; Meloni F.; Mendes Gouveia E. D.; Mengarelli A.; Meoni E.; Messina A.; Mete A. S.; Mijović L.; Mikestikova M.; Millar D. A.; Mindur B.; Mistry K. P.; Mkrtchyan T.; Mogg P.; Mohapatra S.; Monk J.; Montejo Berlingen J.; Monzani S.; Morange N.; Moreno D.; Morettini P.; Morii M.; Morley A. K.; Morvaj L.; Moyse E. J. W.; Mueller F.; Mullier G. A.; Munoz Sanchez F. J.; Murray W. J.; Murrone A.; Nagasaka Y.; Nairz A. M.; Nanjo H.; Napolitano F.; Naryshkin I.; Neep T. J.; Negrini M.; Nelson M. E.; Nemecek S.; Nielsen D. S.; Nikiforou N.; Nikolopoulos K.; Nisati A.; Nishu N.; Nobe T.; Novak T.; Ntekas K.; Ocariz J.; Ochoa-Ricoux J. P.; Oda S.; Ohm C. C.; Oide H.; Okazaki Y.; Oliveira Damazio D.; Oliver J. L.; Olszewski A.; Olszowska J.; Onofre A.; Onyisi P. U. E.; Oreglia M. J.; Orestano D.; Orlando N.; Ould-Saada F.; Ozturk N.; Pachal K.; Pacheco Pages A.; Padilla Aranda C.; Palestini S.; Palka M.; Panduro Vazquez J. G.; Panizzo G.; Pasuwan P.; Pathak A.; Pedro R.; Peleganchuk S. V.; Penc O.; Perini L.; Peters K.; Petersen B. A.; Petrucci F.; Pezoa R.; Pham T.; Pianori E.; Pilkington A. D.; Pleskot V.; Poggi R.; Policicchio A.; Pollard C. S.; Ponomarenko D.; Potter C. J.; Potti H.; Poulsen T.; Poveda J.; Pralavorio P.; Primavera M.; Prince S.; Proklova N.; Prokoshin F.; Przybycien M.; Puri A.; Qian J.; Queitsch-Maitland M.; Ragusa F.; Raine J. A.; Rauch D. M.; Ravina B.; Reale M.; Rebuzzi D. M.; Redlinger G.; Reeves K.; Reichert J.; Resconi S.; Resseguie E. D.; Ricci E.; Ridel M.; Rieck P.; Rifki O.; Rimoldi A.; Ripellino G.; Rivera Vergara J. C.; Roberts R. T.; Robinson D.; Robson A.; Rocco E.; Roda C.; Rodriguez Bosca S.; Rodriguez Perez A.; Roland C. P. A.; Roloff J.; Romaniouk A.; Romano M.; Rompotis N.; Roos L.; Rosati S.; Rosbach K.; Rotaru M.; Roy D.; Rozen Y.; Rurikova Z.; Russell H. L.; Ryu S.; Ryzhov A.; Sabatini P.; Saimpert M.; Saito M.; Salazar Loyola J. E.; Salvatore D.; Salvucci A.; Sammel D.; Sanchez Pineda A.; Sankey D. P. C.; Santra A.; Sasaki O.; Sato K.; Sauvan E.; Sawyer C.; Schaefer D.; Schildgen L. K.; Schioppa E. J.; Schioppa M.; Schmidt-Sommerfeld K. R.; Schmitt C.; Schmitt S.; Schoeffel L.; Schopf E.; Schouwenberg J. F. P.; Schramm S.; Schwarz T. A.; Sciandra A.; Scornajenghi M.; Scyboz L. M.; Searcy J.; Sebastiani C. D.; Senkin S.; Serkin L.; Sessa M.; Sforza F.; Sfyrla A.; Shabalina E.; Shahinian J. D.; Shaikh N. W.; Shapiro M.; Sharma A. S.; Shi L.; Shimojima M.; Shojaii S.; Simioni E.; Simon M.; Sioli M.; Siral I.; Sliwa K.; Smirnov N.; Smirnov S. Y.; Smirnov Y.; Smirnova L. N.; Smith J. W.; Smolek K.; Smykiewicz A.; Snyder I. M.; Solovyev V.; Sommer P.; Son H.; Song W.; Sopczak A.; Sotiropoulou C. L.; Soualah R.; Sowden B. C.; Spagnolo S.; Spieker T. M.; Stabile A.; Stanecka E.; Stanislaus B.; Stark G. H.; Starovoitov P.; Stärz S.; Staszewski R.; Stevenson T. J.; Stolte P.; Straessner A.; Strandberg J.; Strizenec P.; Stucci S. A.; Stugu B.; Stupak J.; Sullivan M. J.; Sumida T.; Svatos M.; Swiatlowski M.; Sykora I.; Ta D.; Tahirovic E.; Takai H.; Tapia Araya S.; Tartarelli G. F.; Tassi E.; Taylor A. C.; Taylor A. J.; Terashi K.; Terron J.; Terzo S.; Thiele F.; Thompson A. S.; Thomson E.; Tian Y.; Ticse Torres R. E.; Tikhomirov V. O; Tisserant S.; Tokushuku K.; Tomiwa K. G.; Torró Pastor E.; Toth J.; Trigger I. M.; Trincaz-Duvoid S.; Trocmé B.; Trofymov A.; Troncon C.; Trovato F.; Truong L.; Trzebinski M.; Tsai F.; Tsuno S.; Tu Y.; Tudorache A.; Tudorache V.; Turra R.; Tzovara E.; Ughetto M.; Unal G.; Ungaro F. C.; Urquijo P.; Vadla K. O. H.; Vaidya A.; Valente M.; Valero A.; Valéry L.; Van Daalen T. R.; Van Gemmeren P.; Van Vulpen I.; Vanadia M.; Vari R.; Varvell K. E.; Vazquez Furelos D.; Veloso F.; Veneziano S.; Ventura A.; Vercesi V.; Verducci M.; Vermeulen A. T.; Vetterli M. C.; Viaux Maira N.; Vickey T.; Vickey Boeriu O. E.; Villa M.; Vincter M. G.; Vivarelli I.; Vlachos S.; von Buddenbrock S. E.; Vorobel V.; Vos M.; Vranjes N.; Vranjes Milosavljevic M.; Vukotic I.; Walder J.; Walkowiak W.; Wang A. M.; Wang C.; Wanotayaroj C.; Warburton A.; Wardrope D. R.; Watkins P. M.; Watts G.; Weber C.; Weber M. S.; Weber S. A.; Weingarten J.; Weirich M.; Weiser C.; Wenaus T.; Wengler T.; Werner M. D.; Werner P.; Whalen K.; Wickens F. J.; Wielers M.; Wiglesworth C.; Willocq S.; Winkels E.; Winklmeier F.; Winter B. T.; Wolf A.; Wolter M. W.; Wolters H.; Worm S. D.; Woźniak K. W.; Wu M.; Wu S. L.; Wu X.; Xella S.; Xi Z.; Xu D.; Xu H.; Yabsley B.; Yacoob S.; Yamaguchi D.; Yamazaki T.; Yang H. J.; Yang H. T.; Yap Y. C.; Yigitbasi E.; Yorita K.; Yu J.; Zaidan R.; Zakareishvili T.; Zakharchuk N.; Zanzi D.; Zhang D. F.; Zhang D.; Zhang F.; Zhao P.; Zhemchugov A.; Zhou B.; Zhu C. G.; Zoch K.; Zorbas T. G.;We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5
CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 30visibility views 30 download downloads 50 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013Wiley Danielle M. Frechette; Alison L. Collins; James T. Harvey; Sean A. Hayes; David D. Huff; Andrew W. Jones; Nicolas A. Retford; Alina E. Langford; Jonathan W. Moore; Ann-Marie K. Osterback; William H. Satterthwaite; Scott A. Shaffer;AbstractAvian predation on juvenile salmonids is an important source of mortality in freshwater and estuarine habitats when birds and salmonids overlap spatially and temporally. We assessed the potential impact of avian predation upon juvenile steelhead Oncorhynchus mykiss in a coastal watershed in central California. We conducted stream surveys between 2008 and 2010 to determine the composition, distribution, and density of piscivorous birds in areas that provide rearing habitat for juvenile steelhead. The most commonly sighted bird species were common mergansers Mergus merganser and belted kingfishers Megacyrle alcyon. The density of avian predators varied spatially and temporally but was greatest in the estuary regardless of season and decreased with increasing distance from the estuary. In the absence of local predator diet data, we applied a bioenergetics model to estimate the potential predation on juvenile steelhead by mergansers and kingfishers in the Scott Creek estuary. Model parameters included (1) published values of bird energetic requirements and steelhead energy density, (2) the number of birds present in the estuary during the closure period (from stream surveys), and (3) the size frequency and abundance of steelhead present in the estuary during closure. We predicted the extent of predation for different values of steelhead in bird diets, accounting for uncertainty in the estimates using a Monte Carlo simulation approach. With the assumed contribution of steelhead to the diet ranging from 20% to 100%, the population of kingfishers foraging in the Scott Creek estuary had the potential to remove 3–17% of annual production, whereas mergansers had the potential to remove 5–54% of annual steelhead production. Our results suggest that predation by avian species, particularly mergansers, is an important source of mortality for threatened steelhead populations in central California and should be addressed in future salmonid research and recovery planning.Received February 13, 2013; accepted June 4, 2013
North American Journ... arrow_drop_down North American Journal of Fisheries ManagementArticle . 2013License: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Average influence Average impulse Average Powered by BIP!more_vert North American Journ... arrow_drop_down North American Journal of Fisheries ManagementArticle . 2013License: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021American Society of Clinical Oncology (ASCO) Jorge E. Cortes; Jane F. Apperley; Elza Lomaia; Beatriz Moiraghi; Maria Undurraga Sutton; Carolina Pavlovsky; Charles Chuah; Tomasz Sacha; Jeffrey H. Lipton; Charles A. Schiffer; James K. McCloskey; Andreas Hochhaus; Philippe Rousselot; Gianantonio Rosti; Hugues de Lavallade; Michael J. Mauro; Tracey Hall; Vickie Lu; Shouryadeep Srivastava; Michael W. Deininger;7000 Background: PON, a third-generation tyrosine kinase inhibitor (TKI), demonstrated deep and long-lasting responses and survival in patients (pts) with chronic-phase chronic myeloid leukemia (CP-CML) resistant/intolerant to second-generation TKI therapy (PACE; NCT01207440); post hoc analysis suggested a relationship between dose and both adverse events and response. Here we present the primary analysis of OPTIC (NCT02467270), an ongoing, randomized, phase 2 trial with a novel response-based dosing regimen of PON in pts with resistant/intolerant CP-CML. Methods: Pts with CP-CML resistant/intolerant to ≥2 TKIs or with the BCR-ABL1 T315I mutation were randomized to PON starting doses of 45 mg (cohort A; 45 mg → 15 mg), 30 mg (B; 30 mg →15 mg), and 15 mg (C) once daily. Doses were reduced to 15 mg with achievement of ≤1% BCR-ABL1IS in cohorts A and B. The primary endpoint is ≤1% BCR-ABL1IS at 12 mo; secondary endpoints include cytogenetic and molecular responses and safety outcomes. AOEs were adjudicated prospectively by an independent review committee. Results: 283 pts were randomized (A/B/C: n=94/95/94) and had the following baseline characteristics: median age 48 y (18‒81 y); 98% received ≥2 (55% ≥3) TKIs; 99% had resistant disease; 40% had ≥1 baseline mutations (23% T315I). At the primary analysis with 32 mo median follow-up, 134 pts (47%; n=50/41/43) remained on treatment and 204 pts (72%) had PON exposure ≥12 mo. At 12 mo, 44% (41/93) in A, 29% (27/93) in B, and 23% (21/91) in C achieved ≤1% BCR-ABL1IS (Table); primary endpoint was met by cohort A. Dose reductions to 15 mg after achieving response (A/B) were 48/29%. Most common grades ≥3 TEAEs were thrombocytopenia, 27%; neutropenia, 17%; and anemia, 7%. AOEs/serious AOEs were reported in cohorts A (10%/4%), B (5%/4%), and C (3%/3%). Dose reductions or discontinuations for TEAEs (A/B/C) were 46/35/32% and 19/16/14%, respectively. Conclusions: The OPTIC primary analysis demonstrates the optimal benefit:risk profile for PON was achieved with a response-based dosing regimen starting with 45 mg/d, followed by dose reduction to 15 mg/d upon achieving ≤ 1% BCR-ABL1IS; 30 mg→15 mg and 15 mg cohorts may provide benefit, especially in pts without T315I mutation (Table). The observed ≤1% BCR-ABL1IS responses are supported by robust survival outcomes in pts with CP-CML resistant to second-generation BCR-ABL1 TKI therapy, both with and without BCR-ABL1 mutations. Clinical trial information: NCT02467270. [Table: see text]
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2021.39.15_suppl.7000&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2021.39.15_suppl.7000&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015Public Library of Science (PLoS) Sumaiyah Mat; Pey June Tan; Chin Teck Ng; Farhana Fadzli; Faizatul I Rozalli; Ee Ming Khoo; Keith D Hill; Maw Pin Tan;Osteoarthritis (OA) exacerbates skeletal muscle functioning, leading to postural instability and increased falls risk. However, the link between impaired physical function, OA and falls have not been elucidated. We investigated the role of impaired physical function as a potential mediator in the association between OA and falls. This study included 389 participants [229 fallers (≥2 falls or one injurious fall in the past 12 months), 160 non-fallers (no history of falls)], age (≥65 years) from a randomized controlled trial, the Malaysian Falls Assessment and Intervention Trial (MyFAIT). Physical function was assessed using Timed Up and Go (TUG) and Functional Reach (FR) tests. Knee and hip OA were diagnosed using three methods: Clinical, Radiological and Self-report. OA symptom severity was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC). The total WOMAC score was categorized to asymptomatic, mild, moderate and severe symptoms. Individuals with radiological OA and 'mild' overall symptoms on the WOMAC score had reduced risk of falls compared to asymptomatic OA [OR: 0.402(0.172-0.940), p = 0.042]. Individuals with clinical OA and 'severe' overall symptoms had increased risk of falls compared to those with 'mild' OA [OR: 4.487(1.883-10.693), p = 0.005]. In individuals with radiological OA, mild symptoms appear protective of falls while those with clinical OA and severe symptoms have increased falls risk compared to those with mild symptoms. Both relationships between OA and falls were not mediated by physical limitations. Larger prospective studies are needed for further evaluation.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0141368&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0141368&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2010 CanadaHindawi Limited Authors: Margaret Fast; Kelly Bunzeluk;Margaret Fast; Kelly Bunzeluk;Antimicrobial resistance (AMR) in bacteria is the end result of a multitude of factors. Some of the key factors beyond innate resistance include antimicrobial selective pressure (1–5), acquisition of a foreign genetic resistance element(s) (1–5), clonal dissemination (1) and new mutations (2,3,5); factors vary for different species and geographical locations. Increased global antimicrobial use is the foremost reason for the spread of AMR in the community setting (1). Social networks of individuals (households, schools and child care facilities) have served both as a reservoir for these bacteria and as a common route for their transmission. Similarly, hospitals, nursing homes and long-term care facilities have also served as reservoirs for antibiotic-resistant organisms, and the discharge of patients from these facilities contributes to the spread of resistance within communities. In addition, the use of antimicrobials in food animals has been an important contributing cause (1). In the preantibiotic era, the mortality of patients infected with Staphylococcus aureus bacteremia exceeded 80%. Although the introduction of penicillin in the early 1940s significantly improved the prognosis of patients with staphylococcal infection, penicillin-resistant staphylococci were recognized within two years of its use (4,6). More than 80% of both community- and hospital-acquired staphylococcal isolates were resistant to penicillin by the late 1960s. This transfer of resistance, from the hospital setting to communities, is a well-established pattern that recurs with each new wave of AMR (6). For example, the introduction of methicillin in 1961 was quickly followed by reports of methicillin-resistant isolates in hospitals, and is now seen regularly in community-based infections (6). Health care-associated strains of methicillin-resistant S aureus (HA-MRSA) have been known to cause a wide variety of infections (eg, wound infections, catheter-associated bacteremias or prosthesis infections). Community-acquired MRSA (CA-MRSA) has emerged as the causative agent of serious individual cases and outbreaks of skin and soft tissue infections and sepsis. Infections have been noted among those without the usual HA-MRSA risk factors (history of hospitalization or other institutionalization, antibiotic use, dialysis and chronic wounds), and outbreaks have been reported in well-defined epidemiological groups (children in child care facilities, athletes, military recruits and prison inmates) (1,7). CA-MRSA is distinguished from HA-MRSA, in part, by the type of staphylococcal chromosomal cassette – a mobile chromosomal element that carries the methicillin resistance gene mec. However, there is a progressive blurring of the two categories. HA-MRSA is also disseminated in the community (for example, MRSA has been transmitted from hospital patients to their household contacts), and CA-MRSA has entered health care settings and caused outbreaks in hospitals (1). Vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing organisms that are resistant to ceph-alosporins and monobactams, and penicillin-resistant Streptococcus pneumoniae have also evolved through a combination of acquired foreign genetic material, antibiotic selective pressure and clonal dissemination (1). Vancomycin-resistant enterococci have been associated with the use of growth promoters in food animals, especially in Europe (1), and extended-spectrum beta-lactamase-producing Gram negatives, especially Klebsiella and Escherichia coli, have been increasingly noted as a source of community-acquired infections (8). Similarly, penicillin-resistant S pneumoniae, a common cause of otitis media, sinusitis, community-acquired pneumonia, meningitis and bacteremia, has emerged in the past few decades – first identified more than 20 years after the introduction of penicillin (1,8). Although the ultimate impact of AMR in the community is still uncertain, reducing the development and limiting the spread of resistant organisms should be a public health priority. The two most urgent proven strategies to effect this goal are to limit antimicrobial use to prevent selective pressure, and to enhance infection prevention and control practices, including basic hand hygiene, to prevent clonal dissemination (1,2,9,10). Several national and regional groups in Canada are currently investigating AMR issues, and numerous policy and practice guidance documents have been produced. Despite these efforts, public health leaders and practitioners across Canada have argued that knowledge and practice gaps still exist on the issue of AMR, particularly in community settings. With the assistance of an expert advisory group, the National Collaborating Centre for Infectious Diseases (NCCID) identified projects that could help reduce the burden of community-acquired AMR in Canada. The goal of one project was to describe population-level interventions to reduce the development and transmission of community-associated AMR. NCCID issued a call for proposals in the summer of 2008, and in the fall of 2008, a selection process was undertaken that included peer review by independent, external experts. Three proposals were selected for NCCID funding: Antimicrobial use and resistance in pigs and chickens: A review of the science, policy and control practices from farm to slaughter – Leigh B Rosengren, Sheryl P Gow and J Scott Weese. A review of alternative practices to antimicrobial use for disease control in the commercial feedlot – Carl S Ribble, Tyler Stitt, S Iwasawa, Lorraine Toews and Craig Stephen. Strategies to control community-associated antimicrobial resistance among enteric bacteria and methicillin-resistant Staphylococcus aureus in Canada – Jeff Wilson, John Conly, Thomas Wong, Gayatri Jayaraman, Jan Sargeant, Andrew Papadopoulos, Virginia Young, Melanie Quist-Moyer and Sharon Bauer. Drafts of the comprehensive reviews were read by a minimum of five independent reviewers. Feedback was compiled and provided to the authors for incorporation. The authors presented their general findings at a community-acquired AMR consultation hosted by the NCCID in February 2010. The consultation, which included 50 experts from human, animal and environmental health fields, allowed the reviews to be further refined. Proceedings from the consultation are available on the NCCID website (www.nccid.ca/en/caamr-consultation-feb10). The subsequent pages present the executive summaries of the three reviews (the full comprehensive reviews are available online at http://nccid.ca/en/amr-reviews). The first two reviews focus on antimicrobial use and resistance in animals raised for food, namely pigs and chickens (11) and cattle (12). The third review discusses strategies to control community-acquired AMR among human enteric bacteria and MRSA (7). It is hoped that these papers will lead to further discussion and research into the most effective strategies to reduce the development and spread of AMR.
MSpace at the Univer... arrow_drop_down MSpace at the University of Manitoba; Canadian Journal of Infectious Diseases and Medical MicrobiologyOther literature type . Article . 2010License: CC BYCanadian Journal of Infectious Diseases and Medical MicrobiologyArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1155/2010/930865&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert MSpace at the Univer... arrow_drop_down MSpace at the University of Manitoba; Canadian Journal of Infectious Diseases and Medical MicrobiologyOther literature type . Article . 2010License: CC BYCanadian Journal of Infectious Diseases and Medical MicrobiologyArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1155/2010/930865&type=result"></script>'); --> </script>
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