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description Publicationkeyboard_double_arrow_right Article , Other literature type 2013 Italy, Ireland, United Kingdom, Netherlands, United KingdomSpringer Science and Business Media LLC WT, EC | COGS, NIH | Characterizing Genetic Su... +6 projectsWT ,EC| COGS ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer: The BPC3. ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer;the BPC3 ,NIH| Genetic epidemiology of cell division regulation in breast cancer ,NIH| Breast &Prostate Cancer &Hormone-related Gene Variants ,NIH| Breast &prostate cancer &hormone-related gene variants ,NIH| Discovery Expansion and Replication ,CIHRAuthors: Montserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; +212 AuthorsMontserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Nick Orr; Suhn K. Rhie; Elio Riboli; Heather Spencer Feigelson; Diana Eccles; Hiltrud Brauch; Jane Carpenter; Heli Nevanlinna; Graham G. Giles; Angela Cox; John L. Hopper; Manjeet K. Bolla; Qin Wang; Joe Dennis; William J. Howat; Nils Schoof; Stig E. Bojesen; Diether Lambrechts; Irene L. Andrulis; Pascal Guénel; Antoinette Hollestelle; Olivia Fletcher; Robert Winqvist; Hermann Brenner; Alfons Meindl; Annika Lindblom; Peter Devillee; Mark S. Goldberg; Jan Lubinski; Vessela N. Kristensen; Anthony J. Swerdlow; Thilo Dörk; Keitaro Matsuo; Anna H. Wu; Paolo Radice; Soo Hwang Teo; William Blot; Daehee Kang; Mikael Hartman; Suleeporn Sangrajrang; Chen-Yang Shen; Melissa C. Southey; Fleur Hammet; Jennifer Stone; Emiel J. Th. Rutgers; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Michael G. Schrauder; Arif B. Ekici; Matthias W. Beckmann; Isabel dos Santos Silva; Nichola Johnson; Ian Tomlinson; Michael J. Kerin; Federick Marme; Andreas Schneeweiss; Thérèse Truong; Pierre Laurent-Puig; Pierre Kerbrat; Børge G. Nordestgaard; Sune F. Nielsen; Henrik Flyger; Roger L. Milne; Jose Ignacio Arias Perez; Primitiva Menéndez; Heiko Müller; Volker Arndt; Taru A. Muranen; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Tuomas Heikkinen; Hidemi Ito; Hiroji Iwata; Yasushi Yatabe; Natalia Antonenkova; Sara Margolin; Vesa Kataja; Veli-Matti Kosma; Jaana M. Hartikainen; Rosemary L. Balleine; Chiu-Chen Tseng; Patrick Neven; Anne Sophie Dieudonne; Anja Rudolph; Stefan Nickels; Dieter Flesch-Janys; Paolo Peterlongo; Bernard Peissel; Loris Bernard; Janet E. Olson; Xianshu Wang; Gianluca Severi; Laura Baglietto; Catriona McLean; Gerhard A. Coetzee; Ye Feng; Brian E. Henderson; Fredrick R. Schumacher; Natalia Bogdanova; Cheng Har Yip; Nur Aishah Taib; Martha J. Shrubsole; Jirong Long; Katri Pylkäs; Julia A. Knight; Gord Glendon; Anna Marie Mulligan; R.A.E.M. Tollenaar; Caroline M. Seynaeve; Mieke Kriege; Maartje J. Hooning; Ans M.W. van den Ouweland; Yu Tang Gao; Hui Cai; Sabapathy P. Balasubramanian; Simon S. Cross; Malcolm W.R. Reed; Lisa B. Signorello; Qiuyin Cai; Mitul Shah; Ching Wan Chan; Kee Seng Chia; Anna Jakubowska; Katarzyna Jaworska; Katarzyna Durda; Pei Ei Wu; Jyh Cherng Yu; Michael Jones; Daniel C. Tessier; Anna González-Neira; Guillermo Pita; M. Rosario Alonso; Daniel Vincent; Francois Bacot; Elisa V. Bandera; Esther M. John; Gary K. Chen; Jennifer J. Hu; Jorge L. Rodriguez-Gil; Leslie Bernstein; Michael F. Press; Regina G. Ziegler; Robert M. Millikan; Sandra Deming-Halverson; Sue A. Ingles; Quinten Waisfisz; Helen Tsimiklis; Enes Makalic; Daniel F. Schmidt; Minh Bui; Lorna Gibson; Bertram Müller-Myhsok; Rita K. Schmutzler; Rebecca Hein; Norbert Dahmen; Lars Beckmann; Kamila Czene; Astrid Irwanto; Clare Turnbull; Nazneen Rahman; André G. Uitterlinden; Fernando Rivadeneira; Curtis Olswold; Susan L. Slager; Robert Pilarski; Foluso O. Ademuyiwa; Irene Konstantopoulou; Nicholas G. Martin; Grant W. Montgomery; Dennis J. Slamon; Claudia Rauh; Michael P. Lux; Sebastian M. Jud; Priyanka Sharma; William J. Tapper; Sue Gerty; Dimitrios Trichopoulos; Rosario Tumino; Petra H.M. Peeters; Rudolf Kaaks; Daniele Campa; Federico Canzian; Elisabete Weiderpass; Mattias Johansson; Kay-Tee Khaw; Ruth C. Travis; Françoise Clavel-Chapelon; Laurence N. Kolonel; Constance Chen; Andrew H. Beck; Susan E. Hankinson; Robert N. Hoover; Jolanta Lissowska; Jonine D. Figueroa; Daniel I. Chasman; Mia M. Gaudet; W. Ryan Diver; Walter C. Willett; Jacques Simard; Javier Benitez; Alison M. Dunning; Mark E. Sherman; Georgia Chenevix-Trench; Stephen J. Chanock; Per Hall; Paul D.P. Pharoah; Douglas F. Easton; Christopher A. Haiman; Peter Kraft;Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
Nature Genetics; Oxf... arrow_drop_down Nature Genetics; Oxford University Research Archive; Archivio della Ricerca - Università di Pisa; The University of Manchester - Institutional Repository; NARCISOther literature type . Article . 2013 . 2016License: Springer TDMData sources: European Union Open Data Portal; Oxford University Research Archive; Erasmus University Rotterdam - Research Information Portal; Archivio della Ricerca - Università di Pisa; Crossref; SESAM Publication Database - FP7 HEALTH; The University of Manchester - Institutional Repository; NARCISArchivio della Ricerca - Università di PisaArticle . 2013Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu394 citations 394 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 17visibility views 17 download downloads 132 Powered bymore_vert Nature Genetics; Oxf... arrow_drop_down Nature Genetics; Oxford University Research Archive; Archivio della Ricerca - Università di Pisa; The University of Manchester - Institutional Repository; NARCISOther literature type . Article . 2013 . 2016License: Springer TDMData sources: European Union Open Data Portal; Oxford University Research Archive; Erasmus University Rotterdam - Research Information Portal; Archivio della Ricerca - Università di Pisa; Crossref; SESAM Publication Database - FP7 HEALTH; The University of Manchester - Institutional Repository; NARCISArchivio della Ricerca - Università di PisaArticle . 2013Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2009 Denmark, Italy, Netherlands, United KingdomElsevier BV WTWTBarry A. Chioza; Jean Aicardi; Harald N. Aschauer; Oebele F. Brouwer; Petra M.C. Callenbach; Athanasios Covanis; Joseph M. Dooley; Olivier Dulac; Martina Durner; Orvar Eeg-Olofsson; Martha Feucht; M. L. Friis; Renzo Guerrini; Marianne J. Kjeldsen; Rima Nabbout; Lina Nashef; Thomas Sander; Auli Siren; Elaine C. Wirrell; Paul M. McKeigue; Robert Robinson; R. Mark Gardiner; Kate V. Everett;pmid: 19837565
pmc: PMC2791882
Childhood absence epilepsy (CAE) is an idiopathic generalised epilepsy (IGE) characterised by typical absence seizures manifested by transitory loss of awareness with 2.5-4 Hz spike-wave complexes on ictal EEG. A genetic component to the aetiology is well recognised but the mechanism of inheritance and the genes involved are yet to be fully established. A genome wide single nucleotide polymorphism (SNP)-based high density linkage scan was carried out using 41 nuclear pedigrees with at least two affected members. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1 and a susceptibility locus was identified on chromosome 3p23-p14 (Z(mean)=3.9, p<0.0001; HLOD=3.3, alpha=0.7). The linked region harbours the functional candidate genes TRAK1 and CACNA2D2. Fine-mapping using a tagSNP approach demonstrated disease association with variants in TRAK1. Udgivelsesdato: 2009-Dec
Europe PubMed Centra... arrow_drop_down University of Southern Denmark Research OutputArticle . 2009Data sources: University of Southern Denmark Research Outputadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 30 Powered bymore_vert Europe PubMed Centra... arrow_drop_down University of Southern Denmark Research OutputArticle . 2009Data sources: University of Southern Denmark Research Outputadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2013 France, CroatiaElsevier BV NIH | Novel genetics, pathobiol..., WT, NIH | Identifying all Meckel-li... +4 projectsNIH| Novel genetics, pathobiology and therapy of nephronophthisis-related ciliopathies ,WT ,NIH| Identifying all Meckel-like ciliopathy genes by established total exome capture a ,EC| SYSCILIA ,NIH| Pathogenesis of PCD Lung Disease ,NIH| Colorado Clinical and Translational Science Institute (UL1) ,NIH| Genetic Disorder of Mucocilary ClearanceAuthors: Maimoona A. Zariwala; Heon Yung Gee; Małgorzata Kurkowiak; Dalal A. Al-Mutairi; +54 AuthorsMaimoona A. Zariwala; Heon Yung Gee; Małgorzata Kurkowiak; Dalal A. Al-Mutairi; Margaret W. Leigh; Toby W. Hurd; Rim Hjeij; Sharon D. Dell; Moumita Chaki; Gerard W. Dougherty; Mohamed Adan; Philip C. Spear; Julian Esteve-Rudd; Niki T. Loges; Margaret Rosenfeld; Katrina A. Diaz; Heike Olbrich; Whitney E. Wolf; Eamonn Sheridan; Trevor F.C. Batten; Jan Halbritter; Jonathan D. Porath; Stefan Kohl; Svjetlana Lovric; Daw Yang Hwang; Jessica E. Pittman; Kimberlie A. Burns; Thomas W. Ferkol; Scott D. Sagel; Kenneth N. Olivier; Lucy Morgan; Claudius Werner; Johanna Raidt; Petra Pennekamp; Zhaoxia Sun; Weibin Zhou; Rannar Airik; Sivakumar Natarajan; Susan J. Allen; Israel Amirav; Dagmar Wieczorek; Kerstin Landwehr; Kim G. Nielsen; Nicolaus Schwerk; Jadranka Sertić; Gabriele Köhler; Joseph Washburn; Shawn Levy; Shuling Fan; Cordula Koerner-Rettberg; Serge Amselem; David S. Williams; Brian J. Mitchell; Iain A. Drummond; Edgar A. Otto; Heymut Omran; Michael R. Knowles; Friedhelm Hildebrandt;Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent respiratory infections and male infertility. Using whole-exome resequencing and high-throughput mutation analysis, we identified recessive biallelic mutations in ZMYND10 in 14 families and mutations in the recently identified LRRC6 in 13 families. We show that ZMYND10 and LRRC6 interact and that certain ZMYND10 and LRRC6 mutations abrogate the interaction between the LRRC6 CS domain and the ZMYND10 C-terminal domain. Additionally, ZMYND10 and LRRC6 colocalize with the centriole markers SAS6 and PCM1. Mutations in ZMYND10 result in the absence of the axonemal protein components DNAH5 and DNALI1 from respiratory cilia. Animal models support the association between ZMYND10 and human PCD, given that zmynd10 knockdown in zebrafish caused ciliary paralysis leading to cystic kidneys and otolith defects and that knockdown in Xenopus interfered with ciliogenesis. Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function. International audience
The American Journal... arrow_drop_down The American Journal of Human GeneticsArticleLicense: Elsevier Non-CommercialData sources: UnpayWallUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2013Data sources: Universitätsbibliographie, Universität Duisburg-EssenThe American Journal of Human GeneticsOther literature type . Article . 2013License: Elsevier Non-CommercialCroatian Scientific Bibliography - CROSBIArticle . 2013Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu185 citations 185 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert The American Journal... arrow_drop_down The American Journal of Human GeneticsArticleLicense: Elsevier Non-CommercialData sources: UnpayWallUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2013Data sources: Universitätsbibliographie, Universität Duisburg-EssenThe American Journal of Human GeneticsOther literature type . Article . 2013License: Elsevier Non-CommercialCroatian Scientific Bibliography - CROSBIArticle . 2013Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 France, France, United Kingdom, Spain, United Kingdom, Netherlands, United Kingdom, ItalySpringer Science and Business Media LLC WTWTJeroen R. Huyghe; Stephanie A. Bien; Tabitha A. Harrison; Hyun Min Kang; Sai Chen; Stephanie L. Schmit; David V. Conti; Jihyoun Jeon; Christopher K. Edlund; Peyton Greenside; Fredrick R. Schumacher; Joshua D. Smith; David M. Levine; Sarah C. Nelson; Nasa Sinnott-Armstrong; Demetrius Albanes; M. Henar Alonso; Kristin E. Anderson; Coral Arnau-Collell; Volker Arndt; Christina Bamia; Barbara L. Banbury; John A. Baron; Sonja I. Berndt; Stéphane Bézieau; D. Timothy Bishop; Juergen Boehm; Heiner Boeing; Hermann Brenner; Stefanie Brezina; Stephan Buch; Daniel D. Buchanan; Andrea N. Burnett-Hartman; Bette J. Caan; Peter T. Campbell; Christopher S. Carlson; Sergi Castellví-Bel; Andrew T. Chan; Jenny Chang-Claude; Stephen J. Chanock; Maria Dolores Chirlaque; Sang-Hee Cho; Charles M. Connolly; Amanda J. Cross; Keith R. Curtis; Albert de la Chapelle; Kimberly F. Doheny; David Duggan; Douglas F. Easton; Sjoerd G. Elias; Faye Elliott; Dallas R. English; Edith J. M. Feskens; Rocky Fischer; Liesel M. FitzGerald; David Forman; Manish Gala; Steven Gallinger; W. James Gauderman; Graham G. Giles; Jian Gong; Phyllis J. Goodman; William M. Grady; John S. Grove; Andrea Gsur; Marc J. Gunter; Jochen Hampe; Heather Hampel; Sophia Harlid; Richard B. Hayes; Philipp Hofer; Michael Hoffmeister; Wen Yi Huang; Thomas J. Hudson; David J. Hunter; Gemma Ibáñez-Sanz; Gregory Idos; Roxann G. Ingersoll; Rebecca D. Jackson; Eric J. Jacobs; Mark A. Jenkins; Amit Joshi; Temitope O. Keku; Timothy J. Key; Hyeong Rok Kim; Emiko Kobayashi; Laurence N. Kolonel; Charles Kooperberg; Tilman Kühn; Sébastien Küry; Susanna C. Larsson; Cecelia A. Laurie; Suzanne M. Leal; Soo-Chin Lee; Flavio Lejbkowicz; Mathieu Lemire; Christopher I. Li; Li Li; Wolfgang Lieb; Yi Lin; Annika Lindblom; Noralane M. Lindor; Hua Ling; Tin Louie; Satu Männistö; Sanford D. Markowitz; Vicente Martín; Giovanna Masala; Caroline McNeil; Marilena Melas; Roger L. Milne; Lorena Moreno; Neil Murphy; Robin Myte; Alessio Naccarati; Polly A. Newcomb; Kenneth Offit; Shuji Ogino; N. Charlotte Onland-Moret; Barbara Pardini; Patrick S. Parfrey; Rachel Pearlman; Vittorio Perduca; Paul D.P. Pharoah; Mila Pinchev; Elizabeth A. Platz; Ross L. Prentice; Elizabeth W. Pugh; Leon Raskin; Gad Rennert; Hedy S. Rennert; Elio Riboli; Miguel Rodríguez-Barranco; Jane Romm; Lori C. Sakoda; Clemens Schafmayer; Robert E. Schoen; Daniela Seminara; Mitul Shah; Min-Ho Shin; Katerina Shulman; Sabina Sieri; Martha L. Slattery; Melissa C. Southey; Zsofia K. Stadler; Yu Ru Su; Catherine M. Tangen; Stephen N. Thibodeau; Duncan C. Thomas; Amanda E. Toland; Antonia Trichopoulou; Cornelia M. Ulrich; David Van Den Berg; Fränzel J.B. Van Duijnhoven; Bethany Van Guelpen; Joseph Vijai; Pavel Vodicka; Ludmila Vodickova; Veronika Vymetalkova; Korbinian Weigl; Stephanie J. Weinstein; Emily White; Aung Ko Win; C. Roland Wolf; Alicja Wolk; Michael O. Woods; Anna H. Wu; Syed H.E. Zaidi; Wei Zheng; Peter C. Scacheri; John D. Potter; Michael C. Bassik; Anshul Kundaje; Graham Casey; Victor Moreno; Gonçalo R. Abecasis; Deborah A. Nickerson; Stephen B. Gruber; Li Hsu; Ulrike Peters;To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P<5×10−8, bringing the number of known independent signals for CRC to approximately 100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs, somatic drivers, and support a role of immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of underlying biology, and impact personalized screening strategies and drug development. Reporting Summary. Further information on experimental design is available in the Life Sciences Reporting Summary linked to this article.
Europe PubMed Centra... arrow_drop_down Nature Genetics; Archivio Istituzionale (AperTO); Research@WUR; Oxford University Research ArchiveArticle . 2018 . 2019License: Springer TDMNature Genetics; Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2018License: implied-oaSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu358 citations 358 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 285visibility views 285 download downloads 401 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Nature Genetics; Archivio Istituzionale (AperTO); Research@WUR; Oxford University Research ArchiveArticle . 2018 . 2019License: Springer TDMNature Genetics; Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2018License: implied-oaSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2011 France, France, France, CanadaThe Optical Society WTWTDehaes, Mathieu; Gagnon, Louis; Lesage, Frédéric; Pélégrini-Issac, Mélanie; Vignaud, Alexandre; Valabrègue, Romain; Grebe, Reinhard; Wallois, Fabrice; Benali, Habib;Diffuse optical imaging (DOI) is a non invasive technique allowing the recovery of hemodynamic changes in the brain. Due to the diffusive nature of photon propagation in turbid media and the fact that cerebral tissues are located around 1.5 cm under the adult human scalp, DOI measurements are subject to partial volume errors. DOI measurements are also sensitive to large pial vessels because oxygenated and deoxygenated hemoglobin are the dominant chromophores in the near infrared window. In this study, the effect of the extra-cerebral vasculature in proximity of the sagittal sinus was investigated for its impact on DOI measurements simulated over the human adult visual cortex. Numerical Monte Carlo simulations were performed on two specific models of the human head derived from magnetic resonance imaging (MRI) scans. The first model included the extra-cerebral vasculature in which constant hemoglobin concentrations were assumed while the second did not. The screening effect of the vasculature was quantified by comparing recovered hemoglobin changes from each model for different optical arrays and regions of activation. A correction factor accounting for the difference between the recovered and the simulated hemoglobin changes was computed in each case. The results show that changes in hemoglobin concentration are better estimated when the extra-cerebral vasculature is modeled and the correction factors obtained in this case were at least 1.4-fold lower. The effect of the vasculature was also examined in a high-density diffuse optical tomography configuration. In this case, the difference between changes in hemoglobin concentration recovered with each model was reduced down to 10%. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu26 citations 26 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 France, France, Switzerland, United Kingdom, Denmark, ItalySpringer Science and Business Media LLC WT, UKRI | RootDetect: Remote Detect..., NIH | Isotope-Assisted Differen... +1 projectsWT ,UKRI| RootDetect: Remote Detection and Precision Management of Root Health ,NIH| Isotope-Assisted Differential Metabolomics (RMI) ,NIH| Networks and Pathways of Lysine ModificationSuresh Mathivanan; Mukhtar Ahmed; Natalie G. Ahn; Hainard Alexandre; Ramars Amanchy; Philip C. Andrews; Joel S. Bader; Brian M. Balgley; Marcus Bantscheff; Keiryn L. Bennett; Erik Björling; Blagoy Blagoev; Ron Bose; Samir K. Brahmachari; Alma S Burlingame; Xosé R. Bustelo; Gerard Cagney; Greg T. Cantin; Helene L. Cardasis; Julio E. Celis; Raghothama Chaerkady; Feixia Chu; Philip A. Cole; Catherine E. Costello; Robert J. Cotter; David K. Crockett; James P. DeLany; Angelo M. De Marzo; Leroi V. DeSouza; Eric W. Deutsch; E. Dransfield; Gerard Drewes; Arnaud Droit; Michael J. Dunn; Kojo S.J. Elenitoba-Johnson; Rob M. Ewing; Jennifer E. Van Eyk; Vitor M. Faça; Jayson A. Falkner; Xiangming Fang; Catherine Fenselau; Daniel Figeys; Pierre Gagné; Cecilia Gelfi; Kris Gevaert; Jeffrey M. Gimble; Florian Gnad; Renu Goel; Pavel Gromov; Samir M. Hanash; William S. Hancock; H. C. Harsha; Gerald W. Hart; Faith A. Hays; Fuchu He; Prashantha Hebbar; Kenny Helsens; Heiko Hermeking; Winston Hide; Karin Hjernø; Denis F. Hochstrasser; Oliver Hofmann; David M Horn; Ralph H. Hruban; Nieves Ibarrola; Peter James; Ole N. Jensen; Pia Hønnerup Jensen; Peter Jung; Kumaran Kandasamy; Indu Kheterpal; Reiko F. Kikuno; Ulrike Korf; Roman Körner; Bernhard Kuster; Min-Seok Kwon; Hyoung Joo Lee; Young Jin Lee; Michael Lefevre; Minna Lehvaslaiho; Pierre Lescuyer; Fredrik Levander; Megan S. Lim; Christian Löbke; Joseph A. Loo; Matthias Mann; Lennart Martens; Juan Martínez-Heredia; Mark E. McComb; James P. McRedmond; Alexander Mehrle; Rajasree Menon; Christine A. Miller; Harald Mischak; Subburaman Mohan; Riaz Mohmood; Henrik Molina; Michael Moran; James D. Morgan; Robert Moritz; Martine Morzel; David C. Muddiman; Anuradha Nalli; J. Daniel Navarro; Thomas A. Neubert; Osamu Ohara; Rafael Oliva; Gilbert S. Omenn; Masaaki Oyama; Young Ki Paik; Kyla Pennington; Rainer Pepperkok; Balamurugan Periaswamy; Emanuel F. Petricoin; Guy G. Poirier; T. S. Keshava Prasad; Samuel O. Purvine; B. Abdul Rahiman; Prasanna Ramachandran; Y. L. Ramachandra; Robert H. Rice; Jens Rick; Ragna Rönnholm; Johanna Salonen; Jean-Charles Sanchez; Thierry Sayd; Beerelli Seshi; Kripa Shankari; Shi Jun Sheng; Vivekananda Shetty; K. Shivakumar; Richard J. Simpson; Ravi Sirdeshmukh; K. W. Michael Siu; Jeffrey C. Smith; Richard D. Smith; David J. States; Sumio Sugano; Matthew J. Sullivan; Giulio Superti-Furga; Maarit Takatalo; Visith Thongboonkerd; Jonathan C. Trinidad; Mathias Uhlén; Joël Vandekerckhove; Julian Vasilescu; Timothy D. Veenstra; Jose-Manuel Vidal-Taboada; Mauno Vihinen; Robin Wait; Xiaoyue Wang; Stefan Wiemann; Billy Wu; Tao Xu; John R. Yates; Jun Zhong; Ming Zhou; Yunping Zhu; Petra Zürbig; Akhilesh Pandey;Proteomic technologies, such as yeast two-hybrid, mass spectrometry (MS), protein/peptide arrays and fluorescence microscopy, yield multi-dimensional data sets, which are often quite large and either not published or published as supplementary information that is not easily searchable. Without a system in place for standardizing and sharing data, it is not fruitful for the biomedical community to contribute these types of data to centralized repositories.
Archivio Istituziona... arrow_drop_down Oxford University Research Archive; Nature BiotechnologyArticle . 2008 . 2016License: Springer TDMUniversity of Southern Denmark Research OutputArticle . 2008Data sources: University of Southern Denmark Research OutputHAL - Université de Lille; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2008License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu149 citations 149 popularity Top 10% influence Top 1% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Oxford University Research Archive; Nature BiotechnologyArticle . 2008 . 2016License: Springer TDMUniversity of Southern Denmark Research OutputArticle . 2008Data sources: University of Southern Denmark Research OutputHAL - Université de Lille; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2008License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 FranceMDPI AG ANR | DYNAMO, WTANR| DYNAMO ,WTDelan-Forino, Clémentine; Deforges, Jules; Benard, Lionel; Sargueil, Bruno; Maurel, Marie-Christine; Torchet, Claire;Viroids are small pathogenic circular single-stranded RNAs, present in two complementary sequences, named plus and minus, in infected plant cells. A high degree of complementarities between different regions of the RNAs allows them to adopt complex structures. Since viroids are naked non-coding RNAs, interactions with host factors appear to be closely related to their structural and catalytic characteristics. Avocado sunblotch viroid (ASBVd), a member of the family Avsunviroidae, replicates via a symmetric OPEN ACCESS Viruses 2014, 6 490 RNA-dependant rolling-circle process, involving self-cleavage via hammerhead ribozymes. Consequently, it is assumed that ASBVd plus and minus strands adopt similar structures. Moreover, by computer analyses, a quasi-rod-like secondary structure has been predicted. Nevertheless, secondary and tertiary structures of both polarities of ASBVd remain unsolved. In this study, we analyzed the characteristic of each strand of ASBVd through biophysical analyses. We report that ASBVd transcripts of plus and minus polarities exhibit differences in electrophoretic mobility under native conditions and in thermal denaturation profiles. Subsequently, the secondary structures of plus and minus polarities of ASBVd were probed using the RNA-selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) method. The models obtained show that both polarities fold into different structures. Moreover, our results suggest the existence of a kissing-loop interaction within the minus strand that may play a role in in vivo viroid life cycle. International audience
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/v6020489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/v6020489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, Germany, Spain, Sweden, Finland, United Kingdom, Iceland, United Kingdom, Denmark, Spain, Belgium, United Kingdom, China (People's Republic of), Norway, United Kingdom, Belgium, United Kingdom, Spain, Spain, Netherlands, SwedenSpringer Science and Business Media LLC NWO | Secure and gentle grip of..., NIH | A genome-wide association..., EC | COGS +5 projectsNWO| Secure and gentle grip of delicate biological tissues ,NIH| A genome-wide association study for breast cancer in BRCA1 mutation carriers ,EC| COGS ,CIHR ,WT ,NIH| Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) ,NIH| Elucidating Loci Involved in Prostate Cancer Suceptibility ,NIH| Discovery Expansion and ReplicationFergus J. Couch; Kyriaki Michailidou; Gustavo Mendoza-Fandiño; Silje Nord; Janna Lilyquist; Curtis Olswold; Habibul Ahsan; Kristiina Aittomäki; Christine B. Ambrosone; Irene L. Andrulis; Hoda Anton-Culver; Brita Arver; Monica Barile; Rosa B. Barkardottir; Daniel Barrowdale; Lars Beckmann; Matthias W. Beckmann; Javier Benitez; Stephanie V. Blank; Carl Blomqvist; Natalia Bogdanova; Stig E. Bojesen; Bernardo Bonanni; Hiltrud Brauch; Hermann Brenner; Barbara Burwinkel; Saundra S. Buys; Trinidad Caldés; Maria A. Caligo; Federico Canzian; Jane Carpenter; Stephen J. Chanock; Wendy K. Chung; Kathleen Claes; Angela Cox; Simon S. Cross; Julie M. Cunningham; Kamila Czene; Mary B. Daly; Francesca Damiola; Hatef Darabi; Miguel de la Hoya; Peter Devilee; Orland Diez; Yuan C. Ding; Riccardo Dolcetti; Cecilia M. Dorfling; Isabel dos-Santos-Silva; Martine Dumont; Alison M. Dunning; Diana Eccles; Hans Ehrencrona; Arif B. Ekici; Heather Eliassen; Jonine Figueroa; Florentia Fostira; W. D. Foulkes; Tara M. Friebel; Eitan Friedman; Debra Frost; Marike Gabrielson; Marilie D. Gammon; Patricia A. Ganz; Judy Garber; Mia M. Gaudet; SA Gayther; Anne-Marie Gerdes; Maya Ghoussaini; Graham G. Giles; Mark S. Goldberg; David E. Goldgar; Anna González-Neira; Mark H. Greene; Pascal Guénel; Marc J. Gunter; Lothar Haeberle; Christopher A. Haiman; Thomas Hansen; Steven N. Hart; Sue Healey; Tuomas Heikkinen; Brian E. Henderson; Frans B. L. Hogervorst; Antoinette Hollestelle; M.J. Hooning; Robert N. Hoover; John L. Hopper; David J. Hunter; Tomasz Huzarski; Evgeny N. Imyanitov; Claudine Isaacs; Paul A. James; Ramunas Janavicius; Uffe Birk Jensen; Esther M. John; Michael Jones; Maria Kabisch; Siddhartha Kar; Beth Y. Karlan; Sofia Khan; Muhammad G. Kibriya; Julia A. Knight; Yon Ko; Irene Konstantopoulou; Veli-Matti Kosma; Vessela N. Kristensen; Ava Kwong; Yael Laitman; Diether Lambrechts; Conxi Lázaro; Eunjung Lee; Jenny Lester; Annika Lindblom; S. Lindstrom; Jianjun Liu; Jirong Long; Jan Lubinski; Phuong L. Mai; Enes Makalic; Kathleen E. Malone; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Lesley McGuffog; Alfons Meindl; Austin Miller; Roger L. Milne; Penelope Miron; Marco Montagna; Sylvie Mazoyer; Anna Marie Mulligan; Taru A. Muranen; Katherine L. Nathanson; Susan L. Neuhausen; Heli Nevanlinna; Børge G. Nordestgaard; Robert L. Nussbaum; Kenneth Offit; Olufunmilayo I. Olopade; Janet E. Olson; Ana Osorio; Sue K. Park; Petra H.M. Peeters; Bernard Peissel; Paolo Peterlongo; Julian Peto; Bruce Poppe; Katri Pylkäs; Paolo Radice; Nazneen Rahman; Christine Rappaport; Gad Rennert; Andrea L. Richardson; Mark E. Robson; Isabelle Romieu; Anja Rudolph; María José Sánchez; Regina M. Santella; Elinor J. Sawyer; Daniel F. Schmidt; Marjanka K. Schmidt; Rita K. Schmutzler; Fredrick R. Schumacher; Rodney J. Scott; Leigha Senter; Priyanka Sharma; Jacques Simard; Christian F. Singer; Olga M. Sinilnikova; Melissa C. Southey; Doris Steinemann; Marie Stenmark-Askmalm; Dominique Stoppa-Lyonnet; Anthony J. Swerdlow; Csilla I. Szabo; Rulla M. Tamimi; William J. Tapper; Manuel R. Teixeira; Soo-Hwang Teo; Mary Beth Terry; Mads Thomassen; D Thompson; Laima Tihomirova; Amanda E. Toland; Robert A.E.M. Tollenaar; Ian Tomlinson; Thérèse Truong; Helen Tsimiklis; Alex Teulé; Rosario Tumino; Nadine Tung; Clare Turnbull; Giski Ursin; Elizabeth J. van Rensburg; Raymonda Varon-Mateeva; Zhaoming Wang; Elisabete Weiderpass; Jeffrey N. Weitzel; Alice S. Whittemore; Hans Wildiers; Robert Winqvist; Xiaohong R. Yang; Drakoulis Yannoukakos; Song Yao; M. Pilar Zamora; Per Hall; Peter Kraft; Susan L. Slager; Georgia Chenevix-Trench; Alvaro A.N. Monteiro; Montserrat Garcia-Closas; Douglas F. Easton;handle: 1765/81552 , 1854/LU-7900406 , 10037/10393 , 1887/113206 , 20.500.11820/11e3b572-7147-4e25-85b6-d9cc7351cc4a , 10668/10025 , 2445/126861 , 2336/611194 , 10481/44831 , 10722/226424 , 20.500.12105/7867 , 20.500.12530/26734 , 1874/344341 , 10138/163123
pmid: 27117709
pmc: PMC4853421
handle: 1765/81552 , 1854/LU-7900406 , 10037/10393 , 1887/113206 , 20.500.11820/11e3b572-7147-4e25-85b6-d9cc7351cc4a , 10668/10025 , 2445/126861 , 2336/611194 , 10481/44831 , 10722/226424 , 20.500.12105/7867 , 20.500.12530/26734 , 1874/344341 , 10138/163123
pmid: 27117709
pmc: PMC4853421
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction. ispartof: Nature Communications vol:7 pages:11375- ispartof: location:England status: published
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2018 . 2016License: CC BYRefubium - Repositorium der Freien Universität BerlinArticle . 2016License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryUniversity of Southern Denmark Research OutputArticle . 2016Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTALirias; Oxford University Research Archive; NARCIS; PURE Aarhus University; Ghent University Academic Bibliography; Nature CommunicationsArticle . 2016 . 2018License: CC BYGhent University Academic BibliographyArticle . 2016Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2016Data sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2016License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2017 . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms11375&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu93 citations 93 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 162visibility views 162 download downloads 161 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2018 . 2016License: CC BYRefubium - Repositorium der Freien Universität BerlinArticle . 2016License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryUniversity of Southern Denmark Research OutputArticle . 2016Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTALirias; Oxford University Research Archive; NARCIS; PURE Aarhus University; Ghent University Academic Bibliography; Nature CommunicationsArticle . 2016 . 2018License: CC BYGhent University Academic BibliographyArticle . 2016Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2016Data sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2016License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2017 . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms11375&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 France, Netherlands, Australia, France, ItalyFrontiers Media SA NWO | Diffusion MRI analysis be..., NIH | Axon, Testosterone and Me..., WTNWO| Diffusion MRI analysis beyond connectography ,NIH| Axon, Testosterone and Mental Health during Adolescence ,WTAuthors: Szabolcs David; Anneriet M. Heemskerk; Francesco Corrivetti; Michel Thiebaut de Schotten; +12 AuthorsSzabolcs David; Anneriet M. Heemskerk; Francesco Corrivetti; Michel Thiebaut de Schotten; Silvio Sarubbo; Francesco Corsini; Alessandro De Benedictis; Laurent Petit; Max A. Viergever; Derek K. Jones; Emmanuel Mandonnet; Hubertus Axer; John Evans; Tomáš Paus; Tomáš Paus; Alexander Leemans;International audience; Fiber tractography (FT) using diffusion magnetic resonance imaging (dMRI) is widely used for investigating microstructural properties of white matter (WM) fiber-bundles and for mapping structural connections of the human brain. While studying the architectural configuration of the brain's circuitry with FT is not without controversy, recent progress in acquisition, processing, modeling, analysis, and visualization of dMRI data pushes forward the reliability in reconstructing WM pathways. Despite being aware of the well-known pitfalls in analyzing dMRI data and several other limitations of FT discussed in recent literature, we present the superoanterior fasciculus (SAF), a novel bilateral fiber tract in the frontal region of the human brain that-to the best of our knowledge-has not been documented. The SAF has a similar shape to the anterior part of the cingulum bundle, but it is located more frontally. To minimize the possibility that these FT findings are based on acquisition or processing artifacts, different dMRI data sets and processing pipelines have been used to describe the SAF. Furthermore, we evaluated the configuration of the SAF with complementary methods, such as polarized light imaging (PLI) and human brain dissections. The FT results of the SAF demonstrate a long pathway, consistent across individuals, while the human dissections indicate fiber pathways connecting the postero-dorsal with the antero-dorsal cortices of the frontal lobe.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnana.2019.00024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 5 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnana.2019.00024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Netherlands, Denmark, United Kingdom, FranceAmerican Diabetes Association WTWTDanne, Thomas; Nimri, Revital; Battelino, Tadej; Bergenstal, Richard M.; Close, Kelly L.; DeVries, J. Hans; Garg, Satish; Heinemann, Lutz; Hirsch, Irl; Amiel, Stephanie A.; Beck, Roy; Bosi, Emanuele; Buckingham, Bruce; Cobelli, Claudio; Dassau, Eyal; Doyle, Francis J.; Heller, Simon; Hovorka, Roman; Jia, Weiping; Jones, Tim; Kordonouri, Olga; Kovatchev, Boris; Kowalski, Aaron; Laffel, Lori; Maahs, David; Murphy, Helen R.; Nørgaard, Kirsten; Parkin, Christopher G.; Renard, Eric; Saboo, Banshi; Scharf, Mauro; Tamborlane, William V.; Weinzimer, Stuart A.; Phillip, Moshe;Measurement of glycated hemoglobin (HbA1c) has been the traditional method for assessing glycemic control. However, it does not reflect intra- and interday glycemic excursions that may lead to acute events (such as hypoglycemia) or postprandial hyperglycemia, which have been linked to both microvascular and macrovascular complications. Continuous glucose monitoring (CGM), either from real-time use (rtCGM) or intermittently viewed (iCGM), addresses many of the limitations inherent in HbA1c testing and self-monitoring of blood glucose. Although both provide themeans to move beyond the HbA1c measurement as the sole marker of glycemic control, standardized metrics for analyzing CGM data are lacking. Moreover, clear criteria for matching people with diabetes to themost appropriate glucose monitoring methodologies, as well as standardized advice about howbest to use the new information they provide, have yet to be established. In February 2017, the Advanced Technologies & Treatments for Diabetes (ATTD) Congress convened an international panel of physicians, researchers, and individuals with diabetes who are expert in CGM technologies to address these issues. This article summarizes the ATTD consensus recommendations and represents the current understanding of how CGM results can affect outcomes.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1K citations 1,363 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 25visibility views 25 download downloads 161 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2013 Italy, Ireland, United Kingdom, Netherlands, United KingdomSpringer Science and Business Media LLC WT, EC | COGS, NIH | Characterizing Genetic Su... +6 projectsWT ,EC| COGS ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer: The BPC3. ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer;the BPC3 ,NIH| Genetic epidemiology of cell division regulation in breast cancer ,NIH| Breast &Prostate Cancer &Hormone-related Gene Variants ,NIH| Breast &prostate cancer &hormone-related gene variants ,NIH| Discovery Expansion and Replication ,CIHRAuthors: Montserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; +212 AuthorsMontserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Nick Orr; Suhn K. Rhie; Elio Riboli; Heather Spencer Feigelson; Diana Eccles; Hiltrud Brauch; Jane Carpenter; Heli Nevanlinna; Graham G. Giles; Angela Cox; John L. Hopper; Manjeet K. Bolla; Qin Wang; Joe Dennis; William J. Howat; Nils Schoof; Stig E. Bojesen; Diether Lambrechts; Irene L. Andrulis; Pascal Guénel; Antoinette Hollestelle; Olivia Fletcher; Robert Winqvist; Hermann Brenner; Alfons Meindl; Annika Lindblom; Peter Devillee; Mark S. Goldberg; Jan Lubinski; Vessela N. Kristensen; Anthony J. Swerdlow; Thilo Dörk; Keitaro Matsuo; Anna H. Wu; Paolo Radice; Soo Hwang Teo; William Blot; Daehee Kang; Mikael Hartman; Suleeporn Sangrajrang; Chen-Yang Shen; Melissa C. Southey; Fleur Hammet; Jennifer Stone; Emiel J. Th. Rutgers; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Michael G. Schrauder; Arif B. Ekici; Matthias W. Beckmann; Isabel dos Santos Silva; Nichola Johnson; Ian Tomlinson; Michael J. Kerin; Federick Marme; Andreas Schneeweiss; Thérèse Truong; Pierre Laurent-Puig; Pierre Kerbrat; Børge G. Nordestgaard; Sune F. Nielsen; Henrik Flyger; Roger L. Milne; Jose Ignacio Arias Perez; Primitiva Menéndez; Heiko Müller; Volker Arndt; Taru A. Muranen; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Tuomas Heikkinen; Hidemi Ito; Hiroji Iwata; Yasushi Yatabe; Natalia Antonenkova; Sara Margolin; Vesa Kataja; Veli-Matti Kosma; Jaana M. Hartikainen; Rosemary L. Balleine; Chiu-Chen Tseng; Patrick Neven; Anne Sophie Dieudonne; Anja Rudolph; Stefan Nickels; Dieter Flesch-Janys; Paolo Peterlongo; Bernard Peissel; Loris Bernard; Janet E. Olson; Xianshu Wang; Gianluca Severi; Laura Baglietto; Catriona McLean; Gerhard A. Coetzee; Ye Feng; Brian E. Henderson; Fredrick R. Schumacher; Natalia Bogdanova; Cheng Har Yip; Nur Aishah Taib; Martha J. Shrubsole; Jirong Long; Katri Pylkäs; Julia A. Knight; Gord Glendon; Anna Marie Mulligan; R.A.E.M. Tollenaar; Caroline M. Seynaeve; Mieke Kriege; Maartje J. Hooning; Ans M.W. van den Ouweland; Yu Tang Gao; Hui Cai; Sabapathy P. Balasubramanian; Simon S. Cross; Malcolm W.R. Reed; Lisa B. Signorello; Qiuyin Cai; Mitul Shah; Ching Wan Chan; Kee Seng Chia; Anna Jakubowska; Katarzyna Jaworska; Katarzyna Durda; Pei Ei Wu; Jyh Cherng Yu; Michael Jones; Daniel C. Tessier; Anna González-Neira; Guillermo Pita; M. Rosario Alonso; Daniel Vincent; Francois Bacot; Elisa V. Bandera; Esther M. John; Gary K. Chen; Jennifer J. Hu; Jorge L. Rodriguez-Gil; Leslie Bernstein; Michael F. Press; Regina G. Ziegler; Robert M. Millikan; Sandra Deming-Halverson; Sue A. Ingles; Quinten Waisfisz; Helen Tsimiklis; Enes Makalic; Daniel F. Schmidt; Minh Bui; Lorna Gibson; Bertram Müller-Myhsok; Rita K. Schmutzler; Rebecca Hein; Norbert Dahmen; Lars Beckmann; Kamila Czene; Astrid Irwanto; Clare Turnbull; Nazneen Rahman; André G. Uitterlinden; Fernando Rivadeneira; Curtis Olswold; Susan L. Slager; Robert Pilarski; Foluso O. Ademuyiwa; Irene Konstantopoulou; Nicholas G. Martin; Grant W. Montgomery; Dennis J. Slamon; Claudia Rauh; Michael P. Lux; Sebastian M. Jud; Priyanka Sharma; William J. Tapper; Sue Gerty; Dimitrios Trichopoulos; Rosario Tumino; Petra H.M. Peeters; Rudolf Kaaks; Daniele Campa; Federico Canzian; Elisabete Weiderpass; Mattias Johansson; Kay-Tee Khaw; Ruth C. Travis; Françoise Clavel-Chapelon; Laurence N. Kolonel; Constance Chen; Andrew H. Beck; Susan E. Hankinson; Robert N. Hoover; Jolanta Lissowska; Jonine D. Figueroa; Daniel I. Chasman; Mia M. Gaudet; W. Ryan Diver; Walter C. Willett; Jacques Simard; Javier Benitez; Alison M. Dunning; Mark E. Sherman; Georgia Chenevix-Trench; Stephen J. Chanock; Per Hall; Paul D.P. Pharoah; Douglas F. Easton; Christopher A. Haiman; Peter Kraft;Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
Nature Genetics; Oxf... arrow_drop_down Nature Genetics; Oxford University Research Archive; Archivio della Ricerca - Università di Pisa; The University of Manchester - Institutional Repository; NARCISOther literature type . Article . 2013 . 2016License: Springer TDMData sources: European Union Open Data Portal; Oxford University Research Archive; Erasmus University Rotterdam - Research Information Portal; Archivio della Ricerca - Università di Pisa; Crossref; SESAM Publication Database - FP7 HEALTH; The University of Manchester - Institutional Repository; NARCISArchivio della Ricerca - Università di PisaArticle . 2013Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu394 citations 394 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 17visibility views 17 download downloads 132 Powered bymore_vert Nature Genetics; Oxf... arrow_drop_down Nature Genetics; Oxford University Research Archive; Archivio della Ricerca - Università di Pisa; The University of Manchester - Institutional Repository; NARCISOther literature type . Article . 2013 . 2016License: Springer TDMData sources: European Union Open Data Portal; Oxford University Research Archive; Erasmus University Rotterdam - Research Information Portal; Archivio della Ricerca - Università di Pisa; Crossref; SESAM Publication Database - FP7 HEALTH; The University of Manchester - Institutional Repository; NARCISArchivio della Ricerca - Università di PisaArticle . 2013Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2009 Denmark, Italy, Netherlands, United KingdomElsevier BV WTWTBarry A. Chioza; Jean Aicardi; Harald N. Aschauer; Oebele F. Brouwer; Petra M.C. Callenbach; Athanasios Covanis; Joseph M. Dooley; Olivier Dulac; Martina Durner; Orvar Eeg-Olofsson; Martha Feucht; M. L. Friis; Renzo Guerrini; Marianne J. Kjeldsen; Rima Nabbout; Lina Nashef; Thomas Sander; Auli Siren; Elaine C. Wirrell; Paul M. McKeigue; Robert Robinson; R. Mark Gardiner; Kate V. Everett;pmid: 19837565
pmc: PMC2791882
Childhood absence epilepsy (CAE) is an idiopathic generalised epilepsy (IGE) characterised by typical absence seizures manifested by transitory loss of awareness with 2.5-4 Hz spike-wave complexes on ictal EEG. A genetic component to the aetiology is well recognised but the mechanism of inheritance and the genes involved are yet to be fully established. A genome wide single nucleotide polymorphism (SNP)-based high density linkage scan was carried out using 41 nuclear pedigrees with at least two affected members. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1 and a susceptibility locus was identified on chromosome 3p23-p14 (Z(mean)=3.9, p<0.0001; HLOD=3.3, alpha=0.7). The linked region harbours the functional candidate genes TRAK1 and CACNA2D2. Fine-mapping using a tagSNP approach demonstrated disease association with variants in TRAK1. Udgivelsesdato: 2009-Dec
Europe PubMed Centra... arrow_drop_down University of Southern Denmark Research OutputArticle . 2009Data sources: University of Southern Denmark Research Outputadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 30 Powered bymore_vert Europe PubMed Centra... arrow_drop_down University of Southern Denmark Research OutputArticle . 2009Data sources: University of Southern Denmark Research Outputadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2013 France, CroatiaElsevier BV NIH | Novel genetics, pathobiol..., WT, NIH | Identifying all Meckel-li... +4 projectsNIH| Novel genetics, pathobiology and therapy of nephronophthisis-related ciliopathies ,WT ,NIH| Identifying all Meckel-like ciliopathy genes by established total exome capture a ,EC| SYSCILIA ,NIH| Pathogenesis of PCD Lung Disease ,NIH| Colorado Clinical and Translational Science Institute (UL1) ,NIH| Genetic Disorder of Mucocilary ClearanceAuthors: Maimoona A. Zariwala; Heon Yung Gee; Małgorzata Kurkowiak; Dalal A. Al-Mutairi; +54 AuthorsMaimoona A. Zariwala; Heon Yung Gee; Małgorzata Kurkowiak; Dalal A. Al-Mutairi; Margaret W. Leigh; Toby W. Hurd; Rim Hjeij; Sharon D. Dell; Moumita Chaki; Gerard W. Dougherty; Mohamed Adan; Philip C. Spear; Julian Esteve-Rudd; Niki T. Loges; Margaret Rosenfeld; Katrina A. Diaz; Heike Olbrich; Whitney E. Wolf; Eamonn Sheridan; Trevor F.C. Batten; Jan Halbritter; Jonathan D. Porath; Stefan Kohl; Svjetlana Lovric; Daw Yang Hwang; Jessica E. Pittman; Kimberlie A. Burns; Thomas W. Ferkol; Scott D. Sagel; Kenneth N. Olivier; Lucy Morgan; Claudius Werner; Johanna Raidt; Petra Pennekamp; Zhaoxia Sun; Weibin Zhou; Rannar Airik; Sivakumar Natarajan; Susan J. Allen; Israel Amirav; Dagmar Wieczorek; Kerstin Landwehr; Kim G. Nielsen; Nicolaus Schwerk; Jadranka Sertić; Gabriele Köhler; Joseph Washburn; Shawn Levy; Shuling Fan; Cordula Koerner-Rettberg; Serge Amselem; David S. Williams; Brian J. Mitchell; Iain A. Drummond; Edgar A. Otto; Heymut Omran; Michael R. Knowles; Friedhelm Hildebrandt;Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent respiratory infections and male infertility. Using whole-exome resequencing and high-throughput mutation analysis, we identified recessive biallelic mutations in ZMYND10 in 14 families and mutations in the recently identified LRRC6 in 13 families. We show that ZMYND10 and LRRC6 interact and that certain ZMYND10 and LRRC6 mutations abrogate the interaction between the LRRC6 CS domain and the ZMYND10 C-terminal domain. Additionally, ZMYND10 and LRRC6 colocalize with the centriole markers SAS6 and PCM1. Mutations in ZMYND10 result in the absence of the axonemal protein components DNAH5 and DNALI1 from respiratory cilia. Animal models support the association between ZMYND10 and human PCD, given that zmynd10 knockdown in zebrafish caused ciliary paralysis leading to cystic kidneys and otolith defects and that knockdown in Xenopus interfered with ciliogenesis. Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function. International audience
The American Journal... arrow_drop_down The American Journal of Human GeneticsArticleLicense: Elsevier Non-CommercialData sources: UnpayWallUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2013Data sources: Universitätsbibliographie, Universität Duisburg-EssenThe American Journal of Human GeneticsOther literature type . Article . 2013License: Elsevier Non-CommercialCroatian Scientific Bibliography - CROSBIArticle . 2013Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu185 citations 185 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert The American Journal... arrow_drop_down The American Journal of Human GeneticsArticleLicense: Elsevier Non-CommercialData sources: UnpayWallUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2013Data sources: Universitätsbibliographie, Universität Duisburg-EssenThe American Journal of Human GeneticsOther literature type . Article . 2013License: Elsevier Non-CommercialCroatian Scientific Bibliography - CROSBIArticle . 2013Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 France, France, United Kingdom, Spain, United Kingdom, Netherlands, United Kingdom, ItalySpringer Science and Business Media LLC WTWTJeroen R. Huyghe; Stephanie A. Bien; Tabitha A. Harrison; Hyun Min Kang; Sai Chen; Stephanie L. Schmit; David V. Conti; Jihyoun Jeon; Christopher K. Edlund; Peyton Greenside; Fredrick R. Schumacher; Joshua D. Smith; David M. Levine; Sarah C. Nelson; Nasa Sinnott-Armstrong; Demetrius Albanes; M. Henar Alonso; Kristin E. Anderson; Coral Arnau-Collell; Volker Arndt; Christina Bamia; Barbara L. Banbury; John A. Baron; Sonja I. Berndt; Stéphane Bézieau; D. Timothy Bishop; Juergen Boehm; Heiner Boeing; Hermann Brenner; Stefanie Brezina; Stephan Buch; Daniel D. Buchanan; Andrea N. Burnett-Hartman; Bette J. Caan; Peter T. Campbell; Christopher S. Carlson; Sergi Castellví-Bel; Andrew T. Chan; Jenny Chang-Claude; Stephen J. Chanock; Maria Dolores Chirlaque; Sang-Hee Cho; Charles M. Connolly; Amanda J. Cross; Keith R. Curtis; Albert de la Chapelle; Kimberly F. Doheny; David Duggan; Douglas F. Easton; Sjoerd G. Elias; Faye Elliott; Dallas R. English; Edith J. M. Feskens; Rocky Fischer; Liesel M. FitzGerald; David Forman; Manish Gala; Steven Gallinger; W. James Gauderman; Graham G. Giles; Jian Gong; Phyllis J. Goodman; William M. Grady; John S. Grove; Andrea Gsur; Marc J. Gunter; Jochen Hampe; Heather Hampel; Sophia Harlid; Richard B. Hayes; Philipp Hofer; Michael Hoffmeister; Wen Yi Huang; Thomas J. Hudson; David J. Hunter; Gemma Ibáñez-Sanz; Gregory Idos; Roxann G. Ingersoll; Rebecca D. Jackson; Eric J. Jacobs; Mark A. Jenkins; Amit Joshi; Temitope O. Keku; Timothy J. Key; Hyeong Rok Kim; Emiko Kobayashi; Laurence N. Kolonel; Charles Kooperberg; Tilman Kühn; Sébastien Küry; Susanna C. Larsson; Cecelia A. Laurie; Suzanne M. Leal; Soo-Chin Lee; Flavio Lejbkowicz; Mathieu Lemire; Christopher I. Li; Li Li; Wolfgang Lieb; Yi Lin; Annika Lindblom; Noralane M. Lindor; Hua Ling; Tin Louie; Satu Männistö; Sanford D. Markowitz; Vicente Martín; Giovanna Masala; Caroline McNeil; Marilena Melas; Roger L. Milne; Lorena Moreno; Neil Murphy; Robin Myte; Alessio Naccarati; Polly A. Newcomb; Kenneth Offit; Shuji Ogino; N. Charlotte Onland-Moret; Barbara Pardini; Patrick S. Parfrey; Rachel Pearlman; Vittorio Perduca; Paul D.P. Pharoah; Mila Pinchev; Elizabeth A. Platz; Ross L. Prentice; Elizabeth W. Pugh; Leon Raskin; Gad Rennert; Hedy S. Rennert; Elio Riboli; Miguel Rodríguez-Barranco; Jane Romm; Lori C. Sakoda; Clemens Schafmayer; Robert E. Schoen; Daniela Seminara; Mitul Shah; Min-Ho Shin; Katerina Shulman; Sabina Sieri; Martha L. Slattery; Melissa C. Southey; Zsofia K. Stadler; Yu Ru Su; Catherine M. Tangen; Stephen N. Thibodeau; Duncan C. Thomas; Amanda E. Toland; Antonia Trichopoulou; Cornelia M. Ulrich; David Van Den Berg; Fränzel J.B. Van Duijnhoven; Bethany Van Guelpen; Joseph Vijai; Pavel Vodicka; Ludmila Vodickova; Veronika Vymetalkova; Korbinian Weigl; Stephanie J. Weinstein; Emily White; Aung Ko Win; C. Roland Wolf; Alicja Wolk; Michael O. Woods; Anna H. Wu; Syed H.E. Zaidi; Wei Zheng; Peter C. Scacheri; John D. Potter; Michael C. Bassik; Anshul Kundaje; Graham Casey; Victor Moreno; Gonçalo R. Abecasis; Deborah A. Nickerson; Stephen B. Gruber; Li Hsu; Ulrike Peters;To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P<5×10−8, bringing the number of known independent signals for CRC to approximately 100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs, somatic drivers, and support a role of immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of underlying biology, and impact personalized screening strategies and drug development. Reporting Summary. Further information on experimental design is available in the Life Sciences Reporting Summary linked to this article.
Europe PubMed Centra... arrow_drop_down Nature Genetics; Archivio Istituzionale (AperTO); Research@WUR; Oxford University Research ArchiveArticle . 2018 . 2019License: Springer TDMNature Genetics; Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2018License: implied-oaSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu358 citations 358 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 285visibility views 285 download downloads 401 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Nature Genetics; Archivio Istituzionale (AperTO); Research@WUR; Oxford University Research ArchiveArticle . 2018 . 2019License: Springer TDMNature Genetics; Repositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2018License: implied-oaSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2011 France, France, France, CanadaThe Optical Society WTWTDehaes, Mathieu; Gagnon, Louis; Lesage, Frédéric; Pélégrini-Issac, Mélanie; Vignaud, Alexandre; Valabrègue, Romain; Grebe, Reinhard; Wallois, Fabrice; Benali, Habib;Diffuse optical imaging (DOI) is a non invasive technique allowing the recovery of hemodynamic changes in the brain. Due to the diffusive nature of photon propagation in turbid media and the fact that cerebral tissues are located around 1.5 cm under the adult human scalp, DOI measurements are subject to partial volume errors. DOI measurements are also sensitive to large pial vessels because oxygenated and deoxygenated hemoglobin are the dominant chromophores in the near infrared window. In this study, the effect of the extra-cerebral vasculature in proximity of the sagittal sinus was investigated for its impact on DOI measurements simulated over the human adult visual cortex. Numerical Monte Carlo simulations were performed on two specific models of the human head derived from magnetic resonance imaging (MRI) scans. The first model included the extra-cerebral vasculature in which constant hemoglobin concentrations were assumed while the second did not. The screening effect of the vasculature was quantified by comparing recovered hemoglobin changes from each model for different optical arrays and regions of activation. A correction factor accounting for the difference between the recovered and the simulated hemoglobin changes was computed in each case. The results show that changes in hemoglobin concentration are better estimated when the extra-cerebral vasculature is modeled and the correction factors obtained in this case were at least 1.4-fold lower. The effect of the vasculature was also examined in a high-density diffuse optical tomography configuration. In this case, the difference between changes in hemoglobin concentration recovered with each model was reduced down to 10%. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu26 citations 26 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 France, France, Switzerland, United Kingdom, Denmark, ItalySpringer Science and Business Media LLC WT, UKRI | RootDetect: Remote Detect..., NIH | Isotope-Assisted Differen... +1 projectsWT ,UKRI| RootDetect: Remote Detection and Precision Management of Root Health ,NIH| Isotope-Assisted Differential Metabolomics (RMI) ,NIH| Networks and Pathways of Lysine ModificationSuresh Mathivanan; Mukhtar Ahmed; Natalie G. Ahn; Hainard Alexandre; Ramars Amanchy; Philip C. Andrews; Joel S. Bader; Brian M. Balgley; Marcus Bantscheff; Keiryn L. Bennett; Erik Björling; Blagoy Blagoev; Ron Bose; Samir K. Brahmachari; Alma S Burlingame; Xosé R. Bustelo; Gerard Cagney; Greg T. Cantin; Helene L. Cardasis; Julio E. Celis; Raghothama Chaerkady; Feixia Chu; Philip A. Cole; Catherine E. Costello; Robert J. Cotter; David K. Crockett; James P. DeLany; Angelo M. De Marzo; Leroi V. DeSouza; Eric W. Deutsch; E. Dransfield; Gerard Drewes; Arnaud Droit; Michael J. Dunn; Kojo S.J. Elenitoba-Johnson; Rob M. Ewing; Jennifer E. Van Eyk; Vitor M. Faça; Jayson A. Falkner; Xiangming Fang; Catherine Fenselau; Daniel Figeys; Pierre Gagné; Cecilia Gelfi; Kris Gevaert; Jeffrey M. Gimble; Florian Gnad; Renu Goel; Pavel Gromov; Samir M. Hanash; William S. Hancock; H. C. Harsha; Gerald W. Hart; Faith A. Hays; Fuchu He; Prashantha Hebbar; Kenny Helsens; Heiko Hermeking; Winston Hide; Karin Hjernø; Denis F. Hochstrasser; Oliver Hofmann; David M Horn; Ralph H. Hruban; Nieves Ibarrola; Peter James; Ole N. Jensen; Pia Hønnerup Jensen; Peter Jung; Kumaran Kandasamy; Indu Kheterpal; Reiko F. Kikuno; Ulrike Korf; Roman Körner; Bernhard Kuster; Min-Seok Kwon; Hyoung Joo Lee; Young Jin Lee; Michael Lefevre; Minna Lehvaslaiho; Pierre Lescuyer; Fredrik Levander; Megan S. Lim; Christian Löbke; Joseph A. Loo; Matthias Mann; Lennart Martens; Juan Martínez-Heredia; Mark E. McComb; James P. McRedmond; Alexander Mehrle; Rajasree Menon; Christine A. Miller; Harald Mischak; Subburaman Mohan; Riaz Mohmood; Henrik Molina; Michael Moran; James D. Morgan; Robert Moritz; Martine Morzel; David C. Muddiman; Anuradha Nalli; J. Daniel Navarro; Thomas A. Neubert; Osamu Ohara; Rafael Oliva; Gilbert S. Omenn; Masaaki Oyama; Young Ki Paik; Kyla Pennington; Rainer Pepperkok; Balamurugan Periaswamy; Emanuel F. Petricoin; Guy G. Poirier; T. S. Keshava Prasad; Samuel O. Purvine; B. Abdul Rahiman; Prasanna Ramachandran; Y. L. Ramachandra; Robert H. Rice; Jens Rick; Ragna Rönnholm; Johanna Salonen; Jean-Charles Sanchez; Thierry Sayd; Beerelli Seshi; Kripa Shankari; Shi Jun Sheng; Vivekananda Shetty; K. Shivakumar; Richard J. Simpson; Ravi Sirdeshmukh; K. W. Michael Siu; Jeffrey C. Smith; Richard D. Smith; David J. States; Sumio Sugano; Matthew J. Sullivan; Giulio Superti-Furga; Maarit Takatalo; Visith Thongboonkerd; Jonathan C. Trinidad; Mathias Uhlén; Joël Vandekerckhove; Julian Vasilescu; Timothy D. Veenstra; Jose-Manuel Vidal-Taboada; Mauno Vihinen; Robin Wait; Xiaoyue Wang; Stefan Wiemann; Billy Wu; Tao Xu; John R. Yates; Jun Zhong; Ming Zhou; Yunping Zhu; Petra Zürbig; Akhilesh Pandey;Proteomic technologies, such as yeast two-hybrid, mass spectrometry (MS), protein/peptide arrays and fluorescence microscopy, yield multi-dimensional data sets, which are often quite large and either not published or published as supplementary information that is not easily searchable. Without a system in place for standardizing and sharing data, it is not fruitful for the biomedical community to contribute these types of data to centralized repositories.
Archivio Istituziona... arrow_drop_down Oxford University Research Archive; Nature BiotechnologyArticle . 2008 . 2016License: Springer TDMUniversity of Southern Denmark Research OutputArticle . 2008Data sources: University of Southern Denmark Research OutputHAL - Université de Lille; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2008License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu149 citations 149 popularity Top 10% influence Top 1% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Oxford University Research Archive; Nature BiotechnologyArticle . 2008 . 2016License: Springer TDMUniversity of Southern Denmark Research OutputArticle . 2008Data sources: University of Southern Denmark Research OutputHAL - Université de Lille; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotArticle . 2008License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 FranceMDPI AG ANR | DYNAMO, WTANR| DYNAMO ,WTDelan-Forino, Clémentine; Deforges, Jules; Benard, Lionel; Sargueil, Bruno; Maurel, Marie-Christine; Torchet, Claire;Viroids are small pathogenic circular single-stranded RNAs, present in two complementary sequences, named plus and minus, in infected plant cells. A high degree of complementarities between different regions of the RNAs allows them to adopt complex structures. Since viroids are naked non-coding RNAs, interactions with host factors appear to be closely related to their structural and catalytic characteristics. Avocado sunblotch viroid (ASBVd), a member of the family Avsunviroidae, replicates via a symmetric OPEN ACCESS Viruses 2014, 6 490 RNA-dependant rolling-circle process, involving self-cleavage via hammerhead ribozymes. Consequently, it is assumed that ASBVd plus and minus strands adopt similar structures. Moreover, by computer analyses, a quasi-rod-like secondary structure has been predicted. Nevertheless, secondary and tertiary structures of both polarities of ASBVd remain unsolved. In this study, we analyzed the characteristic of each strand of ASBVd through biophysical analyses. We report that ASBVd transcripts of plus and minus polarities exhibit differences in electrophoretic mobility under native conditions and in thermal denaturation profiles. Subsequently, the secondary structures of plus and minus polarities of ASBVd were probed using the RNA-selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) method. The models obtained show that both polarities fold into different structures. Moreover, our results suggest the existence of a kissing-loop interaction within the minus strand that may play a role in in vivo viroid life cycle. International audience
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/v6020489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/v6020489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, Germany, Spain, Sweden, Finland, United Kingdom, Iceland, United Kingdom, Denmark, Spain, Belgium, United Kingdom, China (People's Republic of), Norway, United Kingdom, Belgium, United Kingdom, Spain, Spain, Netherlands, SwedenSpringer Science and Business Media LLC NWO | Secure and gentle grip of..., NIH | A genome-wide association..., EC | COGS +5 projectsNWO| Secure and gentle grip of delicate biological tissues ,NIH| A genome-wide association study for breast cancer in BRCA1 mutation carriers ,EC| COGS ,CIHR ,WT ,NIH| Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) ,NIH| Elucidating Loci Involved in Prostate Cancer Suceptibility ,NIH| Discovery Expansion and ReplicationFergus J. Couch; Kyriaki Michailidou; Gustavo Mendoza-Fandiño; Silje Nord; Janna Lilyquist; Curtis Olswold; Habibul Ahsan; Kristiina Aittomäki; Christine B. Ambrosone; Irene L. Andrulis; Hoda Anton-Culver; Brita Arver; Monica Barile; Rosa B. Barkardottir; Daniel Barrowdale; Lars Beckmann; Matthias W. Beckmann; Javier Benitez; Stephanie V. Blank; Carl Blomqvist; Natalia Bogdanova; Stig E. Bojesen; Bernardo Bonanni; Hiltrud Brauch; Hermann Brenner; Barbara Burwinkel; Saundra S. Buys; Trinidad Caldés; Maria A. Caligo; Federico Canzian; Jane Carpenter; Stephen J. Chanock; Wendy K. Chung; Kathleen Claes; Angela Cox; Simon S. Cross; Julie M. Cunningham; Kamila Czene; Mary B. Daly; Francesca Damiola; Hatef Darabi; Miguel de la Hoya; Peter Devilee; Orland Diez; Yuan C. Ding; Riccardo Dolcetti; Cecilia M. Dorfling; Isabel dos-Santos-Silva; Martine Dumont; Alison M. Dunning; Diana Eccles; Hans Ehrencrona; Arif B. Ekici; Heather Eliassen; Jonine Figueroa; Florentia Fostira; W. D. Foulkes; Tara M. Friebel; Eitan Friedman; Debra Frost; Marike Gabrielson; Marilie D. Gammon; Patricia A. Ganz; Judy Garber; Mia M. Gaudet; SA Gayther; Anne-Marie Gerdes; Maya Ghoussaini; Graham G. Giles; Mark S. Goldberg; David E. Goldgar; Anna González-Neira; Mark H. Greene; Pascal Guénel; Marc J. Gunter; Lothar Haeberle; Christopher A. Haiman; Thomas Hansen; Steven N. Hart; Sue Healey; Tuomas Heikkinen; Brian E. Henderson; Frans B. L. Hogervorst; Antoinette Hollestelle; M.J. Hooning; Robert N. Hoover; John L. Hopper; David J. Hunter; Tomasz Huzarski; Evgeny N. Imyanitov; Claudine Isaacs; Paul A. James; Ramunas Janavicius; Uffe Birk Jensen; Esther M. John; Michael Jones; Maria Kabisch; Siddhartha Kar; Beth Y. Karlan; Sofia Khan; Muhammad G. Kibriya; Julia A. Knight; Yon Ko; Irene Konstantopoulou; Veli-Matti Kosma; Vessela N. Kristensen; Ava Kwong; Yael Laitman; Diether Lambrechts; Conxi Lázaro; Eunjung Lee; Jenny Lester; Annika Lindblom; S. Lindstrom; Jianjun Liu; Jirong Long; Jan Lubinski; Phuong L. Mai; Enes Makalic; Kathleen E. Malone; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Lesley McGuffog; Alfons Meindl; Austin Miller; Roger L. Milne; Penelope Miron; Marco Montagna; Sylvie Mazoyer; Anna Marie Mulligan; Taru A. Muranen; Katherine L. Nathanson; Susan L. Neuhausen; Heli Nevanlinna; Børge G. Nordestgaard; Robert L. Nussbaum; Kenneth Offit; Olufunmilayo I. Olopade; Janet E. Olson; Ana Osorio; Sue K. Park; Petra H.M. Peeters; Bernard Peissel; Paolo Peterlongo; Julian Peto; Bruce Poppe; Katri Pylkäs; Paolo Radice; Nazneen Rahman; Christine Rappaport; Gad Rennert; Andrea L. Richardson; Mark E. Robson; Isabelle Romieu; Anja Rudolph; María José Sánchez; Regina M. Santella; Elinor J. Sawyer; Daniel F. Schmidt; Marjanka K. Schmidt; Rita K. Schmutzler; Fredrick R. Schumacher; Rodney J. Scott; Leigha Senter; Priyanka Sharma; Jacques Simard; Christian F. Singer; Olga M. Sinilnikova; Melissa C. Southey; Doris Steinemann; Marie Stenmark-Askmalm; Dominique Stoppa-Lyonnet; Anthony J. Swerdlow; Csilla I. Szabo; Rulla M. Tamimi; William J. Tapper; Manuel R. Teixeira; Soo-Hwang Teo; Mary Beth Terry; Mads Thomassen; D Thompson; Laima Tihomirova; Amanda E. Toland; Robert A.E.M. Tollenaar; Ian Tomlinson; Thérèse Truong; Helen Tsimiklis; Alex Teulé; Rosario Tumino; Nadine Tung; Clare Turnbull; Giski Ursin; Elizabeth J. van Rensburg; Raymonda Varon-Mateeva; Zhaoming Wang; Elisabete Weiderpass; Jeffrey N. Weitzel; Alice S. Whittemore; Hans Wildiers; Robert Winqvist; Xiaohong R. Yang; Drakoulis Yannoukakos; Song Yao; M. Pilar Zamora; Per Hall; Peter Kraft; Susan L. Slager; Georgia Chenevix-Trench; Alvaro A.N. Monteiro; Montserrat Garcia-Closas; Douglas F. Easton;handle: 1765/81552 , 1854/LU-7900406 , 10037/10393 , 1887/113206 , 20.500.11820/11e3b572-7147-4e25-85b6-d9cc7351cc4a , 10668/10025 , 2445/126861 , 2336/611194 , 10481/44831 , 10722/226424 , 20.500.12105/7867 , 20.500.12530/26734 , 1874/344341 , 10138/163123
pmid: 27117709
pmc: PMC4853421
handle: 1765/81552 , 1854/LU-7900406 , 10037/10393 , 1887/113206 , 20.500.11820/11e3b572-7147-4e25-85b6-d9cc7351cc4a , 10668/10025 , 2445/126861 , 2336/611194 , 10481/44831 , 10722/226424 , 20.500.12105/7867 , 20.500.12530/26734 , 1874/344341 , 10138/163123
pmid: 27117709
pmc: PMC4853421
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction. ispartof: Nature Communications vol:7 pages:11375- ispartof: location:England status: published
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2018 . 2016License: CC BYRefubium - Repositorium der Freien Universität BerlinArticle . 2016License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryUniversity of Southern Denmark Research OutputArticle . 2016Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTALirias; Oxford University Research Archive; NARCIS; PURE Aarhus University; Ghent University Academic Bibliography; Nature CommunicationsArticle . 2016 . 2018License: CC BYGhent University Academic BibliographyArticle . 2016Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2016Data sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2016License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2017 . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms11375&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu93 citations 93 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 162visibility views 162 download downloads 161 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2018 . 2016License: CC BYRefubium - Repositorium der Freien Universität BerlinArticle . 2016License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryUniversity of Southern Denmark Research OutputArticle . 2016Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTALirias; Oxford University Research Archive; NARCIS; PURE Aarhus University; Ghent University Academic Bibliography; Nature CommunicationsArticle . 2016 . 2018License: CC BYGhent University Academic BibliographyArticle . 2016Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2016Data sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2016License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2017 . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms11375&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 France, Netherlands, Australia, France, ItalyFrontiers Media SA NWO | Diffusion MRI analysis be..., NIH | Axon, Testosterone and Me..., WTNWO| Diffusion MRI analysis beyond connectography ,NIH| Axon, Testosterone and Mental Health during Adolescence ,WTAuthors: Szabolcs David; Anneriet M. Heemskerk; Francesco Corrivetti; Michel Thiebaut de Schotten; +12 AuthorsSzabolcs David; Anneriet M. Heemskerk; Francesco Corrivetti; Michel Thiebaut de Schotten; Silvio Sarubbo; Francesco Corsini; Alessandro De Benedictis; Laurent Petit; Max A. Viergever; Derek K. Jones; Emmanuel Mandonnet; Hubertus Axer; John Evans; Tomáš Paus; Tomáš Paus; Alexander Leemans;International audience; Fiber tractography (FT) using diffusion magnetic resonance imaging (dMRI) is widely used for investigating microstructural properties of white matter (WM) fiber-bundles and for mapping structural connections of the human brain. While studying the architectural configuration of the brain's circuitry with FT is not without controversy, recent progress in acquisition, processing, modeling, analysis, and visualization of dMRI data pushes forward the reliability in reconstructing WM pathways. Despite being aware of the well-known pitfalls in analyzing dMRI data and several other limitations of FT discussed in recent literature, we present the superoanterior fasciculus (SAF), a novel bilateral fiber tract in the frontal region of the human brain that-to the best of our knowledge-has not been documented. The SAF has a similar shape to the anterior part of the cingulum bundle, but it is located more frontally. To minimize the possibility that these FT findings are based on acquisition or processing artifacts, different dMRI data sets and processing pipelines have been used to describe the SAF. Furthermore, we evaluated the configuration of the SAF with complementary methods, such as polarized light imaging (PLI) and human brain dissections. The FT results of the SAF demonstrate a long pathway, consistent across individuals, while the human dissections indicate fiber pathways connecting the postero-dorsal with the antero-dorsal cortices of the frontal lobe.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnana.2019.00024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 5 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnana.2019.00024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Netherlands, Denmark, United Kingdom, FranceAmerican Diabetes Association WTWTDanne, Thomas; Nimri, Revital; Battelino, Tadej; Bergenstal, Richard M.; Close, Kelly L.; DeVries, J. Hans; Garg, Satish; Heinemann, Lutz; Hirsch, Irl; Amiel, Stephanie A.; Beck, Roy; Bosi, Emanuele; Buckingham, Bruce; Cobelli, Claudio; Dassau, Eyal; Doyle, Francis J.; Heller, Simon; Hovorka, Roman; Jia, Weiping; Jones, Tim; Kordonouri, Olga; Kovatchev, Boris; Kowalski, Aaron; Laffel, Lori; Maahs, David; Murphy, Helen R.; Nørgaard, Kirsten; Parkin, Christopher G.; Renard, Eric; Saboo, Banshi; Scharf, Mauro; Tamborlane, William V.; Weinzimer, Stuart A.; Phillip, Moshe;Measurement of glycated hemoglobin (HbA1c) has been the traditional method for assessing glycemic control. However, it does not reflect intra- and interday glycemic excursions that may lead to acute events (such as hypoglycemia) or postprandial hyperglycemia, which have been linked to both microvascular and macrovascular complications. Continuous glucose monitoring (CGM), either from real-time use (rtCGM) or intermittently viewed (iCGM), addresses many of the limitations inherent in HbA1c testing and self-monitoring of blood glucose. Although both provide themeans to move beyond the HbA1c measurement as the sole marker of glycemic control, standardized metrics for analyzing CGM data are lacking. Moreover, clear criteria for matching people with diabetes to themost appropriate glucose monitoring methodologies, as well as standardized advice about howbest to use the new information they provide, have yet to be established. In February 2017, the Advanced Technologies & Treatments for Diabetes (ATTD) Congress convened an international panel of physicians, researchers, and individuals with diabetes who are expert in CGM technologies to address these issues. This article summarizes the ATTD consensus recommendations and represents the current understanding of how CGM results can affect outcomes.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2337/dc17-1600&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1K citations 1,363 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 25visibility views 25 download downloads 161 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu