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description Publication2017Neriman Yilmaz; Robert A. Samson; František Sklenář; Nina Gunde-Cimerman; Jens Frisvad; Monika Coton; Vit Hubka; Cobus M Visagie;Aspergillus section Restricti together with sister section Aspergillus (formerly Eurotium) comprises xerophilic species, that are able to grow on substrates with low water activity and in extreme environments. We adressed the monophyly of both sections within subgenus Aspergillus and applied a multidisciplinary approach for definition of species boundaries in sect. Restricti. The monophyly of sections Aspergillus and Restricti was tested on a set of 102 isolates comprising all currently accepted species and was strongly supported by Maximum likelihood (ML) and Bayesian inferrence (BI) analysis based on β-tubulin (benA), calmodulin (CaM) and RNA polymerase II second largest subunit (RPB2) loci. More than 300 strains belonging to sect. Restricti from various isolation sources and four continents were characterized by DNA sequencing, and 193 isolates were selected for phylogenetic analyses and phenotypic studies. Species delimitation methods based on multispecies coalescent model were employed on DNA sequences from four loci, i.e., ID region of rDNA (ITS + 28S), CaM, benA and RPB2, and supported recognition of 21 species, including 14 new. All these species were also strongly supported in ML and BI analyses. All recognised species can be reliably identified by all four examined genetic loci. Phenotype analysis was performed to support the delimitation of new species and includes colony characteristics on seven cultivation media incubated at several temperatures, growth on an osmotic gradient (six media with NaCl concentration from 0 to 25 %) and analysis of morphology including scanning electron microscopy. The micromorphology of conidial heads, vesicle dimensions, temperature profiles and growth parameters in osmotic gradient were useful criteria for species identification. The vast majority of species in sect. Restricti produce asperglaucide, asperphenamate or both in contrast to species in sect. Aspergillus. Mycophenolic acid was detected for the first time in at least six members of the section. The ascomata of A. halophilicus do not contain auroglaucin, epiheveadride or flavoglaucin which are common in sect. Aspergillus, but shares the echinulins with sect. Aspergillus.
OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu68 citations 68 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Authors: Karin Wuertz-Kozak; Sonja Haeckel; Sebastian Wangler; Christina Wapp;Karin Wuertz-Kozak; Sonja Haeckel; Sebastian Wangler; Christina Wapp;AbstractBackgroundMesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors. This secretome holds immunomodulatory and regenerative capacities. In intervertebral disc (IVD) cells, application of MSC secretome has been shown to decrease the apoptosis rate, induce proliferation, and promote production of extracellular matrix (ECM). For clinical translation of secretome-based treatment, characterization of the secretome composition is needed to better understand the induced biological processes and identify potentially effective secretomes.MethodsThis study aimed to investigate the proteome released by bone marrow-derived MSCs following exposure to a healthy, traumatic, or degenerative human IVD environment by mass spectroscopy and quantitative immunoassay analyses. Exposure of MSCs to the proinflammatory stimulus interleukin 1β (IL-1β) was used as control.ResultsCompared to MSC baseline secretome, there were 224 significantly up- or downregulated proteins following healthy, 179 following traumatic, 223 following degenerative IVD, and 160 proteins following IL-1β stimulus. Stimulation of MSCs with IVD conditioned media induced a more complex MSC secretome, involving more biological processes, compared to stimulation with IL-1β. The MSC response to stimulation with IVD conditioned medium was dependent on their pathological status.ConclusionsThe MSC secretome seemed to match the primary need of the IVD: homeostasis maintenance in the case of healthy IVDs, versus immunomodulation, adjustment of ECM synthesis and degradation disbalance, and ECM (re) organization in the case of traumatic and degenerative IVDs. These findings highlight the importance of cell preconditioning in the development of tailored secretome therapies.Graphical abstractThe secretome of human bone marrow-derived mesenchymal stromal cells (MSCs) stimulated with intervertebral disc (IVD) conditioned medium was analyzed by proteomic profiling. Depending on the pathological state of the IVD, the MSC secretome protein composition indicated immunomodulatory or anabolic activity of the secretome. These findings may have implications for tailored secretome therapy for the IVD and other tissues.
Stem Cell Research &... arrow_drop_down Stem Cell Research & Therapy; OpenAPC Global InitiativeArticle . Conference object . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Stem Cell Research &... arrow_drop_down Stem Cell Research & Therapy; OpenAPC Global InitiativeArticle . Conference object . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017Javier Martin; Pär Hallberg; Reinhold Kreutz; Mats Bengtsson; Patrik Magnusson; MARIA-ISABEL JIMENEZ-SERRANIA; Luisa Ibáñez; Mia Wadelius;doi: 10.1002/cpt.805
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. We performed a genome‐wide association study comprising 9,380,034 polymorphisms and 180 HLA alleles in 36 cases of sulfasalazine‐induced agranulocytosis and 5,170 population controls. Sulfasalazine‐induced agranulocytosis was significantly associated with the HLA region on chromosome 6. The top hit (rs9266634) was located close to HLA‐B, odds ratio (OR) 5.36 (95% confidence interval (CI) (2.97, 9.69) P = 2.55 × 10−8). We HLA‐sequenced a second cohort consisting of 40 cases and 142 treated controls, and confirmed significant associations with HLA‐B*08:01, OR = 2.25 (95% CI (1.02, 4.97) P = 0.0439), in particular the HLA‐B*08:01 haplotype HLA‐DQB1*02:01‐DRB1*03:01‐B*08:01‐C*07:01, OR = 3.79 (95% CI (1.63, 8.80) P = 0.0019), and with HLA‐A*31:01, OR = 4.81 (95% CI (1.52, 15.26) P = 0.0077). The number needed to test for HLA‐B*08:01 and HLA‐A*31:01 to avoid one case was estimated to be 1,500. We suggest that intensified monitoring or alternative treatment should be considered for known carriers of HLA‐B*08:01 or HLA‐A*31:01.
Clinical Pharmacolog... arrow_drop_down Clinical Pharmacology & Therapeutics; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Clinical Pharmacolog... arrow_drop_down Clinical Pharmacology & Therapeutics; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/cpt.805&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017David Garcia-Nieto; John Philip Burrows; Laura Gomez; Richard Querel; Alfonso Saiz-Lopez; Wolfgang Michael Helmut Stremme; Margarita Yela González; Alkiviadis Bais; Andreas Richter; Mónica Navarro-Comas; Nuria Benavent; Carlos Alberto Cuevas Rodríguez; Claudia Ines Rivera Cardenas; Shanshan Wang; Oleg Postylyakov; Tim Bösch; Gaia Pinardi; Kimberly Strong; Muhammad Fahim Khokhar; Olga Puentedura; Enno Peters; Theodore Koenig; Alexander Borovski; Ilya Bruchkouski;Abstract. The differential optical absorption spectroscopy (DOAS) method is a well-known remote sensing technique that is nowadays widely used for measurements of atmospheric trace gases, creating the need for harmonization and characterization efforts. In this study, an intercomparison exercise of DOAS retrieval codes from 17 international groups is presented, focusing on NO2 slant columns. The study is based on data collected by one instrument during the Multi-Axis DOAS Comparison campaign for Aerosols and Trace gases (MAD-CAT) in Mainz, Germany, in summer 2013. As data from the same instrument are used by all groups, the results are free of biases due to instrumental differences, which is in contrast to previous intercomparison exercises.While in general an excellent correlation of NO2 slant columns between groups of > 99.98 % (noon reference fits) and > 99.2 % (sequential reference fits) for all elevation angles is found, differences between individual retrievals are as large as 8 % for NO2 slant columns and 100 % for rms residuals in small elevation angles above the horizon.Comprehensive sensitivity studies revealed that absolute slant column differences result predominantly from the choice of the reference spectrum while relative differences originate from the numerical approach for solving the DOAS equation as well as the treatment of the slit function. Furthermore, differences in the implementation of the intensity offset correction were found to produce disagreements for measurements close to sunrise (8–10 % for NO2, 80 % for rms residual). The largest effect of ≈ 8 % difference in NO2 was found to arise from the reference treatment; in particular for fits using a sequential reference. In terms of rms fit residual, the reference treatment has only a minor impact. In contrast, the wavelength calibration as well as the intensity offset correction were found to have the largest impact (up to 80 %) on rms residual while having only a minor impact on retrieved NO2 slant columns.
Atmospheric Measurem... arrow_drop_down Atmospheric Measurement Techniques; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Atmospheric Measurem... arrow_drop_down Atmospheric Measurement Techniques; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/amt-10-955-2017&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2012American Thoracic Society Nadzeya Marozkina; Khalequz Zaman; Vitali I. Stsiapura; Alix Paget-Brown; Scott Dwyer; Michael D. Davis; Stephen J. Lewis; Sally E. Wenzel; Serpil C. Erzurum; W. G. Teague; Suzy A.A. Comhair; Benjamin Gaston;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 EC | BLUEPRINT, NIH | Institute for Clinical an..., NIH | MESA Family Study - Colum... +60 projectsEC| BLUEPRINT ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| MESA Family Study - Columbia University Field Center ,NIH| DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION-260962103 ,NIH| MESA Family Study ,NIH| Genetic Determinants of Visceral Adiposity ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| Diabetes Endocrinology Research Center ,NIH| MESA Family Study ,NIH| INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS) ,AKA| Atherosclerosis, insulin resistance and diabetic macroangiopathy ,EC| CHANCES ,NIH| HEALTH ABC--COORDINATING UNIT-260962106 ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NIH| SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-268995159 ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| UCLA Clinical and Translational Science Institute ,NIH| Genomes and Genetics at the BCM-HGSC ,WT| Genetics and genomics of central obesity . ,NIH| Genetic Epidemiology of Metabolic Diseases of Obesity ,EC| SEPI ,NIH| Building on GWAS for NHLBI-disease: the CHARGE consortium ,NIH| CHS-Transition Phase -268055222 ,NIH| Epidemiology of Precursors to Type 2 Diabetes ,NIH| TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS) ,AKA| Identification of new genes for type 2 diabetes ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING ,NIH| Multi-Ethnic Study of Atherosclerosis (MESA) Study ,NIH| GWAS of longitudinal blood pressure profiles from young adulthood to middle-age ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,WT| Identification and functional analysis of susceptibility genes in multi- factorial diseases ,NIH| Insulin Clearance: Candidate and Positional Genetic Determinants ,NIH| GENOMIC SCAN FOR ATHEROSCLEROSIS PATHWAY GENES IN AFRICAN-AMERICANS FROM FHS-SCAN ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,EC| EPIGENESYS ,SNSF| Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey ,NIH| DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101 ,NWO| Development of algorithms and software for high-performance computing in genetic analysis of complex human traits ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| Genetic variation in drug targets for type 2 diabetes ,NIH| INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS) ,NIH| Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis ,NIH| Rare Sequence Variation and Diabetes Quantitative Traits ,NIH| Nonparametric methods for functional and translational genomics ,NIH| Genome wide SNP analysis in Neurological disorders ,NIH| MESA Family Study ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,NIH| Targeted Genetic Analysis of T2D and Quantitative Traits ,NIH| CORONARY HEART DISEASE AND STROKE ,UKRI| Aetiology of type 2 diabetes and obesity and related metabolic disorders ,NIH| Discovery of Mendelian Dyslipidemia and Heart Attack Genes Using Exome Sequencing ,NIH| CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS ,WT| Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians. ,NIH| MESA Family Study ,UKRI| Identification of genetic variants underlying Type 2 Diabetes in UK Indian AsiansE Shyong Tai; Nathan Bihlmeyer; Nicholette Allred; Ruth Loos; Dhananjay Vaidya; Nicola Kerrison; Oluf Pedersen; Paul Franks; James Pankow; Stephen Sharp; Panos Deloukas; Giovanni Gambaro; Sara grioni; Ozren Polasek; Sandosh Padmanabhan; Blair Smith; Albert Vernon Smith; Cornelia Van Duijn; Matthias B. Schulze; Ching-Yu Cheng; Nicole Soranzo; Andrew Hattersley; Igor Rudan; Abbas Dehghan; Laura Rasmussen-Torvik; Karina Meidtner; Eirini Marouli; Najaf Amin; Tien Y Wong; Giovanni Malerba; Man Li; Ravinder Abrol; Carlotta Sacerdote; Kristine Højgaard Allin; Rona Strawbridge; Josee Dupuis; Yuning Chen; Torben Jørgensen; Elio Riboli; Marjolein Peters; stephen o'rahilly; Kim Overvad; Torben Hansen; Jennifer Ann Smith; Eleftheria Zeggini; Jennifer Wessel; Alena Yaluri; Chiea Chuen Khor; Hugh Watkins; Daniel Levy; Alanna Morrison; Marie-France Hivert; Claudia Schurmann; Johanna Jakobsdottir; Stephen Rich; Marit Eika Jørgensen; Oscar Franco; Claudia Langenberg; Hanieh null; Cecilia Lindgren; Angela Silveira; Allan Linneberg; L. Adrienne Cupples; ANASTASIA THANOPOULOU; Rasika mathias; Sundas Javad; Jette Bork-Jensen; Maria Sabater Lleal; Vilmundur Gudnason; Tibor V. Varga; Niels Grarup; Marco Dauriz; Anuj Goel; Nita Forouhi; André G Uitterlinden;doi: 10.1038/ncomms6897
AbstractFasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=−0.09±0.01 mmol l−1, P=3.4 × 10−12), T2D risk (OR[95%CI]=0.86[0.76–0.96], P=0.010), early insulin secretion (β=−0.07±0.035 pmolinsulin mmolglucose−1, P=0.048), but higher 2-h glucose (β=0.16±0.05 mmol l−1, P=4.3 × 10−4). We identify a gene-based association with FG at G6PC2 (pSKAT=6.8 × 10−6) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF=20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (β=0.02±0.004 mmol l−1, P=1.3 × 10−8). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
OpenAPC Global Initi... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu168 citations 168 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert OpenAPC Global Initi... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms6897&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Authors: Yolanda Hedberg; Heng-Yong Nie; Valentin Romanovski; Elena Romanovskaia;Yolanda Hedberg; Heng-Yong Nie; Valentin Romanovski; Elena Romanovskaia;doi: 10.1116/6.0000910
Gold (Au) nanoparticles (NPs) are widely used in nanomedical applications as a carrier for molecules designed for different functionalities. Previous findings suggested that biological molecules, including amino acids, could contribute to the dissolution of Au NPs in physiological environments and that this phenomenon was size-dependent. We, therefore, investigated the interactions of L-cysteine with 5-nm Au NPs by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS). This was achieved by loading Au NPs on a clean aluminum (Al) foil and immersing it in an aqueous solution containing L-cysteine. Upon rinsing off the excessive cysteine molecules, ToF-SIMS confirmed the formation of gold cysteine thiolate via the detection of not only the Au–S bond but also the hydrogenated gold cysteine thiolate molecular ion. The presence of NaCl or a 2-(N-morpholino)ethanesulfonic acid buffer disabled the detection of Au NPs on the Al foil. The detection of larger (50-nm) Au NPs was possible but resulted in weaker cysteine and gold signals, and no detected gold cysteine thiolate signals. Nano-gold specific adsorption of L-cysteine was also demonstrated by cyclic voltammetry using paraffine-impregnated graphite electrodes with deposited Au NPs. We demonstrate that the superior chemical selectivity and surface sensitivity of ToF-SIMS, via detection of elemental and molecular species, provide a unique ability to identify the adsorption of cysteine and formation of gold–cysteine bonds on Au NPs.
Biointerphases arrow_drop_down Biointerphases; OpenAPC Global InitiativeArticle . Conference object . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1116/6.0000910&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Biointerphases arrow_drop_down Biointerphases; OpenAPC Global InitiativeArticle . Conference object . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1116/6.0000910&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Tove Fall; Johan Ärnlöv; Jessica Prenni; Xia Shen; Vilmantas Giedraitis; Christoph Nowak; Johan Sundstrom; Samira Salihovic; Naomi Cook; Andrea Ganna;AbstractInsulin resistance (IR) predisposes to type 2 diabetes and cardiovascular disease but its causes are incompletely understood. Metabolic challenges like the oral glucose tolerance test (OGTT) can reveal pathogenic mechanisms. We aimed to discover associations of IR with metabolite trajectories during OGTT. In 470 non-diabetic men (age 70.6 ± 0.6 years), plasma samples obtained at 0, 30 and 120 minutes during an OGTT were analyzed by untargeted liquid chromatography-mass spectrometry metabolomics. IR was assessed with the hyperinsulinemic-euglycemic clamp method. We applied age-adjusted linear regression to identify metabolites whose concentration change was related to IR. Nine trajectories, including monounsaturated fatty acids, lysophosphatidylethanolamines and a bile acid, were significantly associated with IR, with the strongest associations observed for medium-chain acylcarnitines C10 and C12, and no associations with L-carnitine or C2-, C8-, C14- or C16-carnitine. Concentrations of C10- and C12-carnitine decreased during OGTT with a blunted decline in participants with worse insulin resistance. Associations persisted after adjustment for obesity, fasting insulin and fasting glucose. In mouse 3T3-L1 adipocytes exposed to different acylcarnitines, we observed blunted insulin-stimulated glucose uptake after treatment with C10- or C12-carnitine. In conclusion, our results identify medium-chain acylcarnitines as possible contributors to IR.
Scientific Reports; ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu44 citations 44 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 4visibility views 4 download downloads 0 Powered bymore_vert Scientific Reports; ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2019BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health Authors: Paul Mullane; Mary O'Mahony;Paul Mullane; Mary O'Mahony;Background/Aims The benefits of breastfeeding for the mother-infant dyad are recognised. Every effort should be made to encourage and facilitate women to breastfeed successfully. The use of alcohol in the context of breastfeeding is the subject of debate. Guidance can be conflicting and a potential source of confusion. The HSE Alcohol Programme requested public health expertise to undertake a review of the evidence to provide clarity for women. Low-risk alcohol consumption was the context ( Key literature was assessed around a number of themes: Alcohol concentration in breast milk and time to elimination Level of potential alcohol exposure in the breastfeeding infant Effects on infant feeding, sleep and neurodevelopment Methods A research request was made through the HSE Library Service to source relevant literature. Keywords in the search strategy included ‘breastfeeding’, ‘breast milk’, ‘alcohol’, ‘ethanol’, ‘infant’, ‘paediatric’. Multiple databases were searched: Scopus, Pubmed, Embase, Web of Science, Cochrane, Cinahl, PsycINFO, Science Direct, and Clinical Key. Titles and abstracts were assessed against pre-specified inclusion criteria. Full-text articles for studies meeting the inclusion criteria were retrieved for in-depth review. CASP checklists were used to assess study quality. Results 3 systematic reviews and 27 observational studies were identified. Alcohol level peaks in breast milk about 30–60 minutes post-ingestion. 2 hours required, on average, to metabolise 1 standard drink. Breast milk will contain alcohol until this time has elapsed. If an infant were fed at peak alcohol concentration it will receive only about 3% of the maternal ‘dose’. No significant effect on the amount the infant drinks at the breast. It may result in more interrupted infant sleep. No effect on neurodevelopment. Key messages Avoid alcohol in the first month postpartum as feeding is very frequent and it takes time to establish a routine. For women breastfeeding beyond 1 month: - Continue to adhere to guidance on low-risk alcohol consumption. - Feed your baby before having a drink. - Express milk before drinking alcohol. This will allow you to feed your baby if they need feeding before you are ready. Conclusion This review provides an important update to HSE advice on alcohol use and breastfeeding. Our findings have since been incorporated into new user-friendly guidance, available at askaboutalcohol.ie, breastfeeding.ie and the recently launched mychild.ie. The information presented is consistent throughout to ensure robust, clear and transparent advice.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/archdischild-2019-epa.651&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2016European Respiratory Society (ERS) Joshua Lawson; Grzegorz Brożek; Andrei Shpakou; Olga Fedortsiv; Vakhtangi Beridze; Emilija Vlaski; Donna C. Rennie; Anna Afanasieva; Jan E Zejda;Background and Objective : There is variation in childhood asthma between countries with typically higher prevalence in “Westernized” nations. We compared asthma prevalence in Eastern and Central European regions and Canada. Methods : We conducted a cross-sectional survey study investigating the lung health of children (5-15 years). Participants were from one urban centre (>150,000 inhabitants) in each of Canada, Belarus, Poland, Republic of Georgia (Adjara), Republic of Macedonia, and Ukraine. Surveys were distributed through randomly selected schools to parents between 2013 and 2015. A history of diagnosed asthma, ever wheeze, and medication use was assessed. Results : The prevalence of asthma differed by country (Canada: 20.6%; Poland: 13.1%; Macedonia: 2.3%; Belarus: 1.9%; Georgia (Adjara): 1.8%; Ukraine: 1.5%; p Conclusions : While there were large differences in asthma prevalence, respiratory morbidity was more comparable between countries suggesting asthma prevalence may be underestimated and further validation of asthma diagnosis is needed.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publication2017Neriman Yilmaz; Robert A. Samson; František Sklenář; Nina Gunde-Cimerman; Jens Frisvad; Monika Coton; Vit Hubka; Cobus M Visagie;Aspergillus section Restricti together with sister section Aspergillus (formerly Eurotium) comprises xerophilic species, that are able to grow on substrates with low water activity and in extreme environments. We adressed the monophyly of both sections within subgenus Aspergillus and applied a multidisciplinary approach for definition of species boundaries in sect. Restricti. The monophyly of sections Aspergillus and Restricti was tested on a set of 102 isolates comprising all currently accepted species and was strongly supported by Maximum likelihood (ML) and Bayesian inferrence (BI) analysis based on β-tubulin (benA), calmodulin (CaM) and RNA polymerase II second largest subunit (RPB2) loci. More than 300 strains belonging to sect. Restricti from various isolation sources and four continents were characterized by DNA sequencing, and 193 isolates were selected for phylogenetic analyses and phenotypic studies. Species delimitation methods based on multispecies coalescent model were employed on DNA sequences from four loci, i.e., ID region of rDNA (ITS + 28S), CaM, benA and RPB2, and supported recognition of 21 species, including 14 new. All these species were also strongly supported in ML and BI analyses. All recognised species can be reliably identified by all four examined genetic loci. Phenotype analysis was performed to support the delimitation of new species and includes colony characteristics on seven cultivation media incubated at several temperatures, growth on an osmotic gradient (six media with NaCl concentration from 0 to 25 %) and analysis of morphology including scanning electron microscopy. The micromorphology of conidial heads, vesicle dimensions, temperature profiles and growth parameters in osmotic gradient were useful criteria for species identification. The vast majority of species in sect. Restricti produce asperglaucide, asperphenamate or both in contrast to species in sect. Aspergillus. Mycophenolic acid was detected for the first time in at least six members of the section. The ascomata of A. halophilicus do not contain auroglaucin, epiheveadride or flavoglaucin which are common in sect. Aspergillus, but shares the echinulins with sect. Aspergillus.
OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.simyco.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu68 citations 68 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert OpenAPC Global Initi... arrow_drop_down OpenAPC Global Initiative; Studies in MycologyArticle . Conference object . 2017License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.simyco.2017.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Authors: Karin Wuertz-Kozak; Sonja Haeckel; Sebastian Wangler; Christina Wapp;Karin Wuertz-Kozak; Sonja Haeckel; Sebastian Wangler; Christina Wapp;AbstractBackgroundMesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors. This secretome holds immunomodulatory and regenerative capacities. In intervertebral disc (IVD) cells, application of MSC secretome has been shown to decrease the apoptosis rate, induce proliferation, and promote production of extracellular matrix (ECM). For clinical translation of secretome-based treatment, characterization of the secretome composition is needed to better understand the induced biological processes and identify potentially effective secretomes.MethodsThis study aimed to investigate the proteome released by bone marrow-derived MSCs following exposure to a healthy, traumatic, or degenerative human IVD environment by mass spectroscopy and quantitative immunoassay analyses. Exposure of MSCs to the proinflammatory stimulus interleukin 1β (IL-1β) was used as control.ResultsCompared to MSC baseline secretome, there were 224 significantly up- or downregulated proteins following healthy, 179 following traumatic, 223 following degenerative IVD, and 160 proteins following IL-1β stimulus. Stimulation of MSCs with IVD conditioned media induced a more complex MSC secretome, involving more biological processes, compared to stimulation with IL-1β. The MSC response to stimulation with IVD conditioned medium was dependent on their pathological status.ConclusionsThe MSC secretome seemed to match the primary need of the IVD: homeostasis maintenance in the case of healthy IVDs, versus immunomodulation, adjustment of ECM synthesis and degradation disbalance, and ECM (re) organization in the case of traumatic and degenerative IVDs. These findings highlight the importance of cell preconditioning in the development of tailored secretome therapies.Graphical abstractThe secretome of human bone marrow-derived mesenchymal stromal cells (MSCs) stimulated with intervertebral disc (IVD) conditioned medium was analyzed by proteomic profiling. Depending on the pathological state of the IVD, the MSC secretome protein composition indicated immunomodulatory or anabolic activity of the secretome. These findings may have implications for tailored secretome therapy for the IVD and other tissues.
Stem Cell Research &... arrow_drop_down Stem Cell Research & Therapy; OpenAPC Global InitiativeArticle . Conference object . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13287-020-02062-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Stem Cell Research &... arrow_drop_down Stem Cell Research & Therapy; OpenAPC Global InitiativeArticle . Conference object . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13287-020-02062-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017Javier Martin; Pär Hallberg; Reinhold Kreutz; Mats Bengtsson; Patrik Magnusson; MARIA-ISABEL JIMENEZ-SERRANIA; Luisa Ibáñez; Mia Wadelius;doi: 10.1002/cpt.805
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. We performed a genome‐wide association study comprising 9,380,034 polymorphisms and 180 HLA alleles in 36 cases of sulfasalazine‐induced agranulocytosis and 5,170 population controls. Sulfasalazine‐induced agranulocytosis was significantly associated with the HLA region on chromosome 6. The top hit (rs9266634) was located close to HLA‐B, odds ratio (OR) 5.36 (95% confidence interval (CI) (2.97, 9.69) P = 2.55 × 10−8). We HLA‐sequenced a second cohort consisting of 40 cases and 142 treated controls, and confirmed significant associations with HLA‐B*08:01, OR = 2.25 (95% CI (1.02, 4.97) P = 0.0439), in particular the HLA‐B*08:01 haplotype HLA‐DQB1*02:01‐DRB1*03:01‐B*08:01‐C*07:01, OR = 3.79 (95% CI (1.63, 8.80) P = 0.0019), and with HLA‐A*31:01, OR = 4.81 (95% CI (1.52, 15.26) P = 0.0077). The number needed to test for HLA‐B*08:01 and HLA‐A*31:01 to avoid one case was estimated to be 1,500. We suggest that intensified monitoring or alternative treatment should be considered for known carriers of HLA‐B*08:01 or HLA‐A*31:01.
Clinical Pharmacolog... arrow_drop_down Clinical Pharmacology & Therapeutics; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/cpt.805&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Clinical Pharmacolog... arrow_drop_down Clinical Pharmacology & Therapeutics; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/cpt.805&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017David Garcia-Nieto; John Philip Burrows; Laura Gomez; Richard Querel; Alfonso Saiz-Lopez; Wolfgang Michael Helmut Stremme; Margarita Yela González; Alkiviadis Bais; Andreas Richter; Mónica Navarro-Comas; Nuria Benavent; Carlos Alberto Cuevas Rodríguez; Claudia Ines Rivera Cardenas; Shanshan Wang; Oleg Postylyakov; Tim Bösch; Gaia Pinardi; Kimberly Strong; Muhammad Fahim Khokhar; Olga Puentedura; Enno Peters; Theodore Koenig; Alexander Borovski; Ilya Bruchkouski;Abstract. The differential optical absorption spectroscopy (DOAS) method is a well-known remote sensing technique that is nowadays widely used for measurements of atmospheric trace gases, creating the need for harmonization and characterization efforts. In this study, an intercomparison exercise of DOAS retrieval codes from 17 international groups is presented, focusing on NO2 slant columns. The study is based on data collected by one instrument during the Multi-Axis DOAS Comparison campaign for Aerosols and Trace gases (MAD-CAT) in Mainz, Germany, in summer 2013. As data from the same instrument are used by all groups, the results are free of biases due to instrumental differences, which is in contrast to previous intercomparison exercises.While in general an excellent correlation of NO2 slant columns between groups of > 99.98 % (noon reference fits) and > 99.2 % (sequential reference fits) for all elevation angles is found, differences between individual retrievals are as large as 8 % for NO2 slant columns and 100 % for rms residuals in small elevation angles above the horizon.Comprehensive sensitivity studies revealed that absolute slant column differences result predominantly from the choice of the reference spectrum while relative differences originate from the numerical approach for solving the DOAS equation as well as the treatment of the slit function. Furthermore, differences in the implementation of the intensity offset correction were found to produce disagreements for measurements close to sunrise (8–10 % for NO2, 80 % for rms residual). The largest effect of ≈ 8 % difference in NO2 was found to arise from the reference treatment; in particular for fits using a sequential reference. In terms of rms fit residual, the reference treatment has only a minor impact. In contrast, the wavelength calibration as well as the intensity offset correction were found to have the largest impact (up to 80 %) on rms residual while having only a minor impact on retrieved NO2 slant columns.
Atmospheric Measurem... arrow_drop_down Atmospheric Measurement Techniques; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/amt-10-955-2017&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Atmospheric Measurem... arrow_drop_down Atmospheric Measurement Techniques; OpenAPC Global InitiativeArticle . Conference object . 2017License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/amt-10-955-2017&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2012American Thoracic Society Nadzeya Marozkina; Khalequz Zaman; Vitali I. Stsiapura; Alix Paget-Brown; Scott Dwyer; Michael D. Davis; Stephen J. Lewis; Sally E. Wenzel; Serpil C. Erzurum; W. G. Teague; Suzy A.A. Comhair; Benjamin Gaston;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 EC | BLUEPRINT, NIH | Institute for Clinical an..., NIH | MESA Family Study - Colum... +60 projectsEC| BLUEPRINT ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| MESA Family Study - Columbia University Field Center ,NIH| DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION-260962103 ,NIH| MESA Family Study ,NIH| Genetic Determinants of Visceral Adiposity ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| Diabetes Endocrinology Research Center ,NIH| MESA Family Study ,NIH| INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS) ,AKA| Atherosclerosis, insulin resistance and diabetic macroangiopathy ,EC| CHANCES ,NIH| HEALTH ABC--COORDINATING UNIT-260962106 ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NIH| SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-268995159 ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| UCLA Clinical and Translational Science Institute ,NIH| Genomes and Genetics at the BCM-HGSC ,WT| Genetics and genomics of central obesity . ,NIH| Genetic Epidemiology of Metabolic Diseases of Obesity ,EC| SEPI ,NIH| Building on GWAS for NHLBI-disease: the CHARGE consortium ,NIH| CHS-Transition Phase -268055222 ,NIH| Epidemiology of Precursors to Type 2 Diabetes ,NIH| TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS) ,AKA| Identification of new genes for type 2 diabetes ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING ,NIH| Multi-Ethnic Study of Atherosclerosis (MESA) Study ,NIH| GWAS of longitudinal blood pressure profiles from young adulthood to middle-age ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,WT| Identification and functional analysis of susceptibility genes in multi- factorial diseases ,NIH| Insulin Clearance: Candidate and Positional Genetic Determinants ,NIH| GENOMIC SCAN FOR ATHEROSCLEROSIS PATHWAY GENES IN AFRICAN-AMERICANS FROM FHS-SCAN ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,EC| EPIGENESYS ,SNSF| Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey ,NIH| DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101 ,NWO| Development of algorithms and software for high-performance computing in genetic analysis of complex human traits ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| Genetic variation in drug targets for type 2 diabetes ,NIH| INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS) ,NIH| Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis ,NIH| Rare Sequence Variation and Diabetes Quantitative Traits ,NIH| Nonparametric methods for functional and translational genomics ,NIH| Genome wide SNP analysis in Neurological disorders ,NIH| MESA Family Study ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,NIH| Targeted Genetic Analysis of T2D and Quantitative Traits ,NIH| CORONARY HEART DISEASE AND STROKE ,UKRI| Aetiology of type 2 diabetes and obesity and related metabolic disorders ,NIH| Discovery of Mendelian Dyslipidemia and Heart Attack Genes Using Exome Sequencing ,NIH| CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS ,WT| Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians. ,NIH| MESA Family Study ,UKRI| Identification of genetic variants underlying Type 2 Diabetes in UK Indian AsiansE Shyong Tai; Nathan Bihlmeyer; Nicholette Allred; Ruth Loos; Dhananjay Vaidya; Nicola Kerrison; Oluf Pedersen; Paul Franks; James Pankow; Stephen Sharp; Panos Deloukas; Giovanni Gambaro; Sara grioni; Ozren Polasek; Sandosh Padmanabhan; Blair Smith; Albert Vernon Smith; Cornelia Van Duijn; Matthias B. Schulze; Ching-Yu Cheng; Nicole Soranzo; Andrew Hattersley; Igor Rudan; Abbas Dehghan; Laura Rasmussen-Torvik; Karina Meidtner; Eirini Marouli; Najaf Amin; Tien Y Wong; Giovanni Malerba; Man Li; Ravinder Abrol; Carlotta Sacerdote; Kristine Højgaard Allin; Rona Strawbridge; Josee Dupuis; Yuning Chen; Torben Jørgensen; Elio Riboli; Marjolein Peters; stephen o'rahilly; Kim Overvad; Torben Hansen; Jennifer Ann Smith; Eleftheria Zeggini; Jennifer Wessel; Alena Yaluri; Chiea Chuen Khor; Hugh Watkins; Daniel Levy; Alanna Morrison; Marie-France Hivert; Claudia Schurmann; Johanna Jakobsdottir; Stephen Rich; Marit Eika Jørgensen; Oscar Franco; Claudia Langenberg; Hanieh null; Cecilia Lindgren; Angela Silveira; Allan Linneberg; L. Adrienne Cupples; ANASTASIA THANOPOULOU; Rasika mathias; Sundas Javad; Jette Bork-Jensen; Maria Sabater Lleal; Vilmundur Gudnason; Tibor V. Varga; Niels Grarup; Marco Dauriz; Anuj Goel; Nita Forouhi; André G Uitterlinden;doi: 10.1038/ncomms6897
AbstractFasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=−0.09±0.01 mmol l−1, P=3.4 × 10−12), T2D risk (OR[95%CI]=0.86[0.76–0.96], P=0.010), early insulin secretion (β=−0.07±0.035 pmolinsulin mmolglucose−1, P=0.048), but higher 2-h glucose (β=0.16±0.05 mmol l−1, P=4.3 × 10−4). We identify a gene-based association with FG at G6PC2 (pSKAT=6.8 × 10−6) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF=20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (β=0.02±0.004 mmol l−1, P=1.3 × 10−8). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
OpenAPC Global Initi... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms6897&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu168 citations 168 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert OpenAPC Global Initi... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms6897&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Authors: Yolanda Hedberg; Heng-Yong Nie; Valentin Romanovski; Elena Romanovskaia;Yolanda Hedberg; Heng-Yong Nie; Valentin Romanovski; Elena Romanovskaia;doi: 10.1116/6.0000910
Gold (Au) nanoparticles (NPs) are widely used in nanomedical applications as a carrier for molecules designed for different functionalities. Previous findings suggested that biological molecules, including amino acids, could contribute to the dissolution of Au NPs in physiological environments and that this phenomenon was size-dependent. We, therefore, investigated the interactions of L-cysteine with 5-nm Au NPs by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS). This was achieved by loading Au NPs on a clean aluminum (Al) foil and immersing it in an aqueous solution containing L-cysteine. Upon rinsing off the excessive cysteine molecules, ToF-SIMS confirmed the formation of gold cysteine thiolate via the detection of not only the Au–S bond but also the hydrogenated gold cysteine thiolate molecular ion. The presence of NaCl or a 2-(N-morpholino)ethanesulfonic acid buffer disabled the detection of Au NPs on the Al foil. The detection of larger (50-nm) Au NPs was possible but resulted in weaker cysteine and gold signals, and no detected gold cysteine thiolate signals. Nano-gold specific adsorption of L-cysteine was also demonstrated by cyclic voltammetry using paraffine-impregnated graphite electrodes with deposited Au NPs. We demonstrate that the superior chemical selectivity and surface sensitivity of ToF-SIMS, via detection of elemental and molecular species, provide a unique ability to identify the adsorption of cysteine and formation of gold–cysteine bonds on Au NPs.
Biointerphases arrow_drop_down Biointerphases; OpenAPC Global InitiativeArticle . Conference object . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1116/6.0000910&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Biointerphases arrow_drop_down Biointerphases; OpenAPC Global InitiativeArticle . Conference object . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1116/6.0000910&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Tove Fall; Johan Ärnlöv; Jessica Prenni; Xia Shen; Vilmantas Giedraitis; Christoph Nowak; Johan Sundstrom; Samira Salihovic; Naomi Cook; Andrea Ganna;AbstractInsulin resistance (IR) predisposes to type 2 diabetes and cardiovascular disease but its causes are incompletely understood. Metabolic challenges like the oral glucose tolerance test (OGTT) can reveal pathogenic mechanisms. We aimed to discover associations of IR with metabolite trajectories during OGTT. In 470 non-diabetic men (age 70.6 ± 0.6 years), plasma samples obtained at 0, 30 and 120 minutes during an OGTT were analyzed by untargeted liquid chromatography-mass spectrometry metabolomics. IR was assessed with the hyperinsulinemic-euglycemic clamp method. We applied age-adjusted linear regression to identify metabolites whose concentration change was related to IR. Nine trajectories, including monounsaturated fatty acids, lysophosphatidylethanolamines and a bile acid, were significantly associated with IR, with the strongest associations observed for medium-chain acylcarnitines C10 and C12, and no associations with L-carnitine or C2-, C8-, C14- or C16-carnitine. Concentrations of C10- and C12-carnitine decreased during OGTT with a blunted decline in participants with worse insulin resistance. Associations persisted after adjustment for obesity, fasting insulin and fasting glucose. In mouse 3T3-L1 adipocytes exposed to different acylcarnitines, we observed blunted insulin-stimulated glucose uptake after treatment with C10- or C12-carnitine. In conclusion, our results identify medium-chain acylcarnitines as possible contributors to IR.
Scientific Reports; ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41598-018-26701-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu44 citations 44 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 4visibility views 4 download downloads 0 Powered bymore_vert Scientific Reports; ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2019BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health Authors: Paul Mullane; Mary O'Mahony;Paul Mullane; Mary O'Mahony;Background/Aims The benefits of breastfeeding for the mother-infant dyad are recognised. Every effort should be made to encourage and facilitate women to breastfeed successfully. The use of alcohol in the context of breastfeeding is the subject of debate. Guidance can be conflicting and a potential source of confusion. The HSE Alcohol Programme requested public health expertise to undertake a review of the evidence to provide clarity for women. Low-risk alcohol consumption was the context ( Key literature was assessed around a number of themes: Alcohol concentration in breast milk and time to elimination Level of potential alcohol exposure in the breastfeeding infant Effects on infant feeding, sleep and neurodevelopment Methods A research request was made through the HSE Library Service to source relevant literature. Keywords in the search strategy included ‘breastfeeding’, ‘breast milk’, ‘alcohol’, ‘ethanol’, ‘infant’, ‘paediatric’. Multiple databases were searched: Scopus, Pubmed, Embase, Web of Science, Cochrane, Cinahl, PsycINFO, Science Direct, and Clinical Key. Titles and abstracts were assessed against pre-specified inclusion criteria. Full-text articles for studies meeting the inclusion criteria were retrieved for in-depth review. CASP checklists were used to assess study quality. Results 3 systematic reviews and 27 observational studies were identified. Alcohol level peaks in breast milk about 30–60 minutes post-ingestion. 2 hours required, on average, to metabolise 1 standard drink. Breast milk will contain alcohol until this time has elapsed. If an infant were fed at peak alcohol concentration it will receive only about 3% of the maternal ‘dose’. No significant effect on the amount the infant drinks at the breast. It may result in more interrupted infant sleep. No effect on neurodevelopment. Key messages Avoid alcohol in the first month postpartum as feeding is very frequent and it takes time to establish a routine. For women breastfeeding beyond 1 month: - Continue to adhere to guidance on low-risk alcohol consumption. - Feed your baby before having a drink. - Express milk before drinking alcohol. This will allow you to feed your baby if they need feeding before you are ready. Conclusion This review provides an important update to HSE advice on alcohol use and breastfeeding. Our findings have since been incorporated into new user-friendly guidance, available at askaboutalcohol.ie, breastfeeding.ie and the recently launched mychild.ie. The information presented is consistent throughout to ensure robust, clear and transparent advice.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/archdischild-2019-epa.651&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/archdischild-2019-epa.651&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2016European Respiratory Society (ERS) Joshua Lawson; Grzegorz Brożek; Andrei Shpakou; Olga Fedortsiv; Vakhtangi Beridze; Emilija Vlaski; Donna C. Rennie; Anna Afanasieva; Jan E Zejda;Background and Objective : There is variation in childhood asthma between countries with typically higher prevalence in “Westernized” nations. We compared asthma prevalence in Eastern and Central European regions and Canada. Methods : We conducted a cross-sectional survey study investigating the lung health of children (5-15 years). Participants were from one urban centre (>150,000 inhabitants) in each of Canada, Belarus, Poland, Republic of Georgia (Adjara), Republic of Macedonia, and Ukraine. Surveys were distributed through randomly selected schools to parents between 2013 and 2015. A history of diagnosed asthma, ever wheeze, and medication use was assessed. Results : The prevalence of asthma differed by country (Canada: 20.6%; Poland: 13.1%; Macedonia: 2.3%; Belarus: 1.9%; Georgia (Adjara): 1.8%; Ukraine: 1.5%; p Conclusions : While there were large differences in asthma prevalence, respiratory morbidity was more comparable between countries suggesting asthma prevalence may be underestimated and further validation of asthma diagnosis is needed.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1183/13993003.congress-2016.pa1312&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1183/13993003.congress-2016.pa1312&type=result"></script>'); --> </script>
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