description Publicationkeyboard_double_arrow_right Preprint , Article 2019Cold Spring Harbor Laboratory ARC | Discovery Projects - Gran...ARC| Discovery Projects - Grant ID: DP150101649Stephen D. J. Archer; Kevin Lee; Tancredi Caruso; Katie King-Miaow; Mike Harvey; Danwei Huang; Benjamin J. Wainwright; Stephen B. Pointing;Abstract The atmosphere is the least understood biome on Earth despite its critical role as a microbial transport medium. The influence of surface cover on composition of airborne microbial communities above marine systems is unclear. Here we report evidence for a dynamic microbial presence at the ocean–atmosphere interface of a major marine ecosystem, the Great Barrier Reef, and identify that recent air mass trajectory over an oceanic or continental surface associated with observed shifts in airborne bacterial and fungal diversity. Relative abundance of shared taxa between air and coral microbiomes varied between 2.2 and 8.8% and included those identified as part of the core coral microbiome. We propose that this variable source of atmospheric inputs may in part contribute to the diverse and transient nature of the coral microbiome.
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For further information contact us at helpdesk@openaire.eu31 citations 31 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2023Cold Spring Harbor Laboratory CIHR, ARC | Molecular genetic analyse..., ARC | Genomics of temperature r... +2 projectsCIHR ,ARC| Molecular genetic analyses of trinucleotide repeat expansions ,ARC| Genomics of temperature response in plants ,ARC| Discovery Projects - Grant ID: DP190101818 ,ARC| ARC Future Fellowships - Grant ID: FT190100403Sridevi Sureshkumar; Champa Bandaranayake; Junqing Lu; Craig I Dent; Chhaya Atri; Harrison M York; Prashanth Tamizhselvan; Nawar Shamaya; Giulia Folini; Prakash Kumar Bhagat; Benjamin G Bergey; Avilash Singh Yadav; Subhasree Kumar; Oliver Grummisch; Prince Saini; Ram K Yadav; Senthil Arumugam; Emanuel Rosonina; Ari Sadanandom; Hongtao Liu; Sureshkumar Balasubramanian;Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich’s ataxia in humans1. The molecular mechanisms underlying repeat expansion-induced epigenetic silencing remain largely unknown2,3. Using a plant model, we have previously shown that expanded repeats can induce smallRNAs which in turn can lead to epigenetic silencing through the RNA-dependent DNA methylation pathway4,5. Here, using a genetic suppressor screen, we confirm a key role for the RdDM pathway and identify novel components required for epigenetic silencing caused by expanded repeats. We show that FOURTH ULP LIKE GENE CLASS 1 (FUG1) – a SUMO protease, ALFIN-LIKE 3 – a histone reader and LIKE HETEROCHROMATIN 1 (LHP1) - a component of the PRC1 complex are required for repeat expansion-induced epigenetic silencing. Loss of any of these components suppress repeat expansion-associated phenotypes. SUMO protease FUG1 physically interacts with AL3 and perturbing its potential SUMOylation site disrupts its nuclear localisation. AL3 physically interacts with LHP1 of the PRC1 complex and the FUG1-AL3-LHP1 module is essential to confer repeat expansion-associated epigenetic silencing. Our findings highlight the importance post-translational modifiers and histone readers in epigenetic silencing caused by repeat expansions.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Germany, Ireland, United Kingdom, Netherlands, Italy, Spain, United Kingdom, France, France, France, United Kingdom, France, France, France, United Kingdom, United Kingdom, France, IrelandSpringer Science and Business Media LLC EC | NEUROSCHEMA, NIH | The ARIC and Neurocogniti..., NIH | Functional genomics of bi... +110 projectsEC| NEUROSCHEMA ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| Functional genomics of bipolar disorder ,NIH| OBESITY, DIABETES &AGING ANIMAL RESOURCE ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NHMRC| Cerebrovascular diseases and Brain Ageing – a program of research into novel mechanisms, risk prevention and innovative health care delivery ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NIH| UCLA Clinical and Translational Science Institute ,NIH| HARDI Mapping of Disease Effects on the Brain ,NIH| Predicting Brain Changes in HIV/AIDS ,NSF| MRI: Acquisition of a Data Analytics Cluster for Computational Social Science ,NIH| CHS-Transition Phase -268055222 ,NIH| Searching for Endophenotypes of Bipolar Disorder ,NIH| Alzheimer's Disease Genetics Consortium ,EC| ORACLE ,NWO| Twin-family database for behavior genetics and genomics studies ,NWO| Networking through ADHD biology ,NIH| Alzheimer's Disease Genetics Consortium ,NIH| Empowering Personalized Medicine: Integrating Imaging, Genetics, and Biomarkers ,FWF| Mechanisms of Small Vessel Related Brain Damage and Cognitive Impairment ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,EC| TACTICS ,WT| Stratifying Resilience and Depression Longitudinally (STRADL) ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Genetic Epidemiology of Cognitive Decline in an Aging Population Sample ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NIH| Occult Small Vessel Cerebrovascular Disease in High Risk Families ,NHMRC| Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,EC| EU-AIMS ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,EC| MATRICS ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NIH| GCRC-RENOVATION ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| International Multi-Center ADHD Genetics Project ,NHMRC| A population-based study of cerebrovascular mechanisms underyling gait, balance and cognition in older people ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,EC| PHASE ,NIH| Hormonal trajectories in aging ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults ,CIHR ,NHMRC| Genetics of brain structure and function ,NIH| Epidemiology of Biomarkers of Risk and Progression in LOAD ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,NHMRC| Australian Twin Registry ,NWO| NCHA Subsidiebesluit 2008-2012 ,ARC| The articulate brain ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Genomic Studies of Bipolar Disorder in a Large Cohort from The Netherlands ,NWO| Neuro-imaging study in twins concordant or discordant for obsessive-compulsive symptoms. ,NIH| ALZHEIMERS DISEASE DATA COORDINATING CENTER ,NHMRC| Genetics of melanoma risk factors ,NIH| Structural Brain Abnormalities In Depression ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,NIH| Alzheimer's disease risk analyzed using population imaging genomics ,NHMRC| Prevention and management of mental disorders in older Australians ,NIH| Functional Neuroimaging In Unipolar And Bipolar Depresse ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,NHMRC| Development and Evaluation of Statistical Methods and Software for Analysis of Complex Genetic Disease Data ,NIH| CHS research resources for the cardiovascular health of older adults ,WT| A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease ,NHMRC| Genetic Repositories Australia ,NIH| Genetic Influences on Human Cortical Development ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,ARC| Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| Vascular Cognitive and Motor Decline: Impact of aPL ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,EC| ENGAGE ,NIH| Genetic influences on the brain: A twin imaging study ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,EC| AGGRESSOTYPE ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION ,NIH| Genetic Influences on Human Neuroanatomical Shapes ,NIH| Neurodevelopment and Imaging among HIV-infected Children from the PREDICT study ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY ,NIH| Alzheimers Disease in Mild Cognitive Impairment ,EC| GMI ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| CORONARY HEART DISEASE AND STROKEHieab H.H. Adams; Vincent Chouraki; Jason L. Stein; Miguel E. Rentería; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Sven J. van der Lee; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Owen Carmichael; Ganesh Chauhan; Qiang Chen; Gabriel Cuellar-Partida; Anouk den Braber; Stefan Ehrlich; Irina Filippi; Tian Ge; Rebecca F. Gottesman; Corina U. Greven; Tulio Guadalupe; Unn K. Haukvik; Saima Hilal; D. Hoehn; Tianye Jia; Marieke Klein; Phil H. Lee; David C. Liewald; Lorna M. Lopez; Michelle Luciano; Christine Macare; Andre F. Marquand; Karen A. Mather; Manuel Mattheisen; Bernard Mazoyer; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L. Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Loes M. Olde Loohuis; Jaap Oosterlaan; Irene Pappa; Lukas Pirpamer; Sara Pudas; Adaikalavan Ramasamy; Jennifer S. Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Jean Shin; Albert V. Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutiérrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen van der Grond; Dennis van der Meer; Marjolein M. J. Van Donkelaar; Kristel R. van Eijk; Theo G.M. van Erp; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Ingrid Agartz; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Mark E. Bastin; Diane M. Becker; James T. Becker; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Randy L. Buckner; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Gareth E. Davies; Eco J. C. de Geus; Greig I. Zubicaray; Anita L. DeStefano; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A. Evans; Iryna O. Fedko; Simon E. Fisher; Debra A. Fleischman; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Harald H H Göring; Hans J. Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Ryota Hashimoto; Andreas Heinz; Stephanie Le Hellard; Dirk J. Heslenfeld; Beng-Choon Ho; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Hilleke E. Hulshoff Pol; M. Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; David S. Knopman; Peter Kochunov; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; W.T. Longstreth; Oscar L. Lopez; Simon Lovestone; Jean-Luc Martinot; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Derek W. Morris; Thomas H. Mosley; Thomas W. Mühleisen; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Roel A. Ophoff; Massimo Pandolfo; G. Bruce Pike; Bruce M. Psaty; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Andrew Singleton; Hilkka Soininen; Velandai Srikanth; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W. Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Aad van der Lugt; Nic J A van der Wee; Cornelia M. van Duijn; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W. Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; H. Ronald Zielke; Alan B. Zonderman; Ian J. Deary; Nicholas G. Martin; Anton J. M. de Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Barbara Franke; Stéphanie Debette; Sarah E. Medland; Paul M. Thompson;pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rhogenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. Contains fulltext : 165723pub.pdf (Publisher’s version ) (Closed access)
CORE (RIOXX-UK Aggre... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2016Data sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016License: Springer TDMNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu198 citations 198 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 141visibility views 141 download downloads 458 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2016Data sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016License: Springer TDMNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2017Cold Spring Harbor Laboratory NSF | EID: Collaborative Resear..., ARC | What drives parasite spre..., ARC | Discovery Early Career Re...NSF| EID: Collaborative Research: Invasion and Infection: Translocation and Transmission: An Experimental Study with Mycoplasma in Desert Tortoises ,ARC| What drives parasite spread through social networks: lessons from lizards ,ARC| Discovery Early Career Researcher Award - Grant ID: DE170101132Sah, Pratha; Otterstatter, Michael; Leu, Stephan T.; Leviyang, Sivan; Bansal, Shweta;doi: 10.1101/169573
AbstractThe spread of pathogens fundamentally depends on the underlying contacts between individuals. Modeling infectious disease dynamics through contact networks is sometimes challenging, however, due to a limited understanding of pathogen transmission routes and infectivity. We developed a novel tool, INoDS (Identifying Network models of infectious Disease Spread) that estimates the predictive power of empirical contact networks to explain observed patterns of infectious disease spread. We show that our method is robust to partially sampled contact networks, incomplete disease information, and enables hypothesis testing on transmission mechanisms. We demonstrate the applicability of our method in two host-pathogen systems: Crithidia bombi in bumble bee colonies and Salmonella in wild Australian sleepy lizard populations. The performance of INoDS in synthetic and complex empirical systems highlights its role in identifying transmission pathways of novel or neglected pathogens, as an alternative approach to laboratory transmission experiments, and overcoming common data-collection constraints.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Spain, DenmarkeLife Sciences Publications, Ltd EC | EPICS, ARC | Composition, assembly and..., WTEC| EPICS ,ARC| Composition, assembly and functions of the pellicle of apicomplexan parasites: a structure pivotal to disease transmission and progression ,WTYong H. Woo; Hifzur Rahman Ansari; Thomas D. Otto; Christen M. Klinger; Martin Kolisko; Jan Michálek; Alka Saxena; Dhanasekaran Shanmugam; Annageldi Tayyrov; Alaguraj Veluchamy; Shahjahan Ali; Axel Bernal; Javier del Campo; Jaromír Cihlář; Pavel Flegontov; Sebastian G. Gornik; Eva Hajdušková; Aleš Horák; Jan Janouškovec; Nicholas J. Katris; Fred D. Mast; Diego Miranda-Saavedra; Tobias Mourier; Raeece Naeem; Mridul Nair; Aswini K. Panigrahi; Neil D. Rawlings; Eriko Padron-Regalado; Abhinay Ramaprasad; Nadira Binte Samad; Aleš Tomčala; Jon Wilkes; Daniel E. Neafsey; Christian Doerig; Chris Bowler; Patrick J. Keeling; David S. Roos; Joel B. Dacks; Thomas J. Templeton; Ross F. Waller; Julius Lukeš; Miroslav Oborník; Arnab Pain;doi: 10.7554/elife.06974
handle: 10069/35779 , 10261/133321
The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. King Abdullah University of Science and Technology (KAUST; Council of Scientific and Industrial Research; National Institute of Allergy and Infectious Diseases (NIAID); Australian Research Council (ARC); Monash University; National Health and Medical Research Council (NHMRC); Czech Science Foundation (Grantova´ agentura Ceske´ republiky) Peer Reviewed
eLife arrow_drop_down Copenhagen University Research Information SystemArticle . 2015Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015https://doi.org/10.7554/eLife....Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu215 citations 215 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 22visibility views 22 download downloads 36 Powered bymore_vert eLife arrow_drop_down Copenhagen University Research Information SystemArticle . 2015Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015https://doi.org/10.7554/eLife....Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 WT | A national DNA control se..., NIH | Genetics of Early Onset-S..., NIH | Integration of Genomics &... +99 projectsWT| A national DNA control series for genetic case-control studies based on the British 1958 birth cohort ,NIH| Genetics of Early Onset-Stroke ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| Pharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) Study ,NIH| Molecular Genetics of Schizophrenia ,NIH| CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| Whole Genome Assoc. Analysis Strategies for Multi. Phenotypes ,WT| Genetic studies of the aetiology of human metabolic disease: morbid obesity, obesity, severe insulin resistance and type 2 diabetes. ,NIH| ATN 004: HEALTHY CHOICES: MOTIVATIONAL ENHANCEMENT TO PROMOTE HEALTH AND REDU ,NHMRC| Mapping Genes for typical migraine using twin families. ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| Genetic epidemiology of rare and regulatory variants for metabolic traits ,NIH| A Genome-wide Association Study for Early-Onset Myocardial Infarction ,ARC| Why is most of the genetic variance for complex traits undetected by large powerful screens of common variants? ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NHMRC| Explaining the Dark Matter of Genome-wide Association Studies for Complex Disease ,NIH| Genome-wide Association Study of Schizophrenia ,NIH| Molecular Genetics of Schizophrenia ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,EC| ATHEROREMO ,EC| HYPERGENES ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Pharmacogenomics of CVD risk Reduction ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| Delineating risk factors for the initiation and maintenance of cannabis use, in comparison with tobacco use, in adolescence ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| UCLA Clinical and Translational Science Institute ,EC| EPI-MIGRANT ,EC| COPACETIC ,NIH| OSTEOARTHRITIS OF THE KNEE AND HIP IN JOHNSON COUNTY ,NIH| Type 1 Diabetes Genetics Consortium ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| CCSP - FIELD CENTER AND ULTRASOUND READING CENTER ,NIH| TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN ,EC| EURHEALTHAGEING ,WT| The genetics of weight, BMI, adiposity and obesity ,NHMRC| Investigating the role of pigmentation pathway genes in moliness and melanoma risk ,EC| GMI ,EC| EPLORE ,NIH| Identifying Genes for Type 2 Diabetes: FUSION ,NIH| AN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORK ,NIH| Genetic Architecture of Adiposity in Multiple Large Cohorts ,NWO| Tracking Emerging Adults, the fifth wave of the TRAILS study ,NIH| Data Mgmt &Analysis Core - The NINDS International Stroke Genetics Consortium St ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NHMRC| Genetics of melanoma risk factors ,NIH| COMMUNITY AND COHORT SURVEILLANCE PROGRAMS ,NIH| Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,WT| Whole genome strategies for detecting and characterizing complex trait loci. ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,NIH| CCSP-FIELD CENTER ,NHMRC| Uncoupled Research Fellowship ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NIH| Limited Competition:Continuation of the Center for Genomic Studies on Mental Disorders (U24) ,NHMRC| Accurate prediction of individual risk to disease from genome-wide association studies ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NIH| Genome-wide Association in Families: Data Integrity, Design and Methods Issue ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS ,NWO| A social component of the TRIAL study (a prospective longitudinal study of mental health and social development from pre-puberty into young adulthood) with the development of pro- and antisocial behavior over time ,EC| RISKYCAD ,WT| Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians. ,NHMRC| Research Fellowship - Grant ID:442915 ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,EC| SEPI ,NHMRC| Genome-wide combined linkage-association scan of multiply phenotyped twin sibships ,NIH| Genetic Markers of CHD in Type 2 Diabetes ,EC| GEFOS ,NWO| Social and psychopathological developments during adolescence: The assessment of mental disorders and contextually rated life events in the large TRAILS cohort ,NHMRC| Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms ,SNSF| Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population ,NHMRC| Genetics of melanoma risk factors ,SNSF| Studia Ietina VI Das Peristylhaus I von Iaitas: Architektur und Baugeschichte ,NWO| Gender differences in pathways to depression: the interplay of genes, environment, and (endo)phenotype ,NWO| Cluster computing in genetic linkage studies on human complex traits ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,EC| ENGAGE ,SNSF| Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey ,ARC| Maximising knowledge from dense SNP (single nucleotide polymorphisms) data using multi-locus analysis ,WT| Genetic investigation of life course phenotypes of mental health and illness in the 1946 British birth cohort ,NIH| Genome Wide Association Coordinating Center ,NIH| FIELD CENTER FOR CCSP ,NIH| JH/CIDR Genotyping for Genome-Wide Association Studies ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| CENTRAL HEMOSTATIS LABORATORY FOR CCSP ,NHMRC| Better Methods for Individual Risk Prediction of Complex Traits in Human Populations ,NIH| Genetic Influences on ADHD in a Finnish Birth Cohort ,NIH| Genetic analysis of type II diabetes in Finnish populati ,NHMRC| Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families ,NIH| VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION ,NIH| Genetics of cardiovascular risk factors in large founder population birth control ,NIH| Womens Health Study: Continued Follow-Up ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITYStefan Enroth; Nancy Heard-Costa; Jeanette Erdmann; J. Wouter Jukema; Mika Kivimaki; Ines Barroso; Jari Lahti; ZHEN WU; Carlo Rivolta; Jaana Lindström; John D. Rioux; Oluf Pedersen; Mika Kähönen; Paul Franks; Thomas Quertermous; Linda Broer; Folkert Wouter Asselbergs; Kevin Jacobs; Anjali Henders; Ronald Stolk; Liesbeth Vandenput; Tove Fall; Mark McCarthy; Albert Vernon Smith; Grant Montgomery; Wolfgang Koenig; Aroon Hingorani; massimo mangino; Richard Bergman; Gonneke Willemsen; Marcus Richards; Markus Juonala; Lindsay Jones; Federica Rizzi; Uwe Völker; Claire Bellis; Igor Rudan; Amelie Bonnefond; ELENA TREMOLI; Sander W. van der Laan; Lavinia Paternoster; Martina Müller-Nurasyid; Treva Rice; Hester den Ruijter; Claes Ohlsson; Torben Jørgensen; Meena Kumari; Nikolaj Thure Krarup; Aarno Palotie; Patrik Magnusson; Alena Yaluri; Louis Perusse; Hugh Watkins; Alan Shuldiner; Lisette de Groot; Philippe Froguel; Andrew Hicks; Tune Pers; Angela Silveira; Lude Franke; Gemma Cadby; Allan Linneberg; L. Adrienne Cupples; Serena Sanna; Gerard Waeber; Satu Männistö; Andrew Wong; Cristina Barlassina; Marie-Claude Vohl; Nathalie van der Velde; Bruna Gigante; Niels Grarup; Veronique Vitart; Jian Yang; Lambertus Kiemeney; Carolina Medina-Gomez; Anuj Goel; Stavroula Kanoni; Nita Forouhi; Karina Banasik; Sylvain Sebert; Tuomas Kilpeläinen; Juha Sinisalo; Johan Eriksson; Valgerdur Steinthorsdottir; Kalliope Panoutsopoulou; Ruth Loos; Braxton Mitchell; Jan A. Staessen; James Pankow; Panos Deloukas; Christian Gieger; Pirro Hysi; mads melbye; Jennie Hui; Ozren Polasek; Vasiliki Lagou; Annette Peters; Chiara Lanzani; Cornelia Van Duijn; Matteo Barcella; Sita Vermeulen; Leena Kinnunen; John Beilby; Heikki Koistinen; Theodosios Kyriakou; Loic Yengo; Francesco CUCCA; Åsa Johansson; Andrew Hattersley; Karin Leander; Cristina Menni; Pieternella Slagboom; Anubha Mahajan; Jacques S Beckmann; Heather Boyd; Eco de Geus; Lyle John Palmer; Rona Strawbridge; John Blangero; Michael Stumvoll; Reedik Mägi; Stella Trompet; Morris Swertz; Niek Verweij; Natasja van Schoor; Fabrice Bonnet; Robert Luben; Torben Hansen; Eleftheria Zeggini; William Scott; Rick Jansen; Irene Pichler; Mattias Lorentzon; Charleston Chiang; Ivana Kolcic; Marcus Kleber; Claude Bouchard; Mary Feitosa; Claudia Langenberg; Cecilia Lindgren; Inga Prokopenko; Michael Neinast; Peter P Pramstaller; Ayse Demirkan; Jana van Vliet-Ostaptchouk; Damiano Baldassarre; Alexander Teumer; Frank Geller; Peter Kovacs; Timo Lakka; Lili Milani; Vilmundur Gudnason; Anne Justice; Terho Lehtimäki; André G Uitterlinden;Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
PLoS Genetics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pgen.1005378&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu573 citations 573 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert PLoS Genetics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pgen.1005378&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020Cold Spring Harbor Laboratory ARC | Discovery Early Career Re..., ARC | Discovery Projects - Gran...ARC| Discovery Early Career Researcher Award - Grant ID: DE170100310 ,ARC| Discovery Projects - Grant ID: DP180101762Xiyang Dong; Jayne E. Rattray; D. Calvin Campbell; Jamie Webb; Anirban Chakraborty; Oyeboade Adebayo; Stuart Matthews; Carmen Li; Martin Fowler; Adam Macdonald; Ryan A. Groves; Ian A. Lewis; Scott H. Wang; Daisuke Mayumi; Chris Greening; Casey R. J. Hubert;AbstractAt marine cold seeps, gaseous and liquid hydrocarbons migrate from deep subsurface origins to the sediment-water interface. Cold seep sediments are known to host taxonomically diverse microorganisms, but little is known about their metabolic potential and depth distribution in relation to hydrocarbon and electron acceptor availability. In this work, we combined geochemical, metagenomic and metabolomic measurements in distinct sediment redox regimes to profile microbial activities within the uppermost 350 cm of a newly discovered cold seep in the NW Atlantic deep sea (2.3 km water depth). Depth-resolved metagenomic profiling revealed compositional and functional differentiation between near-surface sediments (dominated by Proteobacteria) and deeper subsurface layers (dominated by Atribacteria, Chloroflexi, Euryarchaeota and Lokiarchaeota). Metabolic capabilities of community members were inferred from 376 metagenome-assembled genomes spanning 46 phyla (including five novel candidate phyla). In deeper sulfate-reducing and methanogenic sediments, various community members are capable of anaerobically oxidizing short-chain alkanes (alkyl-CoM reductase pathway), longer-chain alkanes (fumarate addition pathway), and aromatic hydrocarbons (fumarate addition and subsequent benzoyl-CoA pathways). Geochemical profiling demonstrated that hydrocarbon substrates are abundant in this location, thermogenic in origin, and subject to biodegradation. The detection of alkyl-/arylalkylsuccinate metabolites, together with carbon isotopic signatures of ethane, propane and carbon dioxide, support that microorganisms are actively degrading hydrocarbons in these sediments. Hydrocarbon oxidation pathways operate alongside other deep seabed metabolisms such as sulfide oxidation, hydrogen oxidation, carbon fixation, fermentation and reductive dehalogenation. Upward migrated thermogenic hydrocarbons thus sustain diverse microbial communities with activities that affect subseafloor biogeochemical processes across the redox spectrum in deep sea cold seeps.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.02.02.928283&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.02.02.928283&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2019Cold Spring Harbor Laboratory ARC | ARC Future Fellowships - ...ARC| ARC Future Fellowships - Grant ID: FT180100154Fredrik Jutfelt; Dominique G. Roche; Timothy Clark; Tommy Norin; Sandra A. Binning; Ben Speers-Roesch; Mirjam Amcoff; Rachael Morgan; Anna H. Andreassen; Josefin Sundin;doi: 10.1101/658062
ABSTRACTThe physiological mechanisms determining thermal limits in fishes are debated but remain elusive. It has been hypothesised that loss of motor function observed as a loss of equilibrium during an acute thermal challenge is due to direct thermal effects on brain neuronal function. To test this hypothesis, we mounted cooling plates on the head of Atlantic cod(Gadus morhua)and quantified whether local cooling of the brain increased whole-organism critical thermal maxima (CTmax). Brain cooling reduced brain temperature by 2–6°C and increased CTmaxby 0.5–0.7°C relative to instrumented and uninstrumented controls, suggesting that direct thermal effects on brain neurons might contribute to setting upper thermal limits in fish. However, the improvement in CTmaxwith brain cooling was small relative to the difference in brain temperature, demonstrating that other mechanisms (e.g., failure of spinal and peripheral neurons, or muscle) may also contribute to controlling acute thermal tolerance in fishes.Summary statementWe tested whether brain temperature sets the upper thermal limit in a fish. Selectively cooling the brain during whole-organism thermal ramping marginally increased thermal tolerance.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/658062&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/658062&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Preprint , Article 2019Cold Spring Harbor Laboratory ARC | Discovery Projects - Gran...ARC| Discovery Projects - Grant ID: DP150101649Stephen D. J. Archer; Kevin Lee; Tancredi Caruso; Katie King-Miaow; Mike Harvey; Danwei Huang; Benjamin J. Wainwright; Stephen B. Pointing;Abstract The atmosphere is the least understood biome on Earth despite its critical role as a microbial transport medium. The influence of surface cover on composition of airborne microbial communities above marine systems is unclear. Here we report evidence for a dynamic microbial presence at the ocean–atmosphere interface of a major marine ecosystem, the Great Barrier Reef, and identify that recent air mass trajectory over an oceanic or continental surface associated with observed shifts in airborne bacterial and fungal diversity. Relative abundance of shared taxa between air and coral microbiomes varied between 2.2 and 8.8% and included those identified as part of the core coral microbiome. We propose that this variable source of atmospheric inputs may in part contribute to the diverse and transient nature of the coral microbiome.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/583427&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu31 citations 31 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/583427&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2023Cold Spring Harbor Laboratory CIHR, ARC | Molecular genetic analyse..., ARC | Genomics of temperature r... +2 projectsCIHR ,ARC| Molecular genetic analyses of trinucleotide repeat expansions ,ARC| Genomics of temperature response in plants ,ARC| Discovery Projects - Grant ID: DP190101818 ,ARC| ARC Future Fellowships - Grant ID: FT190100403Sridevi Sureshkumar; Champa Bandaranayake; Junqing Lu; Craig I Dent; Chhaya Atri; Harrison M York; Prashanth Tamizhselvan; Nawar Shamaya; Giulia Folini; Prakash Kumar Bhagat; Benjamin G Bergey; Avilash Singh Yadav; Subhasree Kumar; Oliver Grummisch; Prince Saini; Ram K Yadav; Senthil Arumugam; Emanuel Rosonina; Ari Sadanandom; Hongtao Liu; Sureshkumar Balasubramanian;Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich’s ataxia in humans1. The molecular mechanisms underlying repeat expansion-induced epigenetic silencing remain largely unknown2,3. Using a plant model, we have previously shown that expanded repeats can induce smallRNAs which in turn can lead to epigenetic silencing through the RNA-dependent DNA methylation pathway4,5. Here, using a genetic suppressor screen, we confirm a key role for the RdDM pathway and identify novel components required for epigenetic silencing caused by expanded repeats. We show that FOURTH ULP LIKE GENE CLASS 1 (FUG1) – a SUMO protease, ALFIN-LIKE 3 – a histone reader and LIKE HETEROCHROMATIN 1 (LHP1) - a component of the PRC1 complex are required for repeat expansion-induced epigenetic silencing. Loss of any of these components suppress repeat expansion-associated phenotypes. SUMO protease FUG1 physically interacts with AL3 and perturbing its potential SUMOylation site disrupts its nuclear localisation. AL3 physically interacts with LHP1 of the PRC1 complex and the FUG1-AL3-LHP1 module is essential to confer repeat expansion-associated epigenetic silencing. Our findings highlight the importance post-translational modifiers and histone readers in epigenetic silencing caused by repeat expansions.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.01.13.523841&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Germany, Ireland, United Kingdom, Netherlands, Italy, Spain, United Kingdom, France, France, France, United Kingdom, France, France, France, United Kingdom, United Kingdom, France, IrelandSpringer Science and Business Media LLC EC | NEUROSCHEMA, NIH | The ARIC and Neurocogniti..., NIH | Functional genomics of bi... +110 projectsEC| NEUROSCHEMA ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| Functional genomics of bipolar disorder ,NIH| OBESITY, DIABETES &AGING ANIMAL RESOURCE ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NHMRC| Cerebrovascular diseases and Brain Ageing – a program of research into novel mechanisms, risk prevention and innovative health care delivery ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NIH| UCLA Clinical and Translational Science Institute ,NIH| HARDI Mapping of Disease Effects on the Brain ,NIH| Predicting Brain Changes in HIV/AIDS ,NSF| MRI: Acquisition of a Data Analytics Cluster for Computational Social Science ,NIH| CHS-Transition Phase -268055222 ,NIH| Searching for Endophenotypes of Bipolar Disorder ,NIH| Alzheimer's Disease Genetics Consortium ,EC| ORACLE ,NWO| Twin-family database for behavior genetics and genomics studies ,NWO| Networking through ADHD biology ,NIH| Alzheimer's Disease Genetics Consortium ,NIH| Empowering Personalized Medicine: Integrating Imaging, Genetics, and Biomarkers ,FWF| Mechanisms of Small Vessel Related Brain Damage and Cognitive Impairment ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,EC| TACTICS ,WT| Stratifying Resilience and Depression Longitudinally (STRADL) ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Genetic Epidemiology of Cognitive Decline in an Aging Population Sample ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NIH| Occult Small Vessel Cerebrovascular Disease in High Risk Families ,NHMRC| Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,EC| EU-AIMS ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,EC| MATRICS ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NIH| GCRC-RENOVATION ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| International Multi-Center ADHD Genetics Project ,NHMRC| A population-based study of cerebrovascular mechanisms underyling gait, balance and cognition in older people ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,EC| PHASE ,NIH| Hormonal trajectories in aging ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults ,CIHR ,NHMRC| Genetics of brain structure and function ,NIH| Epidemiology of Biomarkers of Risk and Progression in LOAD ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,NHMRC| Australian Twin Registry ,NWO| NCHA Subsidiebesluit 2008-2012 ,ARC| The articulate brain ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Genomic Studies of Bipolar Disorder in a Large Cohort from The Netherlands ,NWO| Neuro-imaging study in twins concordant or discordant for obsessive-compulsive symptoms. ,NIH| ALZHEIMERS DISEASE DATA COORDINATING CENTER ,NHMRC| Genetics of melanoma risk factors ,NIH| Structural Brain Abnormalities In Depression ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,NIH| Alzheimer's disease risk analyzed using population imaging genomics ,NHMRC| Prevention and management of mental disorders in older Australians ,NIH| Functional Neuroimaging In Unipolar And Bipolar Depresse ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,NHMRC| Development and Evaluation of Statistical Methods and Software for Analysis of Complex Genetic Disease Data ,NIH| CHS research resources for the cardiovascular health of older adults ,WT| A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease ,NHMRC| Genetic Repositories Australia ,NIH| Genetic Influences on Human Cortical Development ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,ARC| Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| Vascular Cognitive and Motor Decline: Impact of aPL ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,EC| ENGAGE ,NIH| Genetic influences on the brain: A twin imaging study ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,EC| AGGRESSOTYPE ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION ,NIH| Genetic Influences on Human Neuroanatomical Shapes ,NIH| Neurodevelopment and Imaging among HIV-infected Children from the PREDICT study ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY ,NIH| Alzheimers Disease in Mild Cognitive Impairment ,EC| GMI ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| CORONARY HEART DISEASE AND STROKEHieab H.H. Adams; Vincent Chouraki; Jason L. Stein; Miguel E. Rentería; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Sven J. van der Lee; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Owen Carmichael; Ganesh Chauhan; Qiang Chen; Gabriel Cuellar-Partida; Anouk den Braber; Stefan Ehrlich; Irina Filippi; Tian Ge; Rebecca F. Gottesman; Corina U. Greven; Tulio Guadalupe; Unn K. Haukvik; Saima Hilal; D. Hoehn; Tianye Jia; Marieke Klein; Phil H. Lee; David C. Liewald; Lorna M. Lopez; Michelle Luciano; Christine Macare; Andre F. Marquand; Karen A. Mather; Manuel Mattheisen; Bernard Mazoyer; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L. Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Loes M. Olde Loohuis; Jaap Oosterlaan; Irene Pappa; Lukas Pirpamer; Sara Pudas; Adaikalavan Ramasamy; Jennifer S. Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Jean Shin; Albert V. Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutiérrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen van der Grond; Dennis van der Meer; Marjolein M. J. Van Donkelaar; Kristel R. van Eijk; Theo G.M. van Erp; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Ingrid Agartz; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Mark E. Bastin; Diane M. Becker; James T. Becker; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Randy L. Buckner; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Gareth E. Davies; Eco J. C. de Geus; Greig I. Zubicaray; Anita L. DeStefano; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A. Evans; Iryna O. Fedko; Simon E. Fisher; Debra A. Fleischman; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Harald H H Göring; Hans J. Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Ryota Hashimoto; Andreas Heinz; Stephanie Le Hellard; Dirk J. Heslenfeld; Beng-Choon Ho; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Hilleke E. Hulshoff Pol; M. Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; David S. Knopman; Peter Kochunov; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; W.T. Longstreth; Oscar L. Lopez; Simon Lovestone; Jean-Luc Martinot; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Derek W. Morris; Thomas H. Mosley; Thomas W. Mühleisen; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Roel A. Ophoff; Massimo Pandolfo; G. Bruce Pike; Bruce M. Psaty; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Andrew Singleton; Hilkka Soininen; Velandai Srikanth; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W. Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Aad van der Lugt; Nic J A van der Wee; Cornelia M. van Duijn; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W. Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; H. Ronald Zielke; Alan B. Zonderman; Ian J. Deary; Nicholas G. Martin; Anton J. M. de Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Barbara Franke; Stéphanie Debette; Sarah E. Medland; Paul M. Thompson;pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rhogenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. Contains fulltext : 165723pub.pdf (Publisher’s version ) (Closed access)
CORE (RIOXX-UK Aggre... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2016Data sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016License: Springer TDMNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nn.4398&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu198 citations 198 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 141visibility views 141 download downloads 458 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2016Data sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016License: Springer TDMNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2017Cold Spring Harbor Laboratory NSF | EID: Collaborative Resear..., ARC | What drives parasite spre..., ARC | Discovery Early Career Re...NSF| EID: Collaborative Research: Invasion and Infection: Translocation and Transmission: An Experimental Study with Mycoplasma in Desert Tortoises ,ARC| What drives parasite spread through social networks: lessons from lizards ,ARC| Discovery Early Career Researcher Award - Grant ID: DE170101132Sah, Pratha; Otterstatter, Michael; Leu, Stephan T.; Leviyang, Sivan; Bansal, Shweta;doi: 10.1101/169573
AbstractThe spread of pathogens fundamentally depends on the underlying contacts between individuals. Modeling infectious disease dynamics through contact networks is sometimes challenging, however, due to a limited understanding of pathogen transmission routes and infectivity. We developed a novel tool, INoDS (Identifying Network models of infectious Disease Spread) that estimates the predictive power of empirical contact networks to explain observed patterns of infectious disease spread. We show that our method is robust to partially sampled contact networks, incomplete disease information, and enables hypothesis testing on transmission mechanisms. We demonstrate the applicability of our method in two host-pathogen systems: Crithidia bombi in bumble bee colonies and Salmonella in wild Australian sleepy lizard populations. The performance of INoDS in synthetic and complex empirical systems highlights its role in identifying transmission pathways of novel or neglected pathogens, as an alternative approach to laboratory transmission experiments, and overcoming common data-collection constraints.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/169573&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Spain, DenmarkeLife Sciences Publications, Ltd EC | EPICS, ARC | Composition, assembly and..., WTEC| EPICS ,ARC| Composition, assembly and functions of the pellicle of apicomplexan parasites: a structure pivotal to disease transmission and progression ,WTYong H. Woo; Hifzur Rahman Ansari; Thomas D. Otto; Christen M. Klinger; Martin Kolisko; Jan Michálek; Alka Saxena; Dhanasekaran Shanmugam; Annageldi Tayyrov; Alaguraj Veluchamy; Shahjahan Ali; Axel Bernal; Javier del Campo; Jaromír Cihlář; Pavel Flegontov; Sebastian G. Gornik; Eva Hajdušková; Aleš Horák; Jan Janouškovec; Nicholas J. Katris; Fred D. Mast; Diego Miranda-Saavedra; Tobias Mourier; Raeece Naeem; Mridul Nair; Aswini K. Panigrahi; Neil D. Rawlings; Eriko Padron-Regalado; Abhinay Ramaprasad; Nadira Binte Samad; Aleš Tomčala; Jon Wilkes; Daniel E. Neafsey; Christian Doerig; Chris Bowler; Patrick J. Keeling; David S. Roos; Joel B. Dacks; Thomas J. Templeton; Ross F. Waller; Julius Lukeš; Miroslav Oborník; Arnab Pain;doi: 10.7554/elife.06974
handle: 10069/35779 , 10261/133321
The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. King Abdullah University of Science and Technology (KAUST; Council of Scientific and Industrial Research; National Institute of Allergy and Infectious Diseases (NIAID); Australian Research Council (ARC); Monash University; National Health and Medical Research Council (NHMRC); Czech Science Foundation (Grantova´ agentura Ceske´ republiky) Peer Reviewed
eLife arrow_drop_down Copenhagen University Research Information SystemArticle . 2015Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015https://doi.org/10.7554/eLife....Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.06974&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu215 citations 215 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 22visibility views 22 download downloads 36 Powered bymore_vert eLife arrow_drop_down Copenhagen University Research Information SystemArticle . 2015Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015https://doi.org/10.7554/eLife....Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.06974&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 WT | A national DNA control se..., NIH | Genetics of Early Onset-S..., NIH | Integration of Genomics &... +99 projectsWT| A national DNA control series for genetic case-control studies based on the British 1958 birth cohort ,NIH| Genetics of Early Onset-Stroke ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| Pharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) Study ,NIH| Molecular Genetics of Schizophrenia ,NIH| CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| Whole Genome Assoc. Analysis Strategies for Multi. Phenotypes ,WT| Genetic studies of the aetiology of human metabolic disease: morbid obesity, obesity, severe insulin resistance and type 2 diabetes. ,NIH| ATN 004: HEALTHY CHOICES: MOTIVATIONAL ENHANCEMENT TO PROMOTE HEALTH AND REDU ,NHMRC| Mapping Genes for typical migraine using twin families. ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| Genetic epidemiology of rare and regulatory variants for metabolic traits ,NIH| A Genome-wide Association Study for Early-Onset Myocardial Infarction ,ARC| Why is most of the genetic variance for complex traits undetected by large powerful screens of common variants? ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NHMRC| Explaining the Dark Matter of Genome-wide Association Studies for Complex Disease ,NIH| Genome-wide Association Study of Schizophrenia ,NIH| Molecular Genetics of Schizophrenia ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,EC| ATHEROREMO ,EC| HYPERGENES ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Pharmacogenomics of CVD risk Reduction ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| Delineating risk factors for the initiation and maintenance of cannabis use, in comparison with tobacco use, in adolescence ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| UCLA Clinical and Translational Science Institute ,EC| EPI-MIGRANT ,EC| COPACETIC ,NIH| OSTEOARTHRITIS OF THE KNEE AND HIP IN JOHNSON COUNTY ,NIH| Type 1 Diabetes Genetics Consortium ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| CCSP - FIELD CENTER AND ULTRASOUND READING CENTER ,NIH| TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN ,EC| EURHEALTHAGEING ,WT| The genetics of weight, BMI, adiposity and obesity ,NHMRC| Investigating the role of pigmentation pathway genes in moliness and melanoma risk ,EC| GMI ,EC| EPLORE ,NIH| Identifying Genes for Type 2 Diabetes: FUSION ,NIH| AN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORK ,NIH| Genetic Architecture of Adiposity in Multiple Large Cohorts ,NWO| Tracking Emerging Adults, the fifth wave of the TRAILS study ,NIH| Data Mgmt &Analysis Core - The NINDS International Stroke Genetics Consortium St ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NHMRC| Genetics of melanoma risk factors ,NIH| COMMUNITY AND COHORT SURVEILLANCE PROGRAMS ,NIH| Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,WT| Whole genome strategies for detecting and characterizing complex trait loci. ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,NIH| CCSP-FIELD CENTER ,NHMRC| Uncoupled Research Fellowship ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NIH| Limited Competition:Continuation of the Center for Genomic Studies on Mental Disorders (U24) ,NHMRC| Accurate prediction of individual risk to disease from genome-wide association studies ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NIH| Genome-wide Association in Families: Data Integrity, Design and Methods Issue ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS ,NWO| A social component of the TRIAL study (a prospective longitudinal study of mental health and social development from pre-puberty into young adulthood) with the development of pro- and antisocial behavior over time ,EC| RISKYCAD ,WT| Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians. ,NHMRC| Research Fellowship - Grant ID:442915 ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,EC| SEPI ,NHMRC| Genome-wide combined linkage-association scan of multiply phenotyped twin sibships ,NIH| Genetic Markers of CHD in Type 2 Diabetes ,EC| GEFOS ,NWO| Social and psychopathological developments during adolescence: The assessment of mental disorders and contextually rated life events in the large TRAILS cohort ,NHMRC| Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms ,SNSF| Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population ,NHMRC| Genetics of melanoma risk factors ,SNSF| Studia Ietina VI Das Peristylhaus I von Iaitas: Architektur und Baugeschichte ,NWO| Gender differences in pathways to depression: the interplay of genes, environment, and (endo)phenotype ,NWO| Cluster computing in genetic linkage studies on human complex traits ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,EC| ENGAGE ,SNSF| Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey ,ARC| Maximising knowledge from dense SNP (single nucleotide polymorphisms) data using multi-locus analysis ,WT| Genetic investigation of life course phenotypes of mental health and illness in the 1946 British birth cohort ,NIH| Genome Wide Association Coordinating Center ,NIH| FIELD CENTER FOR CCSP ,NIH| JH/CIDR Genotyping for Genome-Wide Association Studies ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| CENTRAL HEMOSTATIS LABORATORY FOR CCSP ,NHMRC| Better Methods for Individual Risk Prediction of Complex Traits in Human Populations ,NIH| Genetic Influences on ADHD in a Finnish Birth Cohort ,NIH| Genetic analysis of type II diabetes in Finnish populati ,NHMRC| Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families ,NIH| VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION ,NIH| Genetics of cardiovascular risk factors in large founder population birth control ,NIH| Womens Health Study: Continued Follow-Up ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITYStefan Enroth; Nancy Heard-Costa; Jeanette Erdmann; J. Wouter Jukema; Mika Kivimaki; Ines Barroso; Jari Lahti; ZHEN WU; Carlo Rivolta; Jaana Lindström; John D. Rioux; Oluf Pedersen; Mika Kähönen; Paul Franks; Thomas Quertermous; Linda Broer; Folkert Wouter Asselbergs; Kevin Jacobs; Anjali Henders; Ronald Stolk; Liesbeth Vandenput; Tove Fall; Mark McCarthy; Albert Vernon Smith; Grant Montgomery; Wolfgang Koenig; Aroon Hingorani; massimo mangino; Richard Bergman; Gonneke Willemsen; Marcus Richards; Markus Juonala; Lindsay Jones; Federica Rizzi; Uwe Völker; Claire Bellis; Igor Rudan; Amelie Bonnefond; ELENA TREMOLI; Sander W. van der Laan; Lavinia Paternoster; Martina Müller-Nurasyid; Treva Rice; Hester den Ruijter; Claes Ohlsson; Torben Jørgensen; Meena Kumari; Nikolaj Thure Krarup; Aarno Palotie; Patrik Magnusson; Alena Yaluri; Louis Perusse; Hugh Watkins; Alan Shuldiner; Lisette de Groot; Philippe Froguel; Andrew Hicks; Tune Pers; Angela Silveira; Lude Franke; Gemma Cadby; Allan Linneberg; L. Adrienne Cupples; Serena Sanna; Gerard Waeber; Satu Männistö; Andrew Wong; Cristina Barlassina; Marie-Claude Vohl; Nathalie van der Velde; Bruna Gigante; Niels Grarup; Veronique Vitart; Jian Yang; Lambertus Kiemeney; Carolina Medina-Gomez; Anuj Goel; Stavroula Kanoni; Nita Forouhi; Karina Banasik; Sylvain Sebert; Tuomas Kilpeläinen; Juha Sinisalo; Johan Eriksson; Valgerdur Steinthorsdottir; Kalliope Panoutsopoulou; Ruth Loos; Braxton Mitchell; Jan A. Staessen; James Pankow; Panos Deloukas; Christian Gieger; Pirro Hysi; mads melbye; Jennie Hui; Ozren Polasek; Vasiliki Lagou; Annette Peters; Chiara Lanzani; Cornelia Van Duijn; Matteo Barcella; Sita Vermeulen; Leena Kinnunen; John Beilby; Heikki Koistinen; Theodosios Kyriakou; Loic Yengo; Francesco CUCCA; Åsa Johansson; Andrew Hattersley; Karin Leander; Cristina Menni; Pieternella Slagboom; Anubha Mahajan; Jacques S Beckmann; Heather Boyd; Eco de Geus; Lyle John Palmer; Rona Strawbridge; John Blangero; Michael Stumvoll; Reedik Mägi; Stella Trompet; Morris Swertz; Niek Verweij; Natasja van Schoor; Fabrice Bonnet; Robert Luben; Torben Hansen; Eleftheria Zeggini; William Scott; Rick Jansen; Irene Pichler; Mattias Lorentzon; Charleston Chiang; Ivana Kolcic; Marcus Kleber; Claude Bouchard; Mary Feitosa; Claudia Langenberg; Cecilia Lindgren; Inga Prokopenko; Michael Neinast; Peter P Pramstaller; Ayse Demirkan; Jana van Vliet-Ostaptchouk; Damiano Baldassarre; Alexander Teumer; Frank Geller; Peter Kovacs; Timo Lakka; Lili Milani; Vilmundur Gudnason; Anne Justice; Terho Lehtimäki; André G Uitterlinden;Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
PLoS Genetics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu573 citations 573 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert PLoS Genetics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020Cold Spring Harbor Laboratory ARC | Discovery Early Career Re..., ARC | Discovery Projects - Gran...ARC| Discovery Early Career Researcher Award - Grant ID: DE170100310 ,ARC| Discovery Projects - Grant ID: DP180101762Xiyang Dong; Jayne E. Rattray; D. Calvin Campbell; Jamie Webb; Anirban Chakraborty; Oyeboade Adebayo; Stuart Matthews; Carmen Li; Martin Fowler; Adam Macdonald; Ryan A. Groves; Ian A. Lewis; Scott H. Wang; Daisuke Mayumi; Chris Greening; Casey R. J. Hubert;AbstractAt marine cold seeps, gaseous and liquid hydrocarbons migrate from deep subsurface origins to the sediment-water interface. Cold seep sediments are known to host taxonomically diverse microorganisms, but little is known about their metabolic potential and depth distribution in relation to hydrocarbon and electron acceptor availability. In this work, we combined geochemical, metagenomic and metabolomic measurements in distinct sediment redox regimes to profile microbial activities within the uppermost 350 cm of a newly discovered cold seep in the NW Atlantic deep sea (2.3 km water depth). Depth-resolved metagenomic profiling revealed compositional and functional differentiation between near-surface sediments (dominated by Proteobacteria) and deeper subsurface layers (dominated by Atribacteria, Chloroflexi, Euryarchaeota and Lokiarchaeota). Metabolic capabilities of community members were inferred from 376 metagenome-assembled genomes spanning 46 phyla (including five novel candidate phyla). In deeper sulfate-reducing and methanogenic sediments, various community members are capable of anaerobically oxidizing short-chain alkanes (alkyl-CoM reductase pathway), longer-chain alkanes (fumarate addition pathway), and aromatic hydrocarbons (fumarate addition and subsequent benzoyl-CoA pathways). Geochemical profiling demonstrated that hydrocarbon substrates are abundant in this location, thermogenic in origin, and subject to biodegradation. The detection of alkyl-/arylalkylsuccinate metabolites, together with carbon isotopic signatures of ethane, propane and carbon dioxide, support that microorganisms are actively degrading hydrocarbons in these sediments. Hydrocarbon oxidation pathways operate alongside other deep seabed metabolisms such as sulfide oxidation, hydrogen oxidation, carbon fixation, fermentation and reductive dehalogenation. Upward migrated thermogenic hydrocarbons thus sustain diverse microbial communities with activities that affect subseafloor biogeochemical processes across the redox spectrum in deep sea cold seeps.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.02.02.928283&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2019Cold Spring Harbor Laboratory ARC | ARC Future Fellowships - ...ARC| ARC Future Fellowships - Grant ID: FT180100154Fredrik Jutfelt; Dominique G. Roche; Timothy Clark; Tommy Norin; Sandra A. Binning; Ben Speers-Roesch; Mirjam Amcoff; Rachael Morgan; Anna H. Andreassen; Josefin Sundin;doi: 10.1101/658062
ABSTRACTThe physiological mechanisms determining thermal limits in fishes are debated but remain elusive. It has been hypothesised that loss of motor function observed as a loss of equilibrium during an acute thermal challenge is due to direct thermal effects on brain neuronal function. To test this hypothesis, we mounted cooling plates on the head of Atlantic cod(Gadus morhua)and quantified whether local cooling of the brain increased whole-organism critical thermal maxima (CTmax). Brain cooling reduced brain temperature by 2–6°C and increased CTmaxby 0.5–0.7°C relative to instrumented and uninstrumented controls, suggesting that direct thermal effects on brain neurons might contribute to setting upper thermal limits in fish. However, the improvement in CTmaxwith brain cooling was small relative to the difference in brain temperature, demonstrating that other mechanisms (e.g., failure of spinal and peripheral neurons, or muscle) may also contribute to controlling acute thermal tolerance in fishes.Summary statementWe tested whether brain temperature sets the upper thermal limit in a fish. Selectively cooling the brain during whole-organism thermal ramping marginally increased thermal tolerance.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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