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A detailed investigation of the magnetic properties of young Sun-like stars can provide valuable information on our Sun's magnetic past and its impact on the early Earth. We determine the properties of the moderately rotating young Sun-like star kappa Ceti's magnetic and activity cycles using 50 years of chromospheric activity data and six epochs of spectropolarimetric observations. The chromospheric activity was determined by measuring the flux in the Ca II H and K lines. A generalised Lomb-Scargle periodogram and a wavelet decomposition were used on the chromospheric activity data to establish the associated periodicities. The vector magnetic field of the star was reconstructed using the technique of Zeeman Doppler imaging on the spectropolarimetric observations. Our period analysis algorithms detect a 3.1 year chromospheric cycle in addition to the star's well-known ~6 year cycle period. Although the two cycle periods have an approximate 1:2 ratio, they exhibit an unusual temporal evolution. Additionally, the spectropolarimetric data analysis shows polarity reversals of the star's large-scale magnetic field, suggesting a ~10 year magnetic or Hale cycle. The unusual evolution of the star's chromospheric cycles and their lack of a direct correlation with the magnetic cycle establishes kappa Ceti as a curious young Sun. Such complex evolution of magnetic activity could be synonymous with moderately active young Suns, which is an evolutionary path that our own Sun could have taken. Comment: 15 pages including appendices, accepted for publication in A&A

Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In structures with low myelin content, such as deep gray matter, R2* shows a linear increase with increasing iron content. In white matter, R2* is not only affected by iron and myelin but also by the orientation of the myelinated axons with respect to the external magnetic field. Here, we propose a numerical model which incorporates iron and myelin, as well as fibre orientation, to simulate R2* decay in white matter. Applying our model to fibre orientation‐dependent in vivo R2* data, we are able to determine a unique solution of myelin and iron content in global white matter. We determine an averaged myelin volume fraction of 16.02 ± 2.07% in non‐lesional white matter of patients with MS, 17.32 ± 2.20% in matched healthy controls, and 18.19 ± 2.98% in healthy siblings of patients with MS. Averaged iron content was 35.6 ± 8.9 mg/kg tissue in patients, 43.1 ± 8.3 mg/kg in controls, and 47.8 ± 8.2 mg/kg in siblings. All differences in iron content between groups were significant, while the difference in myelin content between MS patients and the siblings of MS patients was significant. In conclusion, we demonstrate that a model that combines myelin‐induced orientation‐dependent and iron‐induced orientation‐independent components is able to fit in vivo R2* data.

The segregation of different cell types into distinct tissues is a fundamental process in metazoan development. Differences in cell adhesion and cortex tension are commonly thought to drive cell sorting by regulating tissue surface tension (TST). However, the role that differential TST plays in cell segregation within the developing embryo is as yet unclear. Here, we have analyzed the role of differential TST for germ layer progenitor cell segregation during zebrafish gastrulation. Contrary to previous observations that differential TST drives germ layer progenitor cell segregation in vitro, we show that germ layers display indistinguishable TST within the gastrulating embryo, arguing against differential TST driving germ layer progenitor cell segregation in vivo. We further show that the osmolarity of the interstitial fluid (IF) is an important factor that influences germ layer TST in vivo, and that lower osmolarity of the IF compared with standard cell culture medium can explain why germ layers display differential TST in culture but not in vivo. Finally, we show that directed migration of mesendoderm progenitors is required for germ layer progenitor cell segregation and germ layer formation. Highlighted Article: Segregation of the germ layer progenitors in the zebrafish gastrula is driven by directed cell migration, rather than differential tissue surface tension.

Within the recently introduced auxiliary master equation approach it is possible to address steady state properties of strongly correlated impurity models, small molecules or clusters efficiently and with high accuracy. It is particularly suited for dynamical mean field theory in the nonequilibrium as well as in the equilibrium case. The method is based on the solution of an auxiliary open quantum system, which can be made quickly equivalent to the original impurity problem. In its first implementation a Krylov space method was employed. Here, we aim at extending the capabilities of the approach by adopting matrix product states for the solution of the corresponding auxiliary quantum master equation. This allows for a drastic increase in accuracy and permits us to access the Kondo regime for large values of the interaction. In particular, we investigate the nonequilibrium steady state of a single impurity Anderson model and focus on the spectral properties for temperatures T below the Kondo temperature T_K and for small bias voltages phi. For the two cases considered, with T=T_K/4 and T=T_K/10 we find a clear splitting of the Kondo resonance into a two-peak structure for phi close above T_K. In the equilibrium case (phi=0) and for T=T_K/4, the obtained spectral function essentially coincides with the one from numerical renormalization group. Comment: 11 pages, 10 figures

The effect of induction of protein production was studied in bioreactor cultures of the T. reesei strain Rut-C30 and its transformant expressing endoglucanase I (EGI, Cel7B) fused with a hydrophobic tag. The peptide tag was previously designed for efficient purification of the fusion protein in aqueous two-phase separation. The first phase of the bioreactor cultivations was carried out on glucose containing minimal medium. At the stage when glucose was nearly depleted, the medium was supplemented with rich medium containing lactose as a carbon source to induce production of cellulases. The transformant produced somewhat less secreted protein and cellobiohydrolase I (CBHI, Cel7A) activity than the parental strain. Western analysis of intracellular proteins showed that the fusion protein EGIcore-P5(WP)4 accumulated inside the cell, indicating impaired secretion of the protein. Two-dimensional gel analysis suggested that the fusion protein was possibly trapped early in the secretory pathway. The mRNA levels of the UPR (unfolded protein response) target genes, bip1 and pdil, and the level of the activated hac1 transcript encoding the UPR transcription factor, increased at the same time with an increase in the transcript levels of cellulase genes, suggesting UPR activation in response to cellulase induction. However, only a minor increase in pdi1 and bip1 transcript level was observed in the transformant expressing the fusion protein compared to its parental strain. In addition, slightly lower CBHI production and cbhl mRNA levels were measured in the transformant as compared to the parental strain, indicating activation of the novel repression mechanism of genes encoding secreted proteins in response to secretion stress, RESS (repression under secretion stress).

The dark photon $A^\prime$ and the dark Higgs boson $h^\prime$ are hypothetical particles predicted in many dark sector models. We search for the simultaneous production of $A^\prime$ and $h^\prime$ in the dark Higgsstrahlung process $e^{+}e^{-}\rightarrow A^\prime \, h^\prime$ with $A^\prime \rightarrow \mu^+\mu^-$ and $ h^\prime$ invisible in electron-positron collisions at a center-of-mass energy of 10.58 GeV collected by the Belle II experiment in 2019. With an integrated luminosity of 8.34 fb$^{-1}$ we observe no evidence for signal. We obtain exclusion limits at 90% Bayesian credibility in the range 1.7--5.0 fb on the cross section and in the range $1.7 \times10^{-8}$--$200 \times10^{-8}$ on the effective coupling $\varepsilon^2 \times \alpha_D$, for $A^\prime$ mass 4.0 GeV/$c^2$ $< M_{A^\prime}< 9.7$ GeV/$c^2$ and $h^\prime$ mass $M_{h^\prime} < M_{A^\prime}$, where $\varepsilon$ is the mixing strength between the Standard Model and the dark photon and $\alpha_D$ is the coupling of the dark photon to the dark Higgs boson. Our limits are the first in this mass range. Physical review letters 130(7), 071804 (2023). doi:10.1103/PhysRevLett.130.071804 Published by APS, College Park, Md.

Ultrashort high-energy pulses at wavelengths longer than 1 µm are now desirable for a vast variety of applications in ultrafast and strong-field physics. To date, the main answer to the wavelength tunability for energetic, broadband pulses still relies on optical parametric amplification (OPA), which often requires multiple and complex stages, may feature imperfect beam quality, and has limited conversion efficiency into one of the amplified waves. In this work, we present a completely different strategy to realize an energy-efficient and scalable laser frequency shifter. This relies on the continuous red shift provided by stimulated Raman scattering (SRS) over a long propagation distance in nitrogen-filled hollow-core fibers (HCF). We show a continuous tunability of the laser wavelength from 1030 nm up to 1730 nm with a conversion efficiency higher than 70% and high beam quality. The highly asymmetric spectral broadening, arising from the spatiotemporal nonlinear interplay between higher-order modes of the HCF, can be readily employed to generate pulses ( ∼ 20 f s ) significantly shorter than the pump ones ( ∼ 200 f s ) with high beam quality, and the pulse energy can further be scaled up to tens of millijoules. We envision that this technique, coupled with the emerging high-power Yb laser technology, has the potential to answer the increasing demand for energetic multi-TW few-cycle sources tunable in the near-IR.

This is the first article in a series of two papers in which we study the Temperleyan dimer model on an arbitrary bounded Riemann surface of finite topolgical type. The end goal of both papers is to prove the convergence of height fluctuations to a universal and conformally invariant scaling limit. In this part we show that the dimer model on the Temperleyan superposition of a graph embedded on the surface and its dual is well posed, provided that we remove an appropriate number of punctures. We further show that the resulting dimer configuration is in bijection with an object which we call Temperleyan forest, whose law is characterised in terms of a certain topological condition. Finally we discuss the relation between height differences and Temperleyan forest, and give a criterion guaranteeing the convergence of the height fluctuations in terms of the Temperleyan forest. Comment: v2: 57 pages. The paper was thoroughly updated in coordination with the release of the second article in this series