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description Publicationkeyboard_double_arrow_right Article 2016Ovid Technologies (Wolters Kluwer Health) NIH | Phase 2 Study of Mexileti..., NIH | Novel Molecular Mechanism..., CIHR +24 projectsNIH| Phase 2 Study of Mexiletine for the Treatment of Myotonic Dystrophy ,NIH| Novel Molecular Mechanisms of Neuromuscular Disease: Implications for Therapy ,CIHR ,NIH| BIOEQUIVALENCE AND CLINICAL IMPLICATIONS OF GENERIC BUPROPION ,NIH| IN VIVO NMR METABOLIC STUDY OF REGIONAL CARDIAC ISCHEMIA ,NIH| Evaluation of Treatments and Services to People with Duchenne Muscular Dystrophy ,NIH| BIOLOGY OF THE BONE MARROW DERIVED 3A1 STEM CELL ,NIH| Novel Strategy for Perioperative Beta-Blocker Therapy ,NIH| GENETICS-InFORMATICS TRIAL (GIFT) OF WARFARIN TO PREVENT DVT ,NIH| 9th International Myotonic Dystrophy Consortium Meeting ,NIH| Biiostatistics ,NIH| Disease Progression in Myotonic Dystrophy ,NIH| EXPERIMENTAL THERAPEUTICS IN NEUROLOGICAL DISEASE ,NIH| Comp A-NY State Surveillance and Research of MD and Neuromuscular Disorders ,NIH| BIOENERGETIC MECHANISMS ,NIH| POSITRON EMISSION TOMOGRAPHIC IMAGING OF LUNG TRANSPLANT ,SSHRC ,NIH| Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2 ,NIH| Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise ,NIH| Genetically Informed Smoking Cessation Trial ,NIH| Ocular Hypertension Treatment Study 20-Year Follow-up: Clinical Center Grant ,NIH| RNA-mediated mechanisms in the myotonic dystrophies ,NIH| 7th International Myotonic Dystrophy Consortium Meeting ,NIH| FOR-DMD: Double-blind randomized trial to optimize steroid regimen in Duchenne MD ,NIH| Washington University Institute of Clinical and Translational Sciences ,NIH| Tenth International Myotonic Dystrophy Consortium Meeting ,NIH| ANALYSIS OF THE E COLI STB HEAT STABLE ENTEROTOXINAuthors: Griggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; +11 AuthorsGriggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; Pestronk, Alan; Mendell, Jerry R.; Moxley, Richard T.; King, Wendy; Kissel, John T.; Cwik, Valerie; Vanasse, Michel; Florence, Julaine M.; Pandya, Shree; Dubow, Jordan S.; Meyer, James M.;Objective: To assess safety and efficacy of deflazacort (DFZ) and prednisone (PRED) vs placebo in Duchenne muscular dystrophy (DMD). Methods: This phase III, double-blind, randomized, placebo-controlled, multicenter study evaluated muscle strength among 196 boys aged 5–15 years with DMD during a 52-week period. In phase 1, participants were randomly assigned to receive treatment with DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, PRED 0.75 mg/kg/d, or placebo for 12 weeks. In phase 2, placebo participants were randomly assigned to 1 of the 3 active treatment groups. Participants originally assigned to an active treatment continued that treatment for an additional 40 weeks. The primary efficacy endpoint was average change in muscle strength from baseline to week 12 compared with placebo. The study was completed in 1995. Results: All treatment groups (DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, and PRED 0.75 mg/kg/d) demonstrated significant improvement in muscle strength compared with placebo at 12 weeks. Participants taking PRED had significantly more weight gain than placebo or both doses of DFZ at 12 weeks; at 52 weeks, participants taking PRED had significantly more weight gain than both DFZ doses. The most frequent adverse events in all 3 active treatment arms were Cushingoid appearance, erythema, hirsutism, increased weight, headache, and nasopharyngitis. Conclusions: After 12 weeks of treatment, PRED and both doses of DFZ improved muscle strength compared with placebo. Deflazacort was associated with less weight gain than PRED. Classification of evidence: This study provides Class I evidence that for boys with DMD, daily use of either DFZ and PRED is effective in preserving muscle strength over a 12-week period.
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For further information contact us at helpdesk@openaire.eu115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 0 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 France, Italy, United KingdomAmerican Association for the Advancement of Science (AAAS) SSHRC, EC | LANGELIN, SNSF | 111-Silver labelling of m... +14 projectsSSHRC ,EC| LANGELIN ,SNSF| 111-Silver labelling of monoclonal antibodies to produce selective cytotoxic agents ,NSF| Statistical Methods for Enabling Medical and Population Genomics of Admixed Human Populations ,SNSF| Islamische Diskurse und die soziale Integration von Muslimen in den USA ,NIH| Mathematical Models and Statistical Methods for Large-Scale Population Genomics ,EC| TGOFA ,UKRI| Detecting signatures of natural selection in the human genome with geographically explicit models ,EC| NEOLITHISATION ,ARC| Molecular Archaeology: Carbon isotope analysis of amino acids as a means to investigate diets, physiology, metabolism and palaeoenvironment. ,NSF| Collaborative Research: Anthropological-Genomic Effects of European Colonization on Native North Americans ,SNSF| Using time serial samples to characterize the timing ad strength of selective sweeps ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,WT ,EC| MALADAPTED ,NIH| Human Population Diversity in Leukocyte Receptors ,SNSF| Characterizing migrations with modern and ancient genomic data: the limits of the Polynesian expansionRaghavan, M.; Steinrücken, M; Harris, M; Schiffels, Stephan; DeGiorgio, Michael; Albrechtsen, M; Valdiosera, M; Ávila-Arcos, M; Malaspinas, M; Eriksson, Anders; Moltke, M; Homburger, M; Wall, Jeff; Cornejo, Omar; Moreno-Mayar, M; Korneliussen, M; Pierre, M; Rasmussen, Rasmus; Campos, Paul; de Barros Damgaard, Peter; Allentoft, M.; Lindo, John; Metspalu, M.; Rodríguez-Varela, Carlos; Mansilla, M; Henrickson, Celeste; Seguin-Orlando, M; Malmström, M; Stafford, M; Shringarpure, M; Moreno-Estrada, M; Karmin, M.; Tambets, Kristiina; Bergström, Anders; Xue, Yali; Vera, Vera; Friend, Andrew; Singarayer, M; Valdes, Paul; Balloux, François; Leboreiro, M; Vera, M; Rangel-Villalobos, M; Pettener, David; Luiselli, Donata; Davis, Loren; Heyer, M; Zollikofer, Chris; Ponce de León, M; Smith, M; Grimes, John; Pike, John; Deal, John; Fuller, M; Arriaza, Bernardo; Standen, Vivien; Luz, M.; Ricaut, M; Guidon, M; Osipova, Ludmila; Voevoda, M.; Posukh, Olga; Balanovsky, M; Lavryashina, M.; Bogunov, M; Khusnutdinova, M; Gubina, M.; Balanovska, M; Fedorova, M; Litvinov, Sergey; Malyarchuk, M; Derenko, M.; Mosher, M.; Archer, David; Cybulski, Jerome; Petzelt, Barbara; Mitchell, Joycelynn; Worl, Rosita; Norman, Paul; Parham, Peter; Kemp, Brian,; Kivisild, Toomas; Smith, Chris; Sandhu, Manjinder,; Crawford, Michael; Villems, Richard; Smith, David; Waters, Michael; Goebel, Ted; Johnson, John; Malhi, Ripan; Jakobsson, Mattias; Meltzer, David; Manica, Andrea; Durbin, Richard; Bustamante, Carlos,; Song, Yun; Nielsen, Rasmus; Willerslev, Eske; Steinrucken, M.; Harris, K.; Rasmussen, S.; Albrechtsen, A.; Valdiosera, C.; Avila-Arcos, M.; Malaspinas, S.; Moltke, I.; Homburger, J.; Moreno-Mayar, J.; Korneliussen, S.; Pierre, T.; Rasmussen, M.; Damgaard, P.; Metspalu, E.; Rodriguez-Varela, R.; Mansilla, J.; Seguin-Orlando, A.; Malmstrom, H.; Stafford, T.; Shringarpure, S.; Moreno-Estrada, A.; Bergstrom, A.; Warmuth, V.; Singarayer, J.; Leboreiro, I.; Vera, J.; Rangel-Villalobos, H.; Heyer, E.; Ponce De Leon, M.; Grimes, V.; Pike, K.; Deal, M.; Fuller, T.; Ricaut, F.; Guidon, N.; Balanovsky, O.; Bogunov, Y.; Khusnutdinova, E.; Balanovska, E.; Fedorova, S.; Malyarchuk, B.; Norman, J.; Kemp, M.; Malhi, S.; Meltzer, J.; Song, S.;How and when the Americas were populated remains contentious. Using ancient and modern genome wide data we found that the ancestors of all present day Native Americans including Athabascans and Amerindians entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000 year isolation period in Beringia. After their arrival to the Americas ancestral Native Americans diversified into two basal genetic branches around 13 ka one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present day East Asians (including Siberians) and more distantly Australo Melanesians. Putative “Paleoamerican” relict populations including the historical Mexican Pericúes and South American Fuego Patagonians are not directly related to modern Australo Melanesians as suggested by the Paleoamerican Model. INTRODUCTION The consensus view on the peopling of the Americas is that ancestors of modern Native Americans entered the Americas from Siberia via the Bering Land Bridge and that this occurred at least {\textasciitilde}14.6 thousand years ago (ka). However the number and timing of migrations into the Americas remain controversial with conflicting interpretations based on anatomical and genetic evidence. RATIONALE In this study we address four major unresolved issues regarding the Pleistocene and recent population history of Native Americans: (i) the timing of their divergence from their ancestral group (ii) the number of migrations into the Americas (iii) whether there was {\textasciitilde}15000 years of isolation of ancestral Native Americans in Beringia (Beringian Incubation Model) and (iv) whether there was post Pleistocene survival of relict populations in the Americas related to Australo Melanesians as suggested by apparent differences in cranial morphologies between some early (“Paleoamerican”) remains and those of more recent Native Americans. We generated 31 high coverage modern genomes from the Americas Siberia and Oceania; 23 ancient genomic sequences from the Americas dating between {\textasciitilde}0.2 and 6 ka; and SNP chip genotype data from 79 present day individuals belonging to 28 populations from the Americas and Siberia. The above data sets were analyzed together with published modern and ancient genomic data from worldwide populations after masking some present day Native Americans for recent European admixture. RESULTS Using three different methods we determined the divergence time for all Native Americans (Athabascans and Amerindians) from their Siberian ancestors to be {\textasciitilde}20 ka and no earlier than {\textasciitilde}23 ka. Furthermore we dated the divergence between Athabascans (northern Native American branch together with northern North American Amerindians) and southern North Americans and South and Central Americans (southern Native American branch) to be {\textasciitilde}13 ka. Similar divergence times from East Asian populations and a divergence time between the two branches that is close in age to the earliest well established archaeological sites in the Americas suggest that the split between the branches occurred within the Americas. We additionally found that several sequenced Holocene individuals from the Americas are related to present day populations from the same geographical regions implying genetic continuity of ancient and modern populations in some parts of the Americas over at least the past 8500 years. Moreover our results suggest that there has been gene flow between some Native Americans from both North and South America and groups related to East Asians and Australo Melanesians the latter possibly through an East Asian route that might have included ancestors of modern Aleutian Islanders. Last using both genomic and morphometric analyses we found that historical Native American groups such as the Pericúes and Fuego Patagonians were not “relicts” of Paleoamericans and hence our results do not support an early migration of populations directly related to Australo Melanesians into the Americas. CONCLUSION Our results provide an upper bound of {\textasciitilde}23 ka on the initial divergence of ancestral Native Americans from their East Asian ancestors followed by a short isolation period of no more than {\textasciitilde}8000 years and subsequent entrance and spread across the Americas. The data presented are consistent with a single migration model for all Native Americans with later gene flow from sources related to East Asians and indirectly Australo Melanesians. The single wave diversified {\textasciitilde}13 ka likely within the Americas giving rise to the northern and southern branches of present day Native Americans. View larger version: In this page In a new window Download PowerPoint Slide for Teaching Population history of present day Native Americans.The ancestors of all Native Americans entered the Americas as a single migration wave from Siberia (purple) no earlier than {\textasciitilde}23 ka separate from the Inuit (green) and diversified into “northern” and “southern” Native American branches {\textasciitilde}13 ka. There is evidence of post divergence gene flow between some Native Americans and groups related to East Asians/Inuit and Australo Melanesians (yellow). Genetic history of Native Americans Several theories have been put forth as to the origin and timing of when Native American ancestors entered the Americas. To clarify this controversy Raghavan et al. examined the genomic variation among ancient and modern individuals from Asia and the Americas. There is no evidence for multiple waves of entry or recurrent gene flow with Asians in northern populations. The earliest migrations occurred no earlier than 23000 years ago from Siberian ancestors. Amerindians and Athabascans originated from a single population splitting approximately 13000 years ago. Science this issue 10.1126/science.aab3884
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For further information contact us at helpdesk@openaire.eu407 citations 407 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010 United States, CanadaPublic Library of Science (PLoS) CIHR, SSHRC, NIH | Center for AIDS ResearchCIHR ,SSHRC ,NIH| Center for AIDS ResearchAngela Kaida; Fatima Laher; Steffanie A. Strathdee; Deborah Money; Patricia A. Janssen; Robert S. Hogg; Glenda Gray;Objective Preventing unintended pregnancy among HIV-positive women constitutes a critical and cost-effective approach to primary prevention of mother-to-child transmission of HIV and is a global public health priority for addressing the desperate state of maternal and child health in HIV hyper-endemic settings. We sought to investigate whether the prevalence of contraceptive use and method preferences varied by HIV status and receipt of highly active antiretroviral therapy (HAART) among women in Soweto, South Africa. Methods We used survey data from 563 sexually active, non-pregnant women (18–44 years) recruited from the Perinatal HIV Research Unit in Soweto (May–December, 2007); 171 women were HIV-positive and receiving HAART (median duration of use = 31 months; IQR = 28, 33), 178 were HIV-positive and HAART-naive, and 214 were HIV-negative. Medical record review was conducted to confirm HIV status and clinical variables. Logistic regression models estimated adjusted associations between HIV status, receipt of HAART, and contraceptive use. Results Overall, 78% of women reported using contraception, with significant variation by HIV status: 86% of HAART users, 82% of HAART-naive women, and 69% of HIV-negative women (p<0.0001). In adjusted models, compared with HIV-negative women, women receiving HAART were significantly more likely to use contraception while HAART-naive women were non-significantly more likely (AOR: 2.40; 95% CI: 1.25, 4.62 and AOR: 1.59; 95% CI: 0.88, 2.85; respectively). Among HIV-positive women, HAART users were non-significantly more likely to use contraception compared with HAART-naive women (AOR: 1.55; 95% CI: 0.84, 2.88). Similar patterns held for specific use of barrier (primarily male condoms), permanent, and dual protection contraceptive methods. Conclusion Among HIV-positive women receiving HAART, the observed higher prevalence of contraceptive use overall and condoms in particular promises to yield fewer unintended pregnancies and reduced risks of vertical and sexual HIV transmission. These findings highlight the potential of integrated HIV and reproductive health services to positively impact maternal, partner, and child health.
Europe PubMed Centra... arrow_drop_down Simon Fraser University Institutional RepositoryArticle . 2010Data sources: Simon Fraser University Institutional RepositoryeScholarship - University of CaliforniaArticle . 2010Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu81 citations 81 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Simon Fraser University Institutional RepositoryArticle . 2010Data sources: Simon Fraser University Institutional RepositoryeScholarship - University of CaliforniaArticle . 2010Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 English NIH | Longitudinal Study of Vag..., SSHRC, NSERC +4 projectsNIH| Longitudinal Study of Vaginal Microbiota and Persistent Human Papillomavirus Detection ,SSHRC ,NSERC ,ANR| CHESS ,NIH| Global Health Equity Scholars Program - D43 Fogarty Training ,AKA| Intra-Genomic Conflicts and Social Decision-Making in Humans ,NIH| Psychological functions of music in infancyMoser, Cody J.; Lee-Rubin, Harry; Bainbridge, Constance M.; Atwood, S.; Simson, Jan; Knox, Dean; Glowacki, Luke; Galbarczyk, Andrzej; Jasienska, Grazyna; Ross, Cody T.; Neff, Mary Beth; Martin, Alia; Cirelli, Laura K.; Trehub, Sandra E.; Song, Jinqi; Kim, Minju; Schachner, Adena; Vardy, Tom A.; Atkinson, Quentin D.; Antfolk, Jan; Madhivanan, Purnima; Siddaiah, Anand; Placek, Caitlyn D.; Salali, Gul Deniz; Keestra, Sarai; Singh, Manvir; Collins, Scott A.; Patton, John Q.; Scaff, Camila; Stieglitz, Jonathan; Moya, Cristina; Sagar, Rohan R.; Wood, Brian M.; Krasnow, Max M.; Mehr, Samuel A.;Abstract Humans often produce vocalizations for infants that differ from vocalizations for adults. Is this property common across societies? The forms of infant-directed vocalizations may be shaped by their function in parent-infant communication. If so, infant-directed song and speech should be differentiable from adult-directed song and speech on the basis of their acoustic features, and this property should be relatively invariant across cultures. To test this hypothesis, we built a corpus of 1,614 recordings of infant- and adult-directed singing and speech produced by 411 people living in 21 urban, rural, and small-scale societies. We studied the corpus in a massive online experiment and in a series of acoustic analyses. Naïve listeners ( N = 13,218) reliably identified infant-directed vocalizations as infant-directed, and adult-directed speech (but not songs) as adult-directed, at rates far higher than chance. Ratings of infant-directed song were the most accurate and the most consistent across all societies; infant-directed speech was accurately identified on average, but inconsistently across societies. To determine the mechanisms underlying these results, we extracted many acoustic features from each recording and identified those that most reliably characterize infant-directed song and speech across cultures, via preregistered exploratory-confirmatory analyses and machine classification. The features distinguishing infant- and adult-directed song and speech concerned pitch, rhythmic, phonetic, and timbral attributes; a hypothesis-free classifier with cross-validation across societies reliably identified all vocalization types, with highest accuracy for infant-directed song. Last, we isolated 12 acoustic features that were predictive of perceived infant-directedness; of these, two pitch attributes (median F0 and its variability) were by far the most explanatory. These findings demonstrate cross-cultural regularities in infant-directed vocalizations that are suggestive of universality; moreover, infant-directed song appears to be more cross-culturally stereotyped than infant-directed speech, informing hypotheses of the functions and evolution of both.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Netherlands, Poland, United StatesSpringer Science and Business Media LLC NSERC, NIH | Longitudinal Study of Vag..., SSHRC +4 projectsNSERC ,NIH| Longitudinal Study of Vaginal Microbiota and Persistent Human Papillomavirus Detection ,SSHRC ,NIH| Psychological functions of music in infancy ,ANR| CHESS ,NIH| Global Health Equity Scholars Program - D43 Fogarty Training ,AKA| Intra-Genomic Conflicts and Social Decision-Making in HumansCourtney B. Hilton; Cody J. Moser; Mila Bertolo; Harry Lee-Rubin; Dorsa Amir; Constance M. Bainbridge; Jan Simson; Dean Knox; Luke Glowacki; Elias Alemu; Andrzej Galbarczyk; Grazyna Jasienska; Cody T. Ross; Mary Beth Neff; Alia Martin; Laura K. Cirelli; Sandra E. Trehub; Jinqi Song; Minju Kim; Adena Schachner; Tom A. Vardy; Quentin D. Atkinson; Amanda Salenius; Jannik Andelin; Jan Antfolk; Purnima Madhivanan; Anand Siddaiah; Caitlyn D. Placek; Gul Deniz Salali; Sarai Keestra; Manvir Singh; Scott A. Collins; John Q. Patton; Camila Scaff; Jonathan Stieglitz; Silvia Ccari Cutipa; Cristina Moya; Rohan R. Sagar; Mariamu Anyawire; Audax Mabulla; Brian M. Wood; Max M. Krasnow; Samuel A. Mehr;National audience; When interacting with infants, humans often alter their speech and song in ways thought to support communication. Theories of human child-rearing, informed by data on vocal signalling across species, predict that such alterations should appear globally. Here, we show acoustic differences between infant-directed and adult-directed vocalizations across cultures. We collected 1,615 recordings of infant- and adult-directed speech and song produced by 410 people in 21 urban, rural and small-scale societies. Infant-directedness was reliably classified from acoustic features only, with acoustic profiles of infant-directedness differing across language and music but in consistent fashions. We then studied listener sensitivity to these acoustic features. We played the recordings to 51,065 people from 187 countries, recruited via an English-language website, who guessed whether each vocalization was infant-directed. Their intuitions were more accurate than chance, predictable in part by common sets of acoustic features and robust to the effects of linguistic relatedness between vocalizer and listener. These findings inform hypotheses of the psychological functions and evolution of human communication.
Jagiellonian Univers... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41562-022-01410-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu36 citations 36 popularity Top 1% influence Average impulse Top 1% Powered by BIP!more_vert Jagiellonian Univers... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2016Ovid Technologies (Wolters Kluwer Health) NIH | Phase 2 Study of Mexileti..., NIH | Novel Molecular Mechanism..., CIHR +24 projectsNIH| Phase 2 Study of Mexiletine for the Treatment of Myotonic Dystrophy ,NIH| Novel Molecular Mechanisms of Neuromuscular Disease: Implications for Therapy ,CIHR ,NIH| BIOEQUIVALENCE AND CLINICAL IMPLICATIONS OF GENERIC BUPROPION ,NIH| IN VIVO NMR METABOLIC STUDY OF REGIONAL CARDIAC ISCHEMIA ,NIH| Evaluation of Treatments and Services to People with Duchenne Muscular Dystrophy ,NIH| BIOLOGY OF THE BONE MARROW DERIVED 3A1 STEM CELL ,NIH| Novel Strategy for Perioperative Beta-Blocker Therapy ,NIH| GENETICS-InFORMATICS TRIAL (GIFT) OF WARFARIN TO PREVENT DVT ,NIH| 9th International Myotonic Dystrophy Consortium Meeting ,NIH| Biiostatistics ,NIH| Disease Progression in Myotonic Dystrophy ,NIH| EXPERIMENTAL THERAPEUTICS IN NEUROLOGICAL DISEASE ,NIH| Comp A-NY State Surveillance and Research of MD and Neuromuscular Disorders ,NIH| BIOENERGETIC MECHANISMS ,NIH| POSITRON EMISSION TOMOGRAPHIC IMAGING OF LUNG TRANSPLANT ,SSHRC ,NIH| Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2 ,NIH| Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise ,NIH| Genetically Informed Smoking Cessation Trial ,NIH| Ocular Hypertension Treatment Study 20-Year Follow-up: Clinical Center Grant ,NIH| RNA-mediated mechanisms in the myotonic dystrophies ,NIH| 7th International Myotonic Dystrophy Consortium Meeting ,NIH| FOR-DMD: Double-blind randomized trial to optimize steroid regimen in Duchenne MD ,NIH| Washington University Institute of Clinical and Translational Sciences ,NIH| Tenth International Myotonic Dystrophy Consortium Meeting ,NIH| ANALYSIS OF THE E COLI STB HEAT STABLE ENTEROTOXINAuthors: Griggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; +11 AuthorsGriggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; Pestronk, Alan; Mendell, Jerry R.; Moxley, Richard T.; King, Wendy; Kissel, John T.; Cwik, Valerie; Vanasse, Michel; Florence, Julaine M.; Pandya, Shree; Dubow, Jordan S.; Meyer, James M.;Objective: To assess safety and efficacy of deflazacort (DFZ) and prednisone (PRED) vs placebo in Duchenne muscular dystrophy (DMD). Methods: This phase III, double-blind, randomized, placebo-controlled, multicenter study evaluated muscle strength among 196 boys aged 5–15 years with DMD during a 52-week period. In phase 1, participants were randomly assigned to receive treatment with DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, PRED 0.75 mg/kg/d, or placebo for 12 weeks. In phase 2, placebo participants were randomly assigned to 1 of the 3 active treatment groups. Participants originally assigned to an active treatment continued that treatment for an additional 40 weeks. The primary efficacy endpoint was average change in muscle strength from baseline to week 12 compared with placebo. The study was completed in 1995. Results: All treatment groups (DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, and PRED 0.75 mg/kg/d) demonstrated significant improvement in muscle strength compared with placebo at 12 weeks. Participants taking PRED had significantly more weight gain than placebo or both doses of DFZ at 12 weeks; at 52 weeks, participants taking PRED had significantly more weight gain than both DFZ doses. The most frequent adverse events in all 3 active treatment arms were Cushingoid appearance, erythema, hirsutism, increased weight, headache, and nasopharyngitis. Conclusions: After 12 weeks of treatment, PRED and both doses of DFZ improved muscle strength compared with placebo. Deflazacort was associated with less weight gain than PRED. Classification of evidence: This study provides Class I evidence that for boys with DMD, daily use of either DFZ and PRED is effective in preserving muscle strength over a 12-week period.
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For further information contact us at helpdesk@openaire.eu115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 0 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 France, Italy, United KingdomAmerican Association for the Advancement of Science (AAAS) SSHRC, EC | LANGELIN, SNSF | 111-Silver labelling of m... +14 projectsSSHRC ,EC| LANGELIN ,SNSF| 111-Silver labelling of monoclonal antibodies to produce selective cytotoxic agents ,NSF| Statistical Methods for Enabling Medical and Population Genomics of Admixed Human Populations ,SNSF| Islamische Diskurse und die soziale Integration von Muslimen in den USA ,NIH| Mathematical Models and Statistical Methods for Large-Scale Population Genomics ,EC| TGOFA ,UKRI| Detecting signatures of natural selection in the human genome with geographically explicit models ,EC| NEOLITHISATION ,ARC| Molecular Archaeology: Carbon isotope analysis of amino acids as a means to investigate diets, physiology, metabolism and palaeoenvironment. ,NSF| Collaborative Research: Anthropological-Genomic Effects of European Colonization on Native North Americans ,SNSF| Using time serial samples to characterize the timing ad strength of selective sweeps ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,WT ,EC| MALADAPTED ,NIH| Human Population Diversity in Leukocyte Receptors ,SNSF| Characterizing migrations with modern and ancient genomic data: the limits of the Polynesian expansionRaghavan, M.; Steinrücken, M; Harris, M; Schiffels, Stephan; DeGiorgio, Michael; Albrechtsen, M; Valdiosera, M; Ávila-Arcos, M; Malaspinas, M; Eriksson, Anders; Moltke, M; Homburger, M; Wall, Jeff; Cornejo, Omar; Moreno-Mayar, M; Korneliussen, M; Pierre, M; Rasmussen, Rasmus; Campos, Paul; de Barros Damgaard, Peter; Allentoft, M.; Lindo, John; Metspalu, M.; Rodríguez-Varela, Carlos; Mansilla, M; Henrickson, Celeste; Seguin-Orlando, M; Malmström, M; Stafford, M; Shringarpure, M; Moreno-Estrada, M; Karmin, M.; Tambets, Kristiina; Bergström, Anders; Xue, Yali; Vera, Vera; Friend, Andrew; Singarayer, M; Valdes, Paul; Balloux, François; Leboreiro, M; Vera, M; Rangel-Villalobos, M; Pettener, David; Luiselli, Donata; Davis, Loren; Heyer, M; Zollikofer, Chris; Ponce de León, M; Smith, M; Grimes, John; Pike, John; Deal, John; Fuller, M; Arriaza, Bernardo; Standen, Vivien; Luz, M.; Ricaut, M; Guidon, M; Osipova, Ludmila; Voevoda, M.; Posukh, Olga; Balanovsky, M; Lavryashina, M.; Bogunov, M; Khusnutdinova, M; Gubina, M.; Balanovska, M; Fedorova, M; Litvinov, Sergey; Malyarchuk, M; Derenko, M.; Mosher, M.; Archer, David; Cybulski, Jerome; Petzelt, Barbara; Mitchell, Joycelynn; Worl, Rosita; Norman, Paul; Parham, Peter; Kemp, Brian,; Kivisild, Toomas; Smith, Chris; Sandhu, Manjinder,; Crawford, Michael; Villems, Richard; Smith, David; Waters, Michael; Goebel, Ted; Johnson, John; Malhi, Ripan; Jakobsson, Mattias; Meltzer, David; Manica, Andrea; Durbin, Richard; Bustamante, Carlos,; Song, Yun; Nielsen, Rasmus; Willerslev, Eske; Steinrucken, M.; Harris, K.; Rasmussen, S.; Albrechtsen, A.; Valdiosera, C.; Avila-Arcos, M.; Malaspinas, S.; Moltke, I.; Homburger, J.; Moreno-Mayar, J.; Korneliussen, S.; Pierre, T.; Rasmussen, M.; Damgaard, P.; Metspalu, E.; Rodriguez-Varela, R.; Mansilla, J.; Seguin-Orlando, A.; Malmstrom, H.; Stafford, T.; Shringarpure, S.; Moreno-Estrada, A.; Bergstrom, A.; Warmuth, V.; Singarayer, J.; Leboreiro, I.; Vera, J.; Rangel-Villalobos, H.; Heyer, E.; Ponce De Leon, M.; Grimes, V.; Pike, K.; Deal, M.; Fuller, T.; Ricaut, F.; Guidon, N.; Balanovsky, O.; Bogunov, Y.; Khusnutdinova, E.; Balanovska, E.; Fedorova, S.; Malyarchuk, B.; Norman, J.; Kemp, M.; Malhi, S.; Meltzer, J.; Song, S.;How and when the Americas were populated remains contentious. Using ancient and modern genome wide data we found that the ancestors of all present day Native Americans including Athabascans and Amerindians entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000 year isolation period in Beringia. After their arrival to the Americas ancestral Native Americans diversified into two basal genetic branches around 13 ka one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present day East Asians (including Siberians) and more distantly Australo Melanesians. Putative “Paleoamerican” relict populations including the historical Mexican Pericúes and South American Fuego Patagonians are not directly related to modern Australo Melanesians as suggested by the Paleoamerican Model. INTRODUCTION The consensus view on the peopling of the Americas is that ancestors of modern Native Americans entered the Americas from Siberia via the Bering Land Bridge and that this occurred at least {\textasciitilde}14.6 thousand years ago (ka). However the number and timing of migrations into the Americas remain controversial with conflicting interpretations based on anatomical and genetic evidence. RATIONALE In this study we address four major unresolved issues regarding the Pleistocene and recent population history of Native Americans: (i) the timing of their divergence from their ancestral group (ii) the number of migrations into the Americas (iii) whether there was {\textasciitilde}15000 years of isolation of ancestral Native Americans in Beringia (Beringian Incubation Model) and (iv) whether there was post Pleistocene survival of relict populations in the Americas related to Australo Melanesians as suggested by apparent differences in cranial morphologies between some early (“Paleoamerican”) remains and those of more recent Native Americans. We generated 31 high coverage modern genomes from the Americas Siberia and Oceania; 23 ancient genomic sequences from the Americas dating between {\textasciitilde}0.2 and 6 ka; and SNP chip genotype data from 79 present day individuals belonging to 28 populations from the Americas and Siberia. The above data sets were analyzed together with published modern and ancient genomic data from worldwide populations after masking some present day Native Americans for recent European admixture. RESULTS Using three different methods we determined the divergence time for all Native Americans (Athabascans and Amerindians) from their Siberian ancestors to be {\textasciitilde}20 ka and no earlier than {\textasciitilde}23 ka. Furthermore we dated the divergence between Athabascans (northern Native American branch together with northern North American Amerindians) and southern North Americans and South and Central Americans (southern Native American branch) to be {\textasciitilde}13 ka. Similar divergence times from East Asian populations and a divergence time between the two branches that is close in age to the earliest well established archaeological sites in the Americas suggest that the split between the branches occurred within the Americas. We additionally found that several sequenced Holocene individuals from the Americas are related to present day populations from the same geographical regions implying genetic continuity of ancient and modern populations in some parts of the Americas over at least the past 8500 years. Moreover our results suggest that there has been gene flow between some Native Americans from both North and South America and groups related to East Asians and Australo Melanesians the latter possibly through an East Asian route that might have included ancestors of modern Aleutian Islanders. Last using both genomic and morphometric analyses we found that historical Native American groups such as the Pericúes and Fuego Patagonians were not “relicts” of Paleoamericans and hence our results do not support an early migration of populations directly related to Australo Melanesians into the Americas. CONCLUSION Our results provide an upper bound of {\textasciitilde}23 ka on the initial divergence of ancestral Native Americans from their East Asian ancestors followed by a short isolation period of no more than {\textasciitilde}8000 years and subsequent entrance and spread across the Americas. The data presented are consistent with a single migration model for all Native Americans with later gene flow from sources related to East Asians and indirectly Australo Melanesians. The single wave diversified {\textasciitilde}13 ka likely within the Americas giving rise to the northern and southern branches of present day Native Americans. View larger version: In this page In a new window Download PowerPoint Slide for Teaching Population history of present day Native Americans.The ancestors of all Native Americans entered the Americas as a single migration wave from Siberia (purple) no earlier than {\textasciitilde}23 ka separate from the Inuit (green) and diversified into “northern” and “southern” Native American branches {\textasciitilde}13 ka. There is evidence of post divergence gene flow between some Native Americans and groups related to East Asians/Inuit and Australo Melanesians (yellow). Genetic history of Native Americans Several theories have been put forth as to the origin and timing of when Native American ancestors entered the Americas. To clarify this controversy Raghavan et al. examined the genomic variation among ancient and modern individuals from Asia and the Americas. There is no evidence for multiple waves of entry or recurrent gene flow with Asians in northern populations. The earliest migrations occurred no earlier than 23000 years ago from Siberian ancestors. Amerindians and Athabascans originated from a single population splitting approximately 13000 years ago. Science this issue 10.1126/science.aab3884
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For further information contact us at helpdesk@openaire.eu407 citations 407 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010 United States, CanadaPublic Library of Science (PLoS) CIHR, SSHRC, NIH | Center for AIDS ResearchCIHR ,SSHRC ,NIH| Center for AIDS ResearchAngela Kaida; Fatima Laher; Steffanie A. Strathdee; Deborah Money; Patricia A. Janssen; Robert S. Hogg; Glenda Gray;Objective Preventing unintended pregnancy among HIV-positive women constitutes a critical and cost-effective approach to primary prevention of mother-to-child transmission of HIV and is a global public health priority for addressing the desperate state of maternal and child health in HIV hyper-endemic settings. We sought to investigate whether the prevalence of contraceptive use and method preferences varied by HIV status and receipt of highly active antiretroviral therapy (HAART) among women in Soweto, South Africa. Methods We used survey data from 563 sexually active, non-pregnant women (18–44 years) recruited from the Perinatal HIV Research Unit in Soweto (May–December, 2007); 171 women were HIV-positive and receiving HAART (median duration of use = 31 months; IQR = 28, 33), 178 were HIV-positive and HAART-naive, and 214 were HIV-negative. Medical record review was conducted to confirm HIV status and clinical variables. Logistic regression models estimated adjusted associations between HIV status, receipt of HAART, and contraceptive use. Results Overall, 78% of women reported using contraception, with significant variation by HIV status: 86% of HAART users, 82% of HAART-naive women, and 69% of HIV-negative women (p<0.0001). In adjusted models, compared with HIV-negative women, women receiving HAART were significantly more likely to use contraception while HAART-naive women were non-significantly more likely (AOR: 2.40; 95% CI: 1.25, 4.62 and AOR: 1.59; 95% CI: 0.88, 2.85; respectively). Among HIV-positive women, HAART users were non-significantly more likely to use contraception compared with HAART-naive women (AOR: 1.55; 95% CI: 0.84, 2.88). Similar patterns held for specific use of barrier (primarily male condoms), permanent, and dual protection contraceptive methods. Conclusion Among HIV-positive women receiving HAART, the observed higher prevalence of contraceptive use overall and condoms in particular promises to yield fewer unintended pregnancies and reduced risks of vertical and sexual HIV transmission. These findings highlight the potential of integrated HIV and reproductive health services to positively impact maternal, partner, and child health.
Europe PubMed Centra... arrow_drop_down Simon Fraser University Institutional RepositoryArticle . 2010Data sources: Simon Fraser University Institutional RepositoryeScholarship - University of CaliforniaArticle . 2010Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu81 citations 81 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Simon Fraser University Institutional RepositoryArticle . 2010Data sources: Simon Fraser University Institutional RepositoryeScholarship - University of CaliforniaArticle . 2010Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 English NIH | Longitudinal Study of Vag..., SSHRC, NSERC +4 projectsNIH| Longitudinal Study of Vaginal Microbiota and Persistent Human Papillomavirus Detection ,SSHRC ,NSERC ,ANR| CHESS ,NIH| Global Health Equity Scholars Program - D43 Fogarty Training ,AKA| Intra-Genomic Conflicts and Social Decision-Making in Humans ,NIH| Psychological functions of music in infancyMoser, Cody J.; Lee-Rubin, Harry; Bainbridge, Constance M.; Atwood, S.; Simson, Jan; Knox, Dean; Glowacki, Luke; Galbarczyk, Andrzej; Jasienska, Grazyna; Ross, Cody T.; Neff, Mary Beth; Martin, Alia; Cirelli, Laura K.; Trehub, Sandra E.; Song, Jinqi; Kim, Minju; Schachner, Adena; Vardy, Tom A.; Atkinson, Quentin D.; Antfolk, Jan; Madhivanan, Purnima; Siddaiah, Anand; Placek, Caitlyn D.; Salali, Gul Deniz; Keestra, Sarai; Singh, Manvir; Collins, Scott A.; Patton, John Q.; Scaff, Camila; Stieglitz, Jonathan; Moya, Cristina; Sagar, Rohan R.; Wood, Brian M.; Krasnow, Max M.; Mehr, Samuel A.;Abstract Humans often produce vocalizations for infants that differ from vocalizations for adults. Is this property common across societies? The forms of infant-directed vocalizations may be shaped by their function in parent-infant communication. If so, infant-directed song and speech should be differentiable from adult-directed song and speech on the basis of their acoustic features, and this property should be relatively invariant across cultures. To test this hypothesis, we built a corpus of 1,614 recordings of infant- and adult-directed singing and speech produced by 411 people living in 21 urban, rural, and small-scale societies. We studied the corpus in a massive online experiment and in a series of acoustic analyses. Naïve listeners ( N = 13,218) reliably identified infant-directed vocalizations as infant-directed, and adult-directed speech (but not songs) as adult-directed, at rates far higher than chance. Ratings of infant-directed song were the most accurate and the most consistent across all societies; infant-directed speech was accurately identified on average, but inconsistently across societies. To determine the mechanisms underlying these results, we extracted many acoustic features from each recording and identified those that most reliably characterize infant-directed song and speech across cultures, via preregistered exploratory-confirmatory analyses and machine classification. The features distinguishing infant- and adult-directed song and speech concerned pitch, rhythmic, phonetic, and timbral attributes; a hypothesis-free classifier with cross-validation across societies reliably identified all vocalization types, with highest accuracy for infant-directed song. Last, we isolated 12 acoustic features that were predictive of perceived infant-directedness; of these, two pitch attributes (median F0 and its variability) were by far the most explanatory. These findings demonstrate cross-cultural regularities in infant-directed vocalizations that are suggestive of universality; moreover, infant-directed song appears to be more cross-culturally stereotyped than infant-directed speech, informing hypotheses of the functions and evolution of both.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Netherlands, Poland, United StatesSpringer Science and Business Media LLC NSERC, NIH | Longitudinal Study of Vag..., SSHRC +4 projectsNSERC ,NIH| Longitudinal Study of Vaginal Microbiota and Persistent Human Papillomavirus Detection ,SSHRC ,NIH| Psychological functions of music in infancy ,ANR| CHESS ,NIH| Global Health Equity Scholars Program - D43 Fogarty Training ,AKA| Intra-Genomic Conflicts and Social Decision-Making in HumansCourtney B. Hilton; Cody J. Moser; Mila Bertolo; Harry Lee-Rubin; Dorsa Amir; Constance M. Bainbridge; Jan Simson; Dean Knox; Luke Glowacki; Elias Alemu; Andrzej Galbarczyk; Grazyna Jasienska; Cody T. Ross; Mary Beth Neff; Alia Martin; Laura K. Cirelli; Sandra E. Trehub; Jinqi Song; Minju Kim; Adena Schachner; Tom A. Vardy; Quentin D. Atkinson; Amanda Salenius; Jannik Andelin; Jan Antfolk; Purnima Madhivanan; Anand Siddaiah; Caitlyn D. Placek; Gul Deniz Salali; Sarai Keestra; Manvir Singh; Scott A. Collins; John Q. Patton; Camila Scaff; Jonathan Stieglitz; Silvia Ccari Cutipa; Cristina Moya; Rohan R. Sagar; Mariamu Anyawire; Audax Mabulla; Brian M. Wood; Max M. Krasnow; Samuel A. Mehr;National audience; When interacting with infants, humans often alter their speech and song in ways thought to support communication. Theories of human child-rearing, informed by data on vocal signalling across species, predict that such alterations should appear globally. Here, we show acoustic differences between infant-directed and adult-directed vocalizations across cultures. We collected 1,615 recordings of infant- and adult-directed speech and song produced by 410 people in 21 urban, rural and small-scale societies. Infant-directedness was reliably classified from acoustic features only, with acoustic profiles of infant-directedness differing across language and music but in consistent fashions. We then studied listener sensitivity to these acoustic features. We played the recordings to 51,065 people from 187 countries, recruited via an English-language website, who guessed whether each vocalization was infant-directed. Their intuitions were more accurate than chance, predictable in part by common sets of acoustic features and robust to the effects of linguistic relatedness between vocalizer and listener. These findings inform hypotheses of the psychological functions and evolution of human communication.
Jagiellonian Univers... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu36 citations 36 popularity Top 1% influence Average impulse Top 1% Powered by BIP!more_vert Jagiellonian Univers... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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