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description Publicationkeyboard_double_arrow_right Article 2016Ovid Technologies (Wolters Kluwer Health) NIH | Phase 2 Study of Mexileti..., NIH | Novel Molecular Mechanism..., CIHR +24 projectsNIH| Phase 2 Study of Mexiletine for the Treatment of Myotonic Dystrophy ,NIH| Novel Molecular Mechanisms of Neuromuscular Disease: Implications for Therapy ,CIHR ,NIH| BIOEQUIVALENCE AND CLINICAL IMPLICATIONS OF GENERIC BUPROPION ,NIH| IN VIVO NMR METABOLIC STUDY OF REGIONAL CARDIAC ISCHEMIA ,NIH| Evaluation of Treatments and Services to People with Duchenne Muscular Dystrophy ,NIH| BIOLOGY OF THE BONE MARROW DERIVED 3A1 STEM CELL ,NIH| Novel Strategy for Perioperative Beta-Blocker Therapy ,NIH| GENETICS-InFORMATICS TRIAL (GIFT) OF WARFARIN TO PREVENT DVT ,NIH| 9th International Myotonic Dystrophy Consortium Meeting ,NIH| Biiostatistics ,NIH| Disease Progression in Myotonic Dystrophy ,NIH| EXPERIMENTAL THERAPEUTICS IN NEUROLOGICAL DISEASE ,NIH| Comp A-NY State Surveillance and Research of MD and Neuromuscular Disorders ,NIH| BIOENERGETIC MECHANISMS ,NIH| POSITRON EMISSION TOMOGRAPHIC IMAGING OF LUNG TRANSPLANT ,SSHRC ,NIH| Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2 ,NIH| Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise ,NIH| Genetically Informed Smoking Cessation Trial ,NIH| Ocular Hypertension Treatment Study 20-Year Follow-up: Clinical Center Grant ,NIH| RNA-mediated mechanisms in the myotonic dystrophies ,NIH| 7th International Myotonic Dystrophy Consortium Meeting ,NIH| FOR-DMD: Double-blind randomized trial to optimize steroid regimen in Duchenne MD ,NIH| Washington University Institute of Clinical and Translational Sciences ,NIH| Tenth International Myotonic Dystrophy Consortium Meeting ,NIH| ANALYSIS OF THE E COLI STB HEAT STABLE ENTEROTOXINAuthors: Griggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; +11 AuthorsGriggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; Pestronk, Alan; Mendell, Jerry R.; Moxley, Richard T.; King, Wendy; Kissel, John T.; Cwik, Valerie; Vanasse, Michel; Florence, Julaine M.; Pandya, Shree; Dubow, Jordan S.; Meyer, James M.;Objective: To assess safety and efficacy of deflazacort (DFZ) and prednisone (PRED) vs placebo in Duchenne muscular dystrophy (DMD). Methods: This phase III, double-blind, randomized, placebo-controlled, multicenter study evaluated muscle strength among 196 boys aged 5–15 years with DMD during a 52-week period. In phase 1, participants were randomly assigned to receive treatment with DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, PRED 0.75 mg/kg/d, or placebo for 12 weeks. In phase 2, placebo participants were randomly assigned to 1 of the 3 active treatment groups. Participants originally assigned to an active treatment continued that treatment for an additional 40 weeks. The primary efficacy endpoint was average change in muscle strength from baseline to week 12 compared with placebo. The study was completed in 1995. Results: All treatment groups (DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, and PRED 0.75 mg/kg/d) demonstrated significant improvement in muscle strength compared with placebo at 12 weeks. Participants taking PRED had significantly more weight gain than placebo or both doses of DFZ at 12 weeks; at 52 weeks, participants taking PRED had significantly more weight gain than both DFZ doses. The most frequent adverse events in all 3 active treatment arms were Cushingoid appearance, erythema, hirsutism, increased weight, headache, and nasopharyngitis. Conclusions: After 12 weeks of treatment, PRED and both doses of DFZ improved muscle strength compared with placebo. Deflazacort was associated with less weight gain than PRED. Classification of evidence: This study provides Class I evidence that for boys with DMD, daily use of either DFZ and PRED is effective in preserving muscle strength over a 12-week period.
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For further information contact us at helpdesk@openaire.eu115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 0 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United StatesPublic Library of Science (PLoS) SSHRC, NIH | The National Person-Cente..., NIH | University of Pittsburgh ... +2 projectsSSHRC ,NIH| The National Person-Centered Assessment Resource (PCAR) ,NIH| University of Pittsburgh Clinical and Translational Science Institute ,NIH| PROMIS Statistical Center ,NIH| Institutional Career DevelopmentHanmer, Janel; Dewitt, Barry; Yu, Lan; Tsevat, Joel; Roberts, Mark; Revicki, Dennis; Pilkonis, Paul A.; Hess, Rachel; Hays, Ron D.; Fischhoff, Baruch; Feeny, David; Condon, David; Cella, David;Author(s): Hanmer, Janel; Dewitt, Barry; Yu, Lan; Tsevat, Joel; Roberts, Mark; Revicki, Dennis; Pilkonis, Paul A; Hess, Rachel; Hays, Ron D; Fischhoff, Baruch; Feeny, David; Condon, David; Cella, David | Abstract: ObjectivesThe PROMIS-Preference (PROPr) score is a recently developed summary score for the Patient-Reported Outcomes Measurement Information System (PROMIS). PROPr is a preference-based scoring system for seven PROMIS domains created using multiplicative multi-attribute utility theory. It serves as a generic, societal, preference-based summary scoring system of health-related quality of life. This manuscript evaluates construct validity of PROPr in two large samples from the US general population.MethodsWe utilized 2 online panel surveys, the PROPr Estimation Survey and the Profiles-Health Utilities Index (HUI) Survey. Both included the PROPr measure, patient demographic information, self-reported chronic conditions, and other preference-based summary scores: the EuroQol-5D (EQ-5D-5L) and HUI in the PROPr Estimation Survey and the HUI in the Profiles-HUI Survey. The HUI was scored as both the Mark 2 and the Mark 3. Known-groups validity was evaluated using age- and gender-stratified mean scores and health condition impact estimates. Condition impact estimates were created using ordinary least squares regression in which a summary score was regressed on age, gender, and a single health condition. The coefficient for the health condition is the estimated effect on the preference score of having a condition vs. not having it. Convergent validity was evaluated using Pearson correlations between PROPr and other summary scores.ResultsThe sample consisted of 983 respondents from the PROPr Estimation Survey and 3,000 from the Profiles-HUI survey. Age- and gender-stratified mean PROPr scores were lower than EQ-5D and HUI scores, with fewer subjects having scores corresponding to perfect health on the PROPr. In the PROPr Estimation survey, all 11 condition impact estimates were statistically significant using PROPr, 8 were statistically significant by the EQ-5D, 7 were statistically significant by HUI Mark 2, and 9 were statistically significant by HUI Mark 3. In the Profiles-HUI survey, all 21 condition impact estimates were statistically significant using summary scores from all three scoring systems. In these samples, the correlations between PROPr and the other summary measures ranged from 0.67 to 0.70.ConclusionsThese results provide evidence of construct validity for PROPr using samples from the US general population.
Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Collection 2018Figshare NIH | PROMIS Statistical Center, SSHRCNIH| PROMIS Statistical Center ,SSHRCDewitt, Barry; Feeny, David; Fischhoff, Baruch; Cella, David; Hays, Ron D.; Hess, Rachel; Pilkonis, Paul A.; Revicki, Dennis A.; Roberts, Mark S.; Tsevat, Joel; Yu, Lan; Hanmer, Janel;Background. Health-related quality of life (HRQL) preference-based scores are used to assess the health of populations and patients and for cost-effectiveness analyses. The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS®) consists of patient-reported outcome measures developed using item response theory. PROMIS is in need of a direct preference-based scoring system for assigning values to health states. Objective. To produce societal preference-based scores for 7 PROMIS domains: Cognitive Function–Abilities, Depression, Fatigue, Pain Interference, Physical Function, Sleep Disturbance, and Ability to Participate in Social Roles and Activities. Setting. Online survey of a US nationally representative sample (n = 983). Methods. Preferences for PROMIS health states were elicited with the standard gamble to obtain both single-attribute scoring functions for each of the 7 PROMIS domains and a multiplicative multiattribute utility (scoring) function. Results. The 7 single-attribute scoring functions were fit using isotonic regression with linear interpolation. The multiplicative multiattribute summary function estimates utilities for PROMIS multiattribute health states on a scale where 0 is the utility of being dead and 1 the utility of “full health.” The lowest possible score is –0.022 (for a state viewed as worse than dead), and the highest possible score is 1. Limitations. The online survey systematically excludes some subgroups, such as the visually impaired and illiterate. Conclusions. A generic societal preference-based scoring system is now available for all studies using these 7 PROMIS health domains.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United StatesSAGE Publications SSHRC, NIH | PROMIS Statistical CenterSSHRC ,NIH| PROMIS Statistical CenterBarry Dewitt; David Feeny; Baruch Fischhoff; David Cella; Ron D. Hays; Rachel Hess; Paul A. Pilkonis; Dennis A. Revicki; Mark S. Roberts; Joel Tsevat; Lan Yu; Janel Hanmer;Background. Health-related quality of life (HRQL) preference-based scores are used to assess the health of populations and patients and for cost-effectiveness analyses. The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS®) consists of patient-reported outcome measures developed using item response theory. PROMIS is in need of a direct preference-based scoring system for assigning values to health states. Objective. To produce societal preference-based scores for 7 PROMIS domains: Cognitive Function–Abilities, Depression, Fatigue, Pain Interference, Physical Function, Sleep Disturbance, and Ability to Participate in Social Roles and Activities. Setting. Online survey of a US nationally representative sample ( n = 983). Methods. Preferences for PROMIS health states were elicited with the standard gamble to obtain both single-attribute scoring functions for each of the 7 PROMIS domains and a multiplicative multiattribute utility (scoring) function. Results. The 7 single-attribute scoring functions were fit using isotonic regression with linear interpolation. The multiplicative multiattribute summary function estimates utilities for PROMIS multiattribute health states on a scale where 0 is the utility of being dead and 1 the utility of “full health.” The lowest possible score is –0.022 (for a state viewed as worse than dead), and the highest possible score is 1. Limitations. The online survey systematically excludes some subgroups, such as the visually impaired and illiterate. Conclusions. A generic societal preference-based scoring system is now available for all studies using these 7 PROMIS health domains.
eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu57 citations 57 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0272989x18776637&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2018SAGE Journals SSHRC, NIH | PROMIS Statistical CenterSSHRC ,NIH| PROMIS Statistical CenterDewitt, Barry; Feeny, David; Fischhoff, Baruch; Cella, David; Hays, Ron D.; Hess, Rachel; Pilkonis, Paul A.; Revicki, Dennis A.; Roberts, Mark S.; Tsevat, Joel; Yu, Lan; Hanmer, Janel;Supplemental material, DS_10.1177_0272989X18776637 for Estimation of a Preference-Based Summary Score for the Patient-Reported Outcomes Measurement Information System: The PROMIS®-Preference (PROPr) Scoring System by Barry Dewitt, David Feeny, Baruch Fischhoff, David Cella, Ron D. Hays, Rachel Hess, Paul A. Pilkonis, Dennis A. Revicki, Mark S. Roberts, Joel Tsevat, Lan Yu and Janel Hanmer in Medical Decision Making
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2016Ovid Technologies (Wolters Kluwer Health) NIH | Phase 2 Study of Mexileti..., NIH | Novel Molecular Mechanism..., CIHR +24 projectsNIH| Phase 2 Study of Mexiletine for the Treatment of Myotonic Dystrophy ,NIH| Novel Molecular Mechanisms of Neuromuscular Disease: Implications for Therapy ,CIHR ,NIH| BIOEQUIVALENCE AND CLINICAL IMPLICATIONS OF GENERIC BUPROPION ,NIH| IN VIVO NMR METABOLIC STUDY OF REGIONAL CARDIAC ISCHEMIA ,NIH| Evaluation of Treatments and Services to People with Duchenne Muscular Dystrophy ,NIH| BIOLOGY OF THE BONE MARROW DERIVED 3A1 STEM CELL ,NIH| Novel Strategy for Perioperative Beta-Blocker Therapy ,NIH| GENETICS-InFORMATICS TRIAL (GIFT) OF WARFARIN TO PREVENT DVT ,NIH| 9th International Myotonic Dystrophy Consortium Meeting ,NIH| Biiostatistics ,NIH| Disease Progression in Myotonic Dystrophy ,NIH| EXPERIMENTAL THERAPEUTICS IN NEUROLOGICAL DISEASE ,NIH| Comp A-NY State Surveillance and Research of MD and Neuromuscular Disorders ,NIH| BIOENERGETIC MECHANISMS ,NIH| POSITRON EMISSION TOMOGRAPHIC IMAGING OF LUNG TRANSPLANT ,SSHRC ,NIH| Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2 ,NIH| Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise ,NIH| Genetically Informed Smoking Cessation Trial ,NIH| Ocular Hypertension Treatment Study 20-Year Follow-up: Clinical Center Grant ,NIH| RNA-mediated mechanisms in the myotonic dystrophies ,NIH| 7th International Myotonic Dystrophy Consortium Meeting ,NIH| FOR-DMD: Double-blind randomized trial to optimize steroid regimen in Duchenne MD ,NIH| Washington University Institute of Clinical and Translational Sciences ,NIH| Tenth International Myotonic Dystrophy Consortium Meeting ,NIH| ANALYSIS OF THE E COLI STB HEAT STABLE ENTEROTOXINAuthors: Griggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; +11 AuthorsGriggs, Robert C.; Miller, J. Phillip; Greenberg, Cheryl R.; Fehlings, Darcy L.; Pestronk, Alan; Mendell, Jerry R.; Moxley, Richard T.; King, Wendy; Kissel, John T.; Cwik, Valerie; Vanasse, Michel; Florence, Julaine M.; Pandya, Shree; Dubow, Jordan S.; Meyer, James M.;Objective: To assess safety and efficacy of deflazacort (DFZ) and prednisone (PRED) vs placebo in Duchenne muscular dystrophy (DMD). Methods: This phase III, double-blind, randomized, placebo-controlled, multicenter study evaluated muscle strength among 196 boys aged 5–15 years with DMD during a 52-week period. In phase 1, participants were randomly assigned to receive treatment with DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, PRED 0.75 mg/kg/d, or placebo for 12 weeks. In phase 2, placebo participants were randomly assigned to 1 of the 3 active treatment groups. Participants originally assigned to an active treatment continued that treatment for an additional 40 weeks. The primary efficacy endpoint was average change in muscle strength from baseline to week 12 compared with placebo. The study was completed in 1995. Results: All treatment groups (DFZ 0.9 mg/kg/d, DFZ 1.2 mg/kg/d, and PRED 0.75 mg/kg/d) demonstrated significant improvement in muscle strength compared with placebo at 12 weeks. Participants taking PRED had significantly more weight gain than placebo or both doses of DFZ at 12 weeks; at 52 weeks, participants taking PRED had significantly more weight gain than both DFZ doses. The most frequent adverse events in all 3 active treatment arms were Cushingoid appearance, erythema, hirsutism, increased weight, headache, and nasopharyngitis. Conclusions: After 12 weeks of treatment, PRED and both doses of DFZ improved muscle strength compared with placebo. Deflazacort was associated with less weight gain than PRED. Classification of evidence: This study provides Class I evidence that for boys with DMD, daily use of either DFZ and PRED is effective in preserving muscle strength over a 12-week period.
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For further information contact us at helpdesk@openaire.eu115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 0 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United StatesPublic Library of Science (PLoS) SSHRC, NIH | The National Person-Cente..., NIH | University of Pittsburgh ... +2 projectsSSHRC ,NIH| The National Person-Centered Assessment Resource (PCAR) ,NIH| University of Pittsburgh Clinical and Translational Science Institute ,NIH| PROMIS Statistical Center ,NIH| Institutional Career DevelopmentHanmer, Janel; Dewitt, Barry; Yu, Lan; Tsevat, Joel; Roberts, Mark; Revicki, Dennis; Pilkonis, Paul A.; Hess, Rachel; Hays, Ron D.; Fischhoff, Baruch; Feeny, David; Condon, David; Cella, David;Author(s): Hanmer, Janel; Dewitt, Barry; Yu, Lan; Tsevat, Joel; Roberts, Mark; Revicki, Dennis; Pilkonis, Paul A; Hess, Rachel; Hays, Ron D; Fischhoff, Baruch; Feeny, David; Condon, David; Cella, David | Abstract: ObjectivesThe PROMIS-Preference (PROPr) score is a recently developed summary score for the Patient-Reported Outcomes Measurement Information System (PROMIS). PROPr is a preference-based scoring system for seven PROMIS domains created using multiplicative multi-attribute utility theory. It serves as a generic, societal, preference-based summary scoring system of health-related quality of life. This manuscript evaluates construct validity of PROPr in two large samples from the US general population.MethodsWe utilized 2 online panel surveys, the PROPr Estimation Survey and the Profiles-Health Utilities Index (HUI) Survey. Both included the PROPr measure, patient demographic information, self-reported chronic conditions, and other preference-based summary scores: the EuroQol-5D (EQ-5D-5L) and HUI in the PROPr Estimation Survey and the HUI in the Profiles-HUI Survey. The HUI was scored as both the Mark 2 and the Mark 3. Known-groups validity was evaluated using age- and gender-stratified mean scores and health condition impact estimates. Condition impact estimates were created using ordinary least squares regression in which a summary score was regressed on age, gender, and a single health condition. The coefficient for the health condition is the estimated effect on the preference score of having a condition vs. not having it. Convergent validity was evaluated using Pearson correlations between PROPr and other summary scores.ResultsThe sample consisted of 983 respondents from the PROPr Estimation Survey and 3,000 from the Profiles-HUI survey. Age- and gender-stratified mean PROPr scores were lower than EQ-5D and HUI scores, with fewer subjects having scores corresponding to perfect health on the PROPr. In the PROPr Estimation survey, all 11 condition impact estimates were statistically significant using PROPr, 8 were statistically significant by the EQ-5D, 7 were statistically significant by HUI Mark 2, and 9 were statistically significant by HUI Mark 3. In the Profiles-HUI survey, all 21 condition impact estimates were statistically significant using summary scores from all three scoring systems. In these samples, the correlations between PROPr and the other summary measures ranged from 0.67 to 0.70.ConclusionsThese results provide evidence of construct validity for PROPr using samples from the US general population.
Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0201093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Collection 2018Figshare NIH | PROMIS Statistical Center, SSHRCNIH| PROMIS Statistical Center ,SSHRCDewitt, Barry; Feeny, David; Fischhoff, Baruch; Cella, David; Hays, Ron D.; Hess, Rachel; Pilkonis, Paul A.; Revicki, Dennis A.; Roberts, Mark S.; Tsevat, Joel; Yu, Lan; Hanmer, Janel;Background. Health-related quality of life (HRQL) preference-based scores are used to assess the health of populations and patients and for cost-effectiveness analyses. The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS®) consists of patient-reported outcome measures developed using item response theory. PROMIS is in need of a direct preference-based scoring system for assigning values to health states. Objective. To produce societal preference-based scores for 7 PROMIS domains: Cognitive Function–Abilities, Depression, Fatigue, Pain Interference, Physical Function, Sleep Disturbance, and Ability to Participate in Social Roles and Activities. Setting. Online survey of a US nationally representative sample (n = 983). Methods. Preferences for PROMIS health states were elicited with the standard gamble to obtain both single-attribute scoring functions for each of the 7 PROMIS domains and a multiplicative multiattribute utility (scoring) function. Results. The 7 single-attribute scoring functions were fit using isotonic regression with linear interpolation. The multiplicative multiattribute summary function estimates utilities for PROMIS multiattribute health states on a scale where 0 is the utility of being dead and 1 the utility of “full health.” The lowest possible score is –0.022 (for a state viewed as worse than dead), and the highest possible score is 1. Limitations. The online survey systematically excludes some subgroups, such as the visually impaired and illiterate. Conclusions. A generic societal preference-based scoring system is now available for all studies using these 7 PROMIS health domains.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25384/sage.c.4160660.v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25384/sage.c.4160660.v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United StatesSAGE Publications SSHRC, NIH | PROMIS Statistical CenterSSHRC ,NIH| PROMIS Statistical CenterBarry Dewitt; David Feeny; Baruch Fischhoff; David Cella; Ron D. Hays; Rachel Hess; Paul A. Pilkonis; Dennis A. Revicki; Mark S. Roberts; Joel Tsevat; Lan Yu; Janel Hanmer;Background. Health-related quality of life (HRQL) preference-based scores are used to assess the health of populations and patients and for cost-effectiveness analyses. The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS®) consists of patient-reported outcome measures developed using item response theory. PROMIS is in need of a direct preference-based scoring system for assigning values to health states. Objective. To produce societal preference-based scores for 7 PROMIS domains: Cognitive Function–Abilities, Depression, Fatigue, Pain Interference, Physical Function, Sleep Disturbance, and Ability to Participate in Social Roles and Activities. Setting. Online survey of a US nationally representative sample ( n = 983). Methods. Preferences for PROMIS health states were elicited with the standard gamble to obtain both single-attribute scoring functions for each of the 7 PROMIS domains and a multiplicative multiattribute utility (scoring) function. Results. The 7 single-attribute scoring functions were fit using isotonic regression with linear interpolation. The multiplicative multiattribute summary function estimates utilities for PROMIS multiattribute health states on a scale where 0 is the utility of being dead and 1 the utility of “full health.” The lowest possible score is –0.022 (for a state viewed as worse than dead), and the highest possible score is 1. Limitations. The online survey systematically excludes some subgroups, such as the visually impaired and illiterate. Conclusions. A generic societal preference-based scoring system is now available for all studies using these 7 PROMIS health domains.
eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0272989x18776637&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu57 citations 57 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0272989x18776637&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2018SAGE Journals SSHRC, NIH | PROMIS Statistical CenterSSHRC ,NIH| PROMIS Statistical CenterDewitt, Barry; Feeny, David; Fischhoff, Baruch; Cella, David; Hays, Ron D.; Hess, Rachel; Pilkonis, Paul A.; Revicki, Dennis A.; Roberts, Mark S.; Tsevat, Joel; Yu, Lan; Hanmer, Janel;Supplemental material, DS_10.1177_0272989X18776637 for Estimation of a Preference-Based Summary Score for the Patient-Reported Outcomes Measurement Information System: The PROMIS®-Preference (PROPr) Scoring System by Barry Dewitt, David Feeny, Baruch Fischhoff, David Cella, Ron D. Hays, Rachel Hess, Paul A. Pilkonis, Dennis A. Revicki, Mark S. Roberts, Joel Tsevat, Lan Yu and Janel Hanmer in Medical Decision Making
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25384/sage.6802154&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25384/sage.6802154&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu