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description Publicationkeyboard_double_arrow_right Article , Other literature type 2013 Denmark, SwitzerlandAmerican Association for the Advancement of Science (AAAS) SSHRC, EC | APGREIDSSHRC ,EC| APGREIDVerena J, Schuenemann; Pushpendra, Singh; Thomas A, Mendum; Ben, Krause-Kyora; Günter, Jäger; Kirsten I, Bos; Alexander, Herbig; Christos, Economou; Andrej, Benjak; Philippe, Busso; Almut, Nebel; Jesper L, Boldsen; Anna, Kjellström; Huihai, Wu; Graham R, Stewart; G Michael, Taylor; Peter, Bauer; Oona Y-C, Lee; Houdini H T, Wu; David E, Minnikin; Gurdyal S, Besra; Katie, Tucker; Simon, Roffey; Samba O, Sow; Stewart T, Cole; Kay, Nieselt; Johannes, Krause;pmid: 23765279
Leprosy: Ancient and Modern In medieval Europe, leprosy was greatly feared: Sufferers had to wear bells and were shunned and kept isolated from society. Although leprosy largely disappeared from Europe in the 16th century, elsewhere in the world almost a quarter of a million cases are still reported annually, despite the availability of effective drugs. Schuenemann et al. (p. 179 , published online 13 June; see the 14 June News story by Gibbons , p. 1278 ) probed the origins of leprosy bacilli by using a genomic capture-based approach on DNA obtained from skeletal remains from the 10th to 14th centuries. Because the unique mycolic acids of this mycobacterium protect its DNA, for one Danish sample over 100-fold, coverage of the genome was possible. Sequencing suggests a link between the middle-eastern and medieval European strains, which falls in line with social historical expectations that the returning expeditionary forces of antiquity originally spread the pathogen. Subsequently, Europeans took the bacterium westward to the Americas. Overall, ancient and modern strains remain remarkably similar, with no apparent loss of virulence genes, indicating it was most probably improvements in social conditions that led to leprosy's demise in Europe.
University of Southe... arrow_drop_down University of Southern Denmark Research OutputArticle . 2013Data sources: University of Southern Denmark Research OutputInfoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsScienceArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu301 citations 301 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert University of Southe... arrow_drop_down University of Southern Denmark Research OutputArticle . 2013Data sources: University of Southern Denmark Research OutputInfoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsScienceArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/science.1238286&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Spain, Switzerland, ArgentinaSpringer Science and Business Media LLC SSHRC, EC | APGREIDSSHRC ,EC| APGREIDNatasha Arora; Verena J. Schuenemann; Günter Jäger; Alexander Peltzer; Alexander Seitz; Alexander Herbig; Michal Strouhal; Linda Grillová; Leonor Sánchez-Busó; Denise Kühnert; Kirsten I. Bos; Leyla R. Davis; Lenka Mikalová; Sylvia M. Bruisten; Peter Komericki; Patrick French; Paul R. Grant; María A. Pando; Lucía Gallo Vaulet; Marcelo Rodríguez Fermepin; Antonio Luis López Martínez; Arturo Centurion-Lara; Lorenzo Giacani; Steven J. Norris; David Šmajs; Philipp P. Bosshard; Fernando González-Candelas; Kay Nieselt; Johannes Krause; Homayoun C. Bagheri;handle: 11336/112201 , 10550/58402
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history1 . Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the secondline antibiotic azithromycin3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster. Fil: Arora, Natasha. Universitat Zurich; Suiza Fil: Schuenemann, Verena J.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania Fil: Jäger, Hünter. Eberhard Karls Universität Tübingen.; Alemania Fil: Peltzer, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Seitz, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Herbig, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Strouhal, Michal. Masaryk University; República Checa Fil: Grillová, Linda. Masaryk University; República Checa Fil: Sánchez Busó, Leonor. Universidad de Valencia; España. University of Cambridge; Reino Unido Fil: Kühnert, Denise. Universitat Zurich; Suiza Fil: Bos, Kirsten I.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania Fil: Davis Rivero, Leyla. Universitat Zurich; Suiza Fil: Mikalová, Lenka. Masaryk University; República Checa Fil: Bruisten, Sylvia. Public Health Laboratory. Department of Infectious Diseases; Países Bajos Fil: Komericki, Peter. Medical University of Graz; Austria Fil: French, Patrick. The Mortimer Market Centre ; Reino Unido Fil: Grant, Paul R.. University College London; Estados Unidos Fil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; Argentina Fil: Gallo Vaulet, Maria Lucia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Rodríguez Fermepin, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Martinez, Antonio. Hospital General Universitario de Valencia; España Fil: Lara, Arturo Centurión. University of Washington; Estados Unidos Fil: Giacani, Lorenzo. University of Washington; Estados Unidos Fil: Norris, Steven J.. UTHealth McGovern Medical School. Department of Pathology and Laboratory Medicine; Estados Unidos Fil: Smajs, David. Masaryk University; República Checa Fil: Bosshard, Philipp P.. Universitat Zurich; Suiza Fil: González Candelas, Fernando. Universidad de Valencia; España Fil: Nieselt, Kay. Eberhard Karls Universität Tübingen.; Alemania Fil: Krause, Johannes. Eberhard Karls Universität Tübingen.; Alemania Fil: Bagheri, Homayoun C.. Universitat Zurich; Suiza
Nature Microbiology arrow_drop_down Zurich Open Repository and ArchiveOther literature type . 2016Data sources: Zurich Open Repository and ArchiveRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTANature Microbiology; Recolector de Ciencia Abierta, RECOLECTAArticle . 2017 . 2016License: Springer Nature TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nmicrobiol.2016.245&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu128 citations 128 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Nature Microbiology arrow_drop_down Zurich Open Repository and ArchiveOther literature type . 2016Data sources: Zurich Open Repository and ArchiveRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTANature Microbiology; Recolector de Ciencia Abierta, RECOLECTAArticle . 2017 . 2016License: Springer Nature TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2016 AustraliaCold Spring Harbor Laboratory SSHRC, EC | APGREID, NSERCSSHRC ,EC| APGREID ,NSERCKirsten I. Bos; Alexander Herbig; Jason W. Sahl; Nicholas Waglechner; Mathieu Fourment; Stephen Forrest; Jennifer Klunk; Verena J. Schuenemann; Debi Poinar; Melanie Kuch; Brian Golding; Olivier Dutour; Paul Keim; David M. Wagner; Edward C. Holmes; Johannes Krause; Hendrik N. Poinar;eLife digest A bacterium called Yersina pestis is responsible for numerous human outbreaks of plague throughout history. It is carried by rats and other rodents and can spread to humans causing what we conventionally refer to as plague. The most notorious of these plague outbreaks – the Black Death – claimed millions of lives in Europe in the mid-14th century. Several other plague outbreaks emerged in Europe over the next 400 years. Then, there was a large gap before the plague re-emerged as threat in the 19th century and it continues to infect humans today, though on a smaller scale. Scientists have extensively studied Y. pestis to understand its origin and how it evolved to become such a deadly threat. These studies led to the assumption that the plague outbreaks of the 14–18th centuries likely originated in rodents in Asia and spread along trade routes to other parts of the world. However, it is not clear why the plague persisted in Europe for 400 years after the Black Death. Could the bacteria have gained a foothold in local rodents instead of being reintroduced from Asia each time? If it did, why did it then disappear for such a long period from the end of the 18th century? To help answer these questions, Bos, Herbig et al. sequenced the DNA of Y. pestis samples collected from the teeth of five individuals who died of plague during the last major European outbreak of plague in 1722 in Marseille, France. The DNA sequences of these bacterial samples were then compared with the DNA sequences of modern day Y. pestis and other historical samples of the bacteria. The results showed the bacteria in the Marseille outbreak likely evolved from the strain that caused the Black Death back in the 14th century. The comparisons showed that the strain isolated from the teeth is not found today, and may be extinct. This suggests that a historical reservoir for plague existed somewhere, perhaps in Asia, or perhaps in Europe itself, and was able to cause outbreaks up until the 18th century.Bos, Herbig et al.’s findings may help researchers trying to control the current outbreaks of the plague in Madagascar and other places. DOI: http://dx.doi.org/10.7554/eLife.12994.002 The 14th–18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague’s persistence and abrupt disappearance in Europe are poorly understood, but could have been due to either the presence of now-extinct plague foci in Europe itself, or successive disease introductions from other locations. Here we present five Y. pestis genomes from one of the last European outbreaks of plague, from 1722 in Marseille, France. The lineage identified has not been found in any extant Y. pestis foci sampled to date, and has its ancestry in strains obtained from victims of the 14th century Black Death. These data suggest the existence of a previously uncharacterized historical plague focus that persisted for at least three centuries. We propose that this disease source may have been responsible for the many resurgences of plague in Europe following the Black Death. DOI: http://dx.doi.org/10.7554/eLife.12994.001
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu125 citations 125 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/036509&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 FranceElsevier BV EC | APGREID, SSHRCEC| APGREID ,SSHRCMaria A. Spyrou; Rezeda I. Tukhbatova; Michal Feldman; Joanna Drath; Sacha Kacki; Julia Beltrán de Heredia; Susanne Arnold; Airat Sitdikov; Dominique Castex; Joachim Wahl; Ilgizar R. Gazimzyanov; Danis K. Nurgaliev; Alexander Herbig; Kirsten I. Bos; Johannes Krause;pmid: 27281573
Summary Ancient DNA analysis has revealed an involvement of the bacterial pathogen Yersinia pestis in several historical pandemics, including the second plague pandemic (Europe, mid-14 th century Black Death until the mid-18 th century AD). Here we present reconstructed Y. pestis genomes from plague victims of the Black Death and two subsequent historical outbreaks spanning Europe and its vicinity, namely Barcelona, Spain (1300–1420 cal AD), Bolgar City, Russia (1362–1400 AD), and Ellwangen, Germany (1485–1627 cal AD). Our results provide support for (1) a single entry of Y. pestis in Europe during the Black Death, (2) a wave of plague that traveled toward Asia to later become the source population for contemporary worldwide epidemics, and (3) the presence of an historical European plague focus involved in post-Black Death outbreaks that is now likely extinct.
Cell Host & Microbe arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu126 citations 126 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Cell Host & Microbe arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2013 Denmark, SwitzerlandAmerican Association for the Advancement of Science (AAAS) SSHRC, EC | APGREIDSSHRC ,EC| APGREIDVerena J, Schuenemann; Pushpendra, Singh; Thomas A, Mendum; Ben, Krause-Kyora; Günter, Jäger; Kirsten I, Bos; Alexander, Herbig; Christos, Economou; Andrej, Benjak; Philippe, Busso; Almut, Nebel; Jesper L, Boldsen; Anna, Kjellström; Huihai, Wu; Graham R, Stewart; G Michael, Taylor; Peter, Bauer; Oona Y-C, Lee; Houdini H T, Wu; David E, Minnikin; Gurdyal S, Besra; Katie, Tucker; Simon, Roffey; Samba O, Sow; Stewart T, Cole; Kay, Nieselt; Johannes, Krause;pmid: 23765279
Leprosy: Ancient and Modern In medieval Europe, leprosy was greatly feared: Sufferers had to wear bells and were shunned and kept isolated from society. Although leprosy largely disappeared from Europe in the 16th century, elsewhere in the world almost a quarter of a million cases are still reported annually, despite the availability of effective drugs. Schuenemann et al. (p. 179 , published online 13 June; see the 14 June News story by Gibbons , p. 1278 ) probed the origins of leprosy bacilli by using a genomic capture-based approach on DNA obtained from skeletal remains from the 10th to 14th centuries. Because the unique mycolic acids of this mycobacterium protect its DNA, for one Danish sample over 100-fold, coverage of the genome was possible. Sequencing suggests a link between the middle-eastern and medieval European strains, which falls in line with social historical expectations that the returning expeditionary forces of antiquity originally spread the pathogen. Subsequently, Europeans took the bacterium westward to the Americas. Overall, ancient and modern strains remain remarkably similar, with no apparent loss of virulence genes, indicating it was most probably improvements in social conditions that led to leprosy's demise in Europe.
University of Southe... arrow_drop_down University of Southern Denmark Research OutputArticle . 2013Data sources: University of Southern Denmark Research OutputInfoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsScienceArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/science.1238286&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu301 citations 301 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert University of Southe... arrow_drop_down University of Southern Denmark Research OutputArticle . 2013Data sources: University of Southern Denmark Research OutputInfoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsScienceArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/science.1238286&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Spain, Switzerland, ArgentinaSpringer Science and Business Media LLC SSHRC, EC | APGREIDSSHRC ,EC| APGREIDNatasha Arora; Verena J. Schuenemann; Günter Jäger; Alexander Peltzer; Alexander Seitz; Alexander Herbig; Michal Strouhal; Linda Grillová; Leonor Sánchez-Busó; Denise Kühnert; Kirsten I. Bos; Leyla R. Davis; Lenka Mikalová; Sylvia M. Bruisten; Peter Komericki; Patrick French; Paul R. Grant; María A. Pando; Lucía Gallo Vaulet; Marcelo Rodríguez Fermepin; Antonio Luis López Martínez; Arturo Centurion-Lara; Lorenzo Giacani; Steven J. Norris; David Šmajs; Philipp P. Bosshard; Fernando González-Candelas; Kay Nieselt; Johannes Krause; Homayoun C. Bagheri;handle: 11336/112201 , 10550/58402
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history1 . Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the secondline antibiotic azithromycin3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster. Fil: Arora, Natasha. Universitat Zurich; Suiza Fil: Schuenemann, Verena J.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania Fil: Jäger, Hünter. Eberhard Karls Universität Tübingen.; Alemania Fil: Peltzer, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Seitz, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Herbig, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Strouhal, Michal. Masaryk University; República Checa Fil: Grillová, Linda. Masaryk University; República Checa Fil: Sánchez Busó, Leonor. Universidad de Valencia; España. University of Cambridge; Reino Unido Fil: Kühnert, Denise. Universitat Zurich; Suiza Fil: Bos, Kirsten I.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania Fil: Davis Rivero, Leyla. Universitat Zurich; Suiza Fil: Mikalová, Lenka. Masaryk University; República Checa Fil: Bruisten, Sylvia. Public Health Laboratory. Department of Infectious Diseases; Países Bajos Fil: Komericki, Peter. Medical University of Graz; Austria Fil: French, Patrick. The Mortimer Market Centre ; Reino Unido Fil: Grant, Paul R.. University College London; Estados Unidos Fil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; Argentina Fil: Gallo Vaulet, Maria Lucia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Rodríguez Fermepin, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Martinez, Antonio. Hospital General Universitario de Valencia; España Fil: Lara, Arturo Centurión. University of Washington; Estados Unidos Fil: Giacani, Lorenzo. University of Washington; Estados Unidos Fil: Norris, Steven J.. UTHealth McGovern Medical School. Department of Pathology and Laboratory Medicine; Estados Unidos Fil: Smajs, David. Masaryk University; República Checa Fil: Bosshard, Philipp P.. Universitat Zurich; Suiza Fil: González Candelas, Fernando. Universidad de Valencia; España Fil: Nieselt, Kay. Eberhard Karls Universität Tübingen.; Alemania Fil: Krause, Johannes. Eberhard Karls Universität Tübingen.; Alemania Fil: Bagheri, Homayoun C.. Universitat Zurich; Suiza
Nature Microbiology arrow_drop_down Zurich Open Repository and ArchiveOther literature type . 2016Data sources: Zurich Open Repository and ArchiveRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTANature Microbiology; Recolector de Ciencia Abierta, RECOLECTAArticle . 2017 . 2016License: Springer Nature TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nmicrobiol.2016.245&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu128 citations 128 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Nature Microbiology arrow_drop_down Zurich Open Repository and ArchiveOther literature type . 2016Data sources: Zurich Open Repository and ArchiveRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTANature Microbiology; Recolector de Ciencia Abierta, RECOLECTAArticle . 2017 . 2016License: Springer Nature TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nmicrobiol.2016.245&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2016 AustraliaCold Spring Harbor Laboratory SSHRC, EC | APGREID, NSERCSSHRC ,EC| APGREID ,NSERCKirsten I. Bos; Alexander Herbig; Jason W. Sahl; Nicholas Waglechner; Mathieu Fourment; Stephen Forrest; Jennifer Klunk; Verena J. Schuenemann; Debi Poinar; Melanie Kuch; Brian Golding; Olivier Dutour; Paul Keim; David M. Wagner; Edward C. Holmes; Johannes Krause; Hendrik N. Poinar;eLife digest A bacterium called Yersina pestis is responsible for numerous human outbreaks of plague throughout history. It is carried by rats and other rodents and can spread to humans causing what we conventionally refer to as plague. The most notorious of these plague outbreaks – the Black Death – claimed millions of lives in Europe in the mid-14th century. Several other plague outbreaks emerged in Europe over the next 400 years. Then, there was a large gap before the plague re-emerged as threat in the 19th century and it continues to infect humans today, though on a smaller scale. Scientists have extensively studied Y. pestis to understand its origin and how it evolved to become such a deadly threat. These studies led to the assumption that the plague outbreaks of the 14–18th centuries likely originated in rodents in Asia and spread along trade routes to other parts of the world. However, it is not clear why the plague persisted in Europe for 400 years after the Black Death. Could the bacteria have gained a foothold in local rodents instead of being reintroduced from Asia each time? If it did, why did it then disappear for such a long period from the end of the 18th century? To help answer these questions, Bos, Herbig et al. sequenced the DNA of Y. pestis samples collected from the teeth of five individuals who died of plague during the last major European outbreak of plague in 1722 in Marseille, France. The DNA sequences of these bacterial samples were then compared with the DNA sequences of modern day Y. pestis and other historical samples of the bacteria. The results showed the bacteria in the Marseille outbreak likely evolved from the strain that caused the Black Death back in the 14th century. The comparisons showed that the strain isolated from the teeth is not found today, and may be extinct. This suggests that a historical reservoir for plague existed somewhere, perhaps in Asia, or perhaps in Europe itself, and was able to cause outbreaks up until the 18th century.Bos, Herbig et al.’s findings may help researchers trying to control the current outbreaks of the plague in Madagascar and other places. DOI: http://dx.doi.org/10.7554/eLife.12994.002 The 14th–18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague’s persistence and abrupt disappearance in Europe are poorly understood, but could have been due to either the presence of now-extinct plague foci in Europe itself, or successive disease introductions from other locations. Here we present five Y. pestis genomes from one of the last European outbreaks of plague, from 1722 in Marseille, France. The lineage identified has not been found in any extant Y. pestis foci sampled to date, and has its ancestry in strains obtained from victims of the 14th century Black Death. These data suggest the existence of a previously uncharacterized historical plague focus that persisted for at least three centuries. We propose that this disease source may have been responsible for the many resurgences of plague in Europe following the Black Death. DOI: http://dx.doi.org/10.7554/eLife.12994.001
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/036509&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu125 citations 125 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/036509&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 FranceElsevier BV EC | APGREID, SSHRCEC| APGREID ,SSHRCMaria A. Spyrou; Rezeda I. Tukhbatova; Michal Feldman; Joanna Drath; Sacha Kacki; Julia Beltrán de Heredia; Susanne Arnold; Airat Sitdikov; Dominique Castex; Joachim Wahl; Ilgizar R. Gazimzyanov; Danis K. Nurgaliev; Alexander Herbig; Kirsten I. Bos; Johannes Krause;pmid: 27281573
Summary Ancient DNA analysis has revealed an involvement of the bacterial pathogen Yersinia pestis in several historical pandemics, including the second plague pandemic (Europe, mid-14 th century Black Death until the mid-18 th century AD). Here we present reconstructed Y. pestis genomes from plague victims of the Black Death and two subsequent historical outbreaks spanning Europe and its vicinity, namely Barcelona, Spain (1300–1420 cal AD), Bolgar City, Russia (1362–1400 AD), and Ellwangen, Germany (1485–1627 cal AD). Our results provide support for (1) a single entry of Y. pestis in Europe during the Black Death, (2) a wave of plague that traveled toward Asia to later become the source population for contemporary worldwide epidemics, and (3) the presence of an historical European plague focus involved in post-Black Death outbreaks that is now likely extinct.
Cell Host & Microbe arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chom.2016.05.012&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu126 citations 126 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Cell Host & Microbe arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.chom.2016.05.012&type=result"></script>'); --> </script>
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