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The data presented here and in the SI are made available in tabulated form as an electronic supplement to this article.

U-2 OS cells were seeded onto 8-well LabTek II imaging chambers (ThermoFisher) in complete media with 1 μg/mL tetracycline and grown for 24 h to allow expression of GFP-tagged protein. Before imaging, the media was replaced with 200 μL of phenol red-free DMEM supplemented with 10% FBS, 1 mM sodium pyruvate, and 1× Glutamax (all Life Technologies). Images stacks were acquired on an imaging system (DeltaVision Elite, GE Healthcare). Cells were imaged at 37°C in 5% CO2 at 60×, 1.42NA, with 2×2 binning. Image Z-stacks of 24 μm were aquired at 2 μm intervals over 2 - 5 min as indicated. 20 s after the start of data acquisition, 100 μL of warm media containing 1.5 μM JQ1 was added to each cell chamber manually for a final concentration of 500 nM. The exposure time was 10 ms at 32% for GFP-tagged bait protein. Z-stacks were collected, deconvolved using softWoRx (v5.0, Applied Precision) and displayed as maximum intensity projections (pixel size 0.1075 μm). Images were cropped in ImageJ (National Institutes of Health). Supplemental Movie S1 – Flp-In T-REx U-2 OS cells expressing GFP-tagged BRD2 treated with 500 nM JQ1 for 2 min. Supplemental Movie S2 – Flp-In T-REx U-2 OS cells expressing GFP-tagged BRD3 (WT construct) treated with 500 nM JQ1 for 2 min. Supplemental Movie S3 – Flp-In T-REx U-2 OS cells expressing GFP-tagged BRD4 treated with 500 nM JQ1 for 2 min. Supplemental Movie S4 – Flp-In T-REx U-2 OS cells expressing GFP-tagged BRD3 BD1mut treated with 500 nM JQ1 for 2 min. Supplemental Movie S5 – Flp-In T-REx U-2 OS cells expressing GFP-tagged BRD3 BD2mut treated with 500 nM JQ1 for 2 min. Supplemental Movie S6 – Flp-In T-REx U-2 OS cells expressing GFP-tagged BRD3 (BD1:2)mut treated with 500 nM JQ1 for 2 min.

Human ratings of hyponymy for 2754 English compound words, The stimuli were selected from the Large Database of English Compounds (LADEC Gagné, Spalding, & Schmidtke, 2019) which is a database of over 8000 English closed (i.e., unspaced) compounds along with various psycholinguistic properties including several measures of semantic transparency (based on human ratings and corpus-based measures of association). In total, 2574 compounds were selected were divided into nine lists ranging from 200 to 354 items. Each list was used for one experiment for a total of nine experiments collected across a 2 year period and was seen by 97 to 121 participants. In total, 936 native speakers of English from the University of Alberta participated in the study. The responses were aggregated to obtain the percentage of participants responding yes for each item.

Global trade (physical trade balances) with cereals, oil crops and meat from 1850/70 to 2016 by world regions; Global sown area, production and yield per unit are of wheat; Global cereal export per capita of global population.

Table S1A. All hydrogen deuterium exchange (HDX) peptide data for experiments examining the global exchange of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. In the Raw Data column, the two time points (0.3s and full) are labelled, and the relative level of HDX is coloured according to the amount of deuterium incorporated, on a blue to red continuum. The data listed for the 0.3s time point are the average of three independent experiments, with SD shown next to all HDX values. In the Normalized to Full Deuteration column, the 0.3s data has been normalised to the full deuteration measurements with the exception of those data (surrounded by black lines) where the full deuteration measurement was lower than 20% deuterium incorporation. The third column denotes the corresponding peptide centroid. Table S1B. All HDX peptide data for experiments examining the complex dynamics of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. The two columns represent each state examined (+/- PI4KIIIA) and contain the data for five time points. The data listed are the average of three independent experiments, with SD shown next to all HDX values. Table S1C. All HDX peptide data for experiments examining the dynamics of inhibitor specificity of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. The three columns represent each state examined (+/- inhibitor) and contain the data for four time points. The data listed are the average of three independent experiments, with SD shown next to all HDX values.

Electronic Supplementary Material including: - Zircon U-Pb/Hf/O analyses of unknowns and calibration+validation material - Supplementary diagrams for data quality check - CL+BSE images of analyzed grains

Data set includes: -Python code for all Experiments (Executed via Psychopy) -Raw data in the Collins and Milliken - Raw Data.zip file -Compiled processed data in Excel format for all experiments -Compiled processed data sets and output for SPSS for Experiments 3a, 3b, 4a, and 4b

This excel file contains SO4 concentrations as well as SO4 stable isotopes values (delta18O-SO4 and delta 34S-SO4) in precipitation and soil water collected with lysimeters at different depths (humus, top B and low B horizons) at a forest catchment in southern Quebec, Canada.

Original images associated with MOLECULAR-CELL-D-16-01448R2.

Flow cytometric analyses of day 4 CD235a/Aldefluor and day20 MLC2V/CTNT expression of HES2 hESC (Figure S8) and MSC-iPS1 hiPSC lines (Figure S9)