The spectrum of left ventricular function in systemic human sepsis remains incompletely characterized. We studied 20 septic patients early in the course of their disease using standard hemodynamic monitoring techniques as well as radionuclide (RN) angiography. No patien...

We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of recombinant tissue plasminogen activator (rtPA) administered intravenously and...

Background Obesity affects lung function and gas exchange and imposes mechanical ventilatory limitations during exercise that could disrupt the predictability of Pa CO 2 from end-tidal P CO 2 (P ETCO 2 ), an important clinical tool for assessing gas exchange efficiency ...

Objective To study the relationship of resting pulmonary function to maximal exercise power output (Wmax) in obstructive lung disease (OLD). Setting University Hospital Pulmonary Function Laboratory. Subjects Twenty-five patients with OLD (6 with asthma and 19 with COPD...

Study objectives: To determine if intrapleural administration of methylprednisolone acetate (MA) after therapeutic thoracentesis for symptomatic malignant pleural effusion improved time to repeat thoracentesis for symptom control, quality of life (QOL), and dyspnea. Des...

Airway smooth muscle (ASM) mass appears to be increased in the bronchi of patients with chronic severe asthma. Although the precise mechanisms that induce these changes are unknown, increases in ASM mass are caused, in part, by ASM cell proliferation. After allergen ch...

COPD is a common disease with substantial associated morbidity and mortality. Patients with COPD usually have a progression of airflow obstruction that is not fully reversible and can lead to a history of progressively worsening breathlessness, affecting daily activitie...