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description Publicationkeyboard_double_arrow_right Article , Other literature type 2018 Ireland, Switzerland, France, United Kingdom, France, Italy, France, United Kingdom, Sweden, United Kingdom, Singapore, Italy, Italy, United Kingdom, United Kingdom, Finland, Netherlands, CroatiaSpringer Science and Business Media LLC EC | PhenoMeNal, NIH | Transition of Care in CKD..., UKRI | MRC-PHE Centre for Enviro... +23 projectsEC| PhenoMeNal ,NIH| Transition of Care in CKD (TC-CKD) ,UKRI| MRC-PHE Centre for Environment and Health ,NIH| Study of coding variants in human obesity and their functional characterization using human iPSC-derived cellular models ,NIH| Pharmacogenomics of risk factors and therapies outcomes for kidney disease ,UKRI| Aetiology of type 2 diabetes and obesity and related metabolic disorders ,NIH| Diverse ancestry biobank to map biomedical traits and elucidate health disparitie ,WT| Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics. ,NIH| Identifying Genes for Type 2 Diabetes: FUSION ,NIH| Dysmetabolism of Chronic Kidney Disease and Vascular Health ,NIH| Racial and Cardiovascular Risk Factor Anomalies in CKD ,UKRI| MICA: Ancestry and biological Informative Markers for stratification of HYpertension: The AIM HY study ,UKRI| Automated manufacturing cost estimator and supply chain management portal ,NIH| COGENT consortium meta-analysis of blood pressure in African ancestry cohorts ,SNSF| Blood pressure and the kidney: interface between genes and environment ,FCT| LA 1 ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,EC| MOvE-ECG ,NIH| Leveraging ancestral diversity to map adiposity loci in Hispanics ,EC| CVGENES-AT-TARGET ,EC| ePerMed ,NIH| Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer ,UKRI| MICA: Medical Bioinformatics: Data-Driven Discovery for Personalised Medicine ,NIH| Search for obesity-associated genes with protective effects on metabolic health ,UKRI| MICA: UK MEDical BIOinformatics partnership - aggregation, integration, visualisation and analysis of large, complex data (UK MED-BIO). ,CIHREvangelos Evangelou; Helen R. Warren; Borbala Mifsud; Raha Pazoki; Niki Dimou; Claudia P. Cabrera; Ibrahim Karaman; Marina Evangelou; K. Witkowska; Evan Tzanis; Jacklyn N. Hellwege; Ayush Giri; Digna R. Velez Edwards; Yan V. Sun; Peter W.F. Wilson; Philip S. Tsao; Csaba P. Kovesdy; Tõnu Esko; Lili Milani; Peter Almgren; Thibaud Boutin; Stéphanie Debette; Jun Ding; Franco Giulianini; Elizabeth G. Holliday; Anne U. Jackson; Ruifang Li-Gao; Wei-Yu Lin; Jian'an Luan; Massimo Mangino; Bram P. Prins; Yong Qian; Muralidharan Sargurupremraj; Nabi Shah; Sébastien Thériault; Niek Verweij; Sara M. Willems; Philippe Amouyel; Renée de Mutsert; Alex S. F. Doney; Martin Farrall; Cristina Menni; Raymond Noordam; Neil Poulter; Alice Stanton; Simon Thom; Najaf Amin; Dan E. Arking; Kristin L. Ayers; Joshua C. Bis; Murielle Bochud; Michael Boehnke; Eric Boerwinkle; Dorret I. Boomsma; Erwin P. Bottinger; Peter S. Braund; Marco Brumat; Archie Campbell; Harry Campbell; John C. Chambers; Ganesh Chauhan; Marina Ciullo; Massimiliano Cocca; Francis S. Collins; Heather J. Cordell; Martin H. de Borst; Eco J. C. de Geus; Ian J. Deary; Joris Deelen; Fabiola Del Greco M; Marcus Dörr; Roberto Elosua; Stefan Enroth; A. Mesut Erzurumluoglu; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Christian Gieger; Giorgia Girotto; Anuj Goel; Alan J. Gow; Vilmundur Gudnason; Xiuqing Guo; Anders Hamsten; Catharina A. Hartman; Aki S. Havulinna; Andrew A. Hicks; Edith Hofer; Albert Hofman; Jouke-Jan Hottenga; Jennifer E. Huffman; Shih-Jen Hwang; Alan James; Rick Jansen; Marjo-Riitta Järvelin; Roby Joehanes; Åsa Johansson; Andrew D. Johnson; Peter K. Joshi; Pekka Jousilahti; J. Wouter Jukema; Mika Kähönen; Sekar Kathiresan; Bernard Keavney; Kay-Tee Khaw; Paul Knekt; Joanne Knight; Ivana Kolcic; Jaspal S. Kooner; Seppo Koskinen; Kati Kristiansson; Zoltán Kutalik; Maris Laan; Lenore J. Launer; Benjamin Lehne; Terho Lehtimäki; David C. Liewald; Li Lin; Cecilia M. Lindgren; Ruth J. F. Loos; Lorna M. Lopez; Yingchang Lu; Leo-Pekka Lyytikäinen; Anubha Mahajan; Chrysovalanto Mamasoula; Jaume Marrugat; Yuri Milaneschi; Anna Morgan; Andrew P. Morris; Teemu J. Niiranen; Ilja M. Nolte; Teresa Nutile; Albertine J. Oldehinkel; Ben A. Oostra; Paul F. O'Reilly; Elin Org; Sandosh Padmanabhan; Aarno Palotie; Brenda W.J.H. Penninx; Markus Perola; Annette Peters; Ozren Polasek; Peter P. Pramstaller; Quang Tri Nguyen; Olli T. Raitakari; Meixia Ren; Rainer Rettig; Paul M. Ridker; Janina S. Ried; Harriëtte Riese; Samuli Ripatti; Antonietta Robino; Lynda M. Rose; Jerome I. Rotter; Igor Rudan; Yasaman Saba; Cinzia Sala; Veikko Salomaa; Nilesh J. Samani; Helena Schmidt; Nick Shrine; David S. Siscovick; Albert V. Smith; Harold Snieder; Siim Sõber; John M. Starr; David J. Stott; David P. Strachan; Rona J. Strawbridge; Johan Sundström; Morris A. Swertz; Alexander Teumer; Martin D. Tobin; Maciej Tomaszewski; Daniela Toniolo; Michela Traglia; Stella Trompet; Christophe Tzourio; André G. Uitterlinden; Ahmad Vaez; Peter J. van der Most; Cornelia M. van Duijn; Anne-Claire Vergnaud; Germaine C. Verwoert; Veronique Vitart; Uwe Völker; Peter Vollenweider; Dragana Vuckovic; Gonneke Willemsen; James F. Wilson; Alan F. Wright; Tatijana Zemunik; John Attia; Adam S. Butterworth; Daniel I. Chasman; David Conen; Francesco Cucca; John Danesh; Caroline Hayward; Joanna M. M. Howson; Edward G. Lakatta; Claudia Langenberg; Olle Melander; Dennis O. Mook-Kanamori; Colin N. A. Palmer; Lorenz Risch; Rodney J. Scott; Peter S. Sever; Pim van der Harst; Nicholas J. Wareham; Eleftheria Zeggini; Daniel Levy; Patricia B. Munroe; Christopher Newton-Cheh; Morris J. Brown; Andres Metspalu; Todd L. Edwards; Bruce M. Psaty; Ioanna Tzoulaki; Michael R. Barnes; Louise V. Wain; Paul Elliott; Mark J. Caulfield;handle: 1887/79934 , 11370/1a3fe681-ae6c-4516-98e9-7e7b01c6ad6f , 1871.1/796b34b1-6752-4452-a574-7864fbeb8b3c , 21.11116/0000-000B-48A1-E , 1765/110487 , 11368/2929326 , 20.500.11820/ccd0fd55-bf95-4b13-9faf-48f507e3a62c
pmc: PMC6284793
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore)
NARCIS arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryNature Genetics; Oxford University Research Archive; Lancaster EPrints; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2018License: Springer TDMMaynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2018HELDA - Digital Repository of the University of HelsinkiArticle . 2018Data sources: HELDA - Digital Repository of the University of HelsinkiSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryPublikationer från Uppsala UniversitetArticle . 2018Data sources: Publikationer från Uppsala UniversitetNature Genetics; NARCISArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-018-0205-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu878 citations 878 popularity Top 0.01% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 69visibility views 69 download downloads 436 Powered bymore_vert NARCIS arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryNature Genetics; Oxford University Research Archive; Lancaster EPrints; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2018License: Springer TDMMaynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2018HELDA - Digital Repository of the University of HelsinkiArticle . 2018Data sources: HELDA - Digital Repository of the University of HelsinkiSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryPublikationer från Uppsala UniversitetArticle . 2018Data sources: Publikationer från Uppsala UniversitetNature Genetics; NARCISArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-018-0205-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2018 Ireland, Switzerland, France, United Kingdom, France, Italy, France, United Kingdom, Sweden, United Kingdom, Singapore, Italy, Italy, United Kingdom, United Kingdom, Finland, Netherlands, CroatiaSpringer Science and Business Media LLC EC | PhenoMeNal, NIH | Transition of Care in CKD..., UKRI | MRC-PHE Centre for Enviro... +23 projectsEC| PhenoMeNal ,NIH| Transition of Care in CKD (TC-CKD) ,UKRI| MRC-PHE Centre for Environment and Health ,NIH| Study of coding variants in human obesity and their functional characterization using human iPSC-derived cellular models ,NIH| Pharmacogenomics of risk factors and therapies outcomes for kidney disease ,UKRI| Aetiology of type 2 diabetes and obesity and related metabolic disorders ,NIH| Diverse ancestry biobank to map biomedical traits and elucidate health disparitie ,WT| Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics. ,NIH| Identifying Genes for Type 2 Diabetes: FUSION ,NIH| Dysmetabolism of Chronic Kidney Disease and Vascular Health ,NIH| Racial and Cardiovascular Risk Factor Anomalies in CKD ,UKRI| MICA: Ancestry and biological Informative Markers for stratification of HYpertension: The AIM HY study ,UKRI| Automated manufacturing cost estimator and supply chain management portal ,NIH| COGENT consortium meta-analysis of blood pressure in African ancestry cohorts ,SNSF| Blood pressure and the kidney: interface between genes and environment ,FCT| LA 1 ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,EC| MOvE-ECG ,NIH| Leveraging ancestral diversity to map adiposity loci in Hispanics ,EC| CVGENES-AT-TARGET ,EC| ePerMed ,NIH| Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer ,UKRI| MICA: Medical Bioinformatics: Data-Driven Discovery for Personalised Medicine ,NIH| Search for obesity-associated genes with protective effects on metabolic health ,UKRI| MICA: UK MEDical BIOinformatics partnership - aggregation, integration, visualisation and analysis of large, complex data (UK MED-BIO). ,CIHREvangelos Evangelou; Helen R. Warren; Borbala Mifsud; Raha Pazoki; Niki Dimou; Claudia P. Cabrera; Ibrahim Karaman; Marina Evangelou; K. Witkowska; Evan Tzanis; Jacklyn N. Hellwege; Ayush Giri; Digna R. Velez Edwards; Yan V. Sun; Peter W.F. Wilson; Philip S. Tsao; Csaba P. Kovesdy; Tõnu Esko; Lili Milani; Peter Almgren; Thibaud Boutin; Stéphanie Debette; Jun Ding; Franco Giulianini; Elizabeth G. Holliday; Anne U. Jackson; Ruifang Li-Gao; Wei-Yu Lin; Jian'an Luan; Massimo Mangino; Bram P. Prins; Yong Qian; Muralidharan Sargurupremraj; Nabi Shah; Sébastien Thériault; Niek Verweij; Sara M. Willems; Philippe Amouyel; Renée de Mutsert; Alex S. F. Doney; Martin Farrall; Cristina Menni; Raymond Noordam; Neil Poulter; Alice Stanton; Simon Thom; Najaf Amin; Dan E. Arking; Kristin L. Ayers; Joshua C. Bis; Murielle Bochud; Michael Boehnke; Eric Boerwinkle; Dorret I. Boomsma; Erwin P. Bottinger; Peter S. Braund; Marco Brumat; Archie Campbell; Harry Campbell; John C. Chambers; Ganesh Chauhan; Marina Ciullo; Massimiliano Cocca; Francis S. Collins; Heather J. Cordell; Martin H. de Borst; Eco J. C. de Geus; Ian J. Deary; Joris Deelen; Fabiola Del Greco M; Marcus Dörr; Roberto Elosua; Stefan Enroth; A. Mesut Erzurumluoglu; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Christian Gieger; Giorgia Girotto; Anuj Goel; Alan J. Gow; Vilmundur Gudnason; Xiuqing Guo; Anders Hamsten; Catharina A. Hartman; Aki S. Havulinna; Andrew A. Hicks; Edith Hofer; Albert Hofman; Jouke-Jan Hottenga; Jennifer E. Huffman; Shih-Jen Hwang; Alan James; Rick Jansen; Marjo-Riitta Järvelin; Roby Joehanes; Åsa Johansson; Andrew D. Johnson; Peter K. Joshi; Pekka Jousilahti; J. Wouter Jukema; Mika Kähönen; Sekar Kathiresan; Bernard Keavney; Kay-Tee Khaw; Paul Knekt; Joanne Knight; Ivana Kolcic; Jaspal S. Kooner; Seppo Koskinen; Kati Kristiansson; Zoltán Kutalik; Maris Laan; Lenore J. Launer; Benjamin Lehne; Terho Lehtimäki; David C. Liewald; Li Lin; Cecilia M. Lindgren; Ruth J. F. Loos; Lorna M. Lopez; Yingchang Lu; Leo-Pekka Lyytikäinen; Anubha Mahajan; Chrysovalanto Mamasoula; Jaume Marrugat; Yuri Milaneschi; Anna Morgan; Andrew P. Morris; Teemu J. Niiranen; Ilja M. Nolte; Teresa Nutile; Albertine J. Oldehinkel; Ben A. Oostra; Paul F. O'Reilly; Elin Org; Sandosh Padmanabhan; Aarno Palotie; Brenda W.J.H. Penninx; Markus Perola; Annette Peters; Ozren Polasek; Peter P. Pramstaller; Quang Tri Nguyen; Olli T. Raitakari; Meixia Ren; Rainer Rettig; Paul M. Ridker; Janina S. Ried; Harriëtte Riese; Samuli Ripatti; Antonietta Robino; Lynda M. Rose; Jerome I. Rotter; Igor Rudan; Yasaman Saba; Cinzia Sala; Veikko Salomaa; Nilesh J. Samani; Helena Schmidt; Nick Shrine; David S. Siscovick; Albert V. Smith; Harold Snieder; Siim Sõber; John M. Starr; David J. Stott; David P. Strachan; Rona J. Strawbridge; Johan Sundström; Morris A. Swertz; Alexander Teumer; Martin D. Tobin; Maciej Tomaszewski; Daniela Toniolo; Michela Traglia; Stella Trompet; Christophe Tzourio; André G. Uitterlinden; Ahmad Vaez; Peter J. van der Most; Cornelia M. van Duijn; Anne-Claire Vergnaud; Germaine C. Verwoert; Veronique Vitart; Uwe Völker; Peter Vollenweider; Dragana Vuckovic; Gonneke Willemsen; James F. Wilson; Alan F. Wright; Tatijana Zemunik; John Attia; Adam S. Butterworth; Daniel I. Chasman; David Conen; Francesco Cucca; John Danesh; Caroline Hayward; Joanna M. M. Howson; Edward G. Lakatta; Claudia Langenberg; Olle Melander; Dennis O. Mook-Kanamori; Colin N. A. Palmer; Lorenz Risch; Rodney J. Scott; Peter S. Sever; Pim van der Harst; Nicholas J. Wareham; Eleftheria Zeggini; Daniel Levy; Patricia B. Munroe; Christopher Newton-Cheh; Morris J. Brown; Andres Metspalu; Todd L. Edwards; Bruce M. Psaty; Ioanna Tzoulaki; Michael R. Barnes; Louise V. Wain; Paul Elliott; Mark J. Caulfield;handle: 1887/79934 , 11370/1a3fe681-ae6c-4516-98e9-7e7b01c6ad6f , 1871.1/796b34b1-6752-4452-a574-7864fbeb8b3c , 21.11116/0000-000B-48A1-E , 1765/110487 , 11368/2929326 , 20.500.11820/ccd0fd55-bf95-4b13-9faf-48f507e3a62c
pmc: PMC6284793
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore)
NARCIS arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryNature Genetics; Oxford University Research Archive; Lancaster EPrints; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2018License: Springer TDMMaynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2018HELDA - Digital Repository of the University of HelsinkiArticle . 2018Data sources: HELDA - Digital Repository of the University of HelsinkiSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryPublikationer från Uppsala UniversitetArticle . 2018Data sources: Publikationer från Uppsala UniversitetNature Genetics; NARCISArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-018-0205-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu878 citations 878 popularity Top 0.01% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 69visibility views 69 download downloads 436 Powered bymore_vert NARCIS arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryNature Genetics; Oxford University Research Archive; Lancaster EPrints; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2018License: Springer TDMMaynooth University ePrints & eTheses ArchiveArticle . 2018Data sources: Maynooth University ePrints & eTheses ArchiveLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2018HELDA - Digital Repository of the University of HelsinkiArticle . 2018Data sources: HELDA - Digital Repository of the University of HelsinkiSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryPublikationer från Uppsala UniversitetArticle . 2018Data sources: Publikationer från Uppsala UniversitetNature Genetics; NARCISArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-018-0205-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu