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  • Closed Access
    Authors: 
    George Mylonakis; Costis Syngros; George Gazetas; Takashi Tazoh;
    Publisher: Wiley

    An investigation is presented of the collapse of a 630 m segment (Fukae section) of the elevated Hanshin Expressway during the 1995 Kobe earthquake. The earthquake has, from a geotechnical viewpoint, been associated with extensive liquefactions, lateral soil spreading, and damage to waterfront structures. Evidence is presented that soil–structure interaction (SSI) in non-liquefied ground played a detrimental role in the seismic performance of this major structure. The bridge consisted of single circular concrete piers monolithically connected to a concrete deck, founded on groups of 17 piles in layers of loose to dense sands and moderate to stiff clays. There were 18 spans in total, all of which suffered a spectacular pier failure and transverse overturning. Several factors associated with poor structural design have already been identified. The scope of this work is to extend the previous studies by investigating the role of soil in the collapse. The following issues are examined: (1) seismological and geotechnical information pertaining to the site; (2) free-field soil response; (3) response of foundation-superstructure system; (4) evaluation of results against earlier studies that did not consider SSI. Results indicate that the role of soil in the collapse was multiple: First, it modified the bedrock motion so that the frequency content of the resulting surface motion became disadvantageous for the particular structure. Second, the compliance of soil and foundation altered the vibrational characteristics of the bridge and moved it to a region of stronger response. Third, the compliance of the foundation increased the participation of the fundamental mode of the structure, inducing stronger response. It is shown that the increase in inelastic seismic demand in the piers may have exceeded 100% in comparison with piers fixed at the base. These conclusions contradict a widespread view of an always-beneficial role of seismic SSI. Copyright © 2005 John Wiley & Sons, Ltd.

  • Open Access
    Authors: 
    Morad Aaboud; Alexander Kupco; Stefan Schmitt; Ahmed Bassalat; Matej Melo; Marjorie Shapiro; Grigore Tarna; Till Eifert; Maximiliano Sioli; Nello Bruscino; +816 more
    Publisher: American Physical Society (APS)
    Project: NSERC

    A measurement of the associated production of a top-quark pair (tt) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb-1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The ttZ and ttW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σttZ=0.95±0.08stat±0.10syst pb and σttW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the ttZ cross section is used to set constraints on effective field theory operators which modify the ttZ vertex.

  • Open Access
    Authors: 
    Schellenberg, D; Armstrong Schellenberg, J R M; Mushi, A; Savigny de, D; Mgalula, L; Mbuya, C; Victoria, C.G.;
    Country: Tanzania (United Republic of)

    Objective was to document the prevalence, age-distribution, and risk factors for anaemia in Tanzanian children less than 5 years old,thereby assisting in the development of effective strategies for controlling anaemia. Cluster sampling was used to identify 2417 households at random from four contiguous districts in south-eastern United Republic of Tanzania in mid-1999. Data on various social and medical parameters were collected and analysed. Blood haemoglobin concentrations (Hb) were available for 1979 of the 2131 (93%) children identified and ranged from 1.7 to 18.6 g/dl. Overall, 87% (1722) of children had an Hb <11 g/dl, 39% (775) had an Hb <8 g/dl and 3% (65) had an Hb <5 g/dl. The highest prevalence of anaemia of all three levels was in children aged 6–11 months, of whom 10% (22/226) had an Hb <5 g/dl. However, the prevalence of anaemia was already high in children aged 1–5 months (85% had an Hb <11 g/dl, 42% had an Hb <8 g/dl, and 6% had an Hb <5 g/dl). Anaemia was usually asymptomatic and when symptoms arose they were nonspecific and rarely identified as a serious illness by the care provider. A recent history of treatment with antimalarials and iron was rare. Compliance with vaccinations delivered through the Expanded Programme of Immunization (EPI) was 82% and was notassociated with risk of anaemia. Anaemia is extremely common in south-eastern United Republic of Tanzania, even in very young infants. Further implementation of the Integrated Management of Childhood Illness algorithm should improve the case management of anaemia. However, the asymptomatic nature of most episodes of anaemia highlights the need for preventive strategies. The EPI has good coverage of the target population and it may be an appropriate channel for delivering tools for controlling anaemia and malaria.

  • Closed Access
    Authors: 
    Hongju Cheng; Naixue Xiong; Athanasios V. Vasilakos; Laurence T. Yang; Guolong Chen; Xiaofang Zhuang;
    Publisher: Elsevier BV

    The wireless mesh network is a new emerging broadband technology providing the last-mile Internet access for mobile users by exploiting the advantage of multiple radios and multiple channels. The throughput improvement of the network relies heavily on the utilizing the orthogonal channels. However, an improper channel assignment scheme may lead to network partition or links failure. In this paper we consider the assignment strategy with topology preservation by organizing the mesh nodes with available channels, and aim at minimizing the co-channel interference in the network. The channel assignment with the topology preservation is proved to be NP-hard and to find the optimized solution in polynomial time is impossible. We have formulated a channel assignment algorithm named as DPSO-CA which is based on the discrete particle swarm optimization and can be used to find the approximate optimized solution. We have shown that our algorithm can be easily extended to the case with uneven traffic load in the network. The impact of radio utilization during the channel assignment process is discussed too. Extensive simulation results have demonstrated that our algorithm has good performance in both dense and sparse networks compared with related works.

  • Open Access
    Authors: 
    T. Aaltonen; Ronen Alon; A. Anastassov; Giorgio Apollinari; Tetsuo Arisawa; A. Artikov; J. Asaadi; A. Barbaro-Galtieri; Virgil E Barnes; B. A. Barnett; +210 more
    Publisher: American Physical Society
    Countries: Spain, Spain, Italy
    Project: EC | TAUKITFORNEWPHYSICS (302103), NSERC , SNSF | Measurements of Higgs bos... (153664)

    This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A. P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the Korean World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, United Kingdom; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak R&D Agency; the Academy of Finland; the Australian Research Council (ARC); and the EU community Marie Curie Fellowship Contract No. 302103. This work was also supported by the Shrum Foundation, the Weizman Institute of Science and the Israel Science Foundation. Results of a study of the substructure of the highest transverse momentum (pT) jets observed by the CDF Collaboration are presented. Events containing at least one jet with pT>400 GeV/c in a sample corresponding to an integrated luminosity of 5.95 fb−1, collected in 1.96 TeV proton-antiproton collisions at the Fermilab Tevatron collider, are selected. A study of the jet mass, angularity, and planar-flow distributions is presented, and the measurements are compared with predictions of perturbative quantum chromodynamics. A search for boosted top-quark production is also described, leading to a 95% confidence level upper limit of 38 fb on the production cross section of top quarks with pT>400 GeV/c. Peer Reviewed et al.

  • Open Access English
    Authors: 
    Claudio Maffeis; Niels H Birkebaek; Maia Konstantinova; Anke Schwandt; Andriani Vazeou; Kristina Casteels; Sujata M Jali; Catarina Limbert; Auste Pundziute-Lycka; Péter Tóth-Heyn; +13 more
    Publisher: Wiley
    Country: Portugal

    OBJECTIVE: To assess the prevalence of underweight (UW), overweight (OW), and obesity in children and adolescents with type 1 diabetes (T1D).METHODS: An international cross-sectional study including 23 026 T1D children (2-18 years, duration of diabetes ≥1 year) participating in the SWEET prospective, multicenter diabetes registry. Body mass index SD score (BMI-SDS) was calculated using the World Health Organization BMI charts. Children were categorized as UW (BMI-SDS < -2SD), OW (+1SD < BMI-SDS ≤ +2SD), and obese (OB) (BMI-SDS > +2SD). Hierarchic regression models were applied with adjustment for sex, age, and duration of diabetes.RESULTS: The prevalence of UW, OW, and obesity was: 1.4%, 22.3%, and 7.3% in males and 0.6%, 27.2%, and 6.8% in females. Adjusted BMI-SDS was significantly higher in females than in males (mean ± SEM: 0.54 ± 0.05 vs 0.40 ± 0.05, P < 0.0001). In males, BMI-SDS significantly decreased by age (P < 0.0001) in the first three age categories 0.61 ± 0.06 (2 to <10 years), 0.47 ± 0.06 (10 to <13 years), 0.34 ± 0.05 (13 to <16 years). In females, BMI-SDS showed a U-shaped distribution by age (P < 0.0001): 0.54 ± 0.04 (2 to <10 years), 0.39 ± 0.04 (10 to <13 years), 0.55 ± 0.04 (13 to <16 years). BMI-SDS increased by diabetes duration (<2 years: 0.38 ± 0.05, 2 to <5 years: 0.44 ± 0.05, and ≥5 years: 0.50 ± 0.05, P < 0.0001). Treatment modality did not affect BMI-SDS. Adjusted HbA1c was significantly higher in females than in males (8.20% ± 0.10% vs 8.06% ± 0.10%, P < 0.0001). In both genders, the association between HbA1c and BMI-SDS was U-shaped with the highest HbA1c in the UW and obesity groups.CONCLUSIONS: The high rate of OW and obesity (31.8%) emphasize the need for developing further strategies to prevent and treat excess fat accumulation in T1D.

  • Publication . Article . Preprint . Other literature type . 2013
    Open Access English
    Authors: 
    Sarah E. Medland; Jaime Derringer; Jian Yang; Tõnu Esko; Nicolas W. Martin; Konstantin Shakhbazov; Abdel Abdellaoui; Arpana Agrawal; Eva Albrecht; Behrooz Z. Alizadeh; +173 more
    Countries: Netherlands, United States, United Kingdom, Croatia, Australia
    Project: WT , NIH | FINANCIAL STATUS--RETIREM... (2P01AG005842-04), NIH | ECONOMICS OF AGING TRAINI... (5T32AG000186-10), EC | DEVHEALTH (269874), NSF | EAGER Proposal: Workshop ... (1064089), EC | GMI (230374), NIH | NBER Center for Aging and... (5P30AG012810-15)

    A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R2 ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics. Economics

  • Open Access
    Authors: 
    Jürgen Dengler; Thomas J. Matthews; Manuel J. Steinbauer; Sebastian Wolfrum; Steffen Boch; Alessandro Chiarucci; Timo Conradi; Iwona Dembicz; Corrado Marcenò; Itziar García-Mijangos; +35 more
    Publisher: Wiley
    Countries: Italy, Belgium, Italy, Portugal, Italy, Germany, Spain, Poland, Norway, Switzerland ...

    Aim Species-area relationships (SARs) are fundamental scaling laws in ecology although their shape is still disputed. At larger areas, power laws best represent SARs. Yet, it remains unclear whether SARs follow other shapes at finer spatial grains in continuous vegetation. We asked which function describes SARs best at small grains and explored how sampling methodology or the environment influence SAR shape. Location Palaearctic grasslands and other non-forested habitats. Taxa Vascular plants, bryophytes and lichens. Methods We used the GrassPlot database, containing standardized vegetation-plot data from vascular plants, bryophytes and lichens spanning a wide range of grassland types throughout the Palaearctic and including 2,057 nested-plot series with at least seven grain sizes ranging from 1 cm(2) to 1,024 m(2). Using nonlinear regression, we assessed the appropriateness of different SAR functions (power, power quadratic, power breakpoint, logarithmic, Michaelis-Menten). Based on AICc, we tested whether the ranking of functions differed among taxonomic groups, methodological settings, biomes or vegetation types. Results The power function was the most suitable function across the studied taxonomic groups. The superiority of this function increased from lichens to bryophytes to vascular plants to all three taxonomic groups together. The sampling method was highly influential as rooted presence sampling decreased the performance of the power function. By contrast, biome and vegetation type had practically no influence on the superiority of the power law. Main conclusions We conclude that SARs of sessile organisms at smaller spatial grains are best approximated by a power function. This coincides with several other comprehensive studies of SARs at different grain sizes and for different taxa, thus supporting the general appropriateness of the power function for modelling species diversity over a wide range of grain sizes. The poor performance of the Michaelis-Menten function demonstrates that richness within plant communities generally does not approach any saturation, thus calling into question the concept of minimal area. We thank all vegetation scientists who carefully collected multi‐ scale plant diversity data from Palaearctic Grasslands available in GrassPlot. The Eurasian Dry Grassland Group (EDGG) and the International Association for Vegetation Science (IAVS) sup‐ ported the EDGG Field Workshops, which generated a core part of the GrassPlot data. The Bavarian Research Alliance (grant BayIntAn_UBT_2017_58) and the Bayreuth Center of Ecology and Environmental Research (BayCEER) funded the initial GrassPlot workshop during which the database was established and the cur‐ rent paper was initiated. A.N. acknowledges support by the Center for International Scientific Studies and Collaboration (CISSC), Iran. C.M., I.B., I.G.‐M and J.A.C. were funded by the Basque Government (IT936‐16). D.V. carried out the research supported by a grant of the State Fund For Fundamental Research Ф83/53427. G.F. carried out the research in the frame of the MIUR initiative ‘Department of excellence' (Law 232/2016). I.D. was supported by the Polish National Science Centre (grant DEC‐2013/09/N/NZ8/03234). J.Do. was supported by the Czech Science Foundation (GA 17‐19376S). M.J. was supported by grant by Slovak Academy of Sciences (VEGA 02/0095/19). W.U. ac‐ knowledges support from the Polish National Science Centre (grant 2017/27/B/NZ8/00316).

  • Open Access
    Authors: 
    T. Joergensen; Thomas Graven-Nielsen; S. Rosager; L. Klokker; Karen Ellegaard; B. Danneskiold-Samsoee; Henning Bliddal; Marius Henriksen;
    Publisher: Elsevier BV
    Country: Denmark

    s / Osteoarthritis and Cartilage 21 (2013) S63–S312 S268 bunionectomy with osteotomy and fixation under regional anesthesia. Patients with a pain intensity rating of 40mm on a 100mm Visual Analog Scale (VAS) were randomized to receive indomethacin submicron particle capsules (40mg TID or BID or 20mg TID), celecoxib (400mg loading dose; 200mg BID), or placebo. The primary endpoint was the summed pain intensity difference measured by VAS over 48 hrs (VAS SPID-48). Results: Of the 462 patients enrolled, most (83.1%) were women with a mean age of 41.2 ( 12.5) years. Indomethacin submicron particle capsules 40mg TID (509.6 91.9), 40mg BID (328.0 92.9), and 20mg TID (380.5 92.9) reduced pain (VAS SPID-48; P 0.046 for all 3 groups) compared with placebo (67.8 91.4; Figure). Although there was some evidence of analgesia for celecoxib (279.4 91.9) VAS SPID-48 did not achieve statistical significance compared with placebo. Indomethacin submicron particle capsules 40mg TID (30.7; P1⁄40.013) and 40mg BID (29.8; P1⁄40.014) achieved better pain control over 4 hrs after study entry (VAS SPID-4) compared to placebo (8.9). Similarly, indomethacin submicron particle capsules 40mg TID (2.5; P1⁄40.003) and 40mg BID (2.1; P1⁄40.022) provided greater total pain relief over 4 hrs after study entry (TOTPAR-4) compared with placebo (1.2). Some evidence of pain control was observed as early as 30 min (VAS SPID) in the indomethacin submicron particle capsules 40mg TID (2.9) and 40mg BID (2.6) groups compared with placebo (0.2). AEs were generally similar across treatment groups and included nausea, localized post-procedural edema, dizziness, and headache. ĂConclusions: In this study, investigational lower-dose, indomethacin submicron particle capsules provided effective pain control compared with placebo in a post-surgical model of moderate to severe acute pain. Indomethacin submicron particle capsules are a potentially promising option for patients with acute pain. 520 ACUTE AND SHORT-TERM EFFECTS OF INTRA-ARTICULAR KNEE PAIN RELIEF ON PAIN SENSITIZATION IN KNEE OA: A COHORT STUDY T. Joergensen y, T. Graven-Nielsen z, S. Rosager y, L. Klokker y, K. Ellegaard y, B. Danneskiold-Samsoee y, H. Bliddal y, M. Henriksen y. y The Parker Inst., Dept. of Rheumatology, Copenhagen Univ.

  • Authors: 
    Ibrahim Assem; Nikolaos Marmaridis;
    Publisher: Informa UK Limited

    Let a finite dimensional algebra R be a split extension of an algebra A by a nilpotent bimodule Q. We give necessary and sufficient conditions for a (partial) tilting module TA to be such that T⊗A RR is a (partial) tilting module. If this is not the case, but QA is generated by the tilting module TA , then there exists a quotient [Rbar] of R such that T⊗A [Rbar][Rbar] is a tilting module.

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Include:
The following results are related to Canada. Are you interested to view more results? Visit OpenAIRE - Explore.
7,669 Research products, page 1 of 767
  • Closed Access
    Authors: 
    George Mylonakis; Costis Syngros; George Gazetas; Takashi Tazoh;
    Publisher: Wiley

    An investigation is presented of the collapse of a 630 m segment (Fukae section) of the elevated Hanshin Expressway during the 1995 Kobe earthquake. The earthquake has, from a geotechnical viewpoint, been associated with extensive liquefactions, lateral soil spreading, and damage to waterfront structures. Evidence is presented that soil–structure interaction (SSI) in non-liquefied ground played a detrimental role in the seismic performance of this major structure. The bridge consisted of single circular concrete piers monolithically connected to a concrete deck, founded on groups of 17 piles in layers of loose to dense sands and moderate to stiff clays. There were 18 spans in total, all of which suffered a spectacular pier failure and transverse overturning. Several factors associated with poor structural design have already been identified. The scope of this work is to extend the previous studies by investigating the role of soil in the collapse. The following issues are examined: (1) seismological and geotechnical information pertaining to the site; (2) free-field soil response; (3) response of foundation-superstructure system; (4) evaluation of results against earlier studies that did not consider SSI. Results indicate that the role of soil in the collapse was multiple: First, it modified the bedrock motion so that the frequency content of the resulting surface motion became disadvantageous for the particular structure. Second, the compliance of soil and foundation altered the vibrational characteristics of the bridge and moved it to a region of stronger response. Third, the compliance of the foundation increased the participation of the fundamental mode of the structure, inducing stronger response. It is shown that the increase in inelastic seismic demand in the piers may have exceeded 100% in comparison with piers fixed at the base. These conclusions contradict a widespread view of an always-beneficial role of seismic SSI. Copyright © 2005 John Wiley & Sons, Ltd.

  • Open Access
    Authors: 
    Morad Aaboud; Alexander Kupco; Stefan Schmitt; Ahmed Bassalat; Matej Melo; Marjorie Shapiro; Grigore Tarna; Till Eifert; Maximiliano Sioli; Nello Bruscino; +816 more
    Publisher: American Physical Society (APS)
    Project: NSERC

    A measurement of the associated production of a top-quark pair (tt) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb-1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The ttZ and ttW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σttZ=0.95±0.08stat±0.10syst pb and σttW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the ttZ cross section is used to set constraints on effective field theory operators which modify the ttZ vertex.

  • Open Access
    Authors: 
    Schellenberg, D; Armstrong Schellenberg, J R M; Mushi, A; Savigny de, D; Mgalula, L; Mbuya, C; Victoria, C.G.;
    Country: Tanzania (United Republic of)

    Objective was to document the prevalence, age-distribution, and risk factors for anaemia in Tanzanian children less than 5 years old,thereby assisting in the development of effective strategies for controlling anaemia. Cluster sampling was used to identify 2417 households at random from four contiguous districts in south-eastern United Republic of Tanzania in mid-1999. Data on various social and medical parameters were collected and analysed. Blood haemoglobin concentrations (Hb) were available for 1979 of the 2131 (93%) children identified and ranged from 1.7 to 18.6 g/dl. Overall, 87% (1722) of children had an Hb <11 g/dl, 39% (775) had an Hb <8 g/dl and 3% (65) had an Hb <5 g/dl. The highest prevalence of anaemia of all three levels was in children aged 6–11 months, of whom 10% (22/226) had an Hb <5 g/dl. However, the prevalence of anaemia was already high in children aged 1–5 months (85% had an Hb <11 g/dl, 42% had an Hb <8 g/dl, and 6% had an Hb <5 g/dl). Anaemia was usually asymptomatic and when symptoms arose they were nonspecific and rarely identified as a serious illness by the care provider. A recent history of treatment with antimalarials and iron was rare. Compliance with vaccinations delivered through the Expanded Programme of Immunization (EPI) was 82% and was notassociated with risk of anaemia. Anaemia is extremely common in south-eastern United Republic of Tanzania, even in very young infants. Further implementation of the Integrated Management of Childhood Illness algorithm should improve the case management of anaemia. However, the asymptomatic nature of most episodes of anaemia highlights the need for preventive strategies. The EPI has good coverage of the target population and it may be an appropriate channel for delivering tools for controlling anaemia and malaria.

  • Closed Access
    Authors: 
    Hongju Cheng; Naixue Xiong; Athanasios V. Vasilakos; Laurence T. Yang; Guolong Chen; Xiaofang Zhuang;
    Publisher: Elsevier BV

    The wireless mesh network is a new emerging broadband technology providing the last-mile Internet access for mobile users by exploiting the advantage of multiple radios and multiple channels. The throughput improvement of the network relies heavily on the utilizing the orthogonal channels. However, an improper channel assignment scheme may lead to network partition or links failure. In this paper we consider the assignment strategy with topology preservation by organizing the mesh nodes with available channels, and aim at minimizing the co-channel interference in the network. The channel assignment with the topology preservation is proved to be NP-hard and to find the optimized solution in polynomial time is impossible. We have formulated a channel assignment algorithm named as DPSO-CA which is based on the discrete particle swarm optimization and can be used to find the approximate optimized solution. We have shown that our algorithm can be easily extended to the case with uneven traffic load in the network. The impact of radio utilization during the channel assignment process is discussed too. Extensive simulation results have demonstrated that our algorithm has good performance in both dense and sparse networks compared with related works.

  • Open Access
    Authors: 
    T. Aaltonen; Ronen Alon; A. Anastassov; Giorgio Apollinari; Tetsuo Arisawa; A. Artikov; J. Asaadi; A. Barbaro-Galtieri; Virgil E Barnes; B. A. Barnett; +210 more
    Publisher: American Physical Society
    Countries: Spain, Spain, Italy
    Project: EC | TAUKITFORNEWPHYSICS (302103), NSERC , SNSF | Measurements of Higgs bos... (153664)

    This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A. P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the Korean World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, United Kingdom; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak R&D Agency; the Academy of Finland; the Australian Research Council (ARC); and the EU community Marie Curie Fellowship Contract No. 302103. This work was also supported by the Shrum Foundation, the Weizman Institute of Science and the Israel Science Foundation. Results of a study of the substructure of the highest transverse momentum (pT) jets observed by the CDF Collaboration are presented. Events containing at least one jet with pT>400 GeV/c in a sample corresponding to an integrated luminosity of 5.95 fb−1, collected in 1.96 TeV proton-antiproton collisions at the Fermilab Tevatron collider, are selected. A study of the jet mass, angularity, and planar-flow distributions is presented, and the measurements are compared with predictions of perturbative quantum chromodynamics. A search for boosted top-quark production is also described, leading to a 95% confidence level upper limit of 38 fb on the production cross section of top quarks with pT>400 GeV/c. Peer Reviewed et al.

  • Open Access English
    Authors: 
    Claudio Maffeis; Niels H Birkebaek; Maia Konstantinova; Anke Schwandt; Andriani Vazeou; Kristina Casteels; Sujata M Jali; Catarina Limbert; Auste Pundziute-Lycka; Péter Tóth-Heyn; +13 more
    Publisher: Wiley
    Country: Portugal

    OBJECTIVE: To assess the prevalence of underweight (UW), overweight (OW), and obesity in children and adolescents with type 1 diabetes (T1D).METHODS: An international cross-sectional study including 23 026 T1D children (2-18 years, duration of diabetes ≥1 year) participating in the SWEET prospective, multicenter diabetes registry. Body mass index SD score (BMI-SDS) was calculated using the World Health Organization BMI charts. Children were categorized as UW (BMI-SDS < -2SD), OW (+1SD < BMI-SDS ≤ +2SD), and obese (OB) (BMI-SDS > +2SD). Hierarchic regression models were applied with adjustment for sex, age, and duration of diabetes.RESULTS: The prevalence of UW, OW, and obesity was: 1.4%, 22.3%, and 7.3% in males and 0.6%, 27.2%, and 6.8% in females. Adjusted BMI-SDS was significantly higher in females than in males (mean ± SEM: 0.54 ± 0.05 vs 0.40 ± 0.05, P < 0.0001). In males, BMI-SDS significantly decreased by age (P < 0.0001) in the first three age categories 0.61 ± 0.06 (2 to <10 years), 0.47 ± 0.06 (10 to <13 years), 0.34 ± 0.05 (13 to <16 years). In females, BMI-SDS showed a U-shaped distribution by age (P < 0.0001): 0.54 ± 0.04 (2 to <10 years), 0.39 ± 0.04 (10 to <13 years), 0.55 ± 0.04 (13 to <16 years). BMI-SDS increased by diabetes duration (<2 years: 0.38 ± 0.05, 2 to <5 years: 0.44 ± 0.05, and ≥5 years: 0.50 ± 0.05, P < 0.0001). Treatment modality did not affect BMI-SDS. Adjusted HbA1c was significantly higher in females than in males (8.20% ± 0.10% vs 8.06% ± 0.10%, P < 0.0001). In both genders, the association between HbA1c and BMI-SDS was U-shaped with the highest HbA1c in the UW and obesity groups.CONCLUSIONS: The high rate of OW and obesity (31.8%) emphasize the need for developing further strategies to prevent and treat excess fat accumulation in T1D.

  • Publication . Article . Preprint . Other literature type . 2013
    Open Access English
    Authors: 
    Sarah E. Medland; Jaime Derringer; Jian Yang; Tõnu Esko; Nicolas W. Martin; Konstantin Shakhbazov; Abdel Abdellaoui; Arpana Agrawal; Eva Albrecht; Behrooz Z. Alizadeh; +173 more
    Countries: Netherlands, United States, United Kingdom, Croatia, Australia
    Project: WT , NIH | FINANCIAL STATUS--RETIREM... (2P01AG005842-04), NIH | ECONOMICS OF AGING TRAINI... (5T32AG000186-10), EC | DEVHEALTH (269874), NSF | EAGER Proposal: Workshop ... (1064089), EC | GMI (230374), NIH | NBER Center for Aging and... (5P30AG012810-15)

    A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R2 ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics. Economics

  • Open Access
    Authors: 
    Jürgen Dengler; Thomas J. Matthews; Manuel J. Steinbauer; Sebastian Wolfrum; Steffen Boch; Alessandro Chiarucci; Timo Conradi; Iwona Dembicz; Corrado Marcenò; Itziar García-Mijangos; +35 more
    Publisher: Wiley
    Countries: Italy, Belgium, Italy, Portugal, Italy, Germany, Spain, Poland, Norway, Switzerland ...

    Aim Species-area relationships (SARs) are fundamental scaling laws in ecology although their shape is still disputed. At larger areas, power laws best represent SARs. Yet, it remains unclear whether SARs follow other shapes at finer spatial grains in continuous vegetation. We asked which function describes SARs best at small grains and explored how sampling methodology or the environment influence SAR shape. Location Palaearctic grasslands and other non-forested habitats. Taxa Vascular plants, bryophytes and lichens. Methods We used the GrassPlot database, containing standardized vegetation-plot data from vascular plants, bryophytes and lichens spanning a wide range of grassland types throughout the Palaearctic and including 2,057 nested-plot series with at least seven grain sizes ranging from 1 cm(2) to 1,024 m(2). Using nonlinear regression, we assessed the appropriateness of different SAR functions (power, power quadratic, power breakpoint, logarithmic, Michaelis-Menten). Based on AICc, we tested whether the ranking of functions differed among taxonomic groups, methodological settings, biomes or vegetation types. Results The power function was the most suitable function across the studied taxonomic groups. The superiority of this function increased from lichens to bryophytes to vascular plants to all three taxonomic groups together. The sampling method was highly influential as rooted presence sampling decreased the performance of the power function. By contrast, biome and vegetation type had practically no influence on the superiority of the power law. Main conclusions We conclude that SARs of sessile organisms at smaller spatial grains are best approximated by a power function. This coincides with several other comprehensive studies of SARs at different grain sizes and for different taxa, thus supporting the general appropriateness of the power function for modelling species diversity over a wide range of grain sizes. The poor performance of the Michaelis-Menten function demonstrates that richness within plant communities generally does not approach any saturation, thus calling into question the concept of minimal area. We thank all vegetation scientists who carefully collected multi‐ scale plant diversity data from Palaearctic Grasslands available in GrassPlot. The Eurasian Dry Grassland Group (EDGG) and the International Association for Vegetation Science (IAVS) sup‐ ported the EDGG Field Workshops, which generated a core part of the GrassPlot data. The Bavarian Research Alliance (grant BayIntAn_UBT_2017_58) and the Bayreuth Center of Ecology and Environmental Research (BayCEER) funded the initial GrassPlot workshop during which the database was established and the cur‐ rent paper was initiated. A.N. acknowledges support by the Center for International Scientific Studies and Collaboration (CISSC), Iran. C.M., I.B., I.G.‐M and J.A.C. were funded by the Basque Government (IT936‐16). D.V. carried out the research supported by a grant of the State Fund For Fundamental Research Ф83/53427. G.F. carried out the research in the frame of the MIUR initiative ‘Department of excellence' (Law 232/2016). I.D. was supported by the Polish National Science Centre (grant DEC‐2013/09/N/NZ8/03234). J.Do. was supported by the Czech Science Foundation (GA 17‐19376S). M.J. was supported by grant by Slovak Academy of Sciences (VEGA 02/0095/19). W.U. ac‐ knowledges support from the Polish National Science Centre (grant 2017/27/B/NZ8/00316).

  • Open Access
    Authors: 
    T. Joergensen; Thomas Graven-Nielsen; S. Rosager; L. Klokker; Karen Ellegaard; B. Danneskiold-Samsoee; Henning Bliddal; Marius Henriksen;
    Publisher: Elsevier BV
    Country: Denmark

    s / Osteoarthritis and Cartilage 21 (2013) S63–S312 S268 bunionectomy with osteotomy and fixation under regional anesthesia. Patients with a pain intensity rating of 40mm on a 100mm Visual Analog Scale (VAS) were randomized to receive indomethacin submicron particle capsules (40mg TID or BID or 20mg TID), celecoxib (400mg loading dose; 200mg BID), or placebo. The primary endpoint was the summed pain intensity difference measured by VAS over 48 hrs (VAS SPID-48). Results: Of the 462 patients enrolled, most (83.1%) were women with a mean age of 41.2 ( 12.5) years. Indomethacin submicron particle capsules 40mg TID (509.6 91.9), 40mg BID (328.0 92.9), and 20mg TID (380.5 92.9) reduced pain (VAS SPID-48; P 0.046 for all 3 groups) compared with placebo (67.8 91.4; Figure). Although there was some evidence of analgesia for celecoxib (279.4 91.9) VAS SPID-48 did not achieve statistical significance compared with placebo. Indomethacin submicron particle capsules 40mg TID (30.7; P1⁄40.013) and 40mg BID (29.8; P1⁄40.014) achieved better pain control over 4 hrs after study entry (VAS SPID-4) compared to placebo (8.9). Similarly, indomethacin submicron particle capsules 40mg TID (2.5; P1⁄40.003) and 40mg BID (2.1; P1⁄40.022) provided greater total pain relief over 4 hrs after study entry (TOTPAR-4) compared with placebo (1.2). Some evidence of pain control was observed as early as 30 min (VAS SPID) in the indomethacin submicron particle capsules 40mg TID (2.9) and 40mg BID (2.6) groups compared with placebo (0.2). AEs were generally similar across treatment groups and included nausea, localized post-procedural edema, dizziness, and headache. ĂConclusions: In this study, investigational lower-dose, indomethacin submicron particle capsules provided effective pain control compared with placebo in a post-surgical model of moderate to severe acute pain. Indomethacin submicron particle capsules are a potentially promising option for patients with acute pain. 520 ACUTE AND SHORT-TERM EFFECTS OF INTRA-ARTICULAR KNEE PAIN RELIEF ON PAIN SENSITIZATION IN KNEE OA: A COHORT STUDY T. Joergensen y, T. Graven-Nielsen z, S. Rosager y, L. Klokker y, K. Ellegaard y, B. Danneskiold-Samsoee y, H. Bliddal y, M. Henriksen y. y The Parker Inst., Dept. of Rheumatology, Copenhagen Univ.

  • Authors: 
    Ibrahim Assem; Nikolaos Marmaridis;
    Publisher: Informa UK Limited

    Let a finite dimensional algebra R be a split extension of an algebra A by a nilpotent bimodule Q. We give necessary and sufficient conditions for a (partial) tilting module TA to be such that T⊗A RR is a (partial) tilting module. If this is not the case, but QA is generated by the tilting module TA , then there exists a quotient [Rbar] of R such that T⊗A [Rbar][Rbar] is a tilting module.