search
Include:
The following results are related to Canada. Are you interested to view more results? Visit OpenAIRE - Explore.
37,465 Research products, page 1 of 3,747

  • Canada
  • Other research products
  • 2012-2021
  • Open Access

10
arrow_drop_down
Relevance
arrow_drop_down
  • Open Access
    Authors: 
    Yap, Ellen Siew Meng;
    Country: Canada

    We, Animals is an assemblage of vignettes comprised of observations and reflections of urgent ethical issues concerning our relationship to nonhuman-animals, human-animals and more broadly to Mother Earth. Its aims are to explore and expose our paradoxical relationship with nonhuman-animals, to explore the intersections of animal ethics and veganism with other forms of oppression and exploitation such as misogyny, sexism, racism and colonialism, and to draw parallels between the oppression of nonhuman- animals and human-animals.We, Animals deviates from standard animal ethics by exposing rampant and persistent institutionalized violence in our relations with nonhuman-animals through parallel stories of Nonhuman and Human-Animal oppressions.

  • Open Access English
    Authors: 
    Low, Meaghan M.;
    Country: Canada

    In 1993, Maxine Greene issued a call to expand the standard of humanness and to look beyond normative culture in the hopes of moving toward a greater inclusivity of diversity in schools. Current Canadian curriculum theory is seeking to include more voices into a conversation that seeks to recognize unheard narratives. To contribute to this goal this study sought to speak to those who successfully navigate the normative world through their unique narratives, unswayed by the pull towards the norm. In a discussion of successful arts teachers, Smithrim and Upitis (2001) describe a person who is unswayed by normative pressures as “someone who is able to write his or her life like a poem, who marches to his or her own drum, and whose identity is strong enough to withstand the many influences of the dominant culture” (p. 21). They name these individuals strong poets. By exploring the perspectives and experiences of students who are strong poets, this research contributes to the understanding of how curriculum can encourage people to extend the standard of humanness by embracing their non-normative narratives. This study used a hermeneutic phenomenological approach. Data were collected through two phases that emphasized the interpretation of texts and the negotiation of the meaning of those texts through a community of strong poet interpreters. The data were analyzed and presented through the use of hermeneutic windows in order to develop an understanding of those who accept their own unique narratives without hesitation. The four windows described present the essence of how the strong poet participants interpreted the expansion of the standard of humanness through their awareness of self, their ability to humanize the humans around them, and the ways in which they creatively resist and negotiate norms. The strong poets who participated in this study shared their experiences of the lived curriculum and shed light on how they embraced their own non-normative narratives and how they encouraged others to embrace their own stories.

  • Open Access English
    Authors: 
    Coffey, M. P.; Løvendahl, P.; Wang, Z.; de Haas, Y.; Krattenmacher, N.; Berry, D. P.; Crowley, J. J.; Pryce, J. E.; Veerkamp, R. F.; Weigel, K.; +2 more
    Country: Canada

    Feed represents a large proportion of the variable costs in dairy production systems. The omission of feed intake measures explicitly from national dairy cow breeding objectives is predominantly due to a lack of information from which to make selection decisions. However, individual cow feed intake data are available in different countries, mostly from research or nucleus herds. None of these data sets are sufficiently large enough on their own to generate accurate genetic evaluations. In the current study, we collate data from 10 populations in 9 countries and estimate genetic parameters for dry matter intake (DMI). A total of 224,174 test-day records from 10,068 parity 1 to 5 records of 6,957 cows were available, as well as records from 1,784 growing heifers. Random regression models were fit to the lactating cow test-day records and predicted feed intake at 70 d postcalving was extracted from these fitted profiles. The random regression model included a fixed polynomial regression for each lactation separately, as well as herd-year-season of calving and experimental treatment as fixed effects; random effects fit in the model included individual animal deviation from the fixed regression for each parity as well as mean herd-specific deviations from the fixed regression. Predicted DMI at 70 d postcalving was used as the phenotype for the subsequent genetic analyses undertaken using an animal repeatability model. Heritability estimates of predicted cow feed intake 70 d postcalving was 0.34 across the entire data set and varied, within population, from 0.08 to 0.52. Repeatability of feed intake across lactations was 0.66. Heritability of feed intake in the growing heifers was 0.20 to 0.34 in the 2 populations with heifer data. The genetic correlation between feed intake in lactating cows and growing heifers was 0.67. A combined pedigree and genomic relationship matrix was used to improve linkages between populations for the estimation of genetic correlations of DMI in lactating cows; genotype information was available on 5,429 of the animals. Populations were categorized as North America, grazing, other low input, and high input European Union. Albeit associated with large standard errors, genetic correlation estimates for DMI between populations varied from 0.14 to 0.84 but were stronger (0.76 to 0.84) between the populations representative of high-input production systems. Genetic correlations with the grazing populations were weak to moderate, varying from 0.14 to 0.57. Genetic evaluations for DMI can be undertaken using data collated from international populations; however, genotype-by-environment interactions with grazing production systems need to be considered.

  • Open Access French
    Authors: 
    Paquin-Lefebvre, Frédéric;
    Publisher: Université de Montréal
    Country: Canada

    Ce mémoire concerne la modélisation mathématique de l’érythropoïèse, à savoir le processus de production des érythrocytes (ou globules rouges) et sa régulation par l’érythropoïétine, une hormone de contrôle. Nous proposons une extension d’un modèle d’érythropoïèse tenant compte du vieillissement des cellules matures. D’abord, nous considérons un modèle structuré en maturité avec condition limite mouvante, dont la dynamique est capturée par des équations d’advection. Biologiquement, la condition limite mouvante signifie que la durée de vie maximale varie afin qu’il y ait toujours un flux constant de cellules éliminées. Par la suite, des hypothèses sur la biologie sont introduites pour simplifier ce modèle et le ramener à un système de trois équations différentielles à retard pour la population totale, la concentration d’hormones ainsi que la durée de vie maximale. Un système alternatif composé de deux équations avec deux retards constants est obtenu en supposant que la durée de vie maximale soit fixe. Enfin, un nouveau modèle est introduit, lequel comporte un taux de mortalité augmentant exponentiellement en fonction du niveau de maturité des érythrocytes. Une analyse de stabilité linéaire permet de détecter des bifurcations de Hopf simple et double émergeant des variations du gain dans la boucle de feedback et de paramètres associés à la fonction de survie. Des simulations numériques suggèrent aussi une perte de stabilité causée par des interactions entre deux modes linéaires et l’existence d’un tore de dimension deux dans l’espace de phase autour de la solution stationnaire. This thesis addresses erythropoiesis mathematical modeling, which is the process of erythrocytes production and its regulation by erythropeitin. We propose an erythropoiesis model extension which includes aging of mature cells. First, we consider an age-structured model with moving boundary condition, whose dynamics are represented by advection equations. Biologically, the moving boundary condition means that the maximal lifespan varies to account for a constant degraded cells flux. Then, hypotheses are introduced to simplify and transform the model into a system of three delay differential equations for the total population, the hormone concentration and the maximal lifespan. An alternative model composed of two equations with two constant delays is obtained by supposing that the maximal lifespan is constant. Finally, a new model is introduced, which includes an exponential death rate depending on erythrocytes maturity level. A linear stability analysis allows to detect simple and double Hopf bifurcations emerging from variations of the gain in the feedback loop and from parameters associated to the survival function. Numerical simulations also suggest a loss of stability caused by interactions between two linear modes and the existence of a two dimensional torus in the phase space close to the stationary solution.

  • Open Access English
    Authors: 
    External Relations, University of Regina;
    Publisher: External Relations, University of Regina
    Country: Canada

    Thanks to everyone who has helped to make the University of Regina’s fifth annual Inspiring Leadership Forum another success. This year’s event, to be held on March 12, has once again sold out. Staff no

  • Open Access English
    Authors: 
    Hammond, Brooklyn;
    Publisher: Faculty of Arts, University of Regina
    Country: Canada

    A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Bachelor of Arts (Honours) in Psychology, University of Regina. 28 p. Chronic stress can lead to adverse physical and psychological outcomes. Empirical research demonstrates that mindfulness-interventions can serve as an effective stress-management strategy. Furthermore, individuals who are naturally more mindful (i.e., displaying higher trait mindfulness) can attenuate their psychological appraisal of stress, which may influence their physiological response (e.g., heart rate [HR]) to a stressor. The aim of the present study was to examine whether trait mindfulness predicted HR reactivity and recovery to a lab stressor. To achieve this, University of Regina students (n = 110, 78% female, 𝑀𝑀𝑀𝑀 = 21.5) were recruited via the Psychology Department’s Participant Pool. Participants partook in a modified version of the Trier Social Stress Task (TSST; Kirschbaum, Pirke, & Hellhammer, 1993). HR was measured before, during and after the laboratory stressor to assess physiological reactivity and recovery from stress. Participants subsequently completed several questionnaires examining demographic information, depression, and trait mindfulness. A paired samples t-test revealed that HR significantly increased during the TSST, implying the success of the manipulation to induce stress (p < .001). Trait mindfulness was positively correlated with HR reactivity. However, a hierarchical regression test revealed that trait mindfulness did not significantly predict HR recovery to the TSST, over and above demographic and depressive symptomatology scores (p = .135). Nonetheless, studying the moderating effects of trait mindfulness and how it influences cardiovascular functioning remains an important research endeavor. Trait mindfulness can provide insights into the efficacy of mindfulness-interventions ability to reduce stress in at-risk and general populations. Student no

  • Open Access English
    Authors: 
    Ross, M. S.; Martin, J. W.; Barker, J. F.; Sohrabi, V.;
    Country: Canada
  • Open Access
    Authors: 
    Jin, Yige (Vivian);
    Country: Canada

    It is difficult to find closed-form optimal decisions in the context of pension plans. Therefore, we often need to rely on numerical algorithms to find approximate optimal decisions. In this report, we present two numerical algorithms that can be applied to solve optimal pension funding problems: the value function approximation and the grid value approximation. The value function approximation method applies to models with infinite time horizons and approximates the parameters of the value function by minimizing the difference between the true and approximate evaluations of the Hamilton–Jacobi–Bellman (HJB) equation. The grid value approximation method is used for models with finite time horizons. It works iteratively with backward and forward stages and approximates the optimal decisions directly without using the HJB equation. Numerical results are presented to compare approximate and true solutions for optimal contributions and share in risky assets for classic problems in the pension literature.

  • Open Access
    Authors: 
    Grand Séminaire de Montréal.;
    Publisher: Montreal, La Minerve steam printing job office,
    Country: Canada
  • Open Access French
    Authors: 
    Roy, Andrée-Anne;
    Publisher: Université de Montréal
    Country: Canada

    Objectifs: Hepatocyte Growth Factor (HGF) améliore la régénération axonale et la survie des motoneurones lors du développement embryonnaire. Son rôle dans la régénération des nerfs périphériques lésés chez l’adulte n’a pas encore été étudié. Notre objectif est de déterminer l’expression de HGF dans la moelle épinière murine suite à une axotomie, avec ou sans stimulation électrique, directe ou transcutanée. Méthodes: Soixante souris C57BL/6 adultes ont été divisées en 5 groupes : Contrôle (n=12), Placebo (n=12), Axotomie (n=12, lacération et réparation immédiate du nerf sciatique), Directe (n=12, lacération, réparation immédiate et stimulation électrique directe proximale du nerf sciatique, 1h, 20 Hz) et Transcutanée (n=12, lacération, réparation immédiate et stimulation électrique transcutanée proximale du nerf sciatique, 1h, 20 Hz). Les moelles épinières ont été recueillies 1, 3, 7 et 14 jours suivant l’intervention. L’expression de HGF a été évaluée par technique d’hybridation in situ. Résultats: Nos résultats démontrent une augmentation de l’expression de HGF dans les moelles épinières murines suite à l’axotomie. Cette augmentation est plus rapide suite à la stimulation électrique, autant directe que transcutanée. L’expression de HGF devient localisée aux zones motrices de la moelle épinière murine dans les groupes Axotomie, Directe et Transcutanée. Conclusions: HGF, facteur neurotrophique impliqué de le développement et la survie des motoneurones, a une expression altérée suite à la lacération du nerf sciatique. Ceci suggère fortement qu’il participe aussi à la régénération des nerfs moteurs. De plus, l’expression plus rapide de HGF suite à la stimulation électrique suggère son implication dans l’augmentation de la régénération nerveuse. Purpose: Hepatocyte Growth Factor (HGF) plays a role in promoting axonal growth and survival of motoneurons during embryonic development. This factor might also be important in directing the regeneration of adult motoneurons following laceration. We aim to identify the expression patterns of HGF following axotomy, with or without direct or transcutaneous electrical nerve stimulation in a mouse model. Methods: Sixty adult C57BL/6 mice were divided into 5 groups: Control (n=12), Sham (n=12), Axotomy (n=12, sciatic nerve laceration and immediate repair), Direct (n=12, sciatic nerve laceration, immediate repair and application of direct electrical stimulation on the proximal nerve end, 1h, 20 Hz) and Transcutaneous (n=12, nerve laceration and immediate repair followed by proximal transcutaneous electrical stimulation, 1h, 20 Hz). Spinal cords were harvested at 1, 3, 7 and 14 days post-surgery. The expression patterns of HGF were measured using in situ hybridization. Results: Our results showed an upregulation of HGF expression in mouse spinal cords following sciatic nerve axotomy. This occurred more quickly following electrical stimulation in both Direct and Transcutaneous groups. The expression pattern of HGF became localized to the motor neuron pools in the Axotomy, Direct and Transcutaneous groups. Conclusions: HGF, a growth factor involved in directing the outgrowth of motor axons in development, has an altered expression pattern following sciatic nerve laceration, suggesting it may also play a role in directing motoneuron regeneration. Furthermore, rapid change in the expression pattern of HGF following electrical stimulation suggests it may also be involved in the upregulation of nerve regeneration following electrical stimulation.

search
Include:
The following results are related to Canada. Are you interested to view more results? Visit OpenAIRE - Explore.
37,465 Research products, page 1 of 3,747
  • Open Access
    Authors: 
    Yap, Ellen Siew Meng;
    Country: Canada

    We, Animals is an assemblage of vignettes comprised of observations and reflections of urgent ethical issues concerning our relationship to nonhuman-animals, human-animals and more broadly to Mother Earth. Its aims are to explore and expose our paradoxical relationship with nonhuman-animals, to explore the intersections of animal ethics and veganism with other forms of oppression and exploitation such as misogyny, sexism, racism and colonialism, and to draw parallels between the oppression of nonhuman- animals and human-animals.We, Animals deviates from standard animal ethics by exposing rampant and persistent institutionalized violence in our relations with nonhuman-animals through parallel stories of Nonhuman and Human-Animal oppressions.

  • Open Access English
    Authors: 
    Low, Meaghan M.;
    Country: Canada

    In 1993, Maxine Greene issued a call to expand the standard of humanness and to look beyond normative culture in the hopes of moving toward a greater inclusivity of diversity in schools. Current Canadian curriculum theory is seeking to include more voices into a conversation that seeks to recognize unheard narratives. To contribute to this goal this study sought to speak to those who successfully navigate the normative world through their unique narratives, unswayed by the pull towards the norm. In a discussion of successful arts teachers, Smithrim and Upitis (2001) describe a person who is unswayed by normative pressures as “someone who is able to write his or her life like a poem, who marches to his or her own drum, and whose identity is strong enough to withstand the many influences of the dominant culture” (p. 21). They name these individuals strong poets. By exploring the perspectives and experiences of students who are strong poets, this research contributes to the understanding of how curriculum can encourage people to extend the standard of humanness by embracing their non-normative narratives. This study used a hermeneutic phenomenological approach. Data were collected through two phases that emphasized the interpretation of texts and the negotiation of the meaning of those texts through a community of strong poet interpreters. The data were analyzed and presented through the use of hermeneutic windows in order to develop an understanding of those who accept their own unique narratives without hesitation. The four windows described present the essence of how the strong poet participants interpreted the expansion of the standard of humanness through their awareness of self, their ability to humanize the humans around them, and the ways in which they creatively resist and negotiate norms. The strong poets who participated in this study shared their experiences of the lived curriculum and shed light on how they embraced their own non-normative narratives and how they encouraged others to embrace their own stories.

  • Open Access English
    Authors: 
    Coffey, M. P.; Løvendahl, P.; Wang, Z.; de Haas, Y.; Krattenmacher, N.; Berry, D. P.; Crowley, J. J.; Pryce, J. E.; Veerkamp, R. F.; Weigel, K.; +2 more
    Country: Canada

    Feed represents a large proportion of the variable costs in dairy production systems. The omission of feed intake measures explicitly from national dairy cow breeding objectives is predominantly due to a lack of information from which to make selection decisions. However, individual cow feed intake data are available in different countries, mostly from research or nucleus herds. None of these data sets are sufficiently large enough on their own to generate accurate genetic evaluations. In the current study, we collate data from 10 populations in 9 countries and estimate genetic parameters for dry matter intake (DMI). A total of 224,174 test-day records from 10,068 parity 1 to 5 records of 6,957 cows were available, as well as records from 1,784 growing heifers. Random regression models were fit to the lactating cow test-day records and predicted feed intake at 70 d postcalving was extracted from these fitted profiles. The random regression model included a fixed polynomial regression for each lactation separately, as well as herd-year-season of calving and experimental treatment as fixed effects; random effects fit in the model included individual animal deviation from the fixed regression for each parity as well as mean herd-specific deviations from the fixed regression. Predicted DMI at 70 d postcalving was used as the phenotype for the subsequent genetic analyses undertaken using an animal repeatability model. Heritability estimates of predicted cow feed intake 70 d postcalving was 0.34 across the entire data set and varied, within population, from 0.08 to 0.52. Repeatability of feed intake across lactations was 0.66. Heritability of feed intake in the growing heifers was 0.20 to 0.34 in the 2 populations with heifer data. The genetic correlation between feed intake in lactating cows and growing heifers was 0.67. A combined pedigree and genomic relationship matrix was used to improve linkages between populations for the estimation of genetic correlations of DMI in lactating cows; genotype information was available on 5,429 of the animals. Populations were categorized as North America, grazing, other low input, and high input European Union. Albeit associated with large standard errors, genetic correlation estimates for DMI between populations varied from 0.14 to 0.84 but were stronger (0.76 to 0.84) between the populations representative of high-input production systems. Genetic correlations with the grazing populations were weak to moderate, varying from 0.14 to 0.57. Genetic evaluations for DMI can be undertaken using data collated from international populations; however, genotype-by-environment interactions with grazing production systems need to be considered.

  • Open Access French
    Authors: 
    Paquin-Lefebvre, Frédéric;
    Publisher: Université de Montréal
    Country: Canada

    Ce mémoire concerne la modélisation mathématique de l’érythropoïèse, à savoir le processus de production des érythrocytes (ou globules rouges) et sa régulation par l’érythropoïétine, une hormone de contrôle. Nous proposons une extension d’un modèle d’érythropoïèse tenant compte du vieillissement des cellules matures. D’abord, nous considérons un modèle structuré en maturité avec condition limite mouvante, dont la dynamique est capturée par des équations d’advection. Biologiquement, la condition limite mouvante signifie que la durée de vie maximale varie afin qu’il y ait toujours un flux constant de cellules éliminées. Par la suite, des hypothèses sur la biologie sont introduites pour simplifier ce modèle et le ramener à un système de trois équations différentielles à retard pour la population totale, la concentration d’hormones ainsi que la durée de vie maximale. Un système alternatif composé de deux équations avec deux retards constants est obtenu en supposant que la durée de vie maximale soit fixe. Enfin, un nouveau modèle est introduit, lequel comporte un taux de mortalité augmentant exponentiellement en fonction du niveau de maturité des érythrocytes. Une analyse de stabilité linéaire permet de détecter des bifurcations de Hopf simple et double émergeant des variations du gain dans la boucle de feedback et de paramètres associés à la fonction de survie. Des simulations numériques suggèrent aussi une perte de stabilité causée par des interactions entre deux modes linéaires et l’existence d’un tore de dimension deux dans l’espace de phase autour de la solution stationnaire. This thesis addresses erythropoiesis mathematical modeling, which is the process of erythrocytes production and its regulation by erythropeitin. We propose an erythropoiesis model extension which includes aging of mature cells. First, we consider an age-structured model with moving boundary condition, whose dynamics are represented by advection equations. Biologically, the moving boundary condition means that the maximal lifespan varies to account for a constant degraded cells flux. Then, hypotheses are introduced to simplify and transform the model into a system of three delay differential equations for the total population, the hormone concentration and the maximal lifespan. An alternative model composed of two equations with two constant delays is obtained by supposing that the maximal lifespan is constant. Finally, a new model is introduced, which includes an exponential death rate depending on erythrocytes maturity level. A linear stability analysis allows to detect simple and double Hopf bifurcations emerging from variations of the gain in the feedback loop and from parameters associated to the survival function. Numerical simulations also suggest a loss of stability caused by interactions between two linear modes and the existence of a two dimensional torus in the phase space close to the stationary solution.

  • Open Access English
    Authors: 
    External Relations, University of Regina;
    Publisher: External Relations, University of Regina
    Country: Canada

    Thanks to everyone who has helped to make the University of Regina’s fifth annual Inspiring Leadership Forum another success. This year’s event, to be held on March 12, has once again sold out. Staff no

  • Open Access English
    Authors: 
    Hammond, Brooklyn;
    Publisher: Faculty of Arts, University of Regina
    Country: Canada

    A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Bachelor of Arts (Honours) in Psychology, University of Regina. 28 p. Chronic stress can lead to adverse physical and psychological outcomes. Empirical research demonstrates that mindfulness-interventions can serve as an effective stress-management strategy. Furthermore, individuals who are naturally more mindful (i.e., displaying higher trait mindfulness) can attenuate their psychological appraisal of stress, which may influence their physiological response (e.g., heart rate [HR]) to a stressor. The aim of the present study was to examine whether trait mindfulness predicted HR reactivity and recovery to a lab stressor. To achieve this, University of Regina students (n = 110, 78% female, 𝑀𝑀𝑀𝑀 = 21.5) were recruited via the Psychology Department’s Participant Pool. Participants partook in a modified version of the Trier Social Stress Task (TSST; Kirschbaum, Pirke, & Hellhammer, 1993). HR was measured before, during and after the laboratory stressor to assess physiological reactivity and recovery from stress. Participants subsequently completed several questionnaires examining demographic information, depression, and trait mindfulness. A paired samples t-test revealed that HR significantly increased during the TSST, implying the success of the manipulation to induce stress (p < .001). Trait mindfulness was positively correlated with HR reactivity. However, a hierarchical regression test revealed that trait mindfulness did not significantly predict HR recovery to the TSST, over and above demographic and depressive symptomatology scores (p = .135). Nonetheless, studying the moderating effects of trait mindfulness and how it influences cardiovascular functioning remains an important research endeavor. Trait mindfulness can provide insights into the efficacy of mindfulness-interventions ability to reduce stress in at-risk and general populations. Student no

  • Open Access English
    Authors: 
    Ross, M. S.; Martin, J. W.; Barker, J. F.; Sohrabi, V.;
    Country: Canada
  • Open Access
    Authors: 
    Jin, Yige (Vivian);
    Country: Canada

    It is difficult to find closed-form optimal decisions in the context of pension plans. Therefore, we often need to rely on numerical algorithms to find approximate optimal decisions. In this report, we present two numerical algorithms that can be applied to solve optimal pension funding problems: the value function approximation and the grid value approximation. The value function approximation method applies to models with infinite time horizons and approximates the parameters of the value function by minimizing the difference between the true and approximate evaluations of the Hamilton–Jacobi–Bellman (HJB) equation. The grid value approximation method is used for models with finite time horizons. It works iteratively with backward and forward stages and approximates the optimal decisions directly without using the HJB equation. Numerical results are presented to compare approximate and true solutions for optimal contributions and share in risky assets for classic problems in the pension literature.

  • Open Access
    Authors: 
    Grand Séminaire de Montréal.;
    Publisher: Montreal, La Minerve steam printing job office,
    Country: Canada
  • Open Access French
    Authors: 
    Roy, Andrée-Anne;
    Publisher: Université de Montréal
    Country: Canada

    Objectifs: Hepatocyte Growth Factor (HGF) améliore la régénération axonale et la survie des motoneurones lors du développement embryonnaire. Son rôle dans la régénération des nerfs périphériques lésés chez l’adulte n’a pas encore été étudié. Notre objectif est de déterminer l’expression de HGF dans la moelle épinière murine suite à une axotomie, avec ou sans stimulation électrique, directe ou transcutanée. Méthodes: Soixante souris C57BL/6 adultes ont été divisées en 5 groupes : Contrôle (n=12), Placebo (n=12), Axotomie (n=12, lacération et réparation immédiate du nerf sciatique), Directe (n=12, lacération, réparation immédiate et stimulation électrique directe proximale du nerf sciatique, 1h, 20 Hz) et Transcutanée (n=12, lacération, réparation immédiate et stimulation électrique transcutanée proximale du nerf sciatique, 1h, 20 Hz). Les moelles épinières ont été recueillies 1, 3, 7 et 14 jours suivant l’intervention. L’expression de HGF a été évaluée par technique d’hybridation in situ. Résultats: Nos résultats démontrent une augmentation de l’expression de HGF dans les moelles épinières murines suite à l’axotomie. Cette augmentation est plus rapide suite à la stimulation électrique, autant directe que transcutanée. L’expression de HGF devient localisée aux zones motrices de la moelle épinière murine dans les groupes Axotomie, Directe et Transcutanée. Conclusions: HGF, facteur neurotrophique impliqué de le développement et la survie des motoneurones, a une expression altérée suite à la lacération du nerf sciatique. Ceci suggère fortement qu’il participe aussi à la régénération des nerfs moteurs. De plus, l’expression plus rapide de HGF suite à la stimulation électrique suggère son implication dans l’augmentation de la régénération nerveuse. Purpose: Hepatocyte Growth Factor (HGF) plays a role in promoting axonal growth and survival of motoneurons during embryonic development. This factor might also be important in directing the regeneration of adult motoneurons following laceration. We aim to identify the expression patterns of HGF following axotomy, with or without direct or transcutaneous electrical nerve stimulation in a mouse model. Methods: Sixty adult C57BL/6 mice were divided into 5 groups: Control (n=12), Sham (n=12), Axotomy (n=12, sciatic nerve laceration and immediate repair), Direct (n=12, sciatic nerve laceration, immediate repair and application of direct electrical stimulation on the proximal nerve end, 1h, 20 Hz) and Transcutaneous (n=12, nerve laceration and immediate repair followed by proximal transcutaneous electrical stimulation, 1h, 20 Hz). Spinal cords were harvested at 1, 3, 7 and 14 days post-surgery. The expression patterns of HGF were measured using in situ hybridization. Results: Our results showed an upregulation of HGF expression in mouse spinal cords following sciatic nerve axotomy. This occurred more quickly following electrical stimulation in both Direct and Transcutaneous groups. The expression pattern of HGF became localized to the motor neuron pools in the Axotomy, Direct and Transcutaneous groups. Conclusions: HGF, a growth factor involved in directing the outgrowth of motor axons in development, has an altered expression pattern following sciatic nerve laceration, suggesting it may also play a role in directing motoneuron regeneration. Furthermore, rapid change in the expression pattern of HGF following electrical stimulation suggests it may also be involved in the upregulation of nerve regeneration following electrical stimulation.