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description Publicationkeyboard_double_arrow_right Article 2021Frontiers Media SA Authors: Nikunj Sharma; Daris Pazhukkunnel Simon; Aracely Maribel Diaz-Garza; Elisa Fantino; +7 AuthorsNikunj Sharma; Daris Pazhukkunnel Simon; Aracely Maribel Diaz-Garza; Elisa Fantino; Anis Messaabi; Fatma Meddeb-Mouelhi; Fatma Meddeb-Mouelhi; Hugo Germain; Hugo Germain; Isabel Desgagné-Penix; Isabel Desgagné-Penix;The benefits of the complex microscopic and industrially important group of microalgae such as diatoms is not hidden and have lately surprised the scientific community with their industrial potential. The ability to survive in harsh conditions and the presence of different pore structures and defined cell walls have made diatoms ideal cell machinery to produce a variety of industrial products. The prospect of using a diatom cell for industrial application has increased significantly in synch with the advances in microscopy, metabarcoding, analytical and genetic tools. Furthermore, it is well noted that the approach of industry and academia to the use of genetic tools has changed significantly, resulting in a well-defined characterization of various molecular components of diatoms. It is possible to conduct the primary culturing, harvesting, and further downstream processing of diatom culture in a cost-effective manner. Diatoms hold all the qualities to become the alternative raw material for pharmaceutical, nanotechnology, and energy sources leading to a sustainable economy. In this review, an attempt has been made to gather important progress in the different industrial applications of diatoms such as biotechnology, biomedical, nanotechnology, and environmental technologies.
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For further information contact us at helpdesk@openaire.eu20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2006 CyprusIOP Publishing Authors: A.V. Georgiades; Alexander L. Kalamkarov; K.S. Challagulla;A.V. Georgiades; Alexander L. Kalamkarov; K.S. Challagulla;A general three-dimensional micromechanical model pertaining to smart composite layers with wavy boundaries is applied to the case of thin smart plates reinforced with a network of generally orthotropic bars that may also exhibit piezoelectric behavior. The method used for the development of the structural model is that of asymptotic homogenization, which reduces the original boundary value problem into a set of three decoupled problems, each problem being characterized by two differential equations. These three sets of differential equations, referred to as 'unit cell problems', deal, independently, with the elastic, piezoelectric, and thermal expansion behavior of the network-reinforced smart composite plates. The solution of the unit cell problems yields expressions for effective elastic, piezoelectric and thermal expansion coefficients which, as a consequence of their universal nature, can be used to study a wide variety of boundary value problems associated with a smart structure of a given geometry. The model can be used to customize the effective properties of a smart structure by changing some material or geometric parameters such as the size or nature of the reinforcements. The developed general methodology is applied to smart network-reinforced composite structures with generally orthotropic reinforcements and actuators. As particular examples, spatial rectangular, triangular, and rhombic smart network plates are analyzed. The general orthotropy of materials is very important from the practical viewpoint and this orthotropy makes micromechanical modeling significantly more complex. In the limiting case of isotropic reinforcements and absence of actuators, the above general orthotropic micromechanical model converges to results that are consistent with those of previous models obtained by either asymptotic homogenization, or stress-strain relationships in the isotropic reinforcements.
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For further information contact us at helpdesk@openaire.eu11 citations 11 popularity Average influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 1996Springer Berlin Heidelberg Authors: Elko J. Kleinschmidt; Horst Geschka; Robert G. Cooper;Elko J. Kleinschmidt; Horst Geschka; Robert G. Cooper;Im vorangehenden Kapitel wurden die Ergebnisse der Studie NewProd III vorgestellt. Eine wichtige Erkenntnis war, das die prozesbezogenen Erfolgsfaktoren dominieren. Die tiefergehende Analyse zeigte, das die Prozesqualitat haufig unbefriedigend war: Es wurden Aktivitaten ubersprungen oder sehr oberflachlich ausgefuhrt. Die befragten Manager sagten selbst, das viele Aktivitaten stark verbesserungsbedurftig sind.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-642-78687-7_2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FranceKorean Fluid Machinery Association Quentin Chatenet; Martin Gagnon; Emmanuel Remy; Mitra Fouladirad; Antoine Tahan;International audience
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2015 IrelandTechnological University Dublin Authors: Campbell, Brian;Campbell, Brian;There are competing forces affecting university credibility. On the one hand there is credibility in the competitive academic environment that results in the expansion of the curriculum. And on the other hand there are the increasing pressures from outside the academy for university graduates to have economically relevant workplace skills. In this paper I analyze some of the difficulties that result from these competing pressures and speculate on how they might be resolved. The example of the University of Ontario Institute of Technology is used as a new university in attempting to establish its credibility. I suggest that collegial review processes and culture will expand academic requirements to fill the available time and resources in the curriculum. I also point to a problem with innovation in curricula if the benchmark for program structures and quality assurance is a generalized university standard. If universities are to add additional components to degrees this will put pressure on the amount of time available for core academic programming as well as on the structure of that programming. Without a clear mandate and support structures to the contrary the most likely result is expanded programming for degrees.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2015 IrelandTechnological University Dublin NSERCNSERCAuthors: Reichenbacher, Helmut;Reichenbacher, Helmut;In order to provide the context for an incubator case study, this paper provides a brief overview of the support mechanisms for Canadian university-based innovation and commercialization, especially regarding government (federal, provincial, municipal). It then proceeds to describe OCAD University’s specialized commercialization and incubator unit, the Imagination Catalyst, which supports talent
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Conference object 2013 France, France, CanadaIEEE Authors: Dhaou Said; Soumaya Cherkaoui; Lyes Khoukhi;Dhaou Said; Soumaya Cherkaoui; Lyes Khoukhi;In this paper, a scheduling protocol for electric vehicle (EV) home charging with time of use pricing is introduced. This work addresses the problem of EVs charging at home by adopting an appropriate charging process protocol over Power Line Communications (PLC). The scheduling protocol is aimed at minimizing peak loads on distribution feeders due to multiple EVs charging while using a time-of-use pricing policy. Energy efficiency and performance are both taken into account. An appropriate analytical formulation of the scheduling problem is given together with the proposed scheduling protocol. Simulations demonstrate the effectiveness of the proposed approach in minimizing peak loads while satisfying the defined constraints.
PolyPublie arrow_drop_down HAL - Université de technologie de Troyes (UTT)Conference object . 2013Data sources: HAL - Université de technologie de Troyes (UTT)Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotConference object . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Average influence Average impulse Average Powered by BIP!
more_vert PolyPublie arrow_drop_down HAL - Université de technologie de Troyes (UTT)Conference object . 2013Data sources: HAL - Université de technologie de Troyes (UTT)Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotConference object . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2014 Denmark, Germany, Netherlands, United Kingdom, United Kingdom, Italy, Italy, ItalyElsevier BV Authors: Amelia Bertozzi-Villa; Megan Coggeshall; Katya Anne Shackelford; Kyle R. Heuton; +240 AuthorsAmelia Bertozzi-Villa; Megan Coggeshall; Katya Anne Shackelford; Kyle R. Heuton; Ryan M Barber; Daniel Dicker; Tara Templin; Foad Abd-Allah; Semaw Ferede Abera; Ibrahim Abubakar; Tom Achoki; Zanfina Ademi; Arsène Kouablan Adou; Jose C. Adsuar; Emilie Agardh; Deena Alasfoor; Rafael Alfonso-Cristancho; Raghib Ali; François Alla; Mohammad A. AlMazroa; Ubai Alsharif; Elena Alvarez; Nelson Alvis-Guzman; Azmeraw T. Amare; Walid Ammar; Palwasha Anwari; Johan Ärnlöv; Valentina Arsić Arsenijević; Reza Assadi; Lydia S. Atkins; Alaa Badawi; Kalpana Balakrishnan; Arindam Basu; Neeraj Bedi; Tolesa Bekele; Michelle L. Bell; Eduardo Bernabé; Zulfiqar A Bhutta; Aref A. Bin Abdulhak; Jed D. Blore; Berrak Bora Basara; Rosario Cárdenas; Carlos A Castañeda-Orjuela; Ruben Castro; Ferrán Catalá-López; Alanur Çavlin; Jung-Chen Chang; Xuan Che; Costas A. Christophi; Sumeet S. Chugh; Massimo Cirillo; Leslie T. Cooper; Iuri da Costa Leite; Rakhi Dandona; Adrian Davis; Anand Dayama; Louisa Degenhardt; Borja del Pozo-Cruz; Kebede Deribe; Muluken Dessalegn; Samath D Dharmaratne; Eric L. Ding; Rob E. Dorrington; Alireza Esteghamati; Emerito Jose A. Faraon; Farshad Farzadfar; Seyed-Mohammad Fereshtehnejad; Graça Maria Ferreira De Lima; Mohammad H. Forouzanfar; Elisabeth Barboza França; Lynne Gaffikin; Fortuné Gbètoho Gankpé; Ana C. Garcia; Johanna M. Geleijnse; Katherine B Gibney; Maurice Giroud; Elizabeth Glaser; Ketevan Goginashvili; Atsushi Goto; Hebe N. Gouda; Rajeev Gupta; Nima Hafezi-Nejad; Graeme J. Hankey; Hilda L Harb; Hans W. Hoek; Damian G Hoy; Abdullatif Husseini; Bulat Idrisov; Kaire Innos; Kathryn H. Jacobsen; Sun Ha Jee; Vivekanand Jha; Guohong Jiang; Jost B. Jonas; Knud Juel; Edmond K. Kabagambe; Nadim E. Karam; André Karch; Norito Kawakami; Konstantin Kazanjan; Andrew H. Kemp; Andre Pascal Kengne; Maia Kereselidze; Shams Eldin Ali Hassan Khalifa; Ejaz Ahmad Khan; Young-Ho Khang; Soewarta Kosen; Chanda Kulkarni; Taavi Lai; Ratilal Lalloo; Van C. Lansingh; Anders Larsson; James Leigh; Mall Leinsalu; Ricky Leung; Xiaohong Li; Yichong Li; Yongmei Li; Juan Liang; Stephen S Lim; Hsien-Ho Lin; Steven E. Lipshultz; Yang Liu; Belinda K Lloyd; Stephanie J. London; Paulo A. Lotufo; Jixiang Ma; Stefan Ma; Nana Kwaku Mainoo; Marek Majdan; Wagner Marcenes; Melvin Barrientos Marzan; Amanda J. Mason-Jones; Man Mohan Mehndiratta; Fabiola Mejía-Rodríguez; Ziad A. Memish; Walter Mendoza; Ted R. Miller; Ali H. Mokdad; Glen Mola; Lorenzo Monasta; Ami R. Moore; Maziar Moradi-Lakeh; Rintaro Mori; Mitsuru Mukaigawara; Aliya Naheed; Devina Nand; Denis Nash; Robert G. Nelson; Sudan Prasad Neupane; Charles R. Newton; Muhammad Imran Nisar; Sandra Nolte; Takayoshi Ohkubo; Bolajoko O. Olusanya; Saad B. Omer; John Nelson Opio; Orish Ebere Orisakwe; Jeyaraj D Pandian; Jae-Hyun Park; Angel J Paternina Caicedo; Scott B. Patten; Vinod K. Paul; Boris I. Pavlin; Neil Pearce; David M. Pereira; Konrad Pesudovs; Max Petzold; Guilherme V. Polanczyk; Suzanne Polinder; Daniel Pope; Farshad Pourmalek; Dima M. Qato; Kazem Rahimi; Saleem M Rana; Amany H Refaat; Luca Ronfani; Nobhojit Roy; Mohammad Ali Sahraian; Joshua A. Salomon; Uchechukwu K.A. Sampson; Itamar S. Santos; Monika Sawhney; Ione Jayce Ceola Schneider; Austin E Schumacher; David C. Schwebel; Soraya Seedat; Sadaf G. Sepanlou; Sara Sheikhbahaei; Kenji Shibuya; Hwashin Hyun Shin; Ivy Shiue; Inga Dora Sigfusdottir; Donald H. Silberberg; Andrea P. Silva; Jasvinder A. Singh; Karen Sliwa; Sergey Soshnikov; Luciano A. Sposato; Chandrashekhar T Sreeramareddy; Konstantinos Stroumpoulis; Lela Sturua; Bryan L. Sykes; Roberto Tchio Talongwa; Carolina Maria Teixeira; David L. Tirschwell; Jeffrey A. Towbin; Bach Xuan Tran; Miltiadis K. Tsilimbaris; Uche S. Uchendu; Kingsley N. Ukwaja; Eduardo A. Undurraga; Andrew Vallely; Coen H. Van Gool; Tommi Vasankari; Monica S. Vavilala; Narayanaswamy Venketasubramanian; Salvador Villalpando; Vasiliy Victorovich Vlassov; Haidong Wang; Linhong Wang; Xiao Rong Wang; Yanping Wang; Scott Weichenthal; Elisabete Weiderpass; James D. Wilkinson; Solomon Meseret Woldeyohannes; John Q. Wong; Gelin Xu; Yang Yang; Yuichiro Yano; Gokalp Kadri Yentur; Paul S. F. Yip; Naohiro Yonemoto; Seok Jun Yoon; Mustafa Z. Younis; Chuanhua Yu; Maysaa El Sayed Zaki; Yong Zhao; Maigeng Zhou; Xiao Nong Zou; Alan D. Lopez; Christopher J L Murray; Rafael Lozano;pmid: 34416194
pmc: PMC4255481
BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.METHODS: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basis of a systematic review of the relative risk of dying during pregnancy for HIV-positive women compared with HIV-negative women. We also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic review. To estimate the numbers of maternal deaths due to nine different causes, we identified 61 sources from a systematic review and 943 site-years of vital registration data. We also did a systematic review of reports about the timing of maternal death, identifying 142 sources to use in our analysis. We developed estimates for each country for 1990-2013 using Bayesian meta-regression. We estimated 95% uncertainty intervals (UIs) for all values.FINDINGS: 292,982 (95% UI 261,017-327,792) maternal deaths occurred in 2013, compared with 376,034 (343,483-407,574) in 1990. The global annual rate of change in the MMR was -0·3% (-1·1 to 0·6) from 1990 to 2003, and -2·7% (-3·9 to -1·5) from 2003 to 2013, with evidence of continued acceleration. MMRs reduced consistently in south, east, and southeast Asia between 1990 and 2013, but maternal deaths increased in much of sub-Saharan Africa during the 1990s. 2070 (1290-2866) maternal deaths were related to HIV in 2013, 0·4% (0·2-0·6) of the global total. MMR was highest in the oldest age groups in both 1990 and 2013. In 2013, most deaths occurred intrapartum or postpartum. Causes varied by region and between 1990 and 2013. We recorded substantial variation in the MMR by country in 2013, from 956·8 (685·1-1262·8) in South Sudan to 2·4 (1·6-3·6) in Iceland.INTERPRETATION: Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015. Accelerated reductions since the Millennium Declaration in 2000 coincide with increased development assistance for maternal, newborn, and child health. Setting of targets and associated interventions for after 2015 will need careful consideration of regions that are making slow progress, such as west and central Africa.FUNDING: Bill & Melinda Gates Foundation.
The Lancet arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveHelmholtz Zentrum für Infektionsforschung RepositoryArticle . 2014Data sources: Helmholtz Zentrum für Infektionsforschung RepositoryUniversity of Southern Denmark Research Output; The LancetArticle . 2014Data sources: University of Southern Denmark Research OutputNARCIS; The LancetArticle . 2014The LancetArticle . 2014Archivio della Ricerca - Università di SalernoArticle . 2014Data sources: Archivio della Ricerca - Università di Salernoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1K citations 1,127 popularity Top 0.1% influence Top 0.1% impulse Top 0.01% Powered by BIP!
visibility 1visibility views 1 download downloads 0 Powered bymore_vert The Lancet arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveHelmholtz Zentrum für Infektionsforschung RepositoryArticle . 2014Data sources: Helmholtz Zentrum für Infektionsforschung RepositoryUniversity of Southern Denmark Research Output; The LancetArticle . 2014Data sources: University of Southern Denmark Research OutputNARCIS; The LancetArticle . 2014The LancetArticle . 2014Archivio della Ricerca - Università di SalernoArticle . 2014Data sources: Archivio della Ricerca - Università di Salernoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(14)60696-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2014 PortugalOxford University Press (OUP) FCT | ANTIPEP - CONTROL OF MICR..., EC | BIOCAPSFCT| ANTIPEP - CONTROL OF MICROBIAL ADHESION AND BIOFILM FORMATION ON ABIOTIC MEDICAL SURFACES THROUGH ANTIMICROBIAL PEPTIDES-BASED PRODUCTS ,EC| BIOCAPSAnália Lourenço; Tom Coenye; Darla M. Goeres; Gianfranco Donelli; Andreia S. Azevedo; Howard Ceri; Filipa Alexandra Baltar Lobo Coelho; Hans-Curt Flemming; Talis Juhna; Susana Patrícia Lopes; Rosário Oliveira; Antonio Oliver; Mark E. Shirtliff; Ana Margarida Sousa; Paul Stoodley; Maria Olívia Pereira; Nuno F. Azevedo;The minimum information about a biofilm experiment (MIABiE) initiative has arisen from the need to find an adequate and scientifically sound way to control the quality of the documentation accompanying the public deposition of biofilm-related data, particularly those obtained using high-throughput devices and techniques. Thereby, the MIABiE consortium has initiated the identification and organization of a set of modules containing the minimum information that needs to be reported to guarantee the interpretability and independent verification of experimental results and their integration with knowledge coming from other fields. MIABiE does not intend to propose specific standards on how biofilms experiments should be performed, because it is acknowledged that specific research questions require specific conditions which may deviate from any standardization. Instead, MIABiE presents guidelines about the data to be recorded and published in order for the procedure and results to be easily and unequivocally interpreted and reproduced. Overall, MIABiE opens up the discussion about a number of particular areas of interest and attempts to achieve a broad consensus about which biofilm data and metadata should be reported in scientific journals in a systematic, rigorous and understandable manner. The authors would like to thank Thomas Bjarnsholt and Adyary Fallarero for a critical revision of the manuscript. This work was supported by IBB-CEB; Fundacao para a Ciencia e Tecnologia (FCT); the European Community fund FEDER, through Program COMPETE, in the ambit of the FCT Project PTDC/SAU-SAP/113196/2009/FCOMP-01-0124-FEDER-0 16012; the European Union Seventh Framework Programme [FP7/REGPOT-2012-2013.1] under Grant Agreement No. 316265, BIOCAPS; the Agrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa (2012/273). T. C. would like to thank FWO Vlaanderen and the Interuniversity Attraction Poles Programme initiated by the Belgian Science Policy Office for funding.
Universidade do Minh... arrow_drop_down Universidade do Minho: RepositoriUMOther literature type . 2014Data sources: Universidade do Minho: RepositoriUMRepositório Aberto da Universidade do PortoArticle . 2014Data sources: Repositório Aberto da Universidade do Portoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/2049-632x.12146&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 11visibility views 11 download downloads 4 Powered bymore_vert Universidade do Minh... arrow_drop_down Universidade do Minho: RepositoriUMOther literature type . 2014Data sources: Universidade do Minho: RepositoriUMRepositório Aberto da Universidade do PortoArticle . 2014Data sources: Repositório Aberto da Universidade do Portoadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/2049-632x.12146&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 IrelandElsevier BV Technological University DublinTechnological University DublinLaura Perdisatt; Samar Moqadasi; Luke A. J. O'Neill; Gary Hessman; Alessandra Ghion; Muhammad Qasim Mushtaq Warraich; Alan Casey; Christine O'Connor;pmid: 29452882
Regioisomers of the functional group of the main ligand (L) on a series of [Ru(phen)2L]2+and [Ru(bpy)2L]2+ complexes, where phen is 1,10 phenanthroline and bpy is 2,2′-bipyridine, were synthesised to investigate the interaction with deoxyribonucleic acid (DNA) as potential therapeutics. UV–Vis binding titrations, thermal denaturation and circular dichroism were used to evaluate their interaction with DNA. The conclusions indicated the significance of the auxiliary ligand; especially 1,10-phenanthroline has on the binding constants (Kb). The systematic variation of auxiliary ligand(phen or bpy), and polypyridyl ligand (4-(1H-Imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzonitrile (CPIP), 2-(4-formylphenyl)imidazo[4,5-f] [1,10] phenanthroline (FPIP), 2-(4-bromophenyl)imidazo[4,5-f][1,10]phenanthroline (BPIP) and 2-(4-nitrophenyl)imidazo[4,5-f] [1,10] phenanthroline (NPIP), split in terms of functional group change were investigated for DNA interaction. The CPIP analogues in particular were investigated for the regioisomerism (ortho, meta, para) effect of the nitrile group on the ligand. It was found that both the DNA interaction could be tailored through the systematic variation of the electronic nature of the individual auxiliary ligand and to a lesser extent the functional group and regioisomeric change. Preliminary cell line studies have been carried out to determine the selectivity of the complexes against cell lines such as A375 (Skin Cancer), HeLa (Cervical Cancer), A549 (Lung Cancer), Beas2B (Lung Normal Cell) and MCF-7 (Breast Cancer). Complexes which had strong DNA interactions in the binding studies have proven to be the most efficacious against certain cell lines. Establishing well-defined structure property relationships when looking at trends in spectroscopic properties and DNA binding will aid in the intelligent design of potential therapeutic complexes.
Arrow@TU Dublin arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jinorgbio.2018.01.018&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu14 citations 14 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert Arrow@TU Dublin arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jinorgbio.2018.01.018&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2021Frontiers Media SA Authors: Nikunj Sharma; Daris Pazhukkunnel Simon; Aracely Maribel Diaz-Garza; Elisa Fantino; +7 AuthorsNikunj Sharma; Daris Pazhukkunnel Simon; Aracely Maribel Diaz-Garza; Elisa Fantino; Anis Messaabi; Fatma Meddeb-Mouelhi; Fatma Meddeb-Mouelhi; Hugo Germain; Hugo Germain; Isabel Desgagné-Penix; Isabel Desgagné-Penix;The benefits of the complex microscopic and industrially important group of microalgae such as diatoms is not hidden and have lately surprised the scientific community with their industrial potential. The ability to survive in harsh conditions and the presence of different pore structures and defined cell walls have made diatoms ideal cell machinery to produce a variety of industrial products. The prospect of using a diatom cell for industrial application has increased significantly in synch with the advances in microscopy, metabarcoding, analytical and genetic tools. Furthermore, it is well noted that the approach of industry and academia to the use of genetic tools has changed significantly, resulting in a well-defined characterization of various molecular components of diatoms. It is possible to conduct the primary culturing, harvesting, and further downstream processing of diatom culture in a cost-effective manner. Diatoms hold all the qualities to become the alternative raw material for pharmaceutical, nanotechnology, and energy sources leading to a sustainable economy. In this review, an attempt has been made to gather important progress in the different industrial applications of diatoms such as biotechnology, biomedical, nanotechnology, and environmental technologies.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fmars.2021.636613&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fmars.2021.636613&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2006 CyprusIOP Publishing Authors: A.V. Georgiades; Alexander L. Kalamkarov; K.S. Challagulla;A.V. Georgiades; Alexander L. Kalamkarov; K.S. Challagulla;A general three-dimensional micromechanical model pertaining to smart composite layers with wavy boundaries is applied to the case of thin smart plates reinforced with a network of generally orthotropic bars that may also exhibit piezoelectric behavior. The method used for the development of the structural model is that of asymptotic homogenization, which reduces the original boundary value problem into a set of three decoupled problems, each problem being characterized by two differential equations. These three sets of differential equations, referred to as 'unit cell problems', deal, independently, with the elastic, piezoelectric, and thermal expansion behavior of the network-reinforced smart composite plates. The solution of the unit cell problems yields expressions for effective elastic, piezoelectric and thermal expansion coefficients which, as a consequence of their universal nature, can be used to study a wide variety of boundary value problems associated with a smart structure of a given geometry. The model can be used to customize the effective properties of a smart structure by changing some material or geometric parameters such as the size or nature of the reinforcements. The developed general methodology is applied to smart network-reinforced composite structures with generally orthotropic reinforcements and actuators. As particular examples, spatial rectangular, triangular, and rhombic smart network plates are analyzed. The general orthotropy of materials is very important from the practical viewpoint and this orthotropy makes micromechanical modeling significantly more complex. In the limiting case of isotropic reinforcements and absence of actuators, the above general orthotropic micromechanical model converges to results that are consistent with those of previous models obtained by either asymptotic homogenization, or stress-strain relationships in the isotropic reinforcements.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/0964-1726/15/5/006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu11 citations 11 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/0964-1726/15/5/006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 1996Springer Berlin Heidelberg Authors: Elko J. Kleinschmidt; Horst Geschka; Robert G. Cooper;Elko J. Kleinschmidt; Horst Geschka; Robert G. Cooper;Im vorangehenden Kapitel wurden die Ergebnisse der Studie NewProd III vorgestellt. Eine wichtige Erkenntnis war, das die prozesbezogenen Erfolgsfaktoren dominieren. Die tiefergehende Analyse zeigte, das die Prozesqualitat haufig unbefriedigend war: Es wurden Aktivitaten ubersprungen oder sehr oberflachlich ausgefuhrt. Die befragten Manager sagten selbst, das viele Aktivitaten stark verbesserungsbedurftig sind.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-642-78687-7_2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu<0 citations 0 popularity Average influence Average impulse Average Powered by BIP!