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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Bill, Kristen;

    Recent shifts in wildfire activity in regions of boreal North America indicate decreased resiliency of carbon pools and forest state. Here, I quantify the initial response and long-term recovery of belowground carbon pools to wildfire across various vegetation trajectories in ~140,000km2 area of the Northwest Territories, Canada, across 502 stands ranging from 1-100 years post-fire. Recovery of soil organic carbon depth and stocks post-fire are regulated primarily by time, moisture level, and their interaction. Hydric sites store more carbon than mesic and dry sites, and rates of post-fire soil carbon accumulation are slower in wetter stands than in mesic or dry stands. My results also suggest that shifts in vegetation state are likely to reduce soil organic carbon depth and stocks during the fire-free period. By modelling across gradients of fire history, hydrology, and vegetation dominance, we can predict the short- and long-term consequences of wildfire for ecosystem carbon behaviour. This research was funded by Northern Science Training Program (NSTP), Northern Water Futures, NASA, and was in kind partnership with the Government of the Northwest Territories.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ DSpace at the Univer...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kaller, Damon M;
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Simon Fraser Univers...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Simon Fraser Univers...arrow_drop_down
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    Authors: Wally, Owen Stephen Donald;

    Genetic engineering is a promising strategy for creating agriculturally significant resistance in carrot. Several different transgenic strategies, in addition to conducting a detailed quantification of commonly used promoters to achieve disease resistance were investigated. Tissue-specific patterns and levels of protein expression were characterized in transgenic carrot plants transformed with the ?-glucuronidase gene driven by five promoters: Cauliflower moasaic virus 35S, double 35S (D35S), Arabidopsis ubiquitin (UBQ3), mannopine synthase (mas2) or rooting loci promoter (rolD). UBQ3 promoter provided the highest levels of expression in roots, while D35S and 35S promoters had high expression in leaves. rolD and Mas2 promoters had enhanced root expression; however levels were much lower compared to the constitutive promoters, which were subsequently used in this research. Genes encoding a rice peroxidase (POC1), wheat chitinase (383) and ?1,3- glucanase (638) were introduced into carrot. Lines expressing 638 alone had no enhanced resistance to B. cinerea or S. scleorotiorum, while 383 lines reduced disease symptoms by up to 40%. When 638 and 383 were co-expressed resistance levels were similar to 383 alone. High levels of disease resistance were seen in lines expressing POC1 with 70-90% reduction in symptoms to B. cinerea and S. sclerotiorum. POC1 lines had 20-30% increases in lignin levels in petioles and roots, which was enhanced with pathogen challenge. Several defence genes exhibited strong induction in POC1 expressing plants when induced with fungal cell wall elicitor. Additionally, POC1 lines had reduced H2O2 accumulation during oxidative burst response. POC1 derived resistance was effective towards necrotrophic pathogens. Over-expression of Arabidopsis Nonexpressor of Pathogenesis Related protein 1 was studied in carrot, with two independent lines successfully generated and analyzed. There was no detectable activation of the systemic acquire resistance (SAR) pathways in the absence of pathogens, however, the lines exhibited more intense and longer lasting activation of SAR when elicited with fungal cell walls or Salicylic acid. Both lines were highly resistant against biotrophic and necrotrophic foliar pathogens and the roots were resistant towards A. radicina, indicating broad-spectrum disease resistance. The results from this study demonstrate the feasibility of engineering disease resistance in carrot using several different approaches.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Simon Fraser Univers...arrow_drop_down
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    Authors: Sailaja, Dronamraju Rani;

    This is an ethnographic study of SOSAD (Save Our Sons And Daughters), which is a Detroit-based, self-help organization of parents and relatives whose children have been killed by other children. This organization formed through the collective effort of a group of parents led by Ms. Clementine Barfield whose son was killed in Detroit. The organization has the following objectives: a) Providing a support group for the parents whose children are killed. b) Actions to increase awareness of the problem and to create programmes aimed toward prevention of crime and the protection of the community. c) Lobbying for legislation to prevent the sale and use of guns, particularly handguns. This research describes the history and formation of SOSAD and attempts to assess the ways in which SOSAD members construct their definitions of the problem of "kids killing kids", as well as their perspectives on the causes and solutions. It includes an assessment of the organization's potential and it's dual role as a self-help group and national grass-roots movement. This research includes a profile of the child and youth killings and patterns of killing for the years 1984-'88. A comparision of SOSAD with similar organizations in the war zones" in Los Angeles, Washington and Chicago is included along with a review of children in war in different parts of the world. This research mainly focusses on SOSAD and it's formation and on the processes and activities, which help it achieve the goal of curbing the problem of children killing children. A Symbolic Interaction perspective is adopted by this research. A qualitative methodology of participant observation and interactive interviews is utilised to obtain data about the organization. The conclusions drawn from the research are the following: a) SOSAD has an impact on the community. The organization has effectively raised the consciousness of the community regarding the problem. b) It's role as a counsellor and a support group helps the parents alleviate their grief. c) It voices the community's anguish against the increasing availability of drugs and guns. d) There are similar organizations which, like SOSAD, fight the problem of children killing children in some of the major cities of United States. SOSAD has acquired a position of organizations. leadership and the respect of the other This research involved the study of the organization, SOSAD, which began as self-help group and is now a nationally recognised national movement.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Dong, Weihang (Norman);

    Design of earthquake-resistant structures has been an important area in both research and engineering practice for decades. Realistic determination of seismic loading on structures is one of the governing design criteria for design of new buildings or evaluation of existing structures. For the nuclear industry, the performance of structures is extremely important owing to public safety concerns. This report explores the methodologies used to calculate seismic-induced soil pressure applied onto partially embedded structures. A critical review was performed on different methods developed in the past, which includes simplified analytical approaches based on either yielding wall theory or rigid wall theory and detailed dynamic analysis with the consideration of soil-structure interaction effects. Assumptions, range for appropriate application, and corresponding shortcomings of these methods are identified. Several critical issues that have significant impact on the soil-structural response but are not sufficiently taken into account in most existing models, are identified. These include embedment effects, interface boundary conditions and material nonlinearity. Following the review, a detailed seismic analysis using the finite element method is carried out to explore the effects of embedment effects, interface boundary conditions and material nonlinearity on seismic earth pressure. A simplified CANDU 6 reactor building excited by an artificial strong ground motion is used in this analysis. The seismic earth pressures obtained from this detailed seismic analyses under various conditions are then compared with the simplified approaches to evaluate their accuracy. Master of Engineering (ME)

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    Thesis . 2011
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      Thesis . 2011
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    Authors: Pettitt-Wade, Harri;

    A developing concept in ecology is that broad niches predict geographical range size. Plasticity in resource use is often considered to be important for responding to novel environments, and study of species that are established across different ranges provides a model for determining the drivers of species spread and distribution. Contrasting distributions of invasive species are often associated with species-specific feeding ecology, but comparisons are rarely made for multiple taxa, spatial scales or between native and invaded ranges.

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    Scholarship at UWindsor
    Doctoral thesis . 2016
    License: CC BY NC ND
    ResearchGate Data
    Thesis . 2016
    Data sources: Datacite
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      Scholarship at UWindsor
      Doctoral thesis . 2016
      License: CC BY NC ND
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      Thesis . 2016
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    Authors: Liang, Chen Ting;

    Cancer is the leading cause of death worldwide, with breast cancer being one of the most common types. To date, more than 1700 distinct mutations have been identified in the Breast Cancer type-1 susceptibility (BRCA1) gene. One of the protein partners of BRCA1 is the BRCA1-Associated RING Domain protein 1 (BARD1). The association between these two proteins form the BRCA1-BARD1 heterodimer, which is essential for the complex’s stability and E3 ubiquitin ligase activity. The BRCA1-BARD1 heterodimer has been shown to promote double stranded break (DSB) repair in the DNA damage response (DDR) signaling pathway. Although its E3 ligase function has been confirmed, the significance with respect to DSB repair remains unclear and highly debated. To better clarify its involvement in DDR, I have utilized the ubiquitin variant (UbV) technology to develop modulators targeting the BRCA1-BARD1 heterodimer. Here, 22 UbVs were identified in phage display sections using different versions of the BRCA1-BARD1 complex, 21/22 were protein purified, 17/21 biochemically characterized in substrate ubiquitination assays and 4/17 assessed in cellular assays. One of the UbV binders was shown to affect the DSB repair pathway by modulating BRCA1-BARD1 activity. In the future, more work is needed to fully characterize this UbV and its cellular effects. I conclude that this UbV provides a foundation that will allow us to further explore BRCA1-BARD’s involvement in DDR.

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    Authors: Fredette, Conrad Maurice;

    The reaction between chloropentacarbonyl rhenium(I) and β-diketones is shown to give two types of poducts, Re₂(CO)₆(dik)₂. A unique structure could not be established for either type using infra-red, nmr, mass spectrometry and magnetic measurements. Thus, a crystal structure of one member from each series was undertaken to solve the problem. Re₂(CO)₆Cℓ₂(bamH)₂: the two halves of the molecule are related by a two fold axis and are held together by chlorine bridges. The neutral β-ketoenol groups are cis to-the chlorine bridges, are both on the same side of the molecule, and are each bonded to the rhenium atom via only one oxygen. Re₂(CO)₆(dbm)₂: the two halves of the molecule are related by an inversion centre and are held together by one bridging oxygen from each β-diketone group. The angle between the O-Re-O plane and the OCCCO S-diketone plane is 37°, the largest ever observed for a metal β-diketonate. The Re2(CO)6(dik)2 series was shown to undergo bridge breaking and further substitution to give products of the type Re(CO)₃dik)L and Re(CO)₂(dik)L₂ where L = Co, py, Ph₃P. Finally, the crystal structure of an impurity, Re₂Cℓ₄(CO)ᵪ, was partially solved. Doctor of Philosophy (PhD)

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    MacSphere
    Thesis . 1973
    Data sources: MacSphere
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      Thesis . 1973
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    Authors: Burton, Alexander J;
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    Authors: Chan, Jessica Gin-Jade;

    This report is a case study that explores Ricepapr magazine's efforts to develop a content management system (CMS) at a time when the small non-profit publication was reorganising its internal administration and publishing process. Magazines traditionally facilitate the fluid relationship between community and content. This report is a case study that examines how RicepaperMagazine ("Ricepaper")-a small non-profit publication-used technology and software to streamline its work cycle and build intracommunity networks. It documents and explores the magazine's attempts to develop Ricecooker, a software system that was conceptualised to improve communications and unify all department processes with a centralised content management system (CMS). By detailing an in-depth look at Ricepapeer's development experience, this report undertakes an examination of all the attendant issues that accompany such a projectorganisational evolution, decision-making, system limitations, unforeseen problems, and unexpected solutions. It will also look at how Ricepaperhas utilised alternative communication technologies to semi-automate their workflows, promote cross-unit interaction, and deepen the magazine's relationship with readers and staff communities. Overall, this report offers insight to: the production workflow at a volunteer-based publication, and the management of an evolving magazine. Finally, some reflections are offered with regard to planning for change, and how process management can inform software development.

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48,049 Research products
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    Authors: Bill, Kristen;

    Recent shifts in wildfire activity in regions of boreal North America indicate decreased resiliency of carbon pools and forest state. Here, I quantify the initial response and long-term recovery of belowground carbon pools to wildfire across various vegetation trajectories in ~140,000km2 area of the Northwest Territories, Canada, across 502 stands ranging from 1-100 years post-fire. Recovery of soil organic carbon depth and stocks post-fire are regulated primarily by time, moisture level, and their interaction. Hydric sites store more carbon than mesic and dry sites, and rates of post-fire soil carbon accumulation are slower in wetter stands than in mesic or dry stands. My results also suggest that shifts in vegetation state are likely to reduce soil organic carbon depth and stocks during the fire-free period. By modelling across gradients of fire history, hydrology, and vegetation dominance, we can predict the short- and long-term consequences of wildfire for ecosystem carbon behaviour. This research was funded by Northern Science Training Program (NSTP), Northern Water Futures, NASA, and was in kind partnership with the Government of the Northwest Territories.

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    Authors: Kaller, Damon M;
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    Authors: Wally, Owen Stephen Donald;

    Genetic engineering is a promising strategy for creating agriculturally significant resistance in carrot. Several different transgenic strategies, in addition to conducting a detailed quantification of commonly used promoters to achieve disease resistance were investigated. Tissue-specific patterns and levels of protein expression were characterized in transgenic carrot plants transformed with the ?-glucuronidase gene driven by five promoters: Cauliflower moasaic virus 35S, double 35S (D35S), Arabidopsis ubiquitin (UBQ3), mannopine synthase (mas2) or rooting loci promoter (rolD). UBQ3 promoter provided the highest levels of expression in roots, while D35S and 35S promoters had high expression in leaves. rolD and Mas2 promoters had enhanced root expression; however levels were much lower compared to the constitutive promoters, which were subsequently used in this research. Genes encoding a rice peroxidase (POC1), wheat chitinase (383) and ?1,3- glucanase (638) were introduced into carrot. Lines expressing 638 alone had no enhanced resistance to B. cinerea or S. scleorotiorum, while 383 lines reduced disease symptoms by up to 40%. When 638 and 383 were co-expressed resistance levels were similar to 383 alone. High levels of disease resistance were seen in lines expressing POC1 with 70-90% reduction in symptoms to B. cinerea and S. sclerotiorum. POC1 lines had 20-30% increases in lignin levels in petioles and roots, which was enhanced with pathogen challenge. Several defence genes exhibited strong induction in POC1 expressing plants when induced with fungal cell wall elicitor. Additionally, POC1 lines had reduced H2O2 accumulation during oxidative burst response. POC1 derived resistance was effective towards necrotrophic pathogens. Over-expression of Arabidopsis Nonexpressor of Pathogenesis Related protein 1 was studied in carrot, with two independent lines successfully generated and analyzed. There was no detectable activation of the systemic acquire resistance (SAR) pathways in the absence of pathogens, however, the lines exhibited more intense and longer lasting activation of SAR when elicited with fungal cell walls or Salicylic acid. Both lines were highly resistant against biotrophic and necrotrophic foliar pathogens and the roots were resistant towards A. radicina, indicating broad-spectrum disease resistance. The results from this study demonstrate the feasibility of engineering disease resistance in carrot using several different approaches.

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    Authors: Sailaja, Dronamraju Rani;

    This is an ethnographic study of SOSAD (Save Our Sons And Daughters), which is a Detroit-based, self-help organization of parents and relatives whose children have been killed by other children. This organization formed through the collective effort of a group of parents led by Ms. Clementine Barfield whose son was killed in Detroit. The organization has the following objectives: a) Providing a support group for the parents whose children are killed. b) Actions to increase awareness of the problem and to create programmes aimed toward prevention of crime and the protection of the community. c) Lobbying for legislation to prevent the sale and use of guns, particularly handguns. This research describes the history and formation of SOSAD and attempts to assess the ways in which SOSAD members construct their definitions of the problem of "kids killing kids", as well as their perspectives on the causes and solutions. It includes an assessment of the organization's potential and it's dual role as a self-help group and national grass-roots movement. This research includes a profile of the child and youth killings and patterns of killing for the years 1984-'88. A comparision of SOSAD with similar organizations in the war zones" in Los Angeles, Washington and Chicago is included along with a review of children in war in different parts of the world. This research mainly focusses on SOSAD and it's formation and on the processes and activities, which help it achieve the goal of curbing the problem of children killing children. A Symbolic Interaction perspective is adopted by this research. A qualitative methodology of participant observation and interactive interviews is utilised to obtain data about the organization. The conclusions drawn from the research are the following: a) SOSAD has an impact on the community. The organization has effectively raised the consciousness of the community regarding the problem. b) It's role as a counsellor and a support group helps the parents alleviate their grief. c) It voices the community's anguish against the increasing availability of drugs and guns. d) There are similar organizations which, like SOSAD, fight the problem of children killing children in some of the major cities of United States. SOSAD has acquired a position of organizations. leadership and the respect of the other This research involved the study of the organization, SOSAD, which began as self-help group and is now a nationally recognised national movement.

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    Authors: Dong, Weihang (Norman);

    Design of earthquake-resistant structures has been an important area in both research and engineering practice for decades. Realistic determination of seismic loading on structures is one of the governing design criteria for design of new buildings or evaluation of existing structures. For the nuclear industry, the performance of structures is extremely important owing to public safety concerns. This report explores the methodologies used to calculate seismic-induced soil pressure applied onto partially embedded structures. A critical review was performed on different methods developed in the past, which includes simplified analytical approaches based on either yielding wall theory or rigid wall theory and detailed dynamic analysis with the consideration of soil-structure interaction effects. Assumptions, range for appropriate application, and corresponding shortcomings of these methods are identified. Several critical issues that have significant impact on the soil-structural response but are not sufficiently taken into account in most existing models, are identified. These include embedment effects, interface boundary conditions and material nonlinearity. Following the review, a detailed seismic analysis using the finite element method is carried out to explore the effects of embedment effects, interface boundary conditions and material nonlinearity on seismic earth pressure. A simplified CANDU 6 reactor building excited by an artificial strong ground motion is used in this analysis. The seismic earth pressures obtained from this detailed seismic analyses under various conditions are then compared with the simplified approaches to evaluate their accuracy. Master of Engineering (ME)

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    MacSphere
    Thesis . 2011
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      Thesis . 2011
      Data sources: MacSphere
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    Authors: Pettitt-Wade, Harri;

    A developing concept in ecology is that broad niches predict geographical range size. Plasticity in resource use is often considered to be important for responding to novel environments, and study of species that are established across different ranges provides a model for determining the drivers of species spread and distribution. Contrasting distributions of invasive species are often associated with species-specific feeding ecology, but comparisons are rarely made for multiple taxa, spatial scales or between native and invaded ranges.

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    Scholarship at UWindsor
    Doctoral thesis . 2016
    License: CC BY NC ND
    ResearchGate Data
    Thesis . 2016
    Data sources: Datacite
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      Scholarship at UWindsor
      Doctoral thesis . 2016
      License: CC BY NC ND
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      Thesis . 2016
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    Authors: Liang, Chen Ting;

    Cancer is the leading cause of death worldwide, with breast cancer being one of the most common types. To date, more than 1700 distinct mutations have been identified in the Breast Cancer type-1 susceptibility (BRCA1) gene. One of the protein partners of BRCA1 is the BRCA1-Associated RING Domain protein 1 (BARD1). The association between these two proteins form the BRCA1-BARD1 heterodimer, which is essential for the complex’s stability and E3 ubiquitin ligase activity. The BRCA1-BARD1 heterodimer has been shown to promote double stranded break (DSB) repair in the DNA damage response (DDR) signaling pathway. Although its E3 ligase function has been confirmed, the significance with respect to DSB repair remains unclear and highly debated. To better clarify its involvement in DDR, I have utilized the ubiquitin variant (UbV) technology to develop modulators targeting the BRCA1-BARD1 heterodimer. Here, 22 UbVs were identified in phage display sections using different versions of the BRCA1-BARD1 complex, 21/22 were protein purified, 17/21 biochemically characterized in substrate ubiquitination assays and 4/17 assessed in cellular assays. One of the UbV binders was shown to affect the DSB repair pathway by modulating BRCA1-BARD1 activity. In the future, more work is needed to fully characterize this UbV and its cellular effects. I conclude that this UbV provides a foundation that will allow us to further explore BRCA1-BARD’s involvement in DDR.

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    Authors: Fredette, Conrad Maurice;

    The reaction between chloropentacarbonyl rhenium(I) and β-diketones is shown to give two types of poducts, Re₂(CO)₆(dik)₂. A unique structure could not be established for either type using infra-red, nmr, mass spectrometry and magnetic measurements. Thus, a crystal structure of one member from each series was undertaken to solve the problem. Re₂(CO)₆Cℓ₂(bamH)₂: the two halves of the molecule are related by a two fold axis and are held together by chlorine bridges. The neutral β-ketoenol groups are cis to-the chlorine bridges, are both on the same side of the molecule, and are each bonded to the rhenium atom via only one oxygen. Re₂(CO)₆(dbm)₂: the two halves of the molecule are related by an inversion centre and are held together by one bridging oxygen from each β-diketone group. The angle between the O-Re-O plane and the OCCCO S-diketone plane is 37°, the largest ever observed for a metal β-diketonate. The Re2(CO)6(dik)2 series was shown to undergo bridge breaking and further substitution to give products of the type Re(CO)₃dik)L and Re(CO)₂(dik)L₂ where L = Co, py, Ph₃P. Finally, the crystal structure of an impurity, Re₂Cℓ₄(CO)ᵪ, was partially solved. Doctor of Philosophy (PhD)

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    Thesis . 1973
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      Thesis . 1973
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    Authors: Burton, Alexander J;
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