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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Administrator, UWindsor;
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Scholarship at UWind...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Scholarship at UWindsor
    Other literature type . 2016
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Scholarship at UWind...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Scholarship at UWindsor
      Other literature type . 2016
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Tran, Hong Hanh;

    Virus-based expression systems have been widely exploited for the production of recombinant proteins in plants during the last three decades. Advances in technology have boosted scale-up manufacturing of plant-made pharmaceuticals to high levels, via the complementation of transient expression and viral vectors. This combination allows proteins of interest to be produced in plants within a matter of days and thus, is well suited for the development of plant-made vaccines or therapeutics against emerging infectious diseases and potential bioterrorism agents. Several plant-based products are currently in varying stages of clinical development. To investigate the viability of virus-based expression systems for plant-made subunit vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV), I have developed several viral vectors which express partial PRRSV glycoprotein 5 (GP5). In this thesis, I demonstrated that viral vectors can increase the expression of proteins for vaccine development in a variety of host plants. Green fluorescent protein (GFP) and the C-terminus of GP5 fused with GFP (GP5C-GFP) were expressed at up to 37.29 mg/kg and 4.36 mg/kg fresh weight of leaf tissue, respectively, in soybean plants via biolistic bombardment, using viral vectors derived from Bean pod mottle virus (BPMV). A Cucumber green mottle mosaic virus (CGMMV)-based vector was employed to display chimeric virus particles, presenting the neutralizing epitope (NE) of GP5, at levels as high as 35.84 mg/kg of cucumber leaf fresh weight, via agroinfiltration. In addition, GFP and the ectodomain of GP5 fused with GFP (GP5e-GFP) were successfully produced at up to 2.03 g/kg and 36.53 mg/kg fresh weight of leaf tissue, respectively, in Nicotiana benthamiana using transient expression of Pepino mosaic virus (PepMV)-based vectors. Co-infiltration of viral vectors with p19, a silencing suppressor, can help to mitigate the toxicity of GP5e to plant tissue and enhance the accumulation of this protein. These plant-made products may be tested as oral subunit vaccines against PRRSV in pigs during future experimental trials. Overall, the results demonstrate that viral systems can produce low-cost, versatile and robust vaccines that have a great impact in the fight against viral diseases, especially in developing countries.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Scholarship@Westernarrow_drop_down
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    Scholarship@Western
    Other literature type . 2017
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Scholarship@Western
      Other literature type . 2017
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: J Johnson; David A. Case; T Yamazaki; Sergey Gusarov; +2 Authors

    Implicit solvent models offer an attractive way to estimate the effects of a solvent environment on the properties of small or large solutes without the complications of explicit simulations. One common test of accuracy is to compute the free energy of transfer from gas to liquid for a variety of small molecules, since many of these values have been measured. Studies of the temperature dependence of these values (i.e. solvation enthalpies and entropies) can provide additional insights into the performance of implicit solvent models. Here, we show how to compute temperature derivatives of hydration free energies for the 3D-RISM integral equation approach. We have computed hydration free energies of 1123 small drug-like molecules (both neutral and charged). Temperature derivatives were also used to calculate hydration energies and entropies of 74 of these molecules (both neutral and charged) for which experimental data is available. While direct results have rather poor agreement with experiment, we have found that several previously proposed linear hydration free energy correction schemes give good agreement with experiment. These corrections also provide good agreement for hydration energies and entropies though simple extensions are required in some cases.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Journal of Physics C...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Europe PubMed Central
    Other literature type . 2016
    Data sources: PubMed Central
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Journal of Physics Condensed Matter
    Article . 2016
    License: IOP Copyright Policies
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Journal of Physics C...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Europe PubMed Central
      Other literature type . 2016
      Data sources: PubMed Central
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of Physics Condensed Matter
      Article . 2016
      License: IOP Copyright Policies
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Limic, Vlada; Sturm, Anja;

    This paper extends the notion of the $\la$-coalescent of Pitman (1999) to the spatial setting. The partition elements of the spatial $\Lambda$-coalescent migrate in a (finite) geographical space and may only coalesce if located at the same site of the space. We characterize the $\Lambda$-coalescents that come down from infinity, in an analogous way to Schweinsberg (2000). Surprisingly, all spatial coalescents that come down from infinity, also come down from infinity in a uniform way. This enables us to study space-time asymptotics of spatial $\Lambda$-coalescents on large tori in $d\ge 3$ dimensions. Our results generalize and strengthen those of Greven et al. (2005), who studied the spatial Kingman coalescent in this context. Comment: 29 pages

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Electronic Journal o...arrow_drop_down
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    Electronic Journal of Probability
    Other literature type . 2006
    Data sources: Project Euclid
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Electronic Journal o...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Electronic Journal of Probability
      Other literature type . 2006
      Data sources: Project Euclid
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Igue, Charlemagne Babatoundé;

    Cet article étudie le lien entre l’efficacité de l’intermédiation financière et la croissance économique sur un panel de sept pays de l’UEMOA** sur la période 1990-2008. Tout d’abord, un modèle théorique est présenté dans lequel l’efficacité de l’intermédiation bancaire renforce la croissance économique par le biais de l’amélioration de la productivité marginale du capital. Ensuite, l’efficacité du secteur bancaire est étudiée par le concept d’efficacité-X de Leibenstein (1966). Les scores d’efficacité bancaire sont estimés par la méthode DEA (Data Envelopment Analysis), appliquée à un modèle de production bancaire sur un échantillon de banques de l’UEMOA. Finalement, les scores moyens d’efficacité bancaire par pays sont calculés et utilisés comme indicateur de l’efficacité de l’intermédiation financière dans un modèle de croissance sur données de panel. Les résultats suggèrent l’existence d’une influence positive et significative de l’efficacité du secteur bancaire sur la croissance économique. This paper explores the connection between financial intermediation efficiency and economic growth on a panel of seven countries of WAEMU from 1990 to 2008. First, a theoretical model is presented in which financial efficiency enhances economic growth by means of increasing the marginal productivity of capital. Next, the banking sector efficiency is apprehended by the X-efficiency concept of Leibenstein (1966). Banking efficiency scores are estimated with Data Envelopment Analysis method, applied to banking production model on a sample of banks of the WAEMU. Finally, average scores of banking efficiency by country are calculated and used as indicator of financial intermediation efficiency in a growth model on panel data. Results suggest the existence of a positive impact of the banking sector efficiency on the economic growth.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ L Actualité économiq...arrow_drop_down
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    L Actualité économique; Érudit
    Other literature type . Article . 2014
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ L Actualité économiq...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      L Actualité économique; Érudit
      Other literature type . Article . 2014
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Guéroult, Martial;

    L'auteur expose les principes de la méthode qu'il applique dans ses études d'histoire de la philosophie. Il distingue entre l'histoire horizontale de la philosophie qui s'intéresse surtout aux aspects historiques des systèmes philosophiques et l'histoire verticale de la philosophie qui s'intéresse d'abord aux doctrines proprement philosophiques. L'histoire verticale de la philosophie peut se faire selon deux méthodes différentes : la méthode des sources et la méthode des structures. L'auteur montre la supériorité de la méthode des structures pour dégager l'intelligibilité interne de l'oeuvre, méthode qu'il présente comme une méthode des raisons. La méthode des structures correspond à la nature de l'oeuvre philosophique, d'une part, en tant qu'oeuvre, d'autre part, en tant que philosophique. The author shows the principles of the method that he applies in his studies on the history of philosophy. He distinguishes between the horizontal history of philosophy that interests primarily on the historical aspects of the philosophical systems and the vertical history of philosophy that interests at first to the philosophical doctrines. The vertical history of philosophy can be made according to two different methods : the method of source and the method of structures. The author shows the superiority of the method of structures to grasp the internal intelligibility of the philosophical work, method presented as a methodof reasons. The method of structures is adequate to the nature of the philosophical work, as work and as philosophical.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Philosophiquesarrow_drop_down
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    Philosophiques
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    Philosophiques; Érudit
    Other literature type . Article . 2006
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      Philosophiques
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      Philosophiques; Érudit
      Other literature type . Article . 2006
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    Authors: Michael, Gaies; Sarah, Tabbutt; Steven M, Schwartz; Geoffrey L, Bird; +11 Authors

    OBJECTIVE To describe the clinical epidemiology of extubation failure in a multicenter cohort of patients treated in pediatric cardiac ICUs. DESIGN Retrospective cohort study using prospectively collected clinical registry data. SETTING Pediatric Cardiac Critical Care Consortium registry. PATIENTS All patients admitted to the CICU at Pediatric Cardiac Critical Care Consortium hospitals. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Analysis of all mechanical ventilation episodes in the registry from October 1, 2013, to July 31, 2014. The primary outcome of extubation failure was reintubation less than 48 hours after planned extubation. Repeated-measures analysis using generalized estimating equations to account for within patient and center correlation was performed to identify risk factors for extubation failure. Adjusted extubation failure rates for each hospital were calculated using logistic regression controlling for patient factors. Of 1,734 mechanical ventilation episodes (1,478 patients at eight hospitals) ending in a planned extubation, there were 100 extubation failures (5.8%). In multivariable analysis, only longer duration of mechanical ventilation was significantly associated with extubation failure (p = 0.01); the failure rate was 4% when ventilated less than 24 hours, 9% after 24 hours, and 13% after 7 days. For 503 patients intubated and extubated in the cardiac operating room, 15 patients (3%) failed extubation within 48 hours (12 within 24 hr). Case-mix-adjusted extubation failure rates ranged from 1.1% to 9.8% across hospitals. Patients failing extubation had greater median cardiac ICU length of stay (15 vs 3 d; p < 0.001) and in-hospital mortality (7.9 vs 1.2%; p < 0.001). CONCLUSIONS Though extubation failure is uncommon overall, there may be opportunities to improve extubation readiness assessment in patients ventilated more than 24 hours. These data suggest that extubation in the operating room after cardiac surgery can be done with a low failure rate. We observed variation in extubation failure rates across hospitals, and future investigation must elucidate the optimal strategies of high-performing centers to reduce ventilation time while limiting extubation failures.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Other literature type . 2015
    Data sources: PubMed Central
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    https://pubmed.ncbi.nlm.nih.go...
    Other literature type . 2015
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    Authors: Poole, Russell;
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    Other literature type . 2007
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    Authors: Simpson, Erika; Langille, H. Peter;
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    Authors: Tao Shi; Hongwen Huang; Michael S. Barker;

    Background and aims To assess the number and phylogenetic distribution of large-scale genome duplications in the ancestry of Actinidia, publicly available expressed sequenced tags (ESTs) for members of the Actinidiaceae and related Ericales, including tea (Camellia sinensis), were analysed. Methods Synonymous divergences (K(s)) were calculated for all duplications within gene families and examined for evidence of large-scale duplication events. Phylogenetic comparisons for a selection of orthologues among several related species in Ericales and two outgroups permitted placement of duplication events in relation to lineage divergences. Gene ontology (GO) categories were analysed for each whole-genome duplication (WGD) and the whole transcriptome. Key results Evidence for three ancient WGDs in Actinidia was found. Analyses of paleologue GO categories indicated a different pattern of retained genes for each genome duplication, but a pattern consistent with the dosage-balance hypothesis among all retained paleologues. Conclusions This study provides evidence for one independent WGD in the ancestry of Actinidia (Ad-alpha), a WGD shared by Actinidia and Camellia (Ad-beta), and the well-established At-gamma WGD that occurred prior to the divergence of all taxa examined. More ESTs in other taxa are needed to elucidate which groups in Ericales share the Ad-beta or Ad-alpha duplications and their impact on diversification.

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    Europe PubMed Central
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    Annals of Botany
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    Annals of Botany
    Article . 2010
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    Authors: Administrator, UWindsor;
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    Authors: Tran, Hong Hanh;

    Virus-based expression systems have been widely exploited for the production of recombinant proteins in plants during the last three decades. Advances in technology have boosted scale-up manufacturing of plant-made pharmaceuticals to high levels, via the complementation of transient expression and viral vectors. This combination allows proteins of interest to be produced in plants within a matter of days and thus, is well suited for the development of plant-made vaccines or therapeutics against emerging infectious diseases and potential bioterrorism agents. Several plant-based products are currently in varying stages of clinical development. To investigate the viability of virus-based expression systems for plant-made subunit vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV), I have developed several viral vectors which express partial PRRSV glycoprotein 5 (GP5). In this thesis, I demonstrated that viral vectors can increase the expression of proteins for vaccine development in a variety of host plants. Green fluorescent protein (GFP) and the C-terminus of GP5 fused with GFP (GP5C-GFP) were expressed at up to 37.29 mg/kg and 4.36 mg/kg fresh weight of leaf tissue, respectively, in soybean plants via biolistic bombardment, using viral vectors derived from Bean pod mottle virus (BPMV). A Cucumber green mottle mosaic virus (CGMMV)-based vector was employed to display chimeric virus particles, presenting the neutralizing epitope (NE) of GP5, at levels as high as 35.84 mg/kg of cucumber leaf fresh weight, via agroinfiltration. In addition, GFP and the ectodomain of GP5 fused with GFP (GP5e-GFP) were successfully produced at up to 2.03 g/kg and 36.53 mg/kg fresh weight of leaf tissue, respectively, in Nicotiana benthamiana using transient expression of Pepino mosaic virus (PepMV)-based vectors. Co-infiltration of viral vectors with p19, a silencing suppressor, can help to mitigate the toxicity of GP5e to plant tissue and enhance the accumulation of this protein. These plant-made products may be tested as oral subunit vaccines against PRRSV in pigs during future experimental trials. Overall, the results demonstrate that viral systems can produce low-cost, versatile and robust vaccines that have a great impact in the fight against viral diseases, especially in developing countries.

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    Authors: J Johnson; David A. Case; T Yamazaki; Sergey Gusarov; +2 Authors

    Implicit solvent models offer an attractive way to estimate the effects of a solvent environment on the properties of small or large solutes without the complications of explicit simulations. One common test of accuracy is to compute the free energy of transfer from gas to liquid for a variety of small molecules, since many of these values have been measured. Studies of the temperature dependence of these values (i.e. solvation enthalpies and entropies) can provide additional insights into the performance of implicit solvent models. Here, we show how to compute temperature derivatives of hydration free energies for the 3D-RISM integral equation approach. We have computed hydration free energies of 1123 small drug-like molecules (both neutral and charged). Temperature derivatives were also used to calculate hydration energies and entropies of 74 of these molecules (both neutral and charged) for which experimental data is available. While direct results have rather poor agreement with experiment, we have found that several previously proposed linear hydration free energy correction schemes give good agreement with experiment. These corrections also provide good agreement for hydration energies and entropies though simple extensions are required in some cases.

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    Europe PubMed Central
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    Journal of Physics Condensed Matter
    Article . 2016
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      Europe PubMed Central
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      Journal of Physics Condensed Matter
      Article . 2016
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    Authors: Limic, Vlada; Sturm, Anja;

    This paper extends the notion of the $\la$-coalescent of Pitman (1999) to the spatial setting. The partition elements of the spatial $\Lambda$-coalescent migrate in a (finite) geographical space and may only coalesce if located at the same site of the space. We characterize the $\Lambda$-coalescents that come down from infinity, in an analogous way to Schweinsberg (2000). Surprisingly, all spatial coalescents that come down from infinity, also come down from infinity in a uniform way. This enables us to study space-time asymptotics of spatial $\Lambda$-coalescents on large tori in $d\ge 3$ dimensions. Our results generalize and strengthen those of Greven et al. (2005), who studied the spatial Kingman coalescent in this context. Comment: 29 pages

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    Electronic Journal of Probability
    Other literature type . 2006
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      Electronic Journal of Probability
      Other literature type . 2006
      Data sources: Project Euclid
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    Authors: Igue, Charlemagne Babatoundé;

    Cet article étudie le lien entre l’efficacité de l’intermédiation financière et la croissance économique sur un panel de sept pays de l’UEMOA** sur la période 1990-2008. Tout d’abord, un modèle théorique est présenté dans lequel l’efficacité de l’intermédiation bancaire renforce la croissance économique par le biais de l’amélioration de la productivité marginale du capital. Ensuite, l’efficacité du secteur bancaire est étudiée par le concept d’efficacité-X de Leibenstein (1966). Les scores d’efficacité bancaire sont estimés par la méthode DEA (Data Envelopment Analysis), appliquée à un modèle de production bancaire sur un échantillon de banques de l’UEMOA. Finalement, les scores moyens d’efficacité bancaire par pays sont calculés et utilisés comme indicateur de l’efficacité de l’intermédiation financière dans un modèle de croissance sur données de panel. Les résultats suggèrent l’existence d’une influence positive et significative de l’efficacité du secteur bancaire sur la croissance économique. This paper explores the connection between financial intermediation efficiency and economic growth on a panel of seven countries of WAEMU from 1990 to 2008. First, a theoretical model is presented in which financial efficiency enhances economic growth by means of increasing the marginal productivity of capital. Next, the banking sector efficiency is apprehended by the X-efficiency concept of Leibenstein (1966). Banking efficiency scores are estimated with Data Envelopment Analysis method, applied to banking production model on a sample of banks of the WAEMU. Finally, average scores of banking efficiency by country are calculated and used as indicator of financial intermediation efficiency in a growth model on panel data. Results suggest the existence of a positive impact of the banking sector efficiency on the economic growth.

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    L Actualité économique; Érudit
    Other literature type . Article . 2014
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      L Actualité économique; Érudit
      Other literature type . Article . 2014
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    Authors: Guéroult, Martial;