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1,043 Research products, page 1 of 105

  • Canada
  • Research data
  • 2017-2021
  • Dataset
  • Canadian Institutes of Health Research

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  • Research data . 2017
    Open Access
    Authors: 
    Mazo, Alexander;
    Project: CIHR

    Original images associated with MOLECULAR-CELL-D-16-01448R2.

  • Open Access
    Authors: 
    Mehdi, Ali; Cheishvili, David; Arakelian, Ani; Bismar, Tarek A.; Szyf, Moshe; Rabbani, Shafaat A.;
    Publisher: figshare
    Project: CIHR

    Additional file 3: Supplementary Table 2. List of the primers used for pyrosequencing and amplicon sequencing (Illumina MiSeq system).

  • Open Access
    Authors: 
    Hyshka, Elaine; Jalene Anderson-Baron; Kamagaju Karekezi; Belle-Isle, Lynne; Elliott, Richard; Pauly, Bernie; Strike, Carol; Asbridge, Mark; Dell, Colleen; McBride, Keely; +2 more
    Publisher: Figshare
    Project: CIHR

    Provincial and territorial policy documents and indicator scores; table contains all CHARPP indicator scores from 13 provincial and territorial harm reduction policy report cards. (XLSX 57Â kb)

  • Authors: 
    Dae-Kyum Kim; Knapp, Jennifer; Kuang, Da; Chawla, Aditya; Cassonnet, Patricia; Hunsang Lee; Dayag Sheykhkarimli; Payman Samavarchi-Tehrani; Abdouni, Hala; Ashyad Rayhan; +10 more
    Publisher: GSA Journals
    Project: EC | PREPARE (602525), CIHR

    Supplementary tables for "A comprehensive, flexible collection of SARS-CoV-2 coding regions"

  • Open Access
    Authors: 
    Wadsworth, Brennan J.; Decotret, Lisa R.; Villamil, Carlos; Yapp, Donald; Wilson, Don; Benard, Francois; McKenzie, Michael; Bennewith, Kevin L.;
    Publisher: Taylor & Francis
    Project: CIHR

    A common feature of solid tumours that are resistant to therapy is the presence of regions with low oxygen content (i.e., hypoxia). Oxygen electrode studies suggest that localized prostate adenocarcinoma is commonly hypoxic, although conflicting data have been reported between immunohistochemical detection of hypoxia-induced proteins in biopsy specimens and positron emission tomography (PET) imaging of 18F-labeled hypoxia reporters. Although the 2-nitroimidazole 18F-EF5 is well-established to label hypoxic tumour cells in pre-clinical tumour models and clinical trials of multiple primary tumour sites, it has yet to be tested in prostate cancer. The purpose of this study was to evaluate the feasibility of using 18F-EF5 to detect hypoxia in clinical prostate tumours. Patients with localized adenocarcinoma of the prostate were recruited for pre-treatment 18F-EF5 PET scans. Immunohistochemistry was conducted on diagnostic biopsies to assess the expression of glucose transporter 1 (GLUT1), osteopontin (OPN), and carbonic anhydrase IX (CAIX). Immunoreactivity scores of staining intensity and frequency were used to indicate the presence of tumour hypoxia. We found low tumour-to-muscle ratios of 18F-EF5 uptake that were not consistent with tumour hypoxia, causing early termination of the study. However, we observed GLUT1 and OPN expression in all prostate tumour biopsies, indicating the presence of hypoxia in all tumours. Our data do not support the use of 18F-EF5 PET to detect hypoxia in prostate adenocarcinoma, and suggest the use of immunohistochemistry to quantify expression of the hypoxia-inducible proteins GLUT1 and OPN as indications of prostate tumour hypoxia.

  • Open Access
    Authors: 
    Chen, Ying; Monaco, Simona; Crawford, Douglas J;
    Publisher: Wiley
    Project: CIHR

    Targets for goal-directed action can be encoded in allocentric coordinates (relative to another visual landmark), but it is not known how these are converted into egocentric commands for action. Here, we investigated this using a slow event-related fMRI paradigm, based on our previous behavioral finding that the Allocentric to Egocentric (Allo-Ego) conversion for reach is done at the first possible opportunity. Participants were asked to remember (and eventually reach toward) the location of a briefly presented target relative to another visual landmark. After a 1st memory delay, participants were forewarned by a verbal instruction if the landmark would reappear at the same location, (potentially allowing them to plan a reach following the auditory cue before the 2nd delay), or at a different location where they had to wait for the final landmark to be presented before response, and then reach toward the remembered target location. As predicted, participants showed landmark-centered directional selectivity in occipital-temporal cortex during the first memory delay, only developed egocentric directional selectivity in occipital-parietal cortex during the second delay for the “Same cue” task, and during response for the “Different cue” task. We then compared cortical activation between these two tasks at the times when the Allo-Ego conversion occurred, and found common activation in right precuneus, right pre-supplementary area and bilateral dorsal premotor cortex. These results confirm that the brain converts allocentric codes to egocentric plans at the first possible opportunity, and identify the four most likely candidate sites specific to the Allo-Ego transformation for reaches.

  • Authors: 
    Pharoah, PDP;
    Country: United Kingdom
    Project: NIH | Regulatory T Cell Functio... (5R01CA126841-04), NIH | CASE-CONTROL STUDY OF OVA... (1R01CA061132-01), NIH | UCLA Clinical and Transla... (5UL1TR000124-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN055424-007), NHMRC | Molecular Epidemiology of... (400281), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | USC COMPREHENSIVE CANCER ... (3P30CA014089-17S1), NIH | HEREDITARY BREAST CANCER-... (5R01CA058860-02), NIH | Inflammation and Ovarian ... (5R01CA095023-03), NIH | Premenopausal Hormone Lev... (5R01CA067262-08),...

    Genotype data and related phenotype data for Ovarian Cancer Association Consortium project investigating common variantion in GTPAse genes and ovarian cancer risk

  • Open Access
    Authors: 
    Aliakbar Khalili-Yazdi; Namjoshi, Sarita; Hackett, Jesse; Ghonaim, Nour; Shilton, Brian H.;
    Publisher: Wiley
    Project: CIHR , NSERC

    Peptides from a CNBr digest of signal-sequenceless maltose binding protein (MBP) were coupled to a surface plasmon resonance (SPR) chip. SecA-N95, SecA-N68, and SecA-DM (which consists of only the DEAD Motor domains, NBD1 and NBD2) bound to the immobilized peptides; ADP weakened the binding. SecA-DM, which lacks the “preprotein cross-linking domain” (PPXD), displayed the most extensive binding, while an MBP-PPXD chimera showed no binding, demonstrating that the PPXD does not contribute to the binding. The sequence specificity was characterized using oriented peptide libraries; these results enabled synthesis of a 20-residue peptide that was used to recapitulate the results obtained with MBP-derived peptides. The study shows there is a promiscuous and nucleotide-modulated peptide-binding site in the DEAD Motor domains of SecA.

  • Authors: 
    Rioux, Charlie; Stickley, Zachary L.; Little, Todd D.;
    Publisher: SAGE Journals
    Project: CIHR

    Supplemental Material, sj-r-1-jbd-10.1177_01650254211031631 for Solutions for latent growth modeling following COVID-19-related discontinuities in change and disruptions in longitudinal data collection by Charlie Rioux, Zachary L. Stickley and Todd D. Little in International Journal of Behavioral Development

  • Open Access
    Authors: 
    Cheung, Warren; Xiaojian Shao; Morin, Andréanne; Siroux, Valérie; Kwan, Tony; Ge, Bing; Aïssi, Dylan; Chen, Lu; Vasquez, Louella; Allum, Fiona; +23 more
    Publisher: Figshare
    Project: CIHR , WT , ANR | RESET-AID Consortium (ANR-15-EPIG-0004), UKRI | Study of the interplay of... (G0800270)

    Summary of AS and NAS methylation tests on the 2.2 million CpGs tested across any of the datasets. This file contains a file of tab-separated values (.txt text file) with the following columns: (1) CpG chromosome, (2) CpG location, (3) corrected GIT p value, (4) corrected mQTL p value, (5) corrected ASM p value, (6) ChromHMM state. (ZIP 19804 kb)

search
Include:
The following results are related to Canada. Are you interested to view more results? Visit OpenAIRE - Explore.
1,043 Research products, page 1 of 105
  • Research data . 2017
    Open Access
    Authors: 
    Mazo, Alexander;
    Project: CIHR

    Original images associated with MOLECULAR-CELL-D-16-01448R2.

  • Open Access
    Authors: 
    Mehdi, Ali; Cheishvili, David; Arakelian, Ani; Bismar, Tarek A.; Szyf, Moshe; Rabbani, Shafaat A.;
    Publisher: figshare
    Project: CIHR

    Additional file 3: Supplementary Table 2. List of the primers used for pyrosequencing and amplicon sequencing (Illumina MiSeq system).

  • Open Access
    Authors: 
    Hyshka, Elaine; Jalene Anderson-Baron; Kamagaju Karekezi; Belle-Isle, Lynne; Elliott, Richard; Pauly, Bernie; Strike, Carol; Asbridge, Mark; Dell, Colleen; McBride, Keely; +2 more
    Publisher: Figshare
    Project: CIHR

    Provincial and territorial policy documents and indicator scores; table contains all CHARPP indicator scores from 13 provincial and territorial harm reduction policy report cards. (XLSX 57Â kb)

  • Authors: 
    Dae-Kyum Kim; Knapp, Jennifer; Kuang, Da; Chawla, Aditya; Cassonnet, Patricia; Hunsang Lee; Dayag Sheykhkarimli; Payman Samavarchi-Tehrani; Abdouni, Hala; Ashyad Rayhan; +10 more
    Publisher: GSA Journals
    Project: EC | PREPARE (602525), CIHR

    Supplementary tables for "A comprehensive, flexible collection of SARS-CoV-2 coding regions"

  • Open Access
    Authors: 
    Wadsworth, Brennan J.; Decotret, Lisa R.; Villamil, Carlos; Yapp, Donald; Wilson, Don; Benard, Francois; McKenzie, Michael; Bennewith, Kevin L.;
    Publisher: Taylor & Francis
    Project: CIHR

    A common feature of solid tumours that are resistant to therapy is the presence of regions with low oxygen content (i.e., hypoxia). Oxygen electrode studies suggest that localized prostate adenocarcinoma is commonly hypoxic, although conflicting data have been reported between immunohistochemical detection of hypoxia-induced proteins in biopsy specimens and positron emission tomography (PET) imaging of 18F-labeled hypoxia reporters. Although the 2-nitroimidazole 18F-EF5 is well-established to label hypoxic tumour cells in pre-clinical tumour models and clinical trials of multiple primary tumour sites, it has yet to be tested in prostate cancer. The purpose of this study was to evaluate the feasibility of using 18F-EF5 to detect hypoxia in clinical prostate tumours. Patients with localized adenocarcinoma of the prostate were recruited for pre-treatment 18F-EF5 PET scans. Immunohistochemistry was conducted on diagnostic biopsies to assess the expression of glucose transporter 1 (GLUT1), osteopontin (OPN), and carbonic anhydrase IX (CAIX). Immunoreactivity scores of staining intensity and frequency were used to indicate the presence of tumour hypoxia. We found low tumour-to-muscle ratios of 18F-EF5 uptake that were not consistent with tumour hypoxia, causing early termination of the study. However, we observed GLUT1 and OPN expression in all prostate tumour biopsies, indicating the presence of hypoxia in all tumours. Our data do not support the use of 18F-EF5 PET to detect hypoxia in prostate adenocarcinoma, and suggest the use of immunohistochemistry to quantify expression of the hypoxia-inducible proteins GLUT1 and OPN as indications of prostate tumour hypoxia.

  • Open Access
    Authors: 
    Chen, Ying; Monaco, Simona; Crawford, Douglas J;
    Publisher: Wiley
    Project: CIHR

    Targets for goal-directed action can be encoded in allocentric coordinates (relative to another visual landmark), but it is not known how these are converted into egocentric commands for action. Here, we investigated this using a slow event-related fMRI paradigm, based on our previous behavioral finding that the Allocentric to Egocentric (Allo-Ego) conversion for reach is done at the first possible opportunity. Participants were asked to remember (and eventually reach toward) the location of a briefly presented target relative to another visual landmark. After a 1st memory delay, participants were forewarned by a verbal instruction if the landmark would reappear at the same location, (potentially allowing them to plan a reach following the auditory cue before the 2nd delay), or at a different location where they had to wait for the final landmark to be presented before response, and then reach toward the remembered target location. As predicted, participants showed landmark-centered directional selectivity in occipital-temporal cortex during the first memory delay, only developed egocentric directional selectivity in occipital-parietal cortex during the second delay for the “Same cue” task, and during response for the “Different cue” task. We then compared cortical activation between these two tasks at the times when the Allo-Ego conversion occurred, and found common activation in right precuneus, right pre-supplementary area and bilateral dorsal premotor cortex. These results confirm that the brain converts allocentric codes to egocentric plans at the first possible opportunity, and identify the four most likely candidate sites specific to the Allo-Ego transformation for reaches.

  • Authors: 
    Pharoah, PDP;
    Country: United Kingdom
    Project: NIH | Regulatory T Cell Functio... (5R01CA126841-04), NIH | CASE-CONTROL STUDY OF OVA... (1R01CA061132-01), NIH | UCLA Clinical and Transla... (5UL1TR000124-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN055424-007), NHMRC | Molecular Epidemiology of... (400281), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | USC COMPREHENSIVE CANCER ... (3P30CA014089-17S1), NIH | HEREDITARY BREAST CANCER-... (5R01CA058860-02), NIH | Inflammation and Ovarian ... (5R01CA095023-03), NIH | Premenopausal Hormone Lev... (5R01CA067262-08),...

    Genotype data and related phenotype data for Ovarian Cancer Association Consortium project investigating common variantion in GTPAse genes and ovarian cancer risk

  • Open Access
    Authors: 
    Aliakbar Khalili-Yazdi; Namjoshi, Sarita; Hackett, Jesse; Ghonaim, Nour; Shilton, Brian H.;
    Publisher: Wiley
    Project: CIHR , NSERC

    Peptides from a CNBr digest of signal-sequenceless maltose binding protein (MBP) were coupled to a surface plasmon resonance (SPR) chip. SecA-N95, SecA-N68, and SecA-DM (which consists of only the DEAD Motor domains, NBD1 and NBD2) bound to the immobilized peptides; ADP weakened the binding. SecA-DM, which lacks the “preprotein cross-linking domain” (PPXD), displayed the most extensive binding, while an MBP-PPXD chimera showed no binding, demonstrating that the PPXD does not contribute to the binding. The sequence specificity was characterized using oriented peptide libraries; these results enabled synthesis of a 20-residue peptide that was used to recapitulate the results obtained with MBP-derived peptides. The study shows there is a promiscuous and nucleotide-modulated peptide-binding site in the DEAD Motor domains of SecA.

  • Authors: 
    Rioux, Charlie; Stickley, Zachary L.; Little, Todd D.;
    Publisher: SAGE Journals
    Project: CIHR

    Supplemental Material, sj-r-1-jbd-10.1177_01650254211031631 for Solutions for latent growth modeling following COVID-19-related discontinuities in change and disruptions in longitudinal data collection by Charlie Rioux, Zachary L. Stickley and Todd D. Little in International Journal of Behavioral Development

  • Open Access
    Authors: 
    Cheung, Warren; Xiaojian Shao; Morin, Andréanne; Siroux, Valérie; Kwan, Tony; Ge, Bing; Aïssi, Dylan; Chen, Lu; Vasquez, Louella; Allum, Fiona; +23 more
    Publisher: Figshare
    Project: CIHR , WT , ANR | RESET-AID Consortium (ANR-15-EPIG-0004), UKRI | Study of the interplay of... (G0800270)

    Summary of AS and NAS methylation tests on the 2.2 million CpGs tested across any of the datasets. This file contains a file of tab-separated values (.txt text file) with the following columns: (1) CpG chromosome, (2) CpG location, (3) corrected GIT p value, (4) corrected mQTL p value, (5) corrected ASM p value, (6) ChromHMM state. (ZIP 19804 kb)