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20 research outcomes, page 1 of 2
  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: NIH | Structure-Function Invest... (5R01GM114640-02), NIH | Regulation and function o... (1R56AG048917-01), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), NIH | A New Pathway for Reversi... (1R01AG047131-01A1), NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | Inhibition of the tumor-p... (5R01CA172886-02), CIHR , NIH | GDF11: an age-variant hor... (1R56AG052979-01), NHMRC | Targeting Activins to tre... (1078907)

    Binding of GDF11 to the type I receptor ALK5. A, B, C Steady state analysis for SPR traces shown in Fig. 7b and calculated values. The maximum response at each concentration is plotted to a steady state binding equation using Biacore T200 Evaluation Software version 1.0...

  • research data . 2018
    Authors:
    Pharoah, PDP;
    Persistent Identifiers
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | UCLA Clinical and Transla... (5UL1TR000124-04), NIH | Haplotype-Based Genome Sc... (1R01CA114343-01A2), NIH | Shanghai Womens Health St... (1UM1CA182910-01), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | Genes, Hormones &Environm... (5R01CA054419-14), NHMRC | Molecular Epidemiology of... (400281), NIH | Genetic Variation in the ... (5R01CA122443-06), NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | RISK FACTORS AND PROGNOST... (1R01CA061107-01),...

    Genotype data and related phenotype data for Ovarian Cancer Association Consortium project investigating common variantion in GTPAse genes and ovarian cancer risk

  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: NIH | A New Pathway for Reversi... (1R01AG047131-01A1), CIHR , NIH | Regulation and function o... (1R56AG048917-01), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), NIH | Structure-Function Invest... (5R01GM114640-02), NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02), NHMRC | Targeting Activins to tre... (1078907)

    Potency of recombinant GDF8 and GDF11 from different sources. Luciferase reporter gene assay ((CAGA)12 promoter) following titration of GDF8 (blue) and GDF11 (orange) ligands in HEK293 cells. Luciferase activity was assessed 18–24 h post ligand treatment. The calculated...

  • research data . 2015
    Open Access
    Authors:
    Rudolph, Anja; Fasching, Peter; Behrens, Sabine; Eilber, Ursula; Bolla, Manjeet; Wang, Qin; Thompson, Deborah; Czene, Kamila; Brand, Judith; Jingmei Li; ...
    Persistent Identifiers
    Publisher: Figshare
    Project: EC | COGS (223175), NIH | Identifying Genes for Mam... (5R01CA128931-04), NIH | Elucidating Loci Involved... (5U19CA148537-02), NIH | Breast Cancer Family Regi... (5UM1CA164920-03), NIH | Follow-up of Ovarian Canc... (3U19CA148112-04S1), NIH | Discovery Expansion and R... (5U19CA148065-04), NHMRC | Risk and prognostic facto... (504711), NIH | Identifying and validatin... (5R01CA176785-05), NIH | A Mayo Cohort Study of Ma... (1R01CA097396-01A1), NIH | Multiethnic Cohort Study ... (5R37CA054281-13),...

    a Beta estimates for interaction between single nucleotide polymorphisms (SNPs) and use of hormone replacement therapy (MHT) on percent density and for association between SNP and percent density. b beta estimates for interaction between SNPs and use of MHT on dense are...

  • research data . 2020
    Open Access
    Authors:
    Bull, Caroline J.; Bell, Joshua A.; Murphy, Neil; Sanderson, Eleanor; Smith, George Davey; Timpson, Nicholas J.; Banbury, Barbara L.; Albanes, Demetrius; Berndt, Sonja I.; Bézieau, Stéphane; ...
    Publisher: figshare
    Project: NIH | Multiethnic Cohort Study ... (5R37CA054281-13), WT , NIH | Genomic Wide Association ... (7U01CA122839-03), NIH | Using Functional Data to ... (1R21CA191312-01), CIHR , NIH | MOFFITT CANCER CENTER SUP... (3P30CA076292-08S4), NIH | Hormones and Colon Cancer... (5R01CA076366-07), WT | The Avon Longitudinal Stu... (217065), NIH | Epigenetic Events and Col... (5R01CA151993-03), NIH | GENE-ENVIRONMENT INTERACT... (5U01AG018033-03),...

    Additional file 1: Table S1. Genetic variants used to instrument BMI, WHR and metabolites. Table S2. Assesment of instrument strength. Table S3. Colorectal cancer case distributions by study, sex and site. Table S4. LogOR colorectal cancer per SD higher BMI or WHR. Tabl...

  • research data . 2018
    Open Access
    Authors:
    Lee, Anna; Ewing, Adam; Ellrott, Kyle; Hu, Yin; Houlahan, Kathleen; J. Bare; Shadrielle Espiritu; Huang, Vincent; Dang, Kristen; Zechen Chong; ...
    Persistent Identifiers
    Publisher: figshare
    Project: NIH | UCSC-Buck Inst. Genome Da... (5U24CA143858-04), NIH | BIGDATA: Mid-Scale DCM: D... (5R01CA180778-05), CIHR , ARC | Discovery Early Career Re... (DE150101117), NSERC

    Table S2. All competition-phase submissions evaluated with fâ =â 100 and jâ >â 0. (XLS 43 kb)

  • research data . 2019
    Authors:
    Levy, Ofer;
    Persistent Identifiers
    Publisher: ImmPort
    Project: NHMRC | Development of statistica... (1087415), NIH | Dissecting the mechanism ... (1U01AI124284-01), NSERC , UKRI | IMPRINT: IMmunising PRegn... (MR/R005990/1), CIHR

    Systems Biology Characterization in Early Life

  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), CIHR , NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NIH | Regulation and function o... (1R56AG048917-01), NIH | Structure-Function Invest... (5R01GM114640-02), NIH | A New Pathway for Reversi... (1R01AG047131-01A1), NHMRC | Targeting Activins to tre... (1078907)

    Pulse-chase treatment with GDF8 or GDF11 reveals potency differences. A Short exposure to GDF11 results in a significantly enhanced SMAD3-dependent response compared to GDF8. The experimental design is such that the ligand was added to HEK293 cells stably transfected wi...

  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: NHMRC | Targeting Activins to tre... (1078907), CIHR , NIH | Structure-Function Invest... (5R01GM114640-02), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02), NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | Regulation and function o... (1R56AG048917-01), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NIH | A New Pathway for Reversi... (1R01AG047131-01A1)

    Purification and quantification of GDF8/GDF11 chimeric ligands. A, B Representation of purified protein from selected GDF8/GDF11 chimeras under non-reduced (A) and reduced (B) conditions (4–15% gradient gel). Chimeras or empty vector control were produced transiently us...

  • research data . 2018
    Open Access
    Authors:
    Lee, Anna; Ewing, Adam; Ellrott, Kyle; Hu, Yin; Houlahan, Kathleen; J. Bare; Shadrielle Espiritu; Huang, Vincent; Dang, Kristen; Zechen Chong; ...
    Persistent Identifiers
    Publisher: figshare
    Project: NIH | BIGDATA: Mid-Scale DCM: D... (5R01CA180778-05), NIH | UCSC-Buck Inst. Genome Da... (5U24CA143858-04), CIHR , ARC | Discovery Early Career Re... (DE150101117), NSERC

    Table S1. Challenge participation. (XLS 5 kb)

20 research outcomes, page 1 of 2