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11 research outcomes, page 1 of 2
  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: CIHR , NIH | A New Pathway for Reversi... (1R01AG047131-01A1), NIH | Structure-Function Invest... (5R01GM114640-02), NIH | Regulation and function o... (1R56AG048917-01), NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NHMRC | Targeting Activins to tre... (1078907), NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02)

    Binding of GDF11 to the type I receptor ALK5. A, B, C Steady state analysis for SPR traces shown in Fig. 7b and calculated values. The maximum response at each concentration is plotted to a steady state binding equation using Biacore T200 Evaluation Software version 1.0...

  • research data . Image . 2019
    Open Access
    Authors:
    Schrauben, Eric; Brahmdeep Saini; Darby, Jack; Soo, Jia; Lock, Mitchell; Stirrat, Elaine; Stortz, Greg; Sled, John; Morrison, Janna; Seed, Mike; ...
    Publisher: figshare
    Project: NHMRC | Understanding the consequ... (1066916), CIHR

    Movie 3. Animated particle traces in ventral view of cardiac structures in a sheep fetus, shown over two cardiac cycles. Traces are emitted from the ductus venosus (DV, red) and from the distal inferior vena cava (IVCd, blue). RV: right ventricle; LV: left ventricle; FO...

  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), CIHR , NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NHMRC | Targeting Activins to tre... (1078907), NIH | Regulation and function o... (1R56AG048917-01), NIH | A New Pathway for Reversi... (1R01AG047131-01A1), NIH | Structure-Function Invest... (5R01GM114640-02), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02)

    Potency of recombinant GDF8 and GDF11 from different sources. Luciferase reporter gene assay ((CAGA)12 promoter) following titration of GDF8 (blue) and GDF11 (orange) ligands in HEK293 cells. Luciferase activity was assessed 18–24 h post ligand treatment. The calculated...

  • research data . Image . 2019
    Open Access
    Authors:
    Schrauben, Eric; Brahmdeep Saini; Darby, Jack; Soo, Jia; Lock, Mitchell; Stirrat, Elaine; Stortz, Greg; Sled, John; Morrison, Janna; Seed, Mike; ...
    Publisher: figshare
    Project: NHMRC | Understanding the consequ... (1066916), CIHR

    Figure S3. Boxplot comparison between 2D PC MRI (blue boxes) and 4D flow MRI (black boxes) for each individual vessel. Greater underestimation of 4D flow MRI is seen in the DAo and DA. (TIF 1826â kb)

  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02), NIH | Regulation and function o... (1R56AG048917-01), NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NHMRC | Targeting Activins to tre... (1078907), CIHR , NIH | A New Pathway for Reversi... (1R01AG047131-01A1), NIH | Structure-Function Invest... (5R01GM114640-02)

    Pulse-chase treatment with GDF8 or GDF11 reveals potency differences. A Short exposure to GDF11 results in a significantly enhanced SMAD3-dependent response compared to GDF8. The experimental design is such that the ligand was added to HEK293 cells stably transfected wi...

  • research data . Image . 2019
    Open Access
    Authors:
    Schrauben, Eric; Brahmdeep Saini; Darby, Jack; Soo, Jia; Lock, Mitchell; Stirrat, Elaine; Stortz, Greg; Sled, John; Morrison, Janna; Seed, Mike; ...
    Publisher: figshare
    Project: NHMRC | Understanding the consequ... (1066916), CIHR

    Movie 2. Animated particle traces in an oblique ventral view, shown over two cardiac cycles. Particles are emitted from the superior vena cava (SVC, blue) and proximal inferior vena cava (IVCp, red). MPA: main pulmonary artery; AAo: ascending aorta. (GIF 5828â kb)

  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), CIHR , NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NHMRC | Targeting Activins to tre... (1078907), NIH | Regulation and function o... (1R56AG048917-01), NIH | A New Pathway for Reversi... (1R01AG047131-01A1), NIH | Structure-Function Invest... (5R01GM114640-02), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02)

    Purification and quantification of GDF8/GDF11 chimeric ligands. A, B Representation of purified protein from selected GDF8/GDF11 chimeras under non-reduced (A) and reduced (B) conditions (4–15% gradient gel). Chimeras or empty vector control were produced transiently us...

  • research data . Image . 2019
    Open Access
    Authors:
    Schrauben, Eric; Brahmdeep Saini; Darby, Jack; Soo, Jia; Lock, Mitchell; Stirrat, Elaine; Stortz, Greg; Sled, John; Morrison, Janna; Seed, Mike; ...
    Publisher: figshare
    Project: NHMRC | Understanding the consequ... (1066916), CIHR

    Figure S2. Linear regression (left) and Bland-Altman (right) analysis comparing 2D PC MRI and 4D flow MRI, with individual color-coded vessels across all subjects. (TIF 224â kb)

  • research data . Image . 2019
    Open Access
    Authors:
    Schrauben, Eric; Brahmdeep Saini; Darby, Jack; Soo, Jia; Lock, Mitchell; Stirrat, Elaine; Stortz, Greg; Sled, John; Morrison, Janna; Seed, Mike; ...
    Publisher: figshare
    Project: NHMRC | Understanding the consequ... (1066916), CIHR

    Figure S1. Normal course of fetal circulation with locations of conservation of mass calculation overlaid as colored segments: IVCp = RHV + DV + IVCd (yellow, n = 7); SVC + IVCp = MPA + FO (green, n = 4); MPA = DA + PBF (red, n = 4); IVCp = DAo (blue, n = 8). DV: ductus...

  • research data . Image . 2017
    Open Access
    Authors:
    Walker, Ryan; Czepnik, Magdalena; Goebel, Erich; McCoy, Jason; Vujic, Ana; Miook Cho; Juhyun Oh; Aykul, Senem; Walton, Kelly; Schang, Gauthier; ...
    Publisher: Figshare
    Project: CIHR , NIH | A New Pathway for Reversi... (1R01AG047131-01A1), NIH | Structure-Function Invest... (5R01GM114640-02), NIH | Inhibition of the tumor-p... (5R01CA172886-02), NIH | Ligand-Receptor Interacti... (2R01GM058670-06A3), NIH | Regulation and function o... (1R56AG048917-01), NIH | Cardiomyocyte Lineage and... (5R01AG040019-02), NIH | Circulating FSTL3 and Age... (7R03AG049657-03), NIH | GDF11: an age-variant hor... (1R56AG052979-01), NHMRC | Targeting Activins to tre... (1078907)

    Sequence alignment of human BMP2, GDF8, and GDF11. Gray bars above and below the sequence depict gross topology of the ligands. Residues that interact with the type I receptor (blue) and type II receptor (yellow) are shown on BMP2 based on the BMP2:ALK3:ActRIIA co-cryst...

11 research outcomes, page 1 of 2