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Figure S1. The genotype of NOD1/2 DKO mice. Genomic DNA from mice was amplified by PCR with specific primers to detect the disrupted sequences on a 1% agarose gel with a 100Â bp marker. First 5 bands are the KO mice and the last bands are the WT mice in A and B. NÂ =â 5/3 per group. (TIFF 12868 kb)

Table S3. Cis acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. (XLS 31 kb)

Table S5. Mediation analysis omnibus P values for the 19 meQTLs associated with serum cotinine levels. (XLS 33 kb)

Table S7. CpG sites showing significant (FDR pâ

Table S9. Literature search results for smoking EWAS. (XLS 9 kb)

Table S6. Transcription factor binding site information for 55 highlighted CpG sites based on ENCODE data. (XLS 96 kb)

Video S1. Patient 1 (age 4Â years old) demonstrates chorea of her head, upper and lower extremities characteristic of patients with ATP8A2 mutations. (MOV 7783 kb)

Table S2. SNPs in the 40 top genes significantly associated (FDR pâ

Table S10. Gene boundaries, based on Ensembl transcripts for the 40 genes highlighted in the EWAS. (XLS 10 kb)

Table S1. Gene network (IPA) and pathway analysis (Gene Ontology) of EWAS results. (XLS 3125 kb)