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Figure S1. The genotype of NOD1/2 DKO mice. Genomic DNA from mice was amplified by PCR with specific primers to detect the disrupted sequences on a 1% agarose gel with a 100Â bp marker. First 5 bands are the KO mice and the last bands are the WT mice in A and B. NÂ =â 5/3 per group. (TIFF 12868 kb)

Table S3. Cis acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. (XLS 31 kb)

Table S7. CpG sites showing significant (FDR pâ

Table S9. Literature search results for smoking EWAS. (XLS 9 kb)

Table S5. Mediation analysis omnibus P values for the 19 meQTLs associated with serum cotinine levels. (XLS 33 kb)

Table S1. Gene network (IPA) and pathway analysis (Gene Ontology) of EWAS results. (XLS 3125 kb)

Table S8. Results for CIT performed on DILGOM sample replicated CpG sites and SNPs associated with their methylation levels as well as cotinine levels. (XLS 10 kb)

Table S4. Trans acting methylation quantitative trait loci in the 40 genes highlighted in the EWAS. (XLS 687 kb)

Table S1. Exome sequencing of individuals with ATP8A2 mutations. (XLSX 11 kb)

Video S3. Patient 4 demonstrating dystonic posturing of her arms. (MOV 1273 kb)