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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    All set for college summer arts festival -- Choir in concert -- Open reading on Thursday -- Captain Cook film, lectures on Saturday -- New sawmill training program -- Salt Lake choir on Sunday -- Lunchtime theatre finale -- Man of la mancha starts -- Treat for gourmets -- New books here -- Revised gymnasium hours -- Fitness week April 17-22 -- New student council -- Art show extensive -- Beddows a winner -- Meet the artist - Jo Merrill https://viuspace.viu.ca/bitstream/handle/10613/636/MainlyMalApr10-78.pdf?sequence=3

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ VIUSpacearrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    VIUSpace
    2013
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ VIUSpacearrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      VIUSpace
      2013
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Aghanoori, MohamadReza;

    Background: There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of animal models of type 1 and type 2 diabetes exhibiting diabetic sensorimotor polyneuropathy (DSPN). We hypothesized that loss of direct insulin or insulin-like growth factor 1 (IGF-1) signaling in diabetes drives depression of AMPK activity and mitochondrial function, both contributing to development of DSPN. Methods: Age-matched control Sprague-Dawley rats and streptozotocin (STZ)-induced type 1 diabetic rats with/without IGF-1 therapy or insulin implants were used for in vivo studies. For in vitro studies, adult DRG neurons derived from control or STZ-diabetic rats were cultured under defined conditions and treated with/without IGF-1 or insulin. Activators or inhibitors targeting components of the insulin/IGF-1 signaling pathways were used to unravel the mechanism of insulin/IGF-1 action in DRG neurons. Results: Insulin increased Akt phosphorylation and neurite outgrowth, and augmented mitochondrial function in DRG cultures derived from control or type 1 diabetic rats. In STZ-diabetic rats insulin implants reversed thermal sensitivity, increased dermal nerve density and restored the expression/activity of respiratory chain proteins in DRG. Decreased expression of mRNAs for IGF-1, AMPKα2 and ATP5a1 (subunit of ATPase) occurred in DRG of diabetic vs. control rats. IGF-1 up-regulated mRNA levels of these genes in cultured DRG neurons from control or diabetic rats. IGF-1 elevation of mitochondrial function, mtDNA and neurite outgrowth was suppressed by inhibition of AMPK (via siRNA). IGF-1 therapy in diabetic rats reversed thermal hypoalgesia, raised corneal nerve density and prevented tricarboxylic acid (TCA) pathway metabolite build-up in the sciatic nerve. Endogenous IGF-1 gene expression in neurons of the DRG was suppressed by hyperglycemia and rescued by treatment with IGF-1 or the aldose reductase inhibitor, sorbinil. Transcription factors NFAT1 and CEBP-β bound to the IGF-1 promoter in DRG tissue at higher levels in control vs diabetic rats. Inhibition of endogenous IGF-1 down-regulated Akt S473 phosphorylation and background neurite outgrowth in cultured DRG neurons. Conclusions: Insulin/IGF-1 therapy elevates mitochondrial function via AMPK to drive axonal repair in DSPN. Downregulation of endogenous IGF-1 in DRG neurons in diabetes may contribute to the pathogenesis of DSPN.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ MSpace at the Univer...arrow_drop_down
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    Authors: Singh, Gurankit;

    There are numerous properties of biomaterials, existing in the nature which are still unknown to the scientific community. Different modifications to the biomaterials can unlock new properties of these materials. This leads to the development of whole new type of material which can be used as an alternative to the existing materials and contribute to wide range of new applications. Stimuli-responsive hydrogels are one of the best strategies for controlled drug delivery, tissue engineering and biosensing based applications. Here in we report, a novel pH-sensitive and biodegradable hydrogel systems based on the carboxymethyl chitosan (CMC). The mechanical property of CMC changes from acidic to basic medium. This property is the reversible sol-gel conversion (solution phase to gel phase) of CMC solution based on the pH changes, and it was used in this work to synthesize peel-able onion like multimembrane hydrogels for a controlled fluorescein drug delivery model to intestine in gastro-intestine systems. Dissolution rates of the hydrogels was altered by using different concentrations of CMC and different number of hydrogels layers. Furthermore, CMC was used as a novel 3D printable bioink for potential biomaterial-based applications. The resulting CMC 3D printed structures were further used as a real-time wireless biosensor and for designing microfluidic channels. The mechanical properties and characterization of the CMC were studied by using rheology tests, FT-IR and 1H NMR.

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    Malaspina collaborates with U. of A. on muscle oxygenation research -- Inge Bolin, applied anthropologist, making a difference -- House lotto & tree fest could earn $100,000 -- Malaspina launches governance website -- What's cooking in Cowichan? The cookbook -- Malaspina dental assistant program receives highest certification status -- Parksville/Qualicum contract report -- Malaspina people -- Ed tech: Media services + instructional computing = ETC -- Diesel finds a home -- Powell River campus opens golf season witha new fundraiser -- Free public lecture series -- Lecture by renowned ethnobotanist Wade Davis, Nanaimo campus theatre, Saturday February 15, 7:30 p.m. -- Malaspina diary -- McLotto winners https://viuspace.viu.ca/bitstream/handle/10613/918/MainlyMalJan%3aFeb-97.pdf?sequence=3

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    VIUSpace
    2013
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      VIUSpace
      2013
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Semnani, Mohammad;

    A new method for efficient calibration of complex hydrological models that combines Dynamically Dimensioned Search (DDS) global optimization algorithm with Global Sensitivity Analysis (GSA) methods is introduced. This approach, which is called sensitivity-informed DDS, utilizes sensitivity indices to increase the probability of perturbation for the most sensitive parameters, while giving low chance to least sensitive ones. This feature improves the efficiency and effectiveness of optimization by finding good quality solutions in a shorter time. Three different implementations of sensitivity-informed DDS are considered. The first approach is named as GSA↔DDS, in which GSA toolboxes (Morris or Sobol) are performed initially and throughout the optimization process to constantly update the sensitivity information. The second approach is called GSA→DDS. In this method, the GSA methods are only performed initially to include the results of GSA within optimization process. The final implementation is called VARS→DDS. In this method, to enhance the efficiency of sensitivity analysis and optimization, VARS toolbox is performed outside the optimization to provide the sensitivity information. The performances of GSA↔DDS, GSA→DDS and VARS→DDS are compared with original DDS by solving various optimization problems (test functions and model calibration case studies). According to the results, when calibrating complex hydrological models with enough computational budget, VARS→DDS is significantly more efficient and effective than original DDS. However, the results also show that GSA→DDS and GSA↔DDS methods do not substantially improve the convergence rate and the final best solution compared to DDS. Thus, VARS→DDS is the recommended approach for sensitivity-informed DDS in calibration of distributed and semi-distributed models, when enough computational resources are available.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ MSpace at the Univer...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kan's;

    Menu from Kan's restaurant in San Francisco, CA. Red wines, rose wines, white wines, Kan's wine feature, champagne and sparkling wines, Kan's appeteasers, Kan's exotic drinks. From the Imogene Lim restaurant menu collection https://viuspace.viu.ca/bitstream/handle/10613/2786/LimKan.pdf?sequence=4

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ VIUSpacearrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    VIUSpace
    2016
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ VIUSpacearrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      VIUSpace
      2016
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Marin Jimenez, Astrid Patricia;

    Cette recherche doctorale a exploré la co-création d'un jeu musical éducatif. Plus spécifiquement, elle a exploré cette activité pédagogique créative pour diversifier les approches pédagogiques qualifiées de créatives qui ont été documentées jusqu'à présent en musique, notamment en contexte extrascolaire. Pour ce faire, ce projet doctoral a été structuré autour de quatre objectifs : 1) documenter les activités mises en place et réalisées durant le processus de co-création d'un jeu musical éducatif avec un groupe de jeunes musiciens apprenant un instrument de musique en contexte extrascolaire; 2) décrire les habitudes créatives (Lucas, 2016) qui ont été sollicitées par les participants tout au long du processus de création de leur jeu musical éducatif; 3) décrire, à partir des 8 facteurs proposés par O'Neill (2013), l'engagement perçu et manifesté par les participants durant la co-création de leur jeu musical éducatif; et 4) porter un regard critique, basé sur les trois composantes d'une pédagogie créative (Lin, 2011), envers l'approche pédagogique créative que la chercheure a mis en œuvre pour réussir cette activité d'apprentissage avec les participants. Un total de sept jeunes musiciens apprenant divers instruments musicaux (ex. : piano, guitare, violon, violoncelle) ont participé aux dix séances animées par la chercheure pour co-créer leur jeu musical éducatif. Différents outils de collecte de données ont été utilisés pour documenter ce projet : des enregistrements vidéo des séances, des observations, un questionnaire sur l'engagement envers l'activité réalisée (O'Neill, 2013), et un entretien de groupe pour approfondir la compréhension de l'activité d'apprentissage étudiée. Les résultats issus de ce projet de recherche ont mis en lumière que l'activité de co-création du jeu musical éducatif réalisé par les participants a fait appel aux trois composantes de la pédagogie créative de Lin (2011), soit l'enseignement créatif et l'enseignement pour la créativité dans la pédagogie de la chercheure, et l'apprentissage créatif des participants. Concernant leur apprentissage créatif, nos résultats ont mis en évidence que chacune des phases liées à la co-création d'un jeu musical éducatif (orientation, création, gameplay) ont fait appel aux cinq dimensions créatives suggérées par Lucas (2016) (ex. : être collaboratif, être imaginatif, être discipliné, être persistant, et être curieux), mais de façon différente selon le type d'activités réalisées et de la phase de co-création à laquelle les participants travaillaient. Quant à l'engagement des participants, nos résultats ont permis de relever que les 8 facteurs proposés par O'Neill (2013) ont soutenu, à des degrés divers toutefois, l'engagement perçu par nos participants. À ce titre, le facteur en lien avec les défis perçus durant la co-création d'un jeu musical éducatif a été celui qui a le plus contribué à soutenir leur engagement envers cette activité d'apprentissage. Nos observations des enregistrements vidéo ainsi que l'entretien de groupe réalisé à la fin du projet ont permis d'identifier et de décrire les moments où les participants ont manifesté leur engagement durant la création de leur jeu, c'est-à-dire lorsqu'ils restaient concentrés sur la tâche qu'ils réalisaient, lorsqu'ils manifestaient leur appréciation envers la tâche réalisée et les apprentissages acquis, ou lorsqu'ils persévéraient face à des difficultés, entre autres exemples. Par ailleurs, les réflexions critiques de la chercheure sur sa pédagogie ont fait ressortir que ses expériences précédentes en tant qu'enseignante du violon et d'auxiliaire de recherche ont possiblement influencé ses choix d'alignement d'apprentissages (Jones, 2005) tout au long du processus de co-création avec les participants, notamment en démontrant une préférence envers des approches pédagogiques moins hiérarchiques (midwife, fellow traveller). De plus, sa réflexion a relevé que les stratégies pédagogiques qui ont été plus efficaces pour co-créer le jeu musical éducatif ont été celles qui reflétaient une interconnexion entre les trois composantes de la pédagogie créative (Lin, 2011). À titre d'exemple, cette interconnexion se manifestait lorsque l'activité réalisée faisait appel à la créativité des participants (enseignement créatif), à l'aide d'une attitude ouverte et flexible de sa part (enseignement pour la créativité), laquelle entraîne à une expérience d'apprentissage créatif des participants. Finalement, l'intervention pédagogique implémentée par la chercheure a permis d'identifier les aspects liés aux modèles éducatifs, opérationnels et conceptuels utilisés pour mener son intervention éducative. Ces modèles ont été nécessaires pour établir les fondements pédagogiques qui se sont avérés pertinents pour structurer son activité d'apprentissage autour de la co-création d'un jeu musical éducatif. This doctoral research explored the co-creation of an educational music game as a pedagogical activity that could diversify the creative pedagogy approaches (Lin, 2011) documented to date in music, particularly in out-of-school settings. To that end, this research project was structured around four objectives: 1) to document, supported by the Creative and Playful Learning model (Kangas, 2010), the activities that were necessary to successfully complete the process of co-creating a music learning game with a group of young musicians (10-14 years old); 2) to describe the creative dimensions (Lucas, 2016) that were called upon by the participants throughout the process; 3) to describe, based on O'Neill's (2013) eight factors of engagement, the perceived and demonstrated engagement of the participants during the co-creation of their music learning game; and 4) to take a critical look, based on the three components of a creative pedagogy (Lin, 2011), towards the creative pedagogical approach the researcher implemented to successfully complete this learning activity with the participants. A total of seven young musicians learning a musical instrument (e.g., piano, guitar, violin, or cello) in an out-of-school context participated in ten music-learning-game-co-creation sessions facilitated by the researcher. Various data collection tools were used, including video recordings of the sessions, observations, an engagement questionnaire (O'Neill, 2013), and a group interview. The findings from this research project highlighted that the process of co-creating a music learning game put into action the three components of a creative pedagogy (Lin, 2011), notably creative teaching and teaching for creativity (in the researcher), and creative learning (in the participants). In relation to creative learning our results highlight that each of the phases related to co-creating an educational music game (i.e., orientation, creation, gameplay) called upon participants' five creative dimensions (e.g., being collaborative, being imaginative, being disciplined, being persistent, and being curious) (Lucas, 2016) in particular ways, depending on the type of activities performed during each phase. Regarding participants' engagement, our results allowed us to identify the eight factors (O'Neill, 2013) that contributed, to varying degrees, to sustaining participants' perceived engagement. As an example, the factor related to the perceived challenges during the co-creation of a music learning game was the factor that contributed the most to sustaining participants' engagement towards this learning activity. In contrast, the lack of perceived support from a teammate as well as the participants' instrument teachers was the factor that least supported participants engagement in this activity. Also, our observations and the group interview allowed us to identify and describe the moments where participants seemed to manifest their engagement during the creation of their game. For example, by remaining focused on the task, by verbally showing an appreciation for the task and the learning acquired, by persevering during difficulties and challenges, among other examples. In addition, the researcher's critical reflections noted that her previous experiences as a violin teacher and research assistant may have influenced her choices of learning alignments (Jones, 2005) throughout the co-creation process with the participants, notably a preference for less hierarchical pedagogical approaches (i.e., midwife, fellow traveler). Also, her reflection noted that the most effective pedagogical strategies were those that reflected an interconnectedness between the three components of creative pedagogy (Lin, 2011). Specifically, when the activity being conducted called upon students' creativity (creative teaching) and was well supported by an open and flexible attitude on her part (teaching for creativity), this resulted in a creative learning experience for the participants. In contrast, the less effective strategies were those that reflected a lack of connection among these components, either when she adopted an invasive attitude that did not respect the autonomy of the participants (i.e., less effective teaching for creativity that affects creative learning) or when the way that an activity was carried out did not maximize the intended opportunities for creative expression (i.e.: less effective creative teaching that results in less creative learning). Finally, the pedagogical intervention implemented by the researcher allowed us to identify the set of educational, operational, and conceptual models (e.g., Jones, 2005; Lin, 2011; Lucas, 2016 and O'Neill, 2013) that allowed us to establish the pedagogical foundations to structure a learning activity based on the co-creation of music learning games.

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    CorpusUL
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    Authors: Lescouët, Emmanuelle;
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    Authors: Swallow, Michelle;

    The Mackenzie River system is an important feature of the Northwest Territories (NWT). Students in the NWT schools could benefit from the support of curriculum resources to develop their knowledge about the Mackenzie River. Using the process of Human-Centred Design as a theoretical framework, I interviewed ten NWT teachers as potential end users of an online resource for learning about the Mackenzie River. The data from the teacher interviews was used to create a list of design criteria for a website-based educational resource on the Mackenzie River. In partnership with the Northwest Territories Department of Education, Culture and Employment and the Prince of Wales Northern Heritage Centre (PWNHC), I created a prototype website in which students can make a virtual river journey while meeting the requirements of the Grade 4 curriculum. The teachers who were originally interviewed then reviewed the prototype and made further recommendations for a final version of the website.

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    VIUSpace
    2016
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      VIUSpace
      2016
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    Authors: Grand Star;

    Menu from Grand Star restaurant in Los Angeles, CA. Chinese family style dinner, special Chinese style lunch, soups, complete fountain beverages, chicken chop suey, pork chop suey, rice, chow mein, boiled noodles, eggs. From the Imogene Lim restaurant menu collection https://viuspace.viu.ca/bitstream/handle/10613/2711/LimGrand.pdf?sequence=4

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    VIUSpace
    2016
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      VIUSpace
      2016
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21,743 Research products
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    All set for college summer arts festival -- Choir in concert -- Open reading on Thursday -- Captain Cook film, lectures on Saturday -- New sawmill training program -- Salt Lake choir on Sunday -- Lunchtime theatre finale -- Man of la mancha starts -- Treat for gourmets -- New books here -- Revised gymnasium hours -- Fitness week April 17-22 -- New student council -- Art show extensive -- Beddows a winner -- Meet the artist - Jo Merrill https://viuspace.viu.ca/bitstream/handle/10613/636/MainlyMalApr10-78.pdf?sequence=3

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    VIUSpace
    2013
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      VIUSpace
      2013
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Aghanoori, MohamadReza;

    Background: There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of animal models of type 1 and type 2 diabetes exhibiting diabetic sensorimotor polyneuropathy (DSPN). We hypothesized that loss of direct insulin or insulin-like growth factor 1 (IGF-1) signaling in diabetes drives depression of AMPK activity and mitochondrial function, both contributing to development of DSPN. Methods: Age-matched control Sprague-Dawley rats and streptozotocin (STZ)-induced type 1 diabetic rats with/without IGF-1 therapy or insulin implants were used for in vivo studies. For in vitro studies, adult DRG neurons derived from control or STZ-diabetic rats were cultured under defined conditions and treated with/without IGF-1 or insulin. Activators or inhibitors targeting components of the insulin/IGF-1 signaling pathways were used to unravel the mechanism of insulin/IGF-1 action in DRG neurons. Results: Insulin increased Akt phosphorylation and neurite outgrowth, and augmented mitochondrial function in DRG cultures derived from control or type 1 diabetic rats. In STZ-diabetic rats insulin implants reversed thermal sensitivity, increased dermal nerve density and restored the expression/activity of respiratory chain proteins in DRG. Decreased expression of mRNAs for IGF-1, AMPKα2 and ATP5a1 (subunit of ATPase) occurred in DRG of diabetic vs. control rats. IGF-1 up-regulated mRNA levels of these genes in cultured DRG neurons from control or diabetic rats. IGF-1 elevation of mitochondrial function, mtDNA and neurite outgrowth was suppressed by inhibition of AMPK (via siRNA). IGF-1 therapy in diabetic rats reversed thermal hypoalgesia, raised corneal nerve density and prevented tricarboxylic acid (TCA) pathway metabolite build-up in the sciatic nerve. Endogenous IGF-1 gene expression in neurons of the DRG was suppressed by hyperglycemia and rescued by treatment with IGF-1 or the aldose reductase inhibitor, sorbinil. Transcription factors NFAT1 and CEBP-β bound to the IGF-1 promoter in DRG tissue at higher levels in control vs diabetic rats. Inhibition of endogenous IGF-1 down-regulated Akt S473 phosphorylation and background neurite outgrowth in cultured DRG neurons. Conclusions: Insulin/IGF-1 therapy elevates mitochondrial function via AMPK to drive axonal repair in DSPN. Downregulation of endogenous IGF-1 in DRG neurons in diabetes may contribute to the pathogenesis of DSPN.

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    Authors: Singh, Gurankit;

    There are numerous properties of biomaterials, existing in the nature which are still unknown to the scientific community. Different modifications to the biomaterials can unlock new properties of these materials. This leads to the development of whole new type of material which can be used as an alternative to the existing materials and contribute to wide range of new applications. Stimuli-responsive hydrogels are one of the best strategies for controlled drug delivery, tissue engineering and biosensing based applications. Here in we report, a novel pH-sensitive and biodegradable hydrogel systems based on the carboxymethyl chitosan (CMC). The mechanical property of CMC changes from acidic to basic medium. This property is the reversible sol-gel conversion (solution phase to gel phase) of CMC solution based on the pH changes, and it was used in this work to synthesize peel-able onion like multimembrane hydrogels for a controlled fluorescein drug delivery model to intestine in gastro-intestine systems. Dissolution rates of the hydrogels was altered by using different concentrations of CMC and different number of hydrogels layers. Furthermore, CMC was used as a novel 3D printable bioink for potential biomaterial-based applications. The resulting CMC 3D printed structures were further used as a real-time wireless biosensor and for designing microfluidic channels. The mechanical properties and characterization of the CMC were studied by using rheology tests, FT-IR and 1H NMR.

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    Malaspina collaborates with U. of A. on muscle oxygenation research -- Inge Bolin, applied anthropologist, making a difference -- House lotto & tree fest could earn $100,000 -- Malaspina launches governance website -- What's cooking in Cowichan? The cookbook -- Malaspina dental assistant program receives highest certification status -- Parksville/Qualicum contract report -- Malaspina people -- Ed tech: Media services + instructional computing = ETC -- Diesel finds a home -- Powell River campus opens golf season witha new fundraiser -- Free public lecture series -- Lecture by renowned ethnobotanist Wade Davis, Nanaimo campus theatre, Saturday February 15, 7:30 p.m. -- Malaspina diary -- McLotto winners https://viuspace.viu.ca/bitstream/handle/10613/918/MainlyMalJan%3aFeb-97.pdf?sequence=3

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    VIUSpace
    2013
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      VIUSpace
      2013
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    Authors: Semnani, Mohammad;

    A new method for efficient calibration of complex hydrological models that combines Dynamically Dimensioned Search (DDS) global optimization algorithm with Global Sensitivity Analysis (GSA) methods is introduced. This approach, which is called sensitivity-informed DDS, utilizes sensitivity indices to increase the probability of perturbation for the most sensitive parameters, while giving low chance to least sensitive ones. This feature improves the efficiency and effectiveness of optimization by finding good quality solutions in a shorter time. Three different implementations of sensitivity-informed DDS are considered. The first approach is named as GSA↔DDS, in which GSA toolboxes (Morris or Sobol) are performed initially and throughout the optimization process to constantly update the sensitivity information. The second approach is called GSA→DDS. In this method, the GSA methods are only performed initially to include the results of GSA within optimization process. The final implementation is called VARS→DDS. In this method, to enhance the efficiency of sensitivity analysis and optimization, VARS toolbox is performed outside the optimization to provide the sensitivity information. The performances of GSA↔DDS, GSA→DDS and VARS→DDS are compared with original DDS by solving various optimization problems (test functions and model calibration case studies). According to the results, when calibrating complex hydrological models with enough computational budget, VARS→DDS is significantly more efficient and effective than original DDS. However, the results also show that GSA→DDS and GSA↔DDS methods do not substantially improve the convergence rate and the final best solution compared to DDS. Thus, VARS→DDS is the recommended approach for sensitivity-informed DDS in calibration of distributed and semi-distributed models, when enough computational resources are available.

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    Authors: Kan's;

    Menu from Kan's restaurant in San Francisco, CA. Red wines, rose wines, white wines, Kan's wine feature, champagne and sparkling wines, Kan's appeteasers, Kan's exotic drinks. From the Imogene Lim restaurant menu collection https://viuspace.viu.ca/bitstream/handle/10613/2786/LimKan.pdf?sequence=4

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    VIUSpace
    2016
    Data sources: VIUSpace
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ VIUSpacearrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      VIUSpace
      2016
      Data sources: VIUSpace
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