434 Research products, page 1 of 44
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- Other research product . 1894Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/19841/Aug24-1894.pdf?sequence=2
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1921Open Access English
https://viurrspace.ca/bitstream/handle/10613/12338/Mar17-1921.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCID
Please grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 1917Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/15057/Oct18-1917.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1874Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/19025/Dec26-1874.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1890Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/21173/Nov14-1890.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . Other ORP type . 2020Open Access EnglishAuthors:Holstege, Henne; Grozeva, Detelina; Sims, Rebecca; Luckcuck, Lauren; Denning, Nicola; Marshall, Rachel; Saad, Salha; Williams, Julie; Meggy, Alun; Lambert, Jean-Charles; +79 moreHolstege, Henne; Grozeva, Detelina; Sims, Rebecca; Luckcuck, Lauren; Denning, Nicola; Marshall, Rachel; Saad, Salha; Williams, Julie; Meggy, Alun; Lambert, Jean-Charles; Hulsman, M.; Charbonnier, C.; Grenier-Boley, B.; Quenez, O.; van Rooij, J.; Ahmad, S.; Amin, N.; Norsworthy, P.; Dols, O.; Hummerich, H.; Kawalia, A.; Amouyel, P.; Beecham, G.; Berr, C.; Bis, J.; Boland, A.; Bossu, P.; Bouwman, F.; Campion, D.; Daniele, A.; Dartigues, J. F.; Debette, S.; Deleuze, J. F.; Destefano, A.; Farrer, L.; Fox, N.; Glimberti, D.; Genin, E.; Haines, J.; Holmes, C.; Arfan Ikram, M.; Ikram, M.; Jansen, I.; Kraaij, R.; Lathrop, M.; Lemstra, A.; Lleo, A.; Luckcuck, L.; Marschall, R.; Martin, E.; Masullo, C.; Mayeux, R.; Mecocci, P.; Mol, M.; Morgan, K.; Nacmia, B.; Naj, A.; Pastor, P.; Pericak-Vance, M.; Redon, R; Richard, A. C.; Riedel-Heller, S.; Rivadeneira, F.; Rousseau, S.; Ryan, N.; Sanchez-Juan, P.; Schellenberg, G.; Scheltens, P.; Scott, J.; Seripa, D.; Spalletta, G.; Tijms, B.; Uitterlinden, A.; van der Lee, S.; Wagner, M.; Wallon, D.; Wang, L. S.; Zarea, A.; Reinders, M.; Clarimon, J.; van Swieten, J.; Hardy, J.; Ramirez, A.; Mead, S. H.; van der Flier, W.; van Duijn, C.; Nicolas, G.; Bellenguez, C.; Lambert, J. C.;Publisher: medRxivProject: NIH | DATA MANAGEMENT AND BIOST... (5P50AG023501-03), NIH | Replication and Extension... (3U01AG052410-04S1), NIH | Gene discovery in PSP by ... (3R01NS080820-02S1), EC | ENGAGE (201413), NIH | CHS-Transition Phase -268... (N01HC055222-001), NIH | ALZHEIMERS DISEASE DATA C... (5U01AG016976-03), NIH | GENETIC EPIDEMIOLOGICAL S... (5R01AG009029-03), NWO | NCHA Subsidiebesluit 2008... (050-060-810), NIH | UC Davis Alzheimer's Core... (3P30AG010129-28S1), NIH | Large Scale Sequencing an... (3U54HG003067-07S1),...
The genetic component of Alzheimer’s disease (AD) has been mainly assessed using Genome Wide Association Studies (GWAS), which do not capture the risk contributed by rare variants. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals —16,036 AD cases and 16,522 controls— in a two-stage analysis. Next to known genes TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Next to these genes, the rare variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential driver genes in AD-GWAS loci. Rare damaging variants in these genes, and in particular loss-of-function variants, have a large effect on AD-risk, and they are enriched in early onset AD cases. The newly identified AD-associated genes provide additional evidence for a major role for APP-processing, Aβ-aggregation, lipid metabolism and microglial function in AD.
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1892Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/21199/Feb23-1892.pdf?sequence=2
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . Lecture . 2012Open Access EnglishAuthors:Quené, H.; Schuerman, W.L.;Quené, H.; Schuerman, W.L.;Country: Netherlands
Smiling during talking yields speech with higher formants, and hence larger formant dispersion. Previous studies have shown that motor resonance during perception of words related to smiling can activate muscles responsible for the smiling action. If word perception causes smiling activation for such smile-related words, then this motor resonance may occur also during production, resulting in larger formant dispersion in these smile-related words. This paper reports on formant measurements from tokens of the Corpus of Spoken Dutch. Formant values of smile-related word tokens were compared to semantically different but phonetically similar word tokens. Results suggest that formant dispersion is indeed larger in smile-related words than in control words, although the predicted difference was observed only for female speakers. These findings suggest that motor resonance originating from a word's meaning may affect the articulatory and acoustic realization of affective spoken words. Female speakers tend to produce the word "smile" with a smile.
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1881Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/22009/Jan05-1881.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1886Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/22550/Mar24-1886.pdf?sequence=2
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.
434 Research products, page 1 of 44
Loading
- Other research product . 1894Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/19841/Aug24-1894.pdf?sequence=2
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1921Open Access English
https://viurrspace.ca/bitstream/handle/10613/12338/Mar17-1921.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCID Please grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Other research product . 1917Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/15057/Oct18-1917.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1874Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/19025/Dec26-1874.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1890Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/21173/Nov14-1890.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . Other ORP type . 2020Open Access EnglishAuthors:Holstege, Henne; Grozeva, Detelina; Sims, Rebecca; Luckcuck, Lauren; Denning, Nicola; Marshall, Rachel; Saad, Salha; Williams, Julie; Meggy, Alun; Lambert, Jean-Charles; +79 moreHolstege, Henne; Grozeva, Detelina; Sims, Rebecca; Luckcuck, Lauren; Denning, Nicola; Marshall, Rachel; Saad, Salha; Williams, Julie; Meggy, Alun; Lambert, Jean-Charles; Hulsman, M.; Charbonnier, C.; Grenier-Boley, B.; Quenez, O.; van Rooij, J.; Ahmad, S.; Amin, N.; Norsworthy, P.; Dols, O.; Hummerich, H.; Kawalia, A.; Amouyel, P.; Beecham, G.; Berr, C.; Bis, J.; Boland, A.; Bossu, P.; Bouwman, F.; Campion, D.; Daniele, A.; Dartigues, J. F.; Debette, S.; Deleuze, J. F.; Destefano, A.; Farrer, L.; Fox, N.; Glimberti, D.; Genin, E.; Haines, J.; Holmes, C.; Arfan Ikram, M.; Ikram, M.; Jansen, I.; Kraaij, R.; Lathrop, M.; Lemstra, A.; Lleo, A.; Luckcuck, L.; Marschall, R.; Martin, E.; Masullo, C.; Mayeux, R.; Mecocci, P.; Mol, M.; Morgan, K.; Nacmia, B.; Naj, A.; Pastor, P.; Pericak-Vance, M.; Redon, R; Richard, A. C.; Riedel-Heller, S.; Rivadeneira, F.; Rousseau, S.; Ryan, N.; Sanchez-Juan, P.; Schellenberg, G.; Scheltens, P.; Scott, J.; Seripa, D.; Spalletta, G.; Tijms, B.; Uitterlinden, A.; van der Lee, S.; Wagner, M.; Wallon, D.; Wang, L. S.; Zarea, A.; Reinders, M.; Clarimon, J.; van Swieten, J.; Hardy, J.; Ramirez, A.; Mead, S. H.; van der Flier, W.; van Duijn, C.; Nicolas, G.; Bellenguez, C.; Lambert, J. C.;Publisher: medRxivProject: NIH | DATA MANAGEMENT AND BIOST... (5P50AG023501-03), NIH | Replication and Extension... (3U01AG052410-04S1), NIH | Gene discovery in PSP by ... (3R01NS080820-02S1), EC | ENGAGE (201413), NIH | CHS-Transition Phase -268... (N01HC055222-001), NIH | ALZHEIMERS DISEASE DATA C... (5U01AG016976-03), NIH | GENETIC EPIDEMIOLOGICAL S... (5R01AG009029-03), NWO | NCHA Subsidiebesluit 2008... (050-060-810), NIH | UC Davis Alzheimer's Core... (3P30AG010129-28S1), NIH | Large Scale Sequencing an... (3U54HG003067-07S1),...
The genetic component of Alzheimer’s disease (AD) has been mainly assessed using Genome Wide Association Studies (GWAS), which do not capture the risk contributed by rare variants. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals —16,036 AD cases and 16,522 controls— in a two-stage analysis. Next to known genes TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Next to these genes, the rare variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential driver genes in AD-GWAS loci. Rare damaging variants in these genes, and in particular loss-of-function variants, have a large effect on AD-risk, and they are enriched in early onset AD cases. The newly identified AD-associated genes provide additional evidence for a major role for APP-processing, Aβ-aggregation, lipid metabolism and microglial function in AD.
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1892Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/21199/Feb23-1892.pdf?sequence=2
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . Lecture . 2012Open Access EnglishAuthors:Quené, H.; Schuerman, W.L.;Quené, H.; Schuerman, W.L.;Country: Netherlands
Smiling during talking yields speech with higher formants, and hence larger formant dispersion. Previous studies have shown that motor resonance during perception of words related to smiling can activate muscles responsible for the smiling action. If word perception causes smiling activation for such smile-related words, then this motor resonance may occur also during production, resulting in larger formant dispersion in these smile-related words. This paper reports on formant measurements from tokens of the Corpus of Spoken Dutch. Formant values of smile-related word tokens were compared to semantically different but phonetically similar word tokens. Results suggest that formant dispersion is indeed larger in smile-related words than in control words, although the predicted difference was observed only for female speakers. These findings suggest that motor resonance originating from a word's meaning may affect the articulatory and acoustic realization of affective spoken words. Female speakers tend to produce the word "smile" with a smile.
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1881Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/22009/Jan05-1881.pdf?sequence=2&isAllowed=y
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact. - Other research product . 1886Open Access EnglishPublisher: Nanaimo Free PressCountry: Canada
https://viurrspace.ca/bitstream/handle/10613/22550/Mar24-1886.pdf?sequence=2
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.