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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Claes Nøhr Ladefoged; Ian Law; Udunna C. Anazodo; Keith St. Lawrence; +24 Authors

    Aim: To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the current vendor-implemented MR-AC methods for absolute quantification, a number of prototype methods have been proposed in the literature. These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based. These proposed methods in general demonstrated improvements compared to vendor-implemented AC, and many studies report deviations in PET uptake after AC of only a few percent from a gold standard CT-AC. Using a unified quantitative evaluation with identical metrics, subject cohort, and common CT-based reference, the aims of this study were to evaluate a selection of novel methods proposed in the literature, and identify the ones suitable for clinical use. Methods: In total, 11 AC methods were evaluated: two vendor-implemented (MR-ACDIXON and MR-ACUTE), five based on template/atlas information (MR-ACSEGBONE (Koesters et al., 2016), MR-ACONTARIO (Anazodo et al., 2014), MR-ACBOSTON (Izquierdo-Garcia et al., 2014), MR-ACUCL (Burgos et al., 2014), and MR-ACMAXPROB (Merida et al., 2015)), one based on simultaneous reconstruction of attenuation and emission (MR-ACMLAA (Benoit et al., 2015)), and three based on image-segmentation (MR-ACMUNICH (Cabello et al., 2015), MR-ACCAR-RiDR (Juttukonda et al., 2015), and MR-ACRESOLUTE (Ladefoged et al., 2015)). We selected 359 subjects who were scanned using one of the following radiotracers: [18F]FDG (210), [11C]PiB (51), and [18F]florbetapir (98). The comparison to AC with a gold standard CT was performed both globally and regionally, with a special focus on robustness and outlier analysis. Results: The average performance in PET tracer uptake was within ±5% of CT for all of the proposed methods, with the average±SD global percentage bias in PET FDG uptake for each method being: MR-ACDIXON (−11.3±3.5)%, MR-ACUTE (−5.7±2.0)%, MR-ACONTARIO (−4.3±3.6)%, MR-ACMUNICH (3.7±2.1)%, MR-ACMLAA (−1.9±2.6)%, MR-ACSEGBONE (−1.7±3.6)%, MR-ACUCL (0.8±1.2)%, MR-ACCAR-RiDR (−0.4±1.9)%, MR-ACMAXPROB (−0.4±1.6)%, MR-ACBOSTON (−0.3±1.8)%, and MR-ACRESOLUTE (0.3±1.7)%, ordered by average bias. The overall best performing methods (MR-ACBOSTON, MR-ACMAXPROB, MR-ACRESOLUTE and MR-ACUCL, ordered alphabetically) showed regional average errors within ±3% of PET with CT-AC in all regions of the brain with FDG, and the same four methods, as well as MR-ACCAR-RiDR, showed that for 95% of the patients, 95% of brain voxels had an uptake that deviated by less than 15% from the reference. Comparable performance was obtained with PiB and florbetapir. Conclusions: All of the proposed novel methods have an average global performance within likely acceptable limits (±5% of CT-based reference), and the main difference among the methods was found in the robustness, outlier analysis, and clinical feasibility. Overall, the best performing methods were MR-ACBOSTON, MR-ACMAXPROB, MR-ACRESOLUTE and MR-ACUCL, ordered alphabetically. These methods all minimized the number of outliers, standard deviation, and average global and local error. The methods MR-ACMUNICH and MR-ACCAR-RiDR were both within acceptable quantitative limits, so these methods should be considered if processing time is a factor. The method MR-ACSEGBONE also demonstrates promising results, and performs well within the likely acceptable quantitative limits. For clinical routine scans where processing time can be a key factor, this vendor-provided solution currently outperforms most methods. With the performance of the methods presented here, it may be concluded that the challenge of improving the accuracy of MR-AC in adult brains with normal anatomy has been solved to a quantitatively acceptable degree, which is smaller than the quantification reproducibility in PET imaging.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Article . 2016
    Data sources: PubMed Central
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    NeuroImage
    Other literature type . Article . 2017
    License: CC BY NC ND
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    UNC Dataverse
    Article . 2017
    Data sources: Datacite
    Hal-Diderot
    Article . 2017
    Data sources: Hal-Diderot
    Hal-Diderot
    Conference object . 2016
    Data sources: Hal-Diderot
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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      Europe PubMed Central
      Article . 2016
      Data sources: PubMed Central
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      NeuroImage
      Other literature type . Article . 2017
      License: CC BY NC ND
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      UNC Dataverse
      Article . 2017
      Data sources: Datacite
      Hal-Diderot
      Article . 2017
      Data sources: Hal-Diderot
      Hal-Diderot
      Conference object . 2016
      Data sources: Hal-Diderot
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Qiang Luo; Qiang Chen; Wenjia Wang; Sylvane Desrivières; +40 Authors

    Importance: Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective: To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations. Design, Setting, and Participants: Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. This was a population-based, multicenter study combined with a clinical sample that included participants from the IMAGEN cohort, Saguenay Youth Study, Three-City Study, and Lieber Institute for Brain Development sample cohorts and UK biobank who were assessed for both brain imaging and genetic sequencing. Clinical samples included patients with schizophrenia and unaffected siblings of patients from the Lieber Institute for Brain Development study. Data were analyzed between October 2015 and April 2018. Main Outcomes and Measures: Gray matter volume was assessed by neuroimaging and genetic variants were genotyped by Illumina BeadChip. Results: The discovery sample included 1721 adolescents (873 girls [50.7%]), with a mean (SD) age of 14.44 (0.41) years. The replication samples consisted of 8690 healthy adults (4497 women [51.8%]) from 4 independent studies across the life span. A nonsynonymous genetic variant (minor T allele of rs13107325 in SLC39A8, a gene implicated in schizophrenia) was associated with greater gray matter volume of the putamen (variance explained of 4.21% in the left hemisphere; 8.66; 95% CI, 6.59-10.81; P = 5.35 × 10-18; and 4.44% in the right hemisphere; t = 8.90; 95% CI, 6.75-11.19; P = 6.80 × 10-19) and also with a lower gene expression of SLC39A8 specifically in the putamen (t127 = -3.87; P = 1.70 × 10-4). The identified association was validated in samples across the life span but was significantly weakened in both patients with schizophrenia (z = -3.05; P =.002; n = 157) and unaffected siblings (z = -2.08; P =.04; n = 149). Conclusions and Relevance: Our results show that a missense mutation in gene SLC39A8 is associated with larger gray matter volume in the putamen and that this association is significantly weakened in schizophrenia. These results may suggest a role for aberrant ion transport in the etiology of psychosis and provide a target for preemptive developmental interventions aimed at restoring the functional effect of this mutation..

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    JAMA Psychiatry
    Article
    License: CC BY
    Data sources: UnpayWall
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Serveur académique lausannois
    Article . 2019
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Hal-Diderot
    Article . 2019
    Data sources: Hal-Diderot
    JAMA Psychiatry
    Article . 2019
    Data sources: Crossref
    HAL-Inserm
    Article . 2019
    Data sources: HAL-Inserm
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      JAMA Psychiatry
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      Data sources: UnpayWall
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      Serveur académique lausannois
      Article . 2019
      License: CC BY
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Hal-Diderot
      Article . 2019
      Data sources: Hal-Diderot
      JAMA Psychiatry
      Article . 2019
      Data sources: Crossref
      HAL-Inserm
      Article . 2019
      Data sources: HAL-Inserm
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Van Bavel, Jay J.; Cichocka, Aleksandra; Capraro, Valerio; Sjåstad, Hallgeir; +26 Authors

    Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.

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    Scholarship@Western
    Other literature type . 2022
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      Scholarship@Western
      Other literature type . 2022
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    Authors: Lau, Nathan; Wilkey, Eric; Soltanlou, Mojtaba; Lagacé-Cusiac, Rebekka; +13 Authors

    During the COVID-19 pandemic, people across the globe have been exposed to large amounts of statistical data. Previous studies have shown that individuals’ mathematical understanding of health-related information affects their attitudes and behaviours. Here, we investigate the relation between (i) basic numeracy, (ii) COVID-19 health numeracy, and (iii) COVID-19 health-related attitudes and behaviours. An online survey measuring these three variables was distributed in Canada, the United States (US) and the United Kingdom (UK) (n = 2032). In line with predictions, basic numeracy was positively related to COVID-19 health numeracy. However, predictions, neither basic numeracy nor COVID-19 health numeracy was related to COVID-19 healthrelated attitudes and behaviours (e.g. follow experts’ recommendations on social distancing, wearing masks etc.). Multi-group analysis was used to investigate mean differences and differences in the strength of the correlation across countries. Results indicate there were no between-country differences in the correlations between the main constructs but there were between-country differences in latent means. Overall, results suggest that while basic numeracy is related to one’s understanding of data about COVID-19, better numeracy alone is not enough to influence a population’s health-related attitudes about disease severity and to increase the likelihood of following public health advice. ispartof: Royal Society Open Science vol:9 issue:3 pages:201303-201303 ispartof: location:England status: published

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    Royal Society Open Science
    Article . 2022
    License: Royal Society Data Sharing and Accessibility
    Data sources: Crossref
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    Lirias
    Article . 2022
    Data sources: Lirias
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    DOAJ
    Article . 2022
    Data sources: DOAJ
    Open Science Framework
    Other literature type . 2022
    Data sources: Datacite
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    Authors: Benussi, Alberto; Alberici, Antonella; Jiskoot, Lize C; Olives, Jaume; +153 Authors

    Copyright © 2021 The Authors. The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages. EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Society, UK. Grant Number: AS-JF-19a-004-517; UK Dementia Research Institute; MRC Clinician Scientist Fellowship. Grant Number: MR/M008525/1; NIHR Rare Disease Translational Research Collaboration. Grant Number: BRC149/NS/MH.

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    Scholarship@Western
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    Alzheimer s & Dementia
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    Alzheimer s & Dementia
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    Authors: Bago, Bence; Kovacs, Marton; Protzko, John; Nagy, Tamas; +250 Authors

    M.A. Vadillo was supported by 2016-T1/SOC-1395 and 2020-5A/SOC-19723 from Comunidad de Madrid, PSI2017-85159-P from AEI and UE/FEDER. M.P.-C. was supported by 2017/01/X/HS6/01332 from the National Science Centre, Poland. P.M. was supported by Aarhus University Research Foundation (AUFF), starting grant: AUFF-E-2019-9-4. B. Bago was supported by ANR grant ANR-17-EURE-0010 (Investissements d'Avenir programme) and ANR Labex IAST. R.M.R. was supported by the Australian Research Council (DP180102384). N.B.D. was supported by CAPES grant no. 88887.364180/2019-00. C.S., K.A.. and I. Zettler were supported by the Carlsberg Foundation (CF16-0444) and the Independent Research Fund Denmark (7024-00057B). J.L. was supported by EXC 2126/1-390838866 under Germany's Excellence Strategy. K.B. was supported by the following grants from the National Science Centre, Poland: (1) while working on the data collection, no. 2015/19/D/HS6/00641, (2) while working on the final version of the paper, no. 2019/35/B/HS6/00528. A.W. was supported by FONDECYT 11190980, CONICYT. A. Fleischmann was supported by the German Research Foundation (research unit grant FOR-2150, LA 3566/1-2). H.Y. was supported by JSPS grant 18K03010. Y.Y. was supported by JSPS KAKENHI (16H03079, 17H00875, 18K12015 and 20H04581). K.Q. was supported by JSPS KAKENHI (17H06342, 20K03479 and 20KK0054). A. Ikeda was supported by JSPS KAKENHI (20J21976). K.M.K. was supported by National Natural Science Foundation of China (NSFC) grant no. 31530032 and Key Technological Projects of Guangdong Province grant no. 2018B030335001. J.B.C. was supported by National Science Foundation Graduate Research Fellowship grant no. DGE-1839285. M. Parzuchowski, K. Rybus and N.M.S. were supported by Polish National Science Center and DFG Beethoven grant 2016/23/G/HS6/01775. A.C.S. was supported by Portuguese National Foundation for Science and Technology grant no. SFRH/BD/126304/2016. L. Boncinelli was supported by PRIN 2017 grant no. 20178293XT (Italian Ministry of Education and Research). M.F.F.R. was supported by PSA 006 BRA 008 Data Collection in Support of PSADM 001 Measurement Invariance Project. M. Misiak was supported by a scholarship from the Foundation for Polish Science (START) and by a scholarship from the National Science Centre (2020/36/T/HS6/00256). P.B. was supported by Slovak Research and Development Agency project no. APVV-18-0140. M.A. was supported by Slovak Research and Development Agency project no. APVV-17-0418 and project PRIMUS/20/HUM/009. A. Findor and M.H. were supported by the Slovak Research and Development Agency under contract no. APVV-17-0596. T.G. was supported by the Social Sciences and Humanities Research Council of Canada (no. 950-224884). P.P. was supported by the Swedish Research Council (2016-06793). Y.L. was supported by The Project of Philosophy and Social Science Research in Colleges and Universities in Jiangsu Province (grant no. 2020SJA0017). M. Kowal was supported by a scholarship from the National Science Centre (2019/33/N/HS6/00054). P.A. was supported by UID/PSI/03125/2019 from the Portuguese National Foundation for Science and Technology. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The study of moral judgements often centres on moral dilemmas in which options consistent with deontological perspectives (that is, emphasizing rules, individual rights and duties) are in conflict with options consistent with utilitarian judgements (that is, following the greater good based on consequences). Greene et al. (2009) showed that psychological and situational factors (for example, the intent of the agent or the presence of physical contact between the agent and the victim) can play an important role in moral dilemma judgements (for example, the trolley problem). Our knowledge is limited concerning both the universality of these effects outside the United States and the impact of culture on the situational and psychological factors affecting moral judgements. Thus, we empirically tested the universality of the effects of intent and personal force on moral dilemma judgements by replicating the experiments of Greene et al. in 45 countries from all inhabited continents. We found that personal force and its interaction with intention exert influence on moral judgements in the US and Western cultural clusters, replicating and expanding the original findings. Moreover, the personal force effect was present in all cultural clusters, suggesting it is culturally universal. The evidence for the cultural universality of the interaction effect was inconclusive in the Eastern and Southern cultural clusters (depending on exclusion criteria). We found no strong association between collectivism/individualism and moral dilemma judgements. Including participants from 45 countries, Bago et al. find that the situational factors that affect moral reasoning are shared across countries, with diminished observed cultural variation. Comunidad de Madrid [2016-T1/SOC-1395, 2020-5A/SOC-19723]; AEI [PSI2017-85159-P]; UE/FEDER; National Science Centre, Poland [2017/01/X/HS6/01332, 2015/19/D/HS6/00641, 2019/35/B/HS6/00528]; Aarhus University Research Foundation (AUFF) [AUFF-E-2019-9-4]; ANR [ANR-17-EURE-0010]; ANR Labex IAST; Australian Research Council [DP180102384]; CAPES [88887.364180/2019-00]; Carlsberg Foundation [CF16-0444]; Independent Research Fund Denmark [7024-00057B]; Germany's Excellence Strategy [EXC 2126/1-390838866]; FONDECYT, CONICYT [11190980]; German Research Foundation [FOR-2150, LA 3566/1-2]; JSPS [18K03010]; JSPS KAKENHI [16H03079, 17H00875, 18K12015, 20H04581, 17H06342, 20K03479, 20KK0054, 20J21976]; Natural Science Foundation of China (NSFC) [31530032]; Key Technological Projects of Guangdong Province [2018B030335001]; National Science Foundation Graduate Research Fellowship [DGE-1839285]; Polish National Science Center; DFG Beethoven [2016/23/G/HS6/01775]; Portuguese National Foundation for Science and Technology [SFRH/BD/126304/2016, UID/PSI/03125/2019]; PRIN 2017 (Italian Ministry of Education and Research) [20178293XT]; PSA 006 BRA 008 Data Collection in Support of PSADM 001 Measurement Invariance Project; Foundation for Polish Science (START); National Science Centre [2020/36/T/HS6/00256, 2019/33/N/HS6/00054]; Slovak Research and Development Agency [APVV-18-0140, APVV-17-0418, PRIMUS/20/HUM/009, APVV-17-0596]; Social Sciences and Humanities Research Council of Canada [950-224884]; Swedish Research Council [2016-06793]; Project of Philosophy and Social Science Research in Colleges and Universities in Jiangsu Province [2020SJA0017]

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    Nature Human Behaviour
    Article . 2022
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    NARCIS
    Article . 2022
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    ACU Research Bank
    Article . 2022
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    Nature Human Behaviour
    Article . 2022
    Data sources: WU Research
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Michael P. Milham; Lei Ai; Bonhwang Koo; Ting Xu; +66 Authors

    Summary Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets. The PRIMatE Data Exchange (PRIME-DE) consortium is an open science resource for the neuroimaging community aiming to facilitate efforts to map the non-human primate connectome. It aggregates and shares anatomical, functional, and diffusion MRI datasets from laboratories throughout the world. Highlights • Openly shared, large non-human primate neuroimaging data resource • Multiple imaging modalities contributed from investigators around the world • Quality assessments of the dataset • Discussed pitfalls and challenges in analyzing the non-human primate MRI data

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Article . 2018
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    Caltech Authors
    Article . 2018
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    NARCIS
    Article . 2018
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    Article . 2018
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    Apollo
    Article . 2019
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    Data sources: Datacite
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    NARCIS
    Article . 2018
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    Neuron
    Article . 2018
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    MPG.PuRe
    Article . 2018
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    Neuron
    Article . 2018
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    Apollo
    Other literature type . 2018
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    MPG.PuRe
    Article . 2018
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    Oxford University Research Archive
    Other literature type . 2018
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    NARCIS
    Article . 2018
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    Radboud Repository
    Article . 2018
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    Neuron
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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      Europe PubMed Central
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      Caltech Authors
      Article . 2018
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      Article . 2018
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      Article . 2018
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      Apollo
      Article . 2019
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      Article . 2018
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      Neuron
      Article . 2018
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      Article . 2018
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      Neuron
      Article . 2018
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      Other literature type . 2018
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      MPG.PuRe
      Article . 2018
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      Oxford University Research Archive
      Other literature type . 2018
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      Article . 2018
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      Article . 2018
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      Neuron
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Claes Nøhr Ladefoged; Ian Law; Udunna C. Anazodo; Keith St. Lawrence; +24 Authors

    Aim: To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the current vendor-implemented MR-AC methods for absolute quantification, a number of prototype methods have been proposed in the literature. These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based. These proposed methods in general demonstrated improvements compared to vendor-implemented AC, and many studies report deviations in PET uptake after AC of only a few percent from a gold standard CT-AC. Using a unified quantitative evaluation with identical metrics, subject cohort, and common CT-based reference, the aims of this study were to evaluate a selection of novel methods proposed in the literature, and identify the ones suitable for clinical use. Methods: In total, 11 AC methods were evaluated: two vendor-implemented (MR-ACDIXON and MR-ACUTE), five based on template/atlas information (MR-ACSEGBONE (Koesters et al., 2016), MR-ACONTARIO (Anazodo et al., 2014), MR-ACBOSTON (Izquierdo-Garcia et al., 2014), MR-ACUCL (Burgos et al., 2014), and MR-ACMAXPROB (Merida et al., 2015)), one based on simultaneous reconstruction of attenuation and emission (MR-ACMLAA (Benoit et al., 2015)), and three based on image-segmentation (MR-ACMUNICH (Cabello et al., 2015), MR-ACCAR-RiDR (Juttukonda et al., 2015), and MR-ACRESOLUTE (Ladefoged et al., 2015)). We selected 359 subjects who were scanned using one of the following radiotracers: [18F]FDG (210), [11C]PiB (51), and [18F]florbetapir (98). The comparison to AC with a gold standard CT was performed both globally and regionally, with a special focus on robustness and outlier analysis. Results: The average performance in PET tracer uptake was within ±5% of CT for all of the proposed methods, with the average±SD global percentage bias in PET FDG uptake for each method being: MR-ACDIXON (−11.3±3.5)%, MR-ACUTE (−5.7±2.0)%, MR-ACONTARIO (−4.3±3.6)%, MR-ACMUNICH (3.7±2.1)%, MR-ACMLAA (−1.9±2.6)%, MR-ACSEGBONE (−1.7±3.6)%, MR-ACUCL (0.8±1.2)%, MR-ACCAR-RiDR (−0.4±1.9)%, MR-ACMAXPROB (−0.4±1.6)%, MR-ACBOSTON (−0.3±1.8)%, and MR-ACRESOLUTE (0.3±1.7)%, ordered by average bias. The overall best performing methods (MR-ACBOSTON, MR-ACMAXPROB, MR-ACRESOLUTE and MR-ACUCL, ordered alphabetically) showed regional average errors within ±3% of PET with CT-AC in all regions of the brain with FDG, and the same four methods, as well as MR-ACCAR-RiDR, showed that for 95% of the patients, 95% of brain voxels had an uptake that deviated by less than 15% from the reference. Comparable performance was obtained with PiB and florbetapir. Conclusions: All of the proposed novel methods have an average global performance within likely acceptable limits (±5% of CT-based reference), and the main difference among the methods was found in the robustness, outlier analysis, and clinical feasibility. Overall, the best performing methods were MR-ACBOSTON, MR-ACMAXPROB, MR-ACRESOLUTE and MR-ACUCL, ordered alphabetically. These methods all minimized the number of outliers, standard deviation, and average global and local error. The methods MR-ACMUNICH and MR-ACCAR-RiDR were both within acceptable quantitative limits, so these methods should be considered if processing time is a factor. The method MR-ACSEGBONE also demonstrates promising results, and performs well within the likely acceptable quantitative limits. For clinical routine scans where processing time can be a key factor, this vendor-provided solution currently outperforms most methods. With the performance of the methods presented here, it may be concluded that the challenge of improving the accuracy of MR-AC in adult brains with normal anatomy has been solved to a quantitatively acceptable degree, which is smaller than the quantification reproducibility in PET imaging.

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    Europe PubMed Central
    Article . 2016
    Data sources: PubMed Central
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    NeuroImage
    Other literature type . Article . 2017
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    Article . 2017
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    Article . 2017
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      Europe PubMed Central
      Article . 2016
      Data sources: PubMed Central
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      NeuroImage
      Other literature type . Article . 2017
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      UNC Dataverse
      Article . 2017
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      Article . 2017
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    Authors: Qiang Luo; Qiang Chen; Wenjia Wang; Sylvane Desrivières; +40 Authors

    Importance: Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective: To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations. Design, Setting, and Participants: Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. This was a population-based, multicenter study combined with a clinical sample that included participants from the IMAGEN cohort, Saguenay Youth Study, Three-City Study, and Lieber Institute for Brain Development sample cohorts and UK biobank who were assessed for both brain imaging and genetic sequencing. Clinical samples included patients with schizophrenia and unaffected siblings of patients from the Lieber Institute for Brain Development study. Data were analyzed between October 2015 and April 2018. Main Outcomes and Measures: Gray matter volume was assessed by neuroimaging and genetic variants were genotyped by Illumina BeadChip. Results: The discovery sample included 1721 adolescents (873 girls [50.7%]), with a mean (SD) age of 14.44 (0.41) years. The replication samples consisted of 8690 healthy adults (4497 women [51.8%]) from 4 independent studies across the life span. A nonsynonymous genetic variant (minor T allele of rs13107325 in SLC39A8, a gene implicated in schizophrenia) was associated with greater gray matter volume of the putamen (variance explained of 4.21% in the left hemisphere; 8.66; 95% CI, 6.59-10.81; P = 5.35 × 10-18; and 4.44% in the right hemisphere; t = 8.90; 95% CI, 6.75-11.19; P = 6.80 × 10-19) and also with a lower gene expression of SLC39A8 specifically in the putamen (t127 = -3.87; P = 1.70 × 10-4). The identified association was validated in samples across the life span but was significantly weakened in both patients with schizophrenia (z = -3.05; P =.002; n = 157) and unaffected siblings (z = -2.08; P =.04; n = 149). Conclusions and Relevance: Our results show that a missense mutation in gene SLC39A8 is associated with larger gray matter volume in the putamen and that this association is significantly weakened in schizophrenia. These results may suggest a role for aberrant ion transport in the etiology of psychosis and provide a target for preemptive developmental interventions aimed at restoring the functional effect of this mutation..

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    JAMA Psychiatry
    Article
    License: CC BY
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    Serveur académique lausannois
    Article . 2019
    License: CC BY
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    Hal-Diderot
    Article . 2019
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    JAMA Psychiatry
    Article . 2019
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    HAL-Inserm
    Article . 2019
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      JAMA Psychiatry
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      Serveur académique lausannois
      Article . 2019
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      Hal-Diderot
      Article . 2019
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      JAMA Psychiatry
      Article . 2019
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      Article . 2019
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    Authors: Van Bavel, Jay J.; Cichocka, Aleksandra; Capraro, Valerio; Sjåstad, Hallgeir; +26 Authors

    Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.

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    Authors: Lau, Nathan; Wilkey, Eric; Soltanlou, Mojtaba; Lagacé-Cusiac, Rebekka; +13 Authors

    During the COVID-19 pandemic, people across the globe have been exposed to large amounts of statistical data. Previous studies have shown that individuals’ mathematical understanding of health-related information affects their attitudes and behaviours. Here, we investigate the relation between (i) basic numeracy, (ii) COVID-19 health numeracy, and (iii) COVID-19 health-related attitudes and behaviours. An online survey measuring these three variables was distributed in Canada, the United States (US) and the United Kingdom (UK) (n = 2032). In line with predictions, basic numeracy was positively related to COVID-19 health numeracy. However, predictions, neither basic numeracy nor COVID-19 health numeracy was related to COVID-19 healthrelated attitudes and behaviours (e.g. follow experts’ recommendations on social distancing, wearing masks etc.). Multi-group analysis was used to investigate mean differences and differences in the strength of the correlation across countries. Results indicate there were no between-country differences in the correlations between the main constructs but there were between-country differences in latent means. Overall, results suggest that while basic numeracy is related to one’s understanding of data about COVID-19, better numeracy alone is not enough to influence a population’s health-related attitudes about disease severity and to increase the likelihood of following public health advice. ispartof: Royal Society Open Science vol:9 issue:3 pages:201303-201303 ispartof: location:England status: published

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    Royal Society Open Science
    Article . 2022
    License: Royal Society Data Sharing and Accessibility
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    Lirias
    Article . 2022
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    DOAJ
    Article . 2022
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    Open Science Framework
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    Authors: Benussi, Alberto; Alberici, Antonella; Jiskoot, Lize C; Olives, Jaume; +153 Authors

    Copyright © 2021 The Authors. The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages. EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Society, UK. Grant Number: AS-JF-19a-004-517; UK Dementia Research Institute; MRC Clinician Scientist Fellowship. Grant Number: MR/M008525/1; NIHR Rare Disease Translational Research Collaboration. Grant Number: BRC149/NS/MH.

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    Scholarship@Western
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    Alzheimer s & Dementia
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    Alzheimer s & Dementia
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    Authors: Bago, Bence; Kovacs, Marton; Protzko, John; Nagy, Tamas; +250 Authors

    M.A. Vadillo was supported by 2016-T1/SOC-1395 and 2020-5A/SOC-19723 from Comunidad de Madrid, PSI2017-85159-P from AEI and UE/FEDER. M.P.-C. was supported by 2017/01/X/HS6/01332 from the National Science Centre, Poland. P.M. was supported by Aarhus University Research Foundation (AUFF), starting grant: AUFF-E-2019-9-4. B. Bago was supported by ANR grant ANR-17-EURE-0010 (Investissements d'Avenir programme) and ANR Labex IAST. R.M.R. was supported by the Australian Research Council (DP180102384). N.B.D. was supported by CAPES grant no. 88887.364180/2019-00. C.S., K.A.. and I. Zettler were supported by the Carlsberg Foundation (CF16-0444) and the Independent Research Fund Denmark (7024-00057B). J.L. was supported by EXC 2126/1-390838866 under Germany's Excellence Strategy. K.B. was supported by the following grants from the National Science Centre, Poland: (1) while working on the data collection, no. 2015/19/D/HS6/00641, (2) while working on the final version of the paper, no. 2019/35/B/HS6/00528. A.W. was supported by FONDECYT 11190980, CONICYT. A. Fleischmann was supported by the German Research Foundation (research unit grant FOR-2150, LA 3566/1-2). H.Y. was supported by JSPS grant 18K03010. Y.Y. was supported by JSPS KAKENHI (16H03079, 17H00875, 18K12015 and 20H04581). K.Q. was supported by JSPS KAKENHI (17H06342, 20K03479 and 20KK0054). A. Ikeda was supported by JSPS KAKENHI (20J21976). K.M.K. was supported by National Natural Science Foundation of China (NSFC) grant no. 31530032 and Key Technological Projects of Guangdong Province grant no. 2018B030335001. J.B.C. was supported by National Science Foundation Graduate Research Fellowship grant no. DGE-1839285. M. Parzuchowski, K. Rybus and N.M.S. were supported by Polish National Science Center and DFG Beethoven grant 2016/23/G/HS6/01775. A.C.S. was supported by Portuguese National Foundation for Science and Technology grant no. SFRH/BD/126304/2016. L. Boncinelli was supported by PRIN 2017 grant no. 20178293XT (Italian Ministry of Education and Research). M.F.F.R. was supported by PSA 006 BRA 008 Data Collection in Support of PSADM 001 Measurement Invariance Project. M. Misiak was supported by a scholarship from the Foundation for Polish Science (START) and by a scholarship from the National Science Centre (2020/36/T/HS6/00256). P.B. was supported by Slovak Research and Development Agency project no. APVV-18-0140. M.A. was supported by Slovak Research and Development Agency project no. APVV-17-0418 and project PRIMUS/20/HUM/009. A. Findor and M.H. were supported by the Slovak Research and Development Agency under contract no. APVV-17-0596. T.G. was supported by the Social Sciences and Humanities Research Council of Canada (no. 950-224884). P.P. was supported by the Swedish Research Council (2016-06793). Y.L. was supported by The Project of Philosophy and Social Science Research in Colleges and Universities in Jiangsu Province (grant no. 2020SJA0017). M. Kowal was supported by a scholarship from the National Science Centre (2019/33/N/HS6/00054). P.A. was supported by UID/PSI/03125/2019 from the Portuguese National Foundation for Science and Technology. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The study of moral judgements often centres on moral dilemmas in which options consistent with deontological perspectives (that is, emphasizing rules, individual rights and duties) are in conflict with options consistent with utilitarian judgements (that is, following the greater good based on consequences). Greene et al. (2009) showed that psychological and situational factors (for example, the intent of the agent or the presence of physical contact between the agent and the victim) can play an important role in moral dilemma judgements (for example, the trolley problem). Our knowledge is limited concerning both the universality of these effects outside the United States and the impact of culture on the situational and psychological factors affecting moral judgements. Thus, we empirically tested the universality of the effects of intent and personal force on moral dilemma judgements by replicating the experiments of Greene et al. in 45 countries from all inhabited continents. We found that personal force and its interaction with intention exert influence on moral judgements in the US and Western cultural clusters, replicating and expanding the original findings. Moreover, the personal force effect was present in all cultural clusters, suggesting it is culturally universal. The evidence for the cultural universality of the interaction effect was inconclusive in the Eastern and Southern cultural clusters (depending on exclusion criteria). We found no strong association between collectivism/individualism and moral dilemma judgements. Including participants from 45 countries, Bago et al. find that the situational factors that affect moral reasoning are shared across countries, with diminished observed cultural variation. Comunidad de Madrid [2016-T1/SOC-1395, 2020-5A/SOC-19723]; AEI [PSI2017-85159-P]; UE/FEDER; National Science Centre, Poland [2017/01/X/HS6/01332, 2015/19/D/HS6/00641, 2019/35/B/HS6/00528]; Aarhus University Research Foundation (AUFF) [AUFF-E-2019-9-4]; ANR [ANR-17-EURE-0010]; ANR Labex IAST; Australian Research Council [DP180102384]; CAPES [88887.364180/2019-00]; Carlsberg Foundation [CF16-0444]; Independent Research Fund Denmark [7024-00057B]; Germany's Excellence Strategy [EXC 2126/1-390838866]; FONDECYT, CONICYT [11190980]; German Research Foundation [FOR-2150, LA 3566/1-2]; JSPS [18K03010]; JSPS KAKENHI [16H03079, 17H00875, 18K12015, 20H04581, 17H06342, 20K03479, 20KK0054, 20J21976]; Natural Science Foundation of China (NSFC) [31530032]; Key Technological Projects of Guangdong Province [2018B030335001]; National Science Foundation Graduate Research Fellowship [DGE-1839285]; Polish National Science Center; DFG Beethoven [2016/23/G/HS6/01775]; Portuguese National Foundation for Science and Technology [SFRH/BD/126304/2016, UID/PSI/03125/2019]; PRIN 2017 (Italian Ministry of Education and Research) [20178293XT]; PSA 006 BRA 008 Data Collection in Support of PSADM 001 Measurement Invariance Project; Foundation for Polish Science (START); National Science Centre [2020/36/T/HS6/00256, 2019/33/N/HS6/00054]; Slovak Research and Development Agency [APVV-18-0140, APVV-17-0418, PRIMUS/20/HUM/009, APVV-17-0596]; Social Sciences and Humanities Research Council of Canada [950-224884]; Swedish Research Council [2016-06793]; Project of Philosophy and Social Science Research in Colleges and Universities in Jiangsu Province [2020SJA0017]

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    Nature Human Behaviour
    Article . 2022
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    NARCIS
    Article . 2022
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    ACU Research Bank
    Article . 2022
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    Nature Human Behaviour
    Article . 2022
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Michael P. Milham; Lei Ai; Bonhwang Koo; Ting Xu; +66 Authors

    Summary Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets. The PRIMatE Data Exchange (PRIME-DE) consortium is an open science resource for the neuroimaging community aiming to facilitate efforts to map the non-human primate connectome. It aggregates and shares anatomical, functional, and diffusion MRI datasets from laboratories throughout the world. Highlights • Openly shared, large non-human primate neuroimaging data resource • Multiple imaging modalities contributed from investigators around the world • Quality assessments of the dataset • Discussed pitfalls and challenges in analyzing the non-human primate MRI data

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    Apollo
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    Neuron
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