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description Publicationkeyboard_double_arrow_right Article 2016 Canada EnglishNature Publishing Group NIH | Administrative Core, UKRI | MRC Centre for Reproducti..., NIH | Characterization of the m... +4 projectsNIH| Administrative Core ,UKRI| MRC Centre for Reproductive Health ,NIH| Characterization of the macrophage-derived regenerative signals in intestine ,WT| The Metastatic Cascade: Macrophages Lead the Way. ,NIH| Differentiating Radio-sensitivities Among Intestinal Stem Cell Pools ,NIH| Paul Calabresi Career Development Award for Clinical Oncology (K12) ,NHMRC| The influence of a-actinin-3 on muscle structure, metabolism, performance and response to diet and diseaseSubhrajit Saha; Evelyn Aranda; Yoku Hayakawa; Payel Bhanja; Safinur Atay; N Patrik Brodin; Jiufeng Li; Samuel Asfaha; Laibin Liu; Yagnesh Tailor; Jinghang Zhang; Andrew K. Godwin; Wolfgang A. Tome; Timothy C. Wang; Chandan Guha; Jeffrey W. Pollard;pmc: PMC5065628
pmid: 27734833
WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and role in intestinal stem cell (ISC) and epithelial repair remains unknown. Macrophages are a major constituent of the intestinal stroma. Here, we analyse the role of macrophage-derived WNT in intestinal repair in mice by inhibiting their release using a macrophage-restricted ablation of Porcupine, a gene essential for WNT synthesis. Such Porcn-depleted mice have normal intestinal morphology but are hypersensitive to radiation injury in the intestine compared with wild-type (WT) littermates. Porcn-null mice are rescued from radiation lethality by treatment with WT but not Porcn-null bone marrow macrophage-conditioned medium (CM). Depletion of extracellular vesicles (EV) from the macrophage CM removes WNT function and its ability to rescue ISCs from radiation lethality. Therefore macrophage-derived EV-packaged WNTs are essential for regenerative response of intestine against radiation. The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intestinal repair.
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For further information contact us at helpdesk@openaire.eu137 citations 137 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, Canada, Italy, Denmark, FranceOvid Technologies (Wolters Kluwer Health) NIH | Institutional Clinical an..., NIH | Channelopathy-Associated ..., NIH | The Intellectual and Deve... +2 projectsNIH| Institutional Clinical and Translational Science Award ,NIH| Channelopathy-Associated Epilepsy Research Center ,NIH| The Intellectual and Developmental Disabilities Research Center at CHOP/Penn ,NIH| Joint analysis of genomic and electronic medical record data to assess outcomes and drug response in pediatric epilepsies ,NHMRC| Melanoma diagnosis, and the effect of screening on depth of invasion of melanoma.Johannesen K. M.; Gardella E.; Gjerulfsen C. E.; Bayat A.; Rouhl R. P. W.; Reijnders M.; Whalen S.; Keren B.; Buratti J.; Courtin T.; Wierenga K. J.; Isidor B.; Piton A.; Faivre L.; Garde A.; Moutton S.; Tran-Mau-Them F.; Denomme-Pichon A. -S.; Coubes C.; Larson A.; Esser M. J.; Appendino J. P.; Al-Hertani W.; Gamboni B.; Mampel A.; Mayorga L.; Orsini A.; Bonuccelli A.; Suppiej A.; Van-Gils J.; Vogt J.; Damioli S.; Giordano L.; Moortgat S.; Wirrell E.; Hicks S.; Kini U.; Noble N.; Stewart H.; Asakar S.; Cohen J. S.; Naidu S. R.; Collier A.; Brilstra E. H.; Li M. H.; Brew C.; Bigoni S.; Ognibene D.; Ballardini E.; Ruivenkamp C.; Faggioli R.; Afenjar A.; Rodriguez D.; Bick D.; Segal D.; Coman D.; Gunning B.; Devinsky O.; Demmer L. A.; Grebe T.; Pruna D.; Cursio I.; Greenhalgh L.; Graziano C.; Singh R. R.; Cantalupo G.; Willems M.; Yoganathan S.; Goes F.; Leventer R. J.; Colavito D.; Olivotto S.; Scelsa B.; Andrade A. V.; Ratke K.; Tokarz F.; Khan A. S.; Ormieres C.; Benko W.; Keough K.; Keros S.; Hussain S.; Franques A.; Varsalone F.; Gronborg S.; Mignot C.; Heron D.; Nava C.; Isapof A.; Borlot F.; Whitney R.; Ronan A.; Foulds N.; Somorai M.; Brandsema J.; Helbig K. L.; Helbig I.; Ortiz-Gonzalez X. R.; Dubbs H.; Vitobello A.; Anderson M.; Spadafore D.; Hunt D.; Moller R. S.; Rubboli G.;handle: 11562/1063816 , 11392/2475339
International audience; Background and Objectives Purine-rich element-binding protein A ( PURA ) gene encodes Pur-α, a conserved protein essential for normal postnatal brain development. Recently, a PURA syndrome characterized by intellectual disability, hypotonia, epilepsy, and dysmorphic features was suggested. The aim of this study was to define and expand the phenotypic spectrum of PURA syndrome by collecting data, including EEG, from a large cohort of affected patients. Methods Data on unpublished and published cases were collected through the PURA Syndrome Foundation and the literature. Data on clinical, genetic, neuroimaging, and neurophysiologic features were obtained. Results A cohort of 142 patients was included. Characteristics of the PURA syndrome included neonatal hypotonia, feeding difficulties, and respiratory distress. Sixty percent of the patients developed epilepsy with myoclonic, generalized tonic-clonic, focal seizures, and/or epileptic spasms. EEG showed generalized, multifocal, or focal epileptic abnormalities. Lennox-Gastaut was the most common epilepsy syndrome. Drug refractoriness was common: 33.3% achieved seizure freedom. We found 97 pathogenic variants in PURA without any clear genotype-phenotype associations. Discussion The PURA syndrome presents with a developmental and epileptic encephalopathy with characteristics recognizable from neonatal age, which should prompt genetic screening. Sixty percent have drug-resistant epilepsy with focal or generalized seizures. We collected more than 90 pathogenic variants without observing overt genotype-phenotype associations.
Archivio istituziona... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaUniversity of Southern Denmark Research OutputArticle . 2021Data sources: University of Southern Denmark Research OutputIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Archivio istituziona... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaUniversity of Southern Denmark Research OutputArticle . 2021Data sources: University of Southern Denmark Research OutputIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1212/nxg.0000000000000613&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Turkey, Canada, ItalySAGE Publications NHMRC | Depressive and bipolar di...NHMRC| Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovationsGordon Parker; Gabriela Tavella; Glenda MacQueen; Michael Berk; Heinz Grunze; Thilo Deckersbach; David L. Dunner; Martha Sajatovic; Jay D. Amsterdam; Terence A. Ketter; Lakshmi N. Yatham; Lars Vedel Kessing; Darryl Bassett; Mark Zimmerman; Kostas N. Fountoulakis; Anne Duffy; Martin Alda; Cynthia V. Calkin; Verinder Sharma; Amit Anand; Manpreet K. Singh; Tomas Hajek; Philip Boyce; Benicio N. Frey; David J. Castle; Allan H. Young; Eduard Vieta; Janusz K. Rybakowski; Holly A. Swartz; Ayal Schaffer; Greg Murray; Adam Bayes; Raymond W. Lam; Emre Bora; Robert M. Post; Michael J. Ostacher; Beny Lafer; Anthony J. Cleare; Katherine E. Burdick; Claire O'Donovan; Abigail Ortiz; Chantal Henry; Shigenobu Kanba; Joshua D. Rosenblat; Sagar V. Parikh; David J. Bond; Michael F. Grunebaum; Sophia Frangou; Joseph F. Goldberg; Margo Orum; David N. Osser; Mark A. Frye; Roger S. McIntyre; Andrea Fagiolini; Vijaya Manicavasagar; Gabrielle A. Carlson; Gin S Malhi;handle: 11365/1067477
Objective: To derive new criteria sets for defining manic and hypomanic episodes (and thus for defining the bipolar I and II disorders), an international Task Force was assembled and termed AREDOC reflecting its role of Assessment, Revision and Evaluation of DSM and other Operational Criteria. This paper reports on the first phase of its deliberations and interim criteria recommendations. Method: The first stage of the process consisted of reviewing Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and recent International Classification of Diseases criteria, identifying their limitations and generating modified criteria sets for further in-depth consideration. Task Force members responded to recommendations for modifying criteria and from these the most problematic issues were identified. Results: Principal issues focussed on by Task Force members were how best to differentiate mania and hypomania, how to judge ‘impairment’ (both in and of itself and allowing that functioning may sometimes improve during hypomanic episodes) and concern that rejecting some criteria (e.g. an imposed duration period) might risk false-positive diagnoses of the bipolar disorders. Conclusion: This first-stage report summarises the clinical opinions of international experts in the diagnosis and management of the bipolar disorders, allowing readers to contemplate diagnostic parameters that may influence their clinical decisions. The findings meaningfully inform subsequent Task Force stages (involving a further commentary stage followed by an empirical study) that are expected to generate improved symptom criteria for diagnosing the bipolar I and II disorders with greater precision and to clarify whether they differ dimensionally or categorically.
Australian & New Zea... arrow_drop_down Dokuz Eylul University Research Information SystemArticle . 2018Data sources: Dokuz Eylul University Research Information SystemUsiena air - Università di Siena; Australian & New Zealand Journal of PsychiatryArticle . 2018License: SAGE TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Australian & New Zea... arrow_drop_down Dokuz Eylul University Research Information SystemArticle . 2018Data sources: Dokuz Eylul University Research Information SystemUsiena air - Università di Siena; Australian & New Zealand Journal of PsychiatryArticle . 2018License: SAGE TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0004867418808382&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Canada, United KingdomFrontiers Media SA UKRI | Developing a test battery..., WT | TREAT-HD: targeting neuro..., NHMRC | A convergent approach to ... +1 projectsUKRI| Developing a test battery for evaluating treatment effects on emotional, motivational and social function in neuropsychiatry ,WT| TREAT-HD: targeting neurodegeneration in Huntington's disease ,NHMRC| A convergent approach to define the behavioural and pathophysiological signatures of neuropsychiatric symptoms ,UKRI| Development and validation of a rodent touchscreen battery for assessing motivation and affective stateAuthors: Christopher J. Heath; Christopher J. Heath; Claire O'Callaghan; Claire O'Callaghan; +9 AuthorsChristopher J. Heath; Christopher J. Heath; Claire O'Callaghan; Claire O'Callaghan; Sarah L. Mason; Benjamin U. Phillips; Lisa M. Saksida; Lisa M. Saksida; Trevor W. Robbins; Roger A. Barker; Timothy J. Bussey; Timothy J. Bussey; Barbara J. Sahakian;Copyright © 2019 Heath, O'Callaghan, Mason, Phillips, Saksida, Robbins, Barker, Bussey and Sahakian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation of promising findings between preclinical disease models and patients. Apathy is a common symptom in Huntington's disease. Due to its established genetic basis and the availability of defined animal models, this disease offers a robust translational framework for linking motivated behavior with underlying neurobiology and an ideal context in which to evaluate a quantitative, translational apathy assessment method. In this study we therefore aimed to demonstrate the validity of using touchscreen-delivered progressive ratio tasks to mirror apathy assessment in Huntington's disease patients and a representative mouse model. To do this we evaluated Huntington's disease patients (n = 23) and age-matched healthy controls (n = 20), and male R6/1 mice (n = 23) and wildtype controls (n = 29) for apathy-like behavior using touchscreen-delivered progressive ratio tasks. The primary outcome measure of the assessment was breakpoint, defined as the highest number of touchscreen responses emitted before task engagement ceased. Patients and R6/1 mice were both found to exhibit significantly reduced breakpoints relative to their respective control groups, consistent with apathy-like behavior. This performance was also not associated with motoric differences in either species. These data demonstrate the utility of touchscreen-delivered progressive ratio tasks in detecting clinically relevant motivational deficits in Huntington's disease. This approach may offer a platform from which clinically relevant mechanistic insights concerning motivation symptoms can be derived and provide an effective route for translation of promising preclinical findings into viable therapeutic interventions.
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For further information contact us at helpdesk@openaire.eu21 citations 21 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 18 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Canada, Netherlands, BelgiumWiley NIH | Laboratory of Neuro Imagi..., NIH | Social Withdrawal Followi..., NIH | Essential Features of Neu... +17 projectsNIH| Laboratory of Neuro Imaging Resource (LONIR) ,NIH| Social Withdrawal Following Trauma Exposure: a Neuroeconomic Approach ,NIH| Essential Features of Neural Damage in Mild Traumatic Brain Injury ,NIH| Research Training Program in Psychiatric Epidemiology ,NIH| ENIGMA World Aging Center ,NIH| Acute Neurocognitive-affective Predictors of Chronic Post-trauma Outcomes ,NIH| Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders ,NIH| Neurobiology of Self-Referential Processing in Posttraumatic Stress Disorder Dysfunction and Recovery ,NIH| Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data Study ,NHMRC| Neuroimaging in mental health: the quest for clinically useful biomarkers ,NIH| Atlanta Clinical and Translational Science Institute (ACTSI) Renewal ,NIH| Neural Signature of Fear Overgeneralization in Trauma Exposed Adults ,NIH| Exploring polygenic risk as a means for personalizing TBI rehabilitation ,NIH| Characterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential Processing ,NIH| Sleep disturbance, inhibition, and stress: A transdiagnostic approach to OCD ,CIHR ,NIH| Cerebral GABA and Fear Conditioning in PTSD ,NIH| EMOTIONAL REACTIVITY AND ANTERIOR BRAIN ASYMMETRY ,NIH| Neural Correlates of Location-Specific Contextual Threat Discrimination in Post-Traumatic Stress Disorders ,NIH| OST DOCTORAL TRAINING IN EMOTION RESEARCHAshley N. Clausen; Kelene A. Fercho; Molly Monsour; Seth Disner; Lauren Salminen; Courtney C. Haswell; Emily Clarke Rubright; Amanda A. Watts; M. Nicole Buckley; Adi Maron‐Katz; Anika Sierk; Antje Manthey; Benjamin Suarez‐Jimenez; Bunmi O. Olatunji; Christopher L. Averill; David Hofmann; Dick J. Veltman; Elizabeth A. Olson; Gen Li; Gina L. Forster; Henrik Walter; Jacklynn Fitzgerald; Jean Théberge; Jeffrey S. Simons; Jessica A. Bomyea; Jessie L. Frijling; John H. Krystal; Justin T. Baker; K. Luan Phan; Kerry Ressler; Laura K. M. Han; Laura Nawijn; Lauren A. M. Lebois; Lianne Schmaal; Maria Densmore; Martha E. Shenton; Mirjam van Zuiden; Murray Stein; Negar Fani; Raluca M. Simons; Richard W. J. Neufeld; Ruth Lanius; Sanne van Rooij; Saskia B.J. Koch; Serena Bonomo; Tanja Jovanovic; Terri deRoon‐Cassini; Timothy D. Ely; Vincent A. Magnotta; Xiaofu He; Chadi G. Abdallah; Amit Etkin; Christian Schmahl; Christine Larson; Isabelle M. Rosso; Jennifer Urbano Blackford; Jennifer S. Stevens; Judith K. Daniels; Julia Herzog; Milissa L. Kaufman; Miranda Olff; Richard J. Davidson; Scott R. Sponheim; Sven C. Mueller; Thomas Straube; Xi Zhu; Yuval Neria; Lee A. Baugh; James H. Cole; Paul M. Thompson; Rajendra A. Morey;Abstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan. Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. We explored estimates of brain age, as compared to chronological age, as a possible marker of accelerated aging in PTSD populations leveraging a large multi‐site sample. We identified an interaction of PTSD, age, and sex which showed young males with PTSD had a greater brain predicted age difference [PAD] than young male controls, young females with PTSD, and young females without PTSD. A similar pattern was present in middle‐aged males, but the effect of PTSD was weaker than in young adults. Male controls in the old subgroup exhibited higher brain‐PAD than old males with PTSD, old females with PTSD, and old females without PTSD.
Europe PubMed Centra... arrow_drop_down NARCIS; Brain and BehaviorArticle . 2021 . 2022Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down NARCIS; Brain and BehaviorArticle . 2021 . 2022Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 CanadaSpringer Science and Business Media LLC NIH | The Female Urinary Microb..., WT | Wellcome Trust Sanger Ins..., NHMRC | Integrated system wide ch...NIH| The Female Urinary Microbiome and Urinary Incontinence ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,NHMRC| Integrated system wide characterization of microbiota and host factors influencing intestinal colonization resistance to the healthcare pathogen Clostridium difficileKrystal Thomas-White; Samuel C. Forster; Nitin Kumar; Michelle Van Kuiken; Catherine Putonti; Mark D. Stares; Evann E. Hilt; Travis K. Price; Alan J. Wolfe; Trevor D. Lawley;pmc: PMC5908796
Metagenomic analyses have indicated that the female bladder harbors an indigenous microbiota. However, there are few cultured reference strains with sequenced genomes available for functional and experimental analyses. Here we isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women. This culture collection spans 78 species, representing approximately two thirds of the bacterial diversity within the sampled bladders, including Proteobacteria, Actinobacteria, and Firmicutes. Detailed genomic and functional comparison of the bladder microbiota to the gastrointestinal and vaginal microbiotas demonstrates similar vaginal and bladder microbiota, with functional capacities that are distinct from those observed in the gastrointestinal microbiota. Whole-genome phylogenetic analysis of bacterial strains isolated from the vagina and bladder in the same women identifies highly similar Escherichia coli, Streptococcus anginosus, Lactobacillus iners, and Lactobacillus crispatus, suggesting an interlinked female urogenital microbiota that is not only limited to pathogens but is also characteristic of health-associated commensals. The female bladder seems to harbor a poorly characterized indigenous microbiota. Here, the authors isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women, generating a culture collection representing two thirds of the bacterial diversity within the samples.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu214 citations 214 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2016 Canada, AustraliaCold Spring Harbor Laboratory WT | Core support for the Well..., NHMRC | Combined TMS-EEG for earl..., NHMRC | Characterising motor netw... +1 projectsWT| Core support for the Wellcome Trust Centre for Neuroimaging ,NHMRC| Combined TMS-EEG for early diagnosis of Alzheimer’s disease ,NHMRC| Characterising motor network connectivity to improve application of non-invasive brain stimulation in stroke ,WT| Learning and recovery of skilled finger movements.Authors: Waters, Sheena; Wiestler, Tobias; Diedrichsen, Jörn;Waters, Sheena; Wiestler, Tobias; Diedrichsen, Jörn;handle: 11541.2/131367
pmc: PMC5546115 , PMC5862803
AbstractWhat is the role of ipsilateral motor and pre-motor areas in motor learning? One view supposes that ipsilateral activity suppresses contralateral motor cortex, and thus needs to be inhibited to improve motor learning. Alternatively, the ipsilateral motor cortex may play an active role in the control and learning of unilateral hand movements. We approached this question by applying double-blind bihemispheric transcranial direct current stimulation (tDCS) over both contralateral and ipsilateral motor cortex in a between-group design during four days of unimanual explicit sequence training. Independently of whether the anode was placed over contralateral or ipsilateral motor cortex, bihemispheric stimulation yielded substantial performance gains relative to unihemispheric or sham stimulation. This performance advantage appeared to be supported by plastic changes in both hemispheres: First, we found that behavioral advantages generalized strongly to the untrained hand, suggesting that tDCS strengthened effector-independent representations. Secondly, functional imaging during speed-matched execution of trained sequences conducted 48 h after training revealed sustained, polarity-independent increases in activity in both motor cortices relative to the sham group. These results suggest a cooperative rather than competitive interaction of the two motor cortices during skill learning and suggest that bihemispheric brain stimulation during unimanual skill learning may be beneficial, because it harnesses plasticity in the ipsilateral hemisphere.Significance statementMany neurorehabilitation approaches are based on the idea that is beneficial to boost excitability in the contralateral hemisphere while attenuating that of the ipsilateral cortex to reduce interhemispheric inhibition. We observed that bihemispheric tDCS with the excitatory anode either over contralateral or ipsilateral motor cortex facilitated motor learning nearly twice as strongly as unihemispheric tDCS. These increases in motor learning were accompanied by increases in fMRI activation in both motor cortices that outlasted the stimulation period, as well as increased generalization to the untrained hand. Collectively, our findings suggest a cooperative—rather than competitive—role of the hemispheres and imply that it is most beneficial to harness plasticity in both hemispheres in neurorehabilitation of motor deficits.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 CanadaHindawi Limited NHMRC | Promoting upper limb reco..., CIHR, NSERCNHMRC| Promoting upper limb recovery after stroke in people with severe paresis. ,CIHR ,NSERCKatie P. Wadden; Sue Peters; Michael R. Borich; Jason L. Neva; Kathryn S Hayward; Cameron S. Mang; Nicholas J. Snow; Katlyn E. Brown; Todd S. Woodward; Sean K. Meehan; Lara A. Boyd;Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects of stimulation of the contralesional hemisphere at the site of the primary motor cortex (M1c) or primary somatosensory cortex (S1c) and a third group who received sham stimulation. Within each stimulation group, individuals were categorized into responders or nonresponders based on their capacity for motor skill change. Baseline diffusion tensor imaging (DTI) indexed the underlying white matter microstructure of a previously known motor learning network, named the constrained motor connectome (CMC), as well as the corticospinal tract (CST) of lesioned and nonlesioned hemispheres. Across practice, there were no differential group effects. However, when categorized as responders vs. nonresponders using change in motor behaviour, we demonstrated a significant difference in CMC microstructural properties (as measured by fractional anisotropy (FA)) for individuals in M1c and S1c groups. There were no significant differences between responders and nonresponders in clinical baseline measures or microstructural properties (FA) in the CST. The present study identifies a white matter biomarker, which extends beyond the CST, advancing our understanding of the importance of white matter networks for motor after stroke.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2012 Canada, Italy, United KingdomSAGE Publications CIHR, NHMRC | Prevention of Stroke Caus...CIHR ,NHMRC| Prevention of Stroke Caused by Carotid AtherosclerosisAnne L. Abbott; Mark A. Adelman; Andrei V. Alexandrov; Henry J.M. Barnett; Jonathan Beard; Peter R.F. Bell; Martin Björck; David Blacker; Clifford J. Buckley; Richard P. Cambria; Anthony J. Comerota; E. Sander Connolly; Alun H. Davies; Hans-Henning Eckstein; Rishad Faruqi; Gustav Fraedrich; Peter Gloviczki; Graeme J. Hankey; Robert E. Harbaugh; Eitan Heldenberg; Steven J. Kittner; Timothy Kleinig; Dimitri P. Mikhailidis; Wesley S. Moore; Ross Naylor; Andrew N. Nicolaides; Kosmas I. Paraskevas; David M. Pelz; James W. Prichard; Grant Purdie; Jean-Baptiste Ricco; Thomas S. Riles; Peter M. Rothwell; Peter Sandercock; Henrik Sillesen; J. David Spence; Francesco Spinelli; Aaron Tan; Ankur Thapar; Frank J. Veith; Wei Zhou;pmc: PMC3345362
AbstractIn recent years, many important discoveries have been made to challenge current policy, guidelines, and practice regarding how best to prevent stroke associated with atherosclerotic stenosis of the origin of the internal carotid artery. The United States Center for Medicare and Medicaid Services (CMS), for instance, is calling for expert advice as to whether its current policies should be modified. Using a thorough review of literature, 41 leading academic stroke‐prevention clinicians from the United States and other countries, have united to advise CMS not to extend current reimbursement indications for carotid angioplasty/stenting (CAS) to patients with asymptomatic carotid stenosis or to patients with symptomatic carotid stenosis considered to be at ``low or standard risk from carotid endarterectomy (CEA).'' It was concluded that such expansion of reimbursement indications would have disastrous health and economic consequences for the United States and any other country that may follow such inappropriate action. This was an international effort because the experts to best advise CMS are relatively few and scattered around the world. In addition, US health policy, practice, and research have tended to have strong influences on other countries.
Europe PubMed Centra... arrow_drop_down European Journal of Vascular and Endovascular Surgery; Oxford University Research ArchiveOther literature type . Article . 2012 . 2016License: Elsevier Non-CommercialOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveBrain and BehaviorArticle . 2012License: Wiley Online Library User AgreementData sources: CrossrefOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveOxford University Research Archive; VascularOther literature type . Article . 2012 . 2016License: SAGE TDMEuropean Journal of Vascular and Endovascular SurgeryArticleLicense: Elsevier Non-CommercialData sources: UnpayWallEuropean Journal of Vascular and Endovascular SurgeryArticle . 2012Data sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu30 citations 30 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down European Journal of Vascular and Endovascular Surgery; Oxford University Research ArchiveOther literature type . Article . 2012 . 2016License: Elsevier Non-CommercialOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveBrain and BehaviorArticle . 2012License: Wiley Online Library User AgreementData sources: CrossrefOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveOxford University Research Archive; VascularOther literature type . Article . 2012 . 2016License: SAGE TDMEuropean Journal of Vascular and Endovascular SurgeryArticleLicense: Elsevier Non-CommercialData sources: UnpayWallEuropean Journal of Vascular and Endovascular SurgeryArticle . 2012Data sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Canada, United KingdomSpringer Science and Business Media LLC NHMRC | Intervention to reduce th...NHMRC| Intervention to reduce the risk of diabetic retinopathy and early adverse retinal changes in type 1 diabetesBenitez-Aguirre, Paul Z.; Wong, Tien Y.; Craig, Maria E.; Davis, Elizabeth A.; Cotterill, Andrew; Couper, Jennifer J.; Cameron, Fergus J.; Mahmud, Farid H.; Jones, Tim W.; Hodgson, Lauren A.B.; Dalton, R. Neil; Dunger, David B.; Donaghue, Kim C.; Marshall, Sally; Armitage, Jane; Bingley, Polly; Van’t Hoff, William; Daneman, Denis; Neil, Andrew; Deanfield, John; Verge, Charles; Bergman, Phil; Rodda, Christine; Marcovecchio, M. Loredana; Chiesa, Scott; Acerini, Carlo; Ackland, Fran; Anand, Binu; Barrett, Tim;pmid: 29396691
pmc: PMC6447498
AIMS/HYPOTHESIS: We examined the hypothesis that elevation in urinary albumin creatinine ratio (ACR) in adolescents with type 1 diabetes is associated with abnormal retinal vascular geometry (RVG) phenotypes.METHODS: A cross-sectional study at baseline of the relationship between ACR within the normoalbuminuric range and RVG in 963 adolescents aged 14.4 ± 1.6 years with type 1 diabetes (median duration 6.5 years) screened for participation in AdDIT. A validated algorithm was used to categorise log10 ACR into tertiles: upper tertile ACR was defined as 'high-risk' for future albuminuria and the lower two tertiles were deemed 'low-risk'. RVG analysis, using a semi-automated computer program, determined retinal vascular calibres (standard and extended zones) and tortuosity. RVG measures were analysed continuously and categorically (in quintiles: Q1-Q5) for associations with log10 ACR and ACR risk groups.RESULTS: Greater log10 ACR was associated with narrower vessel calibres and greater tortuosity. The high-risk group was more likely to have extended zone vessel calibres in the lowest quintile (arteriolar Q1 vs Q2-Q5: OR 1.67 [95% CI 1.17, 2.38] and venular OR 1.39 [0.98, 1.99]) and tortuosity in the highest quintile (Q5 vs Q1-Q4: arteriolar OR 2.05 [1.44, 2.92] and venular OR 2.38 [1.67, 3.40]). The effects of retinal vascular calibres and tortuosity were additive such that the participants with the narrowest and most tortuous vessels were more likely to be in the high-risk group (OR 3.32 [1.84, 5.96]). These effects were independent of duration, blood pressure, BMI and blood glucose control.CONCLUSIONS/INTERPRETATION: Higher ACR in adolescents is associated with narrower and more tortuous retinal vessels. Therefore, RVG phenotypes may serve to identify populations at high risk of diabetes complications during adolescence and well before onset of clinical diabetes complications.
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For further information contact us at helpdesk@openaire.eu17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2016 Canada EnglishNature Publishing Group NIH | Administrative Core, UKRI | MRC Centre for Reproducti..., NIH | Characterization of the m... +4 projectsNIH| Administrative Core ,UKRI| MRC Centre for Reproductive Health ,NIH| Characterization of the macrophage-derived regenerative signals in intestine ,WT| The Metastatic Cascade: Macrophages Lead the Way. ,NIH| Differentiating Radio-sensitivities Among Intestinal Stem Cell Pools ,NIH| Paul Calabresi Career Development Award for Clinical Oncology (K12) ,NHMRC| The influence of a-actinin-3 on muscle structure, metabolism, performance and response to diet and diseaseSubhrajit Saha; Evelyn Aranda; Yoku Hayakawa; Payel Bhanja; Safinur Atay; N Patrik Brodin; Jiufeng Li; Samuel Asfaha; Laibin Liu; Yagnesh Tailor; Jinghang Zhang; Andrew K. Godwin; Wolfgang A. Tome; Timothy C. Wang; Chandan Guha; Jeffrey W. Pollard;pmc: PMC5065628
pmid: 27734833
WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and role in intestinal stem cell (ISC) and epithelial repair remains unknown. Macrophages are a major constituent of the intestinal stroma. Here, we analyse the role of macrophage-derived WNT in intestinal repair in mice by inhibiting their release using a macrophage-restricted ablation of Porcupine, a gene essential for WNT synthesis. Such Porcn-depleted mice have normal intestinal morphology but are hypersensitive to radiation injury in the intestine compared with wild-type (WT) littermates. Porcn-null mice are rescued from radiation lethality by treatment with WT but not Porcn-null bone marrow macrophage-conditioned medium (CM). Depletion of extracellular vesicles (EV) from the macrophage CM removes WNT function and its ability to rescue ISCs from radiation lethality. Therefore macrophage-derived EV-packaged WNTs are essential for regenerative response of intestine against radiation. The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intestinal repair.
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For further information contact us at helpdesk@openaire.eu137 citations 137 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, Canada, Italy, Denmark, FranceOvid Technologies (Wolters Kluwer Health) NIH | Institutional Clinical an..., NIH | Channelopathy-Associated ..., NIH | The Intellectual and Deve... +2 projectsNIH| Institutional Clinical and Translational Science Award ,NIH| Channelopathy-Associated Epilepsy Research Center ,NIH| The Intellectual and Developmental Disabilities Research Center at CHOP/Penn ,NIH| Joint analysis of genomic and electronic medical record data to assess outcomes and drug response in pediatric epilepsies ,NHMRC| Melanoma diagnosis, and the effect of screening on depth of invasion of melanoma.Johannesen K. M.; Gardella E.; Gjerulfsen C. E.; Bayat A.; Rouhl R. P. W.; Reijnders M.; Whalen S.; Keren B.; Buratti J.; Courtin T.; Wierenga K. J.; Isidor B.; Piton A.; Faivre L.; Garde A.; Moutton S.; Tran-Mau-Them F.; Denomme-Pichon A. -S.; Coubes C.; Larson A.; Esser M. J.; Appendino J. P.; Al-Hertani W.; Gamboni B.; Mampel A.; Mayorga L.; Orsini A.; Bonuccelli A.; Suppiej A.; Van-Gils J.; Vogt J.; Damioli S.; Giordano L.; Moortgat S.; Wirrell E.; Hicks S.; Kini U.; Noble N.; Stewart H.; Asakar S.; Cohen J. S.; Naidu S. R.; Collier A.; Brilstra E. H.; Li M. H.; Brew C.; Bigoni S.; Ognibene D.; Ballardini E.; Ruivenkamp C.; Faggioli R.; Afenjar A.; Rodriguez D.; Bick D.; Segal D.; Coman D.; Gunning B.; Devinsky O.; Demmer L. A.; Grebe T.; Pruna D.; Cursio I.; Greenhalgh L.; Graziano C.; Singh R. R.; Cantalupo G.; Willems M.; Yoganathan S.; Goes F.; Leventer R. J.; Colavito D.; Olivotto S.; Scelsa B.; Andrade A. V.; Ratke K.; Tokarz F.; Khan A. S.; Ormieres C.; Benko W.; Keough K.; Keros S.; Hussain S.; Franques A.; Varsalone F.; Gronborg S.; Mignot C.; Heron D.; Nava C.; Isapof A.; Borlot F.; Whitney R.; Ronan A.; Foulds N.; Somorai M.; Brandsema J.; Helbig K. L.; Helbig I.; Ortiz-Gonzalez X. R.; Dubbs H.; Vitobello A.; Anderson M.; Spadafore D.; Hunt D.; Moller R. S.; Rubboli G.;handle: 11562/1063816 , 11392/2475339
International audience; Background and Objectives Purine-rich element-binding protein A ( PURA ) gene encodes Pur-α, a conserved protein essential for normal postnatal brain development. Recently, a PURA syndrome characterized by intellectual disability, hypotonia, epilepsy, and dysmorphic features was suggested. The aim of this study was to define and expand the phenotypic spectrum of PURA syndrome by collecting data, including EEG, from a large cohort of affected patients. Methods Data on unpublished and published cases were collected through the PURA Syndrome Foundation and the literature. Data on clinical, genetic, neuroimaging, and neurophysiologic features were obtained. Results A cohort of 142 patients was included. Characteristics of the PURA syndrome included neonatal hypotonia, feeding difficulties, and respiratory distress. Sixty percent of the patients developed epilepsy with myoclonic, generalized tonic-clonic, focal seizures, and/or epileptic spasms. EEG showed generalized, multifocal, or focal epileptic abnormalities. Lennox-Gastaut was the most common epilepsy syndrome. Drug refractoriness was common: 33.3% achieved seizure freedom. We found 97 pathogenic variants in PURA without any clear genotype-phenotype associations. Discussion The PURA syndrome presents with a developmental and epileptic encephalopathy with characteristics recognizable from neonatal age, which should prompt genetic screening. Sixty percent have drug-resistant epilepsy with focal or generalized seizures. We collected more than 90 pathogenic variants without observing overt genotype-phenotype associations.
Archivio istituziona... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaUniversity of Southern Denmark Research OutputArticle . 2021Data sources: University of Southern Denmark Research OutputIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Archivio istituziona... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaUniversity of Southern Denmark Research OutputArticle . 2021Data sources: University of Southern Denmark Research OutputIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Turkey, Canada, ItalySAGE Publications NHMRC | Depressive and bipolar di...NHMRC| Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovationsGordon Parker; Gabriela Tavella; Glenda MacQueen; Michael Berk; Heinz Grunze; Thilo Deckersbach; David L. Dunner; Martha Sajatovic; Jay D. Amsterdam; Terence A. Ketter; Lakshmi N. Yatham; Lars Vedel Kessing; Darryl Bassett; Mark Zimmerman; Kostas N. Fountoulakis; Anne Duffy; Martin Alda; Cynthia V. Calkin; Verinder Sharma; Amit Anand; Manpreet K. Singh; Tomas Hajek; Philip Boyce; Benicio N. Frey; David J. Castle; Allan H. Young; Eduard Vieta; Janusz K. Rybakowski; Holly A. Swartz; Ayal Schaffer; Greg Murray; Adam Bayes; Raymond W. Lam; Emre Bora; Robert M. Post; Michael J. Ostacher; Beny Lafer; Anthony J. Cleare; Katherine E. Burdick; Claire O'Donovan; Abigail Ortiz; Chantal Henry; Shigenobu Kanba; Joshua D. Rosenblat; Sagar V. Parikh; David J. Bond; Michael F. Grunebaum; Sophia Frangou; Joseph F. Goldberg; Margo Orum; David N. Osser; Mark A. Frye; Roger S. McIntyre; Andrea Fagiolini; Vijaya Manicavasagar; Gabrielle A. Carlson; Gin S Malhi;handle: 11365/1067477
Objective: To derive new criteria sets for defining manic and hypomanic episodes (and thus for defining the bipolar I and II disorders), an international Task Force was assembled and termed AREDOC reflecting its role of Assessment, Revision and Evaluation of DSM and other Operational Criteria. This paper reports on the first phase of its deliberations and interim criteria recommendations. Method: The first stage of the process consisted of reviewing Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and recent International Classification of Diseases criteria, identifying their limitations and generating modified criteria sets for further in-depth consideration. Task Force members responded to recommendations for modifying criteria and from these the most problematic issues were identified. Results: Principal issues focussed on by Task Force members were how best to differentiate mania and hypomania, how to judge ‘impairment’ (both in and of itself and allowing that functioning may sometimes improve during hypomanic episodes) and concern that rejecting some criteria (e.g. an imposed duration period) might risk false-positive diagnoses of the bipolar disorders. Conclusion: This first-stage report summarises the clinical opinions of international experts in the diagnosis and management of the bipolar disorders, allowing readers to contemplate diagnostic parameters that may influence their clinical decisions. The findings meaningfully inform subsequent Task Force stages (involving a further commentary stage followed by an empirical study) that are expected to generate improved symptom criteria for diagnosing the bipolar I and II disorders with greater precision and to clarify whether they differ dimensionally or categorically.
Australian & New Zea... arrow_drop_down Dokuz Eylul University Research Information SystemArticle . 2018Data sources: Dokuz Eylul University Research Information SystemUsiena air - Università di Siena; Australian & New Zealand Journal of PsychiatryArticle . 2018License: SAGE TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Australian & New Zea... arrow_drop_down Dokuz Eylul University Research Information SystemArticle . 2018Data sources: Dokuz Eylul University Research Information SystemUsiena air - Università di Siena; Australian & New Zealand Journal of PsychiatryArticle . 2018License: SAGE TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Canada, United KingdomFrontiers Media SA UKRI | Developing a test battery..., WT | TREAT-HD: targeting neuro..., NHMRC | A convergent approach to ... +1 projectsUKRI| Developing a test battery for evaluating treatment effects on emotional, motivational and social function in neuropsychiatry ,WT| TREAT-HD: targeting neurodegeneration in Huntington's disease ,NHMRC| A convergent approach to define the behavioural and pathophysiological signatures of neuropsychiatric symptoms ,UKRI| Development and validation of a rodent touchscreen battery for assessing motivation and affective stateAuthors: Christopher J. Heath; Christopher J. Heath; Claire O'Callaghan; Claire O'Callaghan; +9 AuthorsChristopher J. Heath; Christopher J. Heath; Claire O'Callaghan; Claire O'Callaghan; Sarah L. Mason; Benjamin U. Phillips; Lisa M. Saksida; Lisa M. Saksida; Trevor W. Robbins; Roger A. Barker; Timothy J. Bussey; Timothy J. Bussey; Barbara J. Sahakian;Copyright © 2019 Heath, O'Callaghan, Mason, Phillips, Saksida, Robbins, Barker, Bussey and Sahakian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation of promising findings between preclinical disease models and patients. Apathy is a common symptom in Huntington's disease. Due to its established genetic basis and the availability of defined animal models, this disease offers a robust translational framework for linking motivated behavior with underlying neurobiology and an ideal context in which to evaluate a quantitative, translational apathy assessment method. In this study we therefore aimed to demonstrate the validity of using touchscreen-delivered progressive ratio tasks to mirror apathy assessment in Huntington's disease patients and a representative mouse model. To do this we evaluated Huntington's disease patients (n = 23) and age-matched healthy controls (n = 20), and male R6/1 mice (n = 23) and wildtype controls (n = 29) for apathy-like behavior using touchscreen-delivered progressive ratio tasks. The primary outcome measure of the assessment was breakpoint, defined as the highest number of touchscreen responses emitted before task engagement ceased. Patients and R6/1 mice were both found to exhibit significantly reduced breakpoints relative to their respective control groups, consistent with apathy-like behavior. This performance was also not associated with motoric differences in either species. These data demonstrate the utility of touchscreen-delivered progressive ratio tasks in detecting clinically relevant motivational deficits in Huntington's disease. This approach may offer a platform from which clinically relevant mechanistic insights concerning motivation symptoms can be derived and provide an effective route for translation of promising preclinical findings into viable therapeutic interventions.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu21 citations 21 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 18 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Canada, Netherlands, BelgiumWiley NIH | Laboratory of Neuro Imagi..., NIH | Social Withdrawal Followi..., NIH | Essential Features of Neu... +17 projectsNIH| Laboratory of Neuro Imaging Resource (LONIR) ,NIH| Social Withdrawal Following Trauma Exposure: a Neuroeconomic Approach ,NIH| Essential Features of Neural Damage in Mild Traumatic Brain Injury ,NIH| Research Training Program in Psychiatric Epidemiology ,NIH| ENIGMA World Aging Center ,NIH| Acute Neurocognitive-affective Predictors of Chronic Post-trauma Outcomes ,NIH| Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders ,NIH| Neurobiology of Self-Referential Processing in Posttraumatic Stress Disorder Dysfunction and Recovery ,NIH| Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data Study ,NHMRC| Neuroimaging in mental health: the quest for clinically useful biomarkers ,NIH| Atlanta Clinical and Translational Science Institute (ACTSI) Renewal ,NIH| Neural Signature of Fear Overgeneralization in Trauma Exposed Adults ,NIH| Exploring polygenic risk as a means for personalizing TBI rehabilitation ,NIH| Characterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential Processing ,NIH| Sleep disturbance, inhibition, and stress: A transdiagnostic approach to OCD ,CIHR ,NIH| Cerebral GABA and Fear Conditioning in PTSD ,NIH| EMOTIONAL REACTIVITY AND ANTERIOR BRAIN ASYMMETRY ,NIH| Neural Correlates of Location-Specific Contextual Threat Discrimination in Post-Traumatic Stress Disorders ,NIH| OST DOCTORAL TRAINING IN EMOTION RESEARCHAshley N. Clausen; Kelene A. Fercho; Molly Monsour; Seth Disner; Lauren Salminen; Courtney C. Haswell; Emily Clarke Rubright; Amanda A. Watts; M. Nicole Buckley; Adi Maron‐Katz; Anika Sierk; Antje Manthey; Benjamin Suarez‐Jimenez; Bunmi O. Olatunji; Christopher L. Averill; David Hofmann; Dick J. Veltman; Elizabeth A. Olson; Gen Li; Gina L. Forster; Henrik Walter; Jacklynn Fitzgerald; Jean Théberge; Jeffrey S. Simons; Jessica A. Bomyea; Jessie L. Frijling; John H. Krystal; Justin T. Baker; K. Luan Phan; Kerry Ressler; Laura K. M. Han; Laura Nawijn; Lauren A. M. Lebois; Lianne Schmaal; Maria Densmore; Martha E. Shenton; Mirjam van Zuiden; Murray Stein; Negar Fani; Raluca M. Simons; Richard W. J. Neufeld; Ruth Lanius; Sanne van Rooij; Saskia B.J. Koch; Serena Bonomo; Tanja Jovanovic; Terri deRoon‐Cassini; Timothy D. Ely; Vincent A. Magnotta; Xiaofu He; Chadi G. Abdallah; Amit Etkin; Christian Schmahl; Christine Larson; Isabelle M. Rosso; Jennifer Urbano Blackford; Jennifer S. Stevens; Judith K. Daniels; Julia Herzog; Milissa L. Kaufman; Miranda Olff; Richard J. Davidson; Scott R. Sponheim; Sven C. Mueller; Thomas Straube; Xi Zhu; Yuval Neria; Lee A. Baugh; James H. Cole; Paul M. Thompson; Rajendra A. Morey;Abstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan. Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. We explored estimates of brain age, as compared to chronological age, as a possible marker of accelerated aging in PTSD populations leveraging a large multi‐site sample. We identified an interaction of PTSD, age, and sex which showed young males with PTSD had a greater brain predicted age difference [PAD] than young male controls, young females with PTSD, and young females without PTSD. A similar pattern was present in middle‐aged males, but the effect of PTSD was weaker than in young adults. Male controls in the old subgroup exhibited higher brain‐PAD than old males with PTSD, old females with PTSD, and old females without PTSD.
Europe PubMed Centra... arrow_drop_down NARCIS; Brain and BehaviorArticle . 2021 . 2022Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down NARCIS; Brain and BehaviorArticle . 2021 . 2022Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 CanadaSpringer Science and Business Media LLC NIH | The Female Urinary Microb..., WT | Wellcome Trust Sanger Ins..., NHMRC | Integrated system wide ch...NIH| The Female Urinary Microbiome and Urinary Incontinence ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,NHMRC| Integrated system wide characterization of microbiota and host factors influencing intestinal colonization resistance to the healthcare pathogen Clostridium difficileKrystal Thomas-White; Samuel C. Forster; Nitin Kumar; Michelle Van Kuiken; Catherine Putonti; Mark D. Stares; Evann E. Hilt; Travis K. Price; Alan J. Wolfe; Trevor D. Lawley;pmc: PMC5908796
Metagenomic analyses have indicated that the female bladder harbors an indigenous microbiota. However, there are few cultured reference strains with sequenced genomes available for functional and experimental analyses. Here we isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women. This culture collection spans 78 species, representing approximately two thirds of the bacterial diversity within the sampled bladders, including Proteobacteria, Actinobacteria, and Firmicutes. Detailed genomic and functional comparison of the bladder microbiota to the gastrointestinal and vaginal microbiotas demonstrates similar vaginal and bladder microbiota, with functional capacities that are distinct from those observed in the gastrointestinal microbiota. Whole-genome phylogenetic analysis of bacterial strains isolated from the vagina and bladder in the same women identifies highly similar Escherichia coli, Streptococcus anginosus, Lactobacillus iners, and Lactobacillus crispatus, suggesting an interlinked female urogenital microbiota that is not only limited to pathogens but is also characteristic of health-associated commensals. The female bladder seems to harbor a poorly characterized indigenous microbiota. Here, the authors isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women, generating a culture collection representing two thirds of the bacterial diversity within the samples.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu214 citations 214 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-018-03968-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2016 Canada, AustraliaCold Spring Harbor Laboratory WT | Core support for the Well..., NHMRC | Combined TMS-EEG for earl..., NHMRC | Characterising motor netw... +1 projectsWT| Core support for the Wellcome Trust Centre for Neuroimaging ,NHMRC| Combined TMS-EEG for early diagnosis of Alzheimer’s disease ,NHMRC| Characterising motor network connectivity to improve application of non-invasive brain stimulation in stroke ,WT| Learning and recovery of skilled finger movements.Authors: Waters, Sheena; Wiestler, Tobias; Diedrichsen, Jörn;Waters, Sheena; Wiestler, Tobias; Diedrichsen, Jörn;handle: 11541.2/131367
pmc: PMC5546115 , PMC5862803
AbstractWhat is the role of ipsilateral motor and pre-motor areas in motor learning? One view supposes that ipsilateral activity suppresses contralateral motor cortex, and thus needs to be inhibited to improve motor learning. Alternatively, the ipsilateral motor cortex may play an active role in the control and learning of unilateral hand movements. We approached this question by applying double-blind bihemispheric transcranial direct current stimulation (tDCS) over both contralateral and ipsilateral motor cortex in a between-group design during four days of unimanual explicit sequence training. Independently of whether the anode was placed over contralateral or ipsilateral motor cortex, bihemispheric stimulation yielded substantial performance gains relative to unihemispheric or sham stimulation. This performance advantage appeared to be supported by plastic changes in both hemispheres: First, we found that behavioral advantages generalized strongly to the untrained hand, suggesting that tDCS strengthened effector-independent representations. Secondly, functional imaging during speed-matched execution of trained sequences conducted 48 h after training revealed sustained, polarity-independent increases in activity in both motor cortices relative to the sham group. These results suggest a cooperative rather than competitive interaction of the two motor cortices during skill learning and suggest that bihemispheric brain stimulation during unimanual skill learning may be beneficial, because it harnesses plasticity in the ipsilateral hemisphere.Significance statementMany neurorehabilitation approaches are based on the idea that is beneficial to boost excitability in the contralateral hemisphere while attenuating that of the ipsilateral cortex to reduce interhemispheric inhibition. We observed that bihemispheric tDCS with the excitatory anode either over contralateral or ipsilateral motor cortex facilitated motor learning nearly twice as strongly as unihemispheric tDCS. These increases in motor learning were accompanied by increases in fMRI activation in both motor cortices that outlasted the stimulation period, as well as increased generalization to the untrained hand. Collectively, our findings suggest a cooperative—rather than competitive—role of the hemispheres and imply that it is most beneficial to harness plasticity in both hemispheres in neurorehabilitation of motor deficits.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/082669&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 CanadaHindawi Limited NHMRC | Promoting upper limb reco..., CIHR, NSERCNHMRC| Promoting upper limb recovery after stroke in people with severe paresis. ,CIHR ,NSERCKatie P. Wadden; Sue Peters; Michael R. Borich; Jason L. Neva; Kathryn S Hayward; Cameron S. Mang; Nicholas J. Snow; Katlyn E. Brown; Todd S. Woodward; Sean K. Meehan; Lara A. Boyd;Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects of stimulation of the contralesional hemisphere at the site of the primary motor cortex (M1c) or primary somatosensory cortex (S1c) and a third group who received sham stimulation. Within each stimulation group, individuals were categorized into responders or nonresponders based on their capacity for motor skill change. Baseline diffusion tensor imaging (DTI) indexed the underlying white matter microstructure of a previously known motor learning network, named the constrained motor connectome (CMC), as well as the corticospinal tract (CST) of lesioned and nonlesioned hemispheres. Across practice, there were no differential group effects. However, when categorized as responders vs. nonresponders using change in motor behaviour, we demonstrated a significant difference in CMC microstructural properties (as measured by fractional anisotropy (FA)) for individuals in M1c and S1c groups. There were no significant differences between responders and nonresponders in clinical baseline measures or microstructural properties (FA) in the CST. The present study identifies a white matter biomarker, which extends beyond the CST, advancing our understanding of the importance of white matter networks for motor after stroke.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1155/2019/7092496&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1155/2019/7092496&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2012 Canada, Italy, United KingdomSAGE Publications CIHR, NHMRC | Prevention of Stroke Caus...CIHR ,NHMRC| Prevention of Stroke Caused by Carotid AtherosclerosisAnne L. Abbott; Mark A. Adelman; Andrei V. Alexandrov; Henry J.M. Barnett; Jonathan Beard; Peter R.F. Bell; Martin Björck; David Blacker; Clifford J. Buckley; Richard P. Cambria; Anthony J. Comerota; E. Sander Connolly; Alun H. Davies; Hans-Henning Eckstein; Rishad Faruqi; Gustav Fraedrich; Peter Gloviczki; Graeme J. Hankey; Robert E. Harbaugh; Eitan Heldenberg; Steven J. Kittner; Timothy Kleinig; Dimitri P. Mikhailidis; Wesley S. Moore; Ross Naylor; Andrew N. Nicolaides; Kosmas I. Paraskevas; David M. Pelz; James W. Prichard; Grant Purdie; Jean-Baptiste Ricco; Thomas S. Riles; Peter M. Rothwell; Peter Sandercock; Henrik Sillesen; J. David Spence; Francesco Spinelli; Aaron Tan; Ankur Thapar; Frank J. Veith; Wei Zhou;pmc: PMC3345362
AbstractIn recent years, many important discoveries have been made to challenge current policy, guidelines, and practice regarding how best to prevent stroke associated with atherosclerotic stenosis of the origin of the internal carotid artery. The United States Center for Medicare and Medicaid Services (CMS), for instance, is calling for expert advice as to whether its current policies should be modified. Using a thorough review of literature, 41 leading academic stroke‐prevention clinicians from the United States and other countries, have united to advise CMS not to extend current reimbursement indications for carotid angioplasty/stenting (CAS) to patients with asymptomatic carotid stenosis or to patients with symptomatic carotid stenosis considered to be at ``low or standard risk from carotid endarterectomy (CEA).'' It was concluded that such expansion of reimbursement indications would have disastrous health and economic consequences for the United States and any other country that may follow such inappropriate action. This was an international effort because the experts to best advise CMS are relatively few and scattered around the world. In addition, US health policy, practice, and research have tended to have strong influences on other countries.
Europe PubMed Centra... arrow_drop_down European Journal of Vascular and Endovascular Surgery; Oxford University Research ArchiveOther literature type . Article . 2012 . 2016License: Elsevier Non-CommercialOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveBrain and BehaviorArticle . 2012License: Wiley Online Library User AgreementData sources: CrossrefOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveOxford University Research Archive; VascularOther literature type . Article . 2012 . 2016License: SAGE TDMEuropean Journal of Vascular and Endovascular SurgeryArticleLicense: Elsevier Non-CommercialData sources: UnpayWallEuropean Journal of Vascular and Endovascular SurgeryArticle . 2012Data sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu30 citations 30 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down European Journal of Vascular and Endovascular Surgery; Oxford University Research ArchiveOther literature type . Article . 2012 . 2016License: Elsevier Non-CommercialOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveBrain and BehaviorArticle . 2012License: Wiley Online Library User AgreementData sources: CrossrefOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveOxford University Research Archive; VascularOther literature type . Article . 2012 . 2016License: SAGE TDMEuropean Journal of Vascular and Endovascular SurgeryArticleLicense: Elsevier Non-CommercialData sources: UnpayWallEuropean Journal of Vascular and Endovascular SurgeryArticle . 2012Data sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Canada, United KingdomSpringer Science and Business Media LLC NHMRC | Intervention to reduce th...NHMRC| Intervention to reduce the risk of diabetic retinopathy and early adverse retinal changes in type 1 diabetesBenitez-Aguirre, Paul Z.; Wong, Tien Y.; Craig, Maria E.; Davis, Elizabeth A.; Cotterill, Andrew; Couper, Jennifer J.; Cameron, Fergus J.; Mahmud, Farid H.; Jones, Tim W.; Hodgson, Lauren A.B.; Dalton, R. Neil; Dunger, David B.; Donaghue, Kim C.; Marshall, Sally; Armitage, Jane; Bingley, Polly; Van’t Hoff, William; Daneman, Denis; Neil, Andrew; Deanfield, John; Verge, Charles; Bergman, Phil; Rodda, Christine; Marcovecchio, M. Loredana; Chiesa, Scott; Acerini, Carlo; Ackland, Fran; Anand, Binu; Barrett, Tim;pmid: 29396691
pmc: PMC6447498
AIMS/HYPOTHESIS: We examined the hypothesis that elevation in urinary albumin creatinine ratio (ACR) in adolescents with type 1 diabetes is associated with abnormal retinal vascular geometry (RVG) phenotypes.METHODS: A cross-sectional study at baseline of the relationship between ACR within the normoalbuminuric range and RVG in 963 adolescents aged 14.4 ± 1.6 years with type 1 diabetes (median duration 6.5 years) screened for participation in AdDIT. A validated algorithm was used to categorise log10 ACR into tertiles: upper tertile ACR was defined as 'high-risk' for future albuminuria and the lower two tertiles were deemed 'low-risk'. RVG analysis, using a semi-automated computer program, determined retinal vascular calibres (standard and extended zones) and tortuosity. RVG measures were analysed continuously and categorically (in quintiles: Q1-Q5) for associations with log10 ACR and ACR risk groups.RESULTS: Greater log10 ACR was associated with narrower vessel calibres and greater tortuosity. The high-risk group was more likely to have extended zone vessel calibres in the lowest quintile (arteriolar Q1 vs Q2-Q5: OR 1.67 [95% CI 1.17, 2.38] and venular OR 1.39 [0.98, 1.99]) and tortuosity in the highest quintile (Q5 vs Q1-Q4: arteriolar OR 2.05 [1.44, 2.92] and venular OR 2.38 [1.67, 3.40]). The effects of retinal vascular calibres and tortuosity were additive such that the participants with the narrowest and most tortuous vessels were more likely to be in the high-risk group (OR 3.32 [1.84, 5.96]). These effects were independent of duration, blood pressure, BMI and blood glucose control.CONCLUSIONS/INTERPRETATION: Higher ACR in adolescents is associated with narrower and more tortuous retinal vessels. Therefore, RVG phenotypes may serve to identify populations at high risk of diabetes complications during adolescence and well before onset of clinical diabetes complications.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00125-017-4538-2&type=result"></script>'); --> </script>
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