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description Publicationkeyboard_double_arrow_right Article 2015 Canada EnglishElsevier BV WT | Salience network and coor..., UKRI | Cerebral recruitment duri...WT| Salience network and coordination of brain circuits in schizophrenia. ,UKRI| Cerebral recruitment during information processing in healthy individuals and in schizophreniaPalaniyappan, Lena; Mahmood, Jenaid; Balain, Vijender; Mougin, Olivier; Gowland, Penny A.; Liddle, Peter F.;pmc: PMC4604249
pmid: 26232240
Background: Persistent formal thought disorder (FTD) is one of the most characteristic features of schizophrenia. Several neuroimaging studies report spatially distinct neuroanatomical changes in association with FTD. Given that most studies so far have employed a univariate localisation approach that obscures the study of covarying interregional relationships, the present study focussed on the multivariate systemic pattern of anatomical changes that contribute to FTD. Methods: Speech samples from nineteen medicated clinically stable schizophrenia patients and 20 healthy controls were evaluated for subtle formal thought disorder. Ultra high-field (7. T) anatomical Magnetic Resonance Imaging scans were obtained from all subjects. Multivariate morphometric patterns were identified using an independent component approach (source based morphometry). Using multiple regression analysis, the morphometric patterns predicting positive and negative FTD scores were identified. Results: Morphometric variations in grey matter predicted a substantial portion of inter-individual variance in negative but not positive FTD. A pattern of concomitant striato-insular/precuneus reduction along with frontocingular grey matter increase had a significant association with negative FTD. Conclusions: These results suggest that concomitant increase and decrease in grey matter occur in association with persistent negative thought disorder in clinically stable individuals with schizophrenia.
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For further information contact us at helpdesk@openaire.eu33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Italy, CanadaSpringer Science and Business Media LLC UKRI | The UCL Centre for Medica..., CIHR, WTUKRI| The UCL Centre for Medical Image Computing ,CIHR ,WTHareem Nisar; John Moore; Roberta Piazza; Efthymios Maneas; Elvis C. S. Chen; Terry M. Peters;AbstractPurposeThis work aims to develop a simple, anatomically and haptically realistic vascular phantom, compatible with intravascular and intracardiac ultrasound. The low-cost, dual-layered phantom bridges the gap between traditional wall-only and wall-less phantoms by showing both the vessel wall and surrounding tissue in ultrasound imaging. This phantom can better assist clinical tool training, testing of intravascular devices, blood flow studies, and validation of algorithms for intravascular and intracardiac surgical systems.MethodsPolyvinyl alcohol cryogel (PVA-c) incorporating a scattering agent was used to obtain vessel and tissue-mimicking materials. Our specific design targeted the inferior vena cava and renal bifurcations which were modelled using CAD software. A custom mould and container were 3D-printed for shaping the desired vessel wall. Three phantoms were prepared by varying both the concentrations of scattering agent as well as the number of freeze–thaw cycles to which the phantom layers were subjected during the manufacturing process. Each phantom was evaluated using ultrasound imaging using the Foresight™ ICE probe. Geometrical validation was provided by comparing CAD design to a CT scan of the phantom.ResultsThe desired vascular phantom was constructed using 2.5% and 0.05% scattering agent concentration in the vessel and tissue-mimicking layers, respectively. Imaging of the three phantoms showed that increasing the number of freeze–thaw cycles did not significantly enhance the image contrast. Comparison of the US images with their CT equivalents resulted in an average error of 0.9$${\,\mathrm{mm}}$$mmfor the lumen diameter.ConclusionThe phantom is anatomically realistic when imaged with intracardiac ultrasound and provides a smooth lumen for the ultrasound probe and catheter to manoeuvre. The vascular phantom enables validation of intravascular and intracardiac image guidance systems. The simple construction technique also provides a workflow for designing complex, multi-layered arterial phantoms.
Europe PubMed Centra... arrow_drop_down International Journal of Computer Assisted Radiology and SurgeryArticleLicense: CC BYData sources: UnpayWallArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di PisaInternational Journal of Computer Assisted Radiology and SurgeryArticle . 2020License: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down International Journal of Computer Assisted Radiology and SurgeryArticleLicense: CC BYData sources: UnpayWallArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di PisaInternational Journal of Computer Assisted Radiology and SurgeryArticle . 2020License: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, Italy, Netherlands, Spain, Belgium, Canada, Netherlands, Belgium, Netherlands, Italy, Netherlands, Italy, United Kingdom, Germany, ItalySpringer Science and Business Media LLC UKRI | Developing an evidence ba..., EC | MIRIADE, CIHR +3 projectsUKRI| Developing an evidence base for trials in genetic frontotemporal dementia - measures of disease onset and progression ,EC| MIRIADE ,CIHR ,WT| Bridging the gap: biophysical models of human frontotemporal lobar degeneration ,UKRI| The UK GENetic Frontotemporal dementia Initiative (UK GENFI) ,EC| PATHADSogorb-Esteve, Aitana; Nilsson, Johanna; Borroni, Barbara; Balasa, Mircea; Bargalló, Nuria; Borrego-Ecija, Sergi; de Mendonça, Alexandre; Verdelho, Ana; Maruta, Carolina; Ferreira, Catarina B; Miltenberger, Gabriel; do Couto, Frederico Simões; Gabilondo, Alazne; Galimberti, Daniela; Gorostidi, Ana; Villanua, Jorge; Cañada, Marta; Tainta, Mikel; Zulaica, Miren; Barandiaran, Myriam; Alves, Patricia; Bender, Benjamin; Wilke, Carlo; Graf, Lisa; Sanchez-Valle, Raquel; Vogels, Annick; Vandenbulcke, Mathieu; Van Damme, Philip; Bruffaerts, Rose; Poesen, Koen; Rosa-Neto, Pedro; Gauthier, Serge; Camuzat, Agnès; Brice, Alexis; Bertrand, Anne; Laforce, Robert; Funkiewiez, Aurélie; Rinaldi, Daisy; Saracino, Dario; Colliot, Olivier; Sayah, Sabrina; Prix, Catharina; Wlasich, Elisabeth; Wagemann, Olivia; Loosli, Sandra; Schönecker, Sonja; Moreno, Fermin; Hoegen, Tobias; Lombardi, Jolina; Anderl-Straub, Sarah; Rollin, Adeline; Kuchcinski, Gregory; Bertoux, Maxime; Lebouvier, Thibaud; Deramecourt, Vincent; Santiago, Beatriz; Duro, Diana; Synofzik, Matthis; Leitão, Maria João; Almeida, Maria Rosario; Tábuas-Pereira, Miguel; Afonso, Sónia; Graff, Caroline; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B; Swift, Imogen J; Vandenberghe, Rik; Finger, Elizabeth; Tagliavini, Fabrizio; Santana, Isabel; Butler, Chris R; Ducharme, Simon; Gerhard, Alexander; Danek, Adrian; Levin, Johannes; Otto, Markus; Heller, Carolin; Sorbi, Sandro; Le Ber, Isabelle; Pasquier, Florence; Gobom, Johan; Brinkmalm, Ann; Blennow, Kaj; Zetterberg, Henrik; Rohrer, Jonathan D; Initiative, GENetic FTD; Nelson, Annabel; Bocchetta, Martina; Bouzigues, Arabella; Greaves, Caroline V; Cash, David; Thomas, David L; Todd, Emily; Benotmane, Hanya; Nicholas, Jennifer; Samra, Kiran; Shafei, Rachelle; Timberlake, Carolyn; Russell, Lucy L; Cope, Thomas; Rittman, Timothy; Benussi, Alberto; Premi, Enrico; Gasparotti, Roberto; Archetti, Silvana; Gazzina, Stefano; Cantoni, Valentina; Arighi, Andrea; Fenoglio, Chiara; Peakman, Georgia; Scarpini, Elio; Fumagalli, Giorgio; Borracci, Vittoria; Rossi, Giacomina; Giaccone, Giorgio; Di Fede, Giuseppe; Caroppo, Paola; Tiraboschi, Pietro; Prioni, Sara; Redaelli, Veronica; Convery, Rhian S; Tang-Wai, David; Rogaeva, Ekaterina; Castelo-Branco, Miguel; Freedman, Morris; Keren, Ron; Black, Sandra; Mitchell, Sara; Shoesmith, Christen; Bartha, Robart; Rademakers, Rosa; van Swieten, John C; Poos, Jackie; Papma, Janne M; Giannini, Lucia; van Minkelen, Rick; Pijnenburg, Yolande; Nacmias, Benedetta; Ferrari, Camilla; Polito, Cristina; Lombardi, Gemma; Bessi, Valentina; Seelaar, Harro; Veldsman, Michele; Andersson, Christin; Thonberg, Hakan; Öijerstedt, Linn; Jelic, Vesna; Thompson, Paul; Langheinrich, Tobias; Lladó, Albert; Antonell, Anna; Olives, Jaume;handle: 2445/202137 , 11572/357782 , 2158/1286404 , 10067/1899560151162165141 , 2434/943676 , 11379/563127
pmid: 36045450
pmc: PMC9429339
handle: 2445/202137 , 11572/357782 , 2158/1286404 , 10067/1899560151162165141 , 2434/943676 , 11379/563127
pmid: 36045450
pmc: PMC9429339
Abstract Background Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT. Impaired synaptic health is a common mechanism in all three genetic variants, so developing fluid biomarkers of this process could be useful as a readout of cellular dysfunction within therapeutic trials. Methods A total of 193 cerebrospinal fluid (CSF) samples from the GENetic FTD Initiative including 77 presymptomatic (31 C9orf72, 23 GRN, 23 MAPT) and 55 symptomatic (26 C9orf72, 17 GRN, 12 MAPT) mutation carriers as well as 61 mutation-negative controls were measured using a microflow LC PRM-MS set-up targeting 15 synaptic proteins: AP-2 complex subunit beta, complexin-2, beta-synuclein, gamma-synuclein, 14–3-3 proteins (eta, epsilon, zeta/delta), neurogranin, Rab GDP dissociation inhibitor alpha (Rab GDI alpha), syntaxin-1B, syntaxin-7, phosphatidylethanolamine-binding protein 1 (PEBP-1), neuronal pentraxin receptor (NPTXR), neuronal pentraxin 1 (NPTX1), and neuronal pentraxin 2 (NPTX2). Mutation carrier groups were compared to each other and to controls using a bootstrapped linear regression model, adjusting for age and sex. Results CSF levels of eight proteins were increased only in symptomatic MAPT mutation carriers (compared with controls) and not in symptomatic C9orf72 or GRN mutation carriers: beta-synuclein, gamma-synuclein, 14–3-3-eta, neurogranin, Rab GDI alpha, syntaxin-1B, syntaxin-7, and PEBP-1, with three other proteins increased in MAPT mutation carriers compared with the other genetic groups (AP-2 complex subunit beta, complexin-2, and 14–3-3 zeta/delta). In contrast, CSF NPTX1 and NPTX2 levels were affected in all three genetic groups (decreased compared with controls), with NPTXR concentrations being affected in C9orf72 and GRN mutation carriers only (decreased compared with controls). No changes were seen in the CSF levels of these proteins in presymptomatic mutation carriers. Concentrations of the neuronal pentraxins were correlated with brain volumes in the presymptomatic period for the C9orf72 and GRN groups, suggesting that they become abnormal in proximity to symptom onset. Conclusions Differential synaptic impairment is seen in the genetic forms of FTD, with abnormalities in multiple measures in those with MAPT mutations, but only changes in neuronal pentraxins within the GRN and C9orf72 mutation groups. Such markers may be useful in future trials as measures of synaptic dysfunction, but further work is needed to understand how these markers change throughout the course of the disease.
IRIS - Institutional... arrow_drop_down NARCIS; Alzheimer’s Research & TherapyArticle . 2022Institutional Repository Universiteit AntwerpenArticle . 2022Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert IRIS - Institutional... arrow_drop_down NARCIS; Alzheimer’s Research & TherapyArticle . 2022Institutional Repository Universiteit AntwerpenArticle . 2022Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaMDPI AG UKRI | AlwaysCleanUKRI| AlwaysCleanAuthors: Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;pandemic n = 3197) from mental health agencies across Ontario, Canada using the interRAI Child and Youth Mental Health assessment. Our findings revealed no increased incidence of witnessing domestic violence nor experiencing physical, sexual, or emotional abuse. Further, there were no increases in the risk of self-harm and suicide, anxiety, or depression among our sample of clinically referred youth. Finally, results demonstrated no increase in problematic videogaming/internet use, disordered eating, or alcohol intoxication, and a decrease in cannabis use. Our findings add to the growing body of knowledge as to the impact of the COVID-19 pandemic on children and youth. Further, findings underscore the importance of understanding the nuanced impact of the pandemic on various subgroups of children, youth, and families and highlight the need for continued monitoring of outcomes for these children and youth. Throughout the COVID-19 pandemic, population surveys revealed increased levels of anxiety and depression, while findings from large-scale population data analyses have revealed mixed findings with respect to the mental health consequences for children and youth. The purpose of this study was to examine the impact of the COVID-19 pandemic on the well-being and health-compromising behaviors of adolescents (12–18 years) previously referred for mental health services. Data were collected (pre-pandemic n = 3712
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 CanadaMDPI AG UKRI | Sepsis detection wristban..., CIHRUKRI| Sepsis detection wristband from Kimal plc ,CIHRSiwen Yang; Gregor Reid; John R. G. Challis; Gregory B. Gloor; Elizabeth Asztalos; Deborah Money; Shannon Seney; Alan D. Bocking;Spontaneous preterm birth is associated with vaginal microbial dysbiosis. As certain strains of lactobacilli help restore homeostasis in non-pregnant women, the goal was to determine the effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 administered orally, twice daily for 12 weeks on the vaginal microbiota, cytokines and chemokines of low-risk pregnant women. A double-blind, placebo-controlled, randomized trial comparing probiotic lactobacilli to placebo daily was performed in 86 asymptomatic pregnant women who had an Intermediate or Bacterial Vaginosis Nugent score at 13 weeks. After drop outs, 32 women receiving probiotics and 34 receiving placebo completed the study. The Nugent score returned to normal in 30% of the women in both groups at 28 weeks and was maintained until 35 weeks. The majority of subjects had normal pregnancy outcomes. Ninety-three bacterial species were detected at 13 weeks, with Lactobacillus iners, Lactobacillus crispatus, Gardnerella vaginalis and Atopobium vaginae being the most abundant across pregnancy. There was no difference in the Shannon diversity index between the probiotic and placebo groups at 13, 28 or 35 weeks. Almost all subjects consumed fermented foods and many of the organisms in the vagina are also known to be present in fermented foods. Interleukin-4 in the placebo group and Interleukin-10 in both probiotic and placebo groups increased slightly at 28 weeks but were not different at 35 weeks when compared to 13 weeks. In conclusion, this study showed no adverse issues resulting from 12 week use of probiotic Lactobacillus strains GR-1 and RC-14 during pregnancy in women at low risk for premature birth. The vaginal microbiota demonstrated flux irrespective of this oral probiotic administration.
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For further information contact us at helpdesk@openaire.eu37 citations 37 popularity Top 10% influence Average impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Germany, Canada, Belgium, Italy, Italy, Netherlands, United Kingdom, Italy, Netherlands, Portugal, Netherlands, Netherlands, United Kingdom, Belgium, ItalySpringer Science and Business Media LLC WT | Restoring brain function:..., UKRI | The UK GENetic Frontotemp...WT| Restoring brain function: from cortical microcircuits to complex behaviours in neurodegenerative disease. ,UKRI| The UK GENetic Frontotemporal dementia Initiative (UK GENFI)van der Ende, Emma L; Heller, Carolin; Papma, Janne M; Maruta, Carolina; Mead, Simon; Miltenberger, Gabriel; van Minkelen, Rick; Mitchell, Sara; Moore, Katrina; Nacmias, Benedetta; Nicholas, Jennifer; Öijerstedt, Linn; Olives, Jaume; Meeter, Lieke H; Ourselin, Sebastien; Padovani, Alessandro; Peakman, Georgia; Pievani, Michela; Polito, Cristina; Premi, Enrico; Prioni, Sara; Prix, Catharina; Rademakers, Rosa; Redaelli, Veronica; Dopper, Elise G P; Rittman, Tim; Rogaeva, Ekaterina; Rosa-Neto, Pedro; Rossi, Giacomina; Rosser, Martin; Santiago, Beatriz; Scarpini, Elio; Schönecker, Sonja; Semler, Elisa; Shafei, Rachelle; Bocchetta, Martina; Shoesmith, Christen; Tábuas-Pereira, Miguel; Tainta, Mikel; Taipa, Ricardo; Tang-Wai, David; Thomas, David L; Thompson, Paul; Thonberg, Hakan; Timberlake, Carolyn; Tiraboschi, Pietro; Todd, Emily; Todd, Emily; Van Damme, Philip; Vandenbulcke, Mathieu; Veldsman, Michele; Verdelho, Ana; Villanua, Jorge; Warren, Jason; Wilke, Carlo; Woollacott, Ione; Wlasich, Elisabeth; Cash, David; Zulaica, Miren; Graff, Caroline; Synofzik, Matthis; Moreno, Fermin; Finger, Elizabeth; Sogorb-Esteve, Aitana; Sanchez-Valle, Raquel; Vandenberghe, Rik; Laforce, Robert; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B; Butler, Chris; Ducharme, Simon; Gerhard, Alexander; Danek, Adrian; Swift, Imogen J; Levin, Johannes; Pijnenburg, Yolande A L; Otto, Markus; Borroni, Barbara; Tagliavini, Fabrizio; de Mendonça, Alexandre; Santana, Isabel; Galimberti, Daniela; Sorbi, Sandro; Zetterberg, Henrik; McFall, David; Huang, Eric; van Swieten, John C; Rohrer, Jonathan D; Seelaar, Harro; Initiative, Genetic Frontotemporal Dementia; Afonso, Sónia; Almeida, Maria Rosario; Anderl-Straub, Sarah; Andersson, Christin; Antonell, Anna; Peakman, Georgia; Archetti, Silvana; Arighi, Andrea; Balasa, Mircea; Barandiaran, Myriam; Bargalló, Nuria; Bartha, Robart; Bender, Benjamin; Benussi, Alberto; Benussi, Luisa; Bessi, Valentina; Bouzigues, Arabella; Binetti, Giuliano; Black, Sandra; Bocchetta, Martina; Borrego-Ecija, Sergi; Bras, Jose; Bruffaerts, Rose; Cañada, Marta; Cantoni, Valentina; Caroppo, Paola; Cash, David; Poos, Jackie M; Castelo-Branco, Miguel; Convery, Rhian; Cope, Thomas; Di Fede, Giuseppe; Díez, Alina; Duro, Diana; Fenoglio, Chiara; Ferrari, Camilla; Ferreira, Catarina B; Fox, Nick; Jiskoot, Lize C; Freedman, Morris; Fumagalli, Giorgio; Gabilondo, Alazne; Gasparotti, Roberto; Gauthier, Serge; Gazzina, Stefano; Giaccone, Giorgio; Gorostidi, Ana; Greaves, Caroline; Guerreiro, Rita; Panman, Jessica L; Hoegen, Tobias; Indakoetxea, Begoña; Jelic, Vesna; Karnath, Hans-Otto; Keren, Ron; Langheinrich, Tobias; Leitão, Maria João; Lladó, Albert; Lombardi, Gemma; Loosli, Sandra;handle: 11572/359771 , 10067/1909010151162165141 , 2158/1286416 , 2434/943677 , 11379/576251 , 10451/54421
pmid: 36064709
pmc: PMC9446850
handle: 11572/359771 , 10067/1909010151162165141 , 2158/1286416 , 2434/943677 , 11379/576251 , 10451/54421
pmid: 36064709
pmc: PMC9446850
BACKGROUND: Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers in cerebrospinal fluid (CSF) and plasma of presymptomatic and symptomatic genetic FTD mutation carriers. METHODS: We measured the complement proteins C1q and C3b in CSF by ELISAs in 224 presymptomatic and symptomatic GRN, C9orf72 or MAPT mutation carriers and non-carriers participating in the Genetic Frontotemporal Dementia Initiative (GENFI), a multicentre cohort study. Next, we used multiplex immunoassays to measure a panel of 14 complement proteins in plasma of 431 GENFI participants. We correlated complement protein levels with corresponding clinical and neuroimaging data, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP). RESULTS: CSF C1q and C3b, as well as plasma C2 and C3, were elevated in symptomatic mutation carriers compared to presymptomatic carriers and non-carriers. In genetic subgroup analyses, these differences remained statistically significant for C9orf72 mutation carriers. In presymptomatic carriers, several complement proteins correlated negatively with grey matter volume of FTD-related regions and positively with NfL and GFAP. In symptomatic carriers, correlations were additionally observed with disease duration and with Mini Mental State Examination and Clinical Dementia Rating scale® plus NACC Frontotemporal lobar degeneration sum of boxes scores. CONCLUSIONS: Elevated levels of CSF C1q and C3b, as well as plasma C2 and C3, demonstrate the presence of complement activation in the symptomatic stage of genetic FTD. Intriguingly, correlations with several disease measures in presymptomatic carriers suggest that complement protein levels might increase before symptom onset. Although the overlap between groups precludes their use as diagnostic markers, further research is needed to determine their potential to monitor dysregulation of the complement system in FTD. Funder: Knut och Alice Wallenbergs Stiftelse Funder: Gun och Bertil Stohnes Stiftelse Funder: Stiftelsen för Gamla Tjänarinnor Funder: UK Dementia Research Institute Funder: swedish alzheimer foundation Funder: Swedish brain foundation Funder: The Bluefield Project Funder: Stockholm Council ALF Funder: Karolinska Institutet Funder: schorling foundation Funder: Alzheimer's Society Funder: Mady Browaeys Fonds Funder: Demensfonden Funder: Stratneuro
IRIS - Institutional... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)NARCIS; Journal of NeuroinflammationArticle . 2022Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Universitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-EssenUniversidade de Lisboa: Repositório.ULOther literature type . 2022License: CC BYData sources: Universidade de Lisboa: Repositório.ULBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveJournal of NeuroinflammationArticle . 2022Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert IRIS - Institutional... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)NARCIS; Journal of NeuroinflammationArticle . 2022Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Universitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-EssenUniversidade de Lisboa: Repositório.ULOther literature type . 2022License: CC BYData sources: Universidade de Lisboa: Repositório.ULBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveJournal of NeuroinflammationArticle . 2022Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 CanadaSpringer Science and Business Media LLC UKRI | Capitalise.com - Using cl...UKRI| Capitalise.com - Using cloud data to monitor client portfolios and deliver next generation advisoryAuthors: Alexandra C. G. Smith; Claire V. Crooks;Alexandra C. G. Smith; Claire V. Crooks;Abstract Background There is a well-documented need for more responsive promotion and prevention programming for young immigrants and refugees in the context of mental health and healthy development. Incorporating the voice of newcomers in the development of promotion and prevention efforts could assist in producing culturally-relevant materials and improve program outcomes. Objective Our goal was to utilize youth voice to identify considerations for developing programming to support newcomer youths’ healthy development. Methods We employed mixed methods and analyzed data using concept mapping. A total of 37 newcomers between the ages of 14 and 22 participated in focus groups to share their ideas for creating programming that would focus on relationships and well-being. Relevant responses were collated, cleaned, and generated into unique statements, and then sorted individually by 26 youth into thematically similar categories. We used multidimensional scaling and hierarchal cluster analysis to produce a concept map. Results Six concepts, in rank order of importance, emerged as follows: create a space for sharing; discuss relational issues; teach strategies for adjusting to a new country; teach wellness skills; have feel-good activities; and plan for diversity. Conclusions Participants’ lived experience and their own attendance in programming at newcomer organizations assisted them in brainstorming what types of activities, topics, and skills would be helpful for other newcomer youth, as well as considerations for facilitators implementing such programming. Promotion and prevention efforts intended for newcomer youth may benefit by incorporating ideas from the concept map.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Argentina, CanadaSociety for Neuroscience UKRI | Plasticity-related mechan..., WTUKRI| Plasticity-related mechanisms involved in memory and pattern separation in the medial temporal lobe ,WTMagdalena Miranda; Brianne A. Kent; Juan Facundo Morici; Francisco Tomás Gallo; Noelia V. Weisstaub; Lisa M. Saksida; Timothy J. Bussey; Pedro Bekinschtein;Successful memory involves not only remembering over time but also keeping memories distinct. The ability to separate similar experiences into distinct memories is a main feature of episodic memory. Discrimination of overlapping representations has been investigated in the dentate gyrus of the hippocampus (DG), but little is known about this process in other regions such as the perirhinal cortex (Prh). We found in male rats that perirhinal brain-derived neurotrophic factor (BDNF) is required for separable storage of overlapping, but not distinct, object representations, which is identical to its role in the DG for spatial representations. Also, activity-regulated cytoskeletal-associated protein (Arc) is required for disambiguation of object memories, as measured by infusion of antisense oligonucleotides. This is the first time Arc has been implicated in the discrimination of objects with overlapping features. Although molecular mechanisms for object memory have been shown previously in Prh, these have been dependent on delay, suggesting a role specifically in memory duration. BDNF and Arc involvement were independent of delay—the same demand for memory persistence was present in all conditions— but only when discrimination of similar objects was required were these mechanisms recruited and necessary. Finally, we show that BDNF and Arc participate in the same pathway during consolidation of overlapping object memories. We provide novel evidence regarding the proteins involved in disambiguation of object memories outside the DG and suggest that, despite the anatomical differences, similar mechanisms underlie this process in the DG and Prh that are engaged depending on the similarity of the stimuli. Fil: Miranda, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Kent, Brianne A.. University of British Columbia; Canadá Fil: Morici, Juan Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; Reino Unido Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; Reino Unido Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Europe PubMed Centra... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2017License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 3 Powered bymore_vert Europe PubMed Centra... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2017License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Canada EnglishElsevier BV UKRI | A protocol for assessing ...UKRI| A protocol for assessing the effects of treatment on the function of brain networks implicated in cognitive impairment in schizophrenia and ADHDGascoyne, Lauren E.; Mullinger, Karen J.; Robson, Siân E.; Kumar, Jyothika; O'Neill, George C.; Palaniyappan, Lena; Morris, Peter G.; Liddle, Elizabeth B.; Brookes, Matthew J.; Liddle, Peter F.;pmc: PMC6078055
pmid: 30090697
The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to symptoms occurring in psychosis, including subtle disruption of motor control and aberrant appropriation of salience to external stimuli; however the pathological mechanisms are poorly understood. On account of the role beta oscillations play in mediating cognitive control, investigation of beta oscillations is potentially informative about such mechanisms. Here, we used magnetoencephalography to investigate the effect of the acetylcholinesterase-inhibitor, galantamine, on beta oscillations within the sensorimotor region during both a sensorimotor task and a relevance–modulation task in healthy participants, employing a double blind randomized placebo controlled cross-over design. In the galantamine condition, we found a significant reduction in the post-movement beta rebound in the case of executed movements and also in a planned but not executed movement. In the latter case, the effect was significantly greater following task-relevant compared with irrelevant stimuli. The results suggest that the action of galantamine reduces the influence of top-down cognitive processing relative to bottom-up perceptual processing in a manner resembling changes previously reported in schizophrenia. Highlights • Oscillatory beta rebound is reduced after administration of galantamine in MEG in healthy people. • Reduction in beta rebound occurs in both a movement task and also a movement suppression task. • The reduction in beta rebound directly relates to the relevance of the stimulus.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 Canada, Netherlands, Netherlands, Italy, Portugal, Belgium, Germany, Netherlands, Netherlands, Italy, United KingdomBMJ UKRI | Developing an evidence ba..., WT | Restoring brain function:..., UKRI | Identifying the role of n... +2 projectsUKRI| Developing an evidence base for trials in genetic frontotemporal dementia - measures of disease onset and progression ,WT| Restoring brain function: from cortical microcircuits to complex behaviours in neurodegenerative disease. ,UKRI| Identifying the role of neuroinflammation in frontotemporal dementia - a pathological and cerebrospinal fluid biomarker study ,UKRI| The UK GENetic Frontotemporal dementia Initiative (UK GENFI) ,WTHeller, Carolin; Foiani, Martha S; Shafei, Rachelle; Miltenberger, Gabriel; Maruta, Carolina; Verdelho, Ana; Afonso, Sónia; Taipa, Ricardo; Caroppo, Paola; Fede, Giuseppe Di; Giaccone, Giorgio; Prioni, Sara; Redaelli, Veronica; Van Swieten, John C; Rossi, Giacomina; Tiraboschi, Pietro; Duro, Diana; Almeida, Maria Rosario; Castelo-Branco, Miguel; Leitão, Maria João; Tabuas-Pereira, Miguel; Santiago, Beatriz; Gauthier, Serge; Rosa-Neto, Pedro; Moreno, Fermin; Veldsman, Michele; Flanagan, Toby; Prix, Catharina; Hoegen, Tobias; Wlasich, Elisabeth; Loosli, Sandra; Schonecker, Sonja; Semler, Elisa; Anderl-Straub, Sarah; Benussi, Luisa; Sanchez-Valle, Raquel; Binetti, Giuliano; Ghidoni, Roberta; Pievani, Michela; Lombardi, Gemma; Nacmias, Benedetta; Ferrari, Camilla; Bessi, Valentina; Borroni, Barbara; Laforce, Robert; Masellis, Mario; Tartaglia, Maria Carmela; Graff, Caroline; Galimberti, Daniela; Moore, Katrina; Rowe, James B; Finger, Elizabeth; Synofzik, Matthis; Vandenberghe, Rik; de Mendonca, Alexandre; Tagliavini, Fabrizio; Santana, Isabel; Ducharme, Simon; Butler, Christopher R; Gerhard, Alex; Convery, Rhian; Levin, Johannes; Danek, Adrian; Frisoni, Giovanni; Sorbi, Sandro; Otto, Markus; Heslegrave, Amanda J; Zetterberg, Henrik; Rohrer, Jonathan D; GENFI; Rossor, Martin N; Bocchetta, Martina; Warren, Jason D; Fox, Nick C; Guerreiro, Rita; Bras, Jose; Nicholas, Jennifer; Mead, Simon; Jiskoot, Lize; Meeter, Lieke; Panman, Jessica; Papma, Janne; Neason, Mollie; Minkelen, Rick van; Pijnenburg, Yolanda; Barandiaran, Myriam; Indakoetxea, Begoña; Gabilondo, Alazne; Tainta, Mikel; Arriba, Maria de; Gorostidi, Ana; Zulaica, Miren; Villanua, Jorge; Cash, David M; Diaz, Zigor; Borrego-Ecija, Sergi; Olives, Jaume; Lladó, Albert; Balasa, Mircea; Antonell, Anna; Bargallo, Nuria; Premi, Enrico; Cosseddu, Maura; Gazzina, Stefano; Thomas, David; Padovani, Alessandro; Gasparotti, Roberto; Archetti, Silvana; Black, Sandra; Mitchell, Sara; Rogaeva, Ekaterina; Freedman, Morris; Keren, Ron; Tang-Wai, David; Öijerstedt, Linn; Greaves, Caroline V; Andersson, Christin; Jelic, Vesna; Thonberg, Hakan; Arighi, Andrea; Fenoglio, Chiara; Scarpini, Elio; Fumagalli, Giorgio; Cope, Thomas; Timberlake, Carolyn; Rittman, Timothy; Woollacott, Ione Oc; Shoesmith, Christen; Bartha, Robart; Rademakers, Rosa; Wilke, Carlo; Karnarth, Hans-Otto; Bender, Benjamin; Bruffaerts, Rose; Vandamme, Philip; Vandenbulcke, Mathieu; Ferreira, Catarina B;handle: 10451/50337 , 11572/359912 , 2434/719452
pmid: 31937580
Background: There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process of FTD, but has yet to be explored as potential biomarker. Methods: Plasma GFAP and neurofilament light chain (NfL) concentration were measured in 469 individuals enrolled in the Genetic FTD Initiative: 114 C9orf72 expansion carriers (74 presymptomatic, 40 symptomatic), 119 GRN mutation carriers (88 presymptomatic, 31 symptomatic), 53 MAPT mutation carriers (34 presymptomatic, 19 symptomatic) and 183 non-carrier controls. Biomarker measures were compared between groups using linear regression models adjusted for age and sex with family membership included as random effect. Participants underwent standardised clinical assessments including the Mini-Mental State Examination (MMSE), Frontotemporal Lobar Degeneration-Clinical Dementia Rating scale and MRI. Spearman’s correlation coefficient was used to investigate the relationship of plasma GFAP to clinical and imaging measures. Results: Plasma GFAP concentration was significantly increased in symptomatic GRN mutation carriers (adjusted mean difference from controls 192.3 pg/mL, 95% CI 126.5 to 445.6), but not in those with C9orf72 expansions (9.0, –61.3 to 54.6), MAPT mutations (12.7, –33.3 to 90.4) or the presymptomatic groups. GFAP concentration was significantly positively correlated with age in both controls and the majority of the disease groups, as well as with NfL concentration. In the presymptomatic period, higher GFAP concentrations were correlated with a lower cognitive score (MMSE) and lower brain volume, while in the symptomatic period, higher concentrations were associated with faster rates of atrophy in the temporal lobe. Conclusions: Raised GFAP concentrations appear to be unique to GRN-related FTD, with levels potentially increasing just prior to symptom onset, suggesting that GFAP may be an important marker of proximity to onset, and helpful for forthcoming therapeutic prevention trials. Funder: EU Joint Programme - Neurodegenerative Disease Research; Grant(s): 2018-02754, Prefrontals VR Dnr 529-2014-7504, VR: 2015-02926 Funder: Association for Frontotemporal Degeneration; FundRef: http://dx.doi.org/10.13039/100003607 Funder: Center for Networked Biomedical Research on Neurodegenerative Disease (CIBERNED) Funder: Ontario Brain Institute; FundRef: http://dx.doi.org/10.13039/100008914 Funder: Brain Research Trust; FundRef: http://dx.doi.org/10.13039/501100000368 Funder: Alzheimer Nederland; FundRef: http://dx.doi.org/10.13039/501100010969 Funder: Weston Brain Institute; FundRef: http://dx.doi.org/10.13039/100012479 Funder: Hjärnfonden; FundRef: http://dx.doi.org/10.13039/501100003792 Funder: Swedish FTD Initiative-Schörling Foundation Funder: UK Dementia Research Institute UCL Funder: Stockholm County Council ALF Funder: Alzheimer Foundation Funder: Bluefield project Funder: Tau Consortium
Archivio Istituziona... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu111 citations 111 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 43visibility views 43 download downloads 71 Powered bymore_vert Archivio Istituziona... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2015 Canada EnglishElsevier BV WT | Salience network and coor..., UKRI | Cerebral recruitment duri...WT| Salience network and coordination of brain circuits in schizophrenia. ,UKRI| Cerebral recruitment during information processing in healthy individuals and in schizophreniaPalaniyappan, Lena; Mahmood, Jenaid; Balain, Vijender; Mougin, Olivier; Gowland, Penny A.; Liddle, Peter F.;pmc: PMC4604249
pmid: 26232240
Background: Persistent formal thought disorder (FTD) is one of the most characteristic features of schizophrenia. Several neuroimaging studies report spatially distinct neuroanatomical changes in association with FTD. Given that most studies so far have employed a univariate localisation approach that obscures the study of covarying interregional relationships, the present study focussed on the multivariate systemic pattern of anatomical changes that contribute to FTD. Methods: Speech samples from nineteen medicated clinically stable schizophrenia patients and 20 healthy controls were evaluated for subtle formal thought disorder. Ultra high-field (7. T) anatomical Magnetic Resonance Imaging scans were obtained from all subjects. Multivariate morphometric patterns were identified using an independent component approach (source based morphometry). Using multiple regression analysis, the morphometric patterns predicting positive and negative FTD scores were identified. Results: Morphometric variations in grey matter predicted a substantial portion of inter-individual variance in negative but not positive FTD. A pattern of concomitant striato-insular/precuneus reduction along with frontocingular grey matter increase had a significant association with negative FTD. Conclusions: These results suggest that concomitant increase and decrease in grey matter occur in association with persistent negative thought disorder in clinically stable individuals with schizophrenia.
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For further information contact us at helpdesk@openaire.eu33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Italy, CanadaSpringer Science and Business Media LLC UKRI | The UCL Centre for Medica..., CIHR, WTUKRI| The UCL Centre for Medical Image Computing ,CIHR ,WTHareem Nisar; John Moore; Roberta Piazza; Efthymios Maneas; Elvis C. S. Chen; Terry M. Peters;AbstractPurposeThis work aims to develop a simple, anatomically and haptically realistic vascular phantom, compatible with intravascular and intracardiac ultrasound. The low-cost, dual-layered phantom bridges the gap between traditional wall-only and wall-less phantoms by showing both the vessel wall and surrounding tissue in ultrasound imaging. This phantom can better assist clinical tool training, testing of intravascular devices, blood flow studies, and validation of algorithms for intravascular and intracardiac surgical systems.MethodsPolyvinyl alcohol cryogel (PVA-c) incorporating a scattering agent was used to obtain vessel and tissue-mimicking materials. Our specific design targeted the inferior vena cava and renal bifurcations which were modelled using CAD software. A custom mould and container were 3D-printed for shaping the desired vessel wall. Three phantoms were prepared by varying both the concentrations of scattering agent as well as the number of freeze–thaw cycles to which the phantom layers were subjected during the manufacturing process. Each phantom was evaluated using ultrasound imaging using the Foresight™ ICE probe. Geometrical validation was provided by comparing CAD design to a CT scan of the phantom.ResultsThe desired vascular phantom was constructed using 2.5% and 0.05% scattering agent concentration in the vessel and tissue-mimicking layers, respectively. Imaging of the three phantoms showed that increasing the number of freeze–thaw cycles did not significantly enhance the image contrast. Comparison of the US images with their CT equivalents resulted in an average error of 0.9$${\,\mathrm{mm}}$$mmfor the lumen diameter.ConclusionThe phantom is anatomically realistic when imaged with intracardiac ultrasound and provides a smooth lumen for the ultrasound probe and catheter to manoeuvre. The vascular phantom enables validation of intravascular and intracardiac image guidance systems. The simple construction technique also provides a workflow for designing complex, multi-layered arterial phantoms.
Europe PubMed Centra... arrow_drop_down International Journal of Computer Assisted Radiology and SurgeryArticleLicense: CC BYData sources: UnpayWallArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di PisaInternational Journal of Computer Assisted Radiology and SurgeryArticle . 2020License: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down International Journal of Computer Assisted Radiology and SurgeryArticleLicense: CC BYData sources: UnpayWallArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di PisaInternational Journal of Computer Assisted Radiology and SurgeryArticle . 2020License: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, Italy, Netherlands, Spain, Belgium, Canada, Netherlands, Belgium, Netherlands, Italy, Netherlands, Italy, United Kingdom, Germany, ItalySpringer Science and Business Media LLC UKRI | Developing an evidence ba..., EC | MIRIADE, CIHR +3 projectsUKRI| Developing an evidence base for trials in genetic frontotemporal dementia - measures of disease onset and progression ,EC| MIRIADE ,CIHR ,WT| Bridging the gap: biophysical models of human frontotemporal lobar degeneration ,UKRI| The UK GENetic Frontotemporal dementia Initiative (UK GENFI) ,EC| PATHADSogorb-Esteve, Aitana; Nilsson, Johanna; Borroni, Barbara; Balasa, Mircea; Bargalló, Nuria; Borrego-Ecija, Sergi; de Mendonça, Alexandre; Verdelho, Ana; Maruta, Carolina; Ferreira, Catarina B; Miltenberger, Gabriel; do Couto, Frederico Simões; Gabilondo, Alazne; Galimberti, Daniela; Gorostidi, Ana; Villanua, Jorge; Cañada, Marta; Tainta, Mikel; Zulaica, Miren; Barandiaran, Myriam; Alves, Patricia; Bender, Benjamin; Wilke, Carlo; Graf, Lisa; Sanchez-Valle, Raquel; Vogels, Annick; Vandenbulcke, Mathieu; Van Damme, Philip; Bruffaerts, Rose; Poesen, Koen; Rosa-Neto, Pedro; Gauthier, Serge; Camuzat, Agnès; Brice, Alexis; Bertrand, Anne; Laforce, Robert; Funkiewiez, Aurélie; Rinaldi, Daisy; Saracino, Dario; Colliot, Olivier; Sayah, Sabrina; Prix, Catharina; Wlasich, Elisabeth; Wagemann, Olivia; Loosli, Sandra; Schönecker, Sonja; Moreno, Fermin; Hoegen, Tobias; Lombardi, Jolina; Anderl-Straub, Sarah; Rollin, Adeline; Kuchcinski, Gregory; Bertoux, Maxime; Lebouvier, Thibaud; Deramecourt, Vincent; Santiago, Beatriz; Duro, Diana; Synofzik, Matthis; Leitão, Maria João; Almeida, Maria Rosario; Tábuas-Pereira, Miguel; Afonso, Sónia; Graff, Caroline; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B; Swift, Imogen J; Vandenberghe, Rik; Finger, Elizabeth; Tagliavini, Fabrizio; Santana, Isabel; Butler, Chris R; Ducharme, Simon; Gerhard, Alexander; Danek, Adrian; Levin, Johannes; Otto, Markus; Heller, Carolin; Sorbi, Sandro; Le Ber, Isabelle; Pasquier, Florence; Gobom, Johan; Brinkmalm, Ann; Blennow, Kaj; Zetterberg, Henrik; Rohrer, Jonathan D; Initiative, GENetic FTD; Nelson, Annabel; Bocchetta, Martina; Bouzigues, Arabella; Greaves, Caroline V; Cash, David; Thomas, David L; Todd, Emily; Benotmane, Hanya; Nicholas, Jennifer; Samra, Kiran; Shafei, Rachelle; Timberlake, Carolyn; Russell, Lucy L; Cope, Thomas; Rittman, Timothy; Benussi, Alberto; Premi, Enrico; Gasparotti, Roberto; Archetti, Silvana; Gazzina, Stefano; Cantoni, Valentina; Arighi, Andrea; Fenoglio, Chiara; Peakman, Georgia; Scarpini, Elio; Fumagalli, Giorgio; Borracci, Vittoria; Rossi, Giacomina; Giaccone, Giorgio; Di Fede, Giuseppe; Caroppo, Paola; Tiraboschi, Pietro; Prioni, Sara; Redaelli, Veronica; Convery, Rhian S; Tang-Wai, David; Rogaeva, Ekaterina; Castelo-Branco, Miguel; Freedman, Morris; Keren, Ron; Black, Sandra; Mitchell, Sara; Shoesmith, Christen; Bartha, Robart; Rademakers, Rosa; van Swieten, John C; Poos, Jackie; Papma, Janne M; Giannini, Lucia; van Minkelen, Rick; Pijnenburg, Yolande; Nacmias, Benedetta; Ferrari, Camilla; Polito, Cristina; Lombardi, Gemma; Bessi, Valentina; Seelaar, Harro; Veldsman, Michele; Andersson, Christin; Thonberg, Hakan; Öijerstedt, Linn; Jelic, Vesna; Thompson, Paul; Langheinrich, Tobias; Lladó, Albert; Antonell, Anna; Olives, Jaume;handle: 2445/202137 , 11572/357782 , 2158/1286404 , 10067/1899560151162165141 , 2434/943676 , 11379/563127
pmid: 36045450
pmc: PMC9429339
handle: 2445/202137 , 11572/357782 , 2158/1286404 , 10067/1899560151162165141 , 2434/943676 , 11379/563127
pmid: 36045450
pmc: PMC9429339
Abstract Background Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT. Impaired synaptic health is a common mechanism in all three genetic variants, so developing fluid biomarkers of this process could be useful as a readout of cellular dysfunction within therapeutic trials. Methods A total of 193 cerebrospinal fluid (CSF) samples from the GENetic FTD Initiative including 77 presymptomatic (31 C9orf72, 23 GRN, 23 MAPT) and 55 symptomatic (26 C9orf72, 17 GRN, 12 MAPT) mutation carriers as well as 61 mutation-negative controls were measured using a microflow LC PRM-MS set-up targeting 15 synaptic proteins: AP-2 complex subunit beta, complexin-2, beta-synuclein, gamma-synuclein, 14–3-3 proteins (eta, epsilon, zeta/delta), neurogranin, Rab GDP dissociation inhibitor alpha (Rab GDI alpha), syntaxin-1B, syntaxin-7, phosphatidylethanolamine-binding protein 1 (PEBP-1), neuronal pentraxin receptor (NPTXR), neuronal pentraxin 1 (NPTX1), and neuronal pentraxin 2 (NPTX2). Mutation carrier groups were compared to each other and to controls using a bootstrapped linear regression model, adjusting for age and sex. Results CSF levels of eight proteins were increased only in symptomatic MAPT mutation carriers (compared with controls) and not in symptomatic C9orf72 or GRN mutation carriers: beta-synuclein, gamma-synuclein, 14–3-3-eta, neurogranin, Rab GDI alpha, syntaxin-1B, syntaxin-7, and PEBP-1, with three other proteins increased in MAPT mutation carriers compared with the other genetic groups (AP-2 complex subunit beta, complexin-2, and 14–3-3 zeta/delta). In contrast, CSF NPTX1 and NPTX2 levels were affected in all three genetic groups (decreased compared with controls), with NPTXR concentrations being affected in C9orf72 and GRN mutation carriers only (decreased compared with controls). No changes were seen in the CSF levels of these proteins in presymptomatic mutation carriers. Concentrations of the neuronal pentraxins were correlated with brain volumes in the presymptomatic period for the C9orf72 and GRN groups, suggesting that they become abnormal in proximity to symptom onset. Conclusions Differential synaptic impairment is seen in the genetic forms of FTD, with abnormalities in multiple measures in those with MAPT mutations, but only changes in neuronal pentraxins within the GRN and C9orf72 mutation groups. Such markers may be useful in future trials as measures of synaptic dysfunction, but further work is needed to understand how these markers change throughout the course of the disease.
IRIS - Institutional... arrow_drop_down NARCIS; Alzheimer’s Research & TherapyArticle . 2022Institutional Repository Universiteit AntwerpenArticle . 2022Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert IRIS - Institutional... arrow_drop_down NARCIS; Alzheimer’s Research & TherapyArticle . 2022Institutional Repository Universiteit AntwerpenArticle . 2022Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaMDPI AG UKRI | AlwaysCleanUKRI| AlwaysCleanAuthors: Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;pandemic n = 3197) from mental health agencies across Ontario, Canada using the interRAI Child and Youth Mental Health assessment. Our findings revealed no increased incidence of witnessing domestic violence nor experiencing physical, sexual, or emotional abuse. Further, there were no increases in the risk of self-harm and suicide, anxiety, or depression among our sample of clinically referred youth. Finally, results demonstrated no increase in problematic videogaming/internet use, disordered eating, or alcohol intoxication, and a decrease in cannabis use. Our findings add to the growing body of knowledge as to the impact of the COVID-19 pandemic on children and youth. Further, findings underscore the importance of understanding the nuanced impact of the pandemic on various subgroups of children, youth, and families and highlight the need for continued monitoring of outcomes for these children and youth. Throughout the COVID-19 pandemic, population surveys revealed increased levels of anxiety and depression, while findings from large-scale population data analyses have revealed mixed findings with respect to the mental health consequences for children and youth. The purpose of this study was to examine the impact of the COVID-19 pandemic on the well-being and health-compromising behaviors of adolescents (12–18 years) previously referred for mental health services. Data were collected (pre-pandemic n = 3712
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 CanadaMDPI AG UKRI | Sepsis detection wristban..., CIHRUKRI| Sepsis detection wristband from Kimal plc ,CIHRSiwen Yang; Gregor Reid; John R. G. Challis; Gregory B. Gloor; Elizabeth Asztalos; Deborah Money; Shannon Seney; Alan D. Bocking;Spontaneous preterm birth is associated with vaginal microbial dysbiosis. As certain strains of lactobacilli help restore homeostasis in non-pregnant women, the goal was to determine the effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 administered orally, twice daily for 12 weeks on the vaginal microbiota, cytokines and chemokines of low-risk pregnant women. A double-blind, placebo-controlled, randomized trial comparing probiotic lactobacilli to placebo daily was performed in 86 asymptomatic pregnant women who had an Intermediate or Bacterial Vaginosis Nugent score at 13 weeks. After drop outs, 32 women receiving probiotics and 34 receiving placebo completed the study. The Nugent score returned to normal in 30% of the women in both groups at 28 weeks and was maintained until 35 weeks. The majority of subjects had normal pregnancy outcomes. Ninety-three bacterial species were detected at 13 weeks, with Lactobacillus iners, Lactobacillus crispatus, Gardnerella vaginalis and Atopobium vaginae being the most abundant across pregnancy. There was no difference in the Shannon diversity index between the probiotic and placebo groups at 13, 28 or 35 weeks. Almost all subjects consumed fermented foods and many of the organisms in the vagina are also known to be present in fermented foods. Interleukin-4 in the placebo group and Interleukin-10 in both probiotic and placebo groups increased slightly at 28 weeks but were not different at 35 weeks when compared to 13 weeks. In conclusion, this study showed no adverse issues resulting from 12 week use of probiotic Lactobacillus strains GR-1 and RC-14 during pregnancy in women at low risk for premature birth. The vaginal microbiota demonstrated flux irrespective of this oral probiotic administration.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu37 citations 37 popularity Top 10% influence Average impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Germany, Canada, Belgium, Italy, Italy, Netherlands, United Kingdom, Italy, Netherlands, Portugal, Netherlands, Netherlands, United Kingdom, Belgium, ItalySpringer Science and Business Media LLC WT | Restoring brain function:..., UKRI | The UK GENetic Frontotemp...WT| Restoring brain function: from cortical microcircuits to complex behaviours in neurodegenerative disease. ,UKRI| The UK GENetic Frontotemporal dementia Initiative (UK GENFI)van der Ende, Emma L; Heller, Carolin; Papma, Janne M; Maruta, Carolina; Mead, Simon; Miltenberger, Gabriel; van Minkelen, Rick; Mitchell, Sara; Moore, Katrina; Nacmias, Benedetta; Nicholas, Jennifer; Öijerstedt, Linn; Olives, Jaume; Meeter, Lieke H; Ourselin, Sebastien; Padovani, Alessandro; Peakman, Georgia; Pievani, Michela; Polito, Cristina; Premi, Enrico; Prioni, Sara; Prix, Catharina; Rademakers, Rosa; Redaelli, Veronica; Dopper, Elise G P; Rittman, Tim; Rogaeva, Ekaterina; Rosa-Neto, Pedro; Rossi, Giacomina; Rosser, Martin; Santiago, Beatriz; Scarpini, Elio; Schönecker, Sonja; Semler, Elisa; Shafei, Rachelle; Bocchetta, Martina; Shoesmith, Christen; Tábuas-Pereira, Miguel; Tainta, Mikel; Taipa, Ricardo; Tang-Wai, David; Thomas, David L; Thompson, Paul; Thonberg, Hakan; Timberlake, Carolyn; Tiraboschi, Pietro; Todd, Emily; Todd, Emily; Van Damme, Philip; Vandenbulcke, Mathieu; Veldsman, Michele; Verdelho, Ana; Villanua, Jorge; Warren, Jason; Wilke, Carlo; Woollacott, Ione; Wlasich, Elisabeth; Cash, David; Zulaica, Miren; Graff, Caroline; Synofzik, Matthis; Moreno, Fermin; Finger, Elizabeth; Sogorb-Esteve, Aitana; Sanchez-Valle, Raquel; Vandenberghe, Rik; Laforce, Robert; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B; Butler, Chris; Ducharme, Simon; Gerhard, Alexander; Danek, Adrian; Swift, Imogen J; Levin, Johannes; Pijnenburg, Yolande A L; Otto, Markus; Borroni, Barbara; Tagliavini, Fabrizio; de Mendonça, Alexandre; Santana, Isabel; Galimberti, Daniela; Sorbi, Sandro; Zetterberg, Henrik; McFall, David; Huang, Eric; van Swieten, John C; Rohrer, Jonathan D; Seelaar, Harro; Initiative, Genetic Frontotemporal Dementia; Afonso, Sónia; Almeida, Maria Rosario; Anderl-Straub, Sarah; Andersson, Christin; Antonell, Anna; Peakman, Georgia; Archetti, Silvana; Arighi, Andrea; Balasa, Mircea; Barandiaran, Myriam; Bargalló, Nuria; Bartha, Robart; Bender, Benjamin; Benussi, Alberto; Benussi, Luisa; Bessi, Valentina; Bouzigues, Arabella; Binetti, Giuliano; Black, Sandra; Bocchetta, Martina; Borrego-Ecija, Sergi; Bras, Jose; Bruffaerts, Rose; Cañada, Marta; Cantoni, Valentina; Caroppo, Paola; Cash, David; Poos, Jackie M; Castelo-Branco, Miguel; Convery, Rhian; Cope, Thomas; Di Fede, Giuseppe; Díez, Alina; Duro, Diana; Fenoglio, Chiara; Ferrari, Camilla; Ferreira, Catarina B; Fox, Nick; Jiskoot, Lize C; Freedman, Morris; Fumagalli, Giorgio; Gabilondo, Alazne; Gasparotti, Roberto; Gauthier, Serge; Gazzina, Stefano; Giaccone, Giorgio; Gorostidi, Ana; Greaves, Caroline; Guerreiro, Rita; Panman, Jessica L; Hoegen, Tobias; Indakoetxea, Begoña; Jelic, Vesna; Karnath, Hans-Otto; Keren, Ron; Langheinrich, Tobias; Leitão, Maria João; Lladó, Albert; Lombardi, Gemma; Loosli, Sandra;handle: 11572/359771 , 10067/1909010151162165141 , 2158/1286416 , 2434/943677 , 11379/576251 , 10451/54421
pmid: 36064709
pmc: PMC9446850
handle: 11572/359771 , 10067/1909010151162165141 , 2158/1286416 , 2434/943677 , 11379/576251 , 10451/54421
pmid: 36064709
pmc: PMC9446850
BACKGROUND: Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers in cerebrospinal fluid (CSF) and plasma of presymptomatic and symptomatic genetic FTD mutation carriers. METHODS: We measured the complement proteins C1q and C3b in CSF by ELISAs in 224 presymptomatic and symptomatic GRN, C9orf72 or MAPT mutation carriers and non-carriers participating in the Genetic Frontotemporal Dementia Initiative (GENFI), a multicentre cohort study. Next, we used multiplex immunoassays to measure a panel of 14 complement proteins in plasma of 431 GENFI participants. We correlated complement protein levels with corresponding clinical and neuroimaging data, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP). RESULTS: CSF C1q and C3b, as well as plasma C2 and C3, were elevated in symptomatic mutation carriers compared to presymptomatic carriers and non-carriers. In genetic subgroup analyses, these differences remained statistically significant for C9orf72 mutation carriers. In presymptomatic carriers, several complement proteins correlated negatively with grey matter volume of FTD-related regions and positively with NfL and GFAP. In symptomatic carriers, correlations were additionally observed with disease duration and with Mini Mental State Examination and Clinical Dementia Rating scale® plus NACC Frontotemporal lobar degeneration sum of boxes scores. CONCLUSIONS: Elevated levels of CSF C1q and C3b, as well as plasma C2 and C3, demonstrate the presence of complement activation in the symptomatic stage of genetic FTD. Intriguingly, correlations with several disease measures in presymptomatic carriers suggest that complement protein levels might increase before symptom onset. Although the overlap between groups precludes their use as diagnostic markers, further research is needed to determine their potential to monitor dysregulation of the complement system in FTD. Funder: Knut och Alice Wallenbergs Stiftelse Funder: Gun och Bertil Stohnes Stiftelse Funder: Stiftelsen för Gamla Tjänarinnor Funder: UK Dementia Research Institute Funder: swedish alzheimer foundation Funder: Swedish brain foundation Funder: The Bluefield Project Funder: Stockholm Council ALF Funder: Karolinska Institutet Funder: schorling foundation Funder: Alzheimer's Society Funder: Mady Browaeys Fonds Funder: Demensfonden Funder: Stratneuro
IRIS - Institutional... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)NARCIS; Journal of NeuroinflammationArticle . 2022Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Universitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-EssenUniversidade de Lisboa: Repositório.ULOther literature type . 2022License: CC BYData sources: Universidade de Lisboa: Repositório.ULBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveJournal of NeuroinflammationArticle . 2022Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert IRIS - Institutional... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)NARCIS; Journal of NeuroinflammationArticle . 2022Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Universitätsbibliographie, Universität Duisburg-EssenArticle . 2022Data sources: Universitätsbibliographie, Universität Duisburg-EssenUniversidade de Lisboa: Repositório.ULOther literature type . 2022License: CC BYData sources: Universidade de Lisboa: Repositório.ULBrunel University Research ArchiveArticle . 2022License: CC BYData sources: Brunel University Research ArchiveJournal of NeuroinflammationArticle . 2022Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 CanadaSpringer Science and Business Media LLC UKRI | Capitalise.com - Using cl...UKRI| Capitalise.com - Using cloud data to monitor client portfolios and deliver next generation advisoryAuthors: Alexandra C. G. Smith; Claire V. Crooks;Alexandra C. G. Smith; Claire V. Crooks;Abstract Background There is a well-documented need for more responsive promotion and prevention programming for young immigrants and refugees in the context of mental health and healthy development. Incorporating the voice of newcomers in the development of promotion and prevention efforts could assist in producing culturally-relevant materials and improve program outcomes. Objective Our goal was to utilize youth voice to identify considerations for developing programming to support newcomer youths’ healthy development. Methods We employed mixed methods and analyzed data using concept mapping. A total of 37 newcomers between the ages of 14 and 22 participated in focus groups to share their ideas for creating programming that would focus on relationships and well-being. Relevant responses were collated, cleaned, and generated into unique statements, and then sorted individually by 26 youth into thematically similar categories. We used multidimensional scaling and hierarchal cluster analysis to produce a concept map. Results Six concepts, in rank order of importance, emerged as follows: create a space for sharing; discuss relational issues; teach strategies for adjusting to a new country; teach wellness skills; have feel-good activities; and plan for diversity. Conclusions Participants’ lived experience and their own attendance in programming at newcomer organizations assisted them in brainstorming what types of activities, topics, and skills would be helpful for other newcomer youth, as well as considerations for facilitators implementing such programming. Promotion and prevention efforts intended for newcomer youth may benefit by incorporating ideas from the concept map.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Argentina, CanadaSociety for Neuroscience UKRI | Plasticity-related mechan..., WTUKRI| Plasticity-related mechanisms involved in memory and pattern separation in the medial temporal lobe ,WTMagdalena Miranda; Brianne A. Kent; Juan Facundo Morici; Francisco Tomás Gallo; Noelia V. Weisstaub; Lisa M. Saksida; Timothy J. Bussey; Pedro Bekinschtein;Successful memory involves not only remembering over time but also keeping memories distinct. The ability to separate similar experiences into distinct memories is a main feature of episodic memory. Discrimination of overlapping representations has been investigated in the dentate gyrus of the hippocampus (DG), but little is known about this process in other regions such as the perirhinal cortex (Prh). We found in male rats that perirhinal brain-derived neurotrophic factor (BDNF) is required for separable storage of overlapping, but not distinct, object representations, which is identical to its role in the DG for spatial representations. Also, activity-regulated cytoskeletal-associated protein (Arc) is required for disambiguation of object memories, as measured by infusion of antisense oligonucleotides. This is the first time Arc has been implicated in the discrimination of objects with overlapping features. Although molecular mechanisms for object memory have been shown previously in Prh, these have been dependent on delay, suggesting a role specifically in memory duration. BDNF and Arc involvement were independent of delay—the same demand for memory persistence was present in all conditions— but only when discrimination of similar objects was required were these mechanisms recruited and necessary. Finally, we show that BDNF and Arc participate in the same pathway during consolidation of overlapping object memories. We provide novel evidence regarding the proteins involved in disambiguation of object memories outside the DG and suggest that, despite the anatomical differences, similar mechanisms underlie this process in the DG and Prh that are engaged depending on the similarity of the stimuli. Fil: Miranda, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Kent, Brianne A.. University of British Columbia; Canadá Fil: Morici, Juan Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; Reino Unido Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; Reino Unido Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Europe PubMed Centra... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2017License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 3 Powered bymore_vert Europe PubMed Centra... arrow_drop_down CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y TécnicasArticle . 2017License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Canada EnglishElsevier BV UKRI | A protocol for assessing ...UKRI| A protocol for assessing the effects of treatment on the function of brain networks implicated in cognitive impairment in schizophrenia and ADHDGascoyne, Lauren E.; Mullinger, Karen J.; Robson, Siân E.; Kumar, Jyothika; O'Neill, George C.; Palaniyappan, Lena; Morris, Peter G.; Liddle, Elizabeth B.; Brookes, Matthew J.; Liddle, Peter F.;pmc: PMC6078055
pmid: 30090697
The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to symptoms occurring in psychosis, including subtle disruption of motor control and aberrant appropriation of salience to external stimuli; however the pathological mechanisms are poorly understood. On account of the role beta oscillations play in mediating cognitive control, investigation of beta oscillations is potentially informative about such mechanisms. Here, we used magnetoencephalography to investigate the effect of the acetylcholinesterase-inhibitor, galantamine, on beta oscillations within the sensorimotor region during both a sensorimotor task and a relevance–modulation task in healthy participants, employing a double blind randomized placebo controlled cross-over design. In the galantamine condition, we found a significant reduction in the post-movement beta rebound in the case of executed movements and also in a planned but not executed movement. In the latter case, the effect was significantly greater following task-relevant compared with irrelevant stimuli. The results suggest that the action of galantamine reduces the influence of top-down cognitive processing relative to bottom-up perceptual processing in a manner resembling changes previously reported in schizophrenia. Highlights • Oscillatory beta rebound is reduced after administration of galantamine in MEG in healthy people. • Reduction in beta rebound occurs in both a movement task and also a movement suppression task. • The reduction in beta rebound directly relates to the relevance of the stimulus.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC6078055&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC6078055&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 Canada, Netherlands, Netherlands, Italy, Portugal, Belgium, Germany, Netherlands, Netherlands, Italy, United KingdomBMJ UKRI | Developing an evidence ba..., WT | Restoring brain function:..., UKRI | Identifying the role of n... +2 projectsUKRI| Developing an evidence base for trials in genetic frontotemporal dementia - measures of disease onset and progression ,WT| Restoring brain function: from cortical microcircuits to complex behaviours in neurodegenerative disease. ,UKRI| Identifying the role of neuroinflammation in frontotemporal dementia - a pathological and cerebrospinal fluid biomarker study ,UKRI| The UK GENetic Frontotemporal dementia Initiative (UK GENFI) ,WTHeller, Carolin; Foiani, Martha S; Shafei, Rachelle; Miltenberger, Gabriel; Maruta, Carolina; Verdelho, Ana; Afonso, Sónia; Taipa, Ricardo; Caroppo, Paola; Fede, Giuseppe Di; Giaccone, Giorgio; Prioni, Sara; Redaelli, Veronica; Van Swieten, John C; Rossi, Giacomina; Tiraboschi, Pietro; Duro, Diana; Almeida, Maria Rosario; Castelo-Branco, Miguel; Leitão, Maria João; Tabuas-Pereira, Miguel; Santiago, Beatriz; Gauthier, Serge; Rosa-Neto, Pedro; Moreno, Fermin; Veldsman, Michele; Flanagan, Toby; Prix, Catharina; Hoegen, Tobias; Wlasich, Elisabeth; Loosli, Sandra; Schonecker, Sonja; Semler, Elisa; Anderl-Straub, Sarah; Benussi, Luisa; Sanchez-Valle, Raquel; Binetti, Giuliano; Ghidoni, Roberta; Pievani, Michela; Lombardi, Gemma; Nacmias, Benedetta; Ferrari, Camilla; Bessi, Valentina; Borroni, Barbara; Laforce, Robert; Masellis, Mario; Tartaglia, Maria Carmela; Graff, Caroline; Galimberti, Daniela; Moore, Katrina; Rowe, James B; Finger, Elizabeth; Synofzik, Matthis; Vandenberghe, Rik; de Mendonca, Alexandre; Tagliavini, Fabrizio; Santana, Isabel; Ducharme, Simon; Butler, Christopher R; Gerhard, Alex; Convery, Rhian; Levin, Johannes; Danek, Adrian; Frisoni, Giovanni; Sorbi, Sandro; Otto, Markus; Heslegrave, Amanda J; Zetterberg, Henrik; Rohrer, Jonathan D; GENFI; Rossor, Martin N; Bocchetta, Martina; Warren, Jason D; Fox, Nick C; Guerreiro, Rita; Bras, Jose; Nicholas, Jennifer; Mead, Simon; Jiskoot, Lize; Meeter, Lieke; Panman, Jessica; Papma, Janne; Neason, Mollie; Minkelen, Rick van; Pijnenburg, Yolanda; Barandiaran, Myriam; Indakoetxea, Begoña; Gabilondo, Alazne; Tainta, Mikel; Arriba, Maria de; Gorostidi, Ana; Zulaica, Miren; Villanua, Jorge; Cash, David M; Diaz, Zigor; Borrego-Ecija, Sergi; Olives, Jaume; Lladó, Albert; Balasa, Mircea; Antonell, Anna; Bargallo, Nuria; Premi, Enrico; Cosseddu, Maura; Gazzina, Stefano; Thomas, David; Padovani, Alessandro; Gasparotti, Roberto; Archetti, Silvana; Black, Sandra; Mitchell, Sara; Rogaeva, Ekaterina; Freedman, Morris; Keren, Ron; Tang-Wai, David; Öijerstedt, Linn; Greaves, Caroline V; Andersson, Christin; Jelic, Vesna; Thonberg, Hakan; Arighi, Andrea; Fenoglio, Chiara; Scarpini, Elio; Fumagalli, Giorgio; Cope, Thomas; Timberlake, Carolyn; Rittman, Timothy; Woollacott, Ione Oc; Shoesmith, Christen; Bartha, Robart; Rademakers, Rosa; Wilke, Carlo; Karnarth, Hans-Otto; Bender, Benjamin; Bruffaerts, Rose; Vandamme, Philip; Vandenbulcke, Mathieu; Ferreira, Catarina B;handle: 10451/50337 , 11572/359912 , 2434/719452
pmid: 31937580
Background: There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process of FTD, but has yet to be explored as potential biomarker. Methods: Plasma GFAP and neurofilament light chain (NfL) concentration were measured in 469 individuals enrolled in the Genetic FTD Initiative: 114 C9orf72 expansion carriers (74 presymptomatic, 40 symptomatic), 119 GRN mutation carriers (88 presymptomatic, 31 symptomatic), 53 MAPT mutation carriers (34 presymptomatic, 19 symptomatic) and 183 non-carrier controls. Biomarker measures were compared between groups using linear regression models adjusted for age and sex with family membership included as random effect. Participants underwent standardised clinical assessments including the Mini-Mental State Examination (MMSE), Frontotemporal Lobar Degeneration-Clinical Dementia Rating scale and MRI. Spearman’s correlation coefficient was used to investigate the relationship of plasma GFAP to clinical and imaging measures. Results: Plasma GFAP concentration was significantly increased in symptomatic GRN mutation carriers (adjusted mean difference from controls 192.3 pg/mL, 95% CI 126.5 to 445.6), but not in those with C9orf72 expansions (9.0, –61.3 to 54.6), MAPT mutations (12.7, –33.3 to 90.4) or the presymptomatic groups. GFAP concentration was significantly positively correlated with age in both controls and the majority of the disease groups, as well as with NfL concentration. In the presymptomatic period, higher GFAP concentrations were correlated with a lower cognitive score (MMSE) and lower brain volume, while in the symptomatic period, higher concentrations were associated with faster rates of atrophy in the temporal lobe. Conclusions: Raised GFAP concentrations appear to be unique to GRN-related FTD, with levels potentially increasing just prior to symptom onset, suggesting that GFAP may be an important marker of proximity to onset, and helpful for forthcoming therapeutic prevention trials. Funder: EU Joint Programme - Neurodegenerative Disease Research; Grant(s): 2018-02754, Prefrontals VR Dnr 529-2014-7504, VR: 2015-02926 Funder: Association for Frontotemporal Degeneration; FundRef: http://dx.doi.org/10.13039/100003607 Funder: Center for Networked Biomedical Research on Neurodegenerative Disease (CIBERNED) Funder: Ontario Brain Institute; FundRef: http://dx.doi.org/10.13039/100008914 Funder: Brain Research Trust; FundRef: http://dx.doi.org/10.13039/501100000368 Funder: Alzheimer Nederland; FundRef: http://dx.doi.org/10.13039/501100010969 Funder: Weston Brain Institute; FundRef: http://dx.doi.org/10.13039/100012479 Funder: Hjärnfonden; FundRef: http://dx.doi.org/10.13039/501100003792 Funder: Swedish FTD Initiative-Schörling Foundation Funder: UK Dementia Research Institute UCL Funder: Stockholm County Council ALF Funder: Alzheimer Foundation Funder: Bluefield project Funder: Tau Consortium
Archivio Istituziona... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/jnnp-2019-321954&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu111 citations 111 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 43visibility views 43 download downloads 71 Powered bymore_vert Archivio Istituziona... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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