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description Publicationkeyboard_double_arrow_right Article 2021 CanadaElsevier BV Aras Kayvanrad; Stephen R. Arnott; Nathan W. Churchill; Stefanie Hassel; Aditi Chemparathy; Fan Dong; Mojdeh Zamyadi; Tom Gee; Robert Bartha; Sandra E. Black; Jane M. Lawrence-Dewar; Christopher J.M. Scott; Sean P. Symons; Andrew D. Davis; Geoffrey B. Hall; Jacqueline K. Harris; Nancy J. Lobaugh; Glenda MacQueen; Cindy Woo; Stephen C. Strother;pmid: 34029737
Quality assurance (QA) is crucial in longitudinal and/or multi-site studies, which involve the collection of data from a group of subjects over time and/or at different locations. It is important to regularly monitor the performance of the scanners over time and at different locations to detect and control for intrinsic differences (e.g., due to manufacturers) and changes in scanner performance (e.g., due to gradual component aging, software and/or hardware upgrades, etc.). As part of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND), QA phantom scans were conducted approximately monthly for three to four years at 13 sites across Canada with 3T research MRI scanners. QA parameters were calculated for each scan using the functional Biomarker Imaging Research Network's (fBIRN) QA phantom and pipeline to capture between- and within-scanner variability. We also describe a QA protocol to measure the full-width-at-half-maximum (FWHM) of slice-wise point spread functions (PSF), used in conjunction with the fBIRN QA parameters. Variations in image resolution measured by the FWHM are a primary source of variance over time for many sites, as well as between sites and between manufacturers. We also identify an unexpected range of instabilities affecting individual slices in a number of scanners, which may amount to a substantial contribution of unexplained signal variance to their data. Finally, we identify a preliminary preprocessing approach to reduce this variance and/or alleviate the slice anomalies, and in a small human data set show that this change in preprocessing can have a significant impact on seed-based connectivity measurements for some individual subjects. We expect that other fMRI centres will find this approach to identifying and controlling scanner instabilities useful in similar studies.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 CanadaWiley Andrew S Moriarty; Nicholas Meader; Kym I E Snell; Richard D Riley; Lewis William Paton; Carolyn Chew-Graham; Simon Gilbody; Rachel Churchill; Robert S. Phillips; Shehzad Ali; Dean McMillan;BACKGROUND: Relapse (the re-emergence of depressive symptoms after some level of improvement but preceding recovery) and recurrence (onset of a new depressive episode after recovery) are common in depression, lead to worse outcomes and quality of life for patients and exert a high economic cost on society. Outcomes can be predicted by using multivariable prognostic models, which use information about several predictors to produce an individualised risk estimate. The ability to accurately predict relapse or recurrence while patients are well (in remission) would allow the identification of high-risk individuals and may improve overall treatment outcomes for patients by enabling more efficient allocation of interventions to prevent relapse and recurrence. \ud \ud OBJECTIVES: To summarise the predictive performance of prognostic models developed to predict the risk of relapse, recurrence, sustained remission or recovery in adults with major depressive disorder who meet criteria for remission or recovery. \ud \ud SEARCH METHODS: We searched the Cochrane Library (current issue); Ovid MEDLINE (1946 onwards); Ovid Embase (1980 onwards); Ovid PsycINFO (1806 onwards); and Web of Science (1900 onwards) up to May 2020. We also searched sources of grey literature, screened the reference lists of included studies and performed a forward citation search. There were no restrictions applied to the searches by date, language or publication status . \ud \ud SELECTION CRITERIA: We included development and external validation (testing model performance in data separate from the development data) studies of any multivariable prognostic models (including two or more predictors) to predict relapse, recurrence, sustained remission, or recovery in adults (aged 18 years and over) with remitted depression, in any clinical setting. We included all study designs and accepted all definitions of relapse, recurrence and other related outcomes. We did not specify a comparator prognostic model. \ud \ud DATA COLLECTION AND ANALYSIS: Two review authors independently screened references; extracted data (using a template based on the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies (CHARMS)); and assessed risks of bias of included studies (using the Prediction model Risk Of Bias ASsessment Tool (PROBAST)). We referred any disagreements to a third independent review author. Where we found sufficient (10 or more) external validation studies of an individual model, we planned to perform a meta-analysis of its predictive performance, specifically with respect to its calibration (how well the predicted probabilities match the observed proportions of individuals that experience the outcome) and discrimination (the ability of the model to differentiate between those with and without the outcome). Recommendations could not be qualified using the GRADE system, as guidance is not yet available for prognostic model reviews. \ud \ud MAIN RESULTS: We identified 11 eligible prognostic model studies (10 unique prognostic models). Seven were model development studies; three were model development and external validation studies; and one was an external validation-only study. Multiple estimates of performance measures were not available for any of the models and, meta-analysis was therefore not possible. Ten out of the 11 included studies were assessed as being at high overall risk of bias. Common weaknesses included insufficient sample size, inappropriate handling of missing data and lack of information about discrimination and calibration. One paper (Klein 2018) was at low overall risk of bias and presented a prognostic model including the following predictors: number of previous depressive episodes, residual depressive symptoms and severity of the last depressive episode. The external predictive performance of this model was poor (C-statistic 0.59; calibration slope 0.56; confidence intervals not reported). None of the identified studies examined the clinical utility (net benefit) of the developed model.\ud \ud AUTHORS' CONCLUSIONS: Of the 10 prognostic models identified (across 11 studies), only four underwent external validation. Most of the studies (n = 10) were assessed as being at high overall risk of bias, and the one study that was at low risk of bias presented a model with poor predictive performance. There is a need for improved prognostic research in this clinical area, with future studies conforming to current best practice recommendations for prognostic model development/validation and reporting findings in line with the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) statement.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 18visibility views 18 download downloads 87 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 CanadaOvid Technologies (Wolters Kluwer Health) Authors: Daniella C. Terenzi; Subodh Verma; David A. Hess;Daniella C. Terenzi; Subodh Verma; David A. Hess;pmid: 33626913
Scholarship@Western arrow_drop_down Arteriosclerosis Thrombosis and Vascular BiologyOther literature type . 2021Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Scholarship@Western arrow_drop_down Arteriosclerosis Thrombosis and Vascular BiologyOther literature type . 2021Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaMDPI AG UKRI | AlwaysCleanUKRI| AlwaysCleanAuthors: Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;pandemic n = 3197) from mental health agencies across Ontario, Canada using the interRAI Child and Youth Mental Health assessment. Our findings revealed no increased incidence of witnessing domestic violence nor experiencing physical, sexual, or emotional abuse. Further, there were no increases in the risk of self-harm and suicide, anxiety, or depression among our sample of clinically referred youth. Finally, results demonstrated no increase in problematic videogaming/internet use, disordered eating, or alcohol intoxication, and a decrease in cannabis use. Our findings add to the growing body of knowledge as to the impact of the COVID-19 pandemic on children and youth. Further, findings underscore the importance of understanding the nuanced impact of the pandemic on various subgroups of children, youth, and families and highlight the need for continued monitoring of outcomes for these children and youth. Throughout the COVID-19 pandemic, population surveys revealed increased levels of anxiety and depression, while findings from large-scale population data analyses have revealed mixed findings with respect to the mental health consequences for children and youth. The purpose of this study was to examine the impact of the COVID-19 pandemic on the well-being and health-compromising behaviors of adolescents (12–18 years) previously referred for mental health services. Data were collected (pre-pandemic n = 3712
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph181910184&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaBMJ Robert Smith; Sze Chai Hung; Joyce Goh; Hoi Lam Ip; Daniel Y. T. Fong; Shehzad Ali; Claire A Wilson; Kris Yuet Wan Lok;IntroductionPerinatal depression is common and can often lead to adverse health outcomes for mother and child. Multiple pharmacological and non-pharmacological treatments have been evaluated against usual care or placebo controls in meta-analyses for preventing and treating perinatal depression compared. It is not yet established which of these candidate treatments might be the optimal approach for prevention or treatment.Methods and analysisA systematic review and Bayesian network meta-analyses will be conducted. Eight electronic databases shall be searched for randomised controlled trials that have evaluated the effectiveness of treatments for prevention and/or treatment of perinatal depression. Screening of articles shall be conducted by two reviewers independently. One network meta-analysis shall evaluate the effectiveness of interventions in preventing depression during the perinatal period. A second network meta-analysis shall compare the effectiveness of treatments for depression symptoms in women with perinatal depression. Bayesian 95% credible intervals shall be used to estimate the pooled mean effect size of each treatment, and surface under cumulative ranking area will be used to rank the treatments’ effectiveness.Ethics and disseminationWe shall report our findings so that healthcare providers can make informed decisions on what might be the optimal approach for addressing perinatal depression to prevent cases and improve outcomes in those suffering from depression through knowledge exchange workshops, international conference presentations and journal article publications.PROSPERO registration numberCRD42020200081.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmjopen-2021-048764&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2021 Sweden, CanadaOxford University Press (OUP) Lydia Kapiriri; Suzanne N Kiwanuka; Godfrey Biemba; Claudia Velez; S Donya Razavi; Julia Abelson; Beverley M Essue; Marion Danis; Susan Dorr Goold; Mariam Noorulhuda; Elysée Nouvet; Lars Sandman; Iestyn Williams;Priority setting represents an even bigger challenge during public health emergencies than routine times. This is because such emergencies compete with routine programmes for the available health resources, strain health systems and shift health-care attention and resources towards containing the spread of the epidemic and treating those that fall seriously ill. This paper is part of a larger global study, the aim of which is to evaluate the degree to which national COVID-19 preparedness and response plans incorporated priority setting concepts. It provides important insights into what and how priority decisions were made in the context of a pandemic. Specifically, with a focus on a sample of 18 African countries pandemic plans, the paper aims to: (1) explore the degree to which the documented priority setting processes adhere to established quality indicators of effective priority setting and (2) examine if there is a relationship between the number of quality indicators present in the pandemic plans and the countrys economic context, health system and prior experiences with disease outbreaks. All the reviewed plans contained some aspects of expected priority setting processes but none of the national plans addressed all quality parameters. Most of the parameters were mentioned by less than 10 of the 18 country plans reviewed, and several plans identified one or two aspects of fair priority setting processes. Very few plans identified equity as a criterion for priority setting. Since the parameters are relevant to the quality of priority setting that is implemented during public health emergencies and most of the countries have pre-existing pandemic plans; it would be advisable that, for the future (if not already happening), countries consider priority setting as a critical part of their routine health emergency and disease outbreak plans. Such an approach would ensure that priority setting is integral to pandemic planning, response and recovery. Funding Agencies|McMaster University COVID-19 research fund
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For further information contact us at helpdesk@openaire.eu11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/heapol/czab113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Canada, United StatesSpringer Science and Business Media LLC Shawn N. Whitehead; Askiel Bruno; Jeffrey M. Burns; S. Thomas Carmichael; Anna Csiszar; Jodi D. Edwards; Fanny M. Elahi; Giuseppe Faraco; Douglas B. Gould; Deborah Gustafson; Vladimir Hachinski; Gary A. Rosenberg; Farzaneh A. Sorond; Andy Y. Shih; Kai Hei Tse; Zoltan Ungvari; Donna M. Wilcock; Kristen L. Zuloaga; Frank C. Barone;White matter pathologies are critically involved in the etiology of vascular cognitive impairment–dementia (VCID), Alzheimer’s disease (AD), and Alzheimer’s disease and related diseases (ADRD), and therefore need to be considered a treatable target ( Roseborough A, Hachinski V, Whitehead S. White matter degeneration - a treatable target? Roseborough et al. JAMA Neurol [Internet]. 2020 Apr 27;77(7):793–4, [1] . To help address this often-missed area of research, several workshops have been sponsored by the Leo and Anne Albert Charitable Trust since 2015, resulting in the incorporation of “The Albert Research Institute for White Matter and Cognition” in 2020. The first annual “Institute” meeting was held virtually on March 3–4, 2021. The Institute provides a forum and workspace for communication and support of the advancement of white matter science and research to better understand the evolution and prevention of dementia. It serves as a platform for young investigator development, to introduce new data and debate biology mechanisms and new ideas, and to encourage and support new research collaborations and directions to clarify how white matter changes, with other genetic and health risk factors, contribute to cognitive impairment. Similar to previous Albert Trust–sponsored workshops (Barone et al. in J Transl Med 14:1–14, [2]; Sorond et al. in GeroScience 42:81–96, [3]), established expert investigators were identified and invited to present. Opportunities to attend and present were also extended by invitation to talented research fellows and younger scientists. Also, updates on institute-funded research collaborations were provided and discussed. The summary that follows is a synopsis of topics and discussion covered in the workshop.
Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, Netherlands, Italy, Netherlands, Portugal, Canada, Italy, Germany, Italy, Netherlands, Netherlands, United Kingdom, Portugal, BelgiumElsevier BV EC | Solve-RDEC| Solve-RDSergi Borrego-Écija; Roser Sala-Llonch; John C. van Swieten; Barbara Borroni; Fermin Moreno; Mario Masellis; Carmela Tartaglia; Caroline Graff; Daniela Galimberti; Robert Laforce; James B. Rowe; Elizabeth Finger; Rik Vandenberghe; Fabrizio Tagliavini; Alexandre de Mendonça; Isabel Santana; Matthis Synofzik; Simon Ducharme; Johannes Levin; Adrian Danek; Alexander Gerhard; Markus Otto; Christopher C Butler; Giovanni B. Frisoni; Sandro Sorbi; Carolin Heller; Martina Bocchetta; David M. Cash; Rhian S Convery; Katrina M. Moore; Jonathan D. Rohrer; Raquel Sánchez-Valle; Martin N. Rossor; Nick C. Fox; Ione O.C. Woollacott; Rachelle Shafei; Caroline V. Greaves; Mollie Neason; Rita Guerreiro; Jose Bras; David L. Thomas; Jennifer M. Nicholas; Simon Mead; Lieke H.H. Meeter; Jessica L. Panman; Janne M. Papma; Rick van Minkelen; Yolande A.L. Pijnenburg; Begoña Indakoetxea; Alazne Gabilondo; Mikel TaintaMD; Maria de Arriba; Ana Gorostidi; Miren Zulaica; Jorge Villanua; Zigor Diaz; Jaume Olives; Albert Lladó; Mircea Balasa; Anna Antonell; Núria Bargalló; Enrico Premi; Maura Cosseddu; Stefano Gazzina; Alessandro Padovani; Roberto Gasparotti; Silvana Archetti; Sandra E. Black; Sara Mitchell; Ekaterina Rogaeva; Morris Freedman; Ron Keren; David F. Tang-Wai; Linn Öijerstedt; Christin Andersson; Vesna Jelic; Håkan Thonberg; Andrea Arighi; Chiara Fenoglio; Elio Scarpini; Giorgio Fumagalli; Thomas E. Cope; Carolyn Timberlake; Timothy Rittman; Christen Shoesmith; Robart Bartha; Rosa Rademakers; Carlo Wilke; Benjamin Bender; Rose Bruffaerts; Philip Vandamme; Mathieu Vandenbulcke; Carolina Maruta; C. Ferreira; Gabriel Miltenberger; Ana Verdelho; Sónia Afonso; Ricardo Taipa; Paola Caroppo; Giuseppe Di Fede; Giorgio Giaccone; Sara Prioni; Veronica Redaelli; Giacomina Rossi; Pietro Tiraboschi; Diana Duro; Maria Rosário Almeida; Miguel Castelo-Branco; Maria João Leitão; Miguel Tábuas-Pereira; Beatriz Santiago; Serge Gauthier; Pedro Rosa-Neto; Michele Veldsman; Toby Flanagan; Catharina Prix; Tobias Hoegen; Elisabeth Wlasich; Sandra V. Loosli; Sonja Schönecker; Elisa Semler; Sarah Anderl-Straub;handle: 10451/46269 , 2158/1230440 , 11379/576269 , 11572/355946 , 10400.16/2850 , 2434/902153
pmc: PMC7804836
pmid: 33418170
handle: 10451/46269 , 2158/1230440 , 11379/576269 , 11572/355946 , 10400.16/2850 , 2434/902153
pmc: PMC7804836
pmid: 33418170
The authors thank all the volunteers for their participation in this study. SBE is a recipient of the Rio-Hortega post-residency grant from the Instituto de Salud Carlos III, Spain. This study was partially funded by Fundació Marató de TV3, Spain (grant no. 20143810 to RSV). The GENFI study has been supported by the Medical Research Council UK, the Italian Ministry of Health and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, as well as other individual funding to investigators. KM has received funding from an Alzheimer’s Society PhD studentship. JDR acknowledges support from the National Institute for Health Research (NIHR) Queen Square Dementia Biomedical Research Unit and the University College London Hospitals Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre, the UK Dementia Research Institute, Alzheimer’s Research UK, the Brain Research Trust and the Wolfson Foundation. JCvS was supported by the Dioraphte Foundation grant 09-02-03-00, the Association for Frontotemporal Dementias Research Grant 2009, The Netherlands Organization for Scientific Research (NWO) grant HCMI 056-13-018, ZonMw Memorabel (Deltaplan Dementie, project number 733 051 042), Alzheimer Nederland and the Bluefield project. CG have received funding from JPND-Prefrontals VR Dnr 529-2014-7504, VR: 2015-02926, and 2018-02754, the Swedish FTD Initiative-Schörling Foundation, Alzheimer Foundation, Brain Foundation and Stockholm County Council ALF. DG has received support from the EU Joint Programme – Neurodegenerative Disease Research (JPND) and the Italian Ministry of Health (PreFrontALS) grant 733051042. JBR is funded by the Wellcome Trust (103838) and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. MM has received funding from a Canadian Institutes of Health Research operating grant and the Weston Brain Institute and Ontario Brain Institute. RV has received funding from the Mady Browaeys Fund for Research into Frontotemporal Dementia. EF has received funding from a CIHR grant #327387. JDR is an MRC Clinician Scientist (MR/M008525/1) and has received funding from the NIHR Rare Diseases Translational Research Collaboration (BRC149/NS/MH), the Bluefield Project and the Association for Frontotemporal Degeneration. MS was supported by a grant 779257 “Solve-RD” from the Horizon 2020 research and innovation programme. Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 noncarriers from the Genetic Frontotemporal dementia initiative (GENFI), with MRI structural images. We analyzed 3T MRI structural images using the FreeSurfer pipeline to calculate the whole brain cortical thickness (CTh) for each subject. We also perform a vertex-wise general linear model to assess differences between groups in the relationship between CTh and diverse covariables as gender, age, the estimated years to onset and education. We also explored differences according to TMEM106B genotype, a possible disease modifier. Whole brain CTh did not differ between carriers and noncarriers. Both groups showed age-related cortical thinning. The group-by-age interaction analysis showed that this age-related cortical thinning was significantly greater in GRN carriers in the left superior frontal cortex. TMEM106B did not significantly influence the age-related cortical thinning. Our results validate and expand previous findings suggesting an increased CTh loss associated with age and estimated proximity to symptoms onset in GRN carriers, even before the disease onset. © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
Europe PubMed Centra... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2021License: CC BY NC NDRepositório Científico do Centro Hospitalar do PortoArticle . 2021License: CC BYData sources: Repositório Científico do Centro Hospitalar do PortoFlore (Florence Research Repository)Article . 2021Data sources: Flore (Florence Research Repository)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 92visibility views 92 download downloads 135 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2021License: CC BY NC NDRepositório Científico do Centro Hospitalar do PortoArticle . 2021License: CC BYData sources: Repositório Científico do Centro Hospitalar do PortoFlore (Florence Research Repository)Article . 2021Data sources: Flore (Florence Research Repository)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaElsevier BV Shamini Selvarajah; Sophie Plante; Marsha Speevak; Andrea K. Vaags; Darren Hamelinck; Martin Butcher; Elizabeth McCready; Daria Grafodatskaya; Normand Blais; Danh Tran-Thanh; Xiaoduan Weng; Rami Nassabein; Wenda L. Greer; R. Walton; Bryan Lo; Doug Demetrick; Stephanie Santos; Bekim Sadikovic; Xiao Zhang; Tong Zhang; Tara Spence; Tracy Stockley; Harriet Feilotter; Philippe Joubert;Abstract Introduction Genotyping circulating tumor DNA (ctDNA) is a promising noninvasive clinical tool to identify the EGFR T790M resistance mutation in patients with advanced NSCLC with resistance to EGFR inhibitors. To facilitate standardization and clinical adoption of ctDNA testing across Canada, we developed a 2-phase multicenter study to standardize T790M mutation detection using plasma ctDNA testing. Methods In phase 1, commercial reference standards were distributed to participating clinical laboratories, to use their existing platforms for mutation detection. Baseline performance characteristics were established using known and blinded engineered plasma samples spiked with predetermined concentrations of T790M, L858R, and exon 19 deletion variants. In phase II, peripheral blood collected from local patients with known EGFR activating mutations and progressing on treatment were assayed for the presence of EGFR variants and concordance with a clinically validated test at the reference laboratory. Results All laboratories in phase 1 detected the variants at 0.5 % and 5.0 % allele frequencies, with no false positives. In phase 2, the concordance with the reference laboratory for detection of both the primary and resistance mutation was high, with next-generation sequencing and droplet digital polymerase chain reaction exhibiting the best overall concordance. Data also suggested that the ability to detect mutations at clinically relevant limits of detection is generally not platform-specific, but rather impacted by laboratory-specific practices. Conclusions Discrepancies among sending laboratories using the same assay suggest that laboratory-specific practices may impact performance. In addition, a negative or inconclusive ctDNA test should be followed by tumor testing when possible.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 France, Netherlands, Germany, Canada, Netherlands, Netherlands, Spain, France, Netherlands, NetherlandsWiley Jennifer Faber; Tamara Schaprian; Koyak Berkan; Kathrin Reetz; Marcondes C. França; Thiago Junqueira Ribeiro de Rezende; Jiang Hong; Weihua Liao; Bart P.C. van de Warrenburg; Judith van Gaalen; Alexandra Durr; Fanny Mochel; Paola Giunti; Hector Garcia-Moreno; L. Schoels; Holger Hengel; Matthis Synofzik; Benjamin Bender; Gülin Öz; James M. Joers; Jereon J. de Vries; Jun Suk Kang; Dagmar Timmann-Braun; Heike Jacobi; Jon Infante; Richard Joules; Sandro Romanzetti; Jörn Diedrichsen; Matthias Schmid; Robin Wolz; Thomas Klockgether;BACKGROUND: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity. OBJECTIVE: The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease. METHODS: We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers and 63 healthy controls. In addition, cervical cord cross-sectional areas were determined at 2 levels. RESULTS: The metrics of cervical spinal cord segments C3 and C2, medulla oblongata, pons, and pallidum, and the cerebellar anterior lobe were reduced in preataxic mutation carriers compared with controls. Those of cervical spinal cord segments C2 and C3, medulla oblongata, pons, midbrain, cerebellar lobules crus II and X, cerebellar white matter, and pallidum were reduced in ataxic compared with nonataxic carriers. Of all metrics studied, pontine volume showed the steepest decline across the disease course. It covaried with ataxia severity, CAG repeat length, and age. The multivariate model derived from this analysis explained 46.33% of the variance of pontine volume. CONCLUSION: Regional brain and spinal cord tissue loss in spinocerebellar ataxia type 3 starts before ataxia onset. Pontine volume appears to be the most promising imaging biomarker candidate for interventional trials that aim at slowing the progression of spinocerebellar ataxia type 3. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Contains fulltext : 244289.pdf (Publisher’s version ) (Open Access)
NARCIS arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2021Data sources: Universitätsbibliographie, Universität Duisburg-EssenPublikationsserver der RWTH Aachen UniversityArticle . 2021Data sources: Publikationsserver der RWTH Aachen Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu34 citations 34 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 21visibility views 21 download downloads 36 Powered bymore_vert NARCIS arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2021Data sources: Universitätsbibliographie, Universität Duisburg-EssenPublikationsserver der RWTH Aachen UniversityArticle . 2021Data sources: Publikationsserver der RWTH Aachen Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2021 CanadaElsevier BV Aras Kayvanrad; Stephen R. Arnott; Nathan W. Churchill; Stefanie Hassel; Aditi Chemparathy; Fan Dong; Mojdeh Zamyadi; Tom Gee; Robert Bartha; Sandra E. Black; Jane M. Lawrence-Dewar; Christopher J.M. Scott; Sean P. Symons; Andrew D. Davis; Geoffrey B. Hall; Jacqueline K. Harris; Nancy J. Lobaugh; Glenda MacQueen; Cindy Woo; Stephen C. Strother;pmid: 34029737
Quality assurance (QA) is crucial in longitudinal and/or multi-site studies, which involve the collection of data from a group of subjects over time and/or at different locations. It is important to regularly monitor the performance of the scanners over time and at different locations to detect and control for intrinsic differences (e.g., due to manufacturers) and changes in scanner performance (e.g., due to gradual component aging, software and/or hardware upgrades, etc.). As part of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND), QA phantom scans were conducted approximately monthly for three to four years at 13 sites across Canada with 3T research MRI scanners. QA parameters were calculated for each scan using the functional Biomarker Imaging Research Network's (fBIRN) QA phantom and pipeline to capture between- and within-scanner variability. We also describe a QA protocol to measure the full-width-at-half-maximum (FWHM) of slice-wise point spread functions (PSF), used in conjunction with the fBIRN QA parameters. Variations in image resolution measured by the FWHM are a primary source of variance over time for many sites, as well as between sites and between manufacturers. We also identify an unexpected range of instabilities affecting individual slices in a number of scanners, which may amount to a substantial contribution of unexplained signal variance to their data. Finally, we identify a preliminary preprocessing approach to reduce this variance and/or alleviate the slice anomalies, and in a small human data set show that this change in preprocessing can have a significant impact on seed-based connectivity measurements for some individual subjects. We expect that other fMRI centres will find this approach to identifying and controlling scanner instabilities useful in similar studies.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 CanadaWiley Andrew S Moriarty; Nicholas Meader; Kym I E Snell; Richard D Riley; Lewis William Paton; Carolyn Chew-Graham; Simon Gilbody; Rachel Churchill; Robert S. Phillips; Shehzad Ali; Dean McMillan;BACKGROUND: Relapse (the re-emergence of depressive symptoms after some level of improvement but preceding recovery) and recurrence (onset of a new depressive episode after recovery) are common in depression, lead to worse outcomes and quality of life for patients and exert a high economic cost on society. Outcomes can be predicted by using multivariable prognostic models, which use information about several predictors to produce an individualised risk estimate. The ability to accurately predict relapse or recurrence while patients are well (in remission) would allow the identification of high-risk individuals and may improve overall treatment outcomes for patients by enabling more efficient allocation of interventions to prevent relapse and recurrence. \ud \ud OBJECTIVES: To summarise the predictive performance of prognostic models developed to predict the risk of relapse, recurrence, sustained remission or recovery in adults with major depressive disorder who meet criteria for remission or recovery. \ud \ud SEARCH METHODS: We searched the Cochrane Library (current issue); Ovid MEDLINE (1946 onwards); Ovid Embase (1980 onwards); Ovid PsycINFO (1806 onwards); and Web of Science (1900 onwards) up to May 2020. We also searched sources of grey literature, screened the reference lists of included studies and performed a forward citation search. There were no restrictions applied to the searches by date, language or publication status . \ud \ud SELECTION CRITERIA: We included development and external validation (testing model performance in data separate from the development data) studies of any multivariable prognostic models (including two or more predictors) to predict relapse, recurrence, sustained remission, or recovery in adults (aged 18 years and over) with remitted depression, in any clinical setting. We included all study designs and accepted all definitions of relapse, recurrence and other related outcomes. We did not specify a comparator prognostic model. \ud \ud DATA COLLECTION AND ANALYSIS: Two review authors independently screened references; extracted data (using a template based on the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies (CHARMS)); and assessed risks of bias of included studies (using the Prediction model Risk Of Bias ASsessment Tool (PROBAST)). We referred any disagreements to a third independent review author. Where we found sufficient (10 or more) external validation studies of an individual model, we planned to perform a meta-analysis of its predictive performance, specifically with respect to its calibration (how well the predicted probabilities match the observed proportions of individuals that experience the outcome) and discrimination (the ability of the model to differentiate between those with and without the outcome). Recommendations could not be qualified using the GRADE system, as guidance is not yet available for prognostic model reviews. \ud \ud MAIN RESULTS: We identified 11 eligible prognostic model studies (10 unique prognostic models). Seven were model development studies; three were model development and external validation studies; and one was an external validation-only study. Multiple estimates of performance measures were not available for any of the models and, meta-analysis was therefore not possible. Ten out of the 11 included studies were assessed as being at high overall risk of bias. Common weaknesses included insufficient sample size, inappropriate handling of missing data and lack of information about discrimination and calibration. One paper (Klein 2018) was at low overall risk of bias and presented a prognostic model including the following predictors: number of previous depressive episodes, residual depressive symptoms and severity of the last depressive episode. The external predictive performance of this model was poor (C-statistic 0.59; calibration slope 0.56; confidence intervals not reported). None of the identified studies examined the clinical utility (net benefit) of the developed model.\ud \ud AUTHORS' CONCLUSIONS: Of the 10 prognostic models identified (across 11 studies), only four underwent external validation. Most of the studies (n = 10) were assessed as being at high overall risk of bias, and the one study that was at low risk of bias presented a model with poor predictive performance. There is a need for improved prognostic research in this clinical area, with future studies conforming to current best practice recommendations for prognostic model development/validation and reporting findings in line with the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) statement.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 18visibility views 18 download downloads 87 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 CanadaOvid Technologies (Wolters Kluwer Health) Authors: Daniella C. Terenzi; Subodh Verma; David A. Hess;Daniella C. Terenzi; Subodh Verma; David A. Hess;pmid: 33626913
Scholarship@Western arrow_drop_down Arteriosclerosis Thrombosis and Vascular BiologyOther literature type . 2021Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Scholarship@Western arrow_drop_down Arteriosclerosis Thrombosis and Vascular BiologyOther literature type . 2021Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaMDPI AG UKRI | AlwaysCleanUKRI| AlwaysCleanAuthors: Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;Shannon L. Stewart; Ashley Toohey; Angela Celebre; Jeff Poss;pandemic n = 3197) from mental health agencies across Ontario, Canada using the interRAI Child and Youth Mental Health assessment. Our findings revealed no increased incidence of witnessing domestic violence nor experiencing physical, sexual, or emotional abuse. Further, there were no increases in the risk of self-harm and suicide, anxiety, or depression among our sample of clinically referred youth. Finally, results demonstrated no increase in problematic videogaming/internet use, disordered eating, or alcohol intoxication, and a decrease in cannabis use. Our findings add to the growing body of knowledge as to the impact of the COVID-19 pandemic on children and youth. Further, findings underscore the importance of understanding the nuanced impact of the pandemic on various subgroups of children, youth, and families and highlight the need for continued monitoring of outcomes for these children and youth. Throughout the COVID-19 pandemic, population surveys revealed increased levels of anxiety and depression, while findings from large-scale population data analyses have revealed mixed findings with respect to the mental health consequences for children and youth. The purpose of this study was to examine the impact of the COVID-19 pandemic on the well-being and health-compromising behaviors of adolescents (12–18 years) previously referred for mental health services. Data were collected (pre-pandemic n = 3712
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2021License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaBMJ Robert Smith; Sze Chai Hung; Joyce Goh; Hoi Lam Ip; Daniel Y. T. Fong; Shehzad Ali; Claire A Wilson; Kris Yuet Wan Lok;IntroductionPerinatal depression is common and can often lead to adverse health outcomes for mother and child. Multiple pharmacological and non-pharmacological treatments have been evaluated against usual care or placebo controls in meta-analyses for preventing and treating perinatal depression compared. It is not yet established which of these candidate treatments might be the optimal approach for prevention or treatment.Methods and analysisA systematic review and Bayesian network meta-analyses will be conducted. Eight electronic databases shall be searched for randomised controlled trials that have evaluated the effectiveness of treatments for prevention and/or treatment of perinatal depression. Screening of articles shall be conducted by two reviewers independently. One network meta-analysis shall evaluate the effectiveness of interventions in preventing depression during the perinatal period. A second network meta-analysis shall compare the effectiveness of treatments for depression symptoms in women with perinatal depression. Bayesian 95% credible intervals shall be used to estimate the pooled mean effect size of each treatment, and surface under cumulative ranking area will be used to rank the treatments’ effectiveness.Ethics and disseminationWe shall report our findings so that healthcare providers can make informed decisions on what might be the optimal approach for addressing perinatal depression to prevent cases and improve outcomes in those suffering from depression through knowledge exchange workshops, international conference presentations and journal article publications.PROSPERO registration numberCRD42020200081.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2021 Sweden, CanadaOxford University Press (OUP) Lydia Kapiriri; Suzanne N Kiwanuka; Godfrey Biemba; Claudia Velez; S Donya Razavi; Julia Abelson; Beverley M Essue; Marion Danis; Susan Dorr Goold; Mariam Noorulhuda; Elysée Nouvet; Lars Sandman; Iestyn Williams;Priority setting represents an even bigger challenge during public health emergencies than routine times. This is because such emergencies compete with routine programmes for the available health resources, strain health systems and shift health-care attention and resources towards containing the spread of the epidemic and treating those that fall seriously ill. This paper is part of a larger global study, the aim of which is to evaluate the degree to which national COVID-19 preparedness and response plans incorporated priority setting concepts. It provides important insights into what and how priority decisions were made in the context of a pandemic. Specifically, with a focus on a sample of 18 African countries pandemic plans, the paper aims to: (1) explore the degree to which the documented priority setting processes adhere to established quality indicators of effective priority setting and (2) examine if there is a relationship between the number of quality indicators present in the pandemic plans and the countrys economic context, health system and prior experiences with disease outbreaks. All the reviewed plans contained some aspects of expected priority setting processes but none of the national plans addressed all quality parameters. Most of the parameters were mentioned by less than 10 of the 18 country plans reviewed, and several plans identified one or two aspects of fair priority setting processes. Very few plans identified equity as a criterion for priority setting. Since the parameters are relevant to the quality of priority setting that is implemented during public health emergencies and most of the countries have pre-existing pandemic plans; it would be advisable that, for the future (if not already happening), countries consider priority setting as a critical part of their routine health emergency and disease outbreak plans. Such an approach would ensure that priority setting is integral to pandemic planning, response and recovery. Funding Agencies|McMaster University COVID-19 research fund
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Canada, United StatesSpringer Science and Business Media LLC Shawn N. Whitehead; Askiel Bruno; Jeffrey M. Burns; S. Thomas Carmichael; Anna Csiszar; Jodi D. Edwards; Fanny M. Elahi; Giuseppe Faraco; Douglas B. Gould; Deborah Gustafson; Vladimir Hachinski; Gary A. Rosenberg; Farzaneh A. Sorond; Andy Y. Shih; Kai Hei Tse; Zoltan Ungvari; Donna M. Wilcock; Kristen L. Zuloaga; Frank C. Barone;White matter pathologies are critically involved in the etiology of vascular cognitive impairment–dementia (VCID), Alzheimer’s disease (AD), and Alzheimer’s disease and related diseases (ADRD), and therefore need to be considered a treatable target ( Roseborough A, Hachinski V, Whitehead S. White matter degeneration - a treatable target? Roseborough et al. JAMA Neurol [Internet]. 2020 Apr 27;77(7):793–4, [1] . To help address this often-missed area of research, several workshops have been sponsored by the Leo and Anne Albert Charitable Trust since 2015, resulting in the incorporation of “The Albert Research Institute for White Matter and Cognition” in 2020. The first annual “Institute” meeting was held virtually on March 3–4, 2021. The Institute provides a forum and workspace for communication and support of the advancement of white matter science and research to better understand the evolution and prevention of dementia. It serves as a platform for young investigator development, to introduce new data and debate biology mechanisms and new ideas, and to encourage and support new research collaborations and directions to clarify how white matter changes, with other genetic and health risk factors, contribute to cognitive impairment. Similar to previous Albert Trust–sponsored workshops (Barone et al. in J Transl Med 14:1–14, [2]; Sorond et al. in GeroScience 42:81–96, [3]), established expert investigators were identified and invited to present. Opportunities to attend and present were also extended by invitation to talented research fellows and younger scientists. Also, updates on institute-funded research collaborations were provided and discussed. The summary that follows is a synopsis of topics and discussion covered in the workshop.
Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, Netherlands, Italy, Netherlands, Portugal, Canada, Italy, Germany, Italy, Netherlands, Netherlands, United Kingdom, Portugal, BelgiumElsevier BV EC | Solve-RDEC| Solve-RDSergi Borrego-Écija; Roser Sala-Llonch; John C. van Swieten; Barbara Borroni; Fermin Moreno; Mario Masellis; Carmela Tartaglia; Caroline Graff; Daniela Galimberti; Robert Laforce; James B. Rowe; Elizabeth Finger; Rik Vandenberghe; Fabrizio Tagliavini; Alexandre de Mendonça; Isabel Santana; Matthis Synofzik; Simon Ducharme; Johannes Levin; Adrian Danek; Alexander Gerhard; Markus Otto; Christopher C Butler; Giovanni B. Frisoni; Sandro Sorbi; Carolin Heller; Martina Bocchetta; David M. Cash; Rhian S Convery; Katrina M. Moore; Jonathan D. Rohrer; Raquel Sánchez-Valle; Martin N. Rossor; Nick C. Fox; Ione O.C. Woollacott; Rachelle Shafei; Caroline V. Greaves; Mollie Neason; Rita Guerreiro; Jose Bras; David L. Thomas; Jennifer M. Nicholas; Simon Mead; Lieke H.H. Meeter; Jessica L. Panman; Janne M. Papma; Rick van Minkelen; Yolande A.L. Pijnenburg; Begoña Indakoetxea; Alazne Gabilondo; Mikel TaintaMD; Maria de Arriba; Ana Gorostidi; Miren Zulaica; Jorge Villanua; Zigor Diaz; Jaume Olives; Albert Lladó; Mircea Balasa; Anna Antonell; Núria Bargalló; Enrico Premi; Maura Cosseddu; Stefano Gazzina; Alessandro Padovani; Roberto Gasparotti; Silvana Archetti; Sandra E. Black; Sara Mitchell; Ekaterina Rogaeva; Morris Freedman; Ron Keren; David F. Tang-Wai; Linn Öijerstedt; Christin Andersson; Vesna Jelic; Håkan Thonberg; Andrea Arighi; Chiara Fenoglio; Elio Scarpini; Giorgio Fumagalli; Thomas E. Cope; Carolyn Timberlake; Timothy Rittman; Christen Shoesmith; Robart Bartha; Rosa Rademakers; Carlo Wilke; Benjamin Bender; Rose Bruffaerts; Philip Vandamme; Mathieu Vandenbulcke; Carolina Maruta; C. Ferreira; Gabriel Miltenberger; Ana Verdelho; Sónia Afonso; Ricardo Taipa; Paola Caroppo; Giuseppe Di Fede; Giorgio Giaccone; Sara Prioni; Veronica Redaelli; Giacomina Rossi; Pietro Tiraboschi; Diana Duro; Maria Rosário Almeida; Miguel Castelo-Branco; Maria João Leitão; Miguel Tábuas-Pereira; Beatriz Santiago; Serge Gauthier; Pedro Rosa-Neto; Michele Veldsman; Toby Flanagan; Catharina Prix; Tobias Hoegen; Elisabeth Wlasich; Sandra V. Loosli; Sonja Schönecker; Elisa Semler; Sarah Anderl-Straub;handle: 10451/46269 , 2158/1230440 , 11379/576269 , 11572/355946 , 10400.16/2850 , 2434/902153
pmc: PMC7804836
pmid: 33418170
handle: 10451/46269 , 2158/1230440 , 11379/576269 , 11572/355946 , 10400.16/2850 , 2434/902153
pmc: PMC7804836
pmid: 33418170
The authors thank all the volunteers for their participation in this study. SBE is a recipient of the Rio-Hortega post-residency grant from the Instituto de Salud Carlos III, Spain. This study was partially funded by Fundació Marató de TV3, Spain (grant no. 20143810 to RSV). The GENFI study has been supported by the Medical Research Council UK, the Italian Ministry of Health and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, as well as other individual funding to investigators. KM has received funding from an Alzheimer’s Society PhD studentship. JDR acknowledges support from the National Institute for Health Research (NIHR) Queen Square Dementia Biomedical Research Unit and the University College London Hospitals Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre, the UK Dementia Research Institute, Alzheimer’s Research UK, the Brain Research Trust and the Wolfson Foundation. JCvS was supported by the Dioraphte Foundation grant 09-02-03-00, the Association for Frontotemporal Dementias Research Grant 2009, The Netherlands Organization for Scientific Research (NWO) grant HCMI 056-13-018, ZonMw Memorabel (Deltaplan Dementie, project number 733 051 042), Alzheimer Nederland and the Bluefield project. CG have received funding from JPND-Prefrontals VR Dnr 529-2014-7504, VR: 2015-02926, and 2018-02754, the Swedish FTD Initiative-Schörling Foundation, Alzheimer Foundation, Brain Foundation and Stockholm County Council ALF. DG has received support from the EU Joint Programme – Neurodegenerative Disease Research (JPND) and the Italian Ministry of Health (PreFrontALS) grant 733051042. JBR is funded by the Wellcome Trust (103838) and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. MM has received funding from a Canadian Institutes of Health Research operating grant and the Weston Brain Institute and Ontario Brain Institute. RV has received funding from the Mady Browaeys Fund for Research into Frontotemporal Dementia. EF has received funding from a CIHR grant #327387. JDR is an MRC Clinician Scientist (MR/M008525/1) and has received funding from the NIHR Rare Diseases Translational Research Collaboration (BRC149/NS/MH), the Bluefield Project and the Association for Frontotemporal Degeneration. MS was supported by a grant 779257 “Solve-RD” from the Horizon 2020 research and innovation programme. Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 noncarriers from the Genetic Frontotemporal dementia initiative (GENFI), with MRI structural images. We analyzed 3T MRI structural images using the FreeSurfer pipeline to calculate the whole brain cortical thickness (CTh) for each subject. We also perform a vertex-wise general linear model to assess differences between groups in the relationship between CTh and diverse covariables as gender, age, the estimated years to onset and education. We also explored differences according to TMEM106B genotype, a possible disease modifier. Whole brain CTh did not differ between carriers and noncarriers. Both groups showed age-related cortical thinning. The group-by-age interaction analysis showed that this age-related cortical thinning was significantly greater in GRN carriers in the left superior frontal cortex. TMEM106B did not significantly influence the age-related cortical thinning. Our results validate and expand previous findings suggesting an increased CTh loss associated with age and estimated proximity to symptoms onset in GRN carriers, even before the disease onset. © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
Europe PubMed Centra... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2021License: CC BY NC NDRepositório Científico do Centro Hospitalar do PortoArticle . 2021License: CC BYData sources: Repositório Científico do Centro Hospitalar do PortoFlore (Florence Research Repository)Article . 2021Data sources: Flore (Florence Research Repository)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 92visibility views 92 download downloads 135 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2021License: CC BY NC NDRepositório Científico do Centro Hospitalar do PortoArticle . 2021License: CC BYData sources: Repositório Científico do Centro Hospitalar do PortoFlore (Florence Research Repository)Article . 2021Data sources: Flore (Florence Research Repository)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaElsevier BV Shamini Selvarajah; Sophie Plante; Marsha Speevak; Andrea K. Vaags; Darren Hamelinck; Martin Butcher; Elizabeth McCready; Daria Grafodatskaya; Normand Blais; Danh Tran-Thanh; Xiaoduan Weng; Rami Nassabein; Wenda L. Greer; R. Walton; Bryan Lo; Doug Demetrick; Stephanie Santos; Bekim Sadikovic; Xiao Zhang; Tong Zhang; Tara Spence; Tracy Stockley; Harriet Feilotter; Philippe Joubert;Abstract Introduction Genotyping circulating tumor DNA (ctDNA) is a promising noninvasive clinical tool to identify the EGFR T790M resistance mutation in patients with advanced NSCLC with resistance to EGFR inhibitors. To facilitate standardization and clinical adoption of ctDNA testing across Canada, we developed a 2-phase multicenter study to standardize T790M mutation detection using plasma ctDNA testing. Methods In phase 1, commercial reference standards were distributed to participating clinical laboratories, to use their existing platforms for mutation detection. Baseline performance characteristics were established using known and blinded engineered plasma samples spiked with predetermined concentrations of T790M, L858R, and exon 19 deletion variants. In phase II, peripheral blood collected from local patients with known EGFR activating mutations and progressing on treatment were assayed for the presence of EGFR variants and concordance with a clinically validated test at the reference laboratory. Results All laboratories in phase 1 detected the variants at 0.5 % and 5.0 % allele frequencies, with no false positives. In phase 2, the concordance with the reference laboratory for detection of both the primary and resistance mutation was high, with next-generation sequencing and droplet digital polymerase chain reaction exhibiting the best overall concordance. Data also suggested that the ability to detect mutations at clinically relevant limits of detection is generally not platform-specific, but rather impacted by laboratory-specific practices. Conclusions Discrepancies among sending laboratories using the same assay suggest that laboratory-specific practices may impact performance. In addition, a negative or inconclusive ctDNA test should be followed by tumor testing when possible.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 France, Netherlands, Germany, Canada, Netherlands, Netherlands, Spain, France, Netherlands, NetherlandsWiley Jennifer Faber; Tamara Schaprian; Koyak Berkan; Kathrin Reetz; Marcondes C. França; Thiago Junqueira Ribeiro de Rezende; Jiang Hong; Weihua Liao; Bart P.C. van de Warrenburg; Judith van Gaalen; Alexandra Durr; Fanny Mochel; Paola Giunti; Hector Garcia-Moreno; L. Schoels; Holger Hengel; Matthis Synofzik; Benjamin Bender; Gülin Öz; James M. Joers; Jereon J. de Vries; Jun Suk Kang; Dagmar Timmann-Braun; Heike Jacobi; Jon Infante; Richard Joules; Sandro Romanzetti; Jörn Diedrichsen; Matthias Schmid; Robin Wolz; Thomas Klockgether;BACKGROUND: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity. OBJECTIVE: The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease. METHODS: We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers and 63 healthy controls. In addition, cervical cord cross-sectional areas were determined at 2 levels. RESULTS: The metrics of cervical spinal cord segments C3 and C2, medulla oblongata, pons, and pallidum, and the cerebellar anterior lobe were reduced in preataxic mutation carriers compared with controls. Those of cervical spinal cord segments C2 and C3, medulla oblongata, pons, midbrain, cerebellar lobules crus II and X, cerebellar white matter, and pallidum were reduced in ataxic compared with nonataxic carriers. Of all metrics studied, pontine volume showed the steepest decline across the disease course. It covaried with ataxia severity, CAG repeat length, and age. The multivariate model derived from this analysis explained 46.33% of the variance of pontine volume. CONCLUSION: Regional brain and spinal cord tissue loss in spinocerebellar ataxia type 3 starts before ataxia onset. Pontine volume appears to be the most promising imaging biomarker candidate for interventional trials that aim at slowing the progression of spinocerebellar ataxia type 3. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Contains fulltext : 244289.pdf (Publisher’s version ) (Open Access)
NARCIS arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2021Data sources: Universitätsbibliographie, Universität Duisburg-EssenPublikationsserver der RWTH Aachen UniversityArticle . 2021Data sources: Publikationsserver der RWTH Aachen Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu34 citations 34 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 21visibility views 21 download downloads 36 Powered bymore_vert NARCIS arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2021Data sources: Universitätsbibliographie, Universität Duisburg-EssenPublikationsserver der RWTH Aachen UniversityArticle . 2021Data sources: Publikationsserver der RWTH Aachen Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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